Adapter and tumor electric field therapy system

Abstract

The invention provides an adapter and a tumor electric field treatment system, the tumor electric field treatment system comprises an electrode plate, the electrode plate is provided with a flexible circuit board, a plurality of electrode units and a handshake chip, and each electrode unit comprises a dielectric element and a temperature sensor with a signal end and a grounding end. The flexible circuit board is provided with multiple paths of grounding wires connected to the grounding ends and multiple paths of dual-purpose signal wires connected to the signal ends, and the dielectric elements of the electrode units are in short circuit with the signal ends. The adapter is provided with a plurality of grounding switches and a plurality of bidirectional change-over switches, each grounding wire is grounded through a corresponding grounding switch, and each dual-purpose signal wire is electrically connected with a corresponding bidirectional change-over switch. The bidirectional change-over switch is provided with an input end connected with an alternating current signal and a sampling end electrically connected with a corresponding detection channel of the analog-to-digital converter. After handshake communication between the adapter and the electrode plate is completed, the state of each grounding switch and each bidirectional change-over switch is configured to enable the electrode plate to apply an alternating current electric signal or perform temperature acquisition.

Description

(19) State Intellectual Property Office (12) Invention Patent Application (10) Application Publication Number (43) Application Publication Date (21) Application Number 202511460414.7 (22) Application Date 2024.10.25 (66) Domestic Priority Data 202311809226.1 2023.12.26 CN PCT / CN2023 / 142515 2023.12.27 CN (62) Divisional Application Data 202411499210.X 2024.10.25 (71) Applicant Jiangsu Hailai Xinchuang Medical Technology Co., Ltd. Address 214100, Jiangsu Province, Wuxi City, Huishan Economic Development Zone, Huishan Avenue, No. 1699, Building 7, 7th Floor, Area A and Area B Applicant: Hangzhou Hailai Xinchuang Medical Technology Co., Ltd. (72) Inventors: Ying Jianjun, Yu Jing, Shen Qichao, Hui Jiajie, Zhang Jun Request: Name not to be disclosed Hu Tao (51) Int.Cl. A61N 1 / 36 (2006.01) A61N 1 / 04 (2006.01) G01K 13 / 00 (2021.01) (54) Invention Title: Adapter and Tumor Electric Field Therapy System (57) Abstract: This application provides an adapter and a tumor electric field therapy system. The tumor electric field therapy system includes an electrode sheet, which is provided with a flexible circuit board, several electrode units, and a handshake chip. The electrode unit includes a dielectric element and a temperature sensor with a signal terminal and a ground terminal. The flexible circuit board is provided with multiple grounding lines connected to each ground terminal and multiple dual-purpose signal lines connected to each signal terminal. The dielectric element of the electrode unit is short-circuited to the signal terminal. The adapter is provided with multiple grounding switches and multiple bidirectional switching switches. Each grounding line is grounded through a corresponding grounding switch, and each dual-purpose signal line is electrically connected to a corresponding bidirectional switching switch. A bidirectional switching switch has an input terminal for receiving an AC signal and a sampling terminal electrically connected to a corresponding detection channel of an analog-to-digital converter. After completing handshake communication with the electrode pad, the adapter applies an AC signal to the electrode pad or performs temperature acquisition by configuring the states of each grounding switch and each bidirectional switching switch. Claims 2 pages, Description 34 pages, Drawings 13 pages, CN 120960639 A 2025.11.18 CN 1 20 96 06 39 A 1. An adapter, characterized in that it is electrically connected to an electrode pad of a tumor electric field therapy system, the electrode pad having a flexible circuit board, a plurality of electrode units disposed on the flexible circuit board, and a handshake chip, the electrode unit including a dielectric element and a temperature sensor having a signal terminal and a ground terminal, the flexible circuit board having multiple grounding lines connected to each of the ground terminals and multiple dual-purpose signal lines connected to each of the signal terminals, and the dielectric element of the electrode unit being short-circuited to the signal terminal, the handshake chip being configured to determine whether the electrode pad is properly connected through handshake communication.Several electrode units are arranged in multiple rows and columns in the circuit. The grounding terminals of each temperature sensor in the same row group are connected to the same grounding line, and the grounding terminals of each temperature sensor in different row groups are connected in parallel through different grounding lines. The signal terminals of each temperature sensor in the same column group are connected to the same dual-purpose signal line, and the signal terminals of each temperature sensor in different column groups are connected in parallel through different dual-purpose signal lines. The adapter is equipped with multiple grounding switches and multiple bidirectional switching switches corresponding to the electrode plates. Each grounding switch grounds each grounding line of the electrode plate one by one, and each bidirectional switch... Each of the dual-purpose signal lines of the electrode plate is electrically connected to the electrode plate in a one-to-one correspondence; the bidirectional switching switch has an input terminal for receiving an AC signal and a sampling terminal electrically connected to a corresponding detection channel of the analog-to-digital converter, and is configured to transmit an AC signal to the dielectric element of the corresponding electrode unit through the dual-purpose signal line electrically connected to it in a first mode when its input terminal is turned on; in a second mode when its sampling terminal is turned on, it transmits a DC signal to the signal terminal of the temperature sensor of the corresponding electrode unit through the dual-purpose signal line electrically connected to it, and transmits the temperature signal detected by the temperature sensor through the dual-purpose signal line electrically connected to it when each of the grounding switches is turned on individually in sequence. 2. The adapter according to claim 1, wherein the adapter is configured to send a handshake signal to the handshake chip and receive a feedback signal from the handshake chip to determine whether it is normally connected to the electrode plate, and when it is normally connected to the electrode plate, the state of each of the grounding switches and each of the bidirectional switching switches is configured to cause the electrode plate to enter a first mode or a second mode. 3. The adapter according to claim 1 or 2, characterized in that the adapter is provided with a first controller, the first controller controlling the power-on of the handshake chip, the on and off of each of the grounding switches, and the on / off of each of the switching switches at its input terminal or sampling terminal. 4. The adapter according to claim 1 or 2, characterized in that the adapter is further provided with an AC signal line corresponding to the electrode plate and a set of analog-to-digital converters having multiple detection channels, the analog-to-digital converters receiving temperature signals detected by each of the temperature sensors in the second mode and converting them into multiple digital signals, the first controller determining the type of the electrode plate based on the multiple digital signals. 5. The adapter according to claim 4, characterized in that the first controller determines whether the electrode plate has a temperature abnormality based on the multiple digital signals. 6. The adapter according to claim 1, characterized in that the flexible circuit board is further provided with a communication line electrically connected to a corresponding part of the handshake chip, and the adapter has a communication transmission line corresponding to the communication line.7. A tumor electric field therapy system, characterized in that it comprises: an electrode sheet, the electrode sheet having a flexible circuit board, a plurality of electrode units disposed on the flexible circuit board, and a handshake chip, the electrode unit including a dielectric element and a temperature sensor having a signal terminal and a ground terminal, the flexible circuit board having multiple grounding lines connected to each of the ground terminals and multiple dual-purpose signal lines connected to each of the signal terminals, and the dielectric element of the electrode unit being short-circuited to the signal terminal, the plurality of electrode units being arranged in multiple rows and columns in the circuit, the ground terminals of each temperature sensor located in the same row group being connected to the same grounding line, and the ground terminals of each temperature sensor located in different row groups being connected in parallel through different grounding lines; the ground terminals of each temperature sensor located in the same column group being connected in parallel through different grounding lines; the ground terminals of each temperature sensor located in different row groups being connected in parallel through different grounding lines; the ground terminals of each temperature sensor located in different column groups ... row groups being connected in parallel through different grounding lines; the ground terminals of each temperature sensor located in different column groups being connected in parallel through different grounding lines; the ground terminals of each temperature sensor located in different row groups being connected in parallel through different grounding lines; the ground terminals of each temperature sensor located in different row groups being connected in parallel through different grounding lines; the ground terminals of each temperature sensor located in different row groups being connected in parallel through different grounding lines; the The signal terminals of each temperature sensor are connected to the same dual-purpose signal line. The signal terminals of each temperature sensor located in different columns are connected in parallel through different dual-purpose signal lines. The handshake chip is configured to determine whether the electrode is properly connected through handshake communication. An adapter with a switching unit is also included. The switching unit has multiple grounding switches and multiple bidirectional switching switches corresponding to the electrode. Each grounding wire of the electrode is grounded through a corresponding grounding switch. Each dual-purpose signal line of the electrode is electrically connected to a corresponding bidirectional switching switch. The bidirectional switching switch has an input terminal connected to an AC signal and a sampling terminal electrically connected to a corresponding detection channel of an analog-to-digital converter. It is configured to transmit AC signals to the dielectric element of the corresponding electrode unit through the dual-purpose signal line electrically connected to it in a first mode where its input terminal is on; transmit DC signals to the signal terminals of the temperature sensors of the corresponding electrode unit through the dual-purpose signal line electrically connected to it in a second mode where its sampling terminal is on; and transmit the temperature signal detected by the corresponding temperature sensor through the dual-purpose signal line electrically connected to it when each grounding switch is sequentially and individually on. 8. The tumor electric field therapy system according to claim 7, wherein the flexible circuit board further comprises a ground trace and a communication line electrically connected to the handshake chip, the handshake chip having a ground pin electrically connected to the ground trace and a communication pin electrically connected to the communication line, the ground trace being electrically connected to one of the ground lines. 9. The tumor electric field therapy system according to claim 8, wherein the adapter comprises an AC signal line electrically connected to the input terminal of each of the bidirectional switching switches and transmitting AC signals, and a communication transmission line corresponding to the communication line. 10. The tumor electric field therapy system according to claim 7, wherein the adapter connects to the handshake chip...The electrode plate sends a handshake signal and receives a feedback signal from the handshake chip. After determining that the electrode plate is normally connected to the adapter, the state of each grounding switch and each bidirectional switching switch is configured to enable the electrode plate to enter the first mode or the second mode. Claims 2 / 2 Page 3 CN 120960639 A Adapter and Tumor Electric Field Therapy System

[0001] This application is a divisional application filed by the applicant on October 25, 2024, with application number CN202411499210.X and invention title "Electrode Plate, Tumor Electric Field Therapy System and Temperature Detection and Signal Control Method". Technical Field

[0002] This application relates to Tumor Treating Fields (TTF) technology, and more particularly to an adapter and a tumor electric field therapy system. Background Art

[0003] Tumor electric field therapy is a method of treating tumors by using low-intensity, medium-to-high-frequency alternating electric fields to prevent the formation of spindle microtubules during mitosis in certain tumor cells, inhibit the separation of intracellular organelles during cell division, and induce apoptosis during mitosis.

[0004] Compared with traditional cancer treatments, TTF has an innovative mechanism of action. Some physiological characteristics of tumor cells, such as their geometry and high-frequency mitosis, make them susceptible to the effects of TTF. TTF disrupts the normal aggregation of tubulin by applying directional forces to polar particles (such as macromolecules and organelles) within the cell. These processes may lead to physical damage to the cell membrane and apoptosis. At the end of mitosis, the morphology of the cleavage groove leads to an uneven distribution of the electric field around it. Under the influence of TTF, the electric field strength at the cleavage groove is significantly enhanced, and charged substances in the cell move towards the cleavage groove, interfering with or even destroying the formation of cell structures, ultimately leading to cell division failure and apoptosis.

[0005] In existing tumor electric field therapy systems, an electric field generator is used to transmit an alternating current signal for tumor electric field therapy to an electrode pad, which then applies an alternating electric field to the tumor site for tumor electric field therapy. When the tumor treatment electric field is applied to the patient's body, heat accumulates at the application site, and the temperature rises accordingly. Therefore, it is necessary to monitor the temperature at the application site. When the temperature is too high, the electric field strength needs to be adjusted in time to avoid the risk of burns to the patient's skin due to excessive temperature.

[0006] The tumor electric field therapy system includes at least one pair of electrode pads, and each electrode pad contains multiple electrode units. Even if the same alternating current signal is applied to each electrode unit, the heat generated on each electrode unit will vary depending on its location. That is, the temperature of each electrode unit on the entire electrode pad will not be completely uniform. This may result in some electrode units on the entire electrode pad having a temperature exceeding the preset temperature, while the temperature of other electrode units is within the preset temperature range.To ensure that tumor electric field therapy has a sufficiently long application time while avoiding low-temperature burns to the patient's skin, it is necessary to individually control the overheated electrode units. However, for existing electrode sheets, individually controlling the electrode units requires setting a conductive trace for each electrode unit in the substrate of the electrode sheet. This increases the number of conductive traces in the electrode sheet substrate, making the electrode sheet difficult to bend, and the cables electrically connected to the electrode sheet are also thickened, increasing the overall weight of the electrode sheet, which is not conducive to the application of the electrode sheet.

[0007] Therefore, it is necessary to provide an adapter and a tumor electric field therapy system. Summary of the Invention

[0008] The purpose of this application is to provide an adapter and a tumor electric field therapy system adapted to an electrode sheet with a handshake chip.

[0009] To achieve the above purpose, this application provides the following technical solution: an adapter, which is compatible with a tumor electric field therapy system. (Page 1 / 34 of the specification 4 CN 120960639 A) The electrode sheets are electrically connected. Each electrode sheet has a flexible circuit board, several electrode units disposed on the flexible circuit board, and a handshake chip. Each electrode unit includes a dielectric element and a temperature sensor with a signal terminal and a ground terminal. The flexible circuit board has multiple grounding lines connected to each ground terminal and multiple dual-purpose signal lines connected to each signal terminal. The dielectric element of each electrode unit is short-circuited to the signal terminal. The handshake chip is configured to determine whether the electrode sheet is properly connected via handshake communication. The several electrode units are arranged in multiple rows and columns in the circuit. The ground terminals of each temperature sensor in the same row group are all connected to the same grounding line, while the ground terminals of each temperature sensor in different row groups are connected in parallel through different grounding lines. The signal terminals of each temperature sensor in the same column group are all connected to the same dual-purpose signal line, while the signal terminals of each temperature sensor in different column groups are connected in parallel through different grounding lines. The dual-purpose signal lines are connected in parallel via different paths; the adapter is provided with multiple grounding switches and multiple bidirectional switching switches corresponding to the electrode plates, each grounding switch grounding each of the grounding wires of the electrode plates one by one, and each bidirectional switching switch electrically connecting to each of the dual-purpose signal lines of the electrode plates one by one; the bidirectional switching switch has an input terminal for receiving AC signals and a sampling terminal electrically connected to a corresponding detection channel of the analog-to-digital converter, and is configured to transmit AC signals to the dielectric element of the corresponding electrode unit through the dual-purpose signal lines electrically connected to it in a first mode when its input terminal is turned on; in a second mode when its sampling terminal is turned on, it transmits DC signals to the signal terminal of the temperature sensor of the corresponding electrode unit through the dual-purpose signal lines electrically connected to it, and transmits the temperature signal detected by the temperature sensor through the dual-purpose signal lines electrically connected to it when each of the grounding switches is turned on individually in sequence.

[0010] Furthermore, the adapter sends a handshake signal to the handshake chip and receives a feedback signal from the handshake chip to determine whether it is normally connected to the electrode plate. When it is normally connected to the electrode plate, the adapter configures the states of each grounding switch and each bidirectional switching switch to enable the electrode plate to enter a first mode or a second mode.

[0011] Furthermore, the adapter is provided with a first controller, which controls the power-on of the handshake chip, the on and off of each grounding switch, and the on / off state of each switching switch's input terminal or its sampling terminal.

[0012] Furthermore, the adapter is also provided with an AC signal line corresponding to the electrode plate and a set of analog-to-digital converters with multiple detection channels. The analog-to-digital converter receives the temperature signals detected by each temperature sensor in the second mode and converts them from analog to digital signals. The first controller determines the type of the electrode plate based on the multiple digital signals.

[0013] Furthermore, the first controller determines whether the electrode plate has a temperature abnormality based on the multiple digital signals.

[0014] Furthermore, the flexible circuit board is also provided with a communication line electrically connected to the corresponding part of the handshake chip, and the adapter has a communication transmission line corresponding to the communication line.

[0015] This application also provides the following technical solution: a tumor electric field therapy system, comprising: an electrode sheet, the electrode sheet having a flexible circuit board, a plurality of electrode units disposed on the flexible circuit board, and a handshake chip, the electrode unit including a dielectric element and a temperature sensor having a signal terminal and a ground terminal, the flexible circuit board having multiple grounding lines connected to each of the ground terminals and multiple dual-purpose signal lines connected to each of the signal terminals, and the dielectric element of the electrode unit being short-circuited to the signal terminal, the plurality of electrode units being arranged in multiple rows and columns in the circuit, the ground terminals of each temperature sensor located in the same row group being connected to the same grounding line, and the ground terminals of each temperature sensor located in different row groups being connected in parallel through different grounding lines; the signal terminals of each temperature sensor located in the same column group being connected to the same dual-purpose signal line, and the signal terminals of each temperature sensor located in different column groups being connected in parallel through different dual-purpose signal lines, the handshake chip being configured to determine the specification page 2 / 34 5 CN 120960639 A through handshake communication. The system checks whether the electrode plates are properly connected; and includes an adapter with a switching unit. The switching unit has multiple grounding switches and multiple bidirectional switching switches corresponding to the electrode plates. Each grounding wire of the electrode plate is grounded through a corresponding grounding switch. Each dual-purpose signal line of the electrode plate is electrically connected to a corresponding bidirectional switching switch. The bidirectional switching switch has an input terminal for receiving an AC signal and a corresponding detection channel for the analog-to-digital converter.The sampling terminal of the device is configured to transmit an AC signal to the dielectric element corresponding to the electrode unit via the dual-purpose signal line electrically connected thereto in a first mode when its input terminal is turned on; and to transmit a DC signal to the signal terminal of the temperature sensor corresponding to the electrode unit via the dual-purpose signal line corresponding thereto in a second mode when its sampling terminal is turned on, and to transmit the temperature signal detected by the temperature sensor corresponding to the temperature unit via the dual-purpose signal line electrically connected thereto when each of the grounding switches is turned on individually in sequence.

[0016] Further, the flexible circuit board is also provided with a ground trace and a communication line electrically connected to the handshake chip. The handshake chip has a ground pin electrically connected to the ground trace and a communication pin electrically connected to the communication line. The ground trace is electrically connected to one of the ground lines.

[0017] Further, the adapter is also provided with an AC signal line electrically connected to the input terminal of each of the bidirectional switching switches and transmitting an AC signal, and a communication transmission line corresponding to the communication line.

[0018] Further, the adapter sends a handshake signal to the handshake chip and receives a feedback signal from the handshake chip. After determining that the electrode plate is normally connected to the adapter, the adapter configures the states of each grounding switch and each bidirectional switching switch to enable the electrode plate to enter the first mode or the second mode.

[0019] The above description is only an overview of the technical solution of this application. In order to better understand the technical means of this application and to implement it according to the contents of the specification, and to make the above and other objects, features and advantages of this application more obvious and understandable, specific embodiments of this application are given below.

