Enhancing cytotoxicity of engineered immune effectors through an additional synapse-stabilizing receptor

EP4801556A1Pending Publication Date: 2026-09-09BAYLOR COLLEGE OF MEDICINE
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Patent Information

Application Number
EP2024886806
Authority / Receiving Office
EP · EP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-10-30
Filing Date
2024-10-30
Publication Date
2026-09-09

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Abstract

Aspects of the present disclosure include a synapse stabilizing receptor comprising a LAT domain which can be used in combination with a CAR, a TCR, or a BiTE. Another aspect of the present disclosure are immune cells comprising a synapse stabilizing receptor comprising a LAT domain which can be used in combination with a CAR, a TCR, or a BiTE s and methods for their use in treatment of disease (e.g., cancer).
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