Tumor electric field therapy system

Abstract

The invention provides a tumor electric field treatment system which comprises an electrode plate and a controller, the electrode plate comprises a plurality of electrode units and a handshake chip, and each electrode unit comprises a dielectric element and a temperature sensor with a signal end and a grounding end. The plurality of electrode units are arranged in at least two rows and two columns on the circuit, the grounding ends of the temperature sensors in the same row are in short circuit through the same path of grounding wire, and the signal ends of the temperature sensors in the same column group are in short circuit through the same path of dual-purpose signal wire. The dual-purpose signal line is configured to transmit an alternating current signal to the corresponding dielectric element in a first mode, and transmit a direct current signal or a temperature signal detected by the corresponding temperature sensor to the signal end of the corresponding temperature sensor in a second mode. The controller is configured to communicate with the handshake chip so as to judge the connection state of the electrode slices, and is configured to combine and control the states of the grounding wire and the dual-purpose signal line when the electrode slices are normally connected so as to enable the dual-purpose signal line to be switched between transmission of an alternating current electric signal and transmission of a temperature detection signal.

Description

(19) State Intellectual Property Office (12) Invention Patent Application (10) Application Publication Number (43) Application Publication Date (21) Application Number 202511460926.3 (22) Application Date 2024.10.25 (66) Domestic Priority Data 202311809226.1 2023.12.26 CN PCT / CN2023 / 142515 2023.12.27 CN (62) Divisional Application Data 202411499210.X 2024.10.25 (71) Applicant Jiangsu Hailai Xinchuang Medical Technology Co., Ltd. Address 214100, Jiangsu Province, Wuxi City, Huishan Economic Development Zone, Huishan Avenue, No. 1699, Building 7, 7th Floor, Area A and Area B Applicant: Hangzhou Hailai Xinchuang Medical Technology Co., Ltd. (72) Inventors: Ying Jianjun, Yu Jing, Shen Qichao, Hui Jiajie, Zhang Jun Request: Name not to be disclosed Hu Tao (51) Int.Cl. A61N 1 / 36 (2006.01) A61N 1 / 04 (2006.01) G01K 13 / 00 (2021.01) (54) Invention Title: Tumor Electric Field Therapy System (57) Abstract: This application provides a tumor electric field therapy system, including an electrode sheet and a controller. The electrode sheet includes multiple electrode units and a handshake chip. The electrode unit includes a dielectric element and a temperature sensor with a signal terminal and a ground terminal. The electrode units are arranged in at least two rows and two columns in the circuit. The ground terminals of the temperature sensors in the same row are shorted through the same grounding line. The signal terminals of the temperature sensors in the same column are shorted through the same dual-purpose signal line. The dual-purpose signal line is configured to transmit an AC signal to the corresponding dielectric element in a first mode and transmit a DC signal to the signal terminal of the corresponding temperature sensor or transmit the temperature signal detected by the corresponding temperature sensor in a second mode. The controller is configured to communicate with a handshake chip to determine the connection status of the electrode pads, and is configured to combine the status of the control grounding line and the dual-purpose signal line when the electrode pads are normally connected, so that the dual-purpose signal line switches between transmitting AC signals and transmitting temperature detection signals. Claims 2 pages, Description 34 pages, Drawings 13 pages, CN 121360334 A 2026.01.20 CN 1 21 36 03 34 A 1. A tumor electric field therapy system, characterized in that it comprises: an electrode pad, the electrode pad including a flexible circuit board and a plurality of electrode units and a handshake chip disposed on the flexible circuit board, the electrode unit including a dielectric element and a temperature sensor having a signal terminal and a ground terminal, the flexible circuit board having multiple grounding lines connected to each of the ground terminals and multiple dual-purpose signal lines connected to each of the signal terminals, and the dielectric element being short-circuited to the signal terminal of the temperature sensor, the plurality of electrode units being arranged in at least two rows in the circuit.The temperature sensors in the same row group are short-circuited via the same grounding line, while the grounding terminals of temperature sensors in different row groups are connected in parallel via different grounding lines. The signal terminals of temperature sensors in the same column group are short-circuited via the same dual-purpose signal line, while the signal terminals of temperature sensors in different column groups are connected in parallel via different dual-purpose signal lines. Each dual-purpose signal line is configured to transmit an AC signal to the dielectric element of the corresponding electrode unit in a first mode, and to transmit a DC signal or the temperature signal detected by the temperature sensor of the corresponding electrode unit in a second mode. A controller is configured to communicate with the handshake chip to determine the connection status of the electrode sheet, and to combine the control of the grounding line and the dual-purpose signal line of the electrode sheet when the electrode sheet is normally connected, so that the dual-purpose signal line switches between transmitting AC signals and transmitting temperature detection signals. 2. The tumor electric field therapy system according to claim 1, wherein the controller is configured to: send a handshake signal to the handshake chip and determine whether the electrode pads are properly connected based on whether feedback from the handshake chip is received. 3. The tumor electric field therapy system according to claim 1, wherein the controller is further configured to: control or adjust the AC signal transmitted to the dual-purpose signal line based on the detected temperature detection signals of each of the electrode units. 4. The tumor electric field therapy system according to claim 1, wherein the controller is further configured to: determine the operating state of each of the electrode units based on the detected temperature detection signals of each of the electrode units, the operating state including continuing to apply the AC signal and stopping applying the AC signal. 5. The tumor electric field therapy system according to any one of claims 1-4, wherein the system has a preset temperature threshold. 6. The tumor electric field therapy system according to claim 5, wherein the controller is further configured to: compare the obtained temperature detection signals of each of the electrode units with the preset temperature threshold; and control or adjust the AC signal transmitted to the dual-purpose signal line based on the comparison result. 7. The tumor electric field therapy system according to claim 6, wherein the controller is configured to: continue applying an AC signal to each electrode unit of the electrode sheet when none of the acquired temperature detection signals of each electrode unit of the electrode sheet exceed a preset temperature threshold; or stop applying an AC signal to the electrode unit of the electrode sheet when any one of the acquired temperature detection signals of each electrode unit of the electrode sheet exceeds a preset temperature threshold. 8. The tumor electric field therapy system according to claim 6, wherein the comparison result includes not exceeding a preset temperature threshold.A temperature threshold and a preset temperature threshold are defined. The condition of not exceeding the preset temperature threshold includes being significantly lower than the preset temperature threshold and being close to the preset temperature threshold. When the temperature detection signal of each electrode unit does not exceed the preset temperature threshold, the controller is further configured to continue transmitting AC signals to the dual-purpose signal line in the following manner: When the temperature detection signal is significantly lower than the preset temperature threshold, the AC signal is continued to be transmitted to the dual-purpose signal line by increasing the voltage, current, or power amplitude of the AC signal currently transmitted to the dual-purpose signal line, or by maintaining the voltage, current, or power amplitude of the AC signal currently transmitted to the dual-purpose signal line unchanged; or when the temperature detection signal is close to the preset temperature threshold, the AC signal is continued to be transmitted to the dual-purpose signal line by maintaining the voltage, current, or power amplitude of the AC signal currently transmitted to the dual-purpose signal line unchanged, or by decreasing the voltage, current, or power amplitude of the AC signal currently transmitted to the dual-purpose signal line. 9. The tumor electric field therapy system according to claim 1, wherein the controller is further configured to: determine the type of the electrode sheet based on the temperature detection signal of each of the electrode units; or determine whether the electrode sheet has a temperature abnormality based on the temperature detection signal of each of the electrode units; or determine whether the temperature sensor of the electrode sheet has malfunctioned based on the temperature detection signal of each of the electrode units; or determine whether the electrode unit of the electrode sheet has overheated based on the temperature detection signal of each of the electrode units. 10. The tumor electric field therapy system according to claim 9, wherein the controller is further configured to: determine whether the electrode sheet needs to be replaced based on the malfunction of the temperature sensor of the electrode sheet. Claims 2 / 2 Page 3 CN 121360334 A Tumor Electric Field Therapy System

[0001] This application is a divisional application filed by the applicant on October 25, 2024, with application number CN202411499210.X and invention title "Electrode Sheet, Tumor Electric Field Therapy System and Temperature Detection and Signal Control Method". Technical Field

[0002] This application relates to tumor treating field (TTF) technology, and more particularly to a tumor treating field system. Background Art

[0003] Tumor treating field therapy is a method of treating tumors by using a low-intensity, medium-to-high frequency alternating electric field to prevent the formation of spindle microtubules during mitosis of certain tumor cells, inhibit the separation of intracellular organelles during cell division, and induce apoptosis during mitosis.

[0004] Compared with traditional cancer treatments, TTF has an innovative mechanism of action. Some physiological characteristics of tumor cells, such as their geometry and high-frequency mitosis, make them susceptible to TTF. TTF disrupts the normal aggregation of tubulin by applying directional forces to polar particles (such as macromolecules and organelles) within the cell. These processes can lead to physical damage to the cell membrane and apoptosis. During the telophase of mitosis, the morphology of the cleavage groove leads to an uneven distribution of the electric field around it. Simultaneously, under the influence of TTF, the electric field strength at the cleavage groove is significantly enhanced, causing charged substances in the cell to move towards the cleavage groove, interfering with or even destroying the formation of cell structures, ultimately leading to cell division failure and apoptosis.

[0005] In existing tumor electric field therapy systems, an electric field generator transmits an alternating current signal for tumor electric field therapy to an electrode pad, which then applies an alternating electric field to the patient's tumor site for tumor electric field therapy. When the tumor treatment electric field is applied to the patient's body, heat accumulates at the application site, and the temperature rises accordingly. Therefore, it is necessary to monitor the temperature at the application site. When the temperature is too high, the electric field strength needs to be adjusted in time to avoid the risk of burns to the patient's skin due to excessive temperature.

[0006] The tumor electric field therapy system includes at least one pair of electrode pads, each of which contains multiple electrode units. Even if the same AC signal is applied to each electrode unit, the heat generated on each electrode unit will vary depending on its location. That is, the temperature of each electrode unit on the entire electrode pad will not be completely uniform. This may result in some electrode units on the entire electrode pad having a temperature exceeding the preset temperature, while the temperature of other electrode units is normal. In order to ensure that the tumor electric field therapy has a sufficiently long application time while avoiding low-temperature burns to the patient's skin, it is necessary to individually control the overheated electrode units. However, for existing electrode pads, individual control of electrode units requires setting a conductive trace for each electrode unit in the substrate of the electrode pad. This will increase the number of conductive traces in the substrate of the electrode pad, making the electrode pad difficult to bend. In addition, the cables electrically connected to the electrode pad will be thickened, increasing the overall weight of the electrode pad, which is not conducive to the application of the electrode pad.

[0007] Therefore, it is necessary to provide an improved tumor electric field therapy system. Summary of the Invention

[0008] The purpose of this application is to provide a tumor electric field therapy system with an electrode sheet having a handshake chip.

[0009] To achieve the above objective, this application provides the following technical solution: a tumor electric field therapy system, comprising: an electrode sheet, the electrode sheet including a flexible circuit board and a plurality of electrode units and a handshake chip disposed on the flexible circuit board, [Specification 1 / 34 page 4 CN 121360334 A] The electrode unit includes a dielectric element and a temperature sensor having a signal terminal and a ground terminal, the flexible circuit board having a connecting...The circuit includes multiple grounding lines connected to each of the aforementioned grounding terminals and multiple dual-purpose signal lines connected to each of the aforementioned signal terminals. The dielectric element is short-circuited to the signal terminal of the temperature sensor. The electrode units are arranged in at least two rows and two columns on the circuit. The grounding terminals of the temperature sensors located in the same row group are short-circuited through the same grounding wire, and the grounding terminals of the temperature sensors located in different row groups are connected in parallel through different grounding wires. The signal terminals of the temperature sensors located in the same column group are short-circuited through the same dual-purpose signal line, and the signal terminals of the temperature sensors located in different column groups are connected in parallel through different dual-purpose signal lines. Each dual-purpose signal line is configured to transmit an AC signal to the dielectric element of each electrode unit in the corresponding column group in a first mode, and to transmit a DC signal or the temperature signal detected by the temperature sensor of each electrode unit in the corresponding column group in a second mode. A controller is configured to communicate with the handshake chip to determine the connection status of the electrode sheet, and is configured to combine and control the state of the grounding wire and the dual-purpose signal line of the electrode sheet when the electrode sheet is normally connected so that the dual-purpose signal line switches between transmitting AC signals and transmitting temperature detection signals.

[0010] Further, the controller is configured to: send a handshake signal to the handshake chip and determine whether the electrode is properly connected based on whether feedback from the handshake chip is received.

[0011] Further, the controller is also configured to: control or adjust the AC signal transmitted to the dual-purpose signal line based on the temperature detection signals of each of the electrode units.

[0012] Further, the controller is also configured to: determine the working state of each of the electrode units based on the temperature detection signals of each of the electrode units, the working state including continuing to apply the AC signal and stopping applying the AC signal.

[0013] Further, the system has a preset temperature threshold.

[0014] Further, the controller is also configured to: compare the obtained temperature detection signals of each of the electrode units with the preset temperature threshold; and control or adjust the AC signal transmitted to the dual-purpose signal line based on the comparison result.

[0015] Further, the controller is configured to: continue applying AC signals to each electrode unit of the electrode sheet when none of the acquired temperature detection signals of each electrode unit of the electrode sheet exceed a preset temperature threshold; or stop applying AC signals to the electrode unit of the electrode sheet when one of the acquired temperature detection signals of each electrode unit exceeds a preset temperature threshold.

[0016] Further, the comparison result includes "not exceeding the preset temperature threshold" and "exceeding the preset temperature threshold," wherein "not exceeding the preset temperature threshold"...Exceeding the preset temperature threshold includes being far below the preset temperature threshold and being close to the preset temperature threshold. When the temperature detection signals of each of the electrode units do not exceed the preset temperature threshold, the controller is further configured to continue transmitting AC signals to the dual-purpose signal line in the following manner: when the temperature detection signal is far below the preset temperature threshold, continue transmitting AC signals to the dual-purpose signal line by increasing the voltage, current, or power amplitude of the AC signal currently transmitted to the dual-purpose signal line, or continue transmitting AC signals to the dual-purpose signal line by keeping the voltage, current, or power amplitude of the AC signal currently transmitted to the dual-purpose signal line unchanged; or when the temperature detection signal is close to the preset temperature threshold, continue transmitting AC signals to the dual-purpose signal line by keeping the voltage, current, or power amplitude of the AC signal currently transmitted to the dual-purpose signal line unchanged, or continue transmitting AC signals to the dual-purpose signal line by decreasing the voltage, current, or power amplitude of the AC signal currently transmitted to the dual-purpose signal line.

[0017] Further, the controller is also configured to: determine the type of the electrode sheet based on the temperature detection signal of each electrode unit; or determine whether the electrode sheet has a temperature abnormality based on the temperature detection signal of each electrode unit; or determine whether the temperature sensor of the electrode sheet has malfunctioned based on the temperature detection signal of each electrode unit; or determine whether the electrode unit of the electrode sheet has overheated based on the temperature detection signal of each electrode unit.

[0018] Further, the controller is also configured to: determine whether the electrode sheet needs to be replaced based on the malfunction of the temperature sensor of the electrode sheet.

[0019] The above description is only an overview of the technical solution of this application. In order to better understand the technical means of this application and to implement it according to the content of the specification, and to make the above and other objects, features and advantages of this application more obvious and understandable, specific embodiments of this application are given below.

[0020] FIG1 is a schematic diagram of a tumor electric field therapy system according to an embodiment of the present application, showing a spatial structure diagram of the electrode sheet of the first embodiment;

[0021] FIG2 is a schematic diagram of the structural layout of a modified embodiment of the electrode sheet of the first embodiment of the tumor electric field therapy system shown in FIG1 of the present application;

[0022] FIG3 is a schematic diagram of the circuit connection of the tumor electric field system shown in FIG1 of the present application, showing a circuit connection diagram of the electrode sheet of the first embodiment shown in FIG1 or the electrode sheet of the modified embodiment shown in FIG2 with the adapter shown in FIG1 of the first embodiment;

[0023] FIG4 is a schematic block diagram of the internal structure of the adapter shown in FIG3 of the present application;

[0024] FIG5 is a schematic block diagram of the internal structure of the electric field generator of the tumor electric field therapy system shown in FIG1 of the present application;

[0025] Figure 6, similar to Figure 3, is a circuit connection diagram of the tumor electric field therapy system according to the second embodiment of this application, showing the circuit connection diagram between the electrode sheet of the second embodiment of the tumor electric field therapy system and the adapter shown in Figure 3;

[0026] Figure 7, similar to Figure 3, is a circuit connection diagram of the tumor electric field therapy system according to the third embodiment of this application, showing the circuit connection diagram between the electrode sheet of the third embodiment of the tumor electric field therapy system and the adapter shown in Figure 3;

[0027] Figure 8, similar to Figure 3, is a circuit connection diagram of the tumor electric field therapy system according to the fourth embodiment of this application, showing the circuit connection diagram between the electrode sheet of the fourth embodiment of the tumor electric field therapy system and the adapter shown in Figure 3;

[0028] Figure 9, similar to Figure 3, is a circuit connection diagram of the tumor electric field therapy system according to the fifth embodiment of this application, showing the circuit connection diagram between the electrode sheet of the fifth embodiment of the tumor electric field therapy system and the adapter shown in Figure 3;

[0029] Figure 10 is a flowchart of a temperature detection method for the tumor electric field therapy system of this application;

[0030] Figure 11 is a flowchart of the tumor electric field therapy system of this application;

[0031] Figure 12 is another flowchart of the temperature detection method of the tumor electric field therapy system of this application;

[0032] Figure 13 is a flowchart of the AC signal application control method for tumor electric field therapy of this application;

[0033] Figure 14 is a flowchart of the signal control method for tumor electric field therapy of this application;

[0034] Figure 15 is a flowchart of the electrode temperature detection method of this application;

[0035] Figure 16 is a flowchart of the AC signal application method for tumor electric field therapy of this application.

[0036] Explanation of reference numerals: Specification 3 / 34 pages 6 CN 121360334 A

[0037] Tumor electric field therapy system 100, electrode sheets 10, 10', 10D, 10E, 10F, 10H, flexible circuit boards 11, 11D, 11E, 11F, 11H, Connecting parts 111, 111', Wiring parts 112, 112', Bridging parts 113, 113', Main trunk 114, 114', Branch 115, 115', First interval D1, D1', Second interval D2, D2', Electrode unit 12, 12', First cable 13, 13', Temperature sensor 14, Grounding terminal 14-1, Signal terminal 14-2, Dielectric element 15, Diode 16, Handshake chip 17, Grounding trace 171, Communication line 172, Grounding wire 18, First grounding wire 18-1, Second grounding wire 18-2, Third grounding wire 18-3, Fourth grounding wire 18-4, Dual-purpose signal line 19, First dual-purpose signal line 19-1, Second dual-purpose signal line 19-2, Third dual-purpose signal line 19-3, Fourth dual-purpose signal lineLine 19-4, Fifth Dual-Purpose Signal Line 19-5, Adapter 20, Second Cable 21, First Controller 22, Analog-to-Digital Converter 23, Voltage Divider Resistor 24, Grounding Switch 25, First Grounding Switch 25-1, Second Grounding Switch 25-2, Third Grounding Switch 25-3, Fourth Grounding Switch 25-4, Bidirectional Switch 26, First Bidirectional Switch 26-1, Second Bidirectional Switch 26-2, Third Bidirectional Switch 26-3, Fourth Bidirectional Switch 26-4, Fifth Bidirectional Switch 26-5, First Communication Unit 27, AC Signal Line 28, First Power Module 29, Communication Transmission Line 211, Electric Field Generator 30, Second Power Module 31, Second Controller 32, Second Communication Unit 33, AC Signal Generator 34, AC Signal Switch 35, First AC Signal Switch 35-1, First AC Signal Switch 35- 2. First AC signal switch 35-3, first AC signal switch 35-4, first connectors 40, 40D, 40E, 40F, 40H, first plugs 41, 41', first socket 42, second connector 50, second plug 51, second socket 52. Detailed Description

[0038] The embodiments of the technical solution of this application will be described in detail below with reference to the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solution of this application, and are therefore only examples, and cannot be used to limit the scope of protection of this application.

