Cosmetic product containing adenosine

Abstract

The invention relates to: an aqueous sprayable hair tonic with a pH value of 3.0 to 7.0 at 20°C, containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.%, and a buffering system for stabilising the pH value, wherein the hair tonic comprises less than 18 wt.%, preferably at most 10 wt.%, in particular at most 5 wt.% ethanol; and the use of a sprayable aqueous preparation containing adenosine and urea and / or a urea derivative, with an ethanol content of less than 18 wt.%, for the cosmetic treatment of the skin, in particular the scalp.

Description

[0001] Cosmetic product containing adenosine

[0002] The invention is an invention in the field of hair tonics. It relates to sprayable aqueous compositions with skin and hair care effects containing adenosine.

[0003] The present invention relates to a hair tonic with hair-care effects, such as preventing hair loss and promoting hair growth. Adenosine is an active ingredient used in various cosmetic preparations, such as hair tonics, to prevent hair loss and promote hair growth. Such preparations are preferably sprayed onto the scalp and hair for easy application and should be able to be applied without weighing down the hair.

[0004] It is desirable to be able to use high concentrations of adenosine in these products in order to achieve a satisfactory effect for the user. High concentrations of between 0.1 and 1.5 wt.% adenosine can currently only be delivered in sprayable products with an ethanol content of at least 20 wt.%. Adenosine cannot be incorporated stably into sprayable products with a lower ethanol content. However, products with such a high alcohol content lead to severe drying of the consumer's scalp and to faster fading of colored hair. Therefore, it is desirable to provide a product that overcomes these disadvantages.

[0005] It was therefore the aim of the present invention to provide stable sprayable aqueous compositions in which adenosine is present in a high concentration and which do not dry out the scalp.

[0006] Surprisingly, it was found that this task can be solved with a composition comprising urea or a urea derivative and adenosine and the pH value of the composition is stabilized by a buffer system.

[0007] A first subject matter of the present application is therefore an aqueous sprayable hair tonic having a pH of 3.0 to 7.0 at 20 °C containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.% and a buffer system for stabilizing the pH, characterized in that the hair tonic contains less than 18 wt.%, preferably a maximum of 10 wt.%, in particular a maximum of 5 wt.% ethanol.

[0008] The urea derivative can be used in combination with urea or instead thereof, the total amount being maintained at 1.0 to 20 wt.%. If a urea derivative is used, it is preferably 2-hydroxyethylurea. In these cases, 2-hydroxyethylurea is preferably used in amounts of 1.0 to 15 wt.%, particularly preferably in amounts of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%. 2-hydroxyethylurea is preferably used in combination with urea. In these cases, the preferred amount of urea is 0.05 to 3.0 wt.%, particularly preferably 0.1 to 1.0 wt.%, in particular 0.1 to 0.5 wt.%, and the preferred amount of 2-hydroxyethylurea is 1.0 to 15 wt.%, particularly preferably 1.5 to 7 wt.%, in particular 2.0 to 5.0 wt.%. In such combinations, the ratio of 2-hydroxyethylurea to urea is particularly preferably 20:1 to 10:1.

[0009] A preferred article is therefore an aforementioned hair tonic, wherein the urea derivative is 2-hydroxyethylurea.

[0010] A further preferred article is an aforementioned hair tonic, wherein the total amount of urea and / or a urea derivative is 1.0 to 15 wt.%, preferably 2.0 to 7.0 wt.%, more preferably 2.0 to 5.0 wt.%.

[0011] The claimed hair tonic contains adenosine in an amount of 0.05 to 3 wt.%. Adenosine is a nucleotide and consists of the nucleic base adenine and the sugar ß-D-ribose. Preferred agents contain adenosine in an amount of 0.1 to 2 wt.%, in particular 0.1 to 1 wt.%. Furthermore, agents containing adenosine in amounts of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, may be preferred.

[0012] It is therefore a preferred object if the hair tonic contains adenosine in an amount of 0.1 to 2% by weight, in particular 0.1 to 1% by weight.

[0013] The claimed hair tonic contains adenosine as an active ingredient. The claimed hair tonic contains adenosine as an active ingredient. The hair tonic can also contain adenosine derivatives, such as adenosine 5'-phosphates. It is preferred that the claimed agent contains only a limited amount of adenosine derivatives, such as adenosine 5'-phosphates, e.g. adenosine monophosphate (INCI: Adenosine Phosphate), adenosine diphosphate and / or adenosine triphosphate (INCI: Adenosine Triphosphate). It is preferred that the agent contains less than 0.5% by weight, particularly preferably less than 0.2% by weight, in particular less than 0.1% by weight, of the group of adenosine phosphates. In particular, it can be preferred that the agent is free of adenosine phosphates.Free from adenosine phosphates in this context means that adenosine phosphates are neither added as a separate ingredient nor incorporated into the claimed product via preparations of other ingredients, for example in amounts of up to 0.001% by weight based on the total mass of the product.

