Method for preparing a supplement from Wharton's jelly mesenchymal cell cultures and uses thereof

ES3072951T3Undetermined Publication Date: 2026-07-07
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Patent Information

Authority / Receiving Office
ES · ES
Patent Type
Patents
Filing Date
2017-09-25
Publication Date
2026-07-07

AI Technical Summary

Technical Problem

Existing methods for preparing epidermal and dermal equivalents face challenges such as high fragility, high cost, and the risk of zoonosis due to the use of animal-derived components, which can cause immune reactions and increase manufacturing costs.

Method used

A supplement is prepared from the supernatant of mesenchymal cell cultures obtained from Wharton's jelly, cultivated under specific conditions, which includes growth factors to promote cellular proliferation and reduce the risk of zoonosis while decreasing manufacturing costs.

Benefits of technology

The supplement enhances cellular activation, increases collagen synthesis, and stimulates the release of growth factors, effectively supporting the production of epidermal and dermal equivalents, reducing production costs and immune reaction risks.

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Abstract

This invention relates to a method for preparing a supplement from Wharton's jelly mesenchymal cell cultures comprising growth factors that promote the in vitro growth of cutaneous cell cultures, as well as to methods for preparing epidermal, dermal, or cutaneous equivalents using said supplement. It also relates to the use of said supplement to proliferate and activate autologous fibroblasts for subsequent intradermal application.
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