[0020] FIG1 is a schematic diagram of a tumor electric field therapy system according to an embodiment of the present application, showing a spatial structure diagram of the electrode sheet of the first embodiment;

[0021] FIG2 is a schematic diagram of the structural layout of a modified embodiment of the electrode sheet of the tumor electric field therapy system shown in FIG1 of the present application;

[0022] FIG3 is a schematic diagram of the circuit connection of the tumor electric field system shown in FIG1 of the present application, showing a circuit connection diagram of the electrode sheet of the first embodiment shown in FIG1 or the electrode sheet of the modified embodiment shown in FIG2 with the adapter shown in FIG1 of the first embodiment;

[0023] FIG4 is a schematic block diagram of the internal structure of the adapter shown in FIG3 of the present application;

[0024] FIG5 is a schematic block diagram of the internal structure of the electric field generator of the tumor electric field therapy system shown in FIG1 of the present application;

[0025] FIG6 is similar to FIG3, and is a schematic diagram of the circuit connection of a tumor electric field therapy system according to a second embodiment of the present application, showing a circuit connection diagram of the electrode sheet of the second embodiment of the tumor electric field therapy system with the adapter shown in FIG3;

[0026] Figure 7, similar to Figure 3, is a circuit connection diagram of the tumor electric field therapy system according to the third embodiment of this application.Figure 3 shows a circuit connection diagram of the electrode sheet and the adapter shown in Figure 3 for the third embodiment of the tumor electric field therapy system of this application;

[0027] Figure 8 is similar to Figure 3, and is a circuit connection diagram of the tumor electric field therapy system of the fourth embodiment of this application. Page 3 / 34 of the specification 6 CN 120960639 A shows a circuit connection diagram of the electrode sheet and the adapter shown in Figure 3 for the fourth embodiment of the tumor electric field therapy system of this application;

[0028] Figure 9 is similar to Figure 3, and is a circuit connection diagram of the tumor electric field therapy system of the fifth embodiment of this application, showing a circuit connection diagram of the electrode sheet and the adapter shown in Figure 3 for the fifth embodiment of the tumor electric field therapy system of this application;

[0029] Figure 10 is a flowchart of a temperature detection method for the tumor electric field therapy system of this application;

[0030] Figure 11 is a flowchart of the tumor electric field therapy system of this application;

[0031] Figure 12 is another flowchart of a temperature detection method for the tumor electric field therapy system of this application;

[0032] Figure 13 is a flowchart of an AC signal application control method for tumor electric field therapy of this application;

[0033] Figure 14 is a flowchart illustrating the signal control method for tumor electric field therapy according to this application;

[0034] Figure 15 is a flowchart illustrating the electrode temperature detection method according to this application;

[0035] Figure 16 is a flowchart illustrating the AC signal application method for tumor electric field therapy according to this application.

[0036] Explanation of reference numerals:

[0037] Tumor electric field therapy system 100, electrode sheets 10, 10', 10D, 10E, 10F, 10H, flexible circuit boards 11, 11D, 11E, 11F, 11H, Connecting parts 111, 111', Wiring parts 112, 112', Bridging parts 113, 113', Main trunk 114, 114', Branch 115, 115', First interval D1, D1', Second interval D2, D2', Electrode unit 12, 12', First cable 13, 13', Temperature sensor 14, Grounding terminal 14-1, Signal terminal 14-2, Dielectric element 15, Diode 16, Handshake chip 17, Grounding trace 171, Communication line 172, Grounding wire 18, First ground Wire 18-1, Second Grounding Wire 18-2, Third Grounding Wire 18-3, Fourth Grounding Wire 18-4, Dual-Purpose Signal Line 19, First Dual-Purpose Signal Line 19-1, Second Dual-Purpose Signal Line 19-2, Third Dual-Purpose Signal Line 19-3, Fourth Dual-Purpose Signal Line 19-4, Fifth Dual-Purpose Signal Line 19-5, Adapter 20, Second Cable 21, First Controller 22, Analog-to-Digital Converter 23, Voltage Divider Resistor 24, Grounding Switch 25, First Grounding Switch 25-1, Second Grounding Switch 25-2, Third Grounding Switch 25-3, Fourth Grounding Wire 18-4, ...Ground switch 25-4, bidirectional switch 26, first bidirectional switch 26-1, second bidirectional switch 26-2, third bidirectional switch 26-3, fourth bidirectional switch 26-4, fifth bidirectional switch 26-5, first communication unit 27, AC signal line 28, first power module 29, communication transmission line 211, electric field generator 30, second power module 31, second controller 32, second communication unit 33, AC signal generator 34, AC signal switch 35, first AC signal switch 35-1, first AC signal switch 35-2, first AC signal switch 35-3, first AC signal switch 35-4, first connector 40, 40D, 40E, 40F, 40H, first plug 41, 41', first socket 42, second connector 50, second plug 51, second socket 52. Detailed Embodiments

[0038] The embodiments of the technical solution of this application will be described in detail below with reference to the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solutions of this application, and are therefore only examples, and should not be used to limit the scope of protection of this application.

[0039] FIG1 is a schematic diagram of a tumor electric field therapy system 100 according to an embodiment of this application. As shown in FIG1, the tumor electric field therapy system 100 includes: at least one pair of electrode plates 10, a converter 20 connected to the electrode plates 10, and an electric field generator 30 connected to the converter 20. The electric field generator 30 generates an alternating current signal for tumor treatment and applies the alternating current signal to the electrode plates 10 through the converter 20, so as to generate a therapeutic electric field between the paired electrode plates 10. The converter 20 is electrically connected between the electrode plates 10 and the electric field generator 30, and is used to transmit the alternating current signal generated by the electric field generator 30 to the electrode plates 10. That is, the electric field generator 30 can generate an alternating current signal, and the generated alternating current signal is transmitted to each electrode plate 10 through the converter 20, so as to generate a therapeutic electric field for treating tumors between the same pair of electrode plates 10. As shown in Figure 1, in this embodiment, the number of electrode plates 10 is four. From a spatial arrangement perspective, each electrode plate 10 includes multiple electrode units 12 arranged in both axially symmetrical and centrally symmetrical configurations, several connecting portions 111 located between adjacent electrode units 12, a bridging portion 113 spanning between adjacent connecting portions 111, a wiring portion 112 connected to the bridging portion 113, and a first cable 13 connected to the wiring portion 112. The bridging portion 113 and the wiring portion 112 are arranged perpendicularly, forming a "T" shape. The bridging portion 113 is spanned between adjacent connecting portions 111. Each electrode unit 12 of the electrode plate 10 is electrically connected to the adapter 20 via a first cable 13 with 10 core wires.

[0040] Each electrode unit 12 has a temperature sensor 14 and a dielectric element 15. The temperature sensor 14 is used to detect the temperature of the area where the electrode unit 12 is applied to the patient's body surface. It can be a thermistor element or a temperature sensor other than a thermistor, and can be located at any position on the electrode unit 12. The dielectric element 15 is used to apply an alternating current signal to the tumor site of the patient. The dielectric element 15 can be a dielectric ceramic sheet or a polymer dielectric layer made of polymer material. In this embodiment, each dielectric element 15 has a through-hole (not labeled) in the middle to accommodate a corresponding temperature sensor 14. Each electrode unit 12 may also include a diode 16 connected in series with the temperature sensor 14 to prevent reverse current flow and prevent detection signals from other electrode units 12 from affecting the temperature sensor 14. The ground terminal 14-1 of the temperature sensor 14 is connected in series with the anode of the diode 16 and grounded through the cathode of the diode 16.

[0041] In the first mode, the electrode unit 12 applies an alternating current signal through the dielectric element 15; in the second mode, it detects or collects the temperature of the patient's body surface to which the corresponding electrode unit 12 is applied through the temperature sensor 14; in the third mode, it stops applying the alternating current signal and stops temperature detection and collection. The first mode, the second mode, and the third mode do not overlap in time periods. That is, the time period during which the dielectric element 15 of the electrode unit 12 applies the alternating current signal is staggered and does not overlap with the time period during which the temperature sensor 14 detects the temperature. The electrode unit 12 can cycle between applying the alternating current signal through its dielectric element 15 and detecting the temperature through its temperature sensor 14, that is, the electrode unit 12 can cycle between the first mode and the second mode. The electrode unit 12 can also cycle between the first mode, the second mode, and the third mode, that is, the electrode unit 12 cycles between applying the alternating current signal through the dielectric element 15, collecting or detecting the temperature through the temperature sensor 14, stopping the application of the alternating current signal, and collecting the temperature.

[0042] Each electrode sheet 10 includes an electrode array (unlabeled) consisting of 20 electrode units 12. The electrode array (unlabeled) also has a flexible circuit board 11 including a connecting portion 111, a wiring portion 112, and a bridging portion 113. The 20 electrode units 12 are distributed in a spaced-out manner in an electrode array (unlabeled) arranged in four rows and six columns. Specifically, the first and last rows each have four electrode units 12, the middle two rows each have six electrode units 12, the four electrode units 12 in the first row are located in the second to fifth columns, the six electrode units 12 in each of the middle two rows are located in the first to sixth columns, and the four electrode units 12 in the last row are also located in the second to fifth columns. Connecting portionThe electrode unit 111 is located only between adjacent electrode units 12 arranged in the column direction in the third and fourth columns, and between adjacent electrode units 12 in the row direction, except for the two electrode units 12 located in the third and fourth columns of each row. That is, the two adjacent electrode units 12 in the third and fourth columns are only connected by the connecting part 111 in the column direction, and are disconnected and not connected by the connecting part 111 in the row direction. The electrode units 12 in the first, second, fifth, and sixth columns are only connected to the electrode units 12 adjacent to them in the row direction by the connecting part 111 arranged in the horizontal direction, and are disconnected in the column direction and between them and the adjacent electrode units 12. In other words, the two adjacent electrode units 12 in the column direction in the first, second, fifth, and sixth columns are all disconnected.

[0043] The electrode units 12 located in the third column and the connecting portions 111 arranged longitudinally between the electrode units 12 in that column, as well as the electrode units 12 located in the fourth column and the connecting portions 111 arranged longitudinally between the electrode units 12 in that column (see specification page 5 / 34, CN 120960639 A), all constitute the main trunk 114 of the electrode array (unnumbered). The connecting portions 111 located on opposite sides of the electrode units 12 in the third and fourth columns and connected to each electrode unit 12 in the third and fourth columns respectively by the connecting portions 111 arranged laterally, and the electrode units 12 connected to the connecting portions 111 arranged laterally, all constitute the branches 115 of the electrode array (unnumbered). That is, in this embodiment, the electrode array (unnumbered) includes two main trunks 114 and a plurality of branches 115 that extend laterally from the two main trunks 114 respectively. Each branch 115 has a free end away from the main trunk 114. The free ends of adjacent branches 115 are disconnected, and the position and distance between adjacent branches 115 can be freely adjusted according to actual usage requirements. Specifically, one main trunk 114 is composed of each electrode unit 12 located in the third column and a connecting portion 111 located between adjacent electrode units 12 in that column and arranged longitudinally. Another main trunk 114 is composed of each electrode unit 12 located in the fourth column and a connecting portion 111 located between adjacent electrode units 12 in that column and arranged longitudinally. The remaining electrode units 12 connected to the main trunk 114 by the transversely arranged connecting portions 111 and the transversely arranged connecting portions 111 are all branches 115.

[0044] Specifically, the branches 115 are: a connecting portion 111 extending laterally to the left from the electrode unit 12 in the third column and first row and located in the first row, and an electrode unit 12 connected to the connecting portion 111 and located in the second column of the first row; two connecting portions 111 extending laterally to the left from the electrode unit 12 in the third column and second row and located in the second row, and located in the second row.Two electrode units 12 in the first column and the second column of the second row; two connecting portions 111 extending laterally to the left from the electrode unit 12 in the third column and the third row and located in the third row; two electrode units 12 in the first column and the second column of the third row; a connecting portion 111 extending laterally to the left from the electrode unit 12 in the third column and the fourth row and located in the fourth row; an electrode unit 12 in the second column of the fourth row; a connecting portion 111 extending laterally to the right from the electrode unit 12 in the first column and the fifth column of the first row and located in the first row; Electrode unit 12; two connecting portions 111 extending laterally to the right from the electrode unit 12 in the second row of the fourth column and located in the second row, and two electrode units 12 located in the fifth and sixth columns of the second row; two connecting portions 111 extending laterally to the right from the electrode unit 12 in the third row of the fourth column and located in the third row, and two electrode units 12 located in the fifth and sixth columns of the third row; a connecting portion 111 extending laterally to the right from the electrode unit 12 in the fourth row and located in the fourth row, and an electrode unit 12 located in the fifth column of the fourth row.

[0045] The electrode array (unlabeled) is divided into a symmetrical left portion including three columns on the left and a right portion including three columns on the right, and the left and right portions are connected only by a bridging portion 113. The left side consists of a main stem 114 located in the third column and several branches 115 extending to the left from the main stem 114. The right side consists of a main stem 114 located in the fourth column and several branches 115 extending to the right from the main stem 115. The two main stems 114 are connected by a bridging portion 113. Specifically, the two main stems 114 are electrically connected by a bridging portion 113 between the connecting portions 111 of the electrode units 12 in the second row of the third column and the connecting portions 111 of the electrode units 12 in the second row of the fourth column and the connecting portions 111 of the electrode units 12 in the third row of the fourth column. The connecting portions 111 of the electrode units 12 in the second row of the third column and the connecting portions 111 of the electrode units 12 in the second row of the third column and the connecting portions 111 of the electrode units 12 in the second row of the fourth column and the connecting portions 113 are generally arranged in an "H" shape. In other embodiments, the bridging portion 113 may also be disposed between an electrode unit 112 located in the third column and an electrode unit 12 located in the fourth column. Optionally, the bridging portion 113 may be disposed between two electrode units 12 located in the third and fourth columns and adjacent in the row direction.

[0046] Each electrode unit 12 can be divided into peripheral electrode units 12 and central electrode units 12 according to its position in the electrode array (unlabeled). The peripheral electrode units 12 include four electrode units 12 located in the first row, two electrode units 12 located at opposite ends of the second row, two electrode units 12 located at opposite ends of the third row, and...Four electrode units 12 are located in the fourth row. The electrode units 12 located in the center include the four electrode units 12 located in the middle of the second row and the four electrode units 12 located in the middle of the third row. Among the multiple electrode units 12 located on the periphery, some adjacent electrode units 12 are connected by a horizontally arranged connecting part 111, while some adjacent electrode units 12 are disconnected. (See page 6 / 34 of the specification, CN 120960639 A). Among the multiple electrode units 12 located on the periphery, the adjacent electrode units 12 connected by the connecting part 111 are partially row-adjacent electrode units 12. Specifically, among the multiple electrode units 12 located on the periphery, the electrode units 12 that are adjacent in the column direction or diagonally adjacent are all disconnected; some row-adjacent electrode units 12 are also disconnected; only some row-adjacent electrode units 12 are connected by a horizontally extending connecting part 111. In the plurality of electrode units 12 located at the center, only two adjacent electrode units 12 in the column direction on the main trunk 114 are connected by a longitudinally arranged connecting part 111, and only two adjacent electrode units 12 in the row direction on the branch 115 are connected by a transversely arranged connecting part 111.

[0047] The electrode array (unlabeled) also has gaps (unlabeled) formed between a plurality of spaced electrode units 12, which allow moisture from the patient's skin to escape, heat exchange between the patient's skin and the outside world, or free breathing of the patient's skin, and also allow the positions and spacing between the branches 115 to be freely adjusted, and also prevent wrinkles when the electrode pads 10 are applied. The gaps (unlabeled) include a first gap D1 located between the two main trunks 114 and a second gap D2 located between the branches 115. The first gap D1 is located between the third column of electrode units 12 and the fourth column of electrode units 12, and the second gap D2 is located between the electrode units 12 in adjacent rows. That is, along the row upwards, the electrode unit 12 located in the third column is disconnected from the adjacent electrode unit 12 located in the fourth column, and no connection part 111 is provided, but the aforementioned first interval D1 is formed; and along the column upwards, only the two adjacent electrode units 12 in the third and fourth columns are connected by the connection part 111, while the two adjacent electrode units 12 in the other four columns are not connected by the connection part 111, but the aforementioned second interval D2 is formed. The setting of the first and second intervals D1 and D2 can also increase the degree of freedom of some electrode units 12, and can also avoid wrinkles when attaching the electrode sheet 10.

[0048] The electrode sheet 10 also includes a handshake chip 17 disposed on the flexible circuit board 11 and used to confirm its connection status. The handshake chip 17 can communicate with the electric field generator 30 through the adapter 20 to determine the connection status between the electrode sheet 10 and the adapter 20. The electric field generator 30 of the tumor electric field therapy system 100 first sends to the handshake chip 17 of the electrode sheet 10 through the adapter 20.The handshake communication signal is received, and the connection status of the electrode pad 10 is determined based on whether feedback from the handshake chip 17 is received. After confirming that the electrode pad 10 is properly connected via the handshake chip 17, the electric field generator 30 of the tumor electric field therapy system 100 applies an AC signal to the dielectric element 15 of the electrode pad 10 or transmits a DC signal to each temperature sensor 14 of the electrode pad 10 to acquire temperature detection signals. The handshake chip 17 can be an EEPROM with encryption function.

[0049] In some other embodiments, the tumor electric field therapy system 100 may have more or fewer electrode pads 10. In some other embodiments, each pair of electrode pads 10 has the same or different number of electrode units 12, and different pairs of electrode pads 10 may also have different numbers of electrode units 12. In some other embodiments, 20 electrode units 12 may also be arranged in other ways. Of course, in some other embodiments, the electrode pad 10 may also have other numbers of electrode units 12. In some other embodiments, 20 electrode units 12 may also be arranged in other ways, as shown in electrode pad 10' in FIG2. Of course, in other embodiments, the electrode sheet 10 may also have other numbers of electrode units 12. In summary, the implementation of this application is not limited by the number and arrangement of the electrode units 12 of the electrode sheet 10.

[0050] The electrode sheet 10' shown in FIG2 is a modified embodiment of the electrode sheet 10 shown in FIG1. ​​The spatial structure of the electrode sheet 10' is the same as that of the electrode sheet 10, and it also includes a plurality of electrode units 12' arranged at intervals, a plurality of connecting portions 111' located between two adjacent electrode units 12', a wiring portion 112' connected to the bridging portion 113', a first cable 13' connected to the wiring portion 112', a first interval D1 formed between the third column electrode units 12' and the fourth column electrode units 12', and a second interval D2' formed between the electrode units 12' in adjacent rows; the connecting portion 111', the wiring portion 112', and the bridging portion 113' also constitute a flexible circuit board (not labeled), and the electrode sheet 10' is also plugged into the adapter 20 through the first plug 41' of the first cable 13' with 10 core wires. The only difference is that the two adjacent electrode units 12' in the fourth column are arranged in a disconnected state. The electrodes are not connected by vertically arranged connecting parts 111', but adjacent electrode units 12' in the fifth column are connected by vertically arranged connecting parts 111'. Each electrode unit 12' in the fourth column is connected to the adjacent electrode unit 12' in the fifth column by horizontally arranged connecting parts 111'. A bridging part 113' connects the two electrode units 12' located in the third row and third column of the third row and the four columns of the third row. A main branch 114' is formed by the electrode units 12' located in the third column.The connecting portion 111' between the electrode units 12' in the column is formed by the electrode unit 12' in the fifth column and the connecting portion 111' between the electrode units 12' in the column. The structure of the left side of the left three columns of the electrode array (unlabeled) is exactly the same as the structure of the left side of the electrode array (unlabeled) shown in FIG1. ​​Only the right side is different because the position of the main stem 114' changes from the fourth column to the fifth column, resulting in the branch 115' in the right side extending to the left and right sides of the corresponding electrode unit 12' in the main stem 114'.

[0051] FIG3 is a schematic diagram of the circuit connection between the electrode sheet 10 of the first embodiment of the tumor electric field therapy system 100 shown in FIG1 or the electrode sheet 10' of the transformation embodiment shown in FIG2 and the adapter 20 of the first embodiment. It is worth noting that the arrangement of electrode units 12 shown in Figure 3 is to more clearly illustrate the electrical connection between an electrode sheet 10 and the adapter 20. The arrangement of electrode units 12 shown in Figure 3 does not represent the spatial arrangement of electrode units 12. The circuit connection is described below using the electrode sheet 10 in the first embodiment as an example.