[0014] The claimed composition is stabilized by a buffer system. In particular, this enables storage at elevated temperatures, such as 40°C. The buffer substances and their concentrations are preferably selected such that the active ingredients contained are stabilized in the aqueous composition. Stabilization also occurs at elevated temperatures, such as 40°C; all pH values ​​stated in this application apply to measurements at 20°C. Any type of buffer system suitable for cosmetic products can be used that stabilizes the desired pH range and maintains it in the range of 3.0 to 7.0, preferably 4.0 to 6.0, in particular 4.2 to 5.5. This is preferably a lactic acid / lactate buffer, for example containing sodium lactate, or a citric acid / disodium hydrogen phosphate buffer.

[0015] If a lactic acid / sodium lactate buffer is used, different concentrations are possible. It is preferred if the concentration of lactic acid is between 0.5 and 3.5 wt.% and that of sodium lactate between 1.5 and 20 wt.%, based on the total composition. In particular, it is preferred that the ratio of lactic acid to sodium lactate is between 0.02 and 2.3 within this range.

[0016] For some articles, the concentration of lactic acid is preferably 0.5 to 2 wt.% and of sodium lactate 1.5 to 2.5 wt.%, based on the total composition. In particular, it is preferred that in this range the ratio of lactic acid to sodium lactate is 0.3 to 0.8. For other articles, the concentration of lactic acid is preferably 2 to 3 wt.%, particularly preferably 2.2 to 2.6 wt.%, and of sodium lactate 13 to 20 wt.%, particularly preferably 15.5 to 17.0 wt.%, based on the total composition. In particular, it is preferred that in this range the ratio of lactic acid to sodium lactate is 0.1 to 0.2.

[0017] If a citric acid / disodium hydrogen phosphate buffer is used, the concentration of citric acid monohydrate is preferably 0.5 to 1.5 wt.% and of disodium hydrogen phosphate dihydrate is preferably 0.8 to 2.5 wt.%, based on the total composition. If citric acid and / or disodium hydrogen phosphate are used in anhydrous form, the concentrations must be reduced accordingly.

[0018] In particular, it is preferred that in this amount range the ratio of citric acid monohydrate to disodium hydrogen phosphate dihydrate is 0.2 to 2.0.

[0019] It is therefore preferred that the claimed hair tonic comprises a lactic acid / sodium lactate buffer which stabilizes the pH of the agent and maintains it in a range of 3.0 to 7.0, preferably 4.0 to 6.0, in particular 4.2 to 5.5.

[0020] It is also preferred for other claimed agents that the hair tonic contains a citric acid / disodium hydrogen phosphate buffer, which stabilizes the pH of the agent and keeps it in a range of 3.0 to 7.0, preferably 4.0 to 6.0, in particular 4.2 to 5.5.

[0021] Preferably, the previously specified amounts of buffer substances are used for all subsequent compositions so that they can fulfill the stated purpose.

[0022] The claimed hair tonic contains less than 18% by weight, preferably a maximum of 10% by weight, in particular a maximum of 5% by weight, of ethanol. A preferred article is a hair tonic as described above, which contains 5.0 to 10.0% by weight of ethanol. Another preferred article is a hair tonic as described above, which contains a maximum of 5% by weight, particularly preferably less than 1% by weight, especially preferably less than 0.5% by weight, of ethanol, or which is free of ethanol. Free of ethanol in this context means that ethanol is neither added as a separate ingredient nor introduced into the claimed agent via preparations of other ingredients, for example in amounts of up to 2% by weight based on the total mass of the agent.

[0023] A preferred article is therefore an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.%, ethanol in an amount of 5.0 to 10 wt.% and a buffer system for stabilizing the pH.

[0024] A further preferred article is therefore an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and / or 2-hydroxyethylurea in a total amount of 1.0 to 15 or 20 wt.%, preferably 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.05 to 3 wt.%, preferably 0.1 to 2 wt.%, particularly preferably 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of 5.0 to 10 wt.% and a buffer system for stabilizing the pH.