[0039] FIG1 is a schematic diagram of a tumor electric field therapy system 100 according to an embodiment of this application. As shown in FIG1, the tumor electric field therapy system 100 includes: at least one pair of electrode plates 10, an adapter 20 connected to the electrode plates 10, and an electric field generator 30 connected to the adapter 20. The electric field generator 30 generates an AC signal for tumor treatment and applies the AC signal to the electrode plates 10 through the adapter 20, so that a therapeutic electric field is generated between the paired electrode plates 10. The adapter 20 is electrically connected between the electrode pad 10 and the electric field generator 30, and is used to transmit the AC signal generated by the electric field generator 30 to the electrode pad 10. That is, the electric field generator 30 can generate an AC signal, which is transmitted to each electrode pad 10 through the adapter 20, creating a therapeutic electric field for tumor treatment between the same pair of electrode pads 10. As shown in Figure 1, in this embodiment, there are four electrode pads 10. From a spatial arrangement perspective, each electrode pad 10 includes multiple electrode units 12 arranged in both axially and centrally symmetrical positions, several connecting portions 111 located between adjacent electrode units 12, a bridging portion 113 spanning between adjacent connecting portions 111, a wiring portion 112 connected to the bridging portion 113, and a first cable 13 connected to the wiring portion 112. The bridging portion 113 and the wiring portion 112 are arranged perpendicularly, forming a "T" shape.113 is installed between two adjacent connecting parts 111. Each electrode unit 12 of the electrode pad 10 is electrically connected to the adapter 20 via a first cable 13 having 10 core wires.

[0040] Each electrode unit 12 has a temperature sensor 14 and a dielectric element 15. The temperature sensor 14 is used to detect the temperature of the part of the electrode unit 12 applied to the patient's body surface. It can be a thermistor element or a temperature sensor other than a thermistor, and can be set at any position on the electrode unit 12. The dielectric element 15 is used to apply an alternating current signal to the tumor site of the patient. The dielectric element 15 can be a dielectric ceramic sheet or a polymer dielectric layer made of polymer material. In this embodiment, each dielectric element 15 has a through hole (not labeled) in the middle for accommodating a corresponding temperature sensor 14. Each electrode unit 12 may also include a diode 16 connected in series with the temperature sensor 14, which can prevent reverse current flow to prevent detection signals from other electrode units 12 from affecting the temperature sensor 14. The ground terminal 14-1 of the temperature sensor 14 is connected in series with the anode of the diode 16 and grounded through the cathode of the diode 16.

[0041] In the first mode, the electrode unit 12 applies an alternating current signal through the dielectric element 15; in the second mode, the temperature of the patient's body surface to which the corresponding electrode unit 12 is applied is detected or acquired by the temperature sensor 14; in the third mode, the application of the alternating current signal is stopped and temperature detection and acquisition are stopped. The first mode, the second mode, and the third mode do not overlap in time period. That is, the time period during which the dielectric element 15 of the electrode unit 12 applies the alternating current signal is staggered and does not overlap with the time period during which the temperature sensor 14 detects the temperature. Electrode unit 12 can cycle between applying an AC signal through its dielectric element 15 and detecting temperature through its temperature sensor 14, that is, electrode unit 12 can cycle between a first mode and a second mode. Electrode unit 12 can also cycle between a first mode, a second mode, and a third mode, that is, electrode unit 12 can cycle between applying an AC signal through the dielectric element 15, collecting or detecting temperature through the temperature sensor 14, stopping applying the AC signal, and collecting temperature.

[0042] Each electrode sheet 10 includes an electrode array (unlabeled) consisting of 20 electrode units 12. The electrode array (unlabelled) also includes a flexible circuit board 11 comprising a connection portion 111, a wiring portion 112, and a bridging portion 113. The 20 electrode units 12 are spaced apart in the electrode array (unlabelled) arranged in four rows and six columns. Specifically, the first and last rows each have four electrode units 12, and the middle two rows each have six electrode units 12. The four electrode units 12 in the first row are respectively located at...In each of the second to fifth columns, the six electrode units 12 in the middle two rows are located in each of the first to sixth columns, and the four electrode units 12 in the last row are also located in each of the second to fifth columns. The connecting portion 111 is only located between adjacent electrode units 12 arranged in the column direction in the third and fourth columns, and between adjacent electrode units 12 in the row direction, except for the two electrode units 12 located in the third and fourth columns of each row. That is, adjacent electrode units 12 in the third and fourth columns are only connected by the connecting portion 111 in the column direction, and are disconnected and not connected by the connecting portion 111 in the row direction; the electrode units 12 in the first, second, fifth, and sixth columns are only connected to their adjacent electrode units 12 in the row direction by the horizontally arranged connecting portion 111, and are disconnected in the column direction and from their adjacent electrode units 12. That is, the two adjacent electrode units 12 in each of the first, second, fifth, and sixth columns are all disconnected.

[0043] The electrode unit 12 in the third column and the connecting portion 111 arranged longitudinally between the electrode units 12 in that column, as well as the electrode unit 12 in the fourth column and the connecting portion 111 arranged longitudinally between the electrode units 12 in that column, all constitute the main trunk 114 of the electrode array (unlabeled). The connecting portions 111 located on opposite sides of the electrode units 12 in the third and fourth columns and connected to each electrode unit 12 in the third and fourth columns respectively by the connecting portions 111 arranged laterally, and the electrode units 12 connected to the connecting portions 111 arranged laterally, all constitute the branches 115 of the electrode array (unlabeled). That is, in this embodiment, the electrode array (unlabeled) includes two main trunks 114 and several branches 115 that extend laterally from the two main trunks 114 respectively. Each branch 115 has a free end away from the main trunk 114. The free ends of adjacent branches 115 are disconnected, and the position and distance between adjacent branches 115 can be freely adjusted according to the actual usage scenario. Specifically, one main trunk 114 is composed of each electrode unit 12 located in the third column and a connecting part 111 located between adjacent electrode units 12 in the same column and arranged longitudinally. Another main trunk 114 is composed of each electrode unit 12 located in the fourth column and a connecting part 111 located between adjacent electrode units 12 in the same column and arranged longitudinally. The remaining electrode units 12 connected to the main trunk 114 by the horizontally arranged connecting parts 111 and the horizontally arranged connecting parts 111 are all branches 115.

[0044] Specifically, the branches 115 are: a connecting part 111 located in the first row of the third column and extending laterally to the left, and an electrode unit 12 located in the second column of the first row and connected to the connecting part 111;The electrode unit 12 in the second row of the third column extends laterally to the left and is located in the second row. Two connecting portions 111 are also located in the second row. (See page 5 / 34 of the specification, CN 121360334 A for the first and second columns of the second row.) Electrode unit 12; two connecting portions 111 extending laterally to the right from the electrode unit 12 in the second row of the fourth column and located in the second row, and two electrode units 12 located in the fifth and sixth columns of the second row; two connecting portions 111 extending laterally to the right from the electrode unit 12 in the third row of the fourth column and located in the third row, and two electrode units 12 located in the fifth and sixth columns of the third row; a connecting portion 111 extending laterally to the right from the electrode unit 12 in the fourth row and located in the fourth row, and an electrode unit 12 located in the fifth column of the fourth row.

[0045] The electrode array (unlabeled) is divided into a symmetrical left portion including three columns on the left and a right portion including three columns on the right, and the left and right portions are connected only by a bridging portion 113. The left side consists of a main stem 114 located in the third column and several branches 115 extending to the left from the main stem 114. The right side consists of a main stem 114 located in the fourth column and several branches 115 extending to the right from the main stem 115. The two main stems 114 are connected by a bridging portion 113. Specifically, the two main stems 114 are electrically connected by a bridging portion 113 between the connecting portions 111 of the electrode units 12 in the second row of the third column and the connecting portions 111 of the electrode units 12 in the second row of the fourth column and the connecting portions 111 of the electrode units 12 in the third row of the fourth column. The connecting portions 111 of the electrode units 12 in the second row of the third column and the connecting portions 111 of the electrode units 12 in the second row of the third column and the connecting portions 111 of the electrode units 12 in the second row of the fourth column and the connecting portions 113 are generally arranged in an "H" shape. In other embodiments, the bridging portion 113 may also be disposed between an electrode unit 112 located in the third column and an electrode unit 12 located in the fourth column. Optionally, the bridging portion 113 may be disposed between two electrode units 12 located in the third and fourth columns and adjacent in the row direction.

[0046] Each electrode unit 12 can be divided into peripheral electrode units 12 and central electrode units 12 according to its position in the electrode array (unlabeled). The peripheral electrode units 12 include four electrode units located in the first row.12. Two electrode units 12 located at opposite ends of the second row, two electrode units 12 located at opposite ends of the third row, and four electrode units 12 located in the fourth row. The electrode units 12 located in the center include four electrode units 12 located in the middle of the second row and four electrode units 12 located in the middle of the third row. Among the multiple electrode units 12 located on the periphery, some adjacent electrode units 12 are connected by a laterally arranged connecting portion 111, while some adjacent electrode units 12 are disconnected. Among the multiple electrode units 12 located on the periphery, the adjacent electrode units 12 connected by the connecting portion 111 are partially row-adjacent electrode units 12. Specifically, among the multiple electrode units 12 located on the periphery, the electrode units 12 that are adjacent in the column direction and diagonally adjacent are all disconnected; some row-adjacent electrode units 12 are also disconnected; only some row-adjacent electrode units 12 are connected by a laterally extending connecting portion 111. In the plurality of electrode units 12 located at the center, only two adjacent electrode units 12 in the column direction on the main trunk 114 are connected by a longitudinally arranged connecting part 111, and only two adjacent electrode units 12 in the row direction on the branch 115 are connected by a transversely arranged connecting part 111.

[0047] The electrode array (unlabeled) also has gaps (unlabeled) formed between a plurality of spaced electrode units 12, which allow moisture from the patient's skin to escape, heat exchange between the patient's skin and the outside world, or free breathing of the patient's skin, and also allow the positions and spacing between the branches 115 to be freely adjusted, and also prevent wrinkles when the electrode pads 10 are applied. The gaps (unlabeled) include a first gap D1 located between the two main trunks 114 and a second gap D2 located between the branches 115. The first gap D1 is located between the third column of electrode units 12 and the fourth column of electrode units 12, and the second gap D2 is located between the electrode units 12 in adjacent rows. That is, along the row upwards, the electrode unit 12 located in the third column is disconnected from the adjacent electrode unit 12 located in the fourth column, and no connecting part 111 is provided, but instead forms the aforementioned first interval D1; and along the column upwards, only the three columns and the four columns of the specification 6 / 34 9 CN 121360334 A have two adjacent electrode units 12 connected by the connecting part 111, while the two adjacent electrode units 12 in the other four columns are not connected by the connecting part 111, but instead form the aforementioned second interval D2. The setting of the first and second intervals D1 and D2 can also increase the degree of freedom of some electrode units 12, and can also avoid wrinkles when attaching the electrode sheet 10.

[0048] The electrode sheet 10 also includes a handshake chip 17 disposed on the flexible circuit board 11 and used to confirm its connection status. The handshake chip 17 can communicate with the electric field generator 30 through the adapter 20 to determine the connection status between the electrode sheet 10 and the adapter 20.The connection status of the tumor electric field therapy system 100 is determined by the electric field generator 30, which first sends a handshake communication signal to the handshake chip 17 of the electrode 10 through the adapter 20, and determines the connection status of the electrode 10 based on whether the handshake chip 17 has received feedback. After confirming that the electrode 10 is properly connected through the handshake chip 17, the electric field generator 30 of the tumor electric field therapy system 100 applies an AC signal to the dielectric element 15 of the electrode 10 or transmits a DC signal to each temperature sensor 14 of the electrode 10 to collect temperature detection signals. The handshake chip 17 can be an EEPROM with encryption function.

[0049] In some other embodiments, the tumor electric field therapy system 100 may have more or fewer electrode 10s. In some other embodiments, each pair of electrode 10s may have the same or different number of electrode units 12, and different pairs of electrode 10s may also have different numbers of electrode units 12. In some other embodiments, the 20 electrode units 12 may also be arranged in other ways. Of course, in some other embodiments, the electrode sheet 10 may also have other numbers of electrode units 12. In some other embodiments, the 20 electrode units 12 may also be arranged in other ways, as shown in the electrode sheet 10' of FIG2. Of course, in some other embodiments, the electrode sheet 10 may also have other numbers of electrode units 12. In summary, the implementation of this application is not limited by the number and arrangement of the electrode units 12 of the electrode sheet 10.

[0050] The electrode sheet 10' shown in FIG2 is a modified embodiment of the electrode sheet 10 shown in FIG1. ​​The spatial structure of the electrode sheet 10' is the same as that of the electrode sheet 10, and it also includes a plurality of electrode units 12' arranged at intervals, a plurality of connecting portions 111' located between two adjacent electrode units 12', a wiring portion 112' connected to the bridging portion 113', a first cable 13' connected to the wiring portion 112', a first interval D1 formed between the third column electrode units 12' and the fourth column electrode units 12', and a second interval D2' formed between the electrode units 12' in adjacent rows; the connecting portion 111', the wiring portion 112', and the bridging portion 113' also constitute a flexible circuit board (not labeled), and the electrode sheet 10' is also plugged into the adapter 20 through the first plug 41' of the first cable 13' with 10 core wires. The only difference is that the two adjacent electrode units 12' in the fourth column are arranged in a disconnected state. The electrodes are not connected by the vertically arranged connecting parts 111', but adjacent electrode units 12' in the fifth column are connected by the vertically arranged connecting parts 111'. Each electrode unit 12' in the fourth column is connected to the adjacent electrode unit 12' in the fifth column by the horizontally arranged connecting parts 111'. And the bridging part 113' connects to the electrode unit 12' in the third row.Between the three columns and the two electrode units 12' located in the third row and fourth column. One main branch 114' is composed of the electrode unit 12' located in the third column and the connecting part 111' located between the electrode units 12' in that column, and the other main branch 114' is composed of the electrode unit 12' located in the fifth column and the connecting part 111' located between the electrode units 12' in that column. The structure of the left side of the left three columns of the electrode array (unlabeled) is exactly the same as the structure of the left side of the electrode array (unlabeled) shown in FIG1. ​​Only the right side is different because the position of the main branch 114' changes from the fourth column to the fifth column, resulting in the branch 115' in the right side extending to the left and right sides of the corresponding electrode unit 12' in the main branch 114' respectively.

[0051] FIG3 is a schematic diagram of the circuit connection between the electrode sheet 10 of the first embodiment of the tumor electric field therapy system 100 shown in FIG1 or the electrode sheet 10' of the transformation embodiment shown in FIG2 and the adapter 20 of the first embodiment. It is worth noting that the arrangement of electrode units 12 shown in Figure 3 is to more clearly illustrate the electrical connection between an electrode sheet 10 and the adapter 20. The arrangement of electrode units 12 shown in Figure 3 does not represent the spatial arrangement of electrode units 12. The circuit connection is described below using the electrode sheet 10 in the first embodiment as an example.

[0052] Referring to Figures 1 and 3, in this embodiment, each electrode sheet 10 is provided with 20 electrode units 12. The 20 electrode units 12 are arranged in the order of 1 to 20 in the circuit connection and are divided into four row groups and five column groups, that is, the 20 electrode units 12 are arranged in four rows and five columns in the circuit connection. The temperature sensor 14 of each electrode unit 12 includes a ground terminal 14-1 and a signal terminal 14-2. The dielectric element 15 and temperature sensor 14 of each electrode unit 12 are soldered onto the flexible circuit board 11, and the dielectric element 15 is shorted to the signal terminal 14-2 of the corresponding temperature sensor 14. Since the electrode units 12 are arranged in a four-row, five-column configuration in the circuit connection, and each electrode unit includes a corresponding dielectric element 15 and a corresponding temperature sensor 14, the multiple temperature sensors 14 are also arranged in a four-row, five-column configuration in the circuit connection, and the multiple dielectric elements 15 are also arranged in a four-row, five-column configuration in the circuit connection. It should be noted that this arrangement is for clearer illustration of the electrical connection between the electrode sheet 10 and the adapter 20, and does not represent the spatial arrangement of the electrode units 12. The spatial structure may be a roughly array-like structure as shown in Figure 1, or other structures, such as petal-shaped or scattering structures, and can be regular or irregular. The dielectric element 15 is configured to apply an alternating electric field to the patient's tumor site. Temperature sensor 14 is configured to detect the temperature of the patient’s body surface that is in contact with electrode pad 10 and output a temperature detection signal to adapter 20.

[0053] The flexible circuit board 11 is embedded with multiple conductive traces 171, 172, 18, and 19. These traces include multiple grounding lines 18, multiple dual-purpose signal lines 19, one grounding trace 171, and one communication line 172. One end of the grounding trace 171 is connected to the grounding pin of the handshake chip 17, and the other end is connected to any one of the grounding lines 18. The grounding pin of the handshake chip 17 is connected to the grounding trace 171, and its communication pin is electrically connected to the communication line 172. That is, the handshake chip 17 is grounded through the grounding line 18 connected to the grounding trace 171 and communicates with external devices through the communication line 172. Specifically, the handshake chip 17 is grounded via a ground trace 171 connected to its ground pin and a ground line 18. It then sequentially connects to the communication line 172 of the flexible circuit board 11, a wire electrically connected to the first cable 13 and the communication line 172, an adapter 20 electrically connected to the first cable 13, and an electric field generator 30 electrically connected to the adapter 20, thereby determining the connection status of the electrode plate 10. The first cable 13 has multi-core wires (not shown) electrically connected to the communication line 172, the multiple ground lines 18, and the multiple dual-purpose signal lines 19 of the flexible circuit board 11, respectively. The total number of communication lines 172, ground lines 18, and dual-purpose signal lines 19 embedded in the flexible circuit board 11 does not exceed 10. Therefore, the number of wires in the first cable 13 does not exceed 11.