[0052] Referring to Figures 1 and 3, in this embodiment, each electrode sheet 10 is provided with 20 electrode units 12. The 20 electrode units 12 are arranged in the order of 1 to 20 in the circuit connection and are divided into four row groups and five column groups, that is, the 20 electrode units 12 are arranged in four rows and five columns in the circuit connection. The temperature sensor 14 of each electrode unit 12 includes a ground terminal 14-1 and a signal terminal 14-2. The dielectric element 15 and the temperature sensor 14 of each electrode unit 12 are soldered on the flexible circuit board 11, and the dielectric element 15 is short-circuited to the signal terminal 14-2 of the corresponding temperature sensor 14. Since the electrode units 12 are arranged in a four-row, five-column configuration in the circuit connection, and each electrode unit includes a corresponding dielectric element 15 and a corresponding temperature sensor 14, the multiple temperature sensors 14 are also arranged in a four-row, five-column configuration in the circuit connection, and the multiple dielectric elements 15 are also arranged in a four-row, five-column configuration in the circuit connection. It should be noted that this arrangement is for clearer illustration of the electrical connection between the electrode pad 10 and the adapter 20, and does not represent the spatial arrangement of the electrode units 12. The spatial structure may be a roughly array-like structure as shown in Figure 1, or other structures, such as petal-shaped or scattering structures, and can be regular or irregular. The dielectric element 15 is configured to apply an alternating electric field to the patient's tumor site. The temperature sensor 14 is configured to detect the temperature of the patient's body surface in contact with the electrode pad 10 and output a temperature detection signal to the adapter 20.

[0053] The flexible circuit board 11 is embedded with multiple conductive traces 171, 172, 18, and 19.19 includes multiple grounding lines 18, multiple dual-purpose signal lines 19, one grounding trace 171, and one communication line 172. One end of the grounding trace 171 is connected to the grounding pin of the handshake chip 17, and the other end is connected to any one of the grounding lines 18. The grounding pin of the handshake chip 17 is connected to the grounding trace 171, and its communication pin is electrically connected to the communication line 172. That is, the handshake chip 17 is grounded through the grounding line 18 connected to the grounding trace 171, and communicates with external devices through the communication line 172. Specifically, the handshake chip 17 is grounded through the grounding trace 171 connected to its grounding pin and one of the grounding lines 18, and sequentially through the communication line 172 of the flexible circuit board 11, a wire electrically connected to the first cable 13 and the communication line 172, an adapter 20 electrically connected to the first cable 13, and an electric field generator 30 electrically connected to the adapter 20 to achieve communication connection between itself and the electric field generator 30, thereby determining the connection status of the electrode sheet 10. The first cable 13 has multi-core wires (not shown) that are electrically connected one-to-one with the communication line 172, the multi-path grounding line 18, and the multi-path dual-purpose signal line 19 of the flexible circuit board 11. The total number of communication lines 172, grounding lines 18, and dual-purpose signal lines 19 embedded in the flexible circuit board 11 does not exceed 10. Therefore, the number of wires in the first cable 13 does not exceed 11.

[0054] The number of conductive lines electrically connected to the grounding line 18 in the tumor electric field therapy system 100 is related to the number of rows M of the electrode unit 12, which can be greater than or equal to the number of rows of the electrode unit 12, where M is a positive integer. The number of conductive lines electrically connected to the dual-purpose signal line 19 in the tumor electric field therapy system 100 is related to the number of columns N of the electrode unit 12, which can be greater than or equal to the number of columns of the electrode unit 12, where N is a positive integer. In this embodiment, the number of grounding wires 18 is equal to the number of rows M of electrode units 12; the number of dual-purpose signal lines 19 is equal to the number of columns N of electrode units 12. The number of lines L embedded in the flexible circuit board 11 is equal to the sum of the number of grounding wires 18 and the number of dual-purpose signal lines 19 plus 2, that is, L=M+N+2. The number of conductors of the first cable 13 is M+N+1.

[0055] The multiple dual-purpose signal lines 19 of the flexible circuit board 11 are respectively arranged in a one-to-one correspondence with the multiple columns of the electrode units 12, and are configured to transmit the AC signal generated by the electric field generator 30 to the dielectric element 15 in each electrode unit 12 in the corresponding column. That is, the dielectric elements 15 located in the same column are all short-circuited through the same dual-purpose signal line 19 of the flexible circuit board 11, and the dielectric elements 15 located in different columns are respectively connected in parallel through different dual-purpose signal lines 19 of the flexible circuit board 11. The dual-purpose signal lines 19 of the flexible circuit board 11 are electrically connected to the corresponding wires in the first cable 13, and then...The adapter 20 is electrically connected to the electric field generator 30. That is, the dual-purpose signal line 19 of the flexible circuit board 11 receives the AC signal generated by the electric field generator 30 through the first cable 13 and the adapter 20.

[0056] The multiple grounding lines 18 are respectively set to correspond one-to-one with the multiple rows of the electrode unit 12. The multiple grounding lines 18 are used to short-circuit and ground the temperature sensor 14 of each electrode unit 12 in each row group in sequence. That is, the grounding terminals 14-1 of the multiple temperature sensors 14 located in the same row group are all short-circuited through the same grounding line 18 of the flexible circuit board 11, and the grounding terminals 14-1 of the temperature sensors 14 located in different row groups are respectively connected in parallel through different grounding lines 18 of the flexible circuit board 11. During the time period of temperature detection or in the second mode, only one of the multiple grounding lines 18 is conducting at the same time, and the rest are disconnected.

[0057] Each of the multiple dual-purpose signal lines 19 is also configured to transmit a DC signal to the temperature sensor 14 in each electrode unit 12 in the corresponding column group to collect and transmit the detected temperature signal. The signal terminals 14-2 of the multiple temperature sensors 14 located in different column groups are connected in parallel through different dual-purpose signal lines 19 of the flexible circuit board 11. The signal terminals 14-2 of the multiple temperature sensors 14 located in the same column group are all shorted to the same dual-purpose signal line 19 of the flexible circuit board 11, and the shorting point serves as a temperature sampling point. Specifically, each dual-purpose signal line 19 is configured to short-connect the signal terminal 14-2 of the temperature sensor 14 of at most one electrode unit 12 in each row group to an external device for receiving the detection signal. The signal terminals 14-2 of the temperature sensors 14 connected to each of the multiple dual-purpose signal lines 19 are different to avoid the dual-purpose signal line 19 from outputting duplicate signals in the future. That is, when the number of electrode units 12 in a row group is the same as the number of dual-purpose signal lines 19, each dual-purpose signal line 19 is electrically connected to the signal terminal 14-2 of the temperature sensor 14 of a different electrode unit 12 in that row group; when the number of electrode units 12 in a row group is less than the number of dual-purpose signal lines 19, at least one dual-purpose signal line 19 is not electrically connected to the signal terminal 14-2 of the temperature sensor 14 of the electrode unit 12, and the remaining dual-purpose signal lines 19 are electrically connected to the signal terminal 14-2 of the temperature sensor 14 of a different electrode unit 12 in that row group. In this embodiment, the external device for receiving the detection signal is an adapter 20. The dual-purpose signal lines 19 of the flexible circuit board 11 receive DC signals from the adapter 20 or the electric field generator 30 through the first cable 13, and transmit the collected or detected temperature signals to the adapter 20, and then to the electric field generator 30 via the adapter 20.

[0058] In this embodiment, when a temperature sensor 14 is configured in each electrode unit 12 for temperature detection, the...The above circuit design reduces the number of wires in the first cable 13, avoiding the cable becoming thicker and harder, thus increasing the difficulty of cable fixation; at the same time, it avoids the increased number of wires in the first cable 13 affecting the adhesion effect between the electrode sheet 10 and the corresponding body surface of the patient's tumor site.

[0059] The flexible circuit board 11 has a total of 9 lines, including the grounding wire 18 and the dual-purpose signal line 19. In this embodiment, the flexible circuit board 11 has 4 lines for the grounding wire 18 and 5 lines for the dual-purpose signal line 19. Specifically, the electrode sheet 10 in this embodiment includes 4 grounding wires 18, each grounding wire 18 is used to ground the grounding terminal 14-1 of the temperature sensor 14 in the same row group. The 4 grounding wires 18 of the electrode sheet 10 are the first grounding wire 18-1, the second grounding wire 18-2, the third grounding wire 18-3 and the fourth grounding wire 18-4. In the four rows of electrode plates 10, the first row includes electrode units 12-1 to 12-5, the second row includes electrode units 12-6 to 12-10, the third row includes electrode units 12-11 to 12-15, and the fourth row includes electrode units 12-16 to 12-20. Specifically, the first grounding wire 18-1 is used to ground electrode units 12-1 to 12-5 in the first row; the second grounding wire 18-2 is used to ground electrode units 12-6 to 12-10 in the second row; the third grounding wire 18-3 is used to ground electrode units 12-11 to 12-15 in the third row; and the fourth grounding wire 18-4 is used to ground electrode units 12-16 to 12-20 in the fourth row. It should be noted that these grounding wires 18 can be selectively closed or opened, which can be achieved by connecting each grounding wire 18 in series with a switch, as will be described in detail below. The above-mentioned "grounding the electrode unit 12" can refer to grounding the grounding terminal 14-1 of the temperature sensor 14 in the electrode unit 12, or it can refer to the diode 16 being connected in series with the temperature sensor 14 of the same electrode unit 12 and grounded together. In short, each grounding wire 18 short-circuits and grounds the grounding terminals 14-1 of the temperature sensors 14 of all electrode units 12 in the corresponding row group. The fourth grounding wire 18-4 is also short-circuited with the grounding trace 171 connected to the grounding pin of the handshake chip 17.

[0060] Continuing to refer to FIG3, the electrode sheet 10 of this embodiment also includes 5 dual-purpose signal lines 19, one end of each dual-purpose signal line 19 is connected to all electrode units 12 in each column group, and the other end is connected to the adapter 20 for receiving temperature detection signals and transmitting AC signals. That is, for each row group, each dual-purpose signal line 19 canTo avoid duplicate signals being output by the dual-purpose signal line 19, one can choose to connect to one of the electrode units 12 or not connect to any of the electrode units 12 in the row group. Specifically, the five dual-purpose signal lines 19 of the electrode sheet 10 include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric element 15 of each of the four electrode units 12 (electrode units 12-1, 12-6, 12-11, and 12-16) and the signal terminal 14-2 of their respective temperature sensors 14; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the electrode units 12-2, 12-7, 12-8, 12-9 ... 12. Each of the four electrode units 12 (12-17) has its own dielectric element 15 and its own temperature sensor 14 signal terminal 14-2. One end of the third dual-purpose signal line 19-3 is connected to the dielectric element 15 and its own temperature sensor 14 signal terminal 14-2 of each of the four electrode units 12 (12-3, 12-8, 12-13, 12-18). One end of the fourth dual-purpose signal line 19-4 is connected to the dielectric element 15 and its own temperature sensor 14 signal terminal 14-2 of each of the four electrode units 12 (12-4, 12-9, 12-14, 12-19). One end of the fifth dual-purpose signal line 19-5 is connected to the dielectric element 15 and its own temperature sensor 14 signal terminal 14-2 of each of the four electrode units 12 (12-5, 12-10, 12-15, 12-20). In short, each dual-purpose signal line 19 shorts in parallel the signal terminals 14-2 of each dielectric element 15 of each electrode unit 12 located in the same column group and is used to connect to an external device. It should be noted that these dual-purpose signal lines 19 can selectively transmit AC signals or receive temperature detection signals. This can be achieved by connecting each dual-purpose signal line 19 in series with a bidirectional switching switch 26 and cooperating with the closing or opening of the grounding line 18, which will be described in detail below.

[0061] In other embodiments, the grounding line 18 and the dual-purpose signal line 19 embedded in the flexible circuit board 11 may have other numbers depending on the circuit arrangement and number of electrode units 12 in different electrode sheets, which will be specifically described in subsequent embodiments.

[0062] In this embodiment, the grounding pin of the handshake chip 17 used by the electrode sheet 10 to confirm its connection status is connected to the fourth grounding line 18-4 through the grounding trace 171 embedded on the flexible circuit board 11. The first cable 13 has 10 core wires, as shown on page 10 / 34 of the instruction manual, 13 CN.120960639 A 4-way grounding line 18, 5-way dual-purpose signal line 19, and 1-way communication line 172. The specific connection relationship and working principle of the handshake chip 17 will be described in detail below.

[0063] The tumor electric field therapy system 100 of this embodiment includes at least one pair of the above-mentioned electrode plates 10, an adapter 20 electrically connected to the electrode plates 10, and an electric field generator 30 electrically connected to the adapter 20. The adapter 20 is connected between the electrode plates 10 and the electric field generator 30. When the electric field generator 30 or the adapter 20 controls the grounding pin of the handshake chip 17 to be grounded, the electric field generator 30 sends a handshake communication signal to the handshake chip 17 of the electrode plate 10 via the adapter 20 and the communication line 172 of the electrode plate 10 to determine the connection status of the electrode plate 10. When the electrode plates 10 are properly connected, the electric field generator 30 provides AC signals to the dielectric elements 15 in the multiple electrode units 12 of the electrode plate 10 via the adapter 20 and the dual-purpose signal line 19 of the electrode plate 10, or provides DC signals to the temperature sensors 14 in the multiple electrode units 12 of the electrode plate 10 via the adapter 20 and the dual-purpose signal line 19 of the electrode plate 10, and is used to receive temperature detection signals output by the temperature sensors 14 in the multiple electrode units 12. The adapter 20 is configured to send a handshake communication signal to the communication line 172 of the electrode plate 10 according to the communication command of the electric field generator 30, and is configured to transmit the AC signals generated by the electric field generator 30 to the dual-purpose signal line 19 of the electrode plate 10, and is also configured to transmit DC signals to the dual-purpose signal line 19 of the electrode plate and receive temperature detection signals output by the multiple dual-purpose signal line 19 of the electrode plate 10.

[0064] Referring again to Figures 3 and 4, the adapter 20 includes: a first controller 22, a multi-channel communication transmission line 211 electrically connected to the first controller 22, multiple sets of analog-to-digital converters 23 connected to the first controller 22, multiple sets of voltage-reducing resistors 24 and multiple sets of grounding switches 25 corresponding to each set of analog-to-digital converters 23, multiple sets of bidirectional switching switches 26 corresponding to each set of analog-to-digital converters 23, a first communication unit 27, AC signal lines 28 corresponding to each set of bidirectional switching switches 26, and a first power module 29 connected to the first communication unit 27, the first controller 22, and the multiple sets of analog-to-digital converters 23. The first power module 29 provides DC power VCC to each electronic component of the adapter 20. The adapter 20 also includes multiple circuit lines (unlabeled). The multiple circuit lines (unlabeled) are electrically connected, one-to-one, to the multiple grounding lines 18, multiple dual-purpose signal lines 19, and communication lines 172 within the flexible circuit board 11 of the corresponding electrode 10 via the first cable 13 of the respective electrode 10. The multiple circuit lines (unlabeled) include multiple lines that transmit AC signals to the corresponding electrode 10 and connect to the corresponding electrode 10.The flexible circuit board 11 contains multiple dual-purpose signal lines 19, all electrically connected to AC signal lines 28; multiple circuit lines (unlabeled) electrically connected one-to-one with the multiple dual-purpose signal lines 19 in the flexible circuit board 11 of the corresponding electrode 10, used to power each temperature sensor 14 of the electrode 10 or transmit the temperature detection signal of the electrode 10; multiple circuit lines (unlabeled) electrically connected one-to-one with the multiple grounding lines 18 in the flexible circuit board 11 of the corresponding electrode 10; and multiple communication transmission lines 211 electrically connected one-to-one with the multiple communication lines 172 in the flexible circuit board 11 of the corresponding electrode 10. All communication transmission lines 211 are connected to the first controller 22. Each communication transmission line 211 is connected to the communication line 172 of the flexible circuit board 11 through the corresponding first connector 40, and the first controller 22 and the handshake chip 17 are electrically connected to the handshake chip 17 by shorting the grounding pin of the handshake chip 17 of the closed flexible circuit board 11 through the grounding switch 25 corresponding to the grounding line 18. This enables the handshake chip 17 to obtain power and enable the data communication function.

[0065] The number P of the circuit lines P that the adapter 20 is electrically connected to one electrode piece 10 is equal to the sum of the number of rows M and the number of columns N of the electrode unit 12 of the electrode piece 10 plus 2; the number H of the circuit lines H that the adapter 20 is electrically connected to X electrode pieces 10 is equal to X times the number of circuit lines that it is electrically connected to a single electrode piece 10. The number of grounding switches 25, the number of bidirectional switching switches 26, the number of AC lines 28, and the number of communication transmission lines 211 are all related to the number of electrode pieces 10. The number of grounding switches 25, the number of bidirectional switching switches 26, the number of AC lines 28, and the number of communication transmission lines 211 are all the same; and not less than the number of electrode pieces 10. Preferably, the number of grounding switches 25, the number of bidirectional switching switches 26, the number of AC lines 28, and the number of communication transmission lines 211 are all the same as the number of electrode pieces 10. The following is a detailed description of the electrical connection between an electrode piece 10 and the adapter 20, using only an electrode with 20 electrode units 12 as an example (page 11 / 34, CN 120960639 A).

[0066] Each group of grounding switches 25 is provided with multiple grounding switches 25. The multiple grounding switches 25 are respectively connected to the adapter 20 and electrically connected to the circuit lines (unlabeled) corresponding one-to-one with the multiple grounding lines 18 of a corresponding electrode piece 10, and are configured to control the conduction or disconnection of the multiple grounding lines 18. The circuit lines (unlabeled) of the multiple grounding wires 18, each electrically connected to the electrode sheet 10, are grounded at the end near the grounding switch 25. The number of grounding switches 25 in each group is related to the number of grounding wires 18 on the corresponding flexible circuit board 11 of the electrode sheet 10; in this embodiment, both are equal.As shown in Figure 3, in this embodiment, each group of grounding switches 25 includes a first grounding switch 25-1, a second grounding switch 25-2, a third grounding switch 25-3, and a fourth grounding switch 25-4. Each group of multiple grounding switches 25 controls the closing or opening of the corresponding grounding wire 18 of a corresponding electrode piece 10. Specifically, the first grounding switch 25-1 controls the closing or opening of the first grounding wire 18-1 of the corresponding electrode piece 10, and can then cooperate with the corresponding group of bidirectional switching switches 26 to control the energization and de-energization of the temperature sensors 14 of the five electrode units 12 (electrode units 12-1 to 12-5) in the first row of the electrode piece 10. The second grounding switch 25-2 is used to control the opening or closing of the second grounding wire 18-2 of the electrode plate 10, and can then cooperate with the corresponding set of bidirectional switching switches 26 to control the energization and de-energization of the temperature sensors 14 of the five electrode units 12 from electrode unit 12-6 to electrode unit 12-10 in the second row of the electrode plate 10; the third grounding switch 25-3 is used to control the opening or closing of the third grounding wire 18-3 of the electrode plate 10, and can then cooperate with the corresponding set of bidirectional switching switches 26 to control the energization and de-energization of the temperature sensors 14 of the five electrode units 12 from electrode unit 12-6 to electrode unit 12-10 in the third row of the electrode plate 10. The temperature sensors 14 of each of the five electrode units 12 in units 12-15 are energized and de-energized; the fourth grounding switch 25-4 is used to control the closing or opening of the fourth grounding wire 18-4 of the electrode plate 10, and then judges the connection status of the electrode plate 10 by the electrical connection status of the communication line 172 of the handshake chip 17 and the communication transmission line 211 of the adapter 20, and can also cooperate with the corresponding set of bidirectional switching switches 26 to control the energization and de-energization of the temperature sensors 14 of each of the five electrode units 12 in the fourth row group of the electrode plate 10 from electrode unit 12-16 to electrode unit 12-20. The grounding switch 25 can be a mechanical switch, such as a relay. The grounding switch 25 can also be an electronic switch, and each grounding switch 25 can be opened and closed by the first controller 22 of the adapter 20.

