Composition comprising hypochlorous acid for use in the treatment and prevention of onychomycosis

Abstract

The present invention relates to a hypochlorous acid-containing composition for treating and preventing onychomycosis, comprising: about 1 to 50,000 ppm of hypochlorous acid; a pH adjusting agent to adjust the pH of the composition to 2 to 9; and water. Preferably, the composition comprises 100 to 200 ppm of hypochlorous acid. Preferably, the composition includes a pH adjusting agent in an amount of 240 ppm or less. Preferably, the pH adjusting agent adjusts the pH of the composition to 5 to 6.5. Preferably, the pH regulator comprises one of sodium carbonate, sodium bicarbonate and calcium hydroxide. The hypochlorous acid can be used for inhibiting or killing trichophyton rubrum, candida albicans, fusarium, aspergillus, acremonium, acremonium, gliocladium brachypodum and other fungus strains and spores thereof with potential risk of causing gray beetles, so that fungi and spores in onychomycosis and other germs causing gray beetles are effectively treated, and repeated recurrence of gray beetles is avoided; a thorough solution is provided for patients, and a good method is provided for general public (including patients) to prevent formation of onychomycosis before symptoms of onychomycosis appear.

Description

(19) State Intellectual Property Office (12) Invention Patent Application (10) Application Publication Number (43) Application Publication Date (21) Application Number 202511812716.6 (22) Application Date 2025.12.04 (66) Domestic Priority Data 202411784481.X 2024.12.06 CN (71) Applicant Jacobson Trading Co., Ltd. Address Room A, 7 / F, Cheung Lung Industrial Building, 10 Cheung Yee Street, Cheung Sha Wan, Hong Kong, China (72) Inventor Lin Guoming (74) Patent Agency Beijing Bangzhong Intellectual Property Agency Co., Ltd. 11827 Patent Attorney Du Lijun Gu Yuanchun (51) Int.Cl. A61K 33 / 20 (2006.01) A61P 31 / 10 (2006.01) A61P 17 / 00 (2006.01) (54) Invention Title: Hypochlorous Acid-Containing Synthetic Compound for Treating and Preventing Onychomycosis (57) Abstract: This invention relates to a hypochlorous acid-containing synthetic compound for treating and preventing onychomycosis, comprising: about 1 to 50,000 ppm of hypochlorous acid; a pH adjuster to adjust the pH of the compound to 2 to 9; and water. Preferably, the compound comprises 100 to 200 ppm of hypochlorous acid. Preferably, the compound comprises a pH adjuster of less than 240 ppm. Preferably, the pH adjuster adjusts the pH of the compound to 5 to 6.5. Preferably, the pH adjuster comprises one of sodium carbonate, sodium bicarbonate, and calcium hydroxide. Hypochlorous acid can inhibit or kill Trichophyton rubrum, Candida albicans, Fusarium, Aspergillus, Cladosporium, Columnar Aureobasidium, and Cladosporium brevesii, as well as other fungal strains and spores that have the potential to cause onychomycosis. Therefore, it effectively treats the fungi and spores within the nails and other pathogens that cause onychomycosis, preventing recurrence and providing a complete solution for patients. It also provides the general public (including patients) with a good method to prevent the formation of onychomycosis before symptoms appear. Claims: 1 page; Description: 8 pages; Drawings: 3 pages; CN 122208628 A 2026.06.16 CN 1 22 20 86 28 A 1. A synthetic compound containing hypochlorous acid for treating and preventing onychomycosis, comprising: 1 to 50,000 ppm of hypochlorous acid; a pH adjuster to adjust the pH of the compound to between 2 and 9; and water. 2. The hypochlorous acid-containing compound of claim 1 for treating and preventing onychomycosis, wherein the compound comprises 100 to 200 ppm of hypochlorous acid. 3. The hypochlorous acid-containing compound of claim 2 for treating and preventing onychomycosis, wherein the compound comprises a pH adjuster below 240 ppm. 4. The hypochlorous acid-containing compound of claim 1 for treating and preventing onychomycosis, wherein the pH adjuster adjusts the pH of the compound to between 5 and 6.5.5. The synthetic compound containing hypochlorous acid for treating and preventing onychomycosis as described in claim 1, wherein the pH adjuster comprises one of sodium carbonate, sodium bicarbonate, and calcium hydroxide. 6. The synthetic compound containing hypochlorous acid for treating and preventing onychomycosis as described in claim 1, wherein the hypochlorous acid is prepared via electrolysis, synthesis, or ion exchange. 7. The synthetic compound containing hypochlorous acid for treating and preventing onychomycosis as described in claim 1, wherein the hypochlorous acid can inhibit or kill fungal strains and spores of fungi causing onychomycosis, including *Trichophyton rubrum*, *Candida albicans*, *Fusarium*, *Aspergillus*, *Cladosporium*, *Cyclophorus*, and *Cladophora brachytyla*, thus effectively treating fungi and spores within onychomycosis and other pathogens causing onychomycosis, preventing recurrence, providing a complete solution for patients, and offering the general public (including patients) a good method to prevent the formation of onychomycosis before symptoms appear. Claims 1 / 1 Page 2 CN 122208628 A Synthetic Compound Containing Hypochlorous Acid for Treating and Preventing Onychomycosis Technical Field

