Fermentative production of N-acetylneuraminic acid

ES3073951T3Undetermined Publication Date: 2026-07-16CHR HANSEN HMO GMBH (100 00)
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Patent Information

Authority / Receiving Office
ES · ES
Patent Type
Patents
Current Assignee / Owner
CHR HANSEN HMO GMBH (100 00)
Filing Date
2018-10-17
Publication Date
2026-07-16

AI Technical Summary

Technical Problem

Existing methods for producing N-acetylneuraminic acid (Neu5Ac) are limited to small-scale production and require expensive substrates, with challenges in driving the reaction equilibrium and utilizing phosphoenolpyruvate for efficient biosynthesis.

Method used

A non-naturally-occurring microorganism engineered with a sialic acid synthesis pathway, disabled catabolic pathway, and capable of utilizing a single inexpensive carbon source without a phosphotransferase system, incorporating heterologous enzymes like glutamine-fructose-6-phosphate aminotransferase, glucosamine-6-phosphate N-acetyltransferase, and N-acetylneuraminic acid synthase for large-scale Neu5Ac production.

Benefits of technology

Enables efficient, large-scale production of Neu5Ac using an inexpensive carbon source, overcoming the limitations of small-scale and costly substrate requirements in existing methods.

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Abstract

Microorganisms not present in nature for the production of N-acetylneuraminic acid are described, as well as a method for the production of N-acetylneuraminic acid by fermentation of said microorganisms, and nutritional compositions containing N-acetylneuraminic acid produced by fermentation of the microorganisms not present in nature.
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