[0067] In this embodiment, multiple sets of grounding switches 25 are all electronic switches. The first controller 22 is communicatively connected to multiple sets of grounding switches 25, and is used to sequentially and cyclically control the opening and closing states of multiple grounding switches 25 in each set of grounding switches 25, thereby sequentially and individually activating each grounding wire 18 in the multiple grounding wires 18 of the corresponding electrode 10 and cooperating with the switching of the corresponding bidirectional switching switch 26, so as to sequentially and time-divisionally collect the temperature of the patient's body surface detected by all temperature sensors 14 on the electrode 10. The number of grounding switches 25 in each set is greater than or equal to the number of grounding wires 18 of the flexible circuit board 11 of the corresponding electrode 10. In this embodiment, the number of grounding switches 25 in each set is the same as the number of grounding wires 18 of the corresponding electrode 10.

[0068] Each set of bidirectional switching switches 26 is provided with multiple bidirectional switching switches 26, and the multiple bidirectional switching switches 26 in each setEach bidirectional switch 26 is connected to the adapter 20 and electrically connected to the circuit line (unlabeled) corresponding to the multi-purpose signal line 19 of the corresponding electrode 10. The number of bidirectional switches 26 in each group is related to the number of dual-purpose signal lines 19 on the flexible circuit board 11 of the corresponding electrode 10, and is greater than or equal to the number of dual-purpose signal lines 19 on the flexible circuit board 11 of the corresponding electrode 10. In the embodiment shown in Figure 3, the two are equal. Each bidirectional switch 26 has a sampling terminal 1 and an input terminal 2. The sampling terminals 1 of multiple bidirectional switches 26 in the same group are electrically connected to the corresponding detection channels in the multiple detection channels of the corresponding group of analog-to-digital converters 23, and each detection channel corresponds to a corresponding temperature sampling point. The input terminal 2 of each bidirectional switch 26 in the same group is electrically connected to the same AC signal line 28. Each bidirectional switch 26 is configured to control the multiplexed signal line 19 to connect to the corresponding AC signal line 28 to transmit AC signals or to connect to the corresponding detection channel of the corresponding group of analog-to-digital converters 23 to receive the temperature detection signal output by the temperature sensor 14.

[0069] As shown in FIG3, taking an electrode plate 10 electrically connected to the adapter 20 as an example, in this embodiment with 20 electrode units 12, the multiple bidirectional switches 26 are respectively a first bidirectional switch 26-1, a second bidirectional switch 26-2, a third bidirectional switch 26-3, a fourth bidirectional switch 26-4, and a fifth bidirectional switch 26-5. The multiple bidirectional switches 26 in the same group each control the switching of a corresponding dual-purpose signal line 19 among the multiplexed signal lines 19 of the same electrode plate 10 between transmitting AC signals and transmitting temperature detection signals.

[0070] Specifically, the first bidirectional switching switch 26-1 is used to control the switching of the first dual-purpose signal line 19-1 of the corresponding electrode pad 10 between transmitting AC signals and transmitting temperature detection signals, thereby controlling the switching between the conduction of each dielectric element 15 of the electrode units 12-1, 12-6, 12-11, and 12-16 in the first column of the electrode pad 10 and the conduction of the signal terminal 14-2 of each temperature sensor 14 in the first column of the electrode units 12-1, 12-6, 12-11, and 12-16, and cooperating with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4 so that the first column of electrode units 12-1, 12-6, 12-11, and 12-16 transmits AC signals to the patient or outputs these electrodes to the corresponding analog-to-digital converter 23.The temperature sensor 14 of unit 12 collects the temperature detection signal; the second bidirectional switch 26-2 is used to control the switching of the second dual-purpose signal line 19-2 of the corresponding electrode 10 between transmitting AC signals and transmitting temperature detection signals, thereby controlling the switching between the conduction of each dielectric element 15 of the electrode units 12-2, 12-7, 12-12, and 12-17 in the second column of the electrode 10 and the conduction of the signal terminal 14-2 of each temperature sensor 14 of the electrode units 12-2, 12-7, 12-12, and 12-17 in the second column of the electrode 10, and cooperating with the corresponding grounding switches 25-1, 25-2, 25-3, and 25-4, so that the second column of electrode units 12-2, 12-7, 12-12, and 12-17 transmits AC signals to the patient or to the corresponding analog-to-digital converter 23. The temperature sensors 14 of the electrode units 12 are output to collect temperature detection signals. A third bidirectional switch 26-3 controls the switching of the third dual-purpose signal line 19-3 of the corresponding electrode pad 10 between transmitting AC signals and transmitting temperature detection signals. This controls the switching between the conduction of the dielectric elements 15 of each electrode unit 12-3, 12-8, 12-13, and 12-18 in the third column of the electrode pad 10 and the conduction of the signal terminals 14-2 of each temperature sensor 14 of each electrode unit 12-3, 12-8, 12-13, and 12-18, and coordinates with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4, so that the third column of electrode units 12-3, 12-8, 12-13, and 12-18 transmits AC signals to the patient or outputs these signals to the corresponding analog-to-digital converter 23. The temperature sensor 14 of electrode unit 12 collects the temperature detection signal; the fourth bidirectional switching switch 26-4 is used to control the switching of the fourth dual-purpose signal line 19-4 of the corresponding electrode plate 10 between transmitting AC signal and transmitting temperature detection signal, thereby controlling the switching between the conduction of each dielectric element 15 of electrode unit 12-4, electrode unit 12-9, electrode unit 12-14, and electrode unit 12-19 in the fourth column of electrode plate 10 and the conduction of the signal terminal 14-2 of each temperature sensor 14 of electrode unit 12-4, electrode unit 12-9, electrode unit 12-14, and electrode unit 12-19 in the fourth column of electrode plate 10, and cooperating with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4 so that the fourth column of electrode unit 12-4, electrode unit 12-9, electrode unit 12-14, and electrode unit 12-19 can transmit AC signal and transmit temperature detection signal.Units 12-19 transmit AC signals to the patient or output temperature detection signals collected by the temperature sensors 14 of the electrode units 12 to the corresponding analog-to-digital converter 23; the fifth bidirectional switch 26-5 is used to control the switching of the fifth dual-purpose signal line 19-5 of the corresponding electrode pad 10 between transmitting AC signals and transmitting temperature detection signals, thereby controlling the switching between the conduction of each dielectric element 15 of the electrode units 12-5, 12-10, 12-15, and 12-20 in the fifth column of the electrode pad 10 and the conduction of the signal terminals 14-2 of each temperature sensor 14 of the electrode units 12-5, 12-10, 12-15, and 12-20 in the fifth column of the electrode pad 10, and the corresponding first grounding switch 25-1 and second grounding switch. (Instruction manual page 13 / 34, 16 CN 120960639 A) The third grounding switch 25-2, the fourth grounding switch 25-3, and the fifth grounding switch 25-4 cooperate to enable the fifth column of electrode units 12-5, 12-10, 12-15, and 12-20 to transmit AC signals to the patient or output temperature detection signals collected by the temperature sensors 14 of the electrode units 12 to the corresponding analog-to-digital converter 23.

[0071] When each group of grounding switches 25 is open and the input terminal 2 of each group of bidirectional switching switches 26 is on and the sampling terminal 1 is off, AC signals can be transmitted to the dielectric elements 15 of each electrode unit 12 of the corresponding electrode sheet 10. When the sampling terminal 1 of each group of bidirectional switching switches 26 is on and the input terminal 2 is off, it can cooperate with each grounding switch 25 in the corresponding group of grounding switches 25 to transmit the temperature detection signals collected by the temperature sensors 14 of each electrode unit 12 on the electrode sheet 10 in a time-division manner. The bidirectional switching switches 26 can be mechanical switches, such as relays. The bidirectional switching switch 26 can also be an electronic switch. The switching between the sampling terminal 1 and the input terminal 2 of each bidirectional switching switch 26 can be controlled by the first controller 22 of the adapter 20.

[0072] In this embodiment, all the bidirectional switching switches 26 are electronic switches. The first controller 22 is communicatively connected to the multiple bidirectional switching switches 26 and is used to control the multiple bidirectional switching switches 26 in each group to switch between their respective sampling terminal 1 and input terminal 2, and cooperate with the closing or opening of the corresponding grounding switch 25 to continuously monitor the temperature of the patient's body surface detected by all the temperature sensors 14 on the electrode pad 10 or to transmit AC signals to the patient. In this embodiment, the multiple grounding switches 25 and the multiple bidirectional switching switches 26 together form a switching unit (unlabeled).

[0073] In this embodiment, each group of analog-to-digital converters 23 is electrically connected to the sampling terminal 1 of the multiple bidirectional switching switches 26 in the corresponding group through multiple circuit lines (unlabeled) in the adapter 20, and is configured to useThe system receives temperature detection signals transmitted via the multi-channel dual-purpose signal lines 19 of the corresponding electrode sheet 10 and converts these signals from analog to digital. Each group of analog-to-digital converters 23 includes multiple detection channels A, B, C, D, and E. Each detection channel A, B, C, D, and E is connected to a corresponding dual-purpose signal line 19 via a corresponding bidirectional switch 26. The number of detection channels in each group of analog-to-digital converters 23 is related to the number of bidirectional switches 26 in the corresponding group. The number of detection channels in each group of analog-to-digital converters 23 is related to the number of columns of the electrode units 12 of the corresponding electrode sheet 10. Specifically, the number of detection channels in each group of analog-to-digital converters 23 is equal to the number of bidirectional switches 26 in its corresponding group of bidirectional switches 26, and is not less than the number of columns of the electrode units 12 of the corresponding electrode sheet 10. As shown in Figure 3, each group of analog-to-digital converters 23 contains a total of 5 detection channels A, B, C, D, and E, which are respectively the first detection channel A, the second detection channel B, the third detection channel C, the fourth detection channel D, and the fifth detection channel E. The first detection channel A is connected to the first dual-purpose signal line 19-1 via the sampling terminal 1 of the first bidirectional switch 26-1; the second detection channel B is connected to the second dual-purpose signal line 19-2 via the sampling terminal 1 of the second bidirectional switch 26-2; the third detection channel C is connected to the third dual-purpose signal line 19-3 via the sampling terminal 1 of the third bidirectional switch 26-3; the fourth detection channel D is connected to the fourth dual-purpose signal line 19-4 via the sampling terminal 1 of the fourth bidirectional switch 26-4; and the fifth detection channel E is connected to the fifth dual-purpose signal line 19-5 via the sampling terminal 1 of the fifth bidirectional switch 26-5. Each detection channel A, B, C, D, and E is used to receive the temperature detection signal collected by the temperature sensor 14 of the electrode unit 12 connected to the corresponding dual-purpose signal line 19. In addition, each detection channel A, B, C, D, and E is connected to the first power module 29, which provides the detection voltage to the corresponding detection channel A, B, C, D, and E, via a corresponding voltage divider resistor 24 in the adapter 20. The first power module 29 provides a DC signal.

[0074] In this embodiment, the first communication unit 27 is configured to acquire digital signals output by multiple sets of analog-to-digital converters 23 and send the digital signals to the electric field generator 30. The electric field generator 30 is also configured to control and adjust the voltage, current, or power of the AC signal provided to the multiple electrode units 12 of the electrode sheet 10 according to the received digital signals. For example, when any of the received digital signals exceeds a preset threshold, it indicates that the temperature detected by at least one temperature sensor 14 in the electrode sheet 10 at the corresponding dielectric element 15 on the surface of the human body exceeds the preset threshold temperature (e.g., 41°C, 42°C, etc.). At this time, the voltage, current, or power of the AC signal output by the electric field generator 30 can be appropriately reduced. (Page 14 / 34 of the specification)17 CN 120960639 A rate, to avoid the electrode unit 12 of the electrode pad 10 from getting too hot when an AC signal is applied, causing low-temperature burns to the patient's skin. The above-mentioned preset threshold temperature and preset threshold can be determined according to the human safety threshold. The first communication unit 27 is controlled by the first controller 22 and serially transmits digital signals converted by multiple sets of analog-to-digital converters 23. In this embodiment, the preset temperature threshold can be a value within 36℃-45℃.

[0075] One end of each of the multiple communication transmission lines 211 embedded in the adapter 20 is connected to the first controller 22, and the other end is electrically connected to the communication line 172 electrically connected to the communication pin of the handshake chip 17 of the corresponding electrode pad 10 through the corresponding wire of the corresponding first cable 13. The grounding pin GND of the adapter 22 is also connected to the grounding pin of the handshake chip 17 of the corresponding electrode 10 through a wire electrically connected to the corresponding grounding switch 25, a grounding wire 18 connected to both the wire of the corresponding first cable 13 and the grounding trace 171, and a grounding trace 171 shorted to the grounding wire 18. That is, the first controller 22 controls the grounding switch 25 corresponding to the grounding wire 18-4 shorted to the grounding pin of the handshake chip 17 of the electrode 10 to close, and sends a handshake communication signal to the communication line 172 of the electrode 17 through the communication transmission line 211. The first controller 22 determines whether the connection between the electrode 10 and the adapter 20 is normal based on whether it can receive feedback from the communication line 172 of the electrode 10.

[0076] Referring to Figures 4 and 5, in this embodiment, the first power module 29 is electrically connected to the second power module 31 of the electric field generator 30 and is configured to supply power to the first controller 22, multiple analog-to-digital converters 23, and the first communication unit 27 of the adapter 20. Each electrode 10 is connected to the adapter 20 by a first connector 40, which is adapted to connect the corresponding electrode 10 to the adapter 20. As shown in Figure 1, the first connector 40 includes a first plug 41 located at the end of the first cable 13 away from the electrode 10 and a first socket 42 located on the adapter 20. The first plug 41 and the first socket 42 are press-type spring connectors, that is, the first connector 40 connects the adapter 20 and the electrode 10 by means of a connector. Each first cable 13 has five wires electrically connected to bidirectional changeover switches 26-1, 26-2, 26-3, 26-4, and 26-5 in the corresponding group of bidirectional changeover switches 26, four wires electrically connected to grounding switches 25-1, 25-2, 25-3, and 25-4 in the corresponding group of grounding switches 25, and one communication line 172 and adapter 20 that are simultaneously electrically connected to the electrode plate 10.The communication transmission line 211 is a conductor. That is, each first connector 40 is electrically connected to a corresponding set of bidirectional switching switches 26, a corresponding set of grounding switches 25, and a corresponding communication transmission line 211 connected to the first controller 22 through 10 conductors; and is connected to the electric field generator 30 through a corresponding AC signal line 28 of the adapter 20.

[0077] A second connector 50 is provided between the adapter 20 and the electric field generator 30. The second connector 50 is adapted to connect the electric field generator 30 to the adapter 20. The adapter 20 also includes a second cable 21 connected to the second connector 50. The second connector 50 includes a second plug 51 located at the end of the second cable 21 away from the first controller 22 and a second socket 52 located on the electric field generator 30. The second plug 51 and the second socket 52 are press-type spring connectors, that is, the second connector 50 connects the adapter 20 and the electric field generator 30 by means of a connector. Each first connector 40, such as X1, Y1, X2, and Y2, is connected to the second connector 50 via a corresponding AC signal line 28. The first connectors 40, such as X1, Y1, X2, and Y2, are respectively connected to a corresponding set of grounding switches 25, a corresponding set of analog-to-digital converters 23, and a corresponding communication transmission line 211. Each first connector 40 is connected to the second connector 50 and the corresponding set of analog-to-digital converters 23 via a corresponding set of bidirectional switching switches 26. Taking four electrode plates 10 as an example, the second cable 21 has eight wires, including four wires 1 to 4 that are electrically connected to the corresponding AC signal lines 28 for transmitting AC signals, one wire 5 that is electrically connected to the data receiving line RX of the first communication unit 27, one wire 6 that is electrically connected to the data transmitting line TX of the first communication unit 27, one wire 7 that is electrically connected to the VCC power line of the first power module 29, and one wire 8 that is electrically connected to the GND line of the first power module 29. The second connector 50 is connected to the first communication unit 27 via a data receiving line RX and a data transmitting line TX. The VCC pin of the second connector 50 is connected to the VCC power line of the first power module 29, and the GND pin of the second connector 50 is connected to and grounded to the GND line of the first power module 29. The VCC pin of the second connector 50 is also connected to the corresponding set of voltage-reducing resistors 24 and the corresponding set of analog-to-digital converters 23 via the VCC power line of the first power module 29.

[0078] Referring to FIG5, the electric field generator 30 includes: a second power module 31, a second controller 32, an AC signal generator 34, a second communication unit 33, and a set of AC signal switches 35. The VCC pin of the second connector 50 is also connected to the second power module 31 via the VCC power line of the first power module 29.The VCC power supply line is electrically connected, and the GND pin of the second connector 50 is grounded through the GND line of the second power module 31. The second power module 31 is also connected to and supplies power to the second controller 32 and the AC signal generator 34, respectively. The second communication unit 33 is electrically connected to the wire 5 of the second connector 50 through its data receiving line RX and to the wire 6 of the second connector 50 through its data transmitting line TX, thereby realizing information exchange between the electric field generator 30 and the adapter 20. The second controller 32 is also electrically connected to the second communication unit 33, the AC signal generator 34, and a set of AC signal switches 35. The second controller 32 is configured to control the opening and closing of each AC signal switch 35 in the set of AC signal switches 35 and adjust the relevant parameters of the AC signal applied by the AC signal generator 34 according to the relevant digital signals received from the adapter 20 by the second communication unit 33. The relevant parameters of the AC signal include the voltage, current, and power of the AC signal. The AC signal generator 34 is electrically connected to a set of AC signal switches 35 and several wires 1, 2, 3, and 4 of the second connector 50 for transmitting AC signals. The set of AC signal switches 35 includes multiple AC signal switches 35, each corresponding to a specific electrode piece 10. Each AC signal switch 35 is electrically connected to a corresponding wire 1, 2, 3, or 4 of the second connector 50 via an AC signal connector 36, and is also electrically connected to the corresponding electrode piece 10 via corresponding wires 1, 2, 3, and 4 of the second connector 50, to transmit an AC signal to each electrode piece 10. The AC signal generator 34 is electrically connected to the set of AC signal switches 35 via a set of AC signal connectors 36.

[0079] Specifically, the number of AC signal switches 35 in the electric field generator 30 is related to the number of electrode pieces 10. In this embodiment, the number of AC signal switches 35 is equal to the number of electrode pieces 10, and both are four. The AC signal switch 35 includes a first AC signal switch 35-1, a second AC signal switch 35-2, a third AC signal switch 35-3, and a fourth AC signal switch 35-4, each electrically connected to wires 1 to 4 of the second connector 50 respectively. One end of the first AC signal switch 35-1 is electrically connected to the AC signal generator 34 via the first AC signal wiring 36 of the electric field generator 30. The other end is electrically connected to the corresponding AC signal transmission wire 1 in the second connector 50 via the first AC signal wiring 36-1, and to the AC signal line 28 located at port X1 of the adapter 20 via wire 1 of the second connector 50. The AC signal line 28 located at port X1 of the adapter 20 is electrically connected to the first connector 40. The first connector 40 located at port X1 of the adapter 20 is electrically connected to the corresponding electrode plate 10 to control the generation of AC signals.Whether device 34 supplies AC signal to electrode 10 electrically connected to port X1 of adapter 20; one end of the second AC signal switch 35-2 is electrically connected to AC signal generator 34 through the second AC signal wiring 36 of electric field generator 30, and the other end is electrically connected to the corresponding AC signal transmission wire 2 in the second connector 50 through the second AC signal wiring 36-2, and electrically connected to the AC signal line 28 of adapter 20 located at port Y1 through the wire 2 of the second connector 50; the AC signal line 28 of adapter 20 located at port Y1 is electrically connected to the first connector 40; the first connector 40 located at port Y1 of adapter 20 is connected to the corresponding electrode 10. Electrical connection is provided to control whether the AC signal generator 34 supplies an AC signal to the electrode 10 electrically connected to port Y1 of the adapter 20; one end of the third AC signal switch 35-3 is electrically connected to the AC signal generator 34 through the third AC signal wiring 36-3 of the electric field generator 30, and the other end is connected to the corresponding AC signal transmission wire 3 in the second connector 50 through the AC signal wiring 36-3. The AC signal generator 34 is electrically connected to the AC signal line 28 at port X2 of the adapter 20 via the wire 3 of the second connector 50. The AC signal line 28 at port X2 of the adapter 20 is electrically connected to the first connector 40. The first connector 40 at port X2 of the adapter 20 is electrically connected to the corresponding electrode 10 to control whether the AC signal generator 34 transmits an AC signal to the electrode 10 electrically connected to port X2 of the adapter 20. One end of the fourth AC signal switch 35-4 is electrically connected to the AC signal generator 34 via the fourth AC signal wiring 36-4 of the electric field generator 30, and the other end is electrically connected to the corresponding AC signal transmission wire 4 in the second connector 50 via the fourth AC signal wiring 36-4. The second end is also electrically connected to the adapter 20 at port Y2 via the wire 4 of the second connector 50. (Instruction manual 16 / 34 pages 19 CN 120960639 A) The AC signal line 28 at port Y2 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at port Y2 of the adapter 20 is electrically connected to the corresponding electrode plate 10, so as to control whether the AC signal generator 34 transmits AC signal to the electrode plate 10 electrically connected to port Y1 of the adapter 20.

