Vector calculus applied to a decision matrix for titrating anesthesia levels

ES3077434T3Undetermined Publication Date: 2026-09-01FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (100 00)
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Patent Information

Application Number
ES2020812425T
Authority / Receiving Office
ES · ES
Patent Type
Patents
Current Assignee / Owner
Filing Date
2020-10-28
Publication Date
2026-09-01
Estimated Expiration
2040-10-28

AI Technical Summary

Technical Problem

Current methods for modulating anesthesia levels during induction, maintenance, and awakening lack a standardized approach to adjust hypnotic and analgesic concentrations, relying on clinical experience and unstructured decision-making, which complicates achieving balanced anesthesia and managing patient reactions to surgical stress.

Method used

A vectorial calculation method that combines bispectral index (BIS) and mean arterial pressure (MAP) into a matrix to quantify deviations from an optimal anesthesia zone, allowing for quantitative adjustments to hypnotic and analgesic concentrations using an algorithm to standardize anesthesia management.

Benefits of technology

The method enables uniform, experience-independent management of anesthesia by integrating hypnotic and analgesic components, optimizing anesthesia levels and reducing variability in patient responses to surgical stress, thereby enhancing anesthesia control and safety.

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Abstract

A method for controlling hypnotic and analgesic concentrations of an anesthetic composition comprising the steps of: - providing a memory unit configured to receive and record data; - providing at least one data processing unit 101, in signal communication with the memory unit and configured to process and record data in the memory unit; - providing the bispectral index (PBIS) and mean arterial pressure (MAP) of a patient treated with a first anesthetic composition comprising an initial hypnotic concentration and an initial analgesic concentration, and storing the patient's PBIS and PMAP data in said memory unit; the method is characterized in that it comprises the steps of: - providing a two-dimensional array defined, on the abscissa, by a MAP dimension relating to the variation of the mean arterial pressure, and on the ordinate, by a BIS dimension relating to the variation of the bispectral index;- define in the matrix an optimal anesthesia zone (OAZ) located between MAP values ​​of 65 and 110 mmHg and BIS values ​​of 40 and 60; - locate the PBIS and PMAP data values ​​in the matrix to define a patient position (B) in the matrix with respect to the optimal anesthesia zone (OAZ); - provide an algorithm resident in said processing unit, configured to quantify the deviation of the patient position (B) with respect to the optimal anesthesia zone (OAZ) and transform the deviation into a quantitative variation of the initial hypnotic concentration and / or the initial analgesic concentration of the first anesthetic composition to define a target hypnotic concentration and / or a target analgesic concentration of a second anesthetic composition;- Process the patient's PBIS and PMAP data using said algorithm to obtain the target hypnotic concentration and / or the target anesthetic concentration of the second anesthetic composition.
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