[0054] The number of conductive lines electrically connected to the grounding wire 18 in the tumor electric field therapy system 100 is related to the number of rows M of the electrode unit 12, which can be greater than or equal to the number of rows M of the electrode unit 12, where M is a positive integer. The number of conductive lines electrically connected to the dual-purpose signal line 19 in the tumor electric field therapy system 100 is related to the number of columns N of the electrode unit 12, which can be greater than or equal to the number of columns N of the electrode unit 12, where N is a positive integer. In this embodiment, the number of grounding wires 18 is equal to the number of rows M of the electrode unit 12; the number of columns N of the dual-purpose signal line 19 is equal to the number of columns N of the electrode unit 12. The number of lines L embedded in the flexible circuit board 11 is equal to the sum of the number of grounding wires 18 and the number of dual-purpose signal lines 19 plus 2, that is, L = M + N + 2. The number of conductors in the first cable 13 is M + N + 1.

[0055] The multi-purpose signal lines 19 of the flexible circuit board 11 are respectively arranged in a one-to-one correspondence with multiple columns of the electrode units 12. They are configured to transmit the AC signal generated by the electric field generator 30 to the dielectric element 15 in each electrode unit 12 in the corresponding column. That is, the dielectric elements 15 located in the same column are all short-circuited through the same multi-purpose signal line 19 of the flexible circuit board 11, and the dielectric elements 15 located in different columns are respectively connected in parallel through different multi-purpose signal lines 19 of the flexible circuit board 11. The multi-purpose signal lines 19 of the flexible circuit board 11 are electrically connected to the corresponding wires in the first cable 13, and then through...The adapter 20 is electrically connected to the electric field generator 30. That is, the dual-purpose signal line 19 of the flexible circuit board 11 receives the AC signal generated by the electric field generator 30 through the first cable 13 and the adapter 20.

[0056] The multiple grounding lines 18 are respectively set to correspond one-to-one with the multiple rows of the electrode unit 12. The multiple grounding lines 18 are used to short-circuit and ground the temperature sensor 14 of each electrode unit 12 in each row group in sequence. That is, the grounding terminals 14-1 of the multiple temperature sensors 14 located in the same row group are all short-circuited through the same grounding line 18 of the flexible circuit board 11, and the grounding terminals 14-1 of the temperature sensors 14 located in different rows are connected in parallel through different grounding lines 18 of the flexible circuit board 11. During the time period of temperature detection or in the second mode, only one of the multiple grounding lines 18 is conducting at the same time, and the rest are disconnected.

[0057] Each of the multiple dual-purpose signal lines 19 is also configured to transmit a DC signal to the temperature sensor 14 in each electrode unit 12 in the corresponding column group to collect and transmit the detected temperature signal. The signal terminals 14-2 of the multiple temperature sensors 14 located in different column groups are connected in parallel through different dual-purpose signal lines 19 of the flexible circuit board 11. The signal terminals 14-2 of the multiple temperature sensors 14 located in the same column group are all shorted to the same dual-purpose signal line 19 of the flexible circuit board 11, and the shorting point serves as a temperature sampling point. Specifically, each dual-purpose signal line 19 is configured to short-connect the signal terminal 14-2 of the temperature sensor 14 of at most one electrode unit 12 in each row group to an external device for receiving the detection signal. The signal terminals 14-2 of the temperature sensors 14 connected to each of the multiple dual-purpose signal lines 19 are different to avoid the dual-purpose signal line 19 from outputting duplicate signals in the future. That is, when the number of electrode units 12 in a row group is the same as the number of dual-purpose signal lines 19, each dual-purpose signal line 19 is electrically connected to the signal terminal 14-2 of the temperature sensor 14 of a different electrode unit 12 in that row group; when the number of electrode units 12 in a row group is less than the number of dual-purpose signal lines 19, at least one dual-purpose signal line 19 is not electrically connected to the signal terminal 14-2 of the temperature sensor 14 of the electrode unit 12, and the remaining dual-purpose signal lines 19 are electrically connected to the signal terminal 14-2 of the temperature sensor 14 of a different electrode unit 12 in that row group. In this embodiment, the external device for receiving the detection signal is an adapter 20. The dual-purpose signal lines 19 of the flexible circuit board 11 receive DC signals from the adapter 20 or the electric field generator 30 through the first cable 13, and transmit the collected or detected temperature signals to the adapter 20, and then to the electric field generator 30 through the adapter 20.

[0058] In this embodiment, with each electrode unit 12 equipped with a temperature sensor 14 for temperature detection, the above-mentioned circuit design reduces the number of wires in the first cable 13, avoiding the cable becoming thicker and harder, thus increasing the difficulty of cable fixation; at the same time, it avoids the increased number of wires in the first cable 13 affecting the adhesion effect between the electrode sheet 10 and the corresponding body surface of the patient's tumor site.

[0059] The flexible circuit board 11 has a total of 9 lines, including the grounding wire 18 and the dual-purpose signal line 19. In this embodiment, the flexible circuit board 11 has 4 grounding wires and 5 dual-purpose signal lines. Specifically, the electrode sheet 10 in this embodiment includes 4 grounding wires 18, each grounding wire 18 being used to ground the grounding terminals 14-1 of the temperature sensors 14 in the same row group. The 4 grounding wires 18 of the electrode sheet 10 are the first grounding wire 18-1, the second grounding wire 18-2, the third grounding wire 18-3, and the fourth grounding wire 18-4. In the four rows of electrode plates 10, the first row includes electrode units 12-1 to 12-5, the second row includes electrode units 12-6 to 12-10, the third row includes electrode units 12-11 to 12-15, and the fourth row includes electrode units 12-16 to 12-20. Specifically, the first grounding wire 18-1 is used to ground electrode units 12-1 to 12-5 in the first row; the second grounding wire 18-2 is used to ground electrode units 12-6 to 12-10 in the second row; the third grounding wire 18-3 is used to ground electrode units 12-11 to 12-15 in the third row; and the fourth grounding wire 18-4 is used to ground electrode units 12-16 to 12-20 in the fourth row. It should be noted that these grounding wires 18 can be selectively closed or opened, which can be achieved by connecting each grounding wire 18 in series with a switch, as will be described in detail below. The above-mentioned "grounding the electrode unit 12" can refer to grounding the grounding terminal 14-1 of the temperature sensor 14 in the electrode unit 12, or it can refer to the diode 16 being connected in series with the temperature sensor 14 of the same electrode unit 12 and grounded together. In short, each grounding wire 18 short-circuits and grounds the grounding terminals 14-1 of the temperature sensors 14 of all electrode units 12 in the corresponding row group. The fourth grounding wire 18-4 is also short-circuited with the grounding trace 171 connected to the grounding pin of the handshake chip 17. Specification 9 / 34 pages 12 CN 121360334 A

[0060] Continuing to refer to FIG3, the electrode sheet 10 of this embodiment also includes 5 dual-purpose signal lines 19, one end of each dual-purpose signal line 19 is connected to all electrode units 12 in each column group, and the other end is connected to a device for receiving temperature detection.The signal and the converter 20 for transmitting AC signals. That is, for each row group, each dual-purpose signal line 19 can be selectively connected to one of the electrode units 12 or not connected to any of the electrode units 12 in that row group to avoid subsequent repetitive signal output from the dual-purpose signal line 19. Specifically, the five dual-purpose signal lines 19 of the electrode sheet 10 include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric element 15 of each of the four electrode units 12 (electrode units 12-1, 12-6, 12-11, and 12-16) and the signal terminal 14-2 of their respective temperature sensors 14; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the electrode units 12-2, 12-7, 12-8, 12-9 ... 12. Each of the four electrode units 12 (12-17) has its own dielectric element 15 and its own temperature sensor 14 signal terminal 14-2. One end of the third dual-purpose signal line 19-3 is connected to the dielectric element 15 and its own temperature sensor 14 signal terminal 14-2 of each of the four electrode units 12 (12-3, 12-8, 12-13, 12-18). One end of the fourth dual-purpose signal line 19-4 is connected to the dielectric element 15 and its own temperature sensor 14 signal terminal 14-2 of each of the four electrode units 12 (12-4, 12-9, 12-14, 12-19). One end of the fifth dual-purpose signal line 19-5 is connected to the dielectric element 15 and its own temperature sensor 14 signal terminal 14-2 of each of the four electrode units 12 (12-5, 12-10, 12-15, 12-20). In short, each dual-purpose signal line 19 shorts in parallel the signal terminals 14-2 of each dielectric element 15 of each electrode unit 12 located in the same column group and each temperature sensor 14 for connection to an external device. It should be noted that these dual-purpose signal lines 19 can selectively transmit AC signals or receive temperature detection signals. This can be achieved by connecting each dual-purpose signal line 19 in series with a bidirectional switching switch 26 and coordinating the closing or opening of the grounding wire 18, which will be described in detail below.

[0061] In other embodiments, the number of grounding wires 18 and dual-purpose signal lines 19 embedded in the flexible circuit board 11 may vary depending on the circuit arrangement and number of electrode units 12 in different electrode sheets, which will be specifically described in subsequent embodiments.

[0062] In this embodiment, the grounding pin of the handshake chip 17 used by the electrode sheet 10 to confirm its connection status is embedded inThe grounding trace 171 on the flexible circuit board 11 is connected to the fourth grounding line 18-4. The first cable 13 has 10 core wires, namely 4 grounding lines 18, 5 dual-purpose signal lines 19, and 1 communication line 172. The specific connection relationship and working principle of the handshake chip 17 will be described in detail below.

[0063] The tumor electric field therapy system 100 of this embodiment includes at least one pair of the above-mentioned electrode plates 10, an adapter 20 electrically connected to the electrode plates 10, and an electric field generator 30 electrically connected to the adapter 20. The adapter 20 is connected between the electrode plates 10 and the electric field generator 30. When the electric field generator 30 or the adapter 20 controls the grounding pin of the handshake chip 17 to be grounded, the electric field generator 30 sends a handshake communication signal to the handshake chip 17 of the electrode plate 10 via the adapter 20 and the communication line 172 of the electrode plate 10 to determine the connection status of the electrode plate 10. When the electrode plate 10 is properly connected, the electric field generator 30 provides AC signals to the dielectric elements 15 in the multiple electrode units 12 of the electrode plate 10 via the adapter 20 and the dual-purpose signal line 19 of the electrode plate 10, or provides DC signals to the temperature sensors 14 in the multiple electrode units 12 of the electrode plate 10 via the adapter 20 and the dual-purpose signal line 19 of the electrode plate 10, and is used to receive temperature detection signals output by the temperature sensors 14 in the multiple electrode units 12. The adapter 20 is configured to send a handshake communication signal to the communication line 172 of the electrode plate 10 according to the communication command of the electric field generator 30, and is configured to transmit the AC signals generated by the electric field generator 30 to the dual-purpose signal line 19 of the electrode plate 10, and is also configured to transmit DC signals to the dual-purpose signal line 19 of the electrode plate and receive the temperature detection signals output by the dual-purpose signal line 19 of the electrode plate 10.

[0064] Referring again to Figures 3 and 4, the adapter 20 includes: a first controller 22, a multi-channel communication transmission line 211 electrically connected to the first controller 22, multiple sets of analog-to-digital converters 23 connected to the first controller 22, multiple sets of voltage-reducing resistors 24 and multiple sets of grounding switches 25 corresponding to each set of analog-to-digital converters 23, multiple sets of bidirectional switching switches 26 corresponding to each set of analog-to-digital converters 23, a first communication unit 27, AC signal lines 28 corresponding to each set of bidirectional switching switches 26, and a first power module 29 simultaneously connected to the first communication unit 27, the first controller 22, and the multiple sets of analog-to-digital converters 23. The first power module 29 provides DC power VCC to each electronic component of the adapter 20. The adapter 20 also includes multiple circuit lines (unlabeled). These multiple circuit lines (unlabeled) are respectively connected to the corresponding electrode plates 10 via first cables 13.The flexible circuit board 11 of electrode 10 has multiple grounding wires 18, multiple dual-purpose signal lines 19, and communication lines 172 connected one-to-one. The multiple circuit lines (unlabeled) include multiple AC signal lines 28 that transmit AC signals to the corresponding electrode 10 and are electrically connected to the multiple dual-purpose signal lines 19 in the flexible circuit board 11 of the corresponding electrode 10; multiple circuit lines (unlabeled) that are electrically connected one-to-one to the multiple dual-purpose signal lines 19 in the flexible circuit board 11 of the corresponding electrode 10 and are used to power the temperature sensors 14 of the electrode 10 or transmit the temperature detection signals of the electrode 10; multiple circuit lines (unlabeled) that are electrically connected one-to-one to the multiple grounding wires 18 in the flexible circuit board 11 of the corresponding electrode 10; and multiple communication transmission lines 211 that are electrically connected one-to-one to the multiple communication lines 172 in the flexible circuit board 11 of the corresponding electrode 10. All multiple communication transmission lines 211 are connected to the first controller 22. Each communication transmission line 211 is connected to the communication line 172 of the flexible circuit board 11 through the corresponding first connector 40, and the first controller 22 and the handshake chip 17 are electrically connected to the handshake chip 17 by shorting the grounding pin of the handshake chip 17 of the closed flexible circuit board 11 through the grounding switch 25 corresponding to the grounding line 18, so that the handshake chip 17 can obtain power and enable the data communication function.

[0065] The number P of the circuit lines P that the adapter 20 is electrically connected to one electrode piece 10 is equal to the sum of the number of rows M and the number of columns N of the electrode unit 12 of the electrode piece 10 plus 2; the number H of the circuits that the adapter 20 is electrically connected to X electrode pieces 10 is equal to X times the number of circuit lines that it is electrically connected to a single electrode piece 10. The number of grounding switches 25, the number of bidirectional switching switches 26, the number of AC lines 28 and the number of communication transmission lines 211 are all related to the number of electrode pieces 10. The number of grounding switches 25, the number of bidirectional switching switches 26, the number of AC lines 28, and the number of communication transmission lines 211 are all the same; and not less than the number of electrode pieces 10. Preferably, the number of grounding switches 25, the number of bidirectional switching switches 26, the number of AC lines 28, and the number of communication transmission lines 211 are all the same as the number of electrode pieces 10. The following is a detailed description of the electrical connection between an electrode piece 10 with 20 electrode units 12 and the adapter 20.

[0066] Each group of grounding switches 25 is provided with multiple grounding switches 25, which are respectively connected to the adapter 20 and electrically connected to the circuit lines (unlabeled) corresponding to the multiple grounding wires 18 of a corresponding electrode piece 10, and are configured to control the conduction or disconnection of the multiple grounding wires 18. The circuit lines (unlabeled) that are electrically connected to the multiple grounding wires 18 of the electrode piece 10 are grounded at the end near the grounding switch 25. The grounding switches 25 in each group of grounding switches 25The number of grounding wires 18 on the flexible circuit board 11 of the corresponding electrode sheet 10 is related to the number of grounding wires 18, and in this embodiment, the two are equal. As shown in FIG3, in this embodiment, each group of grounding switches 25 includes a first grounding switch 25-1, a second grounding switch 25-2, a third grounding switch 25-3, and a fourth grounding switch 25-4. Each group of multiple grounding switches 25 controls the closing or opening of the corresponding grounding wire 18 of a corresponding electrode sheet 10. Specifically, the first grounding switch 25-1 is used to control the opening or closing of the first grounding wire 18-1 of the corresponding electrode plate 10, and can cooperate with the corresponding set of bidirectional switching switches 26 to control the energization and de-energization of the temperature sensors 14 of the five electrode units 12 in the first row group of the electrode plate 10, from electrode unit 12-1 to electrode unit 12-5; the second grounding switch 25-2 is used to control the opening or closing of the second grounding wire 18-2 of the electrode plate 10, and can cooperate with the corresponding set of bidirectional switching switches 26 to control the five electrode units 12-6 to electrode unit 12-10 in the second row group of the electrode plate 10. (Instruction manual page 11 / 34, CN 121360334 A) Each temperature sensor 14 of electrode unit 12 is energized and de-energized; the third grounding switch 25-3 is used to control the opening or closing of the third grounding wire 18-3 of the electrode plate 10, and can cooperate with the corresponding set of bidirectional switching switches 26 to control the energization and de-energization of each temperature sensor 14 of the five electrode units 12 in the third row group of the electrode plate 10; the fourth grounding switch 25-4 is used to control the opening or closing of the fourth grounding wire 18-4 of the electrode plate 10, and can determine the connection status of the electrode plate 10 by the electrical connection status between the communication line 172 of the handshake chip 17 and the communication transmission line 211 of the adapter 20, and can also cooperate with the corresponding set of bidirectional switching switches 26 to control the energization and de-energization of each temperature sensor 14 of the five electrode units 12 in the fourth row group of the electrode plate 10. The above-mentioned grounding switch 25 can be a mechanical switch, such as a relay. The grounding switch 25 can also be an electronic switch, and each grounding switch 25 can be opened and closed by the first controller 22 of the adapter 20.

[0067] In this embodiment, multiple sets of grounding switches 25 are all electronic switches. The first controller 22 is communicatively connected to multiple sets of grounding switches 25 and is used to sequentially and cyclically control the opening and closing states of multiple grounding switches 25 in each set of grounding switches 25, thereby sequentially and individually activating each grounding wire 18 in the multiple grounding wires 18 of the corresponding electrode 10 and cooperating with the switching of the corresponding bidirectional switching switch 26, so as to sequentially and time-divisionally collect the temperature of the patient's body surface detected by all temperature sensors 14 on the electrode 10. The number of grounding switches 25 in each set is greater than or equal to the number of grounding wires 18 of the flexible circuit board 11 of the corresponding electrode 10.In the embodiment, the number of grounding switches 25 in each group is the same as the number of grounding wires 18 of the corresponding electrode sheet 10.

[0068] Each group of bidirectional switching switches 26 is provided with multiple bidirectional switching switches 26. The multiple bidirectional switching switches 26 in each group are respectively connected to the adapter 20 and electrically connected to the circuit lines (unlabeled) corresponding to the multi-channel dual-purpose signal lines 19 of the corresponding electrode sheet 10. The number of bidirectional switching switches 26 in each group of bidirectional switching switches 26 is related to the number of dual-purpose signal lines 19 of the flexible circuit board 11 of the corresponding electrode sheet 10, which is greater than or equal to the number of dual-purpose signal lines 19 of the flexible circuit board 11 of the corresponding electrode sheet 10. In the embodiment shown in FIG3, the two are equal. Each bidirectional switching switch 26 has a sampling terminal 1 and an input terminal 2. The sampling terminal 1 of the multiple bidirectional switching switches 26 in the same group is electrically connected to the corresponding detection channel in the multiple detection channels of the corresponding group of analog-to-digital converters 23. Each detection channel corresponds to the corresponding temperature sampling point. Each bidirectional switch 26 in the same group has its input terminal 2 electrically connected to the corresponding AC signal line 28. Each bidirectional switch 26 is configured to control the multiplexer signal line 19 to connect to the corresponding AC signal line 28 to transmit AC signals or to connect to the corresponding detection channel of the corresponding group of analog-to-digital converters 23 to receive the temperature detection signal output by the temperature sensor 14.

[0069] As shown in FIG3, taking an electrode plate 10 electrically connected to the adapter 20 as an example, in this embodiment with 20 electrode units 12, the multiple bidirectional switches 26 are respectively a first bidirectional switch 26-1, a second bidirectional switch 26-2, a third bidirectional switch 26-3, a fourth bidirectional switch 26-4, and a fifth bidirectional switch 26-5. The multiple bidirectional switches 26 in the same group control the switching of a corresponding dual-purpose signal line 19 in the multiplexer signal line 19 of the same electrode plate 10 between transmitting AC signals and transmitting temperature detection signals.