[0001] This invention relates to a synthetic compound for treating and preventing onychomycosis, and particularly to a synthetic compound containing hypochlorous acid for treating and preventing onychomycosis. Background Art

[0002] Onychomycosis (commonly known as nail fungus) is caused by infection with fungi (e.g., yeasts, molds, and dermatophytes). The most common site of occurrence is the nail, such as fingernails or toenails. When the fungus enters the nail bed, it feeds on keratin. If it is not treated in time, the nail will first show symptoms of white patches, then gradually turn yellow and thicken, eventually leading to breakage and shedding. For patients, in addition to being unsightly and affecting their personal image, it may also be contagious to others. In severe cases, it can also cause complications such as inflammation, pain, and bacterial infection, and even form cellulitis, which increases the difficulty of treatment.

[0003] However, current treatments for onychomycosis mainly include topical antifungal medications (e.g., ointments, solutions, oils), oral antifungal medications (e.g., terbinafine and itraconazole), and laser therapy. However, because the nail structure is quite strong, patients must file their nails before using topical antifungal medications; otherwise, the medication cannot penetrate the affected area to improve the infection. While oral antifungal medications can effectively inhibit fungi, they also produce many side effects (e.g., nausea, diarrhea, headache, etc.) and can affect liver and kidney function. As for laser surgery, it uses photothermal principles to kill fungi in the nail. Although it does not cause damage to the nail bed, nail groove, or nail itself, compared to the other two methods, laser treatment is not only expensive but also cannot completely cure onychomycosis, only temporarily improving its appearance, and it will recur after a period of time.

[0004] However, the recurrence and reinfection rate of onychomycosis is high, mainly because...Because fungi can divide into arthroconidia, which remain in the keratin layer and nail, arthroconidia are resistant to adverse environments and can survive in the nail for a long time. They can also evade the host's immune surveillance until the environment is favorable for growth. At this time, the arthroconidia will transform back into active and reproductive hyphae and invade the host epidermis. The formation of arthroconidia is known to be induced by a variety of factors, such as changes in the host tissue environment (e.g., subungual hyperkeratosis caused by hyphal growth), or the use of antifungal drugs can also stimulate the formation of arthroconidia. Therefore, when using antifungal drugs, the dosage needs to be increased to a sufficient concentration to eliminate fungal spores and prevent recurrence. However, high doses of drugs can be harmful to the host and may also cause the strain to develop drug resistance.

[0005] In addition, before onychomycosis is formally formed, the bacteria that cause onychomycosis already exist in the patient's nail bed in the form of bacteria and / or spores. Current antifungal methods are not effective against spores and have a higher chance of causing side effects, making them difficult to use daily for the prevention of onychomycosis.