[0080] The working principle of the handshake chip 17 is described in detail below. The handshake chip 17 can store electrical energy when the communication line 172 transmits a high level through an external energy storage element (not shown), and release energy when the communication line 172 transmits a low level, so that the handshake chip 17 obtains enough power and works normally. Optionally, the energy storage element is a capacitor. In this way, the handshake chip 17 only needs an extra core wire for communication to work normally. The handshake chip 17 is suitable for use with external devices such as the electric field generator 30 or the adapter.The device 20 performs handshake communication to determine the connection status of each pair of electrode plates 10. After the handshake communication is completed between the handshake chip 17 and the adapter 20 and / or the electric field generator 30, the states of the bidirectional switching switch 26 and the grounding switch 25 can be combined to enable the electrode plate 10 to apply an AC signal or perform temperature acquisition. When the electrode plate 10 needs to perform temperature acquisition or temperature measurement, all the bidirectional switching switches 26 on the flexible circuit board 11 of the electrode plate 10 are located at the sampling end 1. The electric field generator 30 or the adapter 20 can sequentially close each grounding switch 25 so that the analog temperature signal of the corresponding temperature sensor 14 in each row group is simultaneously sampled by the corresponding temperature sampling point. The analog temperature signal detected by each sampled temperature sensor 14 can also be converted into a value that can characterize the type of electrode plate 10 if the electrode plate 10 is qualified, or it can be used to characterize whether the electrode plate 10 has a temperature abnormality.

[0081] Specifically, when the first controller 22 of the adapter 20 receives the handshake signal sent by the electric field generator 30, it controls the corresponding grounding switch 25 connected to the grounding pin of the handshake chip 17 to close, so that the handshake chip 17 is powered on and sends the handshake signal to the handshake chip 17. The handshake chip 17 sends a feedback signal, and the first controller 22 on the adapter 20 sends the feedback signal of the handshake chip 17 to the second controller 32 of the electric field generator 30 through the second connector 50. The second controller 32 determines whether the corresponding first controller 22 and the handshake chip 17 have completed handshake communication according to the feedback signal of the handshake chip 17, and after the handshake communication is completed, it configures the state of each grounding switch 25 and each bidirectional switching switch 26 in the switch unit (unlabeled) on the adapter 20 to transmit AC signals to the dielectric elements of each electrode unit 12 of the electrode sheet 10 or to measure the temperature through the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10. When the electrode 10 is in the temperature acquisition state, the electric field generator 30 controls each bidirectional switching switch 26 of the adapter 20 through its second controller 32 to make each bidirectional switching switch 26 be in its respective acquisition terminal 1, and sequentially close each grounding switch 25, so that each detection channel of the corresponding analog-to-digital converter 23 acquires the temperature detection signal of each temperature sensor 14 in a row, and performs analog-to-digital conversion on the acquired several temperature analog signals to obtain several AD sampling values, which correspond to digital temperature. The first controller 22 can also send several AD sampling values ​​to the electric field generator 30 through the adapter 20, so that if the electrode 10 is qualified, the electric field generator 30 can identify the type of the corresponding electrode 10 according to several AD sampling values, and / or, in the process of transmitting alternating electrical signals to the corresponding electrode 10, determine whether the corresponding electrode 10 has a temperature abnormality according to several AD sampling values.

[0082] The working principle of the tumor electric field therapy system 100 of this embodiment will be described in detail below with reference to Figures 3 to 5.

[0083] The second controller 32 of the electric field generator 30 controls the grounding switch 25-4 corresponding to the fourth grounding line 18-4 connected to the handshake chip 17 of the electrode 10 to be in a closed state through the first controller 22 of the adapter 20. It also sends a handshake signal to the communication line 172 of the electrode 10 through the first controller 22, and determines the connection status between the electrode 10 and the adapter 20 based on whether feedback from the handshake chip 17 is received. If the electric field generator 30 receives a feedback signal from the electrode 10, it indicates that the connection between the electrode 10 and the adapter 20 is normal; then, an AC signal can be applied to the electrode 10, or a temperature detection signal can be acquired through the temperature sensor 14 of the electrode 10. If the electric field generator 30 does not receive a feedback signal from the electrode 10, it indicates that the connection between the electrode 10 and the adapter 20 is abnormal, and the second controller 32 of the electric field generator 30 issues a connection abnormality warning to alert the operator. After the operator handles the issue, the second controller 32 continues to control the adapter 20. (See page 17 / 34 of the instruction manual, CN 120960639 A). The first controller 22 sends a handshake communication signal to the handshake chip 17 of the electrode 10, repeating the above-mentioned operation of judging the connection status of the electrode 10 until the electrode 10 and the adapter 20 are properly connected.

[0084] When the electrode plate 10 is connected normally and the temperature of each electrode unit 12 of a certain electrode plate 10 needs to be detected, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls the sampling terminal 1 of each of the multiple bidirectional switching switches 26 electrically connected to the electrode plate 10 to be turned on and the input terminal 2 to be turned off, so as to disconnect the AC signal applied to the electrode plate 10; at the same time, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls each of the grounding switches 25 electrically connected to the electrode plate 10 to be turned on in sequence. At this time, the temperature detection signal collected by each temperature sensor 14 of each electrode unit 12 in each row of the electrode plate 10 can be collected in sequence in time through the multiple detection channels A, B, C, D, E of the set of analog-to-digital converters 23 corresponding to the electrode plate 10. Each detection channel A, B, C, D, and E of each group of analog-to-digital converters 23 simultaneously acquires only the temperature detection signal from the temperature sensor 14 of the corresponding electrode unit 12 in the same row of electrode plates 10. This temperature detection signal can be characterized by a voltage value. Of the four grounding switches 25 corresponding to the electrode plate 10, only one can be on at any given time, while the other three are off. All five bidirectional switching switches 26 of the group of bidirectional switching switches 26 corresponding to the group of analog-to-digital converters 23 are switched to their respective sampling terminals 1 to enable the dual-purpose signal lines 19 of the electrode plate 10 to operate simultaneously.The corresponding detection channels A, B, C, D, and E of the corresponding analog-to-digital converter 23 are electrically connected and turned on one by one. With this configuration, the group of analog-to-digital converters 23 can collect the voltage values ​​of all temperature sensors 14 of each electrode unit 12 in the same row group that are shorted by a grounding wire 18 corresponding to the turned-on grounding switch 25.

[0085] Specifically, when the first grounding switch 25-1 is closed, the second grounding switch 25-2, the third grounding switch 25-3, and the fourth grounding switch 25-4 are all open, and the first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, the third bidirectional switching switch 26-3, the fourth bidirectional switching switch 26-4, and the fifth bidirectional switching switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of the electrode units 12-1 to 12-5 of the first row group are energized, and the electrode units 12-6 of the other row groups are energized. When the temperature sensors 14 of electrode units 12-20 are de-energized, the signal terminals 14-2 of the temperature sensors 14 of electrode units 12-1, 12-6, 12-11, and 12-16 are shorted on the first detection channel A of the analog-to-digital converter 23. Since only the ground terminal 14-1 of the temperature sensor 14 of electrode unit 12-1 is connected to ground, while the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-6, 12-11, and 12-16 are disconnected, and each electrode unit 12 is provided with a diode 16 connected in series with the temperature sensor 14, the other temperature sensors 14 in the first row will not affect the resistance value of the temperature sensor 14 of electrode unit 12-1. Therefore, only the temperature sensor 14 of electrode unit 12-1 is effectively operating on the first detection channel A of the analog-to-digital converter 23, and the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 of electrode unit 12-1. Similarly, the voltage value collected on the second detection channel B in this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-2. The voltage value collected on the third detection channel C in this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-3. The voltage value collected on the fourth detection channel D in this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-4. The voltage value collected on the fifth detection channel E in this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-5.

[0086] When the second grounding switch 25-2 is closed, the first grounding switch 25-1, the third grounding switch 25-3 and the fourth grounding switch 25-4 are all open, and the first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, the third bidirectional switching switch 26-3, the fourth bidirectional switching switch 26-4 and the fifth bidirectional switching switch 26-5 are all switched to their respective sampling terminals 1, the second rowThe temperature sensors 14 of electrode units 12-6 to 12-10 in the group are powered on, while the temperature sensors 14 of electrode units 12-1 to 12-5 and electrode units 12-11 to 12-20 in the remaining rows are de-powered. The signal terminals 14-2 of the temperature sensors 14 of electrode units 12-1, 12-6, 12-11, and 12-16 in the first detection channel A of the analog-to-digital converter 23 are shorted. Since only the ground terminal 14-1 of the temperature sensor 14 of electrode unit 12-6 is connected... The circuit is grounded, while the grounding terminals 14-1 of the temperature sensors 14 of electrode units 12-1, 12-11, and 12-16 are all disconnected. Each electrode unit 12 has a diode 16 connected in series with the temperature sensor 14. The other temperature sensors 14 in the second row do not affect the resistance of the temperature sensor 14 in electrode unit 12-6. Therefore, only the temperature sensor 14 of electrode unit 12-6 is effectively operating on the first detection channel A of this group of analog-to-digital converters 23. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 in electrode unit 12-6. Similarly, the voltage value collected on the second detection channel B of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 in electrode unit 12-7. The voltage value collected on the third detection channel C of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 in electrode unit 12-8. The voltage value acquired on the fourth detection channel D of the analog-to-digital converter 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-9. The voltage value acquired on the fifth detection channel E of the analog-to-digital converter 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-10.

[0087] When the third grounding switch 25-3 is closed, the first grounding switch 25-1, the second grounding switch 25-2, and the fourth grounding switch 25-4 are all open, and the first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, the third bidirectional switching switch 26-3, the fourth bidirectional switching switch 26-4, and the fifth bidirectional switching switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of the electrode units 12-11 to 12-15 in the third row group are energized, and the temperature sensors 14 of the electrode units 12-1 to 12-10 and the electrode units 12-16 to 12-20 in the other rows are de-energized. The signal terminals 14-2 of the temperature sensors 14 of the electrode units 12-1, 12-6, 12-11, and 12-16 in the first detection channel A of the analog-to-digital converter 23 are shorted. Since only the grounding terminal of the temperature sensor 14 of the electrode unit 12-11 is connected, the signal terminals 14-2 of the temperature sensors 14 of the electrode units 12-1, 12-6, 12-11, and 12-16 are connected.14-1 is grounded, while the grounding terminals 14-1 of the temperature sensors 14 of electrode units 12-1, 12-6, and 12-16 are all disconnected. Each electrode unit 12 has a diode 16 connected in series with the temperature sensor 14. The other temperature sensors 14 in the third row do not affect the resistance of the temperature sensor 14 in electrode unit 12-11. Therefore, only the temperature sensor 14 of electrode unit 12-11 is effectively operating on the first detection channel A of this group of analog-to-digital converters 23. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 in electrode unit 12-11. Similarly, the voltage value collected on the second detection channel B of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 in electrode unit 12-12. The voltage value collected on the third detection channel C of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 in electrode unit 12-13. The voltage value collected on the fourth detection channel D of the analog-to-digital converter 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-14. The voltage value collected on the fifth detection channel E of the analog-to-digital converter 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-15.

[0088] When the fourth grounding switch 25-4 is closed, the first grounding switch 25-1, the second grounding switch 25-2, and the third grounding switch 25-3 are all open, and the first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, the third bidirectional switching switch 26-3, the fourth bidirectional switching switch 26-4, and the fifth bidirectional switching switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of the electrode units 12-16 to 12-20 of the fourth row group are energized, and the temperature sensors 14 of the electrode units 12-1 to 12-15 of the other row groups are de-energized. The signal terminals 14- of the temperature sensors 14 of the electrode units 12-1, 12-6, 12-11, and 12-16 of the first detection channel A in this group of analog-to-digital converters are short-circuited. 2. Since only the grounding terminal 14-1 of the temperature sensor 14 in electrode unit 12-16 is connected to ground, while the grounding terminals 14-1 of the temperature sensors 14 in electrode units 12-1, 12-6, and 12-11 are disconnected, and each electrode unit 12 has a diode 16 connected in series with the temperature sensor 14, the remaining temperature sensors 14 in the fourth row will not affect the resistance value of the temperature sensor 14 in electrode unit 12-16. Therefore, only the temperature sensor 14 of electrode unit 12-16 is effectively operating on the first detection channel A of this group of analog-to-digital converters 23. At this time, the temperature detection signal (voltage) collected by the first detection channel A is...The voltage value is the voltage value of the temperature sensor 14 of electrode units 12-16. Similarly, the voltage value collected on the second detection channel B of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode units 12-17. The voltage value collected on the third detection channel C of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode units 12-18. The voltage value collected on the fourth detection channel D of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode units 12-19. The voltage value collected on the fifth detection channel E of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode units 12-20. Thus, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 can collect the temperature detection signals of the temperature sensors 14 of all electrode units 12 of the electrode unit 10 by controlling a set of bidirectional switching switches 26 and a set of grounding switches that are electrically connected to a certain electrode piece 10. Similarly, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of other electrode plates 10 can be obtained.

[0089] The first controller 22, multiple sets of analog-to-digital converters 23 and multiple sets of bidirectional switching switches 26 can be automatically executed by pre-programmed program code. For example, the first controller 22 first controls all bidirectional switching switches 26 in the corresponding set to switch to the sampling end 1 so that the sampling end 1 of these bidirectional switching switches 26 is all turned on and the input end 2 is all turned off so that each dual-purpose signal line 19 of the corresponding electrode plate 10 is electrically connected to the corresponding set of analog-to-digital converters 23. Then, the first grounding switch 25-1 in the corresponding set of grounding switches 25 is closed, and the remaining second grounding switches 25-2, third grounding switches 25-3 to fourth grounding switches 25-4 in the set of grounding switches 25 are turned off. During this period, each detection channel A, B, C of the set of analog-to-digital converters 23 is connected. D and E acquire the temperature detection signals of each temperature sensor 14 of each electrode unit 12 located in the first row group of the corresponding electrode sheet 10, convert them into digital signals, and store them in a separately set memory. Then, after a preset time interval, the first controller 22 closes the second grounding switch 25-2 in the group of grounding switches 25, and opens the first grounding switch 25-1, the third grounding switch 25-3, and the fourth grounding switch 25-4 in the group of grounding switches 25. During this period, the detection channels A, B, C, D, and E of the group of analog-to-digital converters 23 acquire the temperature detection signals of each temperature sensor 14 of each electrode unit 12 located in the second row group. By sequentially turning on each grounding switch 25 in the group of grounding switches 25, the temperature detection signals of all temperature sensors 14 located in each row group of the electrode sheet 10 can be obtained. Similarly, through this operation, the temperature detection signals of all temperature sensors 14 on at least one pair of electrode sheets 10 can be obtained.

[0090] The tumor electric field therapy system 100 of this application can achieve real-time and comprehensive temperature monitoring of all electrode units 12 on the electrode sheet 10 without increasing the weight of the electrode sheet 10 or the number of wire cores in the first cable 13 electrically connected to the electrode sheet 10. Based on the obtained temperature detection signals, it can determine whether the electrode sheet 10 is qualified; or it can determine whether the temperature sensor 14 of the electrode sheet 10 is faulty or abnormal, and determine whether the electrode sheet 10 needs to be replaced based on the number of faulty or abnormal temperature sensors 14; or, if the electrode sheet is qualified, it can identify the electrode sheet type based on the obtained temperature detection signals; or, if the electrode sheet is qualified, it can determine whether the electrode units 12 of the electrode sheet 10 are overheated based on the obtained temperature detection signals, and then control the alternating electrical signals applied to the electrode sheet 10 or the corresponding column of electrode units 12 of the electrode sheet 10, thereby avoiding low-temperature burns to the patient's skin during tumor treatment using the electrode sheet 10. Furthermore, the flexible circuit board 11 of the electrode sheet 10 of this application is electrically connected to the dielectric element 15 of the same electrode unit 12 and the signal terminal 14-2 of the temperature sensor 14 through the same dual-purpose signal line 19. This allows for the transmission of both AC signals and DC signals for temperature signal acquisition, as well as the acquired temperature detection signal, via the dual-purpose signal line 19. Simultaneously, it significantly reduces the number of conductive traces (grounding line 18, dual-purpose signal line 19) laid on it, reducing the wiring difficulty of the flexible circuit board 11, simplifying the manufacturing process, reducing the weight of the flexible circuit board 11, and lowering manufacturing costs. The electrode sheet 10 of this application can also switch between applying AC signals for tumor treatment and transmitting DC signals for temperature acquisition and transmitting the acquired temperature detection signal through a combination of a grounding switch 25 electrically connected to the grounding line 18 and a bidirectional switching switch 26 electrically connected to the dual-purpose signal line 19. (See page 20 / 34 of the specification, CN 120960639 A).

[0091] When the electrode pads 10 are properly connected and it is necessary to apply AC signals to the patient through each electrode unit 12 of a certain electrode pad 10, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls all the grounding switches 25 in a set of grounding switches 25 corresponding to the electrode pad 10 to be disconnected, and at the same time controls all the bidirectional switching switches 26 in a set of bidirectional switching switches 26 corresponding to the electrode pad 10 to be switched to their respective input terminals 2, so that the sampling terminals 1 of these bidirectional switching switches 26 are all disconnected and the input terminals 2 are all turned on, so that each dual-purpose signal line 19 of the electrode pad 10 is electrically connected to an AC signal line 28 corresponding to the adapter 20 and the electrode pad 10, thereby transmitting the AC signal to each electrode unit 12 of the electrode pad 10.Electrode unit 12. When the temperature detection signals of the temperature sensors 14 of all electrode units 12 of the detected electrode plate 10 are much lower than the preset temperature threshold stored in the electric field generator 30 or the adapter 20, the electric field generator 30 controls the AC signal generator 34 through its second controller 32 to continue generating an AC signal with an increased voltage or current amplitude or a constant voltage or current amplitude, and then transmits it to the corresponding electrode plate 10 through a corresponding AC signal line 28 of the adapter 20, so that the electrode plate 10 continues to be applied with an AC signal; when the temperature detection signals of the temperature sensors 14 of all electrode units 12 of the detected electrode plate 10 are lower than but close to the preset temperature threshold stored in the electric field generator 30 or the adapter 20, the electric field generator 30 can reduce the voltage or current of the AC signal generated by the AC signal generator 34 through the second controller 32, thereby reducing the voltage or current of the AC signal applied to the electrode plate 10; when an electrode unit 12 is detected on a certain electrode plate 1 ... When the temperature detection signal of the temperature sensor 14 exceeds a preset temperature threshold, the electric field generator 30 controls the AC signal switch 35 electrically connected to the electrode 10 to disconnect via the second controller 32, thereby stopping the application of AC signal to the electrode 10; or the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 controls all bidirectional switching switches 26 in a set of bidirectional switching switches 26 electrically connected to the electrode 10 to switch from their input terminal 2 to the sampling terminal 1, that is, controlling all bidirectional switching sampling terminals 1 of the set of bidirectional switching switches 26 electrically connected to the electrode 10 to be fully turned on. When all input terminals 2 are disconnected, the alternating electrical signal applied to the electrode 10 is stopped within a certain time limit; or, when the temperature detection signal of the temperature sensor 14 of the electrode unit 12 of a certain electrode 10 is detected to be greater than a preset temperature threshold, the second controller 32 of the electric field generator 30 controls the AC signal switch 35 electrically connected to the electrode 10 to continue conducting, and the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 controls a bidirectional switching switch 26 electrically connected to the electrode unit 12 of the electrode 10 to switch from its input terminal 2 to its sampling terminal 1, and the second controller 32 of the electric field generator 30... The first controller 22 of the controller 32 or adapter 20 simultaneously controls the input terminals 2 of the remaining bidirectional switches 26 that are electrically connected to the electrode units 12 in different columns from those whose temperature detection signals of the electrode pad 10 do not exceed a preset temperature threshold. This stops applying AC signals to all electrode units 12 in the same column as those whose temperature detection signals exceed the preset temperature threshold, and continues to apply AC signals to the remaining column electrode units 12 whose temperature detection signals do not exceed the preset temperature threshold. This enables the tumor electric field therapy system 100 to be based on temperature detection...A control method for applying AC signals in different regions. When applying AC signals, all grounding switches 25 are disconnected.

