Peptide inhibitors of interleukin-23 receptor

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IL-23R peptide inhibitors with gastrointestinal stability address the inadequacies of existing treatments for inflammatory diseases by ensuring effective treatment of Crohn's disease, ulcerative colitis, and psoriasis.

HK40134790APending Publication Date: 2026-07-10ZEALAND PHARMA AS

Patent Information

Authority / Receiving Office: HK · HK
Patent Type: Applications
Current Assignee / Owner: ZEALAND PHARMA AS
Filing Date: 2026-05-14
Publication Date: 2026-07-10

AI Technical Summary

Technical Problem

Existing treatments for inflammatory diseases such as Crohn's disease, ulcerative colitis, and psoriasis are inadequate in providing effective and stable IL-23R peptide inhibitors that maintain efficacy in the gastrointestinal tract.

Method used

Development of IL-23R peptide inhibitors with good physical and chemical stability in the gastrointestinal tract to treat or prevent inflammatory diseases.

Benefits of technology

The developed IL-23R peptide inhibitors provide effective treatment or prevention of inflammatory diseases by maintaining stability in the gastrointestinal tract, enhancing therapeutic efficacy.

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Abstract

The present invention relates to compounds that are peptide inhibitors of interleukin-23 receptor (IL-23R) and to their use in the treatment or prevention of a variety of diseases, conditions or disorders, including inflammatory diseases, such as inflammatory bowel disease such as Crohn's disease or ulcerative colitis, psoriatic arthritis and psoriasis. The compounds have good physical and chemical stability in the gastrointestinal tract.

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Description

Request to Record Designated Patent Application No. EP24731274.7 (Publication No. EP4720087) in Hong Kong. Our Ref.: P4776HK00 54) Title: Interleukin-23 Receptor Peptide Inhibitors 57) Abstract: This invention relates to a class of interleukin-23 receptor (IL-23R) peptide inhibitors and their use in the treatment or prevention of a variety of diseases, conditions, or disorders, including inflammatory diseases such as inflammatory bowel diseases (e.g., Crohn's disease or ulcerative colitis), psoriatic arthritis, and psoriasis. These compounds exhibit good physical and chemical stability in the gastrointestinal tract. Abstract

Claims

CLAIMS 1. A compound of the formula: Z-R2wherein R2is NHR3or C(=O)R3, wherein R3is hydrogen or C1-6 alkyl optionally substituted with a pyridyl ring, or is absent; and Z is an amino acid sequence of formula I: X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13 (I) wherein X2 is selected from the group consisting of Lys, D-lys, iso-Lys, D-iso-Lys, beta-Lys, D-beta-Lys, homo-Lys, D-homo-Lys, beta-homo- Lys, N-Me-Lys, N-Me-homo-Lys, (N3)-Lys, D-(N3)-Lys, (N3)-beta-Lys, (N3)-D-beta-Lys, (N3)-homo-Lys, (N3)-D-homo-Lys, (N3)-beta-homo-Lys, Dpr, D-Dpr, iso-Dpr, D-iso-Dpr, beta-Dpr, D-beta-Dpr, homo-Dpr, D-homo-Dpr, beta- homo-Dpr, N-Me-Dpr, N-Me-homo-Dpr, (N3)-Dpr, D-(N3)-Dpr, (N3)-beta-Dpr, (N3)-D-beta- Dpr, (N3)-homo-Dpr, (N3)-D-homo-Dpr, (N3)-beta-homo-Dpr, Dab, D-Dab, iso-Dab, D-iso-Dab, beta-Dab, D-beta-Dab, homo-Dab, D-homo-Dab, beta- homo-Dab, N-Me-Dab, N-Me-homo-Dab, (N3)-Dab, D-(N3)-Dab, (N3)-beta-Dab, (N3)-D- beta-Dab, (N3)-homo-Dab, (N3)-D-homo-Dab, (N3)-beta-homo-Dab, Orn, D-Orn, iso-Orn, D-iso-Orn, beta-Orn, D-beta-Orn, homo-Orn, D-homo-Orn, beta- homo-Orn, N-Me-Orn, N-Me-homo-Orn, (N3)-Orn, D-(N3)-Orn, (N3)-beta-Orn, (N3)-D-beta- Orn, (N3)-homo-Orn, (N3)-D-homo-Orn, (N3)-beta-homo-Orn, Lys(Gly), Asp, D-Asp, iso-Asp, D-iso-Asp, beta-Asp, D-beta-Asp, homo-Asp, D-homo-Asp, beta- homo-Asp, N-Me-Asp, N-Me-homo-Asp, (N3)-Asp, D-(N3)-Asp, (N3)-beta-Asp, (N3)-D-beta- Asp, (N3)-homo-Asp, (N3)-D-homo-Asp, (N3)-beta-homo-Asp,Glu, D-Glu, iso-Glu, D-iso-Glu, beta-Glu, D-beta-Glu, homo-Glu, D-homo-Glu, beta-homo- Glu, N-Me-Glu, N-Me-homo-Glu, (N3)-Glu, D-(N3)-Glu, (N3)-beta-Glu, (N3)-D-beta-Glu, (N3)-homo-Glu, (N3)-D-homo-Glu, (N3)-beta-homo-Glu, 2-amino-6-carboxyhexanoyl and 3-aminopropanoyl; X3 is selected from any amino acid, -hydroxy-C2-6 alkanoic acid or is absent; X4 is selected from the group consisting of Val, D-Val, beta-Val, D-beta-Val, homo-Val, D- homo-Val, beta-homo-Val, N-Me-Val, N-Me-homo-Val, 2-Me-Val, Ala, D-Ala, beta-Ala, D-beta-Ala, homo-Ala, D-homo-Ala, beta-homo-Ala, N-Me-Ala, N- Me-homo-Ala, Gly, beta-Gly, homo-Gly, beta-homo-Gly, N-Me-Gly, N-Me-homo-Gly, Leu, D-Leu, beta-Leu, D-beta-Leu, homo-Leu, D-homo-Leu, beta-homo-Leu, N-Me-Leu, N-Me-homo-Leu, 2-Me-Leu, Ile, D-Ile, beta-Ile, D-beta-Ile, homo-Ile, D-homo-Ile, beta-homo-Ile, N-Me-Ile, N-Me-homo- Ile or is absent; X5 is selected from the group consisting of an optionally substituted tryptophan residue, an optionally substituted azatryptophan residue, and an optionally substituted beta- homotryptophan residue; X6 is selected from the group consisting of an optionally substituted Gln residue, an optionally substituted Lys residue, an optionally substituted Arg residue, an optionally substituted Dab residue, an optionally substituted Orn residue, an optionally substituted Phe residue, Ala, D-Ala, beta-Ala, D-beta-Ala, homo-Ala, D-homo-Ala, beta-homo-Ala, N- Me-Ala, N-Me-homo-Ala, Cit, D-Cit, beta-Cit, D-beta-Cit, homo-Cit, D-homo-Cit, beta- homo-Cit, N-Me-Cit, N-Me-homo-Cit, Glu, D-Glu, iso-Glu, D-iso-Glu, beta-Glu, D-beta-Glu, homo-Glu, D-homo-Glu, beta-homo-Glu, N-Me-Glu, N-Me-homo-Glu, Tyr, D-Tyr, beta-Tyr, D-beta-Tyr, homo-Tyr, D-homo-Tyr, beta-homo-Tyr, N-Me-Tyr, N-Me-homo-Tyr, Val, D- Val, beta-Val, D-beta-Val, homo-Val, D-homo-Val, beta-homo-Val, N-Me-Val, N-Me-homo- Val or His, D-His, beta-His, D-beta-His, homo-His, D-homo-His, beta-homo-His, N-Me-His and N-Me-homo-His; X7 is selected from the group consisting of Asp, D-Asp, iso-Asp, D-iso-Asp, beta-Asp, D- beta-Asp, homo-Asp, D-homo-Asp, beta-homo-Asp, N-Me-Asp, N-Me-homo-Asp,Glu, D-Glu, iso-Glu, D-iso-Glu, beta-Glu, D-beta-Glu, homo-Glu, D-homo-Glu, beta-homo- Glu, N-Me-Glu, N-Me-homo-Glu, Dab, D-Dab, iso-Dab, D-iso-Dab, beta-Dab, D-beta-Dab, homo-Dab, D-homo-Dab, beta- homo-Dab, N-Me-Dab, N-Me-homo-Dab, Orn, D-Orn, iso-Orn, D-iso-Orn, beta-Orn, D-beta-Orn, homo-Orn, D-homo-Orn, beta- homo-Orn, N-Me-Orn, N-Me-homo-Orn, Lys, D-Lys, iso-Lys, beta-Lys, D-iso-Lys, D-beta-Lys, homo-Lys, D-homo-Lys, beta-homo- Lys, N-Me-Lys, N-Me-homo-Lys, Pra, D-Pra, beta-Pra, D-beta-Pra, homo-Pra, D-homo-Pra, beta-homo-Pra, N-Me-Pra, N- Me-homo-Pra, Hpg, D-Hpg, beta-Hpg, D-beta-Hpg, homo-Hpg, D-homo-Hpg, beta-homo-Hpg, N-Me-Hpg and N-Me-homo-Hpg; X8 is selected from the group consisting of an optionally substituted tryptophan residue, an optionally substituted azatryptophan residue, an optionally substituted beta- homotryptophan residue, an optionally substituted tyrosine residue, an optionally substituted phenylalanine residue, an optionally substituted homophenylalanine residue, and an alanine residue substituted by a carbocyclic group or an aromatic or heteroaromatic group selected from the group consisting of phenyl, pyridyl, naphthyl and quinolinyl, each optionally substituted; X9 is selected from the group consisting of an optionally substituted tryptophan residue, an optionally substituted azatryptophan residue, an optionally substituted alanine residue, an optionally substituted phenylalanine and an optionally substituted tyrosine residue; X10 is selected from the group consisting of, Val, D-Val, beta-Val, D-beta-Val, homo-Val, D-homo-Val, beta-homo-Val, N-Me-Val, N- Me-homo-Val, 2-Me-Val, Gly, beta-Gly, homo-Gly, beta-homo-Gly, N-Me-Gly, N-Me-homo-Gly, Dab, D-Dab, iso-Dab, D-iso-Dab, beta-Dab, D-beta-Dab, homo-Dab, D-homo-Dab, beta- homo-Dab, N-Me-Dab, N-Me-homo-Dab,Lys, D-lys, iso-Lys, D-iso-Lys, beta-Lys, D-beta-Lys, homo-Lys, D-homo-Lys, beta-homo- Lys, N-Me-Lys, N-Me-homo-Lys, Aib, D-Aib, beta-Aib, D-beta-Aib, homo-Aib, D-homo-Aib, beta-homo-Aib, N-Me-Aib, N- Me-homo-Aib, Ala, D-Ala, beta-Ala, D-beta-Ala, homo-Ala, D-homo-Ala, beta-homo-Ala, N-Me-Ala, N- Me-homo-Ala, Leu, D-Leu, beta-Leu, D-beta-Leu, homo-Leu, D-homo-Leu, beta-homo-Leu, N-Me-Leu, N-Me-homo-Leu, 2-Me-Leu, Ile, D-Ile, beta-Ile, D-beta-Ile, homo-Ile, D-homo-Ile, beta-homo-Ile, N-Me-Ile, N-Me-homo- Ile, and a carbocyclic or heterocyclic ring having an amino substituent and a carbonyl substituent; X11 is selected from the group consisting of Dpr, D-Dpr, iso-Dpr, D-iso-Dpr, beta-Dpr, D-beta-Dpr, homo-Dpr, D-homo-Dpr, beta- homo-Dpr, N-Me-Dpr, N-Me-homo-Dpr, Dab, D-Dab, iso-Dab, D-iso-Dab, beta-Dab, D-beta-Dab, homo-Dab, D-homo-Dab, beta- homo-Dab, N-Me-Dab, N-Me-homo-Dab, Orn, D-Orn, iso-Orn, D-iso-Orn, beta-Orn, D-beta-Orn, homo-Orn, D-homo-Orn, beta- homo-Orn, N-Me-Orn, N-Me-homo-Orn, Lys, D-lys, iso-Lys, D-iso-Lys, beta-Lys, D-beta-Lys, homo-Lys, D-homo-Lys, beta-homo- Lys, N-Me-Lys, N-Me-homo-Lys, Lys(Me), Lys(Gly), Asp, D-Asp, iso-Asp, D-iso-Asp, beta-Asp, D-beta-Asp, homo-Asp, D-homo-Asp, beta- homo-Asp, N-Me-Asp, N-Me-homo-Asp, Glu, D-Glu, iso-Glu, D-iso-Glu, beta-Glu, D-beta-Glu, homo-Glu, D-homo-Glu, beta-homo- Glu, N-Me-Glu, N-Me-homo-Glu, and 2-amino-6-carboxyhexanoyl;X12 is selected from the group consisting of an optionally substituted Phe residue, an optionally substituted Tyr residue, an optionally substituted His residue, an alanine residue substituted by a carbocyclic group or an aromatic or heteroaromatic group selected from the group consisting of phenyl, pyridyl, naphthyl and quinolinyl, each optionally substituted, Dab, D-Dab, iso-Dab, D-iso-Dab, beta-Dab, D-beta-Dab, homo-Dab, D-homo- Dab, beta-homo-Dab, N-Me-Dab, N-Me-homo-Dab, Gly, , beta-Gly, homo-Gly, , beta- homo-Gly, N-Me-Gly, N-Me-homo-Gly, Pro, 5-aminopentanoyl,4-aminopiperidin-4- carbonyl, (R,S)-Imidazolidin-2-carbonyl, 3-aminopropanoyl, Gly-CF3, D-Gly-CF3, Nle, Gln, D-Gln, iso-Gln, D-iso-Gln, beta-Gln, D-beta-Gln, homo-Gln, D-homo-Gln, beta-homo-Gln, N-Me-Gln, N-Me-homo-Gln, THP, Ser, D-Ser, beta-Ser, D-beta-Ser, homo-Ser, D-homo- Ser, beta-homo-Ser, N-Me-Ser, N-Me-homo-Ser, Ser(OMe), 3-aminotetrahydrofuran-3- carbonyl, Arg, D-Arg, beta-Arg, D-beta-Arg, homo-Arg, D-homo-Arg, beta-homo-Arg, N- Me-Arg, N-Me-homo-Arg, , Thr, D-Thr, beta-Thr, D-beta-Thr, homo-Thr, D-homo-Thr, beta-homo-Thr, N-Me-Thr, N-Me-homo-Thr Glu, D-Glu, iso-Glu, D-iso-Glu, beta-Glu, D- beta-Glu, homo-Glu, D-homo-Glu, beta-homo-Glu, N-Me-Glu, N-Me-homo-Glu, Asn, D- Asn, beta-Asn, D-beta-Asn, homo-Asn, D-homo-Asn, beta-homo-Asn, N-Me-Asn, N-Me- homo-Asn, 4-aminobutanoyl, 2-(trimethyl-2-aminoethoxy)ethoxy]propyl and Lys wherein the side chain -NH2of the Lys is substituted with -C(=O)(CH2)nRKwherein n is 0-2 and RKis imidazolyl, pyrimidyl, or pyridyl optionally substituted with F, or X12 is absent; and X13 is selected from the group consisting of an optionally substituted His residue, an optionally substituted Phe residue, an alanine residue substituted by a carbocyclic group or an aromatic or heteroaromatic group selected from the group consisting of phenyl, pyridyl, naphthyl and quinolinyl, each optionally substituted, Asn, D-Asn, beta-Asn, D- beta-Asn, homo-Asn, D-homo-Asn, beta-homo-Asn, N-Me-Asn, N-Me-homo-Asn, Gly, , beta-Gly, , homo-Gly, , beta-homo-Gly, N-Me-Gly, N-Me-homo-Gly, and Dab, Orn or Lys wherein the side chain -NH2is substituted with -C(=O)(CH2)nRK wherein n is 0-2 and RKis imidazolyl, pyrimidyl, or pyridyl optionally substituted with F, or is absent; wherein (i) X2 and X11 are amino acid residues who together form a lactam bridge; (ii) X2 and X7 are amino acid residues who together form a lactam bridge or a bridge containing a triazole ring; and(iii) optionally, when X13 is present, X10 and X13 are amino acid residues who together form a lactam bridge; or a pharmaceutically acceptable salt or solvate thereof.