[0006] Therefore, in summary, the present invention designs a synthetic compound containing hypochlorous acid for treating and preventing onychomycosis, which can effectively kill the fungi and spores that cause onychomycosis, thereby improving the symptoms of onychomycosis in patients and preventing recurrence of onychomycosis, as well as preventing the appearance of onychomycosis symptoms, in order to improve the shortcomings of the prior art and enhance industrial implementation and utilization, bringing a thorough solution to patients and providing a good method for the general public (including patients) to prevent onychomycosis. Summary of the Invention

[0007] The main objective of the present invention is to provide a synthetic compound containing hypochlorous acid for treating and preventing onychomycosis, which can avoid patients taking large amounts of oral medication and can kill the fungi and spores that cause onychomycosis (nail fungus) through its hypochlorous acid component under the premise of being safe for human contact, so that the patient's nails gradually return to normal growth, not only becoming stronger and the newly grown parts becoming light-colored and shiny, but also reducing pain and odor, and improving problems such as itching, cracking and redness of the skin around the nails. Meanwhile, the synthetic compound of the present invention can kill fungi and spore-form fungi, preventing fungi and / or fungi in spore form from lurking in the keratin layer and nails, causing symptoms of onychomycosis after a period of time, affecting the health, cleanliness, and appearance of patients and the general public (including patients).

[0008] Therefore, to achieve the above objectives, the present invention discloses a synthetic compound containing hypochlorous acid for treating and preventing onychomycosis, comprising: about 1 to 50,000 ppm of hypochlorous acid; a pH adjuster to adjust the pH value of the compound to between 2 and 9; and water.

[0009] Preferably, the synthetic compound comprises 100 to 200 ppm of hypochlorous acid.

[0010] Preferably, the pH adjuster adjusts the pH of the compound to between 5 and 6.5.

[0011] Preferably, the hypochlorous acid is produced by methods including electrolysis, synthesis, or ion exchange.

[0012] Preferably, the pH adjuster includes sodium carbonate, sodium bicarbonate, and calcium hydroxide, and other food-grade weakly alkaline additives with pH-adjusting capabilities.

[0013] Preferably, the compound includes a pH adjuster below 240 ppm.

[0014] Preferably, the hypochlorous acid can inhibit or kill Trichophyton rubrum, Candida albicans, Fusarium, Aspergillus, Cladosporium, Columnar Aureobasidium, and Cladosporium brevesii, and other fungal strains and spores that cause onychomycosis.

[0015] In summary, the present invention will be described in detail below with reference to specific embodiments. The following embodiments are for illustrative purposes only and are not intended to limit the scope of protection of the present invention. Those skilled in the art will readily understand that various non-critical parameters can be changed or adjusted to produce substantially the same results.

[0016] Figure 1 is an apparatus diagram and flowchart for preparing the hypochlorous acid-containing synthetic compound for treating onychomycosis according to the present invention by electrolysis.

[0017] Figure 2 is an apparatus diagram and flowchart for preparing the hypochlorous acid-containing synthetic compound for treating onychomycosis according to the present invention by synthesis.

[0018] Figures 3 and 4 are photographs of the affected area of ​​patient A before and after using the hypochlorous acid-containing synthetic compound for treating onychomycosis according to the present invention.

[0019] Figures 5 and 6 are photographs of the affected area of ​​patient B before and after using the hypochlorous acid-containing synthetic compound for treating onychomycosis according to the present invention. Detailed Description

[0020] First, the present invention provides a hypochlorous acid-containing synthetic compound for treating onychomycosis, comprising: 1 to 50,000 ppm of hypochlorous acid; a pH adjuster to adjust the pH value of the compound to between 2 and 9; and water. Instruction manual, page 2 / 8, CN 122208628 A

[0021] In a preferred embodiment, the concentration of hypochlorous acid is between 100 and 200 ppm. The pH adjuster can be sodium carbonate (Na2CO3), sodium bicarbonate (NaHCO3), or calcium hydroxide (Ca(OH)2) at a concentration of less than 240 ppm. Other pharmaceutical-grade or food-grade weakly alkaline additives can also be used. Those skilled in the art will understand that the concentration of the pH adjuster can be adjusted according to the concentration of hypochlorous acid to achieve the desired hypochlorous acid concentration and pH value.

