Liquid aliquoting device

Abstract

A liquid dispensing device, including a housing (100) internally partitioned to form a thermal insulation chamber (110) for accommodating a to-be-dispensed container (111) and maintaining a temperature of the to-be-dispensed container (111), as well as a dispensing chamber (120) configured to accommodate multiple dispensing bags (310) and maintain temperatures of the multiple dispensing bags (310); a temperature control mechanism (200) including a first temperature control assembly (210) mounted in the thermal insulation chamber (110) and configured to regulate a temperature in the thermal insulation chamber (110); a dispensing mechanism (300) mounted in the dispensing chamber (120) and configured to dispense liquid in the to-be-dispensed container (111) into the dispensing bags (310); and a liquid path mechanism (400) mounted on the housing (100) and configured to dispense liquid in the to-be-dispensed container (111) into the dispensing bags (310) through the dispensing mechanism (300).

Description

[0001] This application claims priority to the Chinese patent application with application number 202311439941.0, filed with the China National Intellectual Property Administration on October 31, 2023, titled "Liquid Dispensing Device", the entire contents of which are incorporated herein by reference into the present disclosure.TECHNICAL FIELD

[0002] The present disclosure relates to the field of biomedical technology, and more particularly, to a liquid dispensing device.BACKGROUND

[0003] Cell preparation dispensing technology is an important component of the biomedical technology field and is crucial for cell therapy and pharmaceutical preparation. If stable and high-precision dispensing requirements cannot be satisfied, the therapeutic effect of cell preparations may be affected and the treatment opportunity for patients may be delayed. In existing technologies, the liquid volume measurement during dispensing is typically implemented using devices and methods such as manually starting and stopping peristaltic pumps, weighing, and manual recording. The inventor has realized that the above methods are slow in dispensing speed and cannot quickly dispense large doses of cell preparation products into dispensing bags in a short time. In addition, due to the slow dispensing speed during the dispensing process, the integrity and viability of the cell preparations may be damaged by temperature changes, thereby reducing the dispensing quality.SUMMARY OF THE DISCLOSURE

[0004] The present disclosure provides a liquid dispensing device to address the issues of slow dispensing speed and low dispensing quality in existing liquid dispensing devices.

[0005] The dispensing device provided in an embodiment of the present disclosure includes: a housing internally partitioned to form a thermal insulation chamber for accommodating a to-be-dispensed container and maintaining a temperature of the to-be-dispensed container, as well as a dispensing chamber configured to accommodate multiple dispensing bags; a temperature control mechanism including a first temperature control assembly mounted in the thermal insulation chamber and configured to regulate a temperature in the thermal insulation chamber; a dispensing mechanism mounted in the dispensing chamber and configured to dispense liquid in the to-be-dispensed container into the dispensing bags; and a liquid path mechanism mounted on the housing and configured to dispense liquid in the to-be-dispensed container into the dispensing bags through the dispensing mechanism.

[0006] The present disclosure utilizes the liquid path mechanism to dispense the liquid from the to-be-dispensed container into the multiple dispensing bags through the dispensing mechanism, thereby achieving rapid liquid dispensing and improving the liquid dispensing speed. The present disclosure further provides the thermal insulation chamber and the dispensing chamber in a partitioned manner in the housing. The temperature in the thermal insulation chamber is controlled by the temperature control mechanism, while the dispensing chamber can protect the dispensing bags and also provide a thermal insulation effect, thus maintaining the temperature of the cell preparations within the preset temperature range. This avoids damage to the integrity and viability of the cell preparations due to improper temperature, and improves the liquid dispensing quality. The present disclosure improves both the liquid dispensing speed and the liquid dispensing quality, thereby improving the liquid dispensing efficiency.

[0007] The details of one or more embodiments of the present disclosure are presented in the accompanying drawings and descriptions below, and other features and advantages of the present disclosure will become apparent from the specification, drawings, and claims.BRIEF DESCRIPTION OF THE DRAWINGS

[0008] The present disclosure will be further described below in conjunction with the accompanying drawings and embodiments. FIG. 1 is a schematic view of a liquid dispensing device in accordance with an embodiment of the present disclosure. FIG. 2 is a schematic view of a temperature control mechanism in accordance with an embodiment of the present disclosure. FIG. 3 is a schematic view of a liquid path mechanism in accordance with an embodiment of the present disclosure. FIG. 4 is a schematic view of a mixing mechanism in accordance with an embodiment of the present disclosure. FIG. 5 is a schematic view of a mixing mechanism in accordance with another embodiment of the present disclosure.

[0009] Reference signs in the accompanying drawings are as follows: 110, thermal insulation chamber; 111, to-be-dispensed container; 120, dispensing chamber; 121, dispensing bag; 200, temperature control mechanism; 210, first temperature control assembly; 211, first temperature regulator; 2111, compressor; 2112, evaporator; 212, first heat exchanger; 2121, metal tube; 2122, metal sheet; 220, thermal insulation cotton; 230, thermal insulation board; 240, temperature sensor; 300, dispensing mechanism; 310, dispensing bag; 320, dispensing switch valve; 400, liquid path mechanism; 410, quantifying assembly; 411, quantifying tube; 412, first bubble sensor; 413, second bubble sensor; 420, driving assembly; 421, first driving pump; 422, first switch valve; 423, third bubble sensor; 424, second driving pump; 425, second switch valve; 500, mixing mechanism; 510, mounting plate; 520, mixing assembly; 521, linear motion assembly; 5211, driving wheel; 5212, driven wheel; 5213, motor; 5214, timing belt; 5215, connecting block; 5216, guiding shaft; 5217, linear bearing; 5218, first guiding shaft; 5219, second guiding shaft; 522, mixing plate; 600, sample container.PREFERRED EMBODIMENTS

[0010] To make the objectives, technical solutions, and advantages of the present disclosure clearer, the technical solutions of the present disclosure will be clearly and comprehensively described below in conjunction with the accompanying drawings. It is apparent that the described embodiments are a part of the embodiments of the present disclosure, not all embodiments. Based on the embodiments of the present disclosure, all other embodiments obtained by those of ordinary skill in the art without creative effort fall in the scope of protection of the present disclosure.

[0011] It should be understood that orientation or position relationships indicated by the terms such as "up", "down", "left", "right", "front", "back", and "middle" are based on orientation or position relationships shown in the accompanying drawings, and are used only for ease of description of the present disclosure and brevity of the description, rather than indicating or implying that the mentioned apparatus or element needs to have a particular orientation or be constructed and operated in a particular orientation. Therefore, such terms should not be construed as a limitation on the present disclosure.

[0012] As shown in FIG. 1 and FIG. 2, an embodiment of the present disclosure provides a liquid dispensing device, including a housing 100, a temperature control mechanism 200, a dispensing mechanism 300, and a liquid path mechanism 400.

[0013] The housing 100 is internally partitioned to form a thermal insulation chamber 110 for accommodating a to-be-dispensed container 111 and thermally insulating the to-be-dispensed container 111, and a dispensing chamber 120 for accommodating a plurality of dispensing bags 310. In this embodiment, as shown in FIG. 1, the to-be-dispensed container 111 for accommodating liquid is mounted in the thermal insulation chamber 110, and a plurality of dispensing bags 310 are mounted in the dispensing chamber 120. Meanwhile, after a consumable tube set for transmitting fluids (including gases and liquids) is mounted on the liquid dispensing device, the liquid in the to-be-dispensed container 111 can be dispensed. In this embodiment, after the dispensing operation is completed, the next round of dispensing operation can be performed by replacing the consumable tube set, the to-be-dispensed container 111, and the dispensing bags 310, or by directly replacing the dispensing bags 310 (for example, by cutting off an inlet of the dispensing bag 310 through heat sealing, and then heat sealing the replaced dispensing bag 310 to the inlet through a sterile tube welder), thereby improving the dispensing efficiency. In an embodiment, the to-be-dispensed container 111 can communicate with a plurality of the dispensing bags 310 in the dispensing mechanism 300 through a first transfer pipeline in the consumable tube set. After the to-be-dispensed container 111 is placed in the thermal insulation chamber 110, the dispensing bags 310 are mounted in the dispensing chamber 120, and the first transfer pipeline is mounted in the liquid path mechanism 400, the liquid in the to-be-dispensed container 111 can be driven by the liquid path mechanism 400 to be dispensed into the dispensing bags 310 in the dispensing mechanism 300 through the dispensing mechanism 300.

[0014] The temperature control mechanism 200 includes a first temperature control assembly 210 arranged in the thermal insulation chamber 110 and configured to regulate a temperature in the thermal insulation chamber 110. It can be understood that the liquid dispensing device is generally configured to dispense cell preparations, such that the liquid in the to-be-dispensed container 111 is generally a cell preparation. To avoid damaging the integrity and viability of the cell preparation, the cell preparation needs to be stored in a first preset temperature requirement range. The first temperature control assembly 210 may include a first temperature regulator 211 and a first heat exchanger 212 connected to the first temperature regulator 211. The first temperature regulator 211 is configured to regulate its own temperature, and the first heat exchanger 212 is configured to exchange heat in the thermal insulation chamber 110, thereby regulating the temperature in the thermal insulation chamber 110 and controlling a temperature of the liquid in the to-be-dispensed container 111 to meet the first preset temperature requirement range. The first temperature control assembly 210 may only include the first temperature regulator 211, which directly exchanges heat in the thermal insulation chamber 110, thereby regulating the temperature in the thermal insulation chamber 110 and controlling the temperature of the liquid in the to-be-dispensed container 111 to meet the first preset temperature requirement range. The first temperature regulator 211 can perform temperature regulation through means such as compressor cooling and semiconductor cooling. In one embodiment, the first temperature regulator 211 performs temperature regulation through compressor cooling, allowing for faster temperature adjustment. As shown in FIG. 2, the first temperature regulator 211 may include components such as a compressor 2111 and an evaporator 2112. For a specific cooling method, reference may be made to cooling methods of air conditioners and the like, and details are not repeated herein. The first heat exchanger 212 may include heat-conductive components such as a metal tube 2121 and / or a metal sheet 2122. The first heat exchanger 212 can exchange heat in a contact or non-contact manner. In one embodiment, the first heat exchanger 212 exchanges heat with the liquid in the to-be-dispensed container 111 by directly contacting the container 111, allowing for more efficient temperature adjustment of the liquid in the to-be-dispensed container 111.