2. The compound according to claim 1, wherein X2 is selected from the group consisting of Dab, D-Dab, iso-Dab, Lys, iso-Lys, D-beta-Lys, N-Me-Lys, homo-Lys, D-Lys, D-homo-Lys, beta-Lys, beta-homo-Lys, Lys(Gly), (N3)-Lys, D-(N3)-Lys, D-iso-Glu, iso-Glu, Glu, Orn, D-Orn, Dpr, and Lys(Gly).

3. The compound according to any one of claims 1 or 2, wherein X3 is selected from the group consisting of Thr, Ile, 3-aminopropanoyl, 4-aminobutanoyl, beta-homo-Ile, beta- homo-Thr, beta-homo-Trp, Gly, N-Me-3-aminopropanoyl, Ser, Trp, Phe, N-Me-Ser, N-Me- Ala, 3-hydroxypropanoic acid or is absent.

4. The compound according to any of on claims 1 to 3, wherein X4 is absent or Val.

5. The compound according to any of claims 1 to 4, wherein X5 is selected from the group consisting of Trp, 1-Me-Trp, 7-Aza-Trp, 7-Me-Trp and beta-homo-Trp.

6. The compound according to any one of claims 1 to 5, wherein X6 is selected from the group consisting of Dab(Ac), Dab(Ac-N-Me), Gln, Gln(2Me), K(NMePEG3) and Gln(Me).

7. The compound according to any one of claims 1 to 6, wherein X7 is selected from the group consisting of Asp, D-Glu, Glu, Pra, Hpg and homo-Glu.

8. The compound according to any one of claims 1 to 7, wherein X8 is selected from the group consisting of Y(2-aminoethoxy), Y(2-aminoethoxy)(N(Me)2), Y(nPentylamine) (N+(Me)3), Y(2-trimethyl-PEG2), homo-Phe, 7-AzaTrp, beta-homo-Trp, 7-F-Trp, F(4- morpholine), 3-quinolinylalanine, Y(Me), Y(nPr), Y(Bn), Trp, D-Phe, 2-Me-Phe, F(4-Me), F(4-Bu), 3-(2-Pyridyl)-Ala, 3-(3-Pyridyl)-Ala, 3-(4-Pyridyl)-Ala, Cyclopropyl-Ala, F(4-THP), Y(CH3-2-F), F(4-F), F(4-piperazine), F(4-imidazole), F(4-piperidine), Y(CH3-3-F), 5- AzaTrp, Y(Ac-2-aminoethoxy), 6-AzaTrp and F(4-CONH2).

9. The compound accoridng to any one of claims 1 to 8, wherein X9 is selected from the group consisting of 2NaI and cyclopropyl-Ala. 10 The compound according to any one of claims 1 to 9, wherein X10 is selected from the group consisting of Dab, 2-Me-Leu, 2-Me-Val, Aib, D-Ala, Gly and Lys.

11. The compound according to any one of claims 1 to 10, wherein X11 is selected from the group consisting of Dab, 2-amino-6-carboxyhexanoyl, beta-homo-Glu, Glu, homo-Glu, iso-Dab, Lys, Orn and Lys(Me).

12. The compound according to any one of claims 1 to 11, wherein X12 is selected from the group consisting of Dab, His, D-His, His(1-Me), 3-(2-Pyridyl)-Ala, 3-(3-Pyridyl)- Ala, 3-(4-Pyridyl)-Ala, 3-(3-Quinolinyl)-Ala, Gly, Pro, Ser(OCH3), 5-aminopentanoyl, 4- aminopiperidin-4-carbonyl, (R,S)-Imidazolidin-2-carbonyl, and Lys wherein the side chain - NH2 of the Lys is substituted with -C(=O)(CH2)nRKwherein n is 0-2 and RKis imidazolyl, pyrimidyl, or pyridyl optionally substituted with F, or X12 is absent.

13. The compound according to any one of claims 1 to 12, wherein X13 is selected from the group consisting of 3-(3-Pyridyl)-Ala, D-3-(3-Pyridyl)-Ala, and 3-(3,5-Pyrimidyl)- Ala, or is absent.

14. The compound according to any one of claims 1 to 13, wherein: Z-R2wherein R2is NHR3wherein R3is hydrogen or C1-6alkyl optionally substituted with a pyridyl ring, or is absent; and Z is an amino acid sequence of formula Ia: X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13 (Ia) wherein X2 is selected from the group consisting of Lys, D-Lys, iso-Lys, beta-Lys, D-beta-Lys, homo-Lys, D-homo-Lys, , beta-homo-Lys, N-Me-Lys, Dab, D-Dab, Glu, iso-Glu, Orn, D- Orn, Lys(Gly), (N3)-Lys and D-(N3)-Lys; X3 is selected from the group consisting of Thr, Trp, Ile, 3-aminopropanoyl, 4- aminobutanoyl, beta-homo-Ile, beta-homo-Thr, Gly, and N-Me-3-aminopropanoyl, 3- hydroxypropanoic acid or is absent; X4 is Val or is absent; X5 is Trp or 1-Me-Trp;X6 is Gln, Gln(Me), Dab(Ac-N-Me), Dab(Ac) or Gln(2Me); X7 is selected from the group consisting of Glu, homo-Glu, Asp, Pra, and Hpg; X8 is selected from the group consisting of Y(2-aminoethoxy), Y(Me), Y(Bn), Y(2- aminoethoxy)(N(Me)2), Y(nPentylamine)(N+(Me)3), Y(2-trimethyl-PEG2), F(4-Me), F(4- Bu), Cyclopropyl-Ala, F(4-morpholine), F(4-THP), Y(CH3-2-F), F(4-F), F(4-piperazine), F(4-imidazole), Y(CH3-3-F), F(4piperidine), 5-AzaTrp, Y(Ac-2-aminoethoxy), 7-AzaTrp, 6- AzaTrp, F(4-CONH2); X9 is 2-Nal; X10 is selected from the group consisting of 2-Me-Leu, 2-Me-Val, D-Ala, Dab, Gly, and Aib; X11 is selected from the group consisting of Glu, homo-Glu, Lys, Lys(Me), Orn, and 2- amino-6-carboxyhexanoyl; X12 is selected from the group consisting of Dab, His, S(OCH3), D-His, His(1-Me), 3-(3- Quinolinyl)-Ala, and 4-aminopiperidin-4-carbonyl; and X13 is 3-(3-Pyridyl)-Ala, 3-(3,5-Pyrimidyl)-Ala, or is absent; wherein (i) X2 and X11 are amino acid residues who together form a lactam bridge; (ii) X2 and X7 are amino acid residues who together form a lactam bridge or a bridge containing a triazole ring; and (iii) optionally, when X13 is present, X10 and X13 are amino acid residues who together form a lactam bridge; or a pharmaceutically acceptable salt or solvate thereof.

15. The compound according to any one of claims 1 to 14, wherein the lactam bridge between X2 and X11 uses the side chain of the amino acid residue at X2, and the bridge between X2 and X7 uses the N-terminus of the amino acid residue at X2.

16. The compound according to any one of the preceding claims, wherein X2 is Lys; optionally wherein X3 is selected from the group consisting of Thr, Ile, and 3- aminopropanoyl, or is absent. optionally wherein X4 is absent.