[0025] The claimed aqueous sprayable hair tonic can be easily applied to the relevant areas by the user because it is sprayable and can therefore be distributed finely and evenly. In order to ensure good sprayability, the hair treatment composition according to the invention is preferably free from viscosity-increasing ingredients, such as the polyquaternium polymers known under the INCI names Polyquarternium-10 and Polyquarternium 37, as long as this is compatible with economical operation, i.e. as long as small amounts of corresponding substances are not introduced as minor components or impurities of customary ingredients. Such and comparable viscosity-increasing ingredients are preferably present in the hair treatment composition according to the invention in a concentration of no more than 2% by weight, furthermore preferably no more than 0.5% by weight, and particularly preferably no more than 0.1% by weight.-% based on the total weight of the hair treatment composition.

[0026] It is preferred according to the invention that the claimed hair tonic preferably has a viscosity of at most 150 mPa*s, particularly preferably from 0.8 to 50 mPa*s, in particular 1.0 to 20.0 mPa*s, measured with a Brookfield rotational viscometer (type DV1, spindle 1, 20 RPM) in order to ensure good sprayability.

[0027] A preferred article is thus a claimed hair tonic as described above, which has a viscosity of at most 150 mPa*s, particularly preferably from 0.8 to 50 mPa*s, in particular 1.0 to 20.0 mPa*s, measured with a Brookfield rotational viscometer (type DV1, spindle 1, 20 RPM).

[0028] The aqueous embodiments contain a certain amount of water. Embodiments containing water in an amount of 50 to 99 wt.%, particularly preferably 65 to 95 wt.%, and especially 70 to 90 wt.% are preferred. Water primarily serves to adjust the concentrations of the previously defined ingredients to a range suitable for the aqueous, sprayable hair tonic.

[0029] The claimed hair tonic may contain one or more excipients. These optional excipients can further stabilize hair tonics with a very low ethanol content. A preferred article is therefore a hair tonic containing at least one excipient from the group consisting of diols, polyethylene glycols, glycol ethers, glycerin, polymerized glycerin derivatives, amine oxides, betaines, amino alcohols, and lactate salts, or mixtures thereof. A preferred article is also a hair tonic as described above, which contains a maximum of 5% by weight, particularly preferably less than 1% by weight, especially preferably less than 0.5% by weight, of ethanol and at least one excipient from the group consisting of diols, polyethylene glycols, glycol ethers, glycerin, polymerized glycerin derivatives, amine oxides, betaines, amino alcohols, and lactate salts, or mixtures thereof.

[0030] Hair tonics containing such excipients preferably contain these excipients in a total amount of 0.5 to 35% by weight, preferably up to 25% by weight, in particular up to 15% by weight.

[0031] A preferred article is therefore an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.%, ethanol in an amount of less than 18 wt.% and preferably at most 5 wt.%, particularly preferably less than 1 wt.%, especially preferably less than 0.5 wt.%, and a buffer system for stabilizing the pH, at least one auxiliary substance selected from the group of diols, polyethylene glycols, glycol ethers, glycerol, polymerized glycerol derivatives, amine oxides, betaines, amino alcohols and lactate salts or mixtures of these, preferably in an amount of 0.5 to 25 wt.%, particularly preferably up to 15 wt.%, in particular up to 10 wt.%.

[0032] A preferred article is therefore a claimed hair tonic which additionally contains at least one diol as an optional excipient. The diol can preferably be ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,2-butylene glycol, 1,2-pentylene glycol or dipropylene glycol or mixtures thereof. If at least one diol is used as an excipient, this diol or the mixture of several diols is preferably contained in the claimed agent in a total amount of 0.5 to 20 wt.%. More preferably, the diol is 1,2-propylene glycol and / or 1,2-pentylene glycol. If 1,2-propylene glycol is used as an excipient, it is preferably contained in the claimed agent in an amount of 2 to 20 wt.%, particularly preferably 3 to 15 wt.%. If 1,2-pentylene glycol is used as an excipient, it is preferably contained in the claimed agent in an amount of 0.5 to 5% by weight, particularly preferably 1 to 3.5% by weight.A preferred article is therefore an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, particularly preferably less than 0.5 wt.% and a buffer system for stabilizing the pH, as well as 1,2-propylene glycol preferably in an amount of 2 to 20 wt.%, particularly preferably 3 to 15 wt.%.

