Antimicrobial Composition for use in Treating a Wound Infection
A novel antimicrobial composition using organosilanes, quarternary ammonium compounds, and surfactants effectively targets biofilms with low cytotoxicity, addressing antimicrobial resistance and biofilm challenges in wound infections.
Patent Information
- Authority / Receiving Office
- GB · GB
- Patent Type
- Patents
- Current Assignee / Owner
- HYBRISAN LTD
- Filing Date
- 2022-10-12
- Publication Date
- 2026-06-24
AI Technical Summary
The increasing antimicrobial resistance of bacteria, particularly Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus, necessitates the development of antimicrobial compositions effective against a wide range of microorganisms, including biofilms, while maintaining low cytotoxicity to prevent harm to human tissues.
A composition comprising water soluble organosilanes, quarternary ammonium compounds, amphoteric surfactants, and a chelating agent, specifically dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride, benzalkonium chloride, Cocomidopropyl betaine, and EDTA, is formulated to inhibit and disrupt biofilms with minimal cytotoxicity.
The composition effectively kills and inhibits microorganisms, including bacteria, fungi, and biofilms, with reduced cytotoxicity, demonstrated by significant log reductions in biofilm biomass and improved biofilm eradication compared to existing products.
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