17. The compound according to any one of the preceding claims, wherein X5 is Trp; optionally wherein X7 is Glu; optionally wherein X8 is Y(2-aminoethoxy), Y(Me), or F(4-Me); optionally wherein X8 is Y(2-aminoethoxy).

18. The compound according to any one of the preceding claims, wherein X9 is 2-Nal; optionally wherein X10 is 2-Me-Leu or 2-Me-Val; optionally wherein X10 is 2-Me-Leu; optionally wherein X11 is Glu.

19. The compound according to any one of the preceding claims, wherein X12 is Dab; optionally wherein X13 is 3-(3-Pyridyl)-Ala or is absent; optionally wherein X13 is 3-(3- Pyridyl)-Ala.

20. The compound according to any one of the preceding claims, wherein R2is NHR3wherein R3is hydrogen or C1-6alkyl; optionally wherein R2is NH2or NHMe.

21. The compound according to any one of the preceding claims, wherein: X2 is Lys; X5 is Trp; X9 is 2-Nal; and X10 is 2-Me-Leu; or X2 is Lys; X5 is Trp; X9 is 2-Nal; X10 is 2-Me-Leu; and R2is NH2or NHMe; orX2 is Lys; X5 is Trp; X9 is 2-Nal; X10 is 2-Me-Leu; X13 is 3-(3-Pyridyl)-Ala or is absent, and R2is NH2 or NHMe; or X2 is Lys; X5 is Trp; X7 is Glu; X9 is 2-Nal; X10 is 2-Me-Leu; X13 is 3-(3-Pyridyl)-Ala or is absent, and R2is NH2 or NHMe.

22. The compound according to claim 1 wherein Z is an amino acid sequence selected from the group consisting of: SEQ ID NO: Sequence [{d}K] ^ SEQ ID NO: 1 (1c)(6c) TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 2 K(1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3- (3-Pyridyl)-Ala] SEQ ID NO: 3 [{d}K](1c)(6c)^TVWQD(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 4 [hLys](1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 5 [{d}hLys](1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 6 [{d}Orn](1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu][hGlu](1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 7 [{d}Dab](1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu][2- Amino-6-carboxyhexanoyl](1c)[Dab][3-(3-Pyridyl)-Ala] [{d}Orn](1c ^ SEQ ID NO: 8 )(6c) TVWQD(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu][hGlu](1c)[Dab][3-(3-Pyridyl)-Ala] [{d}Dab]( ^ SEQ ID NO: 9 1c)(6c) TVWQD(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu][2- Amino-6-carboxyhexanoyl](1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 10 [{d}Orn](1c)(6c)^TVWQD(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 11 [{d}Dab](1c)(6c)^TVWQD(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 12 [bLys](1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 13 [{d}bLys](1c)(6c)^TWQD(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]SEQ ID NO: Sequence SEQ ID NO: 14 [{d}bLys](1c)(6c)^TWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 15 [{d}Dab](1c)(6c)^TWQD(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu][2-Amino- 6-carboxyhexanoyl](1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 16 K(1c)(6c)^IVWQE(6c)[F(4-Me)][2-Nal][2-Me-Val]E(1c)[Dab][3-(3-Pyridyl)- Ala]SEQ ID NO: 17K(1c)(6c)^IVWQE(6c)[F(4-Me)][2-Nal][Aib]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 18 K(1c)(6c)^IVWQE(6c)[F(4-Me)][2-Nal][2-Me-Val]E(1c)[Dab][{d}3-(3- Pyridyl)-Ala] SEQ ID NO: 19 K(1c)(6c)^IVWQE(6c)[F(4-Me)][2-Nal][2-Me-Val]E(1c)G[{d}3-(3-Pyridyl)- Ala] SEQ ID NO: 20 K(1c)(6c)^IVWQE(6c)[Cyclopropyl-Ala][2-Nal][2-Me-Val]E(1c)G[{d}3-(3- Pyridyl)-Ala] SEQ ID NO: 21 K(1c)(6c)^IVWQE(6c)[2-Me-Phe][2-Nal][2-Me-Val]E(1c)G[{d}3-(3-Pyridyl)- Ala]SEQ ID NO: 22K(1c)(6c)^IVWQE(6c)[{d}F][2-Nal][2-Me-Val]E(1c)G[{d}3-(3-Pyridyl)-Ala] K(1c)(6 ^ SEQ ID NO: 23 c) IVWQE(6c)[F(4-Me)][Cyclopropyl-Ala][2-Me-Val]E(1c)G[{d}3-(3- Pyridyl)-Ala]SEQ ID NO: 24K(1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu][iso-Dab](1c)^SEQ ID NO: 25K(1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu][iso-Dab](1c)^SEQ ID NO: 26K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Val]E(1c)SEQ ID NO: 27K(1c)(6c)^IVWQ[{d}E](6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Val]E(1c)SEQ ID NO: 28K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Val]E(1c)SEQ ID NO: 29K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Val]E(1c)SEQ ID NO: 30K(1c)(6c)^SVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)SEQ ID NO: 31K(1c)(6c)^SVWQE(6c)[Y(2-aminoethoxy)][2-Nal]GE(1c)SEQ ID NO: SequenceSEQ ID NO: 32K(1c)(6c)^IVWQE(6c)[Y(nPr)][2-Nal][2-Me-Leu]E(1c) SEQ ID NO: 33 K(1c)(6c)^IVWQE(6c)[F(4-Bu)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3-Pyridyl)- Ala] SEQ ID NO: 34 K(1c)(6c)^IVWQE(6c)[Y(Bn)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3-Pyridyl)- Ala] SEQ ID NO: 35 K(1c)(6c)^IVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3-Pyridyl)- Ala] SEQ ID NO: 36 K(1c)(6c)^TWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3- Pyridyl)-Ala] SEQ ID NO: 37 [Dab](1c)(6c)^TWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 38 K(1c)(6c)^TWQ[hGlu](6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] ^ SEQ ID NO: 39 E(1c)(6c) TWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]K(1c)[Dab][3-(3- Pyridyl)-Ala] E(1c)(6c)^ SEQ ID NO: 40 TWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu][Orn](1c)[Dab][3-(3-Pyridyl)-Ala] [(N3)-K](1c)(6g ^ SEQ ID NO: 41 ) TWQ[Pra](6g)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] [{d}(N3)-K](1 ^ SEQ ID NO: 42 c)(6g) TWQ[Hpg](6g)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] K(1c)(6c)^ SEQ ID NO: 43 WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3- Pyridyl)-Ala] SEQ ID NO: 44 K(1c)(6c)^GWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3- Pyridyl)-Ala] SEQ ID NO: 45 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 46 [K(G)](1c)(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3- (3-Pyridyl)-Ala]SEQ ID NO: 47K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(piconilate)]SEQ ID NO: 48K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(2-pyridylacetyl)] SEQ ID NO: 49 K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(2- pyridylpropionyl)]SEQ ID NO: SequenceSEQ ID NO: 50K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(nicotinate)]SEQ ID NO: 51K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(3-pyridylacetyl)] SEQ ID NO: 52 K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(3- pyridylpropionyl)]SEQ ID NO: 53K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(isonicotinyl)]SEQ ID NO: 54K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(4-pyridylacetyl)] SEQ ID NO: 55 K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(4- pyridylpropionyl)]SEQ ID NO: 56K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(3,5-pyrimidine)] SEQ ID NO: 57 K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(4-pyridyl-3- fluoroacetyl)]SEQ ID NO: 58K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(Imidazoleacetyl)] SEQ ID NO: 59 K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me- Leu]E(1c)[K(Imidazolepropanoyl)] SEQ ID NO: 60 K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3- (3-Pyridyl)-Ala] SEQ ID NO: 61 K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu][beta- hGlu](1c)[3-(3-Pyridyl)-Ala] SEQ ID NO: 62 K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[4- Aminopiperidin-4-carbonyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 63 K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)P[3-(3- Pyridyl)-Ala] SEQ ID NO: 64 K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[5- Aminopentanoyl][3-(3-Pyridyl)-Ala]SEQ ID NO: 65K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu][beta-hGlu](1c)SEQ ID NO: 66K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab]SEQ ID NO: 67K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab]SEQ ID NO: Sequence SEQ ID NO: 68 K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal]GE(1c)[Dab][3-(3-Pyridyl)- Ala] SEQ ID NO: 69 K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)H[3-(3- Pyridyl)-Ala] SEQ ID NO: 70 K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[{d}H][3- (3-Pyridyl)-Ala] SEQ ID NO: 71 K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[3-(3- Quinolinyl)-Ala][3-(3-Pyridyl)-Ala] SEQ ID NO: 72 K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[(R,S)- Imidazolidin-2-carbonyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 73 K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[H(1- Me)][3-(3-Pyridyl)-Ala] SEQ ID NO: 74 E(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu][K(Me)](1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 75 [N-Me-Lys](1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 76 K(1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][Dab](7c)E(1c)[Dab][3-(3- Pyridyl)-Ala](7c)^SEQ ID NO: 77 K(1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal]K(7c)E(1c)[Dab][3-(3- Pyridyl)-Ala](7c)^SEQ ID NO: 78 K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3- (3,5-Pyrimidyl)-Ala] SEQ ID NO: 79 K(1c)(6c)^[3-Aminopropanoyl][1-Me-Trp]QE(6c)[Y(2-aminoethoxy)][2- Nal][2-Me-Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 80 [N-Me-Lys](1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2-aminoethoxy)][2- Nal][2-Me-Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 81 K(1c)(6c)^[N-Me-3-Aminopropanoyl]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2- Me-Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 82 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Cyclopropyl-Ala][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 83 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[3-(3-Pyridyl)-Ala][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 84 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[3-(2-Pyridyl)-Ala][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 85 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[3-(4-Pyridyl)-Ala][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]SEQ ID NO: Sequence SEQ ID NO: 86 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)H[3-(3-Pyridyl)-Ala] SEQ ID NO: 87 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[3-(3-Pyridyl)-Ala][3-(3-Pyridyl)-Ala] SEQ ID NO: 88 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[3-(2-Pyridyl)-Ala][3-(3-Pyridyl)-Ala] SEQ ID NO: 89 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[3-(4-Pyridyl)-Ala][3-(3-Pyridyl)-Ala] SEQ ID NO: 90 [Orn](1c)(6c)^GWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] [Orn](1c ^ SEQ ID NO: 91 )(6c) [3-Aminopropanoyl]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2- Me-Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 92 [Dab](1c)(6c)^GWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 93 [hLys](1c)(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3- (3-Pyridyl)-Ala] SEQ ID NO: 94 [Dab](1c)(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3- (3-Pyridyl)-Ala] SEQ ID NO: 95 [Dpr](1c)(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3- (3-Pyridyl)-Ala] SEQ ID NO: 96 K(1c)(6c)^[beta-hIle]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] K(1c)( ^ SEQ ID NO: 97 6c) [beta-hThr]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 98 K(1c)(6c)^[4-Aminobutanoyl]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 99 [beta-hLys](1c)(6c)^GWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] EQ ID NO: 100 [beta-hLys](1c)(6c)^[beta-hTrp]QE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] EQ ID NO: 101 [beta-hLys](1c)(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] EQ ID NO: 102 [iso-Lys](1c)^(6c)WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] EQ ID NO: 103 [iso-Dab](1c)^(6c)WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]SEQ ID NO: Sequence SEQ ID NO: 104 [iso-Lys](1c)^(6c)GWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 105 [iso-Dab](1c)^(6c)GWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 106 [iso-Glu](1c)^(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]K(1c)[Dab][3-(3-Pyridyl)-Ala] [iso-Glu](1c)^(6c)^ SEQ ID NO: 107 WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu][Dab](1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 108 [{d}iso-Glu](1c)^(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]K(1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 109 [{d}iso-Glu](1c)^(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu][Dab](1c)[Dab][3-(3-Pyridyl)-Ala] SEQ ID NO: 110 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)W[2-Nal][2-Me-Leu]E(1c)[Dab][3- (3-Pyridyl)-Ala] SEQ ID NO: 111 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]W[Q(Me)]E(6c)[Y(2- aminoethoxy)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 112 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4-morpholine)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 113 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]W[2,4-Diaminobutanoyl(Ac-N- Me)]E(6c)[Y(2-aminoethoxy)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3- Pyridyl)-Ala] SEQ ID NO: 114 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]W[2,4- Diaminobutanoyl(Ac)]E(6c)[Y(2-aminoethoxy)][2Nal][Aib]E(1c)[2,4- Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 115 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2- aminoethoxy)][2Nal]{d}AE(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 116 {d}K(1c)(6c)^[3-Aminopropanoyl]WQ{d}E(6c)[Y(2-aminoethoxy)][2Nal][2- Me-Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]SEQ ID NO: Sequence SEQ ID NO: 117 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4-THP)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 118 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2- aminoethoxy)][2Nal][Aib]E(1c)[Ser(OCH3)][3-(3-Pyridyl)-Ala] SEQ ID NO: 119 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(CH3-2-F)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 120 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]W[2,4- Diaminobutanoyl(Ac)]E(6c)[Y(2- aminoethoxy)][2Nal][Aib]E(1c)[Ser(OCH3)][3-(3-Pyridyl)-Ala] SEQ ID NO: 121 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4- F)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 122 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4-piperazine)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 123 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4-imidazole)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 124 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(CH3-3-F)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 125 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2- aminoethoxy)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl] SEQ ID NO: 126 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4-piperidine)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 127 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[5- AzaTrp][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]SEQ ID NO: Sequence SEQ ID NO: 128 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(Ac-2-aminoethoxy)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 129 K(1c)(6c)^[N-Me-3-Aminopropanoyl]WQE(6c)[Y(2- aminoethoxy)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 130 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[7- AzaTrp][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 131 N-Me-Lys](1c)(6c)^[3-Aminopropanoyl]WQE(6c)[6- AzaTrp][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 132 N-Me-Lys-oxy-propanoyl(1c)(6c)^WQE(6c)[7- AzaTrp][2Nal][Aib]E(1c)[Ser(OCH3)][3-(3-Pyridyl)-Ala] SEQ ID NO: 133 N-Me-Lys](1c)(6c)^[3-Aminopropanoyl]W[2,4- Diaminobutanoyl(Ac)]E(6c)[Y(CH3)][2Nal][Aib]E(1c)[Ser(OCH3)][3-(3- Pyridyl)-Ala] SEQ ID NO: 134 K(1c)(6c^[3-Aminopropanoyl]WQE(6c)[F(4-F)][2Nal][2-Me-Leu]E(1c)[2,4- Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 135 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4- CONH2)][2Nal][Aib]E(1c)[Ser(OCH3)][3-(3-Pyridyl)-Ala] SEQ ID NO: 136 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2- aminoethoxy)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)- alanyl][3-Aminopropanoyl] SEQ ID NO: 137 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2- aminoethoxy)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]{d}H SEQ ID NO: 138 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2- aminoethoxy)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)- Ala]{d}WSEQ ID NO: Sequence SEQ ID NO: 139 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(CF3)][2Nal][2-Me-Leu]E(1c)[2,4- Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 140 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[7- AzaTrp][2Nal][Aib]E(1c)[Ser(OCH3)][3-(3-Pyridyl)-Ala] SEQ ID NO: 141 K(1c)(6c)^[3-Aminopropanoyl]WQ{d}E(6c)[Y(2-aminoethoxy)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala] SEQ ID NO: 142 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]W[Q(2Me)]E(6c)[7- AzaTrp][2Nal][Aib]E(1c)[Ser(OCH3)][3-(3-Pyridyl)-Ala] SEQ ID NO: 143 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4- morpholine)][2Nal][Aib]E(1c)[Ser(OCH3)][3-(3-Pyridyl)-Ala] SEQ ID NO: 144 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4-morpholine)][2Nal][2-Me- Leu]E(1c)[Ser(OCH3)][3-(3-Pyridyl)-Ala] SEQ ID NO: 145K(1c)(6c)^[3-Aminopropanoyl][7-Me-Trp][Q(2Me)]E(6c)[Y(2- aminoethoxy)(N(Me)2)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3- Pyridyl)-alanyl]-[NHMe] SEQ ID NO: 146K(1c)(6c)^[3-Aminopropanoyl][7MeTrp][Q(2Me)]E(6c)[Y(nPentylamine) (N+(Me)3)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-alanyl]- [NHMe] SEQ ID NO: 147 K(1c)(6c)^[3-Aminopropanoyl][7-Me-Trp][Q(2Me)]E(6c)[Y(2-trimethyl- PEG2)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-alanyl]-[NHMe] SEQ ID NO: 148K(1c)(6c)^[3-Aminopropanoyl][7-Me-Trp][K(NMePEG3)]E(6c)[Y(2- aminoethoxy)(N(Me)2)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3- Pyridyl)-alanyl]-[NHMe] wherein:^denotes that the (1c), (6c), (6g), and (7c) bridges use the alpha-amine group (or beta- amine group for bLys, {d}bLys and beta-hLys, or the alpha-amine converted into an azide group for (N3)-K and {d}(N3)-K) of the amino acid in the bridge^denotes that the (1c), (6c), (6g), and (7c) bridges use the alpha-carboxylic acid group of the amino acid in the bridge (1c) denotes the [2,11] lactam bridge; (6c) denotes the [2,7] lactam bridge; (6g) denotes the [2,7] 1,4-disubstituted 1,2,3-triazole bridge; (7c) denotes the [10,13] lactam bridge.