[0033] A further preferred article is therefore an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and / or 2-hydroxyethylurea in a total amount of 1.0 to 15 or 20 wt.%, preferably 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.05 to 3 wt.%, preferably 0.1 to 2 wt.%, particularly preferably 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, particularly preferably less than 0.5 wt.% and a buffer system for stabilizing the pH, and 1,2-propylene glycol preferably in an amount of 2 to 20 wt.%, particularly preferably 3 to 15 wt.%.

[0034] A particularly preferred article is an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and optionally 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.% and a buffer system for stabilizing the pH, as well as 1,2-propylene glycol preferably in an amount of 3 to 15 wt.%.

[0035] Another particularly preferred article is an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and optionally 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.%, 1,2-propylene glycol preferably in an amount of 3 to 15 wt.% and a buffer system for stabilizing the pH, which is a lactic acid / sodium lactate buffer or a citric acid / disodium hydrogen phosphate buffer, which stabilizes the pH of the agent and preferably keeps it in a range of 4.0 to 6.0.

[0036] A preferred article is therefore also an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, particularly preferably less than 0.5 wt.% and a buffer system for stabilizing the pH, as well as 1,2-pentylene glycol preferably in an amount of 0.5 to 5 wt.%, particularly preferably 1 to 3.5 wt.%.

[0037] A further preferred article is therefore an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and / or 2-hydroxyethylurea in a total amount of 1.0 to 15% by weight, preferably 2.0 to 7.0% by weight, in particular 2.0 to 5.0% by weight, adenosine in an amount of 0.05 to 3% by weight, preferably 0.1 to 2% by weight, particularly preferably 0.2 to 1.5% by weight, in particular 0.5 to 1.0% by weight, ethanol in an amount of at most 5% by weight, preferably less than 1% by weight, particularly preferably less than 0.5% by weight and a buffer system for stabilizing the pH, and 1,2-pentylene glycol preferably in an amount of 0.5 to 5% by weight, particularly preferably 1 to 3.5% by weight.

[0038] A particularly preferred article is an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and optionally 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.% and a buffer system for stabilizing the pH, as well as 1,2-pentylene glycol preferably in an amount of 1 to 3.5 wt.%.

[0039] Another particularly preferred article is an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and optionally 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.%, 1,2-pentylene glycol preferably in an amount of 1 to 3.5 wt.% and a buffer system for stabilizing the pH, which is a lactic acid / sodium lactate buffer or a citric acid / disodium hydrogen phosphate buffer, which stabilizes the pH of the agent and preferably keeps it in a range of 4.0 to 6.0.

[0040] A further preferred article is therefore a claimed hair tonic which additionally contains at least one polyethylene glycol as an optional excipient. The polyethylene glycol can preferably be one or more compounds from the group according to the formula HO-[CH2CH2O]XH, where x is an integer from 2 to 100, preferably 2 to 80, more preferably 2 to 60, even more preferably from 3 to 40 or from 4 to 20. If a polyethylene glycol is used as an optional excipient, this polyethylene glycol or the mixture of several polyethylene glycols is preferably contained in the claimed agent in a total amount of 0.5 to 15 wt.%. The optionally used polyethylene glycol is particularly preferably one in which x is an integer from 3 to 40. If used, it is preferably present in an amount of 0.5 to 15 wt.%, particularly preferably in an amount of 5.0 to 10 wt.-%, contained in the claimed agent.

[0041] It is also possible to use mixtures of the above-mentioned optional excipients as optional excipients. If an optional excipient is used, it is further preferred if a combination of 1,2-propylene glycol and PEG-40, i.e., a polyethylene glycol according to the formula given above, where x = 40 (INCI: PEG-40 Hydrogenated Castor Oil), is used. It is particularly preferred if 1,2-propylene glycol is used in an amount of 1.0 to 15 wt.% and PEG-40 is used in an amount of 0.3 to 5.0 wt.%.

[0042] A further preferred subject matter is therefore a claimed hair tonic which additionally contains at least one glycol ether as an optional excipient. The glycol ether can preferably be one or more compounds from the group of monomethyl ethers, monoethyl ethers, and monopropyl ethers, as well as mixtures thereof. If a glycol ether is used as an optional excipient, this glycol ether is preferably present in the claimed agent in a total amount of 0.5 to 15 wt.%. The optionally used glycol ether is particularly preferably diethylene glycol monoethyl ether. If used, it is preferably present in the claimed agent in an amount of 0.5 to 15 wt.%, particularly preferably in an amount of 5.0 to 10 wt.%.

[0043] A further preferred subject matter is therefore a claimed hair tonic which additionally contains glycerin as an optional excipient. If glycerin is used as an optional excipient, it is preferably present in the claimed agent in an amount of 0.5 to 15 wt.%, particularly preferably in an amount of 3.0 to 10 wt.%.