[0022] The hypochlorous acid in the synthetic compound containing hypochlorous acid used to treat onychomycosis can be prepared by different methods, including electrolysis, synthesis, ion exchange, or other feasible methods. The preparation methods of electrolysis or synthesis are described below as examples. If different concentrations and pH values ​​are required, appropriate adjustments can be made to the parameters. The preparation method of electrolysis is as follows: <Electrolysis>Electrolysis of dilute hydrochloric acid produces hydrogen and chlorine gas. When chlorine gas is introduced into water, hydrochloric acid and hypochlorous acid are formed, as shown in the following reactions: 2HCl → H₂ + Cl₂ Cl₂ + H₂O → HCl + HClO Therefore, referring to Figure 1, in the preparation of hypochlorous acid, one side of the electrolytic cell is connected to a dilute hydrochloric acid feed cylinder via a dilute hydrochloric acid pump, and the other side is connected to a filtered water tank via a water pump. The controller controls the dilute hydrochloric acid pump and the water pump to ensure that the dilute hydrochloric acid and water flow into the electrolytic cell at a predetermined rate. Simultaneously, the controller controls the voltage of the electrolytic cell to obtain hypochlorous acid with a specific pH value and a specific effective chlorine concentration. At this point, the pH value of the hypochlorous acid is approximately below 3. Afterward, the hypochlorous acid is drained into a storage tank through a drain valve, and a pH adjuster is added, stirring until the ideal pH range of 5.0-6.5 is reached. Preferably, the effective chlorine concentration is 120-140 ppm.

[0023] <Synthesis Method>

[0024] Sodium hypochlorite reacts with dilute hydrochloric acid to release chlorine gas. When the chlorine gas is introduced into water, it forms salt and hypochlorous acid. The reaction formula is as follows: NaClO + HCl → HClO + NaCl. Please refer to Figure 2. In the preparation of hypochlorous acid, the mixer is connected to the hypochlorous acid cylinder, the hydrochloric acid cylinder, and the filtered water tank through the sodium hypochlorite pump, the hydrochloric acid pump, and the water pump, respectively. The controller controls the sodium hypochlorite pump, the hydrochloric acid pump, and the water pump to make sodium hypochlorite, hydrochloric acid, and water flow into the mixer at a predetermined rate to obtain hypochlorous acid. The rate of each material can be determined according to the desired pH value and ppm. The obtained hypochlorous acid flows into the storage tank through the drain valve without the need to add a pH adjuster. Preferably, the pH value is between 5.0 and 6.5, and the effective chlorine concentration is 135-145 ppm. The hypochlorous acid obtained by this method may have sodium chloride as a byproduct. Sodium chloride is neutral and does not affect the pH value.

[0025] It can be seen that the hypochlorous acid contained in the synthetic compound used to treat onychomycosis can be produced by electrolysis and synthesis. Each method has its advantages, as follows: <Electrolysis> 1. The hypochlorous acid water produced after electrolysis has a high ability to eliminate microorganisms.

[0026] 2. Only dilute hydrochloric acid is required as raw material, resulting in low operating costs.

[0027] 3. The machine is less affected by other parameters (such as changes in water quality and raw materials).

[0028] 4. The machine can be quickly adjusted to achieve the preset pH value and concentration.

[0029] 5. Low power consumption, energy saving and environmental protection.

[0030] <Synthesis>

[0031] 1. High effective chlorine concentration. When the pH value is maintained between 5 and 6.5, it is produced using dilute hydrochloric acid and sodium hypochlorite, and the effective chlorine concentration is 30-500 ppm.

[0032] 2. The hypochlorous acid water produced after synthesis has high pH stability. (Instruction manual, page 3 / 8, CN 122208628 A)

[0033] 3. No additives are needed to adjust the pH value.

[0034] 4. Low operating cost and few consumables.

[0035] 5. The machine has a high degree of automation and is easy to adjust.

[0036] Under normal circumstances, the synthetic compound containing hypochlorous acid used to treat onychomycosis will interact with bacteria, viruses, and fungi (containing spores) and kill them by inhibiting protein activity or destroying protein structure through its strong oxidizing properties.