[0070] Specifically, the first bidirectional switching switch 26-1 is used to control the switching of the first dual-purpose signal line 19-1 of the corresponding electrode plate 10 between transmitting AC power signals and transmitting temperature detection signals, thereby controlling the switching between the conduction of each dielectric element 15 of the electrode units 12-1, 12-6, 12-11, and 12-16 in the first column of the electrode plate 10 and the conduction of the signal terminals 14-2 of each temperature sensor 14 in the first column of the electrode units 12-1, 12-6, 12-11, and 12-16, and the conduction of the signal terminals 14-2 of each temperature sensor 14 in the first column of the electrode units 12-1, 12-6, 12-11, and 12-16, and cooperating with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4, so that the first column of electrode units 12-1, 12-6, and 12-16 can transmit AC power signals and transmit temperature detection signals.Electrode units 12-11 and 12-16 transmit AC signals to the patient or output temperature detection signals collected by the temperature sensors 14 of the corresponding electrode units 12 to the corresponding analog-to-digital converter 23; the second bidirectional switch 26-2 is used to control the switching of the second dual-purpose signal line 19-2 of the corresponding electrode pad instruction manual (page 12 / 34, CN 121360334 A 10) between transmitting AC signals and transmitting temperature detection signals, thereby controlling the conduction of each dielectric element 15 of electrode units 12-2, 12-7, 12-12, and 12-17 in the second column of the electrode pad 10 and the conduction of each dielectric element 15 of electrode units 12-2, 12-7, 12-12, and 12-17 in the second column of the electrode pad 10. The switching between the conduction of the signal terminals 14-2 of each temperature sensor 14 and the corresponding grounding switches 25-1, 25-2, 25-3, and 25-4 is coordinated to enable the second row of electrode units 12-2, 12-7, 12-12, and 12-17 to transmit AC signals to the patient or output temperature detection signals collected by the temperature sensors 14 of these electrode units 12 to the corresponding analog-to-digital converter 23; the third bidirectional switching switch 26-3 is used to control the switching between transmitting AC signals and transmitting temperature detection signals on the third dual-purpose signal line 19-3 of the corresponding electrode pad 10. This control then switches between the conduction of the dielectric elements 15 of electrode units 12-3, 12-8, 12-13, and 12-18 in the third column of the electrode sheet 10 and the conduction of the signal terminals 14-2 of the temperature sensors 14 in the third column of the electrode unit 12-3, 12-8, 12-13, and 12-18, and coordinates with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4, so that the third column of electrode units 12-3, 12-8, 12-13, and 12-18 can direct the flow of electricity to the affected area. The electrode unit 12 transmits AC signals or outputs temperature detection signals collected by the temperature sensors 14 to the corresponding analog-to-digital converter 23; the fourth bidirectional switch 26-4 is used to control the switching of the fourth dual-purpose signal line 19-4 of the corresponding electrode 10 between transmitting AC signals and transmitting temperature detection signals, thereby controlling the conduction of each dielectric element 15 of the electrode units 12-4, 12-9, 12-14, and 12-19 in the fourth column of the electrode 10 and the signal terminal 14-2 of each temperature sensor 14 of the electrode units 12-4, 12-9, 12-14, and 12-19 in the fourth column of the electrode 10.The switching between the two is activated and coordinated with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4, so that the fourth column of electrode units 12-4, 12-9, 12-14, and 12-19 transmit AC signals to the patient or output temperature detection signals collected by the temperature sensors 14 of these electrode units 12 to the corresponding analog-to-digital converter 23; the fifth bidirectional switching switch 26-5 is used to control the switching of the fifth dual-purpose signal line 19-5 of the corresponding electrode sheet 10 between transmitting AC signals and transmitting temperature detection signals, thereby controlling the dielectric elements of each electrode unit 12-5, 12-10, 12-15, and 12-20 in the fifth column of the electrode sheet 10. The switching between the conduction of component 15 and the conduction of the signal terminals 14-2 of the temperature sensors 14 of each temperature sensor 14 in the fifth column group of electrode units 12-5, 12-10, 12-15, and 12-20, and cooperating with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4, enables the fifth column of electrode units 12-5, 12-10, 12-15, and 12-20 to transmit AC signals to the patient or output the temperature detection signals collected by the temperature sensors 14 of these electrode units 12 to the corresponding analog-to-digital converter 23.

[0071] When all grounding switches 25 are open and the input terminal 2 of each bidirectional switching switch 26 is on and the sampling terminal 1 is off, AC signals can be transmitted to the dielectric elements 15 of each electrode unit 12 of the corresponding electrode plate 10. When the sampling terminal 1 of each bidirectional switching switch 26 is on and the input terminal 2 is off, it can cooperate with each grounding switch 25 in the corresponding group of grounding switches 25 to transmit the temperature detection signals collected by the temperature sensors 14 of each electrode unit 12 on the electrode plate 10 in a time-division manner. The bidirectional switching switch 26 can be a mechanical switch, such as a relay. The bidirectional switching switch 26 can also be an electronic switch, and the switching between the sampling terminal 1 and the input terminal 2 of each bidirectional switching switch 26 can be controlled by the first controller 22 of the adapter 20.

[0072] In this embodiment, all of the multiple bidirectional switching switches 26 are electronic switches. The first controller 22 is communicatively connected to multiple sets of bidirectional switching switches 26. It controls the switching of multiple bidirectional switching switches 26 within each set between their respective sampling terminals 1 and input terminals 2, and coordinates with the closing or opening of corresponding grounding switches 25 to continuously monitor the patient's body surface temperature detected by all temperature sensors 14 on the electrode pads 10 or to transmit AC signals to the patient. In this embodiment, on pages 13 / 34 of document CN 121360334 A, multiple sets of grounding switches 25 and multiple sets of bidirectional switching switches 26 together constitute a switching unit (unlabeled).

[0073] In this embodiment, each group of analog-to-digital converters 23 is electrically connected one-to-one to the sampling terminals 1 of multiple bidirectional switching switches 26 in the corresponding group through multiple circuit lines (unlabeled) in the adapter 20, and is configured to receive the temperature detection signal transmitted by the multi-purpose signal line 19 of the corresponding electrode sheet 10, and convert the temperature detection signal from an analog signal to a digital signal. Each group of analog-to-digital converters 23 includes multiple detection channels A, B, C, D, and E, each detection channel A, B, C, D, and E is used to connect to one corresponding dual-purpose signal line 19 in the multi-purpose signal line 19 through the corresponding bidirectional switching switch 26. The number of detection channels in each group of analog-to-digital converters 23 is related to the number of bidirectional switching switches 26 in the corresponding group. The number of detection channels in each group of analog-to-digital converters 23 is related to the number of column groups of electrode units 12 of the corresponding electrode sheet 10. Specifically, the number of detection channels in each group of analog-to-digital converters 23 is equal to the number of bidirectional switching switches 26 in the corresponding group of bidirectional switching switches 26, and is not less than the number of column groups of electrode units 12 of the corresponding electrode sheet 10. As shown in Figure 3, each group of analog-to-digital converters 23 contains a total of 5 detection channels A, B, C, D, and E, which are the first detection channel A, the second detection channel B, the third detection channel C, the fourth detection channel D, and the fifth detection channel E, respectively. The first detection channel A is connected to the first dual-purpose signal line 19-1 through the sampling terminal 1 of the first bidirectional switching switch 26-1; the second detection channel B is connected to the second dual-purpose signal line 19-2 through the sampling terminal 1 of the second bidirectional switching switch 26-2; the third detection channel C is connected to the third dual-purpose signal line 19-3 through the sampling terminal 1 of the third bidirectional switching switch 26-3; the fourth detection channel D is connected to the fourth dual-purpose signal line 19-4 through the sampling terminal 1 of the fourth bidirectional switching switch 26-4; and the fifth detection channel E is connected to the fifth dual-purpose signal line 19-5 through the sampling terminal 1 of the fifth bidirectional switching switch 26-5. Each detection channel A, B, C, D, and E is used to receive temperature detection signals collected by the temperature sensor 14 of the corresponding electrode unit 12 connected to the dual-purpose signal line 19. Additionally, each detection channel A, B, C, D, and E is connected via a corresponding voltage divider resistor 24 within the adapter 20 to a first power module 29, which provides detection voltage to that detection channel A, B, C, D, and E. The first power module 29 provides a DC signal.

[0074] In this embodiment, the first communication unit 27 is configured to acquire multiple sets of digital signals output by the analog-to-digital converter 23 and send the digital signals to the electric field generator 30. The electric field generator 30 is also configured to control and adjust the voltage, current, or power of the AC signal provided to the multiple electrode units 12 of the electrode sheet 10 according to the received digital signals. For example, when any one of the received digital signals exceeds a preset threshold, it indicates that at least one temperature sensor in the electrode sheet 10 is at fault.If the temperature detected by the temperature sensor 14 at the surface of the human body where the corresponding dielectric element 15 is applied exceeds the preset threshold temperature (e.g., 41℃, 42℃, etc.), the voltage, current, or power of the AC signal output by the electric field generator 30 can be appropriately reduced to avoid the electrode unit 12 of the electrode sheet 10 becoming too hot when the AC signal is applied, causing low-temperature burns to the patient's skin. The preset threshold temperature and preset threshold can be determined according to the human safety threshold. The first communication unit 27 is controlled by the first controller 22 and serially transmits digital signals converted by multiple sets of analog-to-digital converters 23. In this embodiment, the preset temperature threshold can be a value within the range of 36℃-45℃.

[0075] One end of each of the multiple communication transmission lines 211 embedded in the adapter 20 is connected to the first controller 22, and the other end is electrically connected to the communication line 172, which is electrically connected to the communication pin of the handshake chip 17 of the corresponding electrode sheet 10, through the corresponding wire of the corresponding first cable 13. The grounding pin GND of the adapter 22 is also connected to the grounding pin of the handshake chip 17 of the corresponding electrode 10 through a wire electrically connected to the corresponding grounding switch 25, a grounding wire 18 connected to both the wire of the corresponding first cable 13 and the grounding trace 171, and a grounding trace 171 shorted to the grounding wire 18. That is, the first controller 22 controls the grounding switch 25 corresponding to the grounding wire 18-4 shorted to the grounding pin of the handshake chip 17 of the electrode 10 to close, and sends a handshake communication signal to the communication line 172 of the electrode 17 through the communication transmission line 211. The first controller 22 determines whether the connection between the electrode 10 and the adapter 20 is normal based on whether it can receive feedback from the communication line 172 of the electrode 10.

[0076] Referring to Figures 4 and 5, in this embodiment, the first power module 29 is electrically connected to the second power module 31 of the electric field generator 30 and is configured to supply power to the first controller 22, multiple analog-to-digital converters 23, and the first communication unit 27 of the adapter 20. Each electrode 10 is connected to the adapter 20 by a first connector 40, which is adapted to connect the corresponding electrode 10 to the adapter 20. As shown in Figure 1, the first connector 40 includes a first plug 41 located at the end of the first cable 13 away from the electrode 10 and a first socket 42 located on the adapter 20. The first plug 41 and the first socket 42 are press-type spring connectors, that is, the first connector 40 connects the adapter 20 and the electrode 10 by means of a connector. Each first cable 13 has bidirectional switching switches 26-1, 26-2, 26-3 in the corresponding group of bidirectional switching switches 26.Five wires, 26-4 and 26-5, are electrically connected in a one-to-one correspondence; four wires are electrically connected in a one-to-one correspondence with grounding switches 25-1, 25-2, 25-3, and 25-4 in the corresponding set of grounding switches 25; and one wire is electrically connected to the communication line 172 of the electrode plate 10 and the communication transmission line 211 of the adapter 20. That is, each first connector 40 is electrically connected in a one-to-one correspondence with a set of bidirectional switching switches 26, a set of grounding switches 25, and a corresponding communication transmission line 211 connected to the first controller 22 via 10 wires; and is connected to the electric field generator 30 via a corresponding AC signal line 28 of the adapter 20.

[0077] A second connector 50 is provided between the adapter 20 and the electric field generator 30. The second connector 50 is adapted to connect the electric field generator 30 to the adapter 20. The adapter 20 also includes a second cable 21 connected to the second connector 50. The second connector 50 includes a second plug 51 located at the end of the second cable 21 away from the first controller 22 and a second socket 52 located on the electric field generator 30. The second plug 51 and the second socket 52 are push-button spring connectors, meaning that the second connector 50 connects the adapter 20 to the electric field generator 30 using a connector method. Each first connector 40, such as X1, Y1, X2, and Y2, is connected to the second connector 50 via a corresponding AC signal line 28. The first connectors 40, such as X1, Y1, X2, and Y2, are respectively connected to a corresponding set of grounding switches 25, a corresponding set of analog-to-digital converters 23, and a corresponding communication transmission line 211. Each first connector 40 is connected to the second connector 50 and the corresponding set of analog-to-digital converters 23 via a corresponding set of bidirectional switching switches 26. Taking four electrode plates 10 as an example, the second cable 21 has eight wires, including four wires 1 to 4 that are electrically connected to the corresponding AC signal lines 28 and used for transmitting AC signals, one wire 5 that is electrically connected to the data receiving line RX of the first communication unit 27, one wire 6 that is electrically connected to the data transmitting line TX of the first communication unit 27, one wire 7 that is electrically connected to the VCC power line of the first power module 29, and one wire 8 that is electrically connected to the GND line of the first power module 29. The second connector 50 is connected to the first communication unit 27 through the data receiving line RX and the data transmitting line TX. The VCC pin of the second connector 50 is connected to the VCC power line of the first power module 29, and the GND pin of the second connector 50 is connected to the GND line of the first power module 29 and grounded. The VCC pin of the second connector 50 is also connected to the corresponding group of voltage regulators 24 and the corresponding group of analog-to-digital converters 23 through the VCC power line of the first power module 29.

[0078] Referring to FIG5, the electric field generator 30 includes: a second power supply module 31, a second controller 32, and an AC signal generator 34.The second communication unit 33 and a set of AC signal switches 35 are also included. The VCC pin of the second connector 50 is also electrically connected to the VCC power line of the second power module 31, and the GND pin of the second connector 50 is grounded through the GND line of the second power module 31. The second power module 31 is also connected to and supplies power to the second controller 32 and the AC signal generator 34, respectively. The second communication unit 33 is electrically connected to the wire 5 of the second connector 50 through its data receiving line RX and to the wire 6 of the second connector 50 through its data transmitting line TX, thereby realizing information interaction between the electric field generator 30 and the adapter 20. The second controller 32 is also electrically connected to the second communication unit 33, the AC signal generator 34, and a set of AC signal switches 35. The second controller 32 is configured to control the opening and closing of each AC signal switch 35 in the set of AC signal switches 35 and adjust the relevant parameters of the AC signal applied by the AC signal generator 34 according to the relevant digital signals received from the adapter 20 by the second communication unit 33. The relevant parameters of the AC signal include the voltage, current, and power of the AC signal. The AC signal generator 34 is electrically connected to a set of AC signal switches 35 and several wires 1, 2, 3, and 4 of the second connector 50 for transmitting AC signals. The set of AC signal switches 35 includes multiple AC signal switches 35 (see page 15 / 34 of the specification, CN 121360334 A), and each AC signal switch 35 corresponds to a specific electrode piece 10. Each AC signal switch 35 is electrically connected to a corresponding wire 1, 2, 3, or 4 of the second connector 50 via an AC signal connector 36, and is also electrically connected to the corresponding electrode piece 10 via corresponding wires 1, 2, 3, and 4 of the second connector 50, to transmit an AC signal to each electrode piece 10. The AC signal generator 34 is electrically connected to the set of AC signal switches 35 via a set of AC signal connectors 36.

[0079] Specifically, the number of AC signal switches 35 in the electric field generator 30 is related to the number of electrode pieces 10. In this embodiment, the number of AC signal switches 35 is equal to the number of electrode pieces 10, and both are four. The AC signal switch 35 includes a first AC signal switch 35-1, a second AC signal switch 35-2, a third AC signal switch 35-3, and a fourth AC signal switch 35-4, each electrically connected to the wires 1 to 4 of the second connector 50 respectively. One end of the first AC signal switch 35-1 is electrically connected to the AC signal generator 34 via the first AC signal wiring 36 of the electric field generator 30, and the other end is electrically connected to the corresponding AC signal transmission wire 1 in the second connector 50 via the first AC signal wiring 36-1, and to the AC signal line 28 located at port X1 of the adapter 20 via the wire 1 of the second connector 50. The AC signal line 28 located at port X1 of the adapter 20 is electrically connected to the first connector 40.The first connector 40, located at port X1 of adapter 20, is electrically connected to the corresponding electrode 10 to control whether the AC signal generator 34 supplies an AC signal to the electrode 10 electrically connected to port X1 of adapter 20. One end of the second AC signal switch 35-2 is electrically connected to the AC signal generator 34 via the second AC signal wiring 36 of the electric field generator 30, and the other end is electrically connected to the corresponding AC signal transmission wire 2 in the second connector 50 via the second AC signal wiring 36-2, and then electrically connected to the AC signal line 28 at port Y1 of adapter 20 via the wire 2 of the second connector 50. The AC signal line 28 at port Y1 of adapter 20 is electrically connected to the first connector 40, and the first connector 40 at port Y1 of adapter 20 is connected to the corresponding electrode 10. Electrical connection is provided to control whether the AC signal generator 34 supplies an AC signal to the electrode 10 electrically connected to port Y1 of the adapter 20; one end of the third AC signal switch 35-3 is electrically connected to the AC signal generator 34 through the third AC signal wiring 36-3 of the electric field generator 30, and the other end is connected to the corresponding AC signal transmission wire 3 in the second connector 50 through the AC signal wiring 36-3. The AC signal generator 34 is electrically connected to the AC signal line 28 at port X2 of the adapter 20 via the wire 3 of the second connector 50. The AC signal line 28 at port X2 of the adapter 20 is electrically connected to the first connector 40. The first connector 40 at port X2 of the adapter 20 is electrically connected to the corresponding electrode 10 to control whether the AC signal generator 34 transmits an AC signal to the electrode 10 electrically connected to port X2 of the adapter 20. One end of the fourth AC signal switch 35-4 is electrically connected to the AC signal generator 34 via the fourth AC signal wiring 36-4 of the electric field generator 30. The other end is electrically connected to the corresponding AC signal transmission wire 4 in the second connector 50 via the fourth AC signal wiring 36-4 and to the adapter 20 at port Y2 via the wire 4 of the second connector 50. The AC signal line 28 at port Y2 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at port Y2 of the adapter 20 is electrically connected to the corresponding electrode plate 10, so as to control whether the AC signal generator 34 transmits AC signal to the electrode plate 10 electrically connected to port Y1 of the adapter 20.