[0044] A further preferred subject matter is therefore a claimed hair tonic which additionally contains at least one polymerized glycerin derivative as an optional excipient. The polymerized glycerin derivative can be at least one of the polymerized glycerin derivatives known under the INCI names Polyglyceryl-6 Caprylate, Polyglyceryl-4 Caprate, Polyglyceryl-3 Cocoate, Polyglyceryl-6 Ricinoleate, or Polyglyceryl-3 Caprate / Caprylate / Succinate, or mixtures thereof. If at least one polymerized glycerin derivative is used as an optional excipient, this polymerized glycerin derivative is preferably present in the claimed agent in a total amount of 0.3 to 15 wt.%, particularly preferably 2 to 10 wt.%, in particular 5 to 9 wt.%. The polymerized glycerin derivative to be used optionally is particularly preferably a mixture of polyglyceryl-6 caprylate and polyglyceryl-4 caprate.If this mixture is used, it is preferably contained in the claimed agent in a total amount of 0.1 to 15 wt.%, particularly preferably 0.3 to 10 wt.%, in particular 0.5 to 9 wt.%.

[0045] A preferred article is therefore also an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, particularly preferably less than 0.5 wt.% and a buffer system for stabilizing the pH, as well as a mixture of polyglyceryl-6 caprylate and polyglyceryl-4 caprate, preferably in a total amount of 1 to 15 wt.%, particularly preferably 2 to 10 wt.%, in particular 5 to 9 wt.%.

[0046] A further preferred article is therefore an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and / or 2-hydroxyethylurea in a total amount of 1.0 to 15 or 20 wt.%, preferably 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.05 to 3 wt.%, preferably 0.1 to 2 wt.%, particularly preferably 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, particularly preferably less than 0.5 wt.% and a buffer system for stabilizing the pH, as well as a mixture of polyglyceryl-6 caprylate and polyglyceryl-4 caprate, preferably in a total amount of 1 to 15 wt.%, particularly preferably from 2 to 10 wt.%, in particular from 5 to 9 wt.%.

[0047] A particularly preferred article is an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and optionally 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.% and a buffer system for stabilizing the pH, as well as a mixture of polyglyceryl-6 caprylate and polyglyceryl-4 caprate, preferably in a total amount of 5 to 9 wt.%.

[0048] Another particularly preferred article is an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and optionally 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.%, a mixture of polyglyceryl-6 caprylate and polyglyceryl-4 caprate, preferably in a total amount of 5 to 9 wt.% and a buffer system for stabilizing the pH, which is a lactic acid / sodium lactate buffer or a citric acid / disodium hydrogen phosphate buffer, which stabilizes the pH of the agent and preferably keeps it in a range of 4.0 to 6.0. It is also possible to use mixtures of the above-mentioned optional excipients as optional excipients.If an optional excipient is used, it is further preferred if a combination of 1,2-propylene glycol and polyglyceryl-6 caprylate is used. It is particularly preferred if 1,2-propylene glycol is used in an amount of 2.0 to 20 wt.% and polyglyceryl-6 caprylate is used in an amount of 0.3 to 9 wt.%.

[0049] A further preferred subject matter is therefore a claimed hair tonic which additionally contains at least one amine oxide as an optional excipient. The amine oxide can be at least one from the group of (C5- to C18-alkyl)-dimethylamine oxide or mixtures thereof. The C5- to C18-alkyl chain can be, for example, alkyl chains based on different fatty acids or fatty alcohols such as myristyl alcohol, cetyl alcohol, caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, margaric acid, stearic acid, linoleic acid, oleic acid or mixtures thereof. If an amine oxide is used as an optional excipient, this amine oxide is preferably present in the claimed agent in a total amount of 0.2 to 5 wt.%. The optional amine oxide is particularly preferably dodecyldimethylamine oxide (INCI: Lauramine Oxide), cocamine oxide or mixtures thereof.If dodecyldimethylamine oxide is used, it is preferably contained in the claimed agent in a total amount of 0.2 to 10 wt.%, particularly preferably 0.5 to 5 wt.%, in particular 0.5 to 2 wt.%.

[0050] A preferred article is therefore also an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, particularly preferably less than 0.5 wt.% and a buffer system for stabilizing the pH, and dodecyldimethylamine oxide preferably in a total amount of 0.2 to 10 wt.%, particularly preferably 0.5 to 5 wt.%, in particular 0.5 to 2 wt.%.

