Polycyclic pyridone derivative and use thereof

Polycyclic pyridinone derivatives are developed to target and inhibit the cap-dependent endonuclease enzyme, addressing the lack of effective inhibitors for diseases like influenza viruses, offering a therapeutic solution.

HK40135185APending Publication Date: 2026-07-17CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO LTD
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Patent Information

Authority / Receiving Office
HK · HK
Patent Type
Applications
Current Assignee / Owner
CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO LTD
Filing Date
2026-05-22
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Current treatments for cap-dependent endonuclease-mediated diseases, such as influenza viruses, lack effective inhibitors that can target the cap-dependent endonuclease enzyme.

Method used

Development of polycyclic pyridinone derivatives that inhibit the cap-dependent endonuclease enzyme, thereby treating such diseases.

Benefits of technology

The polycyclic pyridinone derivatives effectively inhibit the cap-dependent endonuclease enzyme, providing a therapeutic approach for diseases mediated by this enzyme.

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Abstract

The invention provides a polycyclic pyridone derivative as well as a composition and application thereof. The compound disclosed by the invention has an inhibiting effect on influenza virus and can be used for treating cap-dependent endonuclease mediated diseases.
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Description

(19) State Intellectual Property Office (12) Invention Patent Application (10) Application Publication Number (43) Application Publication Date (21) Application Number 202580000334.5 (22) Application Date 2025.03.18 (66) Domestic Priority Data 202410304994.X 2024.03.18 CN (85) PCT International Application Entering National Phase Date 2025.03.18 (86) PCT International Application Application Data PCT / CN2025 / 083049 2025.03.18 (87) PCT International Application Publication Data WO2025 / 195347 ZH 2025.09.25 (71) Applicant Shijiazhuang Zhongqi Pharmaceutical Technology Co., Ltd. Address 050035 No. 896, Zhongshan East Road, High-tech Zone, Shijiazhuang City, Hebei Province (72) Inventors: Zhao Jie, Sun Xiaowei, Gao Yuan, Feng Xiaopeng, Wang Yueqiao, Zhou Yanan, Zhang Xiaolin, Wang Xiaoyan, Guo Hongye, Guo Shulong (74) Patent Agency: China Patent Agency (Hong Kong) Limited 72001 Patent Attorneys: Wang Yingyu, Lin Yibin (51) Int.Cl. C07D 498 / 14 (2006.01) A61K 31 / 5383 (2006.01) A61P 31 / 16 (2006.01) (54) Invention Title: Polycyclic Pyridinone Derivatives and Their Uses (57) Abstract: This invention provides a class of polycyclic pyridinone derivatives, their compositions and uses. The compounds of this invention have inhibitory effects on influenza viruses and can treat cap-dependent endonuclease-mediated diseases. CN 121127476 A 2025.12.12 CN 1 21 12 74 76 A