[0015] The dispensing mechanism 300 is arranged in the dispensing chamber 120 and configured to dispense the liquid contained in the to-be-dispensed container 111 into the dispensing bags 310. The dispensing chamber 120 protects the dispensing bags 310 and also provides a certain level of thermal insulation for the cell preparations contained in the dispensing bags 310.

[0016] The liquid path mechanism 400 is arranged on the housing 100 and configured to dispense the liquid in the to-be-dispensed container 111 into the dispensing bag 310 through the dispensing mechanism 300.

[0017] The present disclosure utilizes the liquid path mechanism 400 to dispense the liquid in the to-be-dispensed container 111 into multiple dispensing bags 310 through the dispensing mechanism 300, thereby achieving rapid liquid dispensing and improving liquid dispensing speed. The present disclosure further provides the thermal insulation chamber 110 and the dispensing chamber 120 in a partitioned manner in the housing 100. The temperature control mechanism 200 controls the temperature in the thermal insulation chamber 110, while the dispensing chamber 120 can protect the dispensing bags 310 and also provide a certain thermal insulation function, thereby maintaining the temperature of the cell preparations within a preset temperature range (including the first preset temperature range mentioned above and the second preset temperature range mentioned later), avoiding damage to the integrity and viability of the cell preparations due to improper temperature, and improving the liquid dispensing quality. The present disclosure improves both the liquid dispensing speed and the liquid dispensing quality, thereby improving the liquid dispensing efficiency.

[0018] In an embodiment, the temperature control mechanism 200 further includes a second temperature control assembly (not shown) arranged in the dispensing chamber 120 and configured to regulate a temperature in the dispensing chamber 120. In this embodiment, the temperature of the dispensing bags 310 in the dispensing chamber 120 can be adjusted by arranging the second temperature control assembly in the dispensing chamber 120, thereby controlling the temperature of the liquid in the dispensing bags 310 to meet the second preset temperature requirement range. It can be understood that the second preset temperature requirement range and the first preset temperature range may be the same or different. The first temperature control assembly 210 and the second temperature control assembly can respectively regulate the temperatures in the thermal insulation chamber 110 and the dispensing chamber 120, such that the temperatures in the thermal insulation chamber 110 and the dispensing chamber 120 respectively meet the first preset temperature requirement range and the second preset temperature requirement range. The second temperature control assembly can include a second temperature regulator and a second heat exchanger connected to the second temperature regulator. The second temperature regulator is configured to regulate its own temperature, and the second heat exchanger is configured to exchange heat in the dispensing chamber 120, thereby maintaining the temperature in the dispensing chamber 120 and thus maintaining the temperature of the liquid in the dispensing bags 310. The second temperature control assembly can also only include the second temperature regulator which directly exchanges heat in the dispensing chamber 120, thereby maintaining the temperature in the dispensing chamber 120 and thus controlling the temperature of the liquid in the dispensing bags 310. The second temperature regulator can adjust the temperature through means such as compressor cooling and semiconductor cooling. In an embodiment, the second temperature regulator adjusts the temperature through semiconductor cooling, thereby achieving temperature maintenance while reducing costs. In an embodiment, the second temperature regulator exchanges heat with the liquid in the dispensing bags 310 by directly contacting the dispensing bags 310, thereby more efficiently maintaining the temperature of the liquid in the dispensing bags 310.

[0019] In an embodiment, the housing 100 further includes a temperature control channel (not shown) communicating between the thermal insulation chamber 110 and the dispensing chamber 120. The temperature control mechanism 200 further includes a temperature transmission assembly (not shown) arranged in the temperature control channel and configured to control heat exchange between the thermal insulation chamber 110 and the dispensing chamber 120. In this embodiment, the dispensing bags 310 in the dispensing chamber 120 can be thermally insulated by the temperature transmission assembly arranged in the temperature control channel. The temperature control channel may include an air duct communicating between the thermal insulation chamber 110 and the dispensing chamber 120, and the temperature transmission assembly may include a fan or the like arranged in the air duct. Furthermore, the fan can drive cold air from the thermal insulation chamber 110 into the dispensing chamber 120, thereby ensuring that the dispensing chamber 120 meets the corresponding second preset temperature requirement range. By controlling an air volume of the fan or an on / off state of the air duct, an amount of cold air entering the dispensing chamber 120 from the thermal insulation chamber 110 can also be controlled, ensuring that the temperatures in the thermal insulation chamber 110 and the dispensing chamber 120 respectively meet the first preset temperature requirement range and the second preset temperature requirement range. The temperature control channel may also include a channel communicating between the thermal insulation chamber 110 and the dispensing chamber 120, and the temperature transmission assembly may include a heat pipe or the like arranged in the channel. Furthermore, the heat pipe can facilitate heat exchange between the thermal insulation chamber 110 and the dispensing chamber 120, ensuring that the dispensing chamber 120 meets the corresponding second preset temperature requirement range. By controlling the heat transfer amount of the heat pipe (such as a flow rate of a refrigerant in the heat pipe) or an on / off state of the heat pipe, the amount of cold air entering the dispensing chamber 120 from the thermal insulation chamber 110 can also be controlled, ensuring that the temperatures in the thermal insulation chamber 110 and the dispensing chamber 120 respectively meet the first preset temperature requirement range and the second preset temperature requirement range.

[0020] In one embodiment of the present disclosure, while the second temperature control assembly is mounted in the dispensing chamber 120, the temperature of the dispensing bags 310 in the dispensing chamber 120 may also be adjusted by the temperature transmission assembly mounted in the temperature control channel, thereby controlling the temperature of the liquid in the dispensing bags 310 to meet the second preset temperature requirement range. The specific settings can refer to the descriptions in the above embodiment, which are not repeated herein.

[0021] As shown in FIG. 2, in one embodiment, the temperature control mechanism 200 further includes thermal insulation cotton 220 covering an inner wall of the thermal insulation chamber 110, and a thermal insulation board 230 mounted on a chamber door of the thermal insulation chamber 110. An insulated space for thermally insulating the to-be-dispensed container 111 contained in the thermal insulation chamber 110 is formed between the thermal insulation board 230 and the thermal insulation cotton 220. It can be understood that the thermal insulation chamber 110 includes the chamber door provided with the thermal insulation board 230. The insulated space for thermally insulating the to-be-dispensed container 111 contained in the thermal insulation chamber 110 is formed between the thermal insulation board 230 and the thermal insulation cotton 220. The thermal insulation cotton 220 can be arranged to partially or fully cover the inner wall of the thermal insulation chamber 110. The thermal insulation cotton 220 and the thermal insulation board 230 can block heat exchange between the thermal insulation chamber 110 and the exterior of the thermal insulation chamber 110, preventing energy dissipation to the exterior of the thermal insulation chamber 110. This facilitates maintaining the cooling temperature of the liquid in the to-be-dispensed container 111, thereby improving temperature regulation efficiency and reducing energy consumption. Furthermore, both the chamber door and the thermal insulation board 230 can be made of transparent material, facilitating observation of the mixing state of the to-be-dispensed container 111.

[0022] In an embodiment, the liquid dispensing device further includes a heat dissipation assembly (not shown) arranged on the housing 100 and configured to dissipate heat generated by the temperature control mechanism 200. The heat dissipation assembly includes a heat dissipation channel arranged on the housing 100, through which the temperature control mechanism 200 can exchange heat with the external environment. The heat dissipation assembly further includes a fan arranged in the heat dissipation channel and configured to discharge the heat generated by the temperature control mechanism 200. The fan can accelerate the heat exchange between the temperature control mechanism 200 and the external environment. It can be understood that the temperature control mechanism 200 generates heat while cooling down, and the heat dissipation assembly can timely transfer the above heat out of the liquid dispensing device, thereby ensuring the rapid cooling effect of the temperature control mechanism 200.

[0023] In one embodiment, a drainage groove (not shown) is provided at a bottom of the thermal insulation chamber 110 to prevent water accumulation caused by condensed water or liquid leakage from the to-be-dispensed container 111. A silicone sealing strip is provided at the position corresponding to the chamber door of the thermal insulation chamber 110 to seal a mounting gap of the chamber door on the thermal insulation chamber 110. A fiberglass pad is also provided on the chamber door to isolate the first heat exchanger 212 and the thermal insulation board 230, preventing direct contact therebetween, thereby further preventing energy in the thermal insulation chamber 110 from dissipating to the exterior of the thermal insulation chamber 110.

[0024] As shown in FIG. 2, in an embodiment, the temperature control mechanism 200 further includes a temperature sensor 240 arranged in the thermal insulation chamber 110 and configured to detect the temperature in the thermal insulation chamber 110. It can be understood that the temperature sensor 240 is connected to the temperature control mechanism 200 and configured to transmit a temperature data set to the temperature control mechanism 200. The temperature sensor 240 includes at least one first temperature sensor arranged in the thermal insulation chamber 110 and a second temperature sensor arranged on the first temperature control assembly 210. The real-time temperature includes a first real-time temperature measured by any one of the first temperature sensor and a second real-time temperature measured by the second temperature sensor arranged on the first temperature control assembly 210. In this embodiment, the temperature data set may include only the first real-time temperature measured by the first temperature sensor of the thermal insulation chamber 110, only the second real-time temperature measured by the second temperature sensor , or both the second real-time temperature and one or more first real-time temperatures, as long as all the real-time temperatures in the temperature data set meet the first preset temperature requirement range. In this embodiment of the present disclosure, meeting the first preset temperature requirement range may mean that each real-time temperature in the temperature data set reaches the corresponding first preset temperature requirement range, or may mean that an average value of all the real-time temperatures reaches the corresponding first preset temperature requirement range. The first preset temperature requirement range may refer to the required temperature range (such as 1 to 25 degrees) for storing the cell preparations.