[0051] A further preferred subject matter is therefore an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20°C containing urea and / or 2-hydroxyethylurea in a total amount of 1.0 to 15 or 20 wt.%, preferably 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.05 to 3 wt.%, preferably 0.1 to 2 wt.%, particularly preferably 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, particularly preferably less than 0.5 wt.% and a buffer system for stabilizing the pH, and dodecyldimethylamine oxide preferably in a total amount of 0.2 to 10 wt.%, particularly preferably 0.5 to 5 wt.%, in particular from 0.5 to 2 wt.%.

[0052] A particularly preferred article is an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and optionally 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.% and a buffer system for stabilizing the pH, and dodecyldimethylamine oxide preferably in a total amount of 0.5 to 2 wt.%.

[0053] Another particularly preferred article is an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and optionally 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.%, dodecyldimethylamine oxide preferably in a total amount of 0.5 to 2 wt.% and a buffer system for stabilizing the pH, which is a lactic acid / sodium lactate buffer or a citric acid / disodium hydrogen phosphate buffer, which stabilizes the pH of the agent and preferably keeps it in a range of 4.0 to 6.0.

[0054] A further preferred subject matter is therefore a claimed hair tonic which additionally contains at least one betaine as an optional excipient. The betaine can preferably be one or more compounds from the group according to formula R-CO-NH-(CH2)3-N + (CH3)2-CH2COO _where R is an alkyl chain with C5 to C21. If a betaine is used as an optional excipient, this betaine or the mixture of several betaines is preferably contained in the claimed agent in a total amount of 0.1 to 5 wt.%. The optionally used betaine is particularly preferably cocamidopropyl betaine (INCI: Cocamidopropyl Betaine), which is a mixture of lauramidopropyl betaine (INCI: Lauramidopropyl Betaine) in which R is a saturated and unbranched C11 alkyl chain and other betaines derived from coconut fatty acids with C8 to C18 alkyl chains. If cocamidopropyl betaine is used, it is preferably contained in the claimed agent in a total amount of 0.1 to 5 wt.%, particularly preferably 0.3 to 3 wt.%, in particular 0.5 to 2 wt.%.

[0055] A preferred article is therefore also an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, particularly preferably less than 0.5 wt.% and a buffer system for stabilizing the pH, and cocamidopropyl betaine preferably in a total amount of 0.1 to 5 wt.%, particularly preferably 0.3 to 3 wt.%, in particular 0.5 to 2 wt.%.

[0056] A further preferred subject matter is therefore an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20°C containing urea and / or 2-hydroxyethylurea in a total amount of 1.0 to 15 or 20 wt.%, preferably 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.05 to 3 wt.%, preferably 0.1 to 2 wt.%, particularly preferably 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, particularly preferably less than 0.5 wt.% and a buffer system for stabilizing the pH, and cocamidopropyl betaine preferably in a total amount of 0.1 to 5 wt.%, particularly preferably 0.3 to 3 wt.%, in particular 0.5 to 2 wt%.

[0057] A particularly preferred article is an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and optionally 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.% and a buffer system for stabilizing the pH, and cocamidopropyl betaine preferably in a total amount of 0.5 to 2 wt.%.

[0058] Another particularly preferred article is an aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and optionally 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.%, cocamidopropyl betaine preferably in a total amount of 0.5 to 2 wt.% and a buffer system for stabilizing the pH, which is a lactic acid / sodium lactate buffer or a citric acid / disodium hydrogen phosphate buffer, which stabilizes the pH of the agent and preferably keeps it in a range of 4.0 to 6.0.

[0059] For all the embodiments encompassed, in which 2-hydroxyethylurea is used alone or in combination with urea, it is preferred that further excipients are included in the composition. It is particularly preferred that an amino alcohol, preferably 2-aminoethanol, and / or a lactate salt, preferably ammonium lactate, are included in an embodiment containing 2-hydroxyethylurea or in an embodiment containing 2-hydroxyethylurea and urea. In this case, it is particularly preferred if the ratio of 2-hydroxyethylurea to 2-aminoethanol is between 100:1 and 50:1. In this case, it is particularly preferred if the ratio of 2-hydroxyethylurea to ammonium lactate is between 15:1 and 25:1.

[0060] In addition to the excipients mentioned above, the claimed hair tonic may contain other ingredients such as fragrances or perfumes, extracts, in particular plant extracts, preservatives, pH adjusters, dyes, other detergent substances and mixtures of these.

[0061] A further subject matter of the present application is also the use of the claimed agent as a hair tonic.