[0080] The working principle of the handshake chip 17 is described in detail below. The handshake chip 17 can store electrical energy when the communication line 172 transmits a high level through an external energy storage element (not shown), and release energy when the communication line 172 transmits a low level, so that the handshake chip 17 obtains enough power and works normally. Optionally, the energy storage element is a capacitor. In this way, the handshake chip 17 only needs an extra core wire for communication to work normally. The handshake chip 17 is suitable for use with external devices such as the electric field generator 30 or the adapter.The device 20 performs handshake communication to determine the connection status of each pair of electrode plates 10. After the handshake communication is completed between the handshake chip 17 and the adapter 20 and / or the electric field generator 30, the states of the bidirectional switching switch 26 and the grounding switch 25 can be combined to enable the electrode plate 10 to apply an AC signal or perform temperature acquisition. When the electrode plate 10 needs to perform temperature acquisition or temperature measurement, all the bidirectional switching switches 26 on the flexible circuit board 11 of the electrode plate 10 are located at the sampling end 1. The electric field generator 30 or the adapter 20 can sequentially close each grounding switch 25 so that the analog temperature signal of the corresponding temperature sensor 14 in each row group is simultaneously sampled by the corresponding temperature sampling point. The analog temperature signal detected by each sampled temperature sensor 14 can also be converted into a signal that can characterize the type of electrode plate 10 if the electrode plate 10 is qualified, or it can be used to characterize whether the electrode plate 10 has a temperature abnormality.

[0081] Specifically, when the first controller 22 of the adapter 20 receives the handshake signal sent by the electric field generator 30, it controls the corresponding grounding switch 25 connected to the grounding pin of the handshake chip 17 to close, so that the handshake chip 17 is powered on and sends the handshake signal to the handshake chip 17. The handshake chip 17 sends a feedback signal, and the first controller 22 on the adapter 20 sends the feedback signal of the handshake chip 17 to the second controller 32 of the electric field generator 30 through the second connector 50. The second controller 32 determines whether the corresponding first controller 22 and the handshake chip 17 have completed handshake communication according to the feedback signal of the handshake chip 17, and after the handshake communication is completed, it configures the state of each grounding switch 25 and each bidirectional switching switch 26 in the switch unit (unlabeled) on the adapter 20 to transmit AC signals to the dielectric elements of each electrode unit 12 of the electrode sheet 10 or to measure the temperature through the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10. When the electrode 10 is in temperature acquisition mode, the electric field generator 30 controls each bidirectional switching switch 26 of the adapter 20 through its second controller 32 to make each bidirectional switching switch 26 be in its respective acquisition terminal 1, and sequentially closes each grounding switch 25, so that each detection channel of the corresponding analog-to-digital converter 23 acquires the temperature detection signal of each temperature sensor 14 in a row, and performs analog-to-digital conversion on the acquired several temperature analog signals to obtain several AD sampling values, which correspond to digital temperature. The first controller 22 can also send several AD sampling values ​​to the electric field generator 30 through the adapter 20, so that if the electrode 10 is qualified, the electric field generator 30 can identify the type of the corresponding electrode 10 according to several AD sampling values, and / or, during the transmission of alternating electrical signals to the corresponding electrode 10, determine whether the corresponding electrode 10 has a temperature abnormality according to several AD sampling values.

[0082] The working principle of the tumor electric field therapy system 100 of this embodiment will be described in detail below with reference to Figures 3 to 5.

[0083] The second controller 32 of the electric field generator 30 controls the grounding switch 25-4 corresponding to the fourth grounding line 18-4 connected to the handshake chip 17 of the electrode 10 to be in a closed state through the first controller 22 of the adapter 20, and sends a handshake signal to the communication line 172 of the electrode 10 through the first controller 22, and determines the connection status between the electrode 10 and the adapter 20 according to whether the feedback from the handshake chip 17 can be received. If the electric field generator 30 can receive the feedback signal from the electrode 10, it means that the connection between the electrode 10 and the adapter 20 is normal; then the AC signal can be applied to the electrode 10 or the temperature detection signal can be collected through the temperature sensor 14 of the electrode 10. If the electric field generator 30 does not receive the feedback signal from the electrode 10, it means that the connection between the electrode 10 and the adapter 20 is abnormal, and the second controller 32 of the electric field generator 30 issues a connection abnormality prompt to remind the operator. After the operator handles the issue, the second controller 32 continues to control the first controller 22 of the adapter 20 to send a handshake communication signal to the handshake chip 17 of the electrode 10, repeating the above-mentioned operation of judging the connection status of the electrode 10 until the electrode 10 and the adapter 20 are connected normally.

[0084] When the electrode plate 10 is connected normally and the temperature of each electrode unit 12 of a certain electrode plate 10 needs to be detected, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls the sampling terminal 1 of each of the multiple bidirectional switching switches 26 electrically connected to the electrode plate 10 to be turned on and the input terminal 2 to be turned off, so as to disconnect the AC signal applied to the electrode plate 10; at the same time, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls each of the grounding switches 25 electrically connected to the electrode plate 10 to be turned on in sequence. At this time, the temperature detection signal collected by each temperature sensor 14 of each electrode unit 12 in each row of the electrode plate 10 can be collected in sequence in time through the multiple detection channels A, B, C, D, E of the set of analog-to-digital converters 23 corresponding to the electrode plate 10. Each detection channel A, B, C, D, and E of each group of analog-to-digital converters 23 simultaneously acquires only the temperature detection signal from the temperature sensor 14 of the corresponding electrode unit 12 in the same row of electrode plates 10. This temperature detection signal can be characterized by a voltage value. Of the four grounding switches 25 corresponding to the electrode plate 10, only one can be on at any given time; the other three must be off. (See instruction manual for the bidirectional switching switch corresponding to this group of analog-to-digital converters 23, page 17 / 34, CN 121360334 A).All five bidirectional switching switches 26 are switched to their respective sampling terminals 1 so that the dual-purpose signal lines 19 of the electrode plate 10 are electrically connected to the corresponding detection channels A, B, C, D, and E of the corresponding analog-to-digital converter 23 and thus conduction is achieved. With this configuration, the group of analog-to-digital converters 23 can collect the voltage values ​​of all temperature sensors 14 of each electrode unit 12 in the same row group that are shorted to one grounding line 18 corresponding to the conducting grounding switch 25.

[0085] Specifically, when the first grounding switch 25-1 is closed, the second grounding switch 25-2, the third grounding switch 25-3, and the fourth grounding switch 25-4 are all open, and the first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, the third bidirectional switching switch 26-3, the fourth bidirectional switching switch 26-4, and the fifth bidirectional switching switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of the electrode units 12-1 to 12-5 in the first row group are energized, and the electrode units 12-6 in the other rows are energized. When the temperature sensors 14 of electrode units 12-20 are de-energized, the signal terminals 14-2 of the temperature sensors 14 of electrode units 12-1, 12-6, 12-11, and 12-16 are shorted on the first detection channel A of the analog-to-digital converter 23. Since only the ground terminal 14-1 of the temperature sensor 14 of electrode unit 12-1 is connected to ground, while the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-6, 12-11, and 12-16 are disconnected, and each electrode unit 12 is provided with a diode 16 connected in series with the temperature sensor 14, the other temperature sensors 14 in the first row will not affect the resistance value of the temperature sensor 14 of electrode unit 12-1. Therefore, only the temperature sensor 14 of electrode unit 12-1 is effectively operating on the first detection channel A of the analog-to-digital converter 23, and the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 of electrode unit 12-1. Similarly, the voltage value collected on the second detection channel B in this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-2. The voltage value collected on the third detection channel C in this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-3. The voltage value collected on the fourth detection channel D in this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-4. The voltage value collected on the fifth detection channel E in this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-5.

[0086] When the second grounding switch 25-2 is closed, the first grounding switch 25-1, the third grounding switch 25-3 and the fourth grounding switch 25-4 are all open, and the first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, and the third bidirectional switching switch 26-3. When both the fourth bidirectional switching switch 26-4 and the fifth bidirectional switching switch 26-5 are switched to their respective sampling terminals 1, the temperature sensors 14 of electrode units 12-6 to 12-10 in the second row group are energized, while the temperature sensors 14 of electrode units 12-1 to 12-5 and electrode units 12-11 to 12-20 in the other rows are de-energized. The signal terminals 14-2 of the temperature sensors 14 of electrode units 12-1, 12-6, 12-11, and 12-16 are short-circuited on the first detection channel A of the analog-to-digital converter 23 in this group. Since only the ground terminal 14-1 of the temperature sensor 14 of electrode unit 12-6 is connected... The circuit is grounded, while the grounding terminals 14-1 of the temperature sensors 14 of electrode units 12-1, 12-11, and 12-16 are all disconnected. Each electrode unit 12 has a diode 16 connected in series with the temperature sensor 14. The other temperature sensors 14 in the second row do not affect the resistance of the temperature sensor 14 in electrode unit 12-6. Therefore, only the temperature sensor 14 of electrode unit 12-6 is effectively operating on the first detection channel A of this group of analog-to-digital converters 23. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 in electrode unit 12-6. Similarly, the voltage value collected on the second detection channel B of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 in electrode unit 12-7. The voltage value collected on the third detection channel C of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 in electrode unit 12-8. The voltage value acquired on the fourth detection channel D of the analog-to-digital converter 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-9. The voltage value acquired on the fifth detection channel E of the analog-to-digital converter 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-10.

[0087] When the third grounding switch 25-3 is closed, the first grounding switch 25-1, the second grounding switch 25-2, and the fourth grounding switch 25-4 are all open, and the first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, the third bidirectional switching switch 26-3, the fourth bidirectional switching switch 26-4, and the fifth bidirectional switching switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of the electrode units 12-11 to 12-15 in the third row group are energized, and the temperature sensors 14 of the electrode units 12-1 to 12-10 and the electrode units 12-16 to 12-20 in the other rows are de-energized. Electrode units 12-1, 12-6, 12-11, and 12-20 are short-circuited on the first detection channel A of the analog-to-digital converter 23 in this group.Since only the grounding terminal 14-1 of the temperature sensor 14 in electrode unit 12-11 is connected to ground, while the grounding terminals 14-1 of the temperature sensor 14 in electrode units 12-1, 12-6, and 12-16 are disconnected, and each electrode unit 12 has a diode 16 connected in series with the temperature sensor 14, the other temperature sensors 14 in the third row will not affect the resistance value of the temperature sensor 14 in electrode unit 12-11. Therefore, only the temperature sensor 14 in electrode unit 12-11 is effectively operating on the first detection channel A of this group of analog-to-digital converters 23. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 in electrode unit 12-11. Similarly, the voltage value collected on the second detection channel B of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 in electrode unit 12-12. The voltage value acquired on the third detection channel C of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-13. The voltage value acquired on the fourth detection channel D of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-14. The voltage value acquired on the fifth detection channel E of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-15.

[0088] When the fourth grounding switch 25-4 is closed, the first grounding switch 25-1, the second grounding switch 25-2, and the third grounding switch 25-3 are all open, and the first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, the third bidirectional switching switch 26-3, the fourth bidirectional switching switch 26-4, and the fifth bidirectional switching switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of the electrode units 12-16 to 12-20 of the fourth row group are energized, and the temperature sensors 14 of the electrode units 12-1 to 12-15 of the other row groups are de-energized. The signal terminals 14- of the temperature sensors 14 of the electrode units 12-1, 12-6, 12-11, and 12-16 of the first detection channel A in this group of analog-to-digital converters are short-circuited. 2. Since only the grounding terminal 14-1 of the temperature sensor 14 in electrode unit 12-16 is connected to ground, while the grounding terminals 14-1 of the temperature sensors 14 in electrode units 12-1, 12-6, and 12-11 are disconnected, and each electrode unit 12 has a diode 16 connected in series with the temperature sensor 14, the remaining temperature sensors 14 in the fourth row will not affect the resistance value of the temperature sensor 14 in electrode unit 12-16. Therefore, only the temperature sensor 14 of electrode unit 12-16 is effectively operating on the first detection channel A of this group of analog-to-digital converters 23. At this time, the temperature detection signal (voltage) collected by the first detection channel A is...The voltage value is the voltage value of the temperature sensor 14 of electrode units 12-16. Similarly, the voltage value collected on the second detection channel B of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode units 12-17. The voltage value collected on the third detection channel C of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode units 12-18. The voltage value collected on the fourth detection channel D of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode units 12-19. The voltage value collected on the fifth detection channel E of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode units 12-20. Thus, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 can collect the temperature detection signals of the temperature sensors 14 of all electrode units 12 of the electrode unit 10 by controlling a set of bidirectional switching switches 26 and a set of grounding switches that are electrically connected to a certain electrode piece 10. Similarly, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of other electrode plates 10 can be obtained.

[0089] The first controller 22, multiple sets of analog-to-digital converters 23 and multiple sets of bidirectional switching switches 26 can be automatically executed by pre-programmed program code. For example, the first controller 22 first controls all bidirectional switching switches 26 in the corresponding set to switch to the sampling end 1 so that the sampling end 1 of these bidirectional switching switches 26 is all turned on and the input end 2 is all turned off so that each dual-purpose signal line 19 of the corresponding electrode plate 10 is electrically connected to the corresponding set of analog-to-digital converters 23. Then, the first grounding switch 25-1 in the corresponding set of grounding switches 25 is closed, and the remaining second grounding switches 25-2, third grounding switches 25-3 to fourth grounding switches 25-4 in the set of grounding switches 25 are opened. During this period, each detection channel A, B, C of the set of analog-to-digital converters 23 is opened. D and E acquire the temperature detection signals of each temperature sensor 14 of each electrode unit 12 located in the first row group of the corresponding electrode sheet 10, convert them into digital signals, and store them in a separately set memory. Then, after a preset interval, the first controller 22 closes the second grounding switch 25-2 in the group of grounding switches 25, and opens the first grounding switch 25-1, the third grounding switch 25-3, and the fourth grounding switch 25-4 in the group of grounding switches 25. During this period, the detection channels A, B, C, D, and E of the group of analog-to-digital converters 23 acquire the temperature detection signals of each temperature sensor 14 of each electrode unit 12 located in the second row group. By sequentially turning on each grounding switch 25 in the group of grounding switches 25, the temperature detection signals of all temperature sensors 14 in each row group of the electrode sheet 10 can be obtained. Similarly, through this operation, the temperature detection signals of all temperature sensors 14 on at least one pair of electrode sheets 10 can be obtained.

[0090] The tumor electric field therapy system 100 of this application can achieve real-time and comprehensive monitoring of the temperature of all electrode units 12 on the electrode sheet 10 without increasing the weight of the electrode sheet 10 or the number of wire cores of the first cable 13 electrically connected to the electrode sheet 10. It can then determine whether the electrode sheet 10 is qualified based on the obtained temperature detection signal; or determine whether the temperature sensor 14 of the electrode sheet 10 is faulty or abnormal based on the obtained temperature detection signal, and determine whether the electrode sheet 10 needs to be replaced based on the number of faulty or abnormal temperature sensors 14; or, if the electrode sheet is qualified, identify the electrode sheet type based on the obtained temperature detection signal; or, if the electrode sheet is qualified, determine whether the electrode unit 12 of the electrode sheet 10 is overheated based on the obtained temperature detection signal, and then control the alternating electrical signal applied to the electrode sheet 10 or the corresponding column of electrode units 12 of the electrode sheet 10, thereby avoiding low-temperature burns to the patient's body surface during tumor treatment through the electrode sheet 10. Furthermore, the flexible circuit board 11 of the electrode sheet 10 of this application is electrically connected to the dielectric element 15 of the same electrode unit 12 and the signal terminal 14-2 of the temperature sensor 14 through the same dual-purpose signal line 19. This allows for the transmission of both AC signals and DC signals for temperature signal acquisition, as well as the acquired temperature detection signal, via the dual-purpose signal line 19. Simultaneously, it significantly reduces the number of conductive traces (grounding line 18, dual-purpose signal line 19) laid on it, reducing the wiring difficulty of the flexible circuit board 11, simplifying the manufacturing process, reducing the weight of the flexible circuit board 11, and lowering manufacturing costs. The electrode sheet 10 of this application can also switch between applying AC signals for tumor treatment and transmitting DC signals for temperature acquisition and transmitting the acquired temperature detection signal through a combination of a grounding switch 25 electrically connected to the grounding line 18 and a bidirectional switching switch 26 electrically connected to the dual-purpose signal line 19.

[0091] When the electrode pad 10 is properly connected and an AC signal needs to be applied to the patient through each electrode unit 12 of a certain electrode pad 10, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls all grounding switches 25 in a set of grounding switches 25 corresponding to the electrode pad 10 to be disconnected, and simultaneously controls all bidirectional switching switches 26 in a set of bidirectional switching switches 26 corresponding to the electrode pad 10 to be switched to their respective input terminals 2, so that the sampling terminals 1 of these bidirectional switching switches 26 are all disconnected and the input terminals 2 are all turned on, so that each dual-purpose signal line 19 of the electrode pad 10 is electrically connected to an AC signal line 28 corresponding to the adapter 20 and the electrode pad 10, thereby transmitting the AC signal to each electrode unit 12 of the electrode pad 10. When the temperature detection signal of the temperature sensor 14 of all electrode units 12 of the electrode pad 10 is much lower than the detected temperature signal, the AC signal is transmitted to each electrode unit 12 of the electrode pad 10.When the preset temperature threshold is stored in the electric field generator 30 or the adapter 20, the electric field generator 30 controls the AC signal generator 34 through its second controller 32 to continue generating an AC signal with an increased voltage or current amplitude or a constant voltage or current amplitude. This signal is then transmitted to the corresponding counter electrode 10 through a corresponding AC signal line 28 of the adapter 20, so that the counter electrode 10 continues to receive an AC signal. When the temperature detection signal of the temperature sensor 14 of all electrode units 12 of the detected electrode 10 is low... (Instruction manual 20 / 34 pages 23 CN 121360334 A) When the temperature approaches a preset temperature threshold stored in the electric field generator 30 or adapter 20, the electric field generator 30 can reduce the voltage or current of the AC signal generated by the AC signal generator 34 through the second controller 32, thereby reducing the voltage or current of the AC signal applied to the electrode plate 10; when the temperature detection signal of the temperature sensor 14 of an electrode unit 12 on a certain electrode plate 10 is detected to be greater than the preset temperature threshold, the electric field generator 30 controls the AC signal switch 35 electrically connected to the electrode plate 10 to disconnect through the second controller 32. To stop applying an alternating current signal to the electrode 10; or the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 controls all bidirectional switching switches 26 in a set of bidirectional switching switches 26 electrically connected to the electrode 10 to switch from their input terminals 2 to their sampling terminals 1, that is, to control all bidirectional switching sampling terminals 1 of all bidirectional switching switches 26 in a set of bidirectional switching switches 26 electrically connected to the electrode 10 to be fully turned on and all input terminals 2 to be fully turned off, thereby stopping the application of an alternating current signal to the electrode 10 for a time limit; or, when a certain electrode 10 is detected... When the temperature detection signal of the temperature sensor 14 of an electrode unit 12 is greater than a preset temperature threshold, the second controller 32 of the electric field generator 30 controls the AC signal switch 35 electrically connected to the electrode plate 10 to continue to conduct. The second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 controls a bidirectional switching switch 26 electrically connected to the electrode unit 12 of the electrode plate 10 to switch from its input terminal 2 to its sampling terminal 1. Simultaneously, the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 controls the input terminals 2 of the remaining bidirectional switching switches 26 electrically connected to electrode units 12 in different columns from those whose temperature detection signals do not exceed the preset temperature threshold to remain electrically connected. This stops applying AC signals to all electrode units 12 in the column where the temperature detection signal exceeds the preset temperature threshold, and continues applying AC signals to the remaining column electrode units 12 whose temperature detection signals do not exceed the preset temperature threshold. This enables the tumor electric field therapy system 100 based on temperature detection.A control method for applying AC signals in different regions. When applying AC signals, all grounding switches 25 are disconnected.