23. A compound according to claim 1 which is selected from: Compound Structure [{d}K](1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3- (3-Pyridyl)-Ala]-[NH2] 1 CC(C)C[C@]1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O CCN)cc2)NC(=O)[C@@H]2CCC(=O)N[C@H](CCCCNC(=O)CC[C@@H](C( =O)N[C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(N)=O)NC1=O)C(=O)N[C @@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]c3 ccccc13)C(=O)N[C@@H](CCC(N)=O)C(=O)N2 K(1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3- Pyridyl)-Ala]-[NH2] 2 CC(C)C[C@]1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O CCN)cc2)NC(=O)[C@@H]2CCC(=O)N[C@@H](CCCCNC(=O)CC[C@@H]( C(=O)N[C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(N)=O)NC1=O)C(=O) N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH ]c3ccccc13)C(=O)N[C@@H](CCC(N)=O)C(=O)N2 [{d}K](1c)(6c)^TVWQD(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3- (3-Pyridyl)-Ala]-[NH2] 3 CC(C)C[C@]1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O CCN)cc2)NC(=O)[C@@H]2CC(=O)N[C@H](CCCCNC(=O)CC[C@@H](C(= O)N[C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(N)=O)NC1=O)C(=O)N[C @@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]c3 ccccc13)C(=O)N[C@@H](CCC(N)=O)C(=O)N2 [hLys](1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3- (3-Pyridyl)-Ala]-[NH2] 4 CC(C)C[C@]1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O CCN)cc2)NC(=O)[C@@H]2CCC(=O)N[C@@H](CCCCCNC(=O)CC[C@@H] (C(=O)N[C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(N)=O)NC1=O)C(=O) N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH ]c3ccccc13)C(=O)N[C@@H](CCC(N)=O)C(=O)N2Compound Structure [{d}hLys](1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NH2] 5 CC(C)C[C@]1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O CCN)cc2)NC(=O)[C@@H]2CCC(=O)N[C@H](CCCCCNC(=O)CC[C@@H](C (=O)N[C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(N)=O)NC1=O)C(=O)N[ C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]c 3ccccc13)C(=O)N[C@@H](CCC(N)=O)C(=O)N2 [{d}Orn](1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu][hGlu](1c)[Dab][3-(3-Pyridyl)-Ala]-[NH2] 6 CC(C)C[C@]1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O CCN)cc2)NC(=O)[C@@H]2CCC(=O)N[C@H](CCCNC(=O)CCC[C@@H](C( =O)N[C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(N)=O)NC1=O)C(=O)N[C @@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]c3 ccccc13)C(=O)N[C@@H](CCC(N)=O)C(=O)N2 [{d}Dab](1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu][2-Amino-6- carboxyhexanoyl](1c)[Dab][3-(3-Pyridyl)-Ala]-[NH2] 7 CC(C)C[C@]1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O CCN)cc2)NC(=O)[C@@H]2CCC(=O)N[C@H](CCNC(=O)CCCC[C@@H](C( =O)N[C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(N)=O)NC1=O)C(=O)N[C @@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]c3 ccccc13)C(=O)N[C@@H](CCC(N)=O)C(=O)N2 [{d}Orn](1c)(6c)^TVWQD(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu][hGlu](1c)[Dab][3-(3-Pyridyl)-Ala]-[NH2] 8 CC(C)C[C@]1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O CCN)cc2)NC(=O)[C@@H]2CC(=O)N[C@H](CCCNC(=O)CCC[C@@H](C(= O)N[C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(N)=O)NC1=O)C(=O)N[C @@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]c3 ccccc13)C(=O)N[C@@H](CCC(N)=O)C(=O)N2 [{d}Dab](1c)(6c)^TVWQD(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu][2-Amino- 6-carboxyhexanoyl](1c)[Dab][3-(3-Pyridyl)-Ala]-[NH2] 9 CC(C)C[C@]1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O CCN)cc2)NC(=O)[C@@H]2CC(=O)N[C@H](CCNC(=O)CCCC[C@@H](C(= O)N[C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(N)=O)NC1=O)C(=O)N[C @@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]c3 ccccc13)C(=O)N[C@@H](CCC(N)=O)C(=O)N2 [{d}Orn](1c)(6c)^TVWQD(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NH2] 10 CC(C)C[C@]1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O CCN)cc2)NC(=O)[C@@H]2CC(=O)N[C@H](CCCNC(=O)CC[C@@H](C(=O) N[C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(N)=O)NC1=O)C(=O)N[C@ @H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]c3cc ccc13)C(=O)N[C@@H](CCC(N)=O)C(=O)N2Compound Structure [{d}Dab](1c)(6c)^TVWQD(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NH2] 11 CC(C)C[C@]1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O CCN)cc2)NC(=O)[C@@H]2CC(=O)N[C@H](CCNC(=O)CC[C@@H](C(=O)N [C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(N)=O)NC1=O)C(=O)N[C@@ H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]c3cccc c13)C(=O)N[C@@H](CCC(N)=O)C(=O)N2 [bLys](1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3- (3-Pyridyl)-Ala]-[NH2] 12 CC(C)C[C@]1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O CCN)cc2)NC(=O)[C@@H]2CCC(=O)N[C@@H](CCCNC(=O)CC[C@@H](C( =O)N[C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(N)=O)NC1=O)CC(=O)N[ C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]c 3ccccc13)C(=O)N[C@@H](CCC(N)=O)C(=O)N2 [{d}bLys](1c)(6c)^TWQD(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NH2] 13 CC(C)C[C@]1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O CCN)cc2)NC(=O)[C@@H]2CC(=O)N[C@H](CCCNC(=O)CC[C@@H](C(=O) N[C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(N)=O)NC1=O)CC(=O)N[C@ @H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H]( CCC(N)=O)C(=O)N2 [{d}bLys](1c)(6c)^TWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NH2] 14 CC(C)C[C@]1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O CCN)cc2)NC(=O)[C@@H]2CCC(=O)N[C@H](CCCNC(=O)CC[C@@H](C(= O)N[C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(N)=O)NC1=O)CC(=O)N[ C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@ H](CCC(N)=O)C(=O)N2 [{d}Dab](1c)(6c)^TWQD(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu][2-Amino-6- carboxyhexanoyl](1c)[Dab][3-(3-Pyridyl)-Ala]-[NH2] 15 CC(C)C[C@]1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O CCN)cc2)NC(=O)[C@@H]2CC(=O)N[C@H](CCNC(=O)CCCC[C@@H](C(= O)N[C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(N)=O)NC1=O)C(=O)N[C @@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H] (CCC(N)=O)C(=O)N2 K(1c)(6c)^IVWQE(6c)[F(4-Me)][2-Nal][2-Me-Val]E(1c)[Dab][3-(3-Pyridyl)-Ala]- [NH2] 16 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N [C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(N)=O)NC(=O)[C@](C)(C(C)C )NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(C)cc3)NC(=O)[C@ H](CCC(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc2 3)NC(=O)[C@H](C(C)C)NC1=O K(1c)(6c)^IVWQE(6c)[F(4-Me)][2-Nal][Aib]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NH2] CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N 17 [C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(N)=O)NC(=O)C(C)(C)NC(=O) [C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(C)cc3)NC(=O)[C@H](CCC( =O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(= O)[C@H](C(C)C)NC1=OCompound Structure K(1c)(6c)^IVWQE(6c)[F(4-Me)][2-Nal][2-Me-Val]E(1c)[Dab][{d}3-(3-Pyridyl)- Ala]-[NH2] 18 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N [C@@H](CCN)C(=O)N[C@H](Cc3cccnc3)C(N)=O)NC(=O)[C@](C)(C(C)C)N C(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(C)cc3)NC(=O)[C@H] (CCC(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23) NC(=O)[C@H](C(C)C)NC1=O K(1c)(6c)^IVWQE(6c)[F(4-Me)][2-Nal][2-Me-Val]E(1c)G[{d}3-(3-Pyridyl)-Ala]- [NH2] 19 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N CC(=O)N[C@H](Cc3cccnc3)C(N)=O)NC(=O)[C@](C)(C(C)C)NC(=O)[C@H]( Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(C)cc3)NC(=O)[C@H](CCC(=O)N2) NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H ](C(C)C)NC1=O K(1c)(6c)^IVWQE(6c)[Cyclopropyl-Ala][2-Nal][2-Me-Val]E(1c)G[{d}3-(3- Pyridyl)-Ala]-[NH2] 20 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N CC(=O)N[C@H](Cc3cccnc3)C(N)=O)NC(=O)[C@](C)(C(C)C)NC(=O)[C@H]( Cc3ccc4ccccc4c3)NC(=O)[C@H](CC3CC3)NC(=O)[C@H](CCC(=O)N2)NC( =O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C( C)C)NC1=O K(1c)(6c)^IVWQE(6c)[2-Me-Phe][2-Nal][2-Me-Val]E(1c)G[{d}3-(3-Pyridyl)- Ala]-[NH2] 21 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N CC(=O)N[C@H](Cc3cccnc3)C(N)=O)NC(=O)[C@](C)(C(C)C)NC(=O)[C@H]( Cc3ccc4ccccc4c3)NC(=O)[C@](C)(Cc3ccccc3)NC(=O)[C@H](CCC(=O)N2)N C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]( C(C)C)NC1=O K(1c)(6c)^IVWQE(6c)[{d}F][2-Nal][2-Me-Val]E(1c)G[{d}3-(3-Pyridyl)-Ala]- [NH2] 22 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N CC(=O)N[C@H](Cc3cccnc3)C(N)=O)NC(=O)[C@](C)(C(C)C)NC(=O)[C@H]( Cc3ccc4ccccc4c3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](CCC(=O)N2) NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H ](C(C)C)NC1=O K(1c)(6c)^IVWQE(6c)[F(4-Me)][Cyclopropyl-Ala][2-Me-Val]E(1c)G[{d}3-(3- Pyridyl)-Ala]-[NH2] 23 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N CC(=O)N[C@H](Cc3cccnc3)C(N)=O)NC(=O)[C@](C)(C(C)C)NC(=O)[C@H]( CC3CC3)NC(=O)[C@H](Cc3ccc(C)cc3)NC(=O)[C@H](CCC(=O)N2)NC(=O)[ C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C(C)C) NC1=OCompound Structure K(1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu][iso-Dab](1c)^-[3- pyridylpropionyl] 24 Cc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC(=O)N[C@@H](CCCCNC(=O)[C @@H](NC(=O)CCc4cccnc4)CCNC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc4 ccc5ccccc5c4)NC2=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C )C)C(=O)N[C@@H](Cc2c[nH]c4ccccc24)C(=O)N[C@@H](CCC(N)=O)C(=O) N3)cc1 K(1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu][iso-Dab](1c)^-[6- (3-pyridyl)hexanoyl] 25 Cc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC(=O)N[C@@H](CCCCNC(=O)[C @@H](NC(=O)CCCCCc4cccnc4)CCNC(=O)[C@](C)(CC(C)C)NC(=O)[C@H] (Cc4ccc5ccccc5c4)NC2=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H] (C(C)C)C(=O)N[C@@H](Cc2c[nH]c4ccccc24)C(=O)N[C@@H](CCC(N)=O)C (=O)N3)cc1 K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Val]E(1c)-[NH-2- (pyridin-3-yl)ethyl] 26 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N CCc3cccnc3)NC(=O)[C@](C)(C(C)C)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(= O)[C@H](Cc3ccc(OCCN)cc3)NC(=O)[C@H](CCC(=O)N2)NC(=O)[C@H](CC C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C(C)C)NC1=O K(1c)(6c)^IVWQ[{d}E](6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Val]E(1c)-[NH-2- (pyridin-3-yl)ethyl] 27 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N CCc3cccnc3)NC(=O)[C@](C)(C(C)C)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(= O)[C@H](Cc3ccc(OCCN)cc3)NC(=O)[C@@H](CCC(=O)N2)NC(=O)[C@H]( CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C(C)C)NC1= O K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Val]E(1c)-[NH-4- (pyridin-3-yl)butanyl] 28 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N CCCCc3cccnc3)NC(=O)[C@](C)(C(C)C)NC(=O)[C@H](Cc3ccc4ccccc4c3)N C(=O)[C@H](Cc3ccc(OCCN)cc3)NC(=O)[C@H](CCC(=O)N2)NC(=O)[C@H]( CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C(C)C)NC1= O K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Val]E(1c)-[NH-6- (pyridin-3-yl)hexanyl] 29 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N CCCCCCc3cccnc3)NC(=O)[C@](C)(C(C)C)NC(=O)[C@H](Cc3ccc4ccccc4c3 )NC(=O)[C@H](Cc3ccc(OCCN)cc3)NC(=O)[C@H](CCC(=O)N2)NC(=O)[C@ H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C(C)C)NC 