[0025] As shown in FIG. 3, in one embodiment, the liquid path mechanism 400 includes a driving assembly 420 configured to drive the liquid in the to-be-dispensed container 111 into the dispensing mechanism 300. The driving assembly 420 includes a first driving pump 421 configured to drive the liquid in the to-be-dispensed container 111 into the dispensing mechanism 300, a first switch valve 422 configured to control on / off of the pipeline between the to-be-dispensed container 111 and the dispensing mechanism 300, and a third bubble sensor 423 configured to monitor a flow state of the liquid between the to-be-dispensed container 111 and the dispensing mechanism 300 in real time. The first driving pump 421, the first switch valve 422, and the third bubble sensor 423 are all mounted on the housing 100.

[0026] In this embodiment, the first transfer pipeline is mounted on the first driving pump 421, the first switch valve 422, and the third bubble sensor 423. The first driving pump 421 is configured to drive the liquid in the to-be-dispensed container 111 to flow towards the dispensing mechanism 300 through the first transfer pipeline. The first switch valve 422 is configured to control the on / off of the first transfer pipeline between the to-be-dispensed container 111 and the dispensing mechanism 300. The third bubble sensor 423 is configured to monitor the flow state of the liquid in the first transfer pipeline between the to-be-dispensed container 111 and the dispensing mechanism 300 in real time.

[0027] It can be understood that the first driving pump 421 includes, but is not limited to, a pump that can drive fluid flow, such as a peristaltic pump. The peristaltic pump used in the first driving pump 421 can be determined according to a dispensing volume of the liquid to be transferred. For example, in the embodiment shown in FIG. 3, the first driving pump 421 includes a large peristaltic pump and a small peristaltic pump. Thus, a small peristaltic pump can be used when the dispensing volume of the liquid to be transferred is relatively small, and a large peristaltic pump can be used when the dispensing volume of the liquid to be transferred is relatively large. The peristaltic pump delivers fluid by alternately squeezing and releasing an elastic delivery hose of the peristaltic pump. The peristaltic pump can rotate in either forward or reverse direction to drive fluid (either gas or liquid) to flow in different directions.

[0028] It can be understood that gas may be present in the consumable tube set during initial use. When the first driving pump 421 drives the liquid in the container 111 to flow towards the dispensing mechanism 300 through the first transfer pipeline, gas may be injected into the dispensing bag 310. In addition, a certain amount of gas may also be present in the dispensing bag 310 before use. Therefore, the first driving pump 421 can also be used to perform an air extraction operation on each of the dispensing bags 310 in the dispensing mechanism 300. That is, after inputting a preset volume of liquid into the dispensing bag 310, the first driving pump 421 can also extract air from each of the dispensing bags 310 in the dispensing mechanism 300 by reverse direction or other methods, thereby improving the dispensing effect.

[0029] In an embodiment, the dispensing mechanism 300 further includes an air pressure sensor (not shown) arranged in the first transfer pipeline and configured to detect an air pressure in the first transfer pipeline. Furthermore, the air pressure sensor is arranged in an end of the first transfer pipeline away from the to-be-dispensed container 111. It can be understood that the first transfer pipeline communicates with the dispensing bag 310, and by arranging the air pressure sensor in the first transfer pipeline, the air pressure in the dispensing bag 310 can be detected. When air is extracted from the dispensing bag 310 through the first transfer pipeline, the air pressure sensor detects the air pressure in the first transfer pipeline, such that an air extraction state of the dispensing bag 310 and the airtightness of the dispensing bag 310 can be detected.

[0030] As shown in FIG. 1, in one embodiment, the housing 100 is provided with a mounting portion for mounting a sample container 600. The driving assembly 420 further includes a second driving pump 424 configured to drive the liquid in the sample container 600 to flow into the to-be-dispensed container 111, and a second switch valve 425 for controlling on / off of the pipeline communicating the to-be-dispensed container 111 or / and the dispensing mechanism 300 with the external environment. Both the second driving pump 424 and the second switch valve 425 are mounted on the housing 100, and the third bubble sensor 423 is further configured to monitor a flow state of the liquid between the sample container 600 and the to-be-dispensed container 111 in real time. The sample container 600 can be a container such as a liquid bag for holding sample liquid (such as various cell preparations that need to be dispensed). It can be understood that before dispensing the liquid, the sample container 600 needs to be in communication with the to-be-dispensed container 111, such that the sample liquid is greater than or equal to the total dispensing volume (the total dispensing volume is the volume of liquid that needs to be dispensed into all dispensing bags 310 of the dispensing mechanism 300 in the current dispensing process) is input from the sample container 600 into the to-be-dispensed container 111, thereby ensuring that the liquid can be dispensed into all dispensing bags 310 of the dispensing mechanism 300 and meeting the dispensing volume requirements.

[0031] In this embodiment, the sample container 600 communicates with the to-be-dispensed container 111 through the second transfer pipeline in the consumable tube set. The to-be-dispensed container 111 and / or the dispensing mechanism 300 communicate with the external environment through a gas pipeline in the consumable tube set. Furthermore, one end of the second transfer pipeline away from the sample container 600 communicates with the first transfer pipeline. The second transfer pipeline is mounted on the second driving pump 424, thereby driving the liquid in the sample container 600 to flow into the to-be-dispensed container 111. One end of the gas pipeline communicates with the first transfer pipeline, and the gas pipeline is mounted on the second switch valve 425, thereby controlling the on / off of the pipeline communicating the to-be-dispensed container 111 and / or the dispensing mechanism 300 with the external environment.

[0032] It can be understood that the second driving pump 424 includes, but is not limited to, a pump such as a peristaltic pump that can drive fluid flow. The peristaltic pump used in the second driving pump 424 can be determined based on the total dispensing volume of the liquid to be transferred. For example, a small peristaltic pump can be used when the total dispensing volume of the liquid to be transferred is relatively small, and a large peristaltic pump can be used when the total dispensing volume of the liquid to be transferred is relatively large. The peristaltic pump delivers fluid by alternately squeezing and releasing an elastic delivery hose of the peristaltic pump. The peristaltic pump can rotate in either forward or reverse direction to drive fluid (gas or liquid) to flow in different directions.

[0033] As shown in FIGS. 1 and 3, in one embodiment, positions on the first driving pump 421, the first switch valve 422, the third bubble sensor 423, the second driving pump 424, and the second switch valve 425 for mounting the pipelines are all located on the same surface of the housing 100, thus facilitating operation and use.

[0034] In one embodiment, a sterile filter is provided at an end of the gas pipeline away from the first transfer pipeline, thereby preventing bacteria and other contaminants from the external atmosphere from entering the consumable tube set.

[0035] As shown in FIG. 3, in one embodiment, the liquid path mechanism 400 includes a quantifying assembly 410 for detecting a real-time flow rate of the liquid flowing from the to-be-dispensed container 111 into the dispensing mechanism 300. The quantifying assembly 410 includes a quantifying tube 411, a first bubble sensor 412, and a second bubble sensor 413 respectively arranged at both ends of the quantifying tube 411. The quantifying tube 411, the first bubble sensor 412, and the second bubble sensor 413 are all mounted on the housing 100.

[0036] In this embodiment, the first transfer pipeline is mounted on the first bubble sensor 412, the quantifying tube 411, and the second bubble sensor 413. The quantifying tube 411 can be a container with an internal space or a fixed pipeline. A quantitative space is provided between the first bubble sensor 412 and the second bubble sensor 413, which includes an internal space of the quantifying tube 411, a space between the first bubble sensor 412 and the quantifying tube 411, and a space between the quantifying tube 411 and the second bubble sensor 413.

[0037] It can be understood that the quantifying assembly 410 can accurately detect the real-time flow rate of the sample liquid flowing into the dispensing mechanism 300 based on a multi-mode sensor data fusion algorithm, that is, the real-time flow rate of the first driving pump 421. In an embodiment, detecting the real-time flow rate of the sample liquid flowing into the dispensing mechanism 300 through the quantifying assembly 410 includes steps as follows.

[0038] S10, detecting a first time point when liquid flows into the quantitative space through the first bubble sensor 412, wherein the quantitative space refers to a flowing space in the first transfer pipeline located between the first bubble sensor 412 and the second bubble sensor 413, and the quantitative space includes the internal space of the quantifying tube 411. That is, the first time point when the liquid enters the quantitative space can be determined by the first bubble sensor 412.

[0039] S20, detecting a second time point when liquid flows out of the quantitative space through the second bubble sensor 413. That is, the second time point when the liquid exits the quantitative space can be determined by the second bubble sensor 413.

