Antibody drug conjugate

FI4183421T3Undetermined Publication Date: 2026-07-15CHIA TAI TIANQING PHARMA GRP CO LTD +1
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Patent Information

Authority / Receiving Office
FI · FI
Patent Type
Patents
Current Assignee / Owner
CHIA TAI TIANQING PHARMA GRP CO LTD
Filing Date
2021-08-13
Publication Date
2026-07-15

AI Technical Summary

Technical Problem

Current antibody-drug conjugates face challenges in developing highly potent and low-toxic ADCs that can target a wide range of cancer indications, particularly due to the inefficiency of camptothecin derivatives like SN-38 in converting to their active form and the poor solubility of these drugs.

Method used

Development of a deuterated antibody-drug conjugate with a deuterated modification in the linker or cytotoxic drug moiety, specifically designed to target HER2-positive cancers, using a conjugate structure of Ab-(L-U)n where Ab is an antibody moiety, L is a linker moiety, and U is a cytotoxic drug moiety, with modifications such as K30E and F53Y mutations in the VH and VL regions, respectively, to enhance binding affinity and pharmacokinetic properties.

Benefits of technology

The deuterated antibody-drug conjugate demonstrates improved binding affinity and reduced toxicity, leading to enhanced therapeutic efficacy and increased safety, effectively targeting HER2-positive cancers with improved pharmacokinetic properties.

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Abstract

Provided is an antibody drug conjugate, specifically comprising a therapeutic antibody moiety, an intermediate linker moiety and a cytotoxic drug moiety which are linked. The therapeutic antibody moiety is an antibody against an HER2 target. The cytotoxic drug moiety is a camptothecin topoisomerase I inhibitor. The cytotoxic drug moiety or the linker-cytotoxic drug moiety is modified by means of deuterium substitution. The antibody drug conjugate can be used for the prevention or treatment of cancers.
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