Cocristales de N-{cis-3-[metil(7H-pirrolo[2,3-d]pirimidin-4-yl)amino]ciclobutil}propane-1-sulfonamida

ES3040374B2Undetermined Publication Date: 2026-07-09MOEHS IBERICA SL (100 00)
View PDF 5 Cites 0 Cited by

Patent Information

Authority / Receiving Office
ES · ES
Patent Type
Patents
Current Assignee / Owner
MOEHS IBERICA SL (100 00)
Filing Date
2024-04-30
Publication Date
2026-07-09

AI Technical Summary

Technical Problem

Existing formulations of N-{cis-3-[methyl (7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide, such as abrocitinib, suffer from inadequate hygroscopicity and solubility, which hinders further pharmaceutical development and drug formulation.

Method used

The formation of cocrystals with hydroxylated derivatives like 4-hydroxybenzoic and 3,4-dihydroxybenzoic acids improves the hygroscopicity and solubility of N-{cis-3-[methyl (7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide, leading to more stable and easily handled solid dosage forms.

Benefits of technology

The cocrystals exhibit reduced hygroscopicity and enhanced solubility, particularly at pH below 4.5, facilitating improved handling and dosing regimens, and maintaining stability under forced stability conditions.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure 00000024_0000
    Figure 00000024_0000
  • Figure 00000025_0000
    Figure 00000025_0000
  • Figure 00000026_0000
    Figure 00000026_0000
Patent Text Reader

Abstract

N-{cis-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide cocrystals. The present invention relates to N-{cis-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide cocrystals, a process for obtaining said cocrystals, pharmaceutical compositions comprising said cocrystals, and their medical uses, in particular for the treatment or prevention of diseases known to be improved by inhibition of the Janus kinase 1 enzyme.
Need to check novelty before this filing date? Find Prior Art

Citation Information

Patent Citations

  • Crystal forms of sulfonamide compound and preparation method therefor

    EP4144737A1

  • Solid state form of abrocitinib and processes for its preparation

    IN202241046162A

  • Solid state forms of abrocitinib and processes for their preparation

    IN202341000258A

  • Manufacturing process and intermediates for a pyrrolo[2,3- d]pyrimidine compound and use thereof

    WO2020008391A1

  • Process for preparation of abrocitinib

    WO2020261041A1