[0040] S30, obtaining a volume of the quantitative space, and determining the real-time flow rate based on the volume of the quantitative space, the first time point, and the second time point. That is, a time difference between the first time point and the second time point is first calculated, and then the volume of the quantitative space is divided by the time difference to determine the current real-time flow rate of the first driving pump 421. It can be understood that during the transfer of the liquid, if the liquid is a cell preparation, due to different densities and sizes of different cells in different liquids, a flow velocity of the liquid in the first transfer pipeline (a quotient of the real-time flow rate of the first driving pump 421 and a cross-sectional area of the first transfer pipeline) may affect the survival rate of the cells. Therefore, an initial flow rate can be preset based on parameters of the liquid (including the liquid type) and parameters of the first transfer pipeline (including the cross-sectional area of the first transfer pipeline), such that the liquid flows at an initial speed to ensure cell viability. Therefore, the first driving pump 421 can be controlled to operate at the initial flow rate, thereby driving the liquid to flow at the initial speed. However, in actual liquid transfer process, the first driving pump 421 cannot operate precisely at the initial flow rate, and there will inevitably be some errors. Therefore, for the present disclosure, it is necessary to determine a volume of the liquid currently entering the dispensing mechanism 300 based on the real-time flow rate. Since the dispensing amount of the liquid entering each dispensing bag 310 during the dispensing process is closely related to this volume, it is necessary to further determine the actual variation of the initial flow rate, that is, to accurately determine the real-time flow rate through the quantifying assembly 410, thereby ensuring the accuracy of the dispensing amount of liquid entering each dispensing bag 310 and improving the dispensing precision.

[0041] In an embodiment, the liquid dispensing device further includes a mixing mechanism 500 mounted in the thermal insulation chamber 110. The mixing mechanism 500 includes a mounting plate 510 and a mixing assembly 520. The to-be-dispensed container 111 is mounted on the mounting plate 510, and the mixing assembly 520 is mounted on the mounting plate 510 and configured to mix the liquid in the to-be-dispensed container 111. It can be understood that the aforementioned mixing process may refer to mixing the liquid in the to-be-dispensed container 111 according to preset mixing parameters (including but not limited to a mixing frequency, a mixing amplitude, a mixing speed, a mixing acceleration, etc.). The mounting plate 510 can be mounted on the inner wall of the thermal insulation chamber 110.

[0042] As shown in FIGS. 4 and 5, in one embodiment, the mixing assembly 520 includes a linear motion assembly 521 mounted on the mounting plate 510, and a mixing plate 522 connected to the linear motion assembly 521 and arranged opposite to the to-be-dispensed container 111. The mixing plate 522 pats or compresses the to-be-dispensed container 111 under the driving of the linear motion assembly 521, thereby mixing the liquid in the container 111. It can be understood that the mixing plate 522 can be arranged opposite to the first temperature control assembly 210, with the to-be-dispensed container 111 located between the mixing plate 522 and the first temperature control assembly 210. The linear motion assembly 521 is configured to output linear motion to the mixing plate 522, such that the mixing plate 522 compresses or pats the to-be-dispensed container 111 arranged between the mixing plate 522 and the first temperature control assembly 210, causing the liquid in the container 111 to flow upward and then sink down. This allows for cooling of the liquid in the to-be-dispensed container 111 while mixing the liquid in the to-be-dispensed container 111.

[0043] As shown in FIGS. 4 and 5, in one embodiment, the mounting plate 510 is provided with a guiding hole. The linear motion assembly 521 includes a driving wheel 5211, a driven wheel 5212, a motor 5213 connected to the driving wheel 5211 and configured to drive the driving wheel 5211 to rotate, a timing belt 5214 sleeved on the driving wheel 5211 and the driven wheel 5212, a connecting block 5215 connected to the timing belt 5214, and a guiding shaft 5216 connected to the connecting block 5215. One end of the guiding shaft 5216 away from the connecting block 5215 passes through the guiding hole and is connected to the mixing plate 522. It can be understood that the motor 5213 is configured to drive the driving wheel 5211 to rotate the timing belt 5214, which in turn drives the connecting block 5215, the guiding shaft 5216, and the mixing plate 522 to move linearly along the guiding hole, such that the mixing plate 522 moves towards or away from the dispensing bag 310 mounted on the mounting plate 510, thereby achieving the patting or compressing of the dispensing bag 310 and thus mixing the liquid in the dispensing bag 310.

[0044] As shown in FIGS. 4 and 5, in one embodiment, the linear motion assembly 521 further includes a linear bearing 5217 sleeved in the guiding hole. The guiding shaft 5216 is slidably connected to the guiding hole through the linear bearing 5217. Furthermore, an inner wall of the linear bearing 5217 is provided with balls, and the linear bearing 5217 is arranged between the guiding hole and the guiding shaft 5216. When moving in the linear bearing 5217 along a guiding direction, the guiding shaft 5216 can roll with the balls, thereby reducing a friction force between the guiding hole and the guiding shaft 5216 during smooth movement, further reducing heat generation, and simultaneously achieving smooth linear motion with high sensitivity and precision.

[0045] As shown in FIGS. 4 and 5, in one embodiment, the guiding shaft 5216 includes a first guiding shaft 5218 and a second guiding shaft 5219. One end of the mixing plate 522 is rotatably connected to the first guiding shaft 5218, and the other end of the mixing plate 522 is detachably connected to the second guiding shaft 5219. In this embodiment, the to-be-dispensed container 111 is located between the mounting plate 510 and the mixing plate 522. To facilitate the access and placement of the to-be-dispensed container 111, one end of the mixing plate 522 is rotatably connected to the first guiding shaft 5218, and the other end of the mixing plate 522 is detachably connected to the second guiding shaft 5219. Thus, after the mixing plate 522 is detached from the second guiding shaft 5219, the mixing plate 522 can rotate relative to the first guiding shaft 5218, forming a larger access and placement space, thereby facilitating the access and placement of the to-be-dispensed container 111. It can be understood that the rotatable connection method includes but is not limited to hinge connection, bearing connection, or rotational plug-in connection. Furthermore, one end of the mixing plate 522 is rotatably connected to the first guiding shaft 5218 through a torque hinge, such that the mixing plate 522 can remain at a fixed position after being opened without affecting the access and placement of the to-be-dispensed container 111. The detachable connection method includes but is not limited to snap connection, interference fit, or pin connection. Furthermore, the other end of the mixing plate 522 is detachably connected to the second guiding shaft 5219 through a knob snap, stabilizing the connection between the mixing plate 522 and the second guiding shaft 5219 while facilitating disassembly.

[0046] As shown in FIG. 1, in one embodiment, the dispensing mechanism 300 includes a dispensing switch valve 320 arranged at an entrance of each dispensing bag 310 and configured to control opening and closing of the entrance of the dispensing bag 310. It can be understood that an input pipeline can be arranged at the entrance of the dispensing bag 310, and the dispensing switch valve 320 can be arranged on the input pipeline. After the dispensing switch valve 320 is opened, liquid can flow into the dispensing bag 310. When the dispensing bag 310 reaches the dispensing volume, the dispensing switch valve 320 is closed, thereby ensuring that all dispensing bags 310 meet the dispensing volume requirement. In addition, after the dispensing operation is completed, the input pipeline can be cut off by heat sealing, and then a replaced dispensing bag 310 can be heat sealed into the dispensing pipeline by a sterile tube connecting machine, such that the next round of dispensing operation can be performed.

[0047] The above descriptions are only optional embodiments of the application, and do not limit the scope of the patents of the present disclosure. All the equivalent structural transformations made by the content of the specification and drawings of the present disclosure under the creative concept of the present disclosure, or directly / indirectly used in other related technical fields are all comprised in the protection scope of the patents of the present disclosure.

Examples

Embodiment Construction

[0010]To make the objectives, technical solutions, and advantages of the present disclosure clearer, the technical solutions of the present disclosure will be clearly and comprehensively described below in conjunction with the accompanying drawings. It is apparent that the described embodiments are a part of the embodiments of the present disclosure, not all embodiments. Based on the embodiments of the present disclosure, all other embodiments obtained by those of ordinary skill in the art without creative effort fall in the scope of protection of the present disclosure.

[0011]It should be understood that orientation or position relationships indicated by the terms such as "up", "down", "left", "right", "front", "back", and "middle" are based on orientation or position relationships shown in the accompanying drawings, and are used only for ease of description of the present disclosure and brevity of the description, rather than indicating or implying that the mentioned apparatus or e...

[0001] This application claims priority to the Chinese patent application with application number 202311439941.0, filed with the China National Intellectual Property Administration on October 31, 2023, titled "Liquid Dispensing Device", the entire contents of which are incorporated herein by reference into the present disclosure.TECHNICAL FIELD

[0002] The present disclosure relates to the field of biomedical technology, and more particularly, to a liquid dispensing device.BACKGROUND

[0003] Cell preparation dispensing technology is an important component of the biomedical technology field and is crucial for cell therapy and pharmaceutical preparation. If stable and high-precision dispensing requirements cannot be satisfied, the therapeutic effect of cell preparations may be affected and the treatment opportunity for patients may be delayed. In existing technologies, the liquid volume measurement during dispensing is typically implemented using devices and methods such as manually starting and stopping peristaltic pumps, weighing, and manual recording. The inventor has realized that the above methods are slow in dispensing speed and cannot quickly dispense large doses of cell preparation products into dispensing bags in a short time. In addition, due to the slow dispensing speed during the dispensing process, the integrity and viability of the cell preparations may be damaged by temperature changes, thereby reducing the dispensing quality.SUMMARY OF THE DISCLOSURE

[0004] The present disclosure provides a liquid dispensing device to address the issues of slow dispensing speed and low dispensing quality in existing liquid dispensing devices.

[0005] The dispensing device provided in an embodiment of the present disclosure includes: a housing internally partitioned to form a thermal insulation chamber for accommodating a to-be-dispensed container and maintaining a temperature of the to-be-dispensed container, as well as a dispensing chamber configured to accommodate multiple dispensing bags; a temperature control mechanism including a first temperature control assembly mounted in the thermal insulation chamber and configured to regulate a temperature in the thermal insulation chamber; a dispensing mechanism mounted in the dispensing chamber and configured to dispense liquid in the to-be-dispensed container into the dispensing bags; and a liquid path mechanism mounted on the housing and configured to dispense liquid in the to-be-dispensed container into the dispensing bags through the dispensing mechanism.