[0062] Stable aqueous compositions containing adenosine in high concentrations have been shown above. A further subject of the present application is therefore the use of urea and / or urea derivatives for stabilizing adenosine in aqueous compositions with an ethanol content of less than 18 wt.%. A further subject of the present application is therefore the use of urea and / or urea derivatives and an excipient selected from the group consisting of diols, polyethylene glycols, glycol ethers, glycerol, polymerized glycerol derivatives, amine oxides, betaines, amino alcohols, and lactate salts, or mixtures thereof, for stabilizing adenosine in aqueous compositions with an ethanol content of up to 5 wt.%.

[0063] The present application accordingly further relates to the use of a sprayable aqueous preparation containing adenosine and urea and / or a urea derivative with an ethanol content of less than 18% by weight for the cosmetic treatment of the skin, in particular the scalp. The present application accordingly further relates to the use of a sprayable aqueous preparation containing adenosine, urea and / or a urea derivative and an excipient selected from the group consisting of diols, polyethylene glycols, glycol ethers, glycerol, polymerized glycerol derivatives, amine oxides, betaines, amino alcohols, and lactate salts, or mixtures thereof, with an ethanol content of less than 18% by weight for the cosmetic treatment of the skin, in particular the scalp.

[0064] All information provided for the described product is also directly applicable to the described uses. This applies in particular, but not exclusively, to the data and characteristics regarding urea (derivative), adenosine, buffer substances and systems, excipients, ethanol content, viscosity, pH value, measurement methods, and other specified ingredients.

[0065] The invention is further described, but not exhaustively, by the following points:

[0066] Item 1: Aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.% and a buffer system for stabilizing the pH, wherein the hair tonic contains less than 18 wt.%, preferably a maximum of 10 wt.%, in particular a maximum of 5 wt.% ethanol.

[0067] Item 2: Agent according to item 1, where the buffer system is a lactic acid / sodium lactate buffer or a citric acid / disodium hydrogen phosphate buffer.

[0068] Item 3: Agent according to one of the above items, wherein the urea derivative is 2-hydroxyethylurea.

[0069] Item 4: Agent according to one of the preceding items, wherein the agent contains at least one excipient from the group of diols, polyethylene glycols, glycol ethers, glycerin, polymerized glycerin derivatives, amine oxides, betaines, amino alcohols and lactate salts or mixtures thereof.

[0070] Item 5: Agents according to item 4, wherein the diol is ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,2-butylene glycol, 1,2-pentylene glycol or dipropylene glycol or mixtures thereof.

[0071] Item 6: Agent according to item 4, wherein the polyethylene glycol is one or more compounds from the group according to formula HO-[CH2CH2O]xH, where x is an integer from 2 to 100, preferably 2 to 80, more preferably 2 to 60, even more preferably from 3 to 40 or from 4 to 20.

[0072] Item 7: Agent according to item 4, wherein the polymerised glycerin derivative is at least one of the polymerised glycerin derivatives known under the INCI names Polyglyceryl-6 Caprylate, Polyglyceryl-4 Caprate, Polyglyceryl-3 Cocoate, Polyglyceryl-6 Ricinoleate or Polyglyceryl-3 Caprate / Caprylate / Succinate or mixtures thereof.

[0073] Item 8: Agent according to item 4, wherein the amine oxide is at least one selected from the group consisting of (C5- to C18-alkyl)-dimethylamine oxide or mixtures thereof.

[0074] Item 9: Agent according to item 9, wherein the betaine is one or more compounds from the group according to formula R-CO-NH-(CH2)3-N + (CH3)2-CH2COO _ where R is an alkyl chain with C5 to C21.

[0075] Item 10: Agent according to item 4, wherein the amino alcohol is 2-aminoethanol and / or the lactate salt is ammonium lactate. Item 11: Agent according to any one of items 4 to 10, wherein the agent contains a maximum of 5% by weight, preferably less than 1% by weight, of ethanol, and is in particular free of ethanol.

[0076] Item 12: Agent according to one of the preceding items, wherein the agent contains less than 0.5% by weight of one or more ingredients from the group of adenosine 5'-phosphates.

[0077] Item 13: Agent according to one of the preceding items, wherein the agent contains 0.1 to 2.0% by weight, preferably 0.1 to 1.0% by weight of adenosine.

[0078] Item 14: Agent according to one of the preceding items, wherein the total amount of urea and / or a urea derivative is 1.0 to 15 wt.%, preferably 2.0 to 7.0 wt.%, more preferably 2.0 to 5.0 wt.%.