1=O K(1c)(6c)^SVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)-[NH-4- (pyridin-3-yl)butanyl] 30 CC(C)C[C@]1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O CCN)cc2)NC(=O)[C@@H]2CCC(=O)N[C@@H](CCCCNC(=O)CC[C@@H]( C(=O)NCCCCc3cccnc3)NC1=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C) C)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCC(N)=O)C(=O) N2Compound Structure K(1c)(6c)^SVWQE(6c)[Y(2-aminoethoxy)][2-Nal]GE(1c)-[NH-4-(pyridin-3- yl)butanyl] 31 CC(C)[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCCNC(=O)CC[C@ @H](C(=O)NCCCCc3cccnc3)NC(=O)CNC(=O)[C@H](Cc3ccc4ccccc4c3)NC( =O)[C@H](Cc3ccc(OCCN)cc3)NC(=O)[C@H](CCC(=O)N2)NC(=O)[C@H](C CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O K(1c)(6c)^IVWQE(6c)[Y(nPr)][2-Nal][2-Me-Leu]E(1c)-[NH-4-(pyridin-3- yl)butanyl] 32 CCCOc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC(=O)N[C@@H](CCCCNC(= O)CC[C@@H](C(=O)NCCCCc4cccnc4)NC(=O)[C@](C)(CC(C)C)NC(=O)[C @H](Cc4ccc5ccccc5c4)NC2=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C @@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]c4ccccc24)C(=O)N[C@@H](CCC( N)=O)C(=O)N3)cc1 K(1c)(6c)^IVWQE(6c)[F(4-Bu)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]- [NHMe] 33 CCCCc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC(=O)N[C@@H](CCCCNC(= O)CC[C@@H](C(=O)N[C@@H](CCN)C(=O)N[C@@H](Cc4cccnc4)C(=O)N C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc4ccc5ccccc5c4)NC2=O)C(=O) N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[n H]c4ccccc24)C(=O)N[C@@H](CCC(N)=O)C(=O)N3)cc1 K(1c)(6c)^IVWQE(6c)[Y(Bn)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]- [NHMe] 34 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N [C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(=O)NC)NC(=O)[C@](C)(CC( C)C)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCc4ccccc4)c c3)NC(=O)[C@H](CCC(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc 2c[nH]c3ccccc23)NC(=O)[C@H](C(C)C)NC1=O K(1c)(6c)^IVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]- [NHMe] 35 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N [C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(=O)NC)NC(=O)[C@](C)(CC( C)C)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OC)cc3)NC(= O)[C@H](CCC(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3 ccccc23)NC(=O)[C@H](C(C)C)NC1=O K(1c)(6c)^TWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3- Pyridyl)-Ala]-[NHMe] 36 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]([C@@H](C)O)NC2=O)C(=O)N[C@@ H](Cc2ccc(OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C )(CC(C)C)C(=O)N1 [Dab](1c)(6c)^TWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3- (3-Pyridyl)-Ala]-[NHMe] 37 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]( Cc3c[nH]c4ccccc34)NC(=O)[C@H]([C@@H](C)O)NC2=O)C(=O)N[C@@H]( Cc2ccc(OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(C C(C)C)C(=O)N1Compound Structure K(1c)(6c)^TWQ[hGlu](6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3- (3-Pyridyl)-Ala]-[NHMe] 38 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C @H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]([C@@H](C)O)NC2=O)C(=O)N[C@ @H](Cc2ccc(OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@]( C)(CC(C)C)C(=O)N1 E(1c)(6c)^TWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]K(1c)[Dab][3-(3- Pyridyl)-Ala]-[NHMe] 39 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCCCN C(=O)CC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C @H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]([C@@H](C)O)NC2=O)C(=O)N[C@ @H](Cc2ccc(OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@]( C)(CC(C)C)C(=O)N1 E(1c)(6c)^TWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu][Orn](1c)[Dab][3-(3- Pyridyl)-Ala]-[NHMe] 40 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCCNC( =O)CC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H ](Cc3c[nH]c4ccccc34)NC(=O)[C@H]([C@@H](C)O)NC2=O)C(=O)N[C@@H] (Cc2ccc(OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)( CC(C)C)C(=O)N1 [(N3)-K](1c)(6g)^TWQ[Pra](6g)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 41 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@H]2C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc3c[nH]c 4ccccc34)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc3cn2nn3)C(=O)N [C@@H](Cc2ccc(OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C @@](C)(CC(C)C)C(=O)N1 [{d}(N3)-K](1c)(6g)^TWQ[Hpg](6g)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 42 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc3c[nH ]c4ccccc34)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCc3cn2nn3)C(= O)N[C@@H](Cc2ccc(OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O) N[C@@](C)(CC(C)C)C(=O)N1 K(1c)(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3- Pyridyl)-Ala]-[NHMe] 43 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC2=O)C(=O)N[C@@H](Cc2ccc(OCCN)cc2)C(=O)N [C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 K(1c)(6c)^GWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3- Pyridyl)-Ala]-[NHMe] 44 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)C(=O)N[C@@H](Cc2ccc(OCCN)cc 2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1Compound Structure K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 45 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc(OCCN)c c2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 [K(G)](1c)(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3- Pyridyl)-Ala]-[NHMe] 46 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCC(=O)NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC (=O)[C@H](Cc3c[nH]c4ccccc34)NC2=O)C(=O)N[C@@H](Cc2ccc(OCCN)cc 2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(piconilate)]-[NH2] COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC(=O)N[C@@H](CCCCNC(=O)C 47 C[C@@H](C(=O)N[C@@H](CCCCNC(=O)c4ccccn4)C(N)=O)NC(=O)[C@]( C)(CC(C)C)NC(=O)[C@H](Cc4ccc5ccccc5c4)NC2=O)C(=O)N[C@@H]([C@ @H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]c4ccccc24)C(= O)N[C@@H](CCC(N)=O)C(=O)N3)cc1 K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(2-pyridylacetyl)]- [NH2] 48 COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC(=O)N[C@@H](CCCCNC(=O)C C[C@@H](C(=O)N[C@@H](CCCCNC(=O)Cc4ccccn4)C(N)=O)NC(=O)[C@] (C)(CC(C)C)NC(=O)[C@H](Cc4ccc5ccccc5c4)NC2=O)C(=O)N[C@@H]([C@ @H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]c4ccccc24)C(= O)N[C@@H](CCC(N)=O)C(=O)N3)cc1 K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(2-pyridylpropionyl)]- [NH2] 49 COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC(=O)N[C@@H](CCCCNC(=O)C C[C@@H](C(=O)N[C@@H](CCCCNC(=O)CCc4ccccn4)C(N)=O)NC(=O)[C @](C)(CC(C)C)NC(=O)[C@H](Cc4ccc5ccccc5c4)NC2=O)C(=O)N[C@@H]([ C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]c4ccccc24) C(=O)N[C@@H](CCC(N)=O)C(=O)N3)cc1 K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(nicotinate)]-[NH2] COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC(=O)N[C@@H](CCCCNC(=O)C 50 C[C@@H](C(=O)N[C@@H](CCCCNC(=O)c4cccnc4)C(N)=O)NC(=O)[C@]( C)(CC(C)C)NC(=O)[C@H](Cc4ccc5ccccc5c4)NC2=O)C(=O)N[C@@H]([C@ @H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]c4ccccc24)C(= O)N[C@@H](CCC(N)=O)C(=O)N3)cc1 K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(3-pyridylacetyl)]- [NH2] 51 COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC(=O)N[C@@H](CCCCNC(=O)C C[C@@H](C(=O)N[C@@H](CCCCNC(=O)Cc4cccnc4)C(N)=O)NC(=O)[C@] (C)(CC(C)C)NC(=O)[C@H](Cc4ccc5ccccc5c4)NC2=O)C(=O)N[C@@H]([C@ @H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]c4ccccc24)C(= O)N[C@@H](CCC(N)=O)C(=O)N3)cc1Compound Structure K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(3-pyridylpropionyl)]- [NH2] 52 COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC(=O)N[C@@H](CCCCNC(=O)C C[C@@H](C(=O)N[C@@H](CCCCNC(=O)CCc4cccnc4)C(N)=O)NC(=O)[C @](C)(CC(C)C)NC(=O)[C@H](Cc4ccc5ccccc5c4)NC2=O)C(=O)N[C@@H]([ C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]c4ccccc24) C(=O)N[C@@H](CCC(N)=O)C(=O)N3)cc1 K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(isonicotinyl)]-[NH2] COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC(=O)N[C@@H](CCCCNC(=O)C 53 C[C@@H](C(=O)N[C@@H](CCCCNC(=O)c4ccncc4)C(N)=O)NC(=O)[C@]( C)(CC(C)C)NC(=O)[C@H](Cc4ccc5ccccc5c4)NC2=O)C(=O)N[C@@H]([C@ @H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]c4ccccc24)C(= O)N[C@@H](CCC(N)=O)C(=O)N3)cc1 K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(4-pyridylacetyl)]- [NH2] 54 COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC(=O)N[C@@H](CCCCNC(=O)C C[C@@H](C(=O)N[C@@H](CCCCNC(=O)Cc4ccncc4)C(N)=O)NC(=O)[C@] (C)(CC(C)C)NC(=O)[C@H](Cc4ccc5ccccc5c4)NC2=O)C(=O)N[C@@H]([C@ @H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]c4ccccc24)C(= O)N[C@@H](CCC(N)=O)C(=O)N3)cc1 K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(4-pyridylpropionyl)]- [NH2] 55 COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC(=O)N[C@@H](CCCCNC(=O)C C[C@@H](C(=O)N[C@@H](CCCCNC(=O)CCc4ccncc4)C(N)=O)NC(=O)[C @](C)(CC(C)C)NC(=O)[C@H](Cc4ccc5ccccc5c4)NC2=O)C(=O)N[C@@H]([ C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]c4ccccc24) C(=O)N[C@@H](CCC(N)=O)C(=O)N3)cc1 K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(3,5-pyrimidine)]- [NH2] 56 COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC(=O)N[C@@H](CCCCNC(=O)C C[C@@H](C(=O)N[C@@H](CCCCNC(=O)c4cncnc4)C(N)=O)NC(=O)[C@]( C)(CC(C)C)NC(=O)[C@H](Cc4ccc5ccccc5c4)NC2=O)C(=O)N[C@@H]([C@ @H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]c4ccccc24)C(= O)N[C@@H](CCC(N)=O)C(=O)N3)cc1 K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(4-pyridyl-3- fluoroacetyl)]-[NH2] 57 COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC(=O)N[C@@H](CCCCNC(=O)C C[C@@H](C(=O)N[C@@H](CCCCNC(=O)Cc4ccnc(F)c4)C(N)=O)NC(=O)[C @](C)(CC(C)C)NC(=O)[C@H](Cc4ccc5ccccc5c4)NC2=O)C(=O)N[C@@H]([ C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]c4ccccc24) C(=O)N[C@@H](CCC(N)=O)C(=O)N3)cc1 K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(Imidazoleacetyl)]- [NH2] 58 COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC(=O)N[C@@H](CCCCNC(=O)C C[C@@H](C(=O)N[C@@H](CCCCNC(=O)Cc4ncc[nH]4)C(N)=O)NC(=O)[C @](C)(CC(C)C)NC(=O)[C@H](Cc4ccc5ccccc5c4)NC2=O)C(=O)N[C@@H]([ C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]c4ccccc24) C(=O)N[C@@H](CCC(N)=O)C(=O)N3)cc1Compound Structure K(1c)(6c)^TVWQE(6c)[Y(Me)][2-Nal][2-Me-Leu]E(1c)[K(Imidazolepropanoyl)]- [NH2] 59 COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC(=O)N[C@@H](CCCCNC(=O)C C[C@@H](C(=O)N[C@@H](CCCCNC(=O)CCc4ncc[nH]4)C(N)=O)NC(=O)[C @](C)(CC(C)C)NC(=O)[C@H](Cc4ccc5ccccc5c4)NC2=O)C(=O)N[C@@H]([ C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]c4ccccc24) C(=O)N[C@@H](CCC(N)=O)C(=O)N3)cc1 K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3- Pyridyl)-Ala]-[NHMe] 60 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N [C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(=O)NC)NC(=O)[C@](C)(CC( C)C)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCCN)cc3)NC (=O)[C@H](CCC(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH] c3ccccc23)NC(=O)[C@H](C(C)C)NC1=O