[0092] In this embodiment, the grounding switches 25 that are electrically connected to the multiple grounding lines 18 of the electrode plate 10 and the bidirectional switching switches 26 that are electrically connected to the multiple dual-purpose signal lines 19 of the electrode plate 10 are all located in the adapter 20. However, in other embodiments, the grounding switches 25 that are electrically connected to the grounding lines 18 and the bidirectional switching switches 26 that are electrically connected to the dual-purpose signal lines 19 can also be located on the electrode plate 10 or in the electric field generator 30, which will not be described in detail here. In addition, the analog-to-digital converter 23 located in the adapter 20 can also be located in the electric field generator 30 and directly controlled by the second controller 32.

[0093] This application also provides other embodiments of the electrode plate 10. The differences between the multiple embodiments are mainly the different number of electrode units 12 and / or the different circuit distribution of the electrode units 12, which will be described separately below.

[0094] Figure 6 is a circuit connection diagram of the tumor electric field therapy system used in the second embodiment of this application, showing the circuit connection diagram between the electrode sheet 10D of the second embodiment and the adapter 20 of the first embodiment shown in Figure 1. The circuit is described below using the electrode sheet 10D of the second embodiment as an example. In terms of electrical connection, the electrode sheet 10D differs from the electrode sheet 10 of the first embodiment in the number of electrode units 12 and the circuit arrangement. The electrode sheet 10D in this embodiment has 13 of the aforementioned electrode units 12. In terms of electrical connection, the flexible circuit board 11D of the electrode sheet 10D arranges these 13 electrode units 12 in three rows and five columns in the circuit, where each of the two rows has 5 electrode units 12, and the remaining row has 3 electrode units 12. The flexible circuit board 11D of the electrode sheet 10D is embedded with 3 grounding lines 18, 5 dual-purpose signal lines 19, 1 grounding trace 171 that is simultaneously connected to the grounding pin of the handshake chip 17 and any grounding line 28, and 1 communication line 172 that is connected to the communication pin of the handshake chip 17. Each grounding line 18 is used to ground the grounding terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in the corresponding row group. Each dual-purpose signal line 19 is short-circuited to the dielectric element 15 of each electrode unit 12 in each column group and the signal terminal 14-2 of each temperature sensor 14, for receiving temperature detection signals or transmitting AC signals. One of the grounding lines 18 connected to the grounding trace 171 also grounds the grounding pin of the handshake chip 17.

[0095] The three grounding lines 18 of the flexible circuit board 11D are the first grounding line 18-1, the second grounding line 18-2, and the third grounding line 18-3. In the three rows of the electrode sheet 10D, the first row includes electrode units 12-1 to 12-5, and the second row...The first row includes electrode units 12-6 to 12-10, and the second row includes electrode units 12-11 to 12-13. Specifically, the first grounding line 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-1 to 12-5 in the first row; the second grounding line 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-6 to 12-10 in the second row; the third grounding line 18-3 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-11 to 12-13 in the third row and is also used to ground the grounding pin of the handshake chip 17 through the grounding trace 171 connected to the grounding pin of the handshake chip 17. In short, each grounding line 18 short-circuits and grounds the grounding terminals 14-1 of the temperature sensors 14 of all electrode units 12 in the corresponding row group, and one of the grounding lines 18 also short-circuits and grounds the grounding pin of the handshake chip 17.

[0096] The five dual-purpose signal lines 19 of the electrode sheet 10D include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. The first dual-purpose signal line 19-1 One end of the first dual-purpose signal line 19-2 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode units 12-1, 12-6, and 12-11) and the signal terminal 14-2 of their respective temperature sensors 14; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode units 12-2, 12-7, and 12-12) and the signal terminal 14-2 of their respective temperature sensors 14; one end of the third dual-purpose signal line 19-3 is simultaneously connected to electrode units 12-3 and 12-8. Each of the three electrode units 12 (electrode units 12-13) has its own dielectric element 15 and its own temperature sensor 14 signal terminal 14-2; one end of the fourth dual-purpose signal line 19-4 is simultaneously connected to the dielectric element 15 and the temperature sensor 14 signal terminal 14-2 of each of the two electrode units 12 (electrode units 12-4 and 12-9); one end of the fifth dual-purpose signal line 19-5 is simultaneously connected to the dielectric element 15 and the temperature sensor 14 signal terminal 14-2 of each of the two electrode units 12 (electrode units 12-5 and 12-10). In short, each dual-purpose signal line 19 short-circuits the dielectric element 15 and the temperature sensor 14 signal terminal 14-2 of each electrode unit 12 located in a corresponding column group and connects them to the adapter 20.

[0097] The first grounding switch 25-1, the second grounding switch 25-2, and the third grounding switch 25-3 on the adapter 20 are connected through the firstA connector 40D is electrically connected to the first grounding wire 18-1, the second grounding wire 18-2, and the third grounding wire 18-3 of the electrode plate 10D, respectively. The fourth grounding switch 25-4 is in an idle and open state. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, the fourth bidirectional switch 26-4, and the fifth bidirectional switch 26-5 on the adapter 20 are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, the fourth dual-purpose signal line 19-4, and the fifth dual-purpose signal line 19-5 of the electrode plate 10D, respectively, via the first connector 40D. A communication transmission line 211 on the adapter 20 is electrically connected to the communication line 172, which is connected to the communication pin of the handshake chip 17 of the electrode plate 10D.

[0098] The tumor electric field therapy system formed by the electrode 10D, the adapter 20 and the electric field generator 30 operates in the same way as the aforementioned tumor electric field therapy system 100. The second controller 32 of the electric field generator 30 sends a handshake communication signal to the first controller 22 of the adapter 20, and closes the third grounding switch 25-3 which is electrically connected to the handshake chip 17 of the electrode 10 through the first controller 22 of the adapter 20 or by directly controlling it. The handshake chip 17 is powered on. At this time, the first controller 22 sends a handshake communication signal to the handshake chip, and confirms that the electrode 10 is connected normally after receiving the feedback signal from the handshake chip 17. If no feedback signal is received from the handshake chip 17, it is confirmed that the electrode 10 is connected abnormally. When the electrode 10 is connected normally, the electric field transmitter 30 or the adapter 20 controls 1) all grounding switches 25 to be disconnected and the input terminals 2 and sampling terminals 1 of all bidirectional switching switches 26 to be turned on and off, so that all dual-purpose signal lines 19 and AC signal lines 28 are connected. At this time, all electrode units 12 of the electrode 10 can apply AC signals; 2) the sampling terminals 1 and input terminals 2 of all bidirectional switching switches 26 are turned on and off, and the grounding switches 25 are turned on in sequence, so that the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of each row group of the electrode 10 can be obtained in sequence. Among them, no operation is required for the grounding switches 25 that are in the idle disconnected state.

[0099] Referring to FIG7, it is a circuit connection diagram of the tumor electric field therapy system of the third embodiment of this application, showing a circuit connection diagram of the electrode 10E of the third embodiment and the adapter 20 shown in FIG1. The electrode sheet 10E, like the electrode sheet 10D in the second embodiment, has 13 electrode units 12, but the specific circuit layout is different. The flexible circuit board 11E of the electrode sheet 10E also arranges these 13 electrode units 12 in three rows and five columns, except that two of the rows are arranged differently.Each row has 4 electrode units 12, and the remaining row has 5 electrode units 12. The flexible circuit board 11E of the electrode sheet 10E also embeds 3 grounding lines 18, 5 dual-purpose signal lines 19, 1 grounding trace 171 that is simultaneously connected to the ground pin of the handshake chip 17 and any grounding line 28, and 1 communication line 172 that is connected to the communication pin of the handshake chip 17. Each grounding line 18 is used to ground the ground terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in the corresponding row group. Each dual-purpose signal line 19 shorts the dielectric element 15 of each electrode unit 12 in each column group and the signal terminal 14-2 of each temperature sensor 14, for receiving temperature detection signals or transmitting AC signals. One of the grounding lines 18 connected to the grounding trace 171 also grounds the ground pin of the handshake chip 17.

[0100] The three grounding wires 18 of the electrode sheet 10E include a first grounding wire 18-1, a second grounding wire 18-2, and a third grounding wire 18-3. The first row group includes electrode units 12-1 to 12-4, the second row group includes electrode units 12-5 to 12-8, and the third row group includes electrode units 12-9 to 12-13. Specifically, the first grounding wire 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-1 to electrode unit 12-4 in the first row group; the second grounding wire 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-5 to electrode unit 12-8 in the second row group; and the third grounding wire 18-3 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-9 to electrode unit 12-13 in the third row group, and grounds the grounding pin of the handshake chip 17 through the grounding trace 171 connected to the grounding pin of the handshake chip 17. In short, each grounding wire 18 short-circuits and grounds the grounding terminals 14-1 of the temperature sensors 14 of all electrode units 12 in each row group, and one grounding wire 18 also short-circuits and grounds the grounding pin of the handshake chip 17.

[0101] The five dual-purpose signal lines 19 of the electrode sheet 10E include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode unit 12-1, electrode unit 12-5, and electrode unit 12-9) and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode unit 12-2, electrode unit 12-6, and electrode unit 12-10) and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the third dual-purpose signal line 19-3 is simultaneously connected to the electrode unit 12-1, electrode unit 12-6, and electrode unit 12-10.Each of the three electrode units 12 (12-3, 12-7, and 12-11) has its dielectric element 15 and its respective temperature sensor 14 signal terminal 14-2 connected to both the dielectric element 15 and the signal terminal 14-2 of the temperature sensor 14 of each of the three electrode units 12 (12-4, 12-8, and 12-12). One end of the fifth dual-purpose signal line 19-5 is simultaneously connected to both the dielectric element 15 and the signal terminal 14-2 of the temperature sensor 14 of the electrode unit 12-13. In short, each dual-purpose signal line 19 short-circuits the dielectric element 15 and the signal terminal 14-2 of the temperature sensor 14 of each electrode unit 12 located in a corresponding column group and connects them to the adapter 20.

[0102] The first grounding switch 25-1, the second grounding switch 25-2, and the third grounding switch 25-3 on the adapter 20 are electrically connected to the first grounding wire 18-1, the second grounding wire 18-2, and the third grounding wire 18-3 of the electrode plate 10E respectively via connector 40E on pages 23 / 34 of the specification (CN 121360334 A). The fourth grounding switch 25-4 is in an idle and disconnected state. The first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, the third bidirectional switching switch 26-3, the fourth bidirectional switching switch 26-4, and the fifth bidirectional switching switch 26-5 on the adapter 20 are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, the fourth dual-purpose signal line 19-4, and the fifth dual-purpose signal line 19-5 of the electrode plate 10E respectively via connector 40E. A communication transmission line 211 on the adapter 20 is electrically connected to a communication line 172 connected to the communication pin of the handshake chip 17 of the electrode 10E.

[0103] The working mode of the tumor electric field therapy system formed by the electrode 10E, the adapter 20 and the electric field generator 30 is the same as that of the aforementioned tumor electric field therapy system 100. After the electric field generator 30 controls the adapter 20 to complete the handshake communication with the handshake chip 17 of the electrode 10E and confirms that the electrode 10E is connected normally, when all grounding switches 25 are open and the input terminal 2 of all bidirectional switching switches 26 is on and the sampling terminal 1 is off, all dual-purpose signal lines 19 and AC signal lines 28 are on, and all electrode units 12 can be applied with AC signals; when the sampling terminal 1 of all bidirectional switching switches 26 is on and the input terminal 2 is off, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 in each row group can be obtained sequentially by turning on each grounding switch 25 in sequence. Among them, no operation is required for the grounding switches 25 that are in the idle and disconnected state.

[0104] Referring to FIG8, the electrode sheet 10F of the fourth embodiment, like the electrode sheet 10D of the third embodiment, has 13 [missing information].The electrode units 12 are arranged in four rows and four columns, but the specific circuit layout is different. The flexible circuit board 11F of the electrode sheet 10F arranges these 13 electrode units 12 in four rows and four columns. Three rows each have four electrode units 12, and the remaining row has one electrode unit 12. The electrode sheet 10F includes four ground lines 18, four dual-purpose signal lines 19, one ground trace 171 that connects to the ground pin of the handshake chip 17 and any ground line 28, and one communication line 172 that connects to the communication pin of the handshake chip 17. Each ground line 18 is used to ground the ground terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in the corresponding row. Each dual-purpose signal line 19 shorts the dielectric element 15 of each electrode unit 12 in each column and the signal terminal 14-2 of each temperature sensor 14, for receiving temperature detection signals or transmitting AC signals. One ground line 18 connected to the ground trace 171 also grounds the ground pin of the handshake chip 17.

[0105] The four grounding wires 18 of the electrode sheet 10F include a first grounding wire 18-1, a second grounding wire 18-2, a third grounding wire 18-3, and a fourth grounding wire 18-4. The first row group includes electrode units 12-1 to 12-4, the second row group includes electrode units 12-5 to 12-8, the third row group includes electrode units 12-9 to 12-12, and the fourth row group includes electrode unit 12-13. Specifically, the first grounding wire 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-1 to electrode unit 12-4 in the first row group; the second grounding wire 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-5 to electrode unit 12-8 in the second row group; the third grounding wire 18-3 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-9 to electrode unit 12-12 in the third row group; and the fourth grounding wire 18-4 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-13 in the fourth row group. The fourth grounding wire 18-4 is also connected to the grounding trace 171 connected to the grounding pin of the handshake chip 17. In short, each grounding wire 18 short-circuits and grounds the grounding terminals 14-1 of the temperature sensors 14 of all electrode units 12 in each row group, and one of the grounding wires 18 also short-circuits and grounds the grounding pin of the handshake chip 17.

[0106] The four dual-purpose signal lines 19 of the electrode sheet 10F include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, and a fourth dual-purpose signal line 19-4. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric element of each of the four electrode units 12: electrode unit 12-1, electrode unit 12-5, electrode unit 12-9, and electrode unit 12-13.The first dual-purpose signal line 19-2 connects to the signal terminals 14-2 of each of the three electrode units 12 (electrode units 12-2, 12-6, and 12-10) and their respective temperature sensors 14-2. The second dual-purpose signal line 19-2 connects to the dielectric elements 15 of each of the three electrode units 12 (electrode units 12-2, 12-6, and 12-10) and their respective temperature sensors 14-2. The third dual-purpose signal line 19-3 connects to the dielectric elements 15 of each of the three electrode units 12 (electrode units 12-3, 12-7, and 12-11) and their respective temperature sensors 14-2. The fourth dual-purpose signal line 19-4 connects to the dielectric elements 15 of each of the three electrode units 12 (electrode units 12-4, 12-8, and 12-12) and their respective temperature sensors 14-2. In short, each dual-purpose signal line 19 shorts in parallel the signal terminals 14-2 of the dielectric elements 15 and temperature sensors 14 of each electrode unit 12 located in the same column group and connects them to the adapter 20.

[0107] The first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3 and the fourth grounding switch 25-4 on the adapter 20 are electrically connected to the first grounding wire 18-1, the second grounding wire 18-2, the third grounding wire 18-3 and the fourth grounding wire 18-4 of the electrode plate 10F respectively through the first connector 40F. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, and the fourth bidirectional switch 26-4 on the adapter 20 are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, and the fourth dual-purpose signal line 19-4 respectively via the first connector 40F. The fifth bidirectional switch 26-5 is in an idle and disconnected state. A communication transmission line 211 on the adapter 20 is electrically connected to the communication line 172, which is connected to the communication pin of the handshake chip 17 on the electrode plate 10F.

[0108] The tumor electric field therapy system formed by the electrode 10F, the adapter 20, and the electric field generator 30 operates in the same way as the aforementioned tumor electric field therapy system 100. After the handshake communication is completed with the first controller 22 of the adapter 20 through the handshake chip 17 and the connection of the electrode 10F is confirmed to be normal, when all grounding switches 25 are open and the input terminals 2 of all bidirectional switching switches 26 are turned on, all dual-purpose signal lines 19 and AC signal lines 28 are turned on, and all electrode units 12 are connected to AC signals. When the sampling terminals 1 of all bidirectional switching switches 26 are turned on, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 in each row group can be obtained sequentially by turning on each grounding switch 25 in sequence. Among them, for the grounding switches 25 that are idle and / or idleThe bidirectional switching switch 26 can be left unoperated.

[0109] Referring to FIG9, it is a schematic diagram of the circuit connection between the electrode sheet and the adapter 20 in another embodiment of the tumor electric field therapy system of this application. In terms of electrical connection, the electrode sheet 10H in this embodiment differs from the aforementioned electrode sheet in that the number of electrode units 12 and the arrangement of the electrode units 12 in the circuit connection are different. In this embodiment, the electrode sheet 10H is provided with 9 electrode units 12. The flexible circuit board 11H of the electrode sheet 10H arranges these 9 electrode units 12 in two rows and five columns in the circuit connection, with one row having 5 electrode units 12 and the other row having 4 electrode units 12. The flexible circuit board 11H of the electrode sheet 10H is embedded with 2 grounding lines 18, 5 dual-purpose signal lines 19, 1 grounding trace 171 that is simultaneously connected to the grounding pin of the handshake chip 17 and any grounding line 28, and 1 communication line 172 that is connected to the communication pin of the handshake chip 17. Each grounding wire 18 is used to ground the grounding terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in the corresponding row group. One grounding wire 18 is also used to ground the grounding pin of the handshake chip 17. Each dual-purpose signal line 19 is short-circuited to the dielectric element 15 of each electrode unit 12 in each column group and the signal terminal 14-2 of each temperature sensor 14, for receiving temperature detection signals or transmitting AC signals.

[0110] The two grounding wires 18 of the electrode sheet 10H are the first grounding wire 18-1 and the second grounding wire 18-2. In the two rows of the electrode sheet 10H, the first row group includes electrode units 12-1 to 12-5, and the second row group includes electrode units 12-6 to 12-9. Specifically, the first grounding wire 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-1 to electrode unit 12-5 in the first row group; the second grounding wire 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-6 to electrode unit 12-9 in the second row group, and simultaneously grounds the grounding pin of the handshake chip 17 through the grounding trace 171 connected to the grounding pin of the handshake chip 17. In short, each grounding wire 18 short-circuits and grounds the grounding terminals 14-1 of the temperature sensors 14 of all electrode units 12 in each row group, and one grounding wire 18 also grounds the grounding pin of the handshake chip 17. Instruction manual, pages 25 / 34, 28 CN 121360334 A

[0111] The five dual-purpose signal lines 19 of the electrode sheet 10H include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric element 15 of each of the two electrode units 12, namely electrode unit 12-1 and electrode unit 12-6.Each of the temperature sensors 14 has a signal terminal 14-2; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric element 15 of each of the two electrode units 12 (electrode unit 12-2 and electrode unit 12-7) and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the third dual-purpose signal line 19-3 is simultaneously connected to the dielectric element 15 of each of the two electrode units 12-3 and electrode unit 12-8 and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the fourth dual-purpose signal line 19-4 is simultaneously connected to the dielectric element 15 of each of the two electrode units 12-4 and electrode unit 12-9 and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the fifth dual-purpose signal line 19-5 is connected to the dielectric element 15 of the electrode unit 12-5 and the signal terminal 14-2 of the temperature sensor 14. In short, each dual-purpose signal line 19 shorts in parallel the signal terminals 14-2 of the dielectric elements 15 and temperature sensors 14 of each electrode unit 12 located in the corresponding column group and connects them to the adapter 20.