[0037] In addition, hypochlorous acid will quickly transform into other synthetic compounds when exposed to air or ultraviolet light. Therefore, it is necessary to block ultraviolet light when storing hypochlorous acid to extend its shelf life. In one embodiment, the present invention further includes a storage bottle made of plastic, through which the synthetic compound containing hypochlorous acid used to treat onychomycosis is stored. In one embodiment, the plastic contains titanium dioxide, which makes the storage bottle less transparent to light and can block the influence of ultraviolet light on the stability of the hypochlorous acid concentration. No additional stabilizers are needed, which can avoid harm to animals, plants and the environment. Furthermore, if stored in a cool environment at room temperature, it can prevent the effective chlorine concentration in hypochlorous acid from decreasing, so that the compound can be stored for at least one year while maintaining more than 85% of its original concentration.

[0038] In addition, in order to test the bactericidal and fungal-killing effects of the hypochlorous acid-containing synthetic compound used to treat onychomycosis, the applicant conducted tests on various bacterial species according to EN1040, EN1650, EN13704:2002 and other test standards. The test results are shown in Table 1 below: Table 1 Bactericidal effect of the synthetic compound of the present invention on different bacterial species Specification 4 / 8 pages 6 CN 122208628 A

[0039] The above test standards are described below: Test standard EN1040: Add 8 parts of test product to 1 part of test microorganism and 1 part of water. Allow the mixture to interact within the contact time. Add 1 part of the mixture to 8 parts of neutralizer and 1 part of water for 5 minutes to stop the bactericidal activity. Obtain the final mixture and incubate for 2 days to allow the surviving bacteria (if any) to multiply. Count the bacterial colonies and compare them with the original culture. The test conditions include: test temperature 20℃±1℃; maximum contact time: 5min±10sec; sterilization instructions, page 5 / 8, CN 122208628 A, effect requirement (log): ≥5.

[0040] Test standard EN1650: Add 8 parts of test product to 1 part of test microorganism and 1 part of interfering substance. Allow the mixture to interact within the contact time. Add 1 part of the mixture to 8 parts of neutralizer and 1 part of water for 5 minutes to terminate the fungicidal or yeasticidal activity. Then obtain the final mixture and incubate for 3 days to allow the surviving microorganisms (if any) to multiply. Count the colonies and compare them with the original culture. The test conditions include: test temperature 20℃±1℃; maximum contact time: 5min±10sec; sterilization instructions, page 5 / 8, CN 122208628 A, effect requirement (log): ≥5.Interference time: 15 min; Interfering substance (clean conditions); 0.3 g / L bovine serum albumin solution; Interfering substance (non-clean conditions); 3 g / L bovine serum albumin solution; Sterilization effect requirement (log): ≥4.

[0041] Test standard EN13704:2002: Add 8 parts of test product to 1 part of test microorganism and 1 part of interfering substance. Allow the mixture to interact within the contact time. Add 1 part of the mixture to 8 parts of neutralizer and 1 part of water for 5 minutes to terminate antimicrobial activity. Then obtain the final mixture and incubate for 3 days to allow surviving spores (if any) to multiply. Count the colonies and compare them with the original culture size. The test conditions included: test temperature 4℃-75℃; contact time: 1min-60min; interfering substances (clean conditions); 0.3g / L bovine serum albumin solution; interfering substances (non-clean conditions); 3g / L bovine serum albumin solution; additional interfering substances from dairy products: 10g / L reconstituted milk; sterilization effect requirement (log): ≥3.

[0042] The test results show that the synthetic compound containing hypochlorous acid used to treat onychomycosis can achieve a sterilization rate of at least 99.9% against Escherichia coli, Staphylococcus aureus, Salmonella, Listeria, Candida albicans, Bacillus cereus, and Trichophyton mentagrophytes. The bacterial species in the table can represent different genera, among which Staphylococcus aureus can represent pyogenic cocci in vegetative bacteria; Escherichia coli can represent intestinal bacteria in vegetative bacteria; Candida albicans can represent pathogenic fungi; Bacillus cereus can represent bacterial spores; Trichophyton mentagrophytes can represent Trichophyton, etc., which are not all listed here.