[0092] In this embodiment, the grounding switches 25 that are electrically connected to the multiple grounding lines 18 of the electrode plate 10 and the bidirectional switching switches 26 that are electrically connected to the multiple dual-purpose signal lines 19 of the electrode plate 10 are all provided in the adapter 20. However, in other embodiments, the grounding switches 25 that are electrically connected to the grounding lines 18 and the bidirectional switching switches 26 that are electrically connected to the dual-purpose signal lines 19 can also be provided on the electrode plate 10 or in the electric field generator 30, which will not be described in detail here. In addition, the analog-to-digital converter 23 provided in the adapter 20 can also be provided in the electric field generator 30 and directly controlled by the second controller 32. Specification 21 / 34 pages 24 CN 120960639 A

[0093] This application also provides other embodiments of the electrode plate 10. The differences between the multiple embodiments are mainly the different number of electrode units 12 and / or the different circuit distribution of the electrode units 12, which will be described separately below.

[0094] Figure 6 is a circuit connection diagram of the tumor electric field therapy system used in the second embodiment of this application, showing the circuit connection diagram between the electrode sheet 10D of the second embodiment and the adapter 20 of the first embodiment shown in Figure 1. The circuit is described below using the electrode sheet 10D of the second embodiment as an example. In terms of electrical connection, the electrode sheet 10D differs from the electrode sheet 10 of the first embodiment in the number of electrode units 12 and the circuit arrangement. The electrode sheet 10D in this embodiment has 13 of the aforementioned electrode units 12. In terms of electrical connection, the flexible circuit board 11D of the electrode sheet 10D arranges these 13 electrode units 12 in three rows and five columns in the circuit, where each of the two rows has 5 electrode units 12, and the remaining row has 3 electrode units 12. The flexible circuit board 11D of the electrode sheet 10D is embedded with 3 grounding lines 18, 5 dual-purpose signal lines 19, 1 grounding trace 171 that is connected to the grounding pin of the handshake chip 17 and any grounding line 28, and 1 communication line 172 that is connected to the communication pin of the handshake chip 17. Each grounding line 18 is used to ground the grounding terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in the corresponding row group. Each dual-purpose signal line 19 is short-circuited to the dielectric element 15 of each electrode unit 12 in each column group and the signal terminal 14-2 of each temperature sensor 14, for receiving temperature detection signals or transmitting AC signals. One grounding line 18 connected to the grounding trace 171 also grounds the grounding pin of the handshake chip 17.

[0095] The 3 grounding lines 18 of the flexible circuit board 11D are the first grounding line 18-1, the second grounding line 18-2 and the third grounding line 18-3. In the three rows of electrode sheet 10D, the first row includes electrode units 12-1 to 12-5, and the second row...The first row includes electrode units 12-6 to 12-10, and the second row includes electrode units 12-11 to 12-13. Specifically, the first grounding line 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-1 to 12-5 in the first row; the second grounding line 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-6 to 12-10 in the second row; the third grounding line 18-3 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-11 to 12-13 in the third row and is also used to ground the grounding pin of the handshake chip 17 through the grounding trace 171 connected to the grounding pin of the handshake chip 17. In short, each grounding line 18 short-circuits and grounds the grounding terminals 14-1 of the temperature sensors 14 of all electrode units 12 in the corresponding row group, and one of the grounding lines 18 also short-circuits and grounds the grounding pin of the handshake chip 17.

[0096] The five dual-purpose signal lines 19 of the electrode sheet 10D include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. The first dual-purpose signal line 19-1 One end of the first dual-purpose signal line 19-2 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode units 12-1, 12-6, and 12-11) and the signal terminal 14-2 of their respective temperature sensors 14; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode units 12-2, 12-7, and 12-12) and the signal terminal 14-2 of their respective temperature sensors 14; one end of the third dual-purpose signal line 19-3 is simultaneously connected to electrode units 12-3 and 12-8. Each of the three electrode units 12 (electrode units 12-13) has its own dielectric element 15 and its own temperature sensor 14 signal terminal 14-2; one end of the fourth dual-purpose signal line 19-4 is simultaneously connected to the dielectric element 15 and the temperature sensor 14 signal terminal 14-2 of each of the two electrode units 12 (electrode units 12-4 and 12-9); one end of the fifth dual-purpose signal line 19-5 is simultaneously connected to the dielectric element 15 and the temperature sensor 14 signal terminal 14-2 of each of the two electrode units 12 (electrode units 12-5 and 12-10). In short, each dual-purpose signal line 19 short-circuits the dielectric element 15 and the temperature sensor 14 signal terminal 14-2 of each electrode unit 12 located in a corresponding column group and connects them to the adapter 20.

[0097] The first grounding switch 25-1, the second grounding switch 25-2, and the third grounding switch 25-3 on the adapter 20 are connected through the firstA connector 40D is electrically connected to the first grounding wire 18-1, the second grounding wire 18-2, and the third grounding wire 18-3 of the electrode plate 10D respectively (see page 22 / 34 of the specification, CN 120960639 A). The fourth grounding switch 25-4 is in an idle and disconnected state. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, the fourth bidirectional switch 26-4, and the fifth bidirectional switch 26-5 on the adapter 20 are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, the fourth dual-purpose signal line 19-4, and the fifth dual-purpose signal line 19-5 of the electrode plate 10D respectively via the first connector 40D. A communication transmission line 211 on the adapter 20 is electrically connected to the communication line 172 connected to the communication pin of the handshake chip 17 of the electrode plate 10D.

[0098] The tumor electric field therapy system formed by the electrode 10D, the adapter 20 and the electric field generator 30 operates in the same way as the aforementioned tumor electric field therapy system 100. The second controller 32 of the electric field generator 30 sends a handshake communication signal to the first controller 22 of the adapter 20, and closes the third grounding switch 25-3 which is electrically connected to the handshake chip 17 of the electrode 10 through the first controller 22 of the adapter 20 or by directly controlling it. The handshake chip 17 is powered on. At this time, the first controller 22 sends a handshake communication signal to the handshake chip, and confirms that the electrode 10 is connected normally after receiving the feedback signal from the handshake chip 17. If no feedback signal is received from the handshake chip 17, it is confirmed that the electrode 10 is connected abnormally. When the electrode 10 is connected normally, the electric field transmitter 30 or the adapter 20 controls 1) all grounding switches 25 to be disconnected and the input terminals 2 and sampling terminals 1 of all bidirectional switching switches 26 to be turned on and disconnected, so that all dual-purpose signal lines 19 and AC signal lines 28 are connected. At this time, all electrode units 12 of the electrode 10 can apply AC signals; 2) the sampling terminals 1 and input terminals 2 of all bidirectional switching switches 26 are turned on and connected, and the grounding switches 25 are turned on in sequence, so that the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of each row group of the electrode 10 can be obtained in sequence. Among them, no operation is required for the grounding switches 25 that are in the idle disconnected state.

[0099] Referring to FIG7, it is a circuit connection diagram of the tumor electric field therapy system of the third embodiment of this application, showing a circuit connection diagram of the electrode 10E of the third embodiment and the adapter 20 shown in FIG1. The electrode sheet 10E, like the electrode sheet 10D in the second embodiment, has 13 electrode units 12, but the specific circuit layout is different. The flexible circuit board 11E of the electrode sheet 10E also arranges these 13 electrode units 12 in three rows and five columns, except that two of the rows are arranged differently.Each row has 4 electrode units 12, and the remaining row has 5 electrode units 12. The flexible circuit board 11E of the electrode sheet 10E also embeds 3 grounding lines 18, 5 dual-purpose signal lines 19, 1 grounding trace 171 that is simultaneously connected to the ground pin of the handshake chip 17 and any grounding line 28, and 1 communication line 172 that is connected to the communication pin of the handshake chip 17. Each grounding line 18 is used to ground the ground terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in the corresponding row group. Each dual-purpose signal line 19 shorts the dielectric element 15 of each electrode unit 12 in each column group and the signal terminal 14-2 of each temperature sensor 14, for receiving temperature detection signals or transmitting AC signals. One of the grounding lines 18 connected to the grounding trace 171 also grounds the ground pin of the handshake chip 17.

[0100] The three grounding wires 18 of the electrode sheet 10E include a first grounding wire 18-1, a second grounding wire 18-2, and a third grounding wire 18-3. The first row group includes electrode units 12-1 to 12-4, the second row group includes electrode units 12-5 to 12-8, and the third row group includes electrode units 12-9 to 12-13. Specifically, the first grounding wire 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-1 to electrode unit 12-4 in the first row group; the second grounding wire 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-5 to electrode unit 12-8 in the second row group; and the third grounding wire 18-3 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-9 to electrode unit 12-13 in the third row group, and grounds the grounding pin of the handshake chip 17 through the grounding trace 171 connected to the grounding pin of the handshake chip 17. In short, each grounding wire 18 short-circuits and grounds the grounding terminals 14-1 of the temperature sensors 14 of all electrode units 12 in each row group, and one grounding wire 18 also short-circuits and grounds the grounding pin of the handshake chip 17.

[0101] The five dual-purpose signal lines 19 of the electrode sheet 10E include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode unit 12-1, electrode unit 12-5, and electrode unit 12-9) and the signal terminal 14-2 of their respective temperature sensors 14; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode unit 12-2, electrode unit 12-6, and electrode unit 12-10) and the signal terminal 14-2 of their respective temperature sensors 14.Each temperature sensor 14 has a signal terminal 14-2; one end of the third dual-purpose signal line 19-3 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode units 12-3, 12-7, and 12-11) and the signal terminal 14-2 of their respective temperature sensors 14; one end of the fourth dual-purpose signal line 19-4 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode units 12-4, 12-8, and 12-12) and the signal terminal 14-2 of their respective temperature sensors 14; one end of the fifth dual-purpose signal line 19-5 is simultaneously connected to the dielectric element 15 of electrode unit 12-13 and the signal terminal 14-2 of temperature sensor 14. In short, each dual-purpose signal line 19 short-circuits the dielectric element 15 and the signal terminal 14-2 of each of the electrode units 12 located in the corresponding column group and connects them to the adapter 20.

[0102] The first grounding switch 25-1, the second grounding switch 25-2, and the third grounding switch 25-3 on the adapter 20 are electrically connected to the first grounding wire 18-1, the second grounding wire 18-2, and the third grounding wire 18-3 of the electrode plate 10E respectively via the first connector 40E. The fourth grounding switch 25-4 is in an idle and disconnected state. The first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, the third bidirectional switching switch 26-3, the fourth bidirectional switching switch 26-4, and the fifth bidirectional switching switch 26-5 on the adapter 20 are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, the fourth dual-purpose signal line 19-4, and the fifth dual-purpose signal line 19-5 of the electrode plate 10E respectively via the first connector 40E. A communication transmission line 211 on the adapter 20 is electrically connected to a communication line 172 connected to the communication pin of the handshake chip 17 of the electrode 10E.

[0103] The working mode of the tumor electric field therapy system formed by the electrode 10E, the adapter 20 and the electric field generator 30 is the same as that of the aforementioned tumor electric field therapy system 100. After the electric field generator 30 controls the adapter 20 to complete the handshake communication with the handshake chip 17 of the electrode 10E and confirms that the electrode 10E is connected normally, when all grounding switches 25 are open and the input terminal 2 of all bidirectional switching switches 26 is on and the sampling terminal 1 is off, all dual-purpose signal lines 19 and AC signal lines 28 are on, and all electrode units 12 can be applied with AC signals; when the sampling terminal 1 of all bidirectional switching switches 26 is on and the input terminal 2 is off, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 in each row group can be obtained sequentially by turning on each grounding switch 25 in sequence. Among them, no operation is required for the grounding switches 25 that are in the idle and disconnected state.

[0104] Referring to Figure 8, the electrode sheet 10F of the fourth embodiment, like the electrode sheet 10D of the third embodiment, has 13 electrode units 12, but the specific circuit layout is different. The flexible circuit board 11F of the electrode sheet 10F arranges these 13 electrode units 12 in four rows and four columns, with three rows each having four electrode units 12 and the remaining row having one electrode unit 12. The electrode sheet 10F includes four grounding lines 18, four dual-purpose signal lines 19, one grounding trace 171 connected to the grounding pin of the handshake chip 17 and any grounding line 28, and one communication line 172 connected to the communication pin of the handshake chip 17. Each grounding line 18 is used to ground the grounding terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in the corresponding row group. Each dual-purpose signal line 19 shorts the dielectric element 15 of each electrode unit 12 in each column group and the signal terminal 14-2 of each temperature sensor 14, for receiving temperature detection signals or transmitting AC signals. One grounding line 18 connected to the grounding trace 171 also grounds the grounding pin of the handshake chip 17.

[0105] The four grounding lines 18 of the electrode sheet 10F include a first grounding line 18-1, a second grounding line 18-2, a third grounding line 18-3, and a fourth grounding line 18-4. The first row group includes electrode units 12-1 to 12-4, the second row group includes electrode units 12-5 to 12-8, the third row group includes electrode units 12-9 to 12-12, and the fourth row group includes electrode units 12-13. Specifically, the first grounding wire 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-1 to electrode unit 12-4 in the first row group; the second grounding wire 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-5 to electrode unit 12-8 in the second row group; the third grounding wire 18-3 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-9 to electrode unit 12-12 in the third row group; and the fourth grounding wire 18-4 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-13 in the fourth row group. The fourth grounding wire 18-4 is also connected to the grounding trace 171 connected to the grounding pin of the handshake chip 17. In short, each grounding wire 18 short-circuits and grounds the grounding terminals 14-1 of the temperature sensors 14 of all electrode units 12 in each row group, and one of the grounding wires 18 also short-circuits and grounds the grounding pin of the handshake chip 17.

[0106] The four dual-purpose signal lines 19 of the electrode sheet 10F include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, and...The third dual-use signal line 19-3 and the fourth dual-use signal line 19-4. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric element 15 of each of the four electrode units 12 (electrode units 12-1, 12-5, 12-9, and 12-13) and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode units 12-2, 12-6, and 12-10) and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the third dual-purpose signal line 19-3 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode units 12-3, 12-7, and 12-11) and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the fourth dual-purpose signal line 19-4 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode units 12-4, 12-8, and 12-12) and the signal terminal 14-2 of each of their respective temperature sensors 14. In short, each dual-purpose signal line 19 shorts in parallel the signal terminals 14-2 of the dielectric elements 15 and temperature sensors 14 of each electrode unit 12 located in the same column group and connects them to the adapter 20.

[0107] The first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3 and the fourth grounding switch 25-4 on the adapter 20 are electrically connected to the first grounding wire 18-1, the second grounding wire 18-2, the third grounding wire 18-3 and the fourth grounding wire 18-4 of the electrode plate 10F respectively through the first connector 40F. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, and the fourth bidirectional switch 26-4 on the adapter 20 are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, and the fourth dual-purpose signal line 19-4 respectively via the first connector 40F. The fifth bidirectional switch 26-5 is in an idle and disconnected state. A communication transmission line 211 on the adapter 20 is electrically connected to the communication line 172, which is connected to the communication pin of the handshake chip 17 on the electrode plate 10F.

[0108] The tumor electric field therapy system formed by the electrode 10F, the adapter 20, and the electric field generator 30 operates in the same way as the aforementioned tumor electric field therapy system 100. After the handshake communication is completed with the first controller 22 of the adapter 20 through the handshake chip 17 and the connection of the electrode 10F is confirmed to be normal, when all grounding switches 25 are all open and the input terminals 2 of all bidirectional switching switches 26 are on, all dual-purpose signal lines 19 are connected to the AC signal line 28, and all electrode units 12 are connected to the AC signal; whenWhen the sampling terminal 1 of all bidirectional switching switches 26 is turned on, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 in each row group can be obtained sequentially by turning on each grounding switch 25 in sequence. Among them, no operation is required for the grounding switch 25 and / or the bidirectional switching switch 26 that are idle.

[0109] Referring to FIG9, it is a schematic diagram of the circuit connection between the electrode sheet and the adapter 20 in another embodiment of the tumor electric field therapy system of this application. In terms of electrical connection, the difference between the electrode sheet 10H in this embodiment and the aforementioned electrode sheet is that the number of electrode units 12 and the arrangement of the electrode units 12 in the circuit connection are also different. The electrode sheet 10H in this embodiment has 9 electrode units 12. The flexible circuit board 11H of the electrode sheet 10H arranges these 9 electrode units 12 in two rows and five columns in the circuit connection, with one row having 5 electrode units 12 and the other row having 4 electrode units 12. The flexible circuit board 11H of the electrode sheet 10H is embedded with two grounding lines 18, five dual-purpose signal lines 19, one grounding trace 171 connected to the grounding pin of the handshake chip 17 and any one of the grounding traces 28, and one communication line 172 connected to the communication pin of the handshake chip 17. Each grounding line 18 is used to ground the grounding terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in the corresponding row group. One grounding line 18 is also used to ground the grounding pin of the handshake chip 17. Each dual-purpose signal line 19 is short-circuited to the dielectric element 15 of each electrode unit 12 in each column group and the signal terminal 14-2 of each temperature sensor 14, for receiving temperature detection signals or transmitting AC signals.

[0110] The two grounding lines 18 of the electrode sheet 10H are the first grounding line 18-1 and the second grounding line 18-2. In the two rows of electrode sheet 10H, the first row includes electrode units 12-1 to 12-5, and the second row includes electrode units 12-6 to 12-9. Specifically, the first grounding wire 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-1 to 12-5 in the first row; the second grounding wire 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-6 to 12-9 in the second row, and simultaneously grounds the grounding pin of the handshake chip 17 through the grounding trace 171 connected to the grounding pin of the handshake chip 17. In short, each grounding wire 18 short-circuits and grounds the grounding terminals 14-1 of the temperature sensors 14 of all electrode units 12 in each row, and one grounding wire 18 also grounds the grounding pin of the handshake chip 17.

