Means and methods to target endogenous condensates
A system using IDR polypeptide segments and effector domains covalently modifies intracellular aggregates to alter their properties, addressing the challenge of modifying endogenous intracellular condensates associated with diseases.
Patent Information
- Authority / Receiving Office
- HK · HK
- Patent Type
- Applications
- Current Assignee / Owner
- MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN EV
- Filing Date
- 2026-04-28
- Publication Date
- 2026-07-10
AI Technical Summary
Existing technologies lack effective methods to modify the chemical or physical properties of endogenous intracellular aggregates formed by intracellular proteins containing intrinsic disorder regions (IDRs), which are associated with various diseases and disorders.
A system comprising an IDR polypeptide sequence segment and an effector polypeptide domain that covalently modifies target biomolecules within these aggregates to alter their properties.
The system effectively modifies the chemical or physical properties of intracellular condensates, potentially addressing underlying disease mechanisms.
Smart Images
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Abstract
Description
This invention relates to a system for modifying target biomolecules associated with endogenous intracellular aggregates formed by intracellular proteins containing intrinsic disorder regions (IDRs), or to a system for modifying the chemical or physical properties of endogenous intracellular aggregates. The system of this invention, as its smallest constituent, comprises: an IDR polypeptide sequence segment containing the intrinsic disorder region of the intracellular protein; and an effector polypeptide domain capable of covalently modifying the target biomolecule. Abstract MEANS AND METHODS TO TARGET ENDOGENOUS CONDENSATES The invention relates to a system for modifying a target biomolecule that is associated to an endogenous intracellular condensate formed by an intracellular protein an Intrinsically Disordered Region (IDR), or to a system for modifying a chemical or physical property of an endogenous intracellular condensate. Intrinsically Disordered Region of the intracellular protein, and an effector polypeptide domain capable of covalently modifying said target biomolecule. Abstract
Claims
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