[0043] Onychomycosis fungi include Candida albicans, Fusarium, Aspergillus, Acremonium, Scytalidium, Scopuliopsis brevicaulis, etc., whose strains and spores all belong to fungi. Therefore, according to the sensitivity ranking of microorganisms to disinfection agents in the "Disinfection Technical Specifications" (2022, 1.4.4.3), when the synthetic compound of the present invention can kill bacterial spores (Bacillus cereus), Candida albicans, and Trichophyton mentagrophytes, it is sufficient to prove that this synthetic compound has a certain degree of killing ability against fungal strains in the fungal kingdom and has a certain effect on inhibiting or killing all the above-mentioned onychomycosis fungi and their spores, thus effectively reducing the chance of onychomycosis recurrence.

[0044] In particular, among the pathogens of onychomycosis, Trichophyton rubrum accounts for 91.0% and Trichophyton mentagrophytes accounts for 7.7% (Uwe Wollina, Holger Haenssle, Dtsch Arztebl Int 2016;113(29-30):509-518), which are the two main pathogens.The present invention relates to a synthetic compound containing hypochlorous acid for treating onychomycosis, which can inhibit or kill major pathogens including Trichophyton rubrum or Trichophyton mentagrophytes.

[0045] Therefore, the present invention conducts experiments on the main pathogen Trichophyton rubrum and its spores to analyze the bactericidal effect of the synthetic compound of the present invention on the pathogen and spores. The experimental procedure is as follows: (1) Take 0.1 mL of bacterial solution and spread it on a 90 mm PDA (Potato Dextrose Agar) medium (bacterial count approximately 1 x 10⁶ CFU / mL), and place it for 5-15 minutes; (2) Spray the synthetic compound of the present invention onto the medium, wherein the spraying distance is 15 cm away from the medium, the spraying time is 2 seconds, and the contact time is maintained for 10 seconds, 15 seconds, 20 seconds, 30 seconds and 60 seconds respectively after spraying; (3) At each of the aforementioned time points, rinse the medium with 5 mL of neutralizing solution to stop the contact time, and perform sequential dilution, incubate at 25 degrees Celsius for 5 days, and count the bacterial count. Each group of experiments is repeated 3 times. The percentage of bactericidal effect is calculated based on the bacterial count of the control group. The results are shown in Tables 2 and 3 below: Table 2 Bactericidal effect of the synthetic compound of the present invention on Trichophyton rubrum cells 6 / 8 pages CN 122208628 A

[0046] Table 3 Bactericidal effect of the synthetic compound of the present invention on Trichophyton rubrum spores

[0047] As can be seen from the experimental results, the synthetic compound containing hypochlorous acid used to treat onychomycosis of the present invention can achieve a bactericidal effect of at least 99.9% on both the cell and spore forms of Trichophyton rubrum when the contact time is maintained for more than 20 seconds.

[0048] Furthermore, the present invention was also tested on actual patients, as described below: Patient A: A woman aged 46 to 55 years who had suffered from onychomycosis for more than 5 years, as shown in Figure 3A (2023 / 12 / 11). The symptoms of onychomycosis were obvious. After using the synthetic compound of the present invention as a wet compress 1-3 times a day for five consecutive months (2024 / 05 / 06), the affected area was significantly improved and new healthy nails began to grow, as shown in Figure 3B.

[0049] Patient B: A woman aged 23 years who had suffered from onychomycosis for more than 3 years, as shown in Figure 4A (2024 / 04 / 14). The symptoms of onychomycosis were obvious and severe. After using the synthetic compound of the present invention as a wet compress 2-3 times a day for six consecutive months (2024 / 10 / 12), the affected nails had recovered and healthy nails had regrowed, as shown in Figure 4B.

[0050] Furthermore, on June 18, 2024, six months after patient A used the synthetic compound containing hypochlorous acid for treating onychomycosis according to the present invention, the toenail of the original affected area was cut off. A portion of the toenail was mixed with 2 mL of sterilized water, and the resulting solution was aspirated and dropped into a culture dish for bacterial culture. The other portion of the toenail was directly cultured using a microbial incubator.Microscopic examination revealed the presence of spores. Experiments confirmed that no fungal spores or hyphae remained on the culture tray or under the microscope, demonstrating that the solution containing the synthesized chloric acid compound could eliminate fungi and spores in the affected nail, preventing recurrence of onychomycosis and providing a complete solution for patients.