[0079] Item 15: Agent according to one of items 4 to 14, wherein the excipient(s) is / are present in a total amount of 0.5 to 35% by weight, preferably in an amount of up to 25% by weight.

[0080] Item 16: Agent according to one of the preceding items, wherein the agent has a viscosity of at most 150 mPa*s, particularly preferably from 0.8 to 50 mPa*s, in particular 1.0 to 20.0 mPa*s measured with a Brookfield rotational viscometer (type DV1, spindle 1, 20 RPM).

[0081] Item 17: Agent according to one of the preceding items, wherein the agent has a pH of 3.0 to 7.0 at 20°C, preferably of 4.0 to 6.0, in particular of 4.2 to 5.5.

[0082] Item 18: Use of urea and / or urea derivative to stabilize adenosine in aqueous compositions with an ethanol content of less than 18% by weight.

[0083] Item 19: Use of a sprayable aqueous preparation containing adenosine and urea and / or a urea derivative with an ethanol content of less than 18% by weight for the cosmetic treatment of the skin, in particular the scalp. Examples of use:

[0084] The following compositions were prepared as follows:

[0085] Adenosine was dissolved in water at 50 °C. Sodium benzoate was added to the 50 °C solution and dissolved. All other ingredients except urea and / or urea derivative and buffer substances were added and dissolved. The buffer substances were then added as aqueous solutions. The solution was then cooled to below 25 °C. Urea and / or urea derivative were added to the solution at a temperature between 20 and 25 °C and dissolved.

[0086] 1 : INCI: Polyglyceryl-6 Caprylate (and) Polyglyceryl-4 Caprate

[0087] The resulting compositions were stored at room temperature (20 °C) and at 40 °C. The pH values ​​of the compositions were determined immediately after preparation and after storage. All compositions were found to be stable at room temperature for at least 3 weeks. When stored at 40 °C for 3 weeks, a strong increase in pH was observed for compositions V1 and V2, indicating decomposition. Compositions E1a-c and E2a-c were also stable at 40 °C for at least this period, with the pH values ​​increasing only slightly.

Claims

Patent claims:

1. Aqueous sprayable hair tonic with a pH of 3.0 to 7.0 at 20 °C containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.% and a buffer system for stabilizing the pH, characterized in that the hair tonic contains less than 18 wt.%, preferably a maximum of 10 wt.%, in particular a maximum of 5 wt.% ethanol.

2. Agent according to claim 1, wherein the buffer system is a lactic acid / sodium lactate buffer or a citric acid / disodium hydrogen phosphate buffer.

3. Agent according to one of the preceding claims, wherein the urea derivative is 2-hydroxyethylurea and / or the total amount of urea and / or a urea derivative 1.0 to 15 wt.%, preferably 2.0 to 7.0 wt.%, more preferably 2.0 to 5.0 wt.%.

4. A composition according to any one of the preceding claims, wherein the composition contains at least one excipient selected from the group consisting of diols, polyethylene glycols, glycol ethers, glycerol, polymerized glycerol derivatives, amine oxides, betaines, amino alcohols and lactate salts or mixtures thereof.

5. The agent according to claim 4, wherein the diol is ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,2-butylene glycol, 1,2-pentylene glycol or dipropylene glycol or mixtures thereof.

6. Agent according to claim 4, wherein the polymerized glycerin derivative is at least one of the polymerized glycerin derivatives known under the INCI names Polyglyceryl-6 Caprylate, Polyglyceryl-4 Caprate, Polyglyceryl-3 Cocoate, Polyglyceryl-6 Ricinoleate or Polyglyceryl-3 Caprate / Caprylate / Succinate or mixtures thereof.

7. Agent according to one of claims 4 to 6, wherein the agent contains a maximum of 5% by weight, preferably less than 1% by weight, of ethanol, in particular is free of ethanol.

8. Agent according to one of the preceding claims, wherein the agent comprises 0.1 to 2.0 wt.%, preferably 0.1 to 1.0 wt.% adenosine.

9. Agent according to one of the preceding claims, wherein the agent has a viscosity of at most 150 mPa*s, particularly preferably from 0.8 to 50 mPa*s, in particular 1.0 to 20.0 mPa*s measured with Brookfield rotational viscometer (type DV1, spindle 1, 20 RPM).

10. Use of a sprayable aqueous preparation containing adenosine and urea and / or a urea derivative with an ethanol content of less than 18% by weight for the cosmetic treatment of the skin, in particular the scalp.

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