[0112] The first grounding switch 25-1 and the second grounding switch 25-2 on the adapter 20 are electrically connected to the first grounding wire 18-1 and the second grounding wire 18-2 of the electrode plate 10H respectively through the first connector 40H, and the third grounding switch 25-3 and the fourth grounding switch 25-4 are in an idle and disconnected state. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, the fourth bidirectional switch 26-4, and the fifth bidirectional switch 26-5 on the adapter 20 are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, the fourth dual-purpose signal line 19-4, and the fifth dual-purpose signal line 19-5 respectively via the first connector 40H. A communication transmission line 211 on the adapter 20 is electrically connected to the communication line 172, which is connected to the communication pin of the handshake chip 17 on the electrode plate 10H.

[0113] The tumor electric field therapy system formed by the electrode 10H, the adapter 20, and the electric field generator 30 operates in the same way as the aforementioned tumor electric field therapy system 100. After the electric field generator 30 controls the adapter 20 and the handshake chip 17 of the electrode 10E to complete the handshake communication and confirm that the electrode 10E is connected normally, when all grounding switches 25 are open and the input terminals 2 and sampling terminals 1 of all bidirectional switching switches 26 are closed, all dual-purpose signal lines 19 and AC signal lines 28 are connected, and all electrode units 12 are connected to AC signals. When the sampling terminals 1 and input terminals 2 of all bidirectional switching switches 26 are closed, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 in each row group can be obtained sequentially by turning on each grounding switch 25. Among them, no operation is required for the grounding switches 25 that are in an idle and open state.

[0114] In the preceding embodiments, the number of grounding switches 25 corresponding to each electrode piece 10, 10D, 10E, 10F, and 10H of the adapter 20 is fixed at 4, and the number of bidirectional switching switches 26 corresponding to each electrode piece 10, 10D, 10E, 10F, and 10H is fixed at 5. This allows for the application of various electrode pieces 10, 10D, 10E, 10F, and 10H with different numbers of electrode units 12. However, in some cases, grounding switches 25 and / or bidirectional switching switches 26 may be in an idle or open state, which can complicate the program control. To simplify the control program, specific adapters can be provided corresponding to the number of grounding wires 18 and dual-purpose signal lines 19 of the electrode pieces to avoid the occurrence of grounding switches 25 and / or bidirectional switching switches 26 in an idle or open state, thus facilitating program control. That is, in other embodiments, the number of grounding switches 25 in each group of grounding switches 25 provided on the adapter 20 can be set according to the number of rows of each electrode unit 12 of the corresponding electrode sheet in the circuit connection, or according to the number of grounding wires 18 on the flexible circuit board of the corresponding electrode sheet; the number of bidirectional switching switches 26 in each group of bidirectional switching switches 26 provided on the adapter 20 can be set according to the number of columns of each electrode unit 12 of the corresponding electrode sheet in the circuit connection, or according to the number of dual-purpose signal lines 19 on the flexible circuit board of the corresponding electrode sheet. Preferably, the number of grounding switches 25 in each group of grounding switches 25 of the adapter 20 is equal to the number of rows of each electrode unit 12 of the corresponding electrode sheet in the circuit connection, or equal to the number of grounding wires 18 on the flexible circuit board of the corresponding electrode sheet; the number of bidirectional switching switches 26 in each group of bidirectional switching switches 26 provided on the adapter 20 is equal to the number of columns of each electrode unit 12 of the corresponding electrode sheet in the circuit connection, or equal to the number of dual-purpose signal lines 19 on the flexible circuit board of the corresponding electrode sheet.

[0115] The present invention also provides a temperature detection method for electrode sheet 10 in a tumor electric field therapy system 100. Referring to FIG10, the method includes:

[0116] Step S10: The adapter 20 performs handshake communication with the handshake chip 17 of the electrode sheet 10 to determine the connection status of the corresponding electrode sheet 10.

[0117] Step S20: When the electrode plate 10 and the adapter 20 are connected normally, the adapter 20 is used to configure the switching states of each grounding switch 25 and each bidirectional switching switch 26 corresponding to the electrode plate 10, so that the temperature signals detected by each temperature sensor 14 in each row group are sampled sequentially through the corresponding temperature sampling points.

[0118] The present invention also provides an electrode plate type identification method, wherein the electrode plate type identification is based on the temperature sensors of each row group.This method is performed under the condition that all sensors are normally connected. In addition to the above steps S10 and S20, it also includes:

[0119] Step S30: Identify the type of the corresponding electrode sheet 10 based on the temperature signals detected by all temperature sensors 14 of the corresponding electrode sheet 10.

[0120] The temperature signals detected by all temperature sensors 14 of the corresponding electrode sheet 10 sampled in step S30 are temperature analog signals. Step S30 specifically includes the following steps:

[0121] Step S301: Perform digital-to-analog conversion on all sampled temperature analog signals to obtain several AD sampling values;

[0122] Step S302: Determine the number of electrode units 12 of the corresponding electrode sheet 10 based on the several AD sampling values;

[0123] Step S303: Determine the type of the corresponding electrode sheet 10 based on the number of electrode units 12.

[0124] The present invention also provides a method for judging abnormal electrode temperature. The judgment of abnormal electrode temperature is performed during tumor electric field therapy by applying alternating current signals to each electrode unit of the electrode. In addition to the above steps S10 and S20, the method also includes the following steps:

[0125] Step S40: Judging whether the corresponding electrode 10 has a temperature abnormality based on the temperature signals detected by all temperature sensors of the corresponding electrode.

[0126] Step S40 specifically includes the following steps:

[0127] Step S401: Comparing all sampled temperature signals with a preset temperature threshold;

[0128] Step S402: Judging whether the electrode has a temperature abnormality based on the comparison result.

[0129] The comparison result in step S402 includes temperature signals less than the preset temperature threshold and temperature signals greater than or equal to the preset temperature threshold. The judgment of temperature abnormality is specifically as follows: when there is a temperature signal greater than or equal to the preset temperature threshold among all sampled temperature signals, the electrode temperature is judged to be abnormal; when all sampled temperature signals are less than the preset temperature threshold, the electrode temperature is judged to be normal. The preset temperature threshold is 39℃-44℃, preferably 41℃.

[0130] The present invention also includes an alternating electrical signal adjustment method, which, in addition to steps S10 and S20, further includes: adjusting the alternating electrical signal applied to the corresponding electrode sheet according to the temperature signals detected by all temperature sensors of the sampled corresponding electrode sheet. The adjustment is to adjust the magnitude of the voltage, current or power of the alternating electrical signal.

[0131] Referring to FIG11, the present invention also provides an electric field control method applied to the tumor electric field therapy system 100, which includes the following steps:

[0132] In step 101, the tumor electric field therapy system 100 is connected.

[0133] Specifically, the four electrode sheets 10 are respectively connected to the adapter 20, the adapter 20 is connected to the electric field generator 30, and the electric field generator 30 is connected to a suitable power supply. SpecificationPage 27 / 34 30 CN 121360334 A

[0134] In step 102, it is detected whether the user has issued a command to turn on the electric field. If no command to turn on the electric field is detected, step 102 is repeated; if a command to turn on the electric field is detected, step 103 is entered.

[0135] In step 103, after the electric field generator 30 of the tumor electric field therapy system 100 sends a handshake signal to the electrode 10 connected to the X1 port through the second connector 50, the adapter 20, and the first connector 40 connected to the X1 port, the first controller 22 of the adapter 20 receives the feedback signal from the electrode 10 of the X1 port through the corresponding communication transmission line 211 and determines whether the handshake is successful; if it is unsuccessful, step 105 is entered; if it is successful, step 106 is entered.

[0136] This determination step can occur in the adapter 20 or the electric field generator 30. In this embodiment, the determination step occurs in the adapter 20. Specifically, when the electrode 10 at the X1 port is connected normally, its handshake chip 17 can receive the handshake request signal from the electric field generator 30 and feed back the handshake status to the first controller 22 of the adapter 20. The first controller 22 determines that the handshake is successful. Conversely, when the electrode 10 at the X1 port is connected abnormally, the first controller 22 of the adapter 20 does not receive the feedback signal from its handshake chip 17, and the first controller 22 determines that the handshake has failed.

[0137] In step 105, the tumor electric field therapy system 100 issues an alarm due to the handshake failure and then proceeds to step 101.

[0138] In step 106, after the electric field generator 30 sends a handshake signal to the electrode 10 connected to the X2 port through the second connector 50, the adapter 20, and the first connector 40 connected to the X2 port, the first controller 22 on the adapter 20 receives the feedback signal from the electrode 10 at the X2 port through the corresponding communication transmission line 211 and determines whether the handshake has passed. If it has not passed, proceed to step 105; if it has passed, proceed to step 107.

[0139] This judgment step can occur in the adapter 20 or the electric field generator 30. In this embodiment, the judgment step occurs in the adapter 20. Specifically, when the electrode piece 10 at the X2 port is connected normally, its handshake chip 17 can receive the handshake request signal from the electric field generator 30 and feed back the handshake status to the first controller 22 of the adapter 20. The first controller 22 judges that the handshake is successful. Conversely, when the electrode piece 10 at the X2 port is connected abnormally, the first controller 22 of the adapter 20 does not receive the feedback signal from its handshake chip 17, and the first controller 22 judges that the handshake has failed.

[0140] In step 107, after the electric field generator 30 sends a handshake signal to the electrode piece 10 connected to the Y1 port through the second connector 50, the adapter 20, and the first connector 40 connected to the Y1 port, the first controller 22 on the adapter 20, through the phaseThe communication transmission line 211 receives the feedback signal from the electrode piece 10 at the Y1 port and determines whether the handshake is successful. If it fails, proceed to step 105; if it succeeds, proceed to step 108.

[0141] This determination step can occur in the adapter 20 or the electric field generator 30. In this embodiment, the determination step occurs in the adapter 20. Specifically, when the electrode piece 10 at the Y1 port is connected normally, its handshake chip 17 can receive the handshake request signal from the electric field generator 30 and feed back the handshake status to the first controller 22 of the adapter 20. The first controller 22 determines that the handshake is successful. Conversely, when the electrode piece 10 at the Y1 port is connected abnormally, the first controller 22 of the adapter 20 does not receive the feedback signal from its handshake chip 17, and the first controller 22 determines that the handshake has failed.

[0142] In step 108, after the electric field generator 30 sends a handshake signal to the electrode 10 connected to the Y2 port through the second connector 50, the adapter 20, and the first connector 40 connected to the Y2 port, the first controller 22 on the adapter 20 receives the feedback signal from the electrode 10 at the Y2 port through the corresponding communication transmission line 211, and determines whether the handshake is successful. If it fails, proceed to step 105; if it succeeds, proceed to step 109.

[0143] This determination step can occur in the adapter 20 or the electric field generator 30. In this embodiment, the determination step occurs in the adapter 20. Specifically, when the electrode 10 at the Y1 port is connected normally, its handshake chip 17 can receive the handshake request signal from the electric field generator 30 and feed back the handshake status to the first controller 22 of the adapter 20. The first controller 22 determines that the handshake is successful. Conversely, if the electrode plate 10 at the Y2 port is abnormally connected, the first controller 22 of the adapter 20 will not receive the feedback signal from its handshake chip 17, and the first controller 22 will determine that the handshake has failed. Specification 28 / 34 pages 31 CN 121360334 A

[0144] In the above steps 103, 106, 107, and 108, after receiving the handshake signal from the tumor electric field therapy system 100, the adapter 20 needs to control the corresponding grounding switch 25 and bidirectional switching switch 26 through the first controller 22, so that the grounding switch 25 that is only electrically connected to the handshake chip 17 is closed, all other grounding switches 24 are opened, and the sampling terminal 1 of the corresponding bidirectional switching switch 26 is fully turned on and the input terminal 2 is fully turned off, so that the handshake chip 17 is electrically connected to the grounding pin GND of the adapter 20 through the first connector 40, so that the handshake chip 17 can work normally. If the electric field generator 30 is properly connected to the adapter 20, to each other, and to the electrode plate 10, then the handshake signal emitted by the electric field generator 30 can ultimately reach the handshake chip 17 of the electrode plate 10, and the handshake status of the handshake chip 17 can be fed back to the electric field generator.Device 30. If at least one connection abnormality occurs between the electric field generator 30 and the adapter 20, between the adapters 20 and each other, or between the adapter 20 and the electrode 10, the handshake chip 17 will fail to connect VCC and GND to form a circuit, resulting in the adapter 20 and the electric field generator 30 receiving an empty handshake status signal, and the handshake will fail.

[0145] In step 109, after the electric field generator 30 of the tumor electric field therapy system 100 sets the electric field parameters, it proceeds to step 110. The electric field parameters include the frequency, voltage, current, or power amplitude of the alternating electric signal, etc.

[0146] In step 110, the adapter 20 will send a temperature reading request to the first connector 40 at the Y1 port and the first connector 40 at the Y2 port to collect the temperature detection signals corresponding to the 40 temperature sensors 14 on the electrode 10 at the Y1 port and the electrode 10 at the Y2 port, and then proceed to step 111.

[0147] In step 111, the tumor electric field therapy system 100 determines the type of the electrode pad 10 at port Y1 and port Y2 by collecting the temperature signals, and then proceeds to step 112.

[0148] Specifically, the determination of the type of the electrode pad 10 at port Y1 and port Y2 is based on the number of temperature detection signals of the electrode pad 10 at port Y1 and port Y2, which determines the number of temperature sensors 14 for each electrode pad 10 at port Y1 and port Y2. This determination process can occur in the adapter 20 or the electric field generator 30. In this embodiment, the electrode pad 10 has 20 temperature sensors 14, thus having a total of 40 effective temperature signals.

[0149] In step 112, the tumor electric field therapy system 100 determines whether the temperature signals collected by the adapter 20 are abnormal. If abnormal, it proceeds to step 114. If all temperature signals are normal, it proceeds to step 113.

[0150] In step 113, the electric field generator 30 applies an alternating current signal to a pair of electrode plates 10 connected to ports Y1 and Y2, and simultaneously stops applying an alternating current signal to the pair of electrode plates 10 connected to ports X1 and X2, and proceeds to step 115.

[0151] In step 114, the tumor electric field therapy system 100 alarms due to abnormal temperature signals from the electrode plates 10 connected to port Y1 or port Y2, and then immediately proceeds to step 120.

[0152] In step 115, the adapter 20 sends temperature reading requests to the first connector 40 of port X1 and the first connector 40 of port X2 respectively to collect the temperature signals corresponding to all temperature sensors 14 on the electrode plates 10 of port X1 and port X2, and proceeds to step 116.

[0153] In step 116, the tumor electric field therapy system 100 determines the type of electrode pad 10 at port X1 and port X2 based on the temperature signals and then proceeds to step 117.

[0154] The type of electrode pad 10 at port X1 and port X2 is determined by determining the number of temperature sensors 14 connected to the electrode pad 10 at port X1 and port X2. This determination process can occur in the adapter 20 or the electric field generator 30. In this embodiment, the electrode pad 10 has 20 temperature sensors 14, thus having a total of 40 effective temperature signals.

[0155] In step 117, the tumor electric field therapy system 100 determines whether the temperature signals collected by the adapter 20 are abnormal. If abnormal, it proceeds to step 114. If all 40 effective temperature signals are normal, it proceeds to step 118. Instruction manual, pages 29 / 34, CN 121360334 A

[0156] In step 118, the electric field generator 30 applies an alternating electrical signal to a pair of electrode plates 10 connected to ports X1 and X2, and simultaneously stops applying the alternating electrical signal to a pair of electrode plates 10 connected to ports Y1 and Y2, and proceeds to step 119. The total time for steps 113, 115, 116, 117 to 118 is fixed at 1 second.

[0157] In step 119, the tumor electric field therapy system 100 executes subsequent steps based on whether a user has issued a command to turn off the electric field. If a command to turn off the electric field is detected, it proceeds to step 120; if no command to turn off the electric field is detected, it proceeds to step 121.

[0158] In step 120, the tumor electric field therapy system 100 turns off the electric field and proceeds to step 101. At this time, the electric field therapy ends and waits for the next command to turn on the electric field.

[0159] In step 121, the tumor electric field therapy system 100 determines whether the electric field parameters need to be adjusted based on the current electric field amplitude and the collected temperature signal. If the electric field parameters need to be adjusted, the system proceeds to step 109; if the electric field parameters do not need to be adjusted, the system proceeds to steps 110 to 119 in a loop. The total time for steps 118, 119, 121, 110, 111, 112 to 113 is fixed, which is 1 second in this embodiment. Thus, the tumor electric field therapy system 100 can continuously output alternating electric signals with a period of 2 seconds, applying alternating electric signals in a first direction between a pair of electrodes 10 connected to ports X1 and X2 and alternating electric signals in a second direction between another pair of electrode plates 10 connected to ports Y1 and Y2. Meanwhile, the tumor electric field therapy system 100 can reduce the time interval between turning off the alternating electrical signal applied to a pair of electrode plates 10 connected to ports X1 and X2 and turning on the alternating electrical signal applied to another pair of electrode plates 10 connected to ports Y1 and Y2 to [the time interval is reduced to -1].0s; The time interval between closing the AC signal applied to the other pair of electrode plates 10 connected to the Y1 and Y2 ports and opening the AC signal applied to the other pair of electrode plates 10 connected to the X1 and X2 ports is reduced to 0s, thereby extending the electric field treatment time while ensuring the accuracy of temperature acquisition.

[0160] This application also provides some temperature detection methods and AC signal application control methods, which are described below using electrode plate 10 as an example.

[0161] This application embodiment provides an electrode temperature detection method, applied to the electrode 10 or tumor electric field therapy system 100 described above, as shown in FIG12, which includes the following steps:

[0162] Step 210: under the condition that the electrode is normally connected by a handshake chip, control each bidirectional switching switch 26 electrically connected to each electrode unit 12 of the electrode 10 to disconnect the AC signal applied to the dielectric element 15 of each electrode unit 12 of the electrode 10, and at the same time connect the DC signal applied to the signal terminal 14-2 of the temperature sensor 14 of each electrode unit 12 of the electrode 10;

[0163] Step 220: turn on the grounding switch 25 corresponding to the grounding terminal 14-1 of the temperature sensor 14 of each row group electrode unit 12 of the electrode 10 in a time sequence to obtain the temperature detection signal of the temperature sensor 14 of each electrode unit 12 of the electrode 10.

[0164] Step 210 specifically involves: controlling the bidirectional switching switch 26 electrically connected to each electrode unit 12 of the electrode sheet 10 to switch from the end electrically connected to the AC signal to the end electrically connected to the DC signal, that is, controlling the bidirectional switching switch 26 electrically connected to the electrode sheet 10 to switch from its input terminal 2 to its sampling terminal 1; or

[0165] controlling the bidirectional switching switch 26 electrically connected to each electrode unit 12 of the electrode sheet 10 to switch the dielectric element 15 of each electrode unit 12 of the electrode sheet 10 from the on state to the off state, and at the same time switching the signal terminal 14-2 of the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10 from the off state to the on state.