[0111] The five dual-purpose signal lines 19 of the electrode sheet 10H include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, andThe third dual-purpose signal line is 19-3, the fourth dual-purpose signal line is 19-4, and the fifth dual-purpose signal line is 19-5. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric element 15 of each of the two electrode units 12 (electrode unit 12-1 and electrode unit 12-6) and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric element 15 of each of the two electrode units 12-2 and electrode unit 12-7 and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the third dual-purpose signal line 19-3 is simultaneously connected to the dielectric element 15 of each of the two electrode units 12-3 and electrode unit 12-8 and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the fourth dual-purpose signal line 19-4 is simultaneously connected to the dielectric element 15 of each of the two electrode units 12-4 and electrode unit 12-9 and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the fifth dual-purpose signal line 19-5 is connected to the dielectric element 15 of the electrode unit 12-5 and the signal terminal 14-2 of the temperature sensor 14. In short, each dual-purpose signal line 19 shorts in parallel the signal terminals 14-2 of the dielectric elements 15 and temperature sensors 14 of each electrode unit 12 located in the corresponding column group and connects them to the adapter 20.

[0112] The first grounding switch 25-1 and the second grounding switch 25-2 on the adapter 20 are electrically connected to the first grounding wire 18-1 and the second grounding wire 18-2 of the electrode plate 10H respectively through the first connector 40H, and the third grounding switch 25-3 and the fourth grounding switch 25-4 are in an idle and disconnected state. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, the fourth bidirectional switch 26-4, and the fifth bidirectional switch 26-5 on the adapter 20 are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, the fourth dual-purpose signal line 19-4, and the fifth dual-purpose signal line 19-5 respectively via the first connector 40H. A communication transmission line 211 on the adapter 20 is electrically connected to the communication line 172, which is connected to the communication pin of the handshake chip 17 on the electrode plate 10H.

[0113] The tumor electric field therapy system formed by the electrode 10H, the adapter 20, and the electric field generator 30 operates in the same way as the aforementioned tumor electric field therapy system 100. After the electric field generator 30 controls the adapter 20 and the handshake chip 17 of the electrode 10E to complete the handshake communication and confirm that the electrode 10E is connected normally, when all grounding switches 25 are open and the input terminals 2 of all bidirectional switching switches 26 are on and the sampling terminals 1 are off, all dual-purpose signal lines 19 and AC signal lines 28 are on, and all electrode units 12 are connected.The AC signal is connected; when the sampling terminal 1 of all bidirectional switching switches 26 is turned on and the input terminal 2 is turned off, the temperature detection signal of the temperature sensor 14 of each electrode unit 12 in each row group can be obtained sequentially by turning on each grounding switch 25 in sequence. Among them, no operation is required for the grounding switch 25 in the idle and disconnected state. Specification 26 / 34 pages 29 CN 120960639 A

[0114] In the previous embodiment, the number of grounding switches 25 corresponding to each electrode piece 10, 10D, 10E, 10F, 10H of the adapter 20 is fixed at 4, and the number of bidirectional switching switches 26 corresponding to each electrode piece 10, 10D, 10E, 10F, 10H is fixed at 5. It can be used for various electrode pieces 10, 10D, 10E, 10F, 10H with different numbers of electrode units 12. However, in some cases, the grounding switch 25 and / or the bidirectional switching switch 26 in the idle and disconnected state will appear, which will be more complicated in terms of program control. To simplify the control program, specific adapters can be provided corresponding to the number of grounding wires 18 and dual-purpose signal lines 19 of the electrode plates, to avoid the occurrence of grounding switches 25 in an idle open state and / or bidirectional switching switches 26 in an idle open state, thus facilitating program control. That is, in other embodiments, the number of grounding switches 25 in each group of grounding switches 25 provided on the adapter 20 can be set according to the number of rows divided in the circuit connection of each electrode unit 12 of the corresponding electrode plate, or according to the number of grounding wires 18 on the flexible circuit board of the corresponding electrode plate; the number of bidirectional switching switches 26 in each group of bidirectional switching switches 26 provided on the adapter 20 can be set according to the number of columns divided in the circuit connection of each electrode unit 12 of the corresponding electrode plate, or according to the number of dual-purpose signal lines 19 on the flexible circuit board of the corresponding electrode plate. Preferably, the number of grounding switches 25 in each group of grounding switches 25 of the adapter 20 is equal to the number of rows of each electrode unit 12 of the corresponding electrode sheet in the circuit connection, or equal to the number of grounding wires 18 on the flexible circuit board of the corresponding electrode sheet; the number of bidirectional switching switches 26 in each group of bidirectional switching switches 26 provided on the adapter 20 is equal to the number of columns of each electrode unit 12 of the corresponding electrode sheet in the circuit connection, or equal to the number of dual-purpose signal lines 19 on the flexible circuit board of the corresponding electrode sheet.

[0115] The present invention also provides a method for detecting the temperature of electrode sheet 10 in a tumor electric field therapy system 100. Referring to FIG10, the method includes:

[0116] Step S10: performing handshake communication with the handshake chip 17 of the electrode sheet 10 through the adapter 20 to determine the connection status of the corresponding electrode sheet 10.

[0117] Step S20: when the electrode sheet 10 and the adapter 20 are connected normally, the adapter 20 is used to perform handshake communication with the electrode sheet 10 corresponding to the electrode sheet 10.The switching states of each grounding switch 25 and each bidirectional switching switch 26 are configured so that the temperature signals detected by each temperature sensor 14 in each row group are sampled sequentially through the corresponding temperature sampling points.

[0118] The present invention also provides an electrode type identification method. The electrode type identification is performed when all temperature sensors of the electrode are normally connected. In addition to the above steps S10 and S20, the method also includes:

[0119] Step S30: Identify the type of the corresponding electrode 10 according to the temperature signals detected by all temperature sensors 14 of the corresponding electrode 10.

[0120] The temperature signals detected by all temperature sensors 14 of the corresponding electrode 10 sampled in step S30 are temperature analog signals. Step S30 specifically includes the following steps:

[0121] Step S301: Perform digital-to-analog conversion on all sampled temperature analog signals to obtain several AD sampling values;

[0122] Step S302: Determine the number of electrode units 12 of the corresponding electrode sheet 10 according to the several AD sampling values;

[0123] Step S303: Determine the type of the corresponding electrode sheet 10 according to the number of electrode units 12.

[0124] The present invention also provides a method for judging abnormal temperature of an electrode sheet. The judgment of abnormal temperature of an electrode sheet is performed during the process of applying an alternating current signal to each electrode unit of the electrode sheet for tumor electric field therapy. In addition to the above steps S10 and S20, the method also includes the following steps:

[0125] Step S40: Judge whether the corresponding electrode sheet 10 has a temperature abnormality based on the temperature signals detected by all temperature sensors of the sampled corresponding electrode sheet.

[0126] Step S40 specifically includes the following steps:

[0127] Step S401: Compare all sampled temperature signals with a preset temperature threshold; Specification 27 / 34 pages 30 CN 120960639 A

[0128] Step S402: Determine whether there is a temperature abnormality in the electrode sheet based on the comparison results.

[0129] The comparison results in step S402 include temperature signals less than the preset temperature threshold and temperature signals greater than or equal to the preset temperature threshold. The determination of temperature abnormality is as follows: when there is a temperature signal greater than or equal to the preset temperature threshold among all sampled temperature signals, the electrode sheet temperature is determined to be abnormal; when all sampled temperature signals are less than the preset temperature threshold, the electrode sheet temperature is determined to be normal. The preset temperature threshold is 39℃-44℃, preferably 41℃.

[0130] The present invention also includes an alternating electrical signal adjustment method, which, in addition to steps S10 and S20, also includes: adjusting the alternating electrical signal applied to the corresponding electrode sheet according to the temperature signals detected by all temperature sensors of the corresponding electrode sheet. The regulation refers to adjusting the magnitude of the voltage, current, or power of the alternating electrical signal.

[0131] Referring to Figure 11, the present invention also provides an electric field control method applied to the tumor electric field therapy system 100, the electric field control method comprising the following steps:

[0132] In step 101, the tumor electric field therapy system 100 is connected.

[0133] Specifically, four electrode plates 10 are respectively connected to an adapter 20, the adapter 20 is connected to an electric field generator 30, and the electric field generator 30 is connected to a suitable power supply.

[0134] In step 102, it is detected whether the user issues a command to turn on the electric field. If no command to turn on the electric field is detected, step 102 is repeated; if a command to turn on the electric field is detected, step 103 is performed.

[0135] In step 103, after the electric field generator 30 of the tumor electric field therapy system 100 sends a handshake signal to the electrode 10 connected to the X1 port through the second connector 50, the adapter 20, and the first connector 40 connected to the X1 port, the first controller 22 of the adapter 20 receives the feedback signal from the electrode 10 at the X1 port through the corresponding communication transmission line 211 and determines whether the handshake is successful; if it fails, proceed to step 105; if it succeeds, proceed to step 106.

[0136] This determination step can occur in the adapter 20 or the electric field generator 30. In this embodiment, the determination step occurs in the adapter 20. Specifically, when the electrode 10 at the X1 port is connected normally, its handshake chip 17 can receive the handshake request signal from the electric field generator 30 and feed back the handshake status to the first controller 22 of the adapter 20. The first controller 22 determines that the handshake is successful. Conversely, if the electrode 10 at the X1 port is abnormally connected, the first controller 22 of the adapter 20 will not receive the feedback signal from its handshake chip 17, and the first controller 22 will determine that the handshake has failed.

[0137] In step 105, the tumor electric field therapy system 100 issues an alarm due to the handshake failure, and then proceeds to step 101.

[0138] In step 106, after the electric field generator 30 sends a handshake signal to the electrode 10 connected to the X2 port through the second connector 50, the adapter 20, and the first connector 40 connected to the X2 port, the first controller 22 on the adapter 20 receives the feedback signal from the electrode 10 at the X2 port through the corresponding communication transmission line 211, and determines whether the handshake has passed. If it has not passed, proceed to step 105; if it has passed, proceed to step 107.

[0139] This determination step can occur in the adapter 20 or the electric field generator 30. In this embodiment, the determination step occurs in the adapter 20. Specifically, when the electrode plate 10 at the X2 port is properly connected, its handshake chip 17 can receive the handshake request signal from the electric field generator 30 and report the handshake status to the first controller 22 of the adapter 20. The first controller 22 then determines that the handshake is successful. Conversely, when the electrode plate 10 at the X2 port is improperly connected, the first controller 22 of the adapter 20 cannot receive the handshake request signal from the electric field generator 30.If the feedback signal from the electrode 10 connected to the Y1 port is received, the first controller 22 determines that the handshake has failed.

[0140] In step 107, after the electric field generator 30 sends a handshake signal to the electrode 10 connected to the Y1 port through the second connector 50, the adapter 20, and the first connector 40 connected to the Y1 port, the first controller 22 on the adapter 20 receives the feedback signal from the electrode 10 connected to the Y1 port through the corresponding communication transmission line 211, and determines whether the handshake has passed. If it has failed, it proceeds to step 105; if it has passed, it proceeds to step 108.

[0141] This determination step can occur in the adapter 20 or the electric field generator 30. In this embodiment, the determination step occurs in the adapter 20. Specifically, when the electrode 10 at the Y1 port is connected normally, its handshake chip 17 can receive the handshake request signal from the electric field generator 30 and feed back the handshake status to the first controller 22 of the adapter 20. The first controller 22 determines that the handshake has succeeded. Conversely, if the electrode piece 10 at the Y1 port is abnormally connected, the first controller 22 of the adapter 20 will not receive the feedback signal from its handshake chip 17, and the first controller 22 will determine that the handshake has failed.

[0142] In step 108, after the electric field generator 30 sends a handshake signal to the electrode piece 10 connected to the Y2 port through the second connector 50, the adapter 20, and the first connector 40 connected to the Y2 port, the first controller 22 on the adapter 20 receives the feedback signal from the electrode piece 10 at the Y2 port through the corresponding communication transmission line 211, and determines whether the handshake has passed. If it has failed, proceed to step 105; if it has passed, proceed to step 109.

[0143] This determination step can occur in the adapter 20 or the electric field generator 30. In this embodiment, the determination step occurs in the adapter 20. Specifically, when the electrode 10 at port Y1 is connected normally, its handshake chip 17 can receive the handshake request signal from the electric field generator 30 and feed back the handshake status to the first controller 22 of the adapter 20. The first controller 22 determines that the handshake is successful. Conversely, when the electrode 10 at port Y2 is connected abnormally, the first controller 22 of the adapter 20 cannot receive the feedback signal from its handshake chip 17, and the first controller 22 determines that the handshake has failed.

[0144] In the above steps 103, 106, 107, and 108, after receiving the handshake signal from the tumor electric field therapy system 100, the adapter 20 needs to control the corresponding grounding switch 25 and bidirectional switching switch 26 through the first controller 22, so that the grounding switch 25 that is only electrically connected to the handshake chip 17 is closed, all other grounding switches 24 are opened, and the sampling terminal 1 of the corresponding bidirectional switching switch 26 is fully turned on and the input terminal 2 is fully turned off, so that the handshake chip 17 is connected to the grounding pin of the adapter 20 through the first connector 40.The GND electrical connection is used to ensure that the handshake chip 17 can function properly. If the electric field generator 30 is properly connected to the adapter 20, the adapter 20 to the adapter 20, and the adapter 20 to the electrode 10, the handshake signal emitted by the electric field generator 30 can eventually reach the handshake chip 17 of the electrode 10, and the handshake status of the handshake chip 17 can be fed back to the electric field generator 30. If at least one connection is abnormal between the electric field generator 30 and the adapter 20, the adapter 20 to the adapter 20, and the adapter 20 to the electrode 10, the handshake chip 17 cannot connect VCC and GND to form a circuit, resulting in the adapter 20 and the electric field generator 30 receiving an empty handshake status signal, and the handshake fails.

[0145] In step 109, the electric field generator 30 of the tumor electric field therapy system 100 sets the electric field parameters and then proceeds to step 110. The electric field parameters include the frequency of the alternating electric signal, the voltage or current or power amplitude, etc.

[0146] In step 110, the adapter 20 sends temperature reading requests to the first connector 40 at port Y1 and the first connector 40 at port Y2 to collect temperature detection signals corresponding to a total of 40 temperature sensors 14 on the electrode pads 10 at port Y1 and port Y2, and then proceeds to step 111.

[0147] In step 111, the tumor electric field therapy system 100 determines the type of the electrode pads 10 at port Y1 and port Y2 based on the collected temperature signals and then proceeds to step 112.

[0148] Specifically, the determination of the type of the electrode pads 10 at port Y1 and port Y2 is based on the number of temperature detection signals collected from the electrode pads 10 at port Y1 and port Y2 to determine the number of temperature sensors 14 for each electrode pad 10 at port Y1 and port Y2. This determination process can occur in the adapter 20 or the electric field generator 30. In this embodiment, the electrode 10 has 20 temperature sensors 14, thus having a total of 40 effective temperature signals.

[0149] In step 112, the tumor electric field therapy system 100 determines whether the temperature signal collected by the adapter 20 is abnormal. If it is abnormal, it proceeds to step 114. If all temperature signals are normal, it proceeds to step 113.

[0150] In step 113, the electric field generator 30 applies an alternating current signal to a pair of electrode 10 connected to ports Y1 and Y2, and simultaneously stops applying an alternating current signal to a pair of electrode 10 connected to ports X1 and X2, and proceeds to step 115. Specification 29 / 34 pages 32 CN 120960639 A

[0151] In step 114, the tumor electric field therapy system 100, due to the electrode 10 connected to port Y1 or connected to port Y2,An alarm is triggered if the temperature signal of the electrode 10 at the port is abnormal, and then the process immediately proceeds to step 120.

[0152] In step 115, the adapter 20 sends temperature reading requests to the first connector 40 of port X1 and the first connector 40 of port X2 to collect the temperature signals of all temperature sensors 14 on the electrode 10 at port X1 and port X2, and then proceeds to step 116.

[0153] In step 116, the tumor electric field therapy system 100 determines the type of the electrode 10 at port X1 and port X2 based on the temperature signals and then proceeds to step 117.

[0154] The type of the electrode 10 at port X1 and port X2 is determined by the number of temperature sensors 14 connected to the electrode 10 at port X1 and port X2. This determination process can occur in the adapter 20 or the electric field generator 30. In this embodiment, the electrode 10 has 20 temperature sensors 14, thus having a total of 40 effective temperature signals.

[0155] In step 117, the tumor electric field therapy system 100 determines whether the temperature signal collected by the adapter 20 is abnormal. If it is abnormal, it proceeds to step 114. If all 40 effective temperature signals are normal, it proceeds to step 118.

[0156] In step 118, the electric field generator 30 applies an alternating electrical signal to a pair of electrode 10 connected to ports X1 and X2, and simultaneously stops applying the alternating electrical signal to a pair of electrode 10 connected to ports Y1 and Y2, and proceeds to step 119. The total time for steps 113, 115, 116, 117 to 118 is fixed at 1 second.

[0157] In step 119, the tumor electric field therapy system 100 executes subsequent steps based on whether a user has issued a command to shut down the electric field. If a command to shut down the electric field is detected, the system proceeds to step 120; otherwise, it proceeds to step 121.

[0158] In step 120, after shutting down the electric field, the tumor electric field therapy system 100 proceeds to step 101. At this point, the electric field therapy ends, and the system awaits the next command to turn the electric field back on.

[0159] In step 121, the tumor electric field therapy system 100 determines whether the electric field parameters need to be adjusted based on the current electric field amplitude and the acquired temperature signal. If the electric field parameters need to be adjusted, the system proceeds to step 109; otherwise, it proceeds to steps 110 through 119 in a loop. The total time for steps 118, 119, 121, 110, 111, and 112 to 113 is fixed, which is 1 second in this embodiment. Thus, the tumor electric field therapy system 100 can apply an alternating electrical signal in a first direction between a pair of electrodes 10 connected to ports X1 and X2, and to another pair of electrodes connected to ports Y1 and Y2.Alternating electrical signals in the second direction are applied between the electrodes 10 and continuously output with a period of 2 seconds. Simultaneously, the tumor electric field therapy system 100 can reduce the time interval between turning off the alternating electrical signal applied to one pair of electrode plates 10 connected to ports X1 and X2 and turning on the alternating electrical signal applied to another pair of electrode plates 10 connected to ports Y1 and Y2 to 0 seconds; and reduce the time interval between turning off the alternating electrical signal applied to another pair of electrode plates 10 connected to ports Y1 and Y2 and turning on the alternating electrical signal applied to the pair of electrode plates 10 connected to ports X1 and X2 to 0 seconds, thereby extending the electric field therapy time while ensuring accurate temperature acquisition.

[0160] This application also provides some temperature detection methods and alternating electrical signal application control methods, which are described below using electrode plates 10 as an example.

[0161] This application embodiment provides an electrode temperature detection method, applied to the electrode 10 or tumor electric field therapy system 100 described above, as shown in FIG12, which includes the following steps:

[0162] Step 210: under the condition that the electrode is normally connected by a handshake chip, control each bidirectional switching switch 26 electrically connected to each electrode unit 12 of the electrode 10 to disconnect the AC signal applied to the dielectric element 15 of each electrode unit 12 of the electrode 10, and at the same time connect the DC signal applied to the signal terminal 14-2 of the temperature sensor 14 of each electrode unit 12 of the electrode 10;

[0163] Step 220: turn on the grounding switch 25 corresponding to the grounding terminal 14-1 of the temperature sensor 14 of each row group electrode unit 12 of the electrode 10 in a time-sequential manner to obtain the temperature detection signal of the temperature sensor 14 of each electrode unit 12 of the electrode 10.

[0164] Step 210 specifically involves: controlling the bidirectional switching switch 26 electrically connected to each electrode unit 12 of the electrode sheet 10 to switch from its end connected to the AC signal to its end connected to the DC signal, that is, controlling the bidirectional switching switch 26 electrically connected to the electrode sheet 10 to switch from its input terminal 2 to its sampling terminal 1; or

[0165] controlling the bidirectional switching switch 26 electrically connected to each electrode unit 12 of the electrode sheet 10 to switch the dielectric element 15 of each electrode unit 12 of the electrode sheet 10 from the on state to the off state, and at the same time switching the signal terminal 14-2 of the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10 from the off state to the on state.