[0051] Typical symptoms of onychomycosis include thickening, whitening, and brittleness of the nails or toenails. In particular, when onychomycosis develops over a long period, onycholysis may occur, where the nail gradually separates from the skin. When symptoms become severe, permanent damage and deformation of the nails can lead to impaired appearance and function, thereby affecting the quality of life. Through this invention, a synthetic compound containing hypochlorous acid is provided for treating onychomycosis. This avoids patients from taking large amounts of oral medication and, under the premise of being safe for human contact, kills the fungi and spores that cause onychomycosis through its hypochlorous acid component, allowing the patient's nails to grow normally, not only becoming strong and returning to a light and shiny color, but also reducing pain and odor, and improving problems such as itching, cracking, and redness of the skin around the nails. This proves that the solution mixed with the hypochlorous acid compound can eliminate the fungi and spores in the affected nail, prevent the recurrence of onychomycosis, and provide patients with a complete solution.

[0052] Now, referring again to Tables 1 and 2, Table 2 shows that the synthetic compound containing hypochlorous acid of this invention can effectively kill strains and spores of Trichophyton rubrum, while Table 1 shows that the compound can effectively kill strains of various fungi that cause onychomycosis. Based on the above results, it can be reasonably inferred that the synthetic compound of the present invention can effectively kill strains and spores of the aforementioned fungi and other structurally similar fungi.

[0053] Because the synthetic compound can kill the fungi that cause onychomycosis and their spores, it also indicates that the synthetic compound can not only treat onychomycosis, but also effectively prevent onychomycosis. The biggest difference between prevention and treatment is that prevention of onychomycosis means killing the fungi that cause onychomycosis and / or their spores before any onychomycosis symptoms have formed or are not yet visible, while at this time they may be latent or exist in the patient's nails in the form of fungi or their spores. Therefore, compared with the treatment of onychomycosis, the prevention of onychomycosis places more emphasis on the synthetic compound's ability to kill fungi in the spore state. Compared with existing drugs or other therapies for treating onychomycosis, the synthetic compound of the present invention has been proven to penetrate the nail layer of the nail to kill the spores of these fungi, thus killing the fungi and their spores before the symptoms of onychomycosis appear to prevent the formation of onychomycosis. In particular, fungal spores can survive in the nail bed for a long time. Once the spores enter the nail bed, routine cleaning and other treatments can no longer effectively penetrate the nail to kill the spores. Therefore, specific measures must be taken to prevent onychomycosis. Considering all factors, the synthetic compound of the present invention is the best choice.

[0054] As one example of use, if one needs to enter public places where there is a higher risk of onychomycosis infection, such as gyms, public transportation, or other places where fingers will inevitably touch other objects, or places with high humidity in the suburbs where sterilization may be insufficient, or other places with poor hygiene, the synthetic product of the present invention can be applied to the nail surface and the skin around the nail for a period of time after visiting these places to kill any fungi and their spores that may have been encountered.

[0055] As another example of use, for users with weak resistance, the synthetic product of the present invention can be used regularly to effectively prevent onychomycosis. The synthetic product of the present invention is non-irritating to the human body, has no medicinal properties, and will not produce drug resistance. It can be used daily or even several times without causing irritation, and can be stopped at any time. It can effectively prevent fungi and / or spores that may be contracted through daily contact from having sufficient time to grow and form onychomycosis.

[0056] Generally, the application methods of the synthetic compound can include, but are not limited to, spraying, wet compress, or soaking. Soaking ensures that the synthetic compound can contact every inch of the nail and surrounding skin, and softens the nail and skin tissue, making the synthetic compound penetrate more effectively and increasing the chance of reaching and killing fungi and / or spores. In contrast, wet compress and spraying methods require less synthetic compound and do not require additional aids, making them simpler to use while still providing sufficient bactericidal effect.

[0057] The above description is only a preferred embodiment of the present invention and should not be construed as limiting the scope of the present invention. That is, any simple equivalent changes and modifications made in accordance with the scope of the patent application and the description of the invention shall still fall within the scope of the patent of the present invention. Instruction Manual Page 8 / 8 10 CN 122208628 A Figure 1 Figure 2 Instruction Manual Drawings Page 1 