[0166] The electrode temperature detection method of this application can quickly and accurately obtain the temperature detection signals of all electrode units of the electrode sheet; and can determine whether the temperature sensors of the electrode sheet are faulty, abnormal, or whether the electrode sheet is qualified and needs to be replaced based on the obtained temperature detection signals of all temperature sensors of the electrode sheet; it can also determine whether each electrode unit of the electrode sheet is overheated based on the obtained temperature detection signals of all temperature sensors of the electrode sheet when all temperature sensors of the electrode sheet are normal, and then control the AC signal applied to the electrode sheet or each electrode unit of the electrode sheet; it can also identify the electrode sheet type when the temperature detection signals of all temperature sensors of the electrode sheet are normal.

[0167] Referring to Figure 13, this application embodiment also provides a method for controlling the application of alternating current signals for tumor electric field therapy, which includes the above-mentioned steps 210 and 220, and after step 220, it further includes:

[0168] Step 260: When it is determined that the electrode 10 does not need to be replaced, the alternating current signals applied to each electrode unit 12 of the electrode 10 are controlled or adjusted according to the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of the electrode 10.

[0169] Step 260 further includes controlling or adjusting the alternating current signals applied to each electrode unit 12 of the electrode 10:

[0170] Step 261: When the temperature detection signals of each electrode unit 12 of the electrode 10 do not exceed the preset temperature threshold, the alternating current signals are continued to be applied to each electrode unit 12 of the electrode 10; or

[0171] Step 262: When there is a temperature detection signal in all the temperature detection signals of the electrode unit 12 of the electrode 10 that exceeds the preset temperature threshold, the application of alternating current signals to the electrode unit 12 of the electrode 10 is stopped.

[0172] Step 262, which involves stopping the application of AC signals to the electrode units 12 of the electrode sheet 10, includes stopping the application of AC signals to all electrode units 12 of the electrode sheet 10, stopping the application of AC signals to electrode units 12 in the electrode sheet 10 whose temperature detection signals exceed a preset temperature threshold, and stopping the application of AC signals to all electrode units 12 in the column containing electrode units 12 in the electrode sheet 10 whose temperature detection signals exceed the preset temperature threshold.

[0173] When the application of AC signals to electrode units 12 in the electrode sheet 10 whose temperature detection signals exceed the preset temperature threshold is stopped, the electrode units 12 in the electrode sheet 10 whose temperature detection signals do not exceed the preset temperature threshold continue to be applied AC signals.

[0174] When the application of AC signals to all electrode units 12 in the column containing electrode units 12 in the electrode sheet 10 whose temperature detection signals exceed the preset temperature threshold is stopped, the electrode units 12 in the electrode sheet 10 whose temperature detection signals do not exceed the preset temperature threshold and are in a different column from the electrode units 12 whose temperature detection signals exceed the preset temperature threshold continue to be applied AC signals.

[0175] The process of continuing to apply an AC signal to the electrode plate 10 in step 261 is specifically as follows:

[0176] Step 263: When the temperature detection signal is much lower than the preset temperature threshold, continue to apply an AC signal to each electrode unit 12 of the electrode plate 10 by increasing the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode plate 10, or continue to apply an AC signal to each electrode unit 12 of the electrode plate 10 by keeping the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode plate 10 constant; or

[0177] Step 264: When the temperature detection signal is close to the preset temperature threshold, maintain the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode plate 10 constant.The AC signal is applied to each electrode unit 12 of the electrode sheet 10 in a manner that the voltage or current amplitude of the AC signal on unit 12 remains unchanged, or the AC signal is applied to each electrode unit 12 of the electrode sheet 10 in a manner that the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10 is reduced.

[0178] Referring to Figure 14, this application also provides a signal control method for tumor electric field therapy, used for the above-mentioned electrode sheet 10. The method includes:

[0179] Step 310: Combining control of a set of grounding switches 25 and a set of bidirectional switching switches 26 electrically connected to the corresponding electrode sheet 10 to apply AC signals to each electrode unit 12 of the electrode sheet 10 and executing step 320;

[0180] Step 320: Combining control of a set of grounding switches 25 and a set of bidirectional switching switches 26 electrically connected to the electrode sheet 10 to collect temperature detection signals of each electrode unit of the electrode sheet 10 and executing step 330;

[0181] Step 330: Determining the combination control mode of the set of grounding switches 25 and the set of bidirectional switching switches 26 electrically connected to the electrode sheet 10 according to the collected temperature detection signals and executing step 340;

[0182] Step 340: Control the working state of each electrode unit 12 of the electrode sheet 10 according to the determined combination control method of grounding switch 25 and bidirectional switching switch 26.

[0183] The working state of each electrode unit 12 of the electrode sheet 10 mentioned in step 340 includes one of the following: stopping the application of AC signal and continuing to collect temperature detection signal, and stopping the collection of temperature detection signal and continuing to apply AC signal. Continuing to apply AC signal includes continuing to apply AC signal by increasing the voltage or current amplitude of the currently applied AC signal, continuing to apply AC signal by keeping the voltage or current amplitude of the currently applied AC signal unchanged, and continuing to apply AC signal by decreasing the voltage or current amplitude of the currently applied AC signal.

[0184] The working state of each electrode unit 12 of the electrode sheet 10 is determined by the temperature detection signal it collects. Each electrode unit 12 of the electrode sheet 10 is divided into different regions, and each electrode unit 12 in each region can be cyclically switched between applying AC signal and collecting temperature detection signal by the combination control of grounding switch 25 and bidirectional switching switch 26.

[0185] This application embodiment provides another method for detecting the temperature of an electrode pad in a tumor electric field therapy system. Referring to Figure 15, taking electrode pad 10 as an example, the temperature detection method includes:

[0186] Step 510: Disconnect the input of the AC power signal to electrode pad 10, perform combined control of multiple grounding switches 25 and multiple bidirectional switching switches 26, and acquire the temperature detection signal of the temperature sensor 14 of the electrode pad 10 corresponding to each combination;

[0187] Step 520: Sample and convert the temperature detection signal detected by each temperature sensor 14 in the electrode 10 to obtain a digital temperature signal;

[0188] Step 530: Transmit the digital temperature signal to the electric field generator 30 of the tumor electric field therapy system 100 so that the electric field generator 30 can determine the temperature at the corresponding electrode unit 12 according to the digital temperature signal.

[0189] In step 510, "combined control of multiple grounding switches 25 and multiple bidirectional switching switches 26" specifically includes:

[0190] Step 511: Place all bidirectional switching switches 26 at the sampling end 1 to conduct the electrical connection between the signal end 14-2 of each temperature sensor 14 of all electrode units 12 and the corresponding analog-to-digital converter 23;

[0191] Step 512: Sequentially close one of the multiple grounding switches 25 individually to collect the temperature detection signal detected by the temperature sensor 14 of each electrode unit 12 in the corresponding row group.

[0192] In step 512, closing one of the multiple grounding switches 25 sequentially and time-divisionally enables the detection channel of the analog-to-digital converter 23 to be electrically connected to each temperature sensor 14 in the row group corresponding to the closed grounding switch 25.

[0193] Thus, the temperature detection signals of each temperature sensor 14 in each row group can be obtained sequentially, and then processed by the adapter 20 or the electric field generator 30 to obtain the temperature corresponding to all electrode units 12 on the electrode sheet 10; thereby making the temperature detection of the patient's body surface more comprehensive and accurate.

[0194] For the tumor electric field therapy system 100 of this application embodiment, temperature detection can also be performed on individual electrode units 12 as needed. The specific process for temperature detection of a specific electrode unit 12 of the electrode plate 10 is as follows: Disconnect the AC signal input; place the bidirectional switch 26 corresponding to the column group containing the electrode unit 12 requiring individual temperature measurement at sampling terminal 1; place the remaining bidirectional switches 26 at input terminal 2; simultaneously turn on and ground the grounding switch 25 corresponding to the row group containing the electrode unit 12 requiring individual temperature measurement, and disconnect all other grounding switches 25. Thus, the temperature detection signal from the temperature sensor 14 in the electrode unit 12 requiring individual temperature measurement can be sampled to obtain the temperature of the electrode unit 12. (Instruction manual pages 32 / 34, 35 CN 121360334 A) For example, if the electrode unit 12 requiring individual temperature measurement is electrode unit 12-1, then the first bidirectional switch 26-1 corresponding to electrode unit 12-1 is placed at sampling terminal 1, and the remaining bidirectional switches (second bidirectional switch 26-2, second bidirectional switch 26-3, third bidirectional switch 26-3, and fourth bidirectional switch 26-4) are all placed at input terminal 2; simultaneously, the first grounding switch 25-1 corresponding to electrode unit 12-1 is closed and grounded, and the remaining grounding switches (second...Grounding switch 25-2, third grounding switch 25-3 and fourth grounding switch 25-4 are all disconnected. Therefore, the temperature of electrode unit 12-1 can be detected.

[0195] This application embodiment also provides another method for applying an alternating current signal for tumor electric field therapy, applied to the above-mentioned tumor electric field therapy system, using the tumor electric field therapy system 100 in FIG1 as an example for explanation. Referring to FIG16, the alternating current signal application method includes:

[0196] Step 610: Determine the area of ​​the electrode unit 12 in the electrode sheet 10 where the alternating current signal needs to be applied;

[0197] Step 611: Combine and control multiple grounding switches 25 and multiple bidirectional switching switches 26 electrically connected to the electrode sheet 10 to apply the alternating current signal.

[0198] Step 611, “combining control of multiple grounding switches 25 and multiple bidirectional switching switches 26 electrically connected to electrode plate 10”, specifically includes:

[0199] Step 612: Disconnecting all grounding switches 25 electrically connected to electrode plate 10;

[0200] Step 613: Determining the column group where the electrode unit 12 that needs to be applied AC signal is located, based on the area where the electrode unit 12 that needs to be applied AC signal is located;

[0201] Step 614: Determining the bidirectional switching switch 26 electrically connected to the electrode unit 12 in the column group based on the determined column group where the electrode unit 12 that needs to be applied AC signal is located;

[0202] In step 610: Dividing every four adjacent electrode units 12 in electrode plate 10 into a region, with four electrode units 12 in each region corresponding to a column group, connected to a dual-purpose signal line 19 corresponding to the same bidirectional switching switch 26. In other embodiments, the electrode units 12 may be divided in other ways, which will not be described here.

[0203] Step 615: Control the bidirectional switching switch 26 electrically connected to the electrode unit 12 that needs to be applied with an AC signal to connect the electrode unit 12 that needs to be applied with an AC signal to the AC signal line 28 to apply an AC signal; at the same time, control the remaining bidirectional switching switches 26 to disconnect the electrical connection between each electrode unit 12 in the area where no AC signal needs to be applied and the AC signal line 28, thereby stopping the application of AC signals.

[0204] In step 615, "connecting the electrode unit that needs to be applied with an AC signal to the AC signal line 28 to apply an AC signal and disconnecting the electrical connection between the electrode unit 12 in the area where no AC signal needs to be applied and the AC signal line 28, thereby stopping the application of AC signals" is achieved by placing the bidirectional switching switch 26 electrically connected to the electrode unit 12 in the column group corresponding to the area in the electrode sheet 10 where an AC signal needs to be applied at its input terminal 2, and placing all the bidirectional switching switches 26 electrically connected to the electrode unit 12 in the remaining column groups at the sampling terminal 1.

[0205] When the above methods are applied to electrode plates 10D, 10E, 10F, and 10H in other embodiments, since there are grounding switches 25 and / or bidirectional switching switches 26 in an idle and disconnected state that are not electrically connected to the corresponding electrode plates 10D, 10E, 10F, and 10H on the adapter 20, no related control is required for the corresponding grounding switches 25 and / or bidirectional switching switches 26 in an idle and disconnected state.

[0206] Although the various operations are depicted in the drawings in a specific order, this should not be construed as requiring that these operations must be performed in the specific order shown or in a sequential order, nor should it be construed as requiring that all the operations shown must be performed to obtain the desired result.

[0207] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and not to limit them; although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this application, and they should all be covered within the scope of the claims and the specification of this application. In particular, as long as there is no structural conflict, the various technical features mentioned in the various embodiments can be combined in any way. This application is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims. Instruction manual page 34 / 34, page 37, CN 121360334 A, Figure 1; Instruction manual figure 1 / 13, page 38, CN 121360334 A, Figure 2; Instruction manual figure 2 / 13, page 39, CN 121360334 A, Figure 3; Instruction manual figure 3 / 13, page 40, CN 121360334 A, Figure 4; Instruction manual figure 4 / 13, page 41, CN 121360334 A, Figure 5; Instruction manual figure 5 / 13, page 42, CN 121360334 A, Figure 6; Instruction manual figure 6 / 13, page 43, CN 121360334 A, Figure 7; Instruction manual figure 7 / 13, page 44, CN 121360334 A, Figure 8; Instruction manual figure 8 / 13, page 45, CN 121360334 A, Figure 9; Figure 10; Instruction manual figure 9 / 13, page 46, CN 121360334 A, Figure 11. Instruction manual, figures 10 / 13, page 47, CN 121360334 A, Figures 12 and 13, appendix to the instruction manual.Page 48, Sheet 11 / 13 of FIGS. of CN 121360334 A, FIG. 14, FIG. 15; Page 49, Sheet 12 / 13 of FIGS. of CN 121360334 A, FIG. 16; Page 50, Sheet 13 / 13 of FIGS. of CN 121360334 A {JSHL-26023-HKSPT / 02487567v1} Abstract The invention provides a tumor electric field therapy system which comprises an electrode array and a controller, the electrode array comprises a plurality of electrode units and a handshake chip, and each electrode unit comprises a dielectric element and a temperature sensor having a signal end and a grounding end. The plurality of electrode units are arranged in at least two rows and two columns on the circuit, the grounding ends of the temperature sensors in the same row are in short circuit through the same grounding wire, and the signal ends of the temperature sensors in the same column group are in short circuit through the same dual-purpose signal wire. The dual-purpose signal wire is configured to transmit an alternating current signal to the corresponding dielectric elements in a first mode and to transmit a direct currentsignal to the signal ends of the corresponding temperature sensors or transmit temperature signals detected by the corresponding temperature sensors in a second mode. The controller is configured to communicate with the handshake chip to determine the connection state of the electrode array, and is also configured to combined control the states of the grounding wires and the dual-purpose signal wires when the electrode array are properly connected, so as to enable the dual-purpose signal wire to be switched between transmitting the alternating current electrical signal and transmitting detected temperature signals.

Claims

1. A tumor electric field treatment system, comprising: The system comprises: an electrode sheet comprising a flexible circuit board and a plurality of electrode units and a handshake chip disposed on the flexible circuit board, the electrode unit comprising a dielectric element and a temperature sensor having a signal terminal and a ground terminal, the flexible circuit board being provided with a plurality of ground lines connected to the ground terminals and a plurality of dual-purpose signal lines connected to the signal terminals, and the dielectric element and the signal terminal of the temperature sensor being short-circuited, a plurality of the electrode units being arranged in at least two rows and two columns in circuit, the ground terminals of the temperature sensors in the same row group being short-circuited through the same ground line, and the ground terminals of the temperature sensors in different row groups being connected in parallel through different ground lines respectively; the signal terminals of the temperature sensors in the same column group being short-circuited through the same dual-purpose signal line, and the signal terminals of the temperature sensors in different column groups being connected in parallel through different dual-purpose signal lines respectively; each of the dual-purpose signal lines is configured to transmit an alternating current signal to the dielectric elements of the electrode units in the corresponding column group in a first mode, and transmit a direct current signal to the signal terminals of the temperature sensors of the electrode units in the corresponding column group or transmit a temperature signal detected by the temperature sensors of the electrode units in the corresponding column group in a second mode; and a controller configured to communicate with the handshake chip to determine the connection state of the electrode sheet, and configured to combine the states of the ground lines and the dual-purpose signal lines of the electrode sheet to switch the dual-purpose signal lines between transmitting alternating current signals and temperature detection signals in the case of normal connection of the electrode sheet.

2. The tumor electric field therapy system of claim 1, wherein, The controller is configured to send a handshake signal to the handshake chip and determine whether the electrode sheet is normally connected according to whether feedback from the handshake chip is received.

3. The tumor electric field treatment system of claim 1, wherein, The controller is further configured to control or adjust the alternating current signal transmitted to the dual-purpose signal line according to the temperature detection signals of the electrode units detected.

4. The tumor electric field treatment system of claim 1, wherein, The controller is further configured to determine the working state of each of the electrode units according to the temperature detection signals of the electrode units detected, the working state comprising continuing to apply an alternating current signal or stopping applying an alternating current signal.

5. The tumor electric field treatment system of any one of claims 1-4, wherein, The system has a preset temperature threshold.

6. The tumor electric field therapy system of claim 5, wherein, The controller is further configured to: compare the temperature detection signals of the electrode units obtained with the preset temperature threshold; and control or adjust the alternating current signal transmitted to the dual-purpose signal line according to the comparison result.

7. The tumor electric field treatment system of claim 6, wherein, The controller is configured to: continue to apply an alternating current signal to each of the electrode units of the electrode sheet when the temperature detection signals of each of the electrode units of the electrode sheet obtained do not exceed the preset temperature threshold; or stop applying an alternating current signal to the electrode units of the electrode sheet when there is a temperature detection signal of each of the electrode units of the electrode sheet obtained that exceeds the preset temperature threshold. ​ 8. The tumor electric field treatment system of claim 6, wherein, The comparison result includes not exceeding the preset temperature threshold and exceeding the preset temperature threshold, the not exceeding the preset temperature threshold includes far below the preset temperature threshold and close to the preset temperature threshold, when the temperature detection signal of each electrode unit does not exceed the preset temperature threshold, the controller is further configured to continue transmitting the alternating current signal to the dual-purpose signal line in the following manner: When the temperature detection signal is far below the preset temperature threshold, continue transmitting the alternating current signal to the dual-purpose signal line in the manner of increasing the voltage or current or power amplitude of the alternating current signal currently transmitted to the dual-purpose signal line or keeping the voltage or current, power amplitude of the alternating current signal currently transmitted to the dual-purpose signal line unchanged; Or When the temperature detection signal is close to the preset temperature threshold, continue transmitting the alternating current signal to the dual-purpose signal line in the manner of keeping the voltage or current or power amplitude of the alternating current signal currently transmitted to the dual-purpose signal line unchanged or decreasing the voltage or current or power amplitude of the alternating current signal currently transmitted to the dual-purpose signal line.

9. The tumor electric field treatment system of claim 1, wherein, The controller is further configured to: determine the type of the electrode sheet according to the temperature detection signal of each electrode unit; or determine whether the electrode sheet has temperature abnormality according to the temperature detection signal of each electrode unit; Or determine whether the temperature sensor of the electrode sheet has failure according to the temperature detection signal of each electrode unit; Or determine whether the electrode unit of the electrode sheet has over-temperature according to the temperature detection signal of each electrode unit.

10. The tumor electric field treatment system of claim 9, wherein, The controller is further configured to determine whether the electrode sheet needs to be replaced according to the failure condition of the temperature sensor of the electrode sheet.

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