Compound and use thereof as Anti-cancer drug
Compounds with formula (I) are developed as SHP2 inhibitors to address the lack of effective cancer treatment options by targeting the SHP2 protein, offering a targeted therapy to suppress cancer progression and metastasis.
Patent Information
- Authority / Receiving Office
- HK · HK
- Patent Type
- Applications
- Current Assignee / Owner
- TYLIGAND BIOSCIENCE (SHANGHAI) LIMITED
- Filing Date
- 2026-05-13
- Publication Date
- 2026-07-10
AI Technical Summary
Current cancer treatments lack effective inhibitors targeting the SHP2 protein, which plays a crucial role in cancer progression and metastasis, necessitating the development of novel compounds that can selectively inhibit this protein to combat cancer effectively.
Development of compounds with the structure of formula (I) that function as SHP2 inhibitors, integrated into pharmaceutical compositions for targeted cancer therapy.
The compounds effectively inhibit SHP2 protein activity, providing a targeted approach to cancer treatment by suppressing cancer progression and metastasis.
Abstract
Description
(19) State Intellectual Property Office (12) Invention Patent Application (10) Application Publication Number (43) Application Publication Date (21) Application Number 202480045835.0 (22) Application Date 2024.07.05 (66) Domestic Priority Data 202310836777.0 2023.07.07 CN (85) PCT International Application Entering National Phase Date 2026.01.06 (86) PCT International Application Application Data PCT / CN2024 / 103967 2024.07.05 (87) PCT International Application Publication Data WO2025 / 011480 ZH 2025.01.16 (71) Applicant Taili Biotechnology (Shanghai) Co., Ltd. Address 3728 Jinke Road, Pudong New Area, Shanghai 201203, China Building B, 5th Floor, No. 1 (72) Inventors: Zhong Boyu, Wang Qian, Zhang Yantao, Dong Chunlan, Pang Wei, Qin Quan, Wang Zhiqiang, Lu Wanglong, Wang Jifa (74) Patent Agency: Beijing Zhongzi Law Firm, 11247 Patent Agents: Chen Runjie, Huang Gesheng (51) Int.Cl. C07D 291 / 08 (2006.01) A61K 31 / 16 (2006.01) A61K 31 / 33 (2006.01) A61P 35 / 00 (2006.01) (54) Invention Name: Compound and its Use as an Anticancer Drug (57) Abstract: This invention provides compounds having the structure of formula (I) that can be used as SHP2 inhibitors, pharmaceutical compositions containing such compounds, methods for preparing such compounds, and the use of these compounds in the treatment of cancer. CN 121568930 A 2026.02.24 CN 1 21 56 89 30 A