3D MICROFLUIDIC CHIP FOR THE STUDY OF STEOINTEGRATION / BIOINTEGRATION PROCESSES AND INFECTIONS IN BONE SCAFFOLDS AND / OR MINIATURE PROSTHETIC COMPONENTS

Abstract

Modular 3D system for the study of osseointegration / biointegration processes and infections in bone scaffolds and / or miniature prosthetic components. The invention relates to a 3D microfluidic chip (1) for the study of osseointegration / biointegration processes and infections in bone scaffolds and / or miniature prosthetic components, which includes 2 or more chambers (3), open on their upper face, connected in series or in parallel by means of flow channels (8) forming an assembly with a common inlet (4) for all chambers and a common outlet (9) or with an inlet and an outlet for each chamber. It also refers to a modular three-dimensional culture system (organ-on-a-chip) for the study of infections, osseointegration, biointegration and multi-organ models that includes 2 or more microfluidic chips (1) vertically or horizontally with a hermetic connection between the chambers (3) of the different chips (1), and its use.

Images