[0166] The electrode sheet temperature detection method of this application can quickly and accurately obtain the temperature detection signals of all electrode units of the electrode sheet; and can determine whether the temperature sensor of the electrode sheet is faulty, abnormal, or whether the electrode sheet is qualified and needs to be replaced based on the obtained temperature detection signals of all temperature sensors of the electrode sheet; it can also be used in electrical...When the temperature sensors of the electrode are normal, the temperature detection signals of all the temperature sensors of the electrode are obtained to determine whether each electrode unit of the electrode is overheated and then control the AC signal applied to the electrode or the electrode unit of the electrode; the electrode type can also be identified when the temperature detection signals of the temperature sensors of the electrode are normal.

[0167] Referring to FIG13, the embodiment of this application also provides an AC signal application control method for tumor electric field therapy, which includes the above steps 210 and 220, and after step 220, it further includes:

[0168] Step 260: When it is determined that the electrode 10 does not need to be replaced, the AC signal applied to each electrode unit 12 of the electrode 10 is controlled or adjusted according to the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of the electrode 10.

[0169] Step 260 further includes controlling or adjusting the AC signal applied to each electrode unit 12 of the electrode sheet 10:

[0170] Step 261: When the temperature detection signals of each electrode unit 12 of the electrode sheet 10 are not exceeded by a preset temperature threshold, continue to apply AC signals to each electrode unit 12 of the electrode sheet 10; or

[0171] Step 262: When there is a temperature detection signal in all the temperature detection signals of the electrode units 12 of the electrode sheet 10 that exceeds the preset temperature threshold, stop applying AC signals to the electrode units 12 of the electrode sheet 10.

[0172] The step of stopping applying AC signals to the electrode units 12 of the electrode sheet 10 in step 262 includes stopping applying AC signals to all electrode units 12 of the electrode sheet 10, stopping applying AC signals to the electrode units 12 in the electrode sheet 10 whose temperature detection signals exceed the preset temperature threshold, and stopping applying AC signals to all electrode units 12 in the column where the temperature detection signals of the electrode units 12 in the electrode sheet 10 exceed the preset temperature threshold.

[0173] When the AC signal is stopped being applied to the electrode unit 12 in the electrode sheet 10 where the temperature detection signal exceeds the preset temperature threshold, the electrode unit 12 in the electrode sheet 10 where the temperature detection signal does not exceed the preset temperature threshold continues to be applied with an AC signal.

[0174] When the AC signal is stopped being applied to all electrode units 12 in the column where the temperature detection signal exceeds the preset temperature threshold is located, the electrode units 12 in the electrode sheet 10 where the temperature detection signal does not exceed the preset temperature threshold and are in a different column from the electrode unit 12 where the temperature detection signal exceeds the preset temperature threshold continues to be applied with an AC signal.

[0175] The process of continuing to apply an AC signal to the electrode sheet 10 in step 261 is specifically as follows: Specification page 31 / 34 34 CN 120960639 A

[0176] Step 263: When the temperature detection signal is much lower than the preset temperature threshold, the AC signal applied to each electrode unit 10 is increased.The AC signal is applied to each electrode unit 12 of the electrode sheet 10 in a manner that maintains the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10; or

[0177] Step 264: When the temperature detection signal approaches the preset temperature threshold, the AC signal is applied to each electrode unit 12 of the electrode sheet 10 in a manner that maintains the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10; or the AC signal is applied to each electrode unit 12 of the electrode sheet 10 in a manner that reduces the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10.

[0178] Referring to FIG14, this application also provides a signal control method for tumor electric field therapy, used for the above-mentioned electrode sheet 10. The method includes:

[0179] Step 310: Combining control of a set of grounding switches 25 and a set of bidirectional switching switches 26 electrically connected to the corresponding electrode sheet 10 to apply AC signals to each electrode unit 12 of the electrode sheet 10 and executing step 320;

[0180] Step 320: Combining control of a set of grounding switches 25 and a set of bidirectional switching switches 26 electrically connected to the electrode sheet 10 to collect temperature detection signals of each electrode unit of the electrode sheet 10 in a row and executing step 330;

[0181] Step 330: Determining the combination control mode of a set of grounding switches 25 and a set of bidirectional switching switches 26 electrically connected to the electrode sheet 10 according to the collected temperature detection signals and executing step 340;

[0182] Step 340: Controlling the working state of each electrode unit 12 of the electrode sheet 10 according to the determined combination control mode of grounding switches 25 and bidirectional switching switches 26.

[0183] The working state of each electrode unit 12 of the electrode sheet 10 in step 340 includes one of the following: stopping the application of AC signal and continuing to acquire temperature detection signal, and stopping the acquisition of temperature detection signal and continuing to apply AC signal. Continuing to apply AC signal includes continuing to apply AC signal by increasing the voltage or current amplitude of the currently applied AC signal, continuing to apply AC signal by keeping the voltage or current amplitude of the currently applied AC signal unchanged, and continuing to apply AC signal by decreasing the voltage or current amplitude of the currently applied AC signal.

[0184] The working state of each electrode unit 12 of the electrode sheet 10 is determined by the temperature detection signal it acquires. Each electrode unit 12 of the electrode sheet 10 is divided into different regions, and each electrode unit 12 in each region can be cyclically switched between applying AC signal and acquiring temperature detection signal by a combination of grounding switch 25 and bidirectional switching switch 26.

[0185] This application embodiment provides another electrode sheet temperature detection method for a tumor electric field therapy system, please refer toAs shown in Figure 15, taking electrode 10 as an example, the temperature detection method includes:

[0186] Step 510: Disconnect the AC signal input of electrode 10, perform combined control of multiple grounding switches 25 and multiple bidirectional switching switches 26, and acquire the temperature detection signal of the temperature sensor 14 of electrode 10 corresponding to each combination;

[0187] Step 520: Sample and convert the temperature detection signal detected by each temperature sensor 14 in electrode 10 to obtain a digital temperature signal;

[0188] Step 530: Transmit the digital temperature signal to the electric field generator 30 of the tumor electric field therapy system 100 so that the electric field generator 30 can determine the temperature at the corresponding electrode unit 12 according to the digital temperature signal.

[0189] In step 510, “combined control of multiple grounding switches 25 and multiple bidirectional switching switches 26” specifically includes:

[0190] Step 511: Place all bidirectional switching switches 26 at sampling end 1 to conduct the electrical connection between the signal terminals 14-2 of each temperature sensor 14 of all electrode units 12 and the corresponding analog-to-digital converter 23; Specification 32 / 34 pages 35 CN 120960639 A

[0191] Step 512: Sequentially close one of the multiple grounding switches 25 individually to collect the temperature detection signals detected by the temperature sensors 14 of each electrode unit 12 in the corresponding row group.

[0192] In step 512, sequentially closing one of the multiple grounding switches 25 individually can conduct the detection channel that is electrically connected to each temperature sensor 14 in the row group corresponding to the closed grounding switch 25.

[0193] Thus, the temperature detection signals of each temperature sensor 14 in each row group can be obtained sequentially, and then processed by the adapter 20 or the electric field generator 30 to obtain the temperature corresponding to all electrode units 12 on the electrode sheet 10; thereby making the temperature detection of the patient's body surface more comprehensive and accurate.

[0194] For the tumor electric field therapy system 100 of this application embodiment, temperature detection can also be performed on individual electrode units 12 as needed. The specific process of temperature detection for a certain electrode unit 12 of the electrode sheet 10 is as follows: disconnect the input of the AC signal, place the bidirectional switching switch 26 corresponding to the column group where the electrode unit 12 that needs to be measured individually is located at the sampling end 1, and place the remaining bidirectional switching switches 26 at the input end 2; at the same time, turn on and ground the grounding switch 25 corresponding to the row group where the electrode unit 12 that needs to be measured individually is located, and turn off all the remaining grounding switches 25. Thus, the temperature detection signal of the temperature sensor 14 in the electrode unit 12 that needs to be measured individually can be sampled to obtain the temperature of the electrode unit 12. For example, the electrode unit 12 that needs to be measured separately is electrode unit 12-1. In this case, the first electrode unit 12-1 is...The bidirectional switching switch 26-1 is placed at the sampling end 1, and the remaining bidirectional switching switches (second bidirectional switching switch 26-2, second bidirectional switching switch 26-3, third bidirectional switching switch 26-3 and fourth bidirectional switching switch 26-4) are all placed at the input end 2; at the same time, the first grounding switch 25-1 corresponding to the electrode unit 12-1 is closed and grounded, and the remaining grounding switches (second grounding switch 25-2, third grounding switch 25-3 and fourth grounding switch 25-4) are all opened. Thus, the temperature of the electrode unit 12-1 can be detected.

[0195] This application embodiment also provides another method for applying an alternating current signal for tumor electric field therapy, applied to the above-mentioned tumor electric field therapy system, and the tumor electric field therapy system 100 in FIG1 is used as an example for description. Referring to Figure 16, the AC signal application method includes:

[0196] Step 610: Determine the area where the electrode unit 12 in the electrode sheet 10 needs to be applied with an AC signal;

[0197] Step 611: Combine and control multiple grounding switches 25 and multiple bidirectional switching switches 26 that are electrically connected to the electrode sheet 10 to apply the AC signal.

[0198] Step 611, “combining control of multiple grounding switches 25 and multiple bidirectional switching switches 26 electrically connected to electrode plate 10”, specifically includes:

[0199] Step 612: Disconnecting all grounding switches 25 electrically connected to electrode plate 10;

[0200] Step 613: Determining the column group where the electrode unit 12 that needs to be applied AC signal is located, based on the area where the electrode unit 12 that needs to be applied AC signal is located;

[0201] Step 614: Determining the bidirectional switching switch 26 electrically connected to the electrode unit 12 in the column group based on the determined column group where the electrode unit 12 that needs to be applied AC signal is located;

[0202] In step 610: Dividing every four adjacent electrode units 12 in electrode plate 10 into a region, with four electrode units 12 in each region corresponding to a column group, connected to a dual-purpose signal line 19 corresponding to the same bidirectional switching switch 26. In other embodiments, the electrode units 12 may be divided in other ways, which will not be described here.

[0203] Step 615: Control the bidirectional switching switch 26 electrically connected to the electrode unit 12 that needs to be applied an AC signal to connect the electrode unit 12 that needs to be applied an AC signal to the AC signal line 28 to apply an AC signal; at the same time, control the remaining bidirectional switching switches 26 to disconnect the electrical connection between each electrode unit 12 in the area where no AC signal needs to be applied and the AC signal line 28, thereby stopping the application of AC signals. Specification 33 / 34 pages 36 CN 120960639 A

[0204] In step 615, "connect the electrode unit that needs to be applied an AC signal to the AC signal line 28 to apply an AC signal""Stopping the application of AC signal by disconnecting the electrical connection between the electrode unit 12 in the area where no AC signal needs to be applied and the AC signal line 28" is achieved by placing the bidirectional switching switch 26 electrically connected to the electrode unit 12 in the column group corresponding to the area in the electrode sheet 10 where the AC signal needs to be applied at its input terminal 2, and placing all the bidirectional switching switches 26 electrically connected to the electrode unit 12 in the remaining columns at the sampling terminal 1.

[0205] When the above methods are applied to the electrode sheets 10D, 10E, 10F and 10H in other embodiments, since there are grounding switches 25 and / or bidirectional switching switches 26 in the idle disconnected state that are not electrically connected to the corresponding electrode sheets 10D, 10E, 10F and 10H on the adapter 20, the corresponding grounding switches 25 and / or bidirectional switching switches 26 in the idle disconnected state do not need to be controlled.

[0206] Although the various operations are depicted in the accompanying drawings in a specific order, this should not be construed as requiring these operations to be performed in the specific order shown or in chronological order, nor should it be construed as requiring all the operations shown to be performed to obtain the desired result.

[0207] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and not to limit them; although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this application, and they should all be covered within the scope of the claims and specification of this application. In particular, as long as there is no structural conflict, the various technical features mentioned in the various embodiments can be combined in any way. This application is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims. Specification 34 / 34 pages 37 CN 120960639 A Figure 1 Specification Drawings 1 / 13 pages 38 CN 120960639 A Figure 2 Instruction manual, Figure 2 / 13, page 39, CN 120960639 A; Figure 3 / 13, page 40, CN 120960639 A; Figure 4 / 13, page 41, CN 120960639 A; Figure 5 / 13, page 42, CN 120960639 A; Figure 6 / 13, page 43, CN 120960639 A; Figure 7 / 13, page 44, CN 120960639 A; Figure 8. Instruction manual.Figure 8 / 13, page 45, CN 120960639 A, Figure 9, Figure 10, Specification Figure 9 / 13, page 46, CN 120960639 A, Figure 11, Specification Figure 10 / 13, page 47, CN 120960639 A, Figure 12, Figure 13, Specification Figure 11 / 13, page 48, CN 120960639 A, Figure 14, Figure 15, Specification Figure 12 / 13, page 49, CN 120960639 A, Figure 16, Specification Figure 13 / 13, page 50, CN 120960639 A {JSHL-26014-HKSPT / 02490372v1} Abstract The present invention provides an adapter and a tumor electric field therapy system. The tumor electric field treatment system comprises an electrode array, the electrode array is provided with a flexible circuit board, a plurality of electrode units and a handshake chip, and the electrode unit comprises a dielectric element and a temperature sensor having a signal end and a grounding end. The flexible circuit board is provided with multiple paths of grounding wires connected to the grounding ends and multiple paths of dual-purpose signal wires connected to the signal ends, and the dielectric element of the electrode unit is in short circuit with the signal end of the electrode unit. The adapter is provided witha plurality of grounding switches and a plurality of bidirectional switching switches, each grounding wire is grounded through a corresponding grounding switch, and each dual-purpose signal wire is electrically connected with a corresponding bidirectional switching switch. The bidirectional switching switch is provided with an input end for receiving an alternating current signal and a sampling end electrically connected to a corresponding detection channel of an analog-to-digital converter. After establishing handshake communications with the electrode array, the adapter is configured the states of each grounding switch and each bidirectional switching switch to apply the alternating current electric signal to the electrode array or to conduct temperature collections.

Claims

1. An adapter, characterized in that, It is electrically connected to the electrode pads of a tumor electric field therapy system. The electrode pads are provided with a flexible circuit board, a plurality of electrode units disposed on the flexible circuit board, and a handshake chip. The electrode unit includes a dielectric element and a temperature sensor with a signal terminal and a ground terminal. The flexible circuit board is provided with multiple grounding lines connected to each of the ground terminals and multiple dual-purpose signal lines connected to each of the signal terminals. The dielectric element of the electrode unit is short-circuited to the signal terminal. The handshake chip is configured to determine whether the electrode pad is properly connected through handshake communication. The plurality of electrode units are arranged in multiple rows and columns in the circuit. The ground terminals of each temperature sensor in the same row group are all connected to the same grounding line, and the ground terminals of each temperature sensor in different row groups are connected in parallel through different grounding lines. The signal terminals of each temperature sensor in the same column group are all connected to the same dual-purpose signal line, and the signal terminals of each temperature sensor in different column groups are connected in parallel through different grounding lines. The signal terminals are connected in parallel via different dual-purpose signal lines. The adapter is equipped with multiple grounding switches and multiple bidirectional switching switches corresponding to the electrode plates. Each grounding switch grounds each grounding wire of the electrode plate, and each bidirectional switch is electrically connected to each dual-purpose signal line of the electrode plate. The bidirectional switching switch has an input terminal for receiving AC signals and a sampling terminal electrically connected to a corresponding detection channel of the analog-to-digital converter. It is configured to transmit AC signals to the dielectric element of the corresponding electrode unit via the dual-purpose signal line electrically connected to it in a first mode when its input terminal is turned on; and to transmit DC signals to the signal terminal of the temperature sensor of the corresponding electrode unit via the dual-purpose signal line electrically connected to it in a second mode when its sampling terminal is turned on. When each grounding switch is turned on individually in sequence, it transmits the temperature signal detected by the temperature sensor via the dual-purpose signal line electrically connected to it.

2. The adapter according to claim 1, characterized in that, The adapter is configured to send a handshake signal to the handshake chip and receive a feedback signal from the handshake chip to determine whether it is properly connected to the electrode plate. When it is properly connected to the electrode plate, the adapter configures the states of each grounding switch and each bidirectional switching switch to enable the electrode plate to enter a first mode or a second mode.

3. The adapter according to claim 1 or 2, characterized in that, The adapter is equipped with a first controller, which controls the power-on of the handshake chip, the on and off of each of the grounding switches, and the on / off of each of the switching switches at its input or sampling terminal.

4. The adapter according to claim 1 or 2, characterized in that, The adapter is also provided with an AC signal line and a set of analog-to-digital converters with multiple detection channels corresponding to the electrode plate. The analog-to-digital converters receive the temperature signals detected by each of the temperature sensors in the second mode and convert them into multiple digital signals. The first controller determines the type of the electrode plate based on the multiple digital signals.

5. The adapter according to claim 4, characterized in that, The first controller determines whether the electrode plate has an abnormal temperature based on multiple digital signals.

6. The adapter according to claim 1, characterized in that, The flexible circuit board is also provided with a communication line that is electrically connected to the corresponding part of the handshake chip, and the adapter has a communication transmission line corresponding to the communication line.

7. A tumor electric field therapy system, characterized in that, It includes: An electrode sheet is provided with a flexible circuit board, a plurality of electrode units disposed on the flexible circuit board, and a handshake chip. Each electrode unit includes a dielectric element and a temperature sensor with a signal terminal and a ground terminal. The flexible circuit board has multiple grounding lines connected to each ground terminal and multiple dual-purpose signal lines connected to each signal terminal. The dielectric element of each electrode unit is short-circuited to the signal terminal. The plurality of electrode units are arranged in multiple rows and columns in the circuit. The ground terminals of each temperature sensor in the same row group are all connected to the same grounding line, while the ground terminals of each temperature sensor in different row groups are connected in parallel through different grounding lines. The signal terminals of each temperature sensor in the same column group are all connected to the same dual-purpose signal line, while the signal terminals of each temperature sensor in different column groups are connected in parallel through different dual-purpose signal lines. The handshake chip is configured to determine whether the electrode sheet is properly connected through handshake communication. as well as An adapter with a switching unit, wherein the switching unit is provided with multiple grounding switches and multiple bidirectional switching switches corresponding to the electrode plates, each grounding wire of the electrode plate is grounded through a corresponding grounding switch, and each dual-purpose signal line of the electrode plate is electrically connected to a corresponding bidirectional switching switch. The bidirectional switching switch has an input terminal connected to an AC signal and a sampling terminal electrically connected to a corresponding detection channel of an analog-to-digital converter, and is configured to transmit an AC signal to the dielectric element of the corresponding electrode unit through the dual-purpose signal line electrically connected thereto in a first mode when its input terminal is turned on; transmit a DC signal to the signal terminal of the temperature sensor of the corresponding electrode unit through the dual-purpose signal line electrically connected thereto in a second mode when its sampling terminal is turned on; and transmit the temperature signal detected by the temperature sensor through the dual-purpose signal line electrically connected thereto when each grounding switch is turned on individually in sequence.

8. The tumor electric field therapy system according to claim 7, characterized in that, The flexible circuit board is also provided with a ground trace and a communication line electrically connected to the handshake chip. The handshake chip has a ground pin electrically connected to the ground trace and a communication pin electrically connected to the communication line. The ground trace is electrically connected to one of the ground lines.

9. The tumor electric field therapy system according to claim 8, characterized in that, The adapter is provided with an AC signal line that is electrically connected to the input terminal of each of the bidirectional switching switches and transmits AC signals, as well as a communication transmission line corresponding to the communication line.

10. The tumor electric field therapy system according to claim 7, characterized in that, The adapter sends a handshake signal to the handshake chip and receives a feedback signal from the handshake chip. After determining that the electrode is normally connected to the adapter, the adapter configures the state of each grounding switch and each bidirectional switching switch to enable the electrode to enter either the first mode or the second mode.

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