[0006] The present disclosure utilizes the liquid path mechanism to dispense the liquid from the to-be-dispensed container into the multiple dispensing bags through the dispensing mechanism, thereby achieving rapid liquid dispensing and improving the liquid dispensing speed. The present disclosure further provides the thermal insulation chamber and the dispensing chamber in a partitioned manner in the housing. The temperature in the thermal insulation chamber is controlled by the temperature control mechanism, while the dispensing chamber can protect the dispensing bags and also provide a thermal insulation effect, thus maintaining the temperature of the cell preparations within the preset temperature range. This avoids damage to the integrity and viability of the cell preparations due to improper temperature, and improves the liquid dispensing quality. The present disclosure improves both the liquid dispensing speed and the liquid dispensing quality, thereby improving the liquid dispensing efficiency.

[0007] The details of one or more embodiments of the present disclosure are presented in the accompanying drawings and descriptions below, and other features and advantages of the present disclosure will become apparent from the specification, drawings, and claims.BRIEF DESCRIPTION OF THE DRAWINGS

[0008] The present disclosure will be further described below in conjunction with the accompanying drawings and embodiments. FIG. 1 is a schematic view of a liquid dispensing device in accordance with an embodiment of the present disclosure. FIG. 2 is a schematic view of a temperature control mechanism in accordance with an embodiment of the present disclosure. FIG. 3 is a schematic view of a liquid path mechanism in accordance with an embodiment of the present disclosure. FIG. 4 is a schematic view of a mixing mechanism in accordance with an embodiment of the present disclosure. FIG. 5 is a schematic view of a mixing mechanism in accordance with another embodiment of the present disclosure.

[0009] Reference signs in the accompanying drawings are as follows: 110, thermal insulation chamber; 111, to-be-dispensed container; 120, dispensing chamber; 121, dispensing bag; 200, temperature control mechanism; 210, first temperature control assembly; 211, first temperature regulator; 2111, compressor; 2112, evaporator; 212, first heat exchanger; 2121, metal tube; 2122, metal sheet; 220, thermal insulation cotton; 230, thermal insulation board; 240, temperature sensor; 300, dispensing mechanism; 310, dispensing bag; 320, dispensing switch valve; 400, liquid path mechanism; 410, quantifying assembly; 411, quantifying tube; 412, first bubble sensor; 413, second bubble sensor; 420, driving assembly; 421, first driving pump; 422, first switch valve; 423, third bubble sensor; 424, second driving pump; 425, second switch valve; 500, mixing mechanism; 510, mounting plate; 520, mixing assembly; 521, linear motion assembly; 5211, driving wheel; 5212, driven wheel; 5213, motor; 5214, timing belt; 5215, connecting block; 5216, guiding shaft; 5217, linear bearing; 5218, first guiding shaft; 5219, second guiding shaft; 522, mixing plate; 600, sample container.PREFERRED EMBODIMENTS

[0010] To make the objectives, technical solutions, and advantages of the present disclosure clearer, the technical solutions of the present disclosure will be clearly and comprehensively described below in conjunction with the accompanying drawings. It is apparent that the described embodiments are a part of the embodiments of the present disclosure, not all embodiments. Based on the embodiments of the present disclosure, all other embodiments obtained by those of ordinary skill in the art without creative effort fall in the scope of protection of the present disclosure.

[0011] It should be understood that orientation or position relationships indicated by the terms such as "up", "down", "left", "right", "front", "back", and "middle" are based on orientation or position relationships shown in the accompanying drawings, and are used only for ease of description of the present disclosure and brevity of the description, rather than indicating or implying that the mentioned apparatus or element needs to have a particular orientation or be constructed and operated in a particular orientation. Therefore, such terms should not be construed as a limitation on the present disclosure.

[0012] As shown in FIG. 1 and FIG. 2, an embodiment of the present disclosure provides a liquid dispensing device, including a housing 100, a temperature control mechanism 200, a dispensing mechanism 300, and a liquid path mechanism 400.

[0013] The housing 100 is internally partitioned to form a thermal insulation chamber 110 for accommodating a to-be-dispensed container 111 and thermally insulating the to-be-dispensed container 111, and a dispensing chamber 120 for accommodating a plurality of dispensing bags 310. In this embodiment, as shown in FIG. 1, the to-be-dispensed container 111 for accommodating liquid is mounted in the thermal insulation chamber 110, and a plurality of dispensing bags 310 are mounted in the dispensing chamber 120. Meanwhile, after a consumable tube set for transmitting fluids (including gases and liquids) is mounted on the liquid dispensing device, the liquid in the to-be-dispensed container 111 can be dispensed. In this embodiment, after the dispensing operation is completed, the next round of dispensing operation can be performed by replacing the consumable tube set, the to-be-dispensed container 111, and the dispensing bags 310, or by directly replacing the dispensing bags 310 (for example, by cutting off an inlet of the dispensing bag 310 through heat sealing, and then heat sealing the replaced dispensing bag 310 to the inlet through a sterile tube welder), thereby improving the dispensing efficiency. In an embodiment, the to-be-dispensed container 111 can communicate with a plurality of the dispensing bags 310 in the dispensing mechanism 300 through a first transfer pipeline in the consumable tube set. After the to-be-dispensed container 111 is placed in the thermal insulation chamber 110, the dispensing bags 310 are mounted in the dispensing chamber 120, and the first transfer pipeline is mounted in the liquid path mechanism 400, the liquid in the to-be-dispensed container 111 can be driven by the liquid path mechanism 400 to be dispensed into the dispensing bags 310 in the dispensing mechanism 300 through the dispensing mechanism 300.

[0014] The temperature control mechanism 200 includes a first temperature control assembly 210 arranged in the thermal insulation chamber 110 and configured to regulate a temperature in the thermal insulation chamber 110. It can be understood that the liquid dispensing device is generally configured to dispense cell preparations, such that the liquid in the to-be-dispensed container 111 is generally a cell preparation. To avoid damaging the integrity and viability of the cell preparation, the cell preparation needs to be stored in a first preset temperature requirement range. The first temperature control assembly 210 may include a first temperature regulator 211 and a first heat exchanger 212 connected to the first temperature regulator 211. The first temperature regulator 211 is configured to regulate its own temperature, and the first heat exchanger 212 is configured to exchange heat in the thermal insulation chamber 110, thereby regulating the temperature in the thermal insulation chamber 110 and controlling a temperature of the liquid in the to-be-dispensed container 111 to meet the first preset temperature requirement range. The first temperature control assembly 210 may only include the first temperature regulator 211, which directly exchanges heat in the thermal insulation chamber 110, thereby regulating the temperature in the thermal insulation chamber 110 and controlling the temperature of the liquid in the to-be-dispensed container 111 to meet the first preset temperature requirement range. The first temperature regulator 211 can perform temperature regulation through means such as compressor cooling and semiconductor cooling. In one embodiment, the first temperature regulator 211 performs temperature regulation through compressor cooling, allowing for faster temperature adjustment. As shown in FIG. 2, the first temperature regulator 211 may include components such as a compressor 2111 and an evaporator 2112. For a specific cooling method, reference may be made to cooling methods of air conditioners and the like, and details are not repeated herein. The first heat exchanger 212 may include heat-conductive components such as a metal tube 2121 and / or a metal sheet 2122. The first heat exchanger 212 can exchange heat in a contact or non-contact manner. In one embodiment, the first heat exchanger 212 exchanges heat with the liquid in the to-be-dispensed container 111 by directly contacting the container 111, allowing for more efficient temperature adjustment of the liquid in the to-be-dispensed container 111.

[0015] The dispensing mechanism 300 is arranged in the dispensing chamber 120 and configured to dispense the liquid contained in the to-be-dispensed container 111 into the dispensing bags 310. The dispensing chamber 120 protects the dispensing bags 310 and also provides a certain level of thermal insulation for the cell preparations contained in the dispensing bags 310.

[0016] The liquid path mechanism 400 is arranged on the housing 100 and configured to dispense the liquid in the to-be-dispensed container 111 into the dispensing bag 310 through the dispensing mechanism 300.

[0017] The present disclosure utilizes the liquid path mechanism 400 to dispense the liquid in the to-be-dispensed container 111 into multiple dispensing bags 310 through the dispensing mechanism 300, thereby achieving rapid liquid dispensing and improving liquid dispensing speed. The present disclosure further provides the thermal insulation chamber 110 and the dispensing chamber 120 in a partitioned manner in the housing 100. The temperature control mechanism 200 controls the temperature in the thermal insulation chamber 110, while the dispensing chamber 120 can protect the dispensing bags 310 and also provide a certain thermal insulation function, thereby maintaining the temperature of the cell preparations within a preset temperature range (including the first preset temperature range mentioned above and the second preset temperature range mentioned later), avoiding damage to the integrity and viability of the cell preparations due to improper temperature, and improving the liquid dispensing quality. The present disclosure improves both the liquid dispensing speed and the liquid dispensing quality, thereby improving the liquid dispensing efficiency.

[0018] In an embodiment, the temperature control mechanism 200 further includes a second temperature control assembly (not shown) arranged in the dispensing chamber 120 and configured to regulate a temperature in the dispensing chamber 120. In this embodiment, the temperature of the dispensing bags 310 in the dispensing chamber 120 can be adjusted by arranging the second temperature control assembly in the dispensing chamber 120, thereby controlling the temperature of the liquid in the dispensing bags 310 to meet the second preset temperature requirement range. It can be understood that the second preset temperature requirement range and the first preset temperature range may be the same or different. The first temperature control assembly 210 and the second temperature control assembly can respectively regulate the temperatures in the thermal insulation chamber 110 and the dispensing chamber 120, such that the temperatures in the thermal insulation chamber 110 and the dispensing chamber 120 respectively meet the first preset temperature requirement range and the second preset temperature requirement range. The second temperature control assembly can include a second temperature regulator and a second heat exchanger connected to the second temperature regulator. The second temperature regulator is configured to regulate its own temperature, and the second heat exchanger is configured to exchange heat in the dispensing chamber 120, thereby maintaining the temperature in the dispensing chamber 120 and thus maintaining the temperature of the liquid in the dispensing bags 310. The second temperature control assembly can also only include the second temperature regulator which directly exchanges heat in the dispensing chamber 120, thereby maintaining the temperature in the dispensing chamber 120 and thus controlling the temperature of the liquid in the dispensing bags 310. The second temperature regulator can adjust the temperature through means such as compressor cooling and semiconductor cooling. In an embodiment, the second temperature regulator adjusts the temperature through semiconductor cooling, thereby achieving temperature maintenance while reducing costs. In an embodiment, the second temperature regulator exchanges heat with the liquid in the dispensing bags 310 by directly contacting the dispensing bags 310, thereby more efficiently maintaining the temperature of the liquid in the dispensing bags 310.

[0019] In an embodiment, the housing 100 further includes a temperature control channel (not shown) communicating between the thermal insulation chamber 110 and the dispensing chamber 120. The temperature control mechanism 200 further includes a temperature transmission assembly (not shown) arranged in the temperature control channel and configured to control heat exchange between the thermal insulation chamber 110 and the dispensing chamber 120. In this embodiment, the dispensing bags 310 in the dispensing chamber 120 can be thermally insulated by the temperature transmission assembly arranged in the temperature control channel. The temperature control channel may include an air duct communicating between the thermal insulation chamber 110 and the dispensing chamber 120, and the temperature transmission assembly may include a fan or the like arranged in the air duct. Furthermore, the fan can drive cold air from the thermal insulation chamber 110 into the dispensing chamber 120, thereby ensuring that the dispensing chamber 120 meets the corresponding second preset temperature requirement range. By controlling an air volume of the fan or an on / off state of the air duct, an amount of cold air entering the dispensing chamber 120 from the thermal insulation chamber 110 can also be controlled, ensuring that the temperatures in the thermal insulation chamber 110 and the dispensing chamber 120 respectively meet the first preset temperature requirement range and the second preset temperature requirement range. The temperature control channel may also include a channel communicating between the thermal insulation chamber 110 and the dispensing chamber 120, and the temperature transmission assembly may include a heat pipe or the like arranged in the channel. Furthermore, the heat pipe can facilitate heat exchange between the thermal insulation chamber 110 and the dispensing chamber 120, ensuring that the dispensing chamber 120 meets the corresponding second preset temperature requirement range. By controlling the heat transfer amount of the heat pipe (such as a flow rate of a refrigerant in the heat pipe) or an on / off state of the heat pipe, the amount of cold air entering the dispensing chamber 120 from the thermal insulation chamber 110 can also be controlled, ensuring that the temperatures in the thermal insulation chamber 110 and the dispensing chamber 120 respectively meet the first preset temperature requirement range and the second preset temperature requirement range.

[0020] In one embodiment of the present disclosure, while the second temperature control assembly is mounted in the dispensing chamber 120, the temperature of the dispensing bags 310 in the dispensing chamber 120 may also be adjusted by the temperature transmission assembly mounted in the temperature control channel, thereby controlling the temperature of the liquid in the dispensing bags 310 to meet the second preset temperature requirement range. The specific settings can refer to the descriptions in the above embodiment, which are not repeated herein.

[0021] As shown in FIG. 2, in one embodiment, the temperature control mechanism 200 further includes thermal insulation cotton 220 covering an inner wall of the thermal insulation chamber 110, and a thermal insulation board 230 mounted on a chamber door of the thermal insulation chamber 110. An insulated space for thermally insulating the to-be-dispensed container 111 contained in the thermal insulation chamber 110 is formed between the thermal insulation board 230 and the thermal insulation cotton 220. It can be understood that the thermal insulation chamber 110 includes the chamber door provided with the thermal insulation board 230. The insulated space for thermally insulating the to-be-dispensed container 111 contained in the thermal insulation chamber 110 is formed between the thermal insulation board 230 and the thermal insulation cotton 220. The thermal insulation cotton 220 can be arranged to partially or fully cover the inner wall of the thermal insulation chamber 110. The thermal insulation cotton 220 and the thermal insulation board 230 can block heat exchange between the thermal insulation chamber 110 and the exterior of the thermal insulation chamber 110, preventing energy dissipation to the exterior of the thermal insulation chamber 110. This facilitates maintaining the cooling temperature of the liquid in the to-be-dispensed container 111, thereby improving temperature regulation efficiency and reducing energy consumption. Furthermore, both the chamber door and the thermal insulation board 230 can be made of transparent material, facilitating observation of the mixing state of the to-be-dispensed container 111.

[0022] In an embodiment, the liquid dispensing device further includes a heat dissipation assembly (not shown) arranged on the housing 100 and configured to dissipate heat generated by the temperature control mechanism 200. The heat dissipation assembly includes a heat dissipation channel arranged on the housing 100, through which the temperature control mechanism 200 can exchange heat with the external environment. The heat dissipation assembly further includes a fan arranged in the heat dissipation channel and configured to discharge the heat generated by the temperature control mechanism 200. The fan can accelerate the heat exchange between the temperature control mechanism 200 and the external environment. It can be understood that the temperature control mechanism 200 generates heat while cooling down, and the heat dissipation assembly can timely transfer the above heat out of the liquid dispensing device, thereby ensuring the rapid cooling effect of the temperature control mechanism 200.

[0023] In one embodiment, a drainage groove (not shown) is provided at a bottom of the thermal insulation chamber 110 to prevent water accumulation caused by condensed water or liquid leakage from the to-be-dispensed container 111. A silicone sealing strip is provided at the position corresponding to the chamber door of the thermal insulation chamber 110 to seal a mounting gap of the chamber door on the thermal insulation chamber 110. A fiberglass pad is also provided on the chamber door to isolate the first heat exchanger 212 and the thermal insulation board 230, preventing direct contact therebetween, thereby further preventing energy in the thermal insulation chamber 110 from dissipating to the exterior of the thermal insulation chamber 110.

[0024] As shown in FIG. 2, in an embodiment, the temperature control mechanism 200 further includes a temperature sensor 240 arranged in the thermal insulation chamber 110 and configured to detect the temperature in the thermal insulation chamber 110. It can be understood that the temperature sensor 240 is connected to the temperature control mechanism 200 and configured to transmit a temperature data set to the temperature control mechanism 200. The temperature sensor 240 includes at least one first temperature sensor arranged in the thermal insulation chamber 110 and a second temperature sensor arranged on the first temperature control assembly 210. The real-time temperature includes a first real-time temperature measured by any one of the first temperature sensor and a second real-time temperature measured by the second temperature sensor arranged on the first temperature control assembly 210. In this embodiment, the temperature data set may include only the first real-time temperature measured by the first temperature sensor of the thermal insulation chamber 110, only the second real-time temperature measured by the second temperature sensor , or both the second real-time temperature and one or more first real-time temperatures, as long as all the real-time temperatures in the temperature data set meet the first preset temperature requirement range. In this embodiment of the present disclosure, meeting the first preset temperature requirement range may mean that each real-time temperature in the temperature data set reaches the corresponding first preset temperature requirement range, or may mean that an average value of all the real-time temperatures reaches the corresponding first preset temperature requirement range. The first preset temperature requirement range may refer to the required temperature range (such as 1 to 25 degrees) for storing the cell preparations.

[0025] As shown in FIG. 3, in one embodiment, the liquid path mechanism 400 includes a driving assembly 420 configured to drive the liquid in the to-be-dispensed container 111 into the dispensing mechanism 300. The driving assembly 420 includes a first driving pump 421 configured to drive the liquid in the to-be-dispensed container 111 into the dispensing mechanism 300, a first switch valve 422 configured to control on / off of the pipeline between the to-be-dispensed container 111 and the dispensing mechanism 300, and a third bubble sensor 423 configured to monitor a flow state of the liquid between the to-be-dispensed container 111 and the dispensing mechanism 300 in real time. The first driving pump 421, the first switch valve 422, and the third bubble sensor 423 are all mounted on the housing 100.

[0026] In this embodiment, the first transfer pipeline is mounted on the first driving pump 421, the first switch valve 422, and the third bubble sensor 423. The first driving pump 421 is configured to drive the liquid in the to-be-dispensed container 111 to flow towards the dispensing mechanism 300 through the first transfer pipeline. The first switch valve 422 is configured to control the on / off of the first transfer pipeline between the to-be-dispensed container 111 and the dispensing mechanism 300. The third bubble sensor 423 is configured to monitor the flow state of the liquid in the first transfer pipeline between the to-be-dispensed container 111 and the dispensing mechanism 300 in real time.

[0027] It can be understood that the first driving pump 421 includes, but is not limited to, a pump that can drive fluid flow, such as a peristaltic pump. The peristaltic pump used in the first driving pump 421 can be determined according to a dispensing volume of the liquid to be transferred. For example, in the embodiment shown in FIG. 3, the first driving pump 421 includes a large peristaltic pump and a small peristaltic pump. Thus, a small peristaltic pump can be used when the dispensing volume of the liquid to be transferred is relatively small, and a large peristaltic pump can be used when the dispensing volume of the liquid to be transferred is relatively large. The peristaltic pump delivers fluid by alternately squeezing and releasing an elastic delivery hose of the peristaltic pump. The peristaltic pump can rotate in either forward or reverse direction to drive fluid (either gas or liquid) to flow in different directions.

[0028] It can be understood that gas may be present in the consumable tube set during initial use. When the first driving pump 421 drives the liquid in the container 111 to flow towards the dispensing mechanism 300 through the first transfer pipeline, gas may be injected into the dispensing bag 310. In addition, a certain amount of gas may also be present in the dispensing bag 310 before use. Therefore, the first driving pump 421 can also be used to perform an air extraction operation on each of the dispensing bags 310 in the dispensing mechanism 300. That is, after inputting a preset volume of liquid into the dispensing bag 310, the first driving pump 421 can also extract air from each of the dispensing bags 310 in the dispensing mechanism 300 by reverse direction or other methods, thereby improving the dispensing effect.

[0029] In an embodiment, the dispensing mechanism 300 further includes an air pressure sensor (not shown) arranged in the first transfer pipeline and configured to detect an air pressure in the first transfer pipeline. Furthermore, the air pressure sensor is arranged in an end of the first transfer pipeline away from the to-be-dispensed container 111. It can be understood that the first transfer pipeline communicates with the dispensing bag 310, and by arranging the air pressure sensor in the first transfer pipeline, the air pressure in the dispensing bag 310 can be detected. When air is extracted from the dispensing bag 310 through the first transfer pipeline, the air pressure sensor detects the air pressure in the first transfer pipeline, such that an air extraction state of the dispensing bag 310 and the airtightness of the dispensing bag 310 can be detected.

[0030] As shown in FIG. 1, in one embodiment, the housing 100 is provided with a mounting portion for mounting a sample container 600. The driving assembly 420 further includes a second driving pump 424 configured to drive the liquid in the sample container 600 to flow into the to-be-dispensed container 111, and a second switch valve 425 for controlling on / off of the pipeline communicating the to-be-dispensed container 111 or / and the dispensing mechanism 300 with the external environment. Both the second driving pump 424 and the second switch valve 425 are mounted on the housing 100, and the third bubble sensor 423 is further configured to monitor a flow state of the liquid between the sample container 600 and the to-be-dispensed container 111 in real time. The sample container 600 can be a container such as a liquid bag for holding sample liquid (such as various cell preparations that need to be dispensed). It can be understood that before dispensing the liquid, the sample container 600 needs to be in communication with the to-be-dispensed container 111, such that the sample liquid is greater than or equal to the total dispensing volume (the total dispensing volume is the volume of liquid that needs to be dispensed into all dispensing bags 310 of the dispensing mechanism 300 in the current dispensing process) is input from the sample container 600 into the to-be-dispensed container 111, thereby ensuring that the liquid can be dispensed into all dispensing bags 310 of the dispensing mechanism 300 and meeting the dispensing volume requirements.

[0031] In this embodiment, the sample container 600 communicates with the to-be-dispensed container 111 through the second transfer pipeline in the consumable tube set. The to-be-dispensed container 111 and / or the dispensing mechanism 300 communicate with the external environment through a gas pipeline in the consumable tube set. Furthermore, one end of the second transfer pipeline away from the sample container 600 communicates with the first transfer pipeline. The second transfer pipeline is mounted on the second driving pump 424, thereby driving the liquid in the sample container 600 to flow into the to-be-dispensed container 111. One end of the gas pipeline communicates with the first transfer pipeline, and the gas pipeline is mounted on the second switch valve 425, thereby controlling the on / off of the pipeline communicating the to-be-dispensed container 111 and / or the dispensing mechanism 300 with the external environment.

[0032] It can be understood that the second driving pump 424 includes, but is not limited to, a pump such as a peristaltic pump that can drive fluid flow. The peristaltic pump used in the second driving pump 424 can be determined based on the total dispensing volume of the liquid to be transferred. For example, a small peristaltic pump can be used when the total dispensing volume of the liquid to be transferred is relatively small, and a large peristaltic pump can be used when the total dispensing volume of the liquid to be transferred is relatively large. The peristaltic pump delivers fluid by alternately squeezing and releasing an elastic delivery hose of the peristaltic pump. The peristaltic pump can rotate in either forward or reverse direction to drive fluid (gas or liquid) to flow in different directions.

[0033] As shown in FIGS. 1 and 3, in one embodiment, positions on the first driving pump 421, the first switch valve 422, the third bubble sensor 423, the second driving pump 424, and the second switch valve 425 for mounting the pipelines are all located on the same surface of the housing 100, thus facilitating operation and use.

[0034] In one embodiment, a sterile filter is provided at an end of the gas pipeline away from the first transfer pipeline, thereby preventing bacteria and other contaminants from the external atmosphere from entering the consumable tube set.

[0035] As shown in FIG. 3, in one embodiment, the liquid path mechanism 400 includes a quantifying assembly 410 for detecting a real-time flow rate of the liquid flowing from the to-be-dispensed container 111 into the dispensing mechanism 300. The quantifying assembly 410 includes a quantifying tube 411, a first bubble sensor 412, and a second bubble sensor 413 respectively arranged at both ends of the quantifying tube 411. The quantifying tube 411, the first bubble sensor 412, and the second bubble sensor 413 are all mounted on the housing 100.

[0036] In this embodiment, the first transfer pipeline is mounted on the first bubble sensor 412, the quantifying tube 411, and the second bubble sensor 413. The quantifying tube 411 can be a container with an internal space or a fixed pipeline. A quantitative space is provided between the first bubble sensor 412 and the second bubble sensor 413, which includes an internal space of the quantifying tube 411, a space between the first bubble sensor 412 and the quantifying tube 411, and a space between the quantifying tube 411 and the second bubble sensor 413.

[0037] It can be understood that the quantifying assembly 410 can accurately detect the real-time flow rate of the sample liquid flowing into the dispensing mechanism 300 based on a multi-mode sensor data fusion algorithm, that is, the real-time flow rate of the first driving pump 421. In an embodiment, detecting the real-time flow rate of the sample liquid flowing into the dispensing mechanism 300 through the quantifying assembly 410 includes steps as follows.

[0038] S10, detecting a first time point when liquid flows into the quantitative space through the first bubble sensor 412, wherein the quantitative space refers to a flowing space in the first transfer pipeline located between the first bubble sensor 412 and the second bubble sensor 413, and the quantitative space includes the internal space of the quantifying tube 411. That is, the first time point when the liquid enters the quantitative space can be determined by the first bubble sensor 412.

[0039] S20, detecting a second time point when liquid flows out of the quantitative space through the second bubble sensor 413. That is, the second time point when the liquid exits the quantitative space can be determined by the second bubble sensor 413.

[0040] S30, obtaining a volume of the quantitative space, and determining the real-time flow rate based on the volume of the quantitative space, the first time point, and the second time point. That is, a time difference between the first time point and the second time point is first calculated, and then the volume of the quantitative space is divided by the time difference to determine the current real-time flow rate of the first driving pump 421. It can be understood that during the transfer of the liquid, if the liquid is a cell preparation, due to different densities and sizes of different cells in different liquids, a flow velocity of the liquid in the first transfer pipeline (a quotient of the real-time flow rate of the first driving pump 421 and a cross-sectional area of the first transfer pipeline) may affect the survival rate of the cells. Therefore, an initial flow rate can be preset based on parameters of the liquid (including the liquid type) and parameters of the first transfer pipeline (including the cross-sectional area of the first transfer pipeline), such that the liquid flows at an initial speed to ensure cell viability. Therefore, the first driving pump 421 can be controlled to operate at the initial flow rate, thereby driving the liquid to flow at the initial speed. However, in actual liquid transfer process, the first driving pump 421 cannot operate precisely at the initial flow rate, and there will inevitably be some errors. Therefore, for the present disclosure, it is necessary to determine a volume of the liquid currently entering the dispensing mechanism 300 based on the real-time flow rate. Since the dispensing amount of the liquid entering each dispensing bag 310 during the dispensing process is closely related to this volume, it is necessary to further determine the actual variation of the initial flow rate, that is, to accurately determine the real-time flow rate through the quantifying assembly 410, thereby ensuring the accuracy of the dispensing amount of liquid entering each dispensing bag 310 and improving the dispensing precision.

[0041] In an embodiment, the liquid dispensing device further includes a mixing mechanism 500 mounted in the thermal insulation chamber 110. The mixing mechanism 500 includes a mounting plate 510 and a mixing assembly 520. The to-be-dispensed container 111 is mounted on the mounting plate 510, and the mixing assembly 520 is mounted on the mounting plate 510 and configured to mix the liquid in the to-be-dispensed container 111. It can be understood that the aforementioned mixing process may refer to mixing the liquid in the to-be-dispensed container 111 according to preset mixing parameters (including but not limited to a mixing frequency, a mixing amplitude, a mixing speed, a mixing acceleration, etc.). The mounting plate 510 can be mounted on the inner wall of the thermal insulation chamber 110.

[0042] As shown in FIGS. 4 and 5, in one embodiment, the mixing assembly 520 includes a linear motion assembly 521 mounted on the mounting plate 510, and a mixing plate 522 connected to the linear motion assembly 521 and arranged opposite to the to-be-dispensed container 111. The mixing plate 522 pats or compresses the to-be-dispensed container 111 under the driving of the linear motion assembly 521, thereby mixing the liquid in the container 111. It can be understood that the mixing plate 522 can be arranged opposite to the first temperature control assembly 210, with the to-be-dispensed container 111 located between the mixing plate 522 and the first temperature control assembly 210. The linear motion assembly 521 is configured to output linear motion to the mixing plate 522, such that the mixing plate 522 compresses or pats the to-be-dispensed container 111 arranged between the mixing plate 522 and the first temperature control assembly 210, causing the liquid in the container 111 to flow upward and then sink down. This allows for cooling of the liquid in the to-be-dispensed container 111 while mixing the liquid in the to-be-dispensed container 111.

[0043] As shown in FIGS. 4 and 5, in one embodiment, the mounting plate 510 is provided with a guiding hole. The linear motion assembly 521 includes a driving wheel 5211, a driven wheel 5212, a motor 5213 connected to the driving wheel 5211 and configured to drive the driving wheel 5211 to rotate, a timing belt 5214 sleeved on the driving wheel 5211 and the driven wheel 5212, a connecting block 5215 connected to the timing belt 5214, and a guiding shaft 5216 connected to the connecting block 5215. One end of the guiding shaft 5216 away from the connecting block 5215 passes through the guiding hole and is connected to the mixing plate 522. It can be understood that the motor 5213 is configured to drive the driving wheel 5211 to rotate the timing belt 5214, which in turn drives the connecting block 5215, the guiding shaft 5216, and the mixing plate 522 to move linearly along the guiding hole, such that the mixing plate 522 moves towards or away from the dispensing bag 310 mounted on the mounting plate 510, thereby achieving the patting or compressing of the dispensing bag 310 and thus mixing the liquid in the dispensing bag 310.

[0044] As shown in FIGS. 4 and 5, in one embodiment, the linear motion assembly 521 further includes a linear bearing 5217 sleeved in the guiding hole. The guiding shaft 5216 is slidably connected to the guiding hole through the linear bearing 5217. Furthermore, an inner wall of the linear bearing 5217 is provided with balls, and the linear bearing 5217 is arranged between the guiding hole and the guiding shaft 5216. When moving in the linear bearing 5217 along a guiding direction, the guiding shaft 5216 can roll with the balls, thereby reducing a friction force between the guiding hole and the guiding shaft 5216 during smooth movement, further reducing heat generation, and simultaneously achieving smooth linear motion with high sensitivity and precision.

[0045] As shown in FIGS. 4 and 5, in one embodiment, the guiding shaft 5216 includes a first guiding shaft 5218 and a second guiding shaft 5219. One end of the mixing plate 522 is rotatably connected to the first guiding shaft 5218, and the other end of the mixing plate 522 is detachably connected to the second guiding shaft 5219. In this embodiment, the to-be-dispensed container 111 is located between the mounting plate 510 and the mixing plate 522. To facilitate the access and placement of the to-be-dispensed container 111, one end of the mixing plate 522 is rotatably connected to the first guiding shaft 5218, and the other end of the mixing plate 522 is detachably connected to the second guiding shaft 5219. Thus, after the mixing plate 522 is detached from the second guiding shaft 5219, the mixing plate 522 can rotate relative to the first guiding shaft 5218, forming a larger access and placement space, thereby facilitating the access and placement of the to-be-dispensed container 111. It can be understood that the rotatable connection method includes but is not limited to hinge connection, bearing connection, or rotational plug-in connection. Furthermore, one end of the mixing plate 522 is rotatably connected to the first guiding shaft 5218 through a torque hinge, such that the mixing plate 522 can remain at a fixed position after being opened without affecting the access and placement of the to-be-dispensed container 111. The detachable connection method includes but is not limited to snap connection, interference fit, or pin connection. Furthermore, the other end of the mixing plate 522 is detachably connected to the second guiding shaft 5219 through a knob snap, stabilizing the connection between the mixing plate 522 and the second guiding shaft 5219 while facilitating disassembly.

[0046] As shown in FIG. 1, in one embodiment, the dispensing mechanism 300 includes a dispensing switch valve 320 arranged at an entrance of each dispensing bag 310 and configured to control opening and closing of the entrance of the dispensing bag 310. It can be understood that an input pipeline can be arranged at the entrance of the dispensing bag 310, and the dispensing switch valve 320 can be arranged on the input pipeline. After the dispensing switch valve 320 is opened, liquid can flow into the dispensing bag 310. When the dispensing bag 310 reaches the dispensing volume, the dispensing switch valve 320 is closed, thereby ensuring that all dispensing bags 310 meet the dispensing volume requirement. In addition, after the dispensing operation is completed, the input pipeline can be cut off by heat sealing, and then a replaced dispensing bag 310 can be heat sealed into the dispensing pipeline by a sterile tube connecting machine, such that the next round of dispensing operation can be performed.

[0047] The above descriptions are only optional embodiments of the application, and do not limit the scope of the patents of the present disclosure. All the equivalent structural transformations made by the content of the specification and drawings of the present disclosure under the creative concept of the present disclosure, or directly / indirectly used in other related technical fields are all comprised in the protection scope of the patents of the present disclosure.

Examples

Embodiment Construction

[0010]To make the objectives, technical solutions, and advantages of the present disclosure clearer, the technical solutions of the present disclosure will be clearly and comprehensively described below in conjunction with the accompanying drawings. It is apparent that the described embodiments are a part of the embodiments of the present disclosure, not all embodiments. Based on the embodiments of the present disclosure, all other embodiments obtained by those of ordinary skill in the art without creative effort fall in the scope of protection of the present disclosure.

[0011]It should be understood that orientation or position relationships indicated by the terms such as "up", "down", "left", "right", "front", "back", and "middle" are based on orientation or position relationships shown in the accompanying drawings, and are used only for ease of description of the present disclosure and brevity of the description, rather than indicating or implying that the mentioned apparatus or e...

Claims

1. A liquid dispensing device, comprising: a housing internally partitioned to form a thermal insulation chamber for accommodating a to-be-dispensed container and maintaining a temperature of the to-be-dispensed container, as well as a dispensing chamber configured to accommodate multiple dispensing bags; a temperature control mechanism comprising a first temperature control assembly mounted in the thermal insulation chamber and configured to regulate a temperature in the thermal insulation chamber; a dispensing mechanism mounted in the dispensing chamber and configured to dispense liquid in the to-be-dispensed container into the dispensing bags; and a liquid path mechanism mounted on the housing and configured to dispense liquid in the to-be-dispensed container into the dispensing bags through the dispensing mechanism.

2. The liquid dispensing device according to claim 1, wherein the temperature control mechanism further comprises a second temperature control assembly mounted in the dispensing chamber and configured to regulate the temperature in the dispensing chamber.

3. The liquid dispensing device according to claim 1, wherein the housing further comprises a temperature control channel communicating between the thermal insulation chamber and the dispensing chamber; the temperature control mechanism further comprises a temperature transmission assembly mounted in the temperature control channel and configured to control heat exchange between the thermal insulation chamber and the dispensing chamber.

4. The liquid dispensing device according to claim 1, wherein the temperature control mechanism further comprises thermal insulation cotton covering an inner wall of the thermal insulation chamber, and a thermal insulation board mounted on a chamber door of the thermal insulation chamber; an insulation space for maintaining the temperature of the to-be-dispensed container in the thermal insulation chamber is formed between the thermal insulation board and the thermal insulation cotton; and / or the temperature control mechanism further comprises a temperature sensor arranged in the thermal insulation chamber and configured to detect the temperature in the thermal insulation chamber.

5. The liquid dispensing device according to claim 1, wherein the liquid path mechanism comprises a quantifying assembly configured to detect a real-time flow rate of liquid flowing into the dispensing mechanism from the to-be-dispensed container; the quantifying assembly comprises a quantifying tube, and a first bubble sensor and a second bubble sensor respectively arranged at both ends of the quantifying tube; the quantifying tube, the first bubble sensor, and the second bubble sensor are all mounted on the housing.

6. The liquid dispensing device according to claim 1, wherein the liquid path mechanism comprises a driving assembly configured to drive the liquid in the to-be-dispensed container to flow into the dispensing mechanism; the driving assembly comprises a first driving pump configured to drive the liquid in the to-be-dispensed container to flow into the dispensing mechanism, a first switch valve configured to control on / off of a pipeline between the to-be-dispensed container and the dispensing mechanism, and a third bubble sensor configured to monitor a flow state of the liquid between the to-be-dispensed container and the dispensing mechanism in real time; the first driving pump, the first switch valve, and the third bubble sensor are all mounted on the housing.

7. The liquid dispensing device according to claim 1, further comprising a mixing mechanism mounted in the thermal insulation chamber; the mixing mechanism comprises a mounting plate and a mixing assembly; the to-be-dispensed container is mounted on the mounting plate, and the mixing assembly is mounted on the mounting plate and configured to mix the liquid in the to-be-dispensed container.

8. The liquid dispensing device according to claim 7, wherein the mixing assembly comprises a linear motion assembly mounted on the mounting plate, and a mixing plate connected to the linear motion assembly and disposed opposite to the to-be-dispensed container; the mixing plate pats or compresses the to-be-dispensed container under driving of the linear motion assembly, thereby mixing the liquid in the to-be-dispensed container.

9. The liquid dispensing device according to claim 8, wherein the mounting plate is provided with a guiding hole; the linear motion assembly comprises a driving wheel, a driven wheel, a motor connected to the driving wheel and configured to drive the driving wheel to rotate, a timing belt sleeved on the driving wheel and the driven wheel, a connecting block connected to the timing belt, and a guiding shaft connected to the connecting block; an end of the guiding shaft away from the connecting block passes through the guiding hole to connect with the mixing plate.

10. The liquid dispensing device according to claim 9, wherein the linear motion assembly further comprises a linear bearing sleeved in the guiding hole and configured for guiding; the guiding shaft is slidably connected to the linear bearing.

11. The liquid dispensing device according to claim 9, wherein the guiding shaft comprises a first guiding shaft and a second guiding shaft; one end of the mixing plate is rotatably connected to the first guiding shaft, and the other end of the mixing plate is detachably connected to the second guiding shaft.

12. The liquid dispensing device according to claim 1, wherein the dispensing mechanism comprises dispensing switch valves correspondingly arranged at inlets of the dispensing bags and configured to control opening and closing of the inlets of the dispensing bags.

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