Antimicrobial Composition for use in Treating a Wound Infection

A novel antimicrobial composition using organosilanes, quarternary ammonium compounds, and surfactants effectively targets biofilms with low cytotoxicity, addressing antimicrobial resistance and biofilm challenges in wound infections.

GB2627097BActive Publication Date: 2026-06-24HYBRISAN LTD
View PDF 7 Cites 0 Cited by

Patent Information

Application Number
GB2024006302
Authority / Receiving Office
GB · GB
Patent Type
Patents
Current Assignee / Owner
Priority Date
2021-10-13
Filing Date
2022-10-12
Publication Date
2026-06-24
Estimated Expiration
2042-10-12

AI Technical Summary

Technical Problem

The increasing antimicrobial resistance of bacteria, particularly Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus, necessitates the development of antimicrobial compositions effective against a wide range of microorganisms, including biofilms, while maintaining low cytotoxicity to prevent harm to human tissues.

Method used

A composition comprising water soluble organosilanes, quarternary ammonium compounds, amphoteric surfactants, and a chelating agent, specifically dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride, benzalkonium chloride, Cocomidopropyl betaine, and EDTA, is formulated to inhibit and disrupt biofilms with minimal cytotoxicity.

Benefits of technology

The composition effectively kills and inhibits microorganisms, including bacteria, fungi, and biofilms, with reduced cytotoxicity, demonstrated by significant log reductions in biofilm biomass and improved biofilm eradication compared to existing products.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure 00000001_0000
    Figure 00000001_0000
  • Figure 00000001_0001
    Figure 00000001_0001
  • Figure 00000002_0000
    Figure 00000002_0000
Patent Text Reader

Abstract

The present invention provides an antimicrobial composition comprising: (i) one or more water soluble organosilanes at a concentration of about 0.01% to about 0.4% w / v; (ii) one or more quarternary am
Need to check novelty before this filing date? Find Prior Art

Citation Information

Patent Citations

  • Production of stable aqueous hydrolyzable organosilane solutions

    EP0640122B1

  • Hard surface antimicrobial cleaner with residual antimicrobial effect

    US20030073600A1

  • Animal tissue colonization and treatment of infection

    US20170042916A1

  • Antimicrobial sanitizer compositions and their use

    US20170094974A1

  • Skin, Nail and Hair Topical Antimicrobial Methods Using Formulations Containing Organosilane Quaternaries

    US20170189318A1