K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu][beta-hGlu](1c)[3- (3-Pyridyl)-Ala]-[NHMe] 61 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](CC(=O) N[C@@H](Cc3cccnc3)C(=O)NC)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc 3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCCN)cc3)NC(=O)[C@H](CCC(=O) N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C @H](C(C)C)NC1=O K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[4- Aminopiperidin-4-carbonyl][3-(3-Pyridyl)-Ala]-[NHMe] 62 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N C3(C(=O)N[C@@H](Cc4cccnc4)C(=O)NC)CCNCC3)NC(=O)[C@](C)(CC(C) C)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCCN)cc3)NC(= O)[C@H](CCC(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3 ccccc23)NC(=O)[C@H](C(C)C)NC1=O K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)P[3-(3- Pyridyl)-Ala]-[NHMe] 63 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N 3CCC[C@H]3C(=O)N[C@@H](Cc3cccnc3)C(=O)NC)NC(=O)[C@](C)(CC(C) C)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCCN)cc3)NC(= O)[C@H](CCC(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3 ccccc23)NC(=O)[C@H](C(C)C)NC1=O K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[5- Aminopentanoyl][3-(3-Pyridyl)-Ala]-[NHMe] 64 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N CCCCC(=O)N[C@@H](Cc3cccnc3)C(=O)NC)NC(=O)[C@](C)(CC(C)C)NC(= O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCCN)cc3)NC(=O)[C@ H](CCC(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc2 3)NC(=O)[C@H](C(C)C)NC1=OCompound Structure K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu][beta-hGlu](1c)- [NH-2-(pyridin-3-yl)ethyl] 65 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](CC(=O) NCCc3cccnc3)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc3ccc4ccccc4c3)N C(=O)[C@H](Cc3ccc(OCCN)cc3)NC(=O)[C@H](CCC(=O)N2)NC(=O)[C@H]( CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C(C)C)NC1= O K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab]-[NH-2- (pyridin-3-yl)ethyl] 66 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N [C@@H](CCN)C(=O)NCCc3cccnc3)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H] (Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCCN)cc3)NC(=O)[C@H](CCC(= O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O) [C@H](C(C)C)NC1=O K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab]-[NH-3- (pyridin-3-yl)propyl] 67 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N [C@@H](CCN)C(=O)NCCCc3cccnc3)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@ H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCCN)cc3)NC(=O)[C@H](CCC (=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(= O)[C@H](C(C)C)NC1=O K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal]GE(1c)[Dab][3-(3-Pyridyl)- Ala]-[NHMe] 68 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N [C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(=O)NC)NC(=O)CNC(=O)[C@ H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCCN)cc3)NC(=O)[C@H](CCC (=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(= O)[C@H](C(C)C)NC1=O K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)H[3-(3- Pyridyl)-Ala]-[NHMe] 69 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N [C@@H](Cc3cnc[nH]3)C(=O)N[C@@H](Cc3cccnc3)C(=O)NC)NC(=O)[C@]( C)(CC(C)C)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCCN) cc3)NC(=O)[C@H](CCC(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C c2c[nH]c3ccccc23)NC(=O)[C@H](C(C)C)NC1=O K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[{d}H][3-(3- Pyridyl)-Ala]-[NHMe] 70 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N [C@H](Cc3cnc[nH]3)C(=O)N[C@@H](Cc3cccnc3)C(=O)NC)NC(=O)[C@](C) (CC(C)C)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCCN)cc 3)NC(=O)[C@H](CCC(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2 c[nH]c3ccccc23)NC(=O)[C@H](C(C)C)NC1=OCompound Structure K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[3-(3- Quinolinyl)-Ala][3-(3-Pyridyl)-Ala]-[NHMe] 71 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N [C@@H](Cc3cnc4ccccc4c3)C(=O)N[C@@H](Cc3cccnc3)C(=O)NC)NC(=O)[ C@](C)(CC(C)C)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(O CCN)cc3)NC(=O)[C@H](CCC(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C @H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C(C)C)NC1=O K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[(R,S)- Imidazolidin-2-carbonyl][3-(3-Pyridyl)-Ala]-[NHMe] 72 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N 3CCNC3C(=O)N[C@@H](Cc3cccnc3)C(=O)NC)NC(=O)[C@](C)(CC(C)C)N C(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCCN)cc3)NC(=O)[ C@H](CCC(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3cc ccc23)NC(=O)[C@H](C(C)C)NC1=O K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[H(1-Me)][3- (3-Pyridyl)-Ala]-[NHMe] 73 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N [C@@H](Cc3cn(C)cn3)C(=O)N[C@@H](Cc3cccnc3)C(=O)NC)NC(=O)[C@]( C)(CC(C)C)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCCN) cc3)NC(=O)[C@H](CCC(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C c2c[nH]c3ccccc23)NC(=O)[C@H](C(C)C)NC1=O E(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu][K(Me)](1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 74 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCC(=O)N(C)CCCC[C@@H](C(= O)N[C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(=O)NC)NC(=O)[C@](C)( CC(C)C)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCCN)cc3 )NC(=O)[C@H](CCC(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c [nH]c3ccccc23)NC(=O)[C@H](C(C)C)NC1=O [N-Me-Lys](1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 75 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N [C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(=O)NC)NC(=O)[C@](C)(CC( C)C)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCCN)cc3)NC (=O)[C@H](CCC(=O)N2C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[n H]c3ccccc23)NC(=O)[C@H](C(C)C)NC1=O K(1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal][Dab](7c)E(1c)[Dab][3-(3- Pyridyl)-Ala](7c)^ 76 CC(C)[C@@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CCCCNC(= O)CC[C@@H]3NC(=O)[C@H](CCNC(=O)[C@H](Cc4cccnc4)NC(=O)[C@H]( CCN)NC3=O)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCC N)cc3)NC(=O)[C@H](CCC(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H] (Cc2c[nH]c3ccccc23)NC1=OCompound Structure K(1c)(6c)^TVWQE(6c)[Y(2-aminoethoxy)][2-Nal]K(7c)E(1c)[Dab][3-(3- Pyridyl)-Ala](7c)^ 77 CC(C)[C@@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CCCCNC(= O)CC[C@@H]3NC(=O)[C@H](CCCCNC(=O)[C@H](Cc4cccnc4)NC(=O)[C @H](CCN)NC3=O)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc( OCCN)cc3)NC(=O)[C@H](CCC(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C @H](Cc2c[nH]c3ccccc23)NC1=O K(1c)(6c)^IVWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3,5- Pyrimidyl)-Ala]-[NHMe] 78 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N [C@@H](CCN)C(=O)N[C@@H](Cc3cncnc3)C(=O)NC)NC(=O)[C@](C)(CC( C)C)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCCN)cc3)NC (=O)[C@H](CCC(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH] c3ccccc23)NC(=O)[C@H](C(C)C)NC1=O K(1c)(6c)^[3-Aminopropanoyl][1-Me-Trp]QE(6c)[Y(2-aminoethoxy)][2-Nal][2- Me-Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 79 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3cn(C)c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc(OCCN) cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N 1 [N-Me-Lys](1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2- Me-Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 80 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@H]2C(=O)NCCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C @@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)N2C)C(=O)N[C@@H](Cc2ccc (OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C) C(=O)N1 K(1c)(6c)^[N-Me-3-Aminopropanoyl]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2- Me-Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 81 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCN(C)C2=O)C(=O)N[C@@H](Cc2ccc(OCC N)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O) N1 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Cyclopropyl-Ala][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 82 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](CC2CC2)C(=O) N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[3-(3-Pyridyl)-Ala][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 83 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2cccnc2)C(= O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1Compound Structure K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[3-(2-Pyridyl)-Ala][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 84 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccccn2)C(= O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[3-(4-Pyridyl)-Ala][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 85 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccncc2)C(= O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)H[3-(3-Pyridyl)-Ala]-[NHMe] 86 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1 CCC(=O)NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC (=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc (OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C) C(=O)N1 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[3-(3-Pyridyl)-Ala][3-(3-Pyridyl)-Ala]-[NHMe] 87 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](Cc1cccnc1)NC(=O)[C@@H]1CC C(=O)NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(= O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc( OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C) C(=O)N1 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[3-(2-Pyridyl)-Ala][3-(3-Pyridyl)-Ala]-[NHMe] 88 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](Cc1ccccn1)NC(=O)[C@@H]1CC C(=O)NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(= O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc( OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C) C(=O)N1 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[3-(4-Pyridyl)-Ala][3-(3-Pyridyl)-Ala]-[NHMe] 89 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@@H]1CC C(=O)NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(= O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc( OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C) C(=O)N1 [Orn](1c)(6c)^GWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3- (3-Pyridyl)-Ala]-[NHMe] 90 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H] (Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)C(=O)N[C@@H](Cc2ccc(OCCN)cc2) C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1Compound Structure [Orn](1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 91 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H] (Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc(OCCN)cc2 )C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 [Dab](1c)(6c)^GWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3- (3-Pyridyl)-Ala]-[NHMe] 92 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]( Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)C(=O)N[C@@H](Cc2ccc(OCCN)cc2)C (=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 [hLys](1c)(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3- Pyridyl)-Ala]-[NHMe] 93 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C @H](Cc3c[nH]c4ccccc34)NC2=O)C(=O)N[C@@H](Cc2ccc(OCCN)cc2)C(=O )N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 [Dab](1c)(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3- Pyridyl)-Ala]-[NHMe] 94 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]( Cc3c[nH]c4ccccc34)NC2=O)C(=O)N[C@@H](Cc2ccc(OCCN)cc2)C(=O)N[C @@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 [Dpr](1c)(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3-(3- Pyridyl)-Ala]-[NHMe] 95 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C c3c[nH]c4ccccc34)NC2=O)C(=O)N[C@@H](Cc2ccc(OCCN)cc2)C(=O)N[C@ @H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 K(1c)(6c)^[beta-hIle]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 96 CC[C@H](C)[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H ](CCC(N)=O)C(=O)N[C@H]2CCC(=O)N[C@@H](CCCCNC(=O)CC[C@@H]( C(=O)N[C@@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(=O)NC)NC(=O)[C@]( C)(CC(C)C)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccc(OCCN) cc3)NC2=O)C(=O)N1 K(1c)(6c)^[beta-hThr]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 97 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)C[C@H]([C@@H](C)O)NC2=O)C(=O)N[C@ @H](Cc2ccc(OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@]( C)(CC(C)C)C(=O)N1Compound Structure K(1c)(6c)^[4-Aminobutanoyl]WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 98 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCCNC2=O)C(=O)N[C@@H](Cc2ccc(OCCN )cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N 1 [beta-hLys](1c)(6c)^GWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 99 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@H]2CC(=O)NCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C @@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)N2)C(=O)N[C@@H](Cc2ccc( OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C) C(=O)N1 [beta-hLys](1c)(6c)^[beta-hTrp]QE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 100 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)CC(=O)N[C@@H](C CC(N)=O)C(=O)N[C@@H](CCC(=O)N2)C(=O)N[C@@H](Cc2ccc(OCCN)cc 2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 [beta-hLys](1c)(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 101 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC C(N)=O)C(=O)N[C@@H](CCC(=O)N2)C(=O)N[C@@H](Cc2ccc(OCCN)cc2) C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 [iso-Lys](1c)^(6c)WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3- (3-Pyridyl)-Ala]-[NHMe] 102 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) N[C@H]2CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]( Cc3c[nH]c4ccccc34)NC2=O)C(=O)N[C@@H](Cc2ccc(OCCN)cc2)C(=O)N[C @@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 [iso-Dab](1c)^(6c)WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]E(1c)[Dab][3- (3-Pyridyl)-Ala]-[NHMe] 103 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) N[C@H]2CCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc 3c[nH]c4ccccc34)NC2=O)C(=O)N[C@@H](Cc2ccc(OCCN)cc2)C(=O)N[C@ @H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 [iso-Lys](1c)^(6c)GWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 104 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) N[C@H]2CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]( Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)C(=O)N[C@@H](Cc2ccc(OCCN)cc2)C (=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1Compound Structure [iso-Dab](1c)^(6c)GWQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]E(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 105 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) N[C@H]2CCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc 3c[nH]c4ccccc34)NC(=O)CNC2=O)C(=O)N[C@@H](Cc2ccc(OCCN)cc2)C(= O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 [iso-Glu](1c)^(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me-Leu]K(1c)[Dab][3- (3-Pyridyl)-Ala]-[NHMe] 106 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCCCN C(=O)[C@@H]2CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C CC(N)=O)C(=O)N[C@@H](CCC(=O)N2)C(=O)N[C@@H](Cc2ccc(OCCN)cc 2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 [iso-Glu](1c)^(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu][Dab](1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 107 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCNC(= O)[C@@H]2CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCC (N)=O)C(=O)N[C@@H](CCC(=O)N2)C(=O)N[C@@H](Cc2ccc(OCCN)cc2)C (=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 [{d}iso-Glu](1c)^(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu]K(1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 108 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCCCN C(=O)[C@H]2CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC C(N)=O)C(=O)N[C@@H](CCC(=O)N2)C(=O)N[C@@H](Cc2ccc(OCCN)cc2) C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 [{d}iso-Glu](1c)^(6c)^WQE(6c)[Y(2-aminoethoxy)][2-Nal][2-Me- Leu][Dab](1c)[Dab][3-(3-Pyridyl)-Ala]-[NHMe] 109 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCNC(= O)[C@H]2CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCC(N )=O)C(=O)N[C@@H](CCC(=O)N2)C(=O)N[C@@H](Cc2ccc(OCCN)cc2)C(= O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)W[2-Nal][2-Me-Leu]E(1c)[Dab][3-(3- Pyridyl)-Ala]-[NHMe] 110 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2c[nH]c3cccc c23)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N 1 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]W[Q(Me)]E(6c)[Y(2- aminoethoxy)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]- [NHMe] 111 CNC(=O)CC[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CCNC(=O )[C@@H]2CCCCNC(=O)CC[C@@H](C(=O)N[C@@H](CCN)C(=O)N[C@@ H](Cc3cccnc3)C(=O)NC)NC(=O)C(C)(C)NC(=O)[C@H](Cc3ccc4ccccc4c3)N C(=O)[C@H](Cc3ccc(OCCN)cc3)NC(=O)[C@H](CCC(=O)N2C)NC1=OCompound Structure K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4-morpholine)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]-[NHMe] CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) 112 NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc(N3CCO CC3)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C( =O)N1 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]W[2,4-Diaminobutanoyl(Ac-N- Me)]E(6c)[Y(2-aminoethoxy)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3- Pyridyl)-Ala]-[NHMe] 113 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@H]2C(=O)NCCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C @@H](CCN(C)C(C)=O)C(=O)N[C@@H](CCC(=O)N2C)C(=O)N[C@@H](Cc 2ccc(OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)(C)C(=O)N 1 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]W[2,4-Diaminobutanoyl(Ac)]E(6c)[Y(2- aminoethoxy)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]- [NHMe] 114 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@H]2C(=O)NCCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C @@H](CCNC(C)=O)C(=O)N[C@@H](CCC(=O)N2C)C(=O)N[C@@H](Cc2cc c(OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)(C)C(=O)N1 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2- aminoethoxy)][2Nal]{d}AE(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]- [NHMe] 115 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@H]2C(=O)NCCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C @@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)N2C)C(=O)N[C@@H](Cc2ccc (OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](C)C(=O)N1 {d}K(1c)(6c)^[3-Aminopropanoyl]WQ{d}E(6c)[Y(2-aminoethoxy)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]-[NHMe] 116 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@H]2NC(=O)CC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc(OCCN)c c2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4-THP)][2Nal][2-Me-Leu]E(1c)[2,4- Diaminobutanoyl][3-(3-Pyridyl)-Ala]-[NHMe] CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) 117 NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc(C3CCO CC3)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C( =O)N1Compound Structure N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2- aminoethoxy)][2Nal][Aib]E(1c)[Ser(OCH3)][3-(3-Pyridyl)-Ala]-[NHMe] 118 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](COC)NC(=O)[C@@H]1CCC(=O )NCCCC[C@H]2C(=O)NCCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C @@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)N2C)C(=O)N[C@@H](Cc2ccc (OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)(C)C(=O)N1 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(CH3-2-F)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]-[NHMe] 119 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc(OC)cc2 F)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]W[2,4-Diaminobutanoyl(Ac)]E(6c)[Y(2- aminoethoxy)][2Nal][Aib]E(1c)[Ser(OCH3)][3-(3-Pyridyl)-Ala]-[NHMe] 120 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](COC)NC(=O)[C@@H]1CCC(=O )NCCCC[C@H]2C(=O)NCCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C @@H](CCNC(C)=O)C(=O)N[C@@H](CCC(=O)N2C)C(=O)N[C@@H](Cc2cc c(OCCN)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)(C)C(=O)N1 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4-F)][2Nal][Aib]E(1c)[2,4- Diaminobutanoyl][3-(3-Pyridyl)-Ala]-[NHMe] 121 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@H]2C(=O)NCCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C @@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)N2C)C(=O)N[C@@H](Cc2ccc (F)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)(C)C(=O)N1 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4-piperazine)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]-[NHMe] CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) 122 NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc(N3CCN CC3)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C( =O)N1 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4-imidazole)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]-[NHMe] CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) 123 NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc(- n3ccnc3)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C )C(=O)N1Compound Structure K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(CH3-3-F)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]-[NHMe] 124 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc(OC)c(F) c2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2- aminoethoxy)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl]-[NH-2-(pyridin-3-yl)ethyl] 125 CC1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(OCCN)cc2) NC(=O)[C@@H]2CCC(=O)N[C@@H](CCCCNC(=O)CC[C@@H](C(=O)N[C @@H](CCN)C(=O)NCCc3cccnc3)NC1=O)C(=O)NCCC(=O)N[C@@H](Cc1c[ nH]c3ccccc13)C(=O)N[C@@H](CCC(N)=O)C(=O)N2 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4-piperidine)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]-[NHMe] CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) 126 NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc(C3CCN CC3)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C( =O)N1 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[5- AzaTrp][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]-[NHMe] 127 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@H]2C(=O)NCCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C @@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)N2C)C(=O)N[C@@H](Cc2c[n H]c3ccncc23)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)(C)C(=O)N1 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(Ac-2-aminoethoxy)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]-[NHMe] CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) 128 NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc(OC- CNC(C)=O)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C )C)C(=O)N1 K(1c)(6c)^[N-Me-3-Aminopropanoyl]WQE(6c)[Y(2- aminoethoxy)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]- [NHMe] 129 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCN(C)C2=O)C(=O)N[C@@H](Cc2ccc(OCC N)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)(C)C(=O)N1Compound Structure N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[7- AzaTrp][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]-[NHMe] 130 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@H]2C(=O)NCCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C @@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)N2C)C(=O)N[C@@H](Cc2c[n H]c3ncccc23)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)(C)C(=O)N1 N-Me-Lys](1c)(6c)^[3-Aminopropanoyl]WQE(6c)[6- AzaTrp][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]-[NHMe] 131 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@H]2C(=O)NCCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C @@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)N2C)C(=O)N[C@@H](Cc2c[n H]c3cnccc23)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)(C)C(=O)N1 N-Me-Lys-oxy-propanoyl(1c)(6c)^WQE(6c)[7- AzaTrp][2Nal][Aib]E(1c)[Ser(OCH3)][3-(3-Pyridyl)-Ala]-[NHMe] 132 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](COC)NC(=O)[C@@H]1CCC(=O )NCCCC[C@H]2C(=O)OCCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C @@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)N2C)C(=O)N[C@@H](Cc2c[n H]c3ncccc23)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)(C)C(=O)N1 N-Me-Lys](1c)(6c)^[3-Aminopropanoyl]W[2,4- Diaminobutanoyl(Ac)]E(6c)[Y(CH3)][2Nal][Aib]E(1c)[Ser(OCH3)][3-(3- Pyridyl)-Ala]-[NHMe] 133 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](COC)NC(=O)[C@@H]1CCC(=O )NCCCC[C@H]2C(=O)NCCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C @@H](CCNC(C)=O)C(=O)N[C@@H](CCC(=O)N2C)C(=O)N[C@@H](Cc2cc c(OC)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)(C)C(=O)N1 K(1c)(6c^[3-Aminopropanoyl]WQE(6c)[F(4-F)][2Nal][2-Me-Leu]E(1c)[2,4- Diaminobutanoyl][3-(3-Pyridyl)-Ala]-[NHMe] 134 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc(F)cc2)C (=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O)N1 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4- CONH2)][2Nal][Aib]E(1c)[Ser(OCH3)][3-(3-Pyridyl)-Ala]-[NHMe] 135 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](COC)NC(=O)[C@@H]1CCC(=O )NCCCC[C@H]2C(=O)NCCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C @@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)N2C)C(=O)N[C@@H](Cc2ccc (C(N)=O)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)(C)C(=O)N1Compound Structure K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2- aminoethoxy)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala][3- Aminopropanoyl]-[NH2] 136 CC1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(OCCN)cc2) NC(=O)[C@@H]2CCC(=O)N[C@@H](CCCCNC(=O)CC[C@@H](C(=O)N[C @@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(=O)NCCC(N)=O)NC1=O)C(=O) NCCC(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCC(N)=O)C(= O)N2 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2- aminoethoxy)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]{d}H- [NH2] 137 CC1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(OCCN)cc2) NC(=O)[C@@H]2CCC(=O)N[C@@H](CCCCNC(=O)CC[C@@H](C(=O)N[C @@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(=O)N[C@H](Cc3cnc[nH]3)C(N) =O)NC1=O)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@ H](CCC(N)=O)C(=O)N2 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(2- aminoethoxy)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]{d}W- [NH2] 138 CC1(C)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(OCCN)cc2) NC(=O)[C@@H]2CCC(=O)N[C@@H](CCCCNC(=O)CC[C@@H](C(=O)N[C @@H](CCN)C(=O)N[C@@H](Cc3cccnc3)C(=O)N[C@H](Cc3c[nH]c4ccccc3 4)C(N)=O)NC1=O)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[ C@@H](CCC(N)=O)C(=O)N2 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[Y(CF3)][2Nal][2-Me-Leu]E(1c)[2,4- Diaminobutanoyl][3-(3-Pyridyl)-Ala]-[NHMe] CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) 139 NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc(OC(F)(F )F)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O )N1 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[7- AzaTrp][2Nal][Aib]E(1c)[Ser(OCH3)][3-(3-Pyridyl)-Ala]-[NHMe] 140 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](COC)NC(=O)[C@@H]1CCC(=O )NCCCC[C@H]2C(=O)NCCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C @@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)N2C)C(=O)N[C@@H](Cc2c[n H]c3ncccc23)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)(C)C(=O)N1 K(1c)(6c)^[3-Aminopropanoyl]WQ{d}E(6c)[Y(2-aminoethoxy)][2Nal][2-Me- Leu]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-Ala]-[NHMe] CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) 141 NCCCC[C@@H]2NC(=O)CC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C @H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc(OCC N)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C(=O) N1Compound Structure N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]W[Q(2Me)]E(6c)[7- AzaTrp][2Nal][Aib]E(1c)[Ser(OCH3)][3-(3-Pyridyl)-Ala]-[NHMe] CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](COC)NC(=O)[C@@H]1CCC(=O 142 )NCCCC[C@H]2C(=O)NCCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C @@H](CCC(=O)N(C)C)C(=O)N[C@@H](CCC(=O)N2C)C(=O)N[C@@H](Cc 2c[nH]c3ncccc23)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)(C)C(=O) N1 N-Me-Lys(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4- morpholine)][2Nal][Aib]E(1c)[Ser(OCH3)][3-(3-Pyridyl)-Ala]-[NHMe] CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](COC)NC(=O)[C@@H]1CCC(=O 143 )NCCCC[C@H]2C(=O)NCCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C @@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)N2C)C(=O)N[C@@H](Cc2ccc (N3CCOCC3)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)(C)C(=O) N1 K(1c)(6c)^[3-Aminopropanoyl]WQE(6c)[F(4-morpholine)][2Nal][2-Me- Leu]E(1c)[Ser(OCH3)][3-(3-Pyridyl)-Ala]-[NHMe] CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](COC)NC(=O)[C@@H]1CCC(=O 144 )NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@ H](Cc3c[nH]c4ccccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc(N3CCO CC3)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@](C)(CC(C)C)C( =O)N1 K(1c)(6c)^[3-Aminopropanoyl][7-Me-Trp][Q(2Me)]E(6c)[Y(2- aminoethoxy)(N(Me)2)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)- alanyl]-[NHMe] 145 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(=O)N(C)C)NC(=O) [C@H](Cc3c[nH]c4c(C)cccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc( OCCN(C)C)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)(C)C(=O)N 1 K(1c)(6c)^[3-Aminopropanoyl][7MeTrp][Q(2Me)]E(6c)[Y(nPentylamine) (N+(Me)3)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-alanyl]-[NHMe] CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) 146 NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(=O)N(C)C)NC(=O) [C@H](Cc3c[nH]c4c(C)cccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc( OCCCCC[N+](C)(C)C)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)( C)C(=O)N1 K(1c)(6c)^[3-Aminopropanoyl][7-Me-Trp][Q(2Me)]E(6c)[Yr(2-trimethyl- PEG2)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)-alanyl]-[NHMe] CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) 147 NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCC(=O)N(C)C)NC(=O) [C@H](Cc3c[nH]c4c(C)cccc34)NC(=O)CCNC2=O)C(=O)N[C@@H](Cc2ccc( OCCOC- COCC[N+](C)(C)C)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NC(C)(C)C (=O)N1Compound Structure K(1c)(6c)^[3-Aminopropanoyl][7-Me-Trp][K(NMePEG3)]E(6c)[Y(2- aminoethoxy)(N(Me)2)][2Nal][Aib]E(1c)[2,4-Diaminobutanoyl][3-(3-Pyridyl)- alanyl]-[NHMe] 148 CNC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](CCN)NC(=O)[C@@H]1CCC(=O) NCCCC[C@@H]2NC(=O)CC[C@H](NC(=O)[C@H](CCCCN(C)C(=O)COC- COCC[N+](C)(C)C)NC(=O)[C@H](Cc3c[nH]c4c(C)cccc34)NC(=O)CCNC2=O )C(=O)N[C@@H](Cc2ccc(OCCN(C)C)cc2)C(=O)N[C@@H](Cc2ccc3ccccc3c 2)C(=O)NC(C)(C)C(=O)N1 or a pharmaceutically acceptable salt or solvate thereof; wherein:^denotes that the (1c), (6c), (6g), and (7c) bridges use the alpha-amine group (or beta- amine group for bLys, {d}bLys and beta-hLys, or the alpha-amine converted into an azide group for (N3)-K and {d}(N3)-K) of the amino acid in the bridge^denotes that the (1c), (6c), (6g), and (7c) bridges use the alpha-carboxylic acid group of the amino acid in the bridge (1c) denotes the [2,11] lactam bridge; (6c) denotes the [2,7] lactam bridge; (6g) denotes the [2,7] 1,4-disubstituted 1,2,3-triazole bridge; (7c) denotes the [10,13] lactam bridge.

24. A pharmaceutical composition comprising a compound according to any one of the preceding claims in combination with a pharmaceutically acceptable carrier, excipient or vehicle.

25. The pharmaceutical composition according to claim 24, wherein said pharmaceutical composition is for oral administration.

26. A method for the synthesis of a compound according to any one of claims 1 to 23, comprising synthesising the analogue by solid-phase or liquid-phase peptide synthesis methodology, optionally isolating and / or purifying the final product, and optionally further comprising the step of forming an amide bond between the amino acid residues at positions X2 and X11, and optionally further comprising the step of forming an amide bondor forming a triazole between the amino acid residues at positions X2 and X7, and optionally further comprising the step of forming an amide bond between the amino acid residues at positions X10 and X13.

27. A compound according to any one of claims 1 to 23, or a pharmaceutical composition according to any of claims 24-25, for use in a method of medical treatment.

28. A compound according to any one of claims 1 to 23, or a pharmaceutical composition according to any of claims 24-25, for use in a method of prevention or treatment of a disease or condition selected from inflammatory bowel disease (IBD), psoriasis, psoriatic arthritis, and combinations thereof.

29. The compound or pharmaceutical composition for use according to claim 28, wherein the IBD is selected from Crohn^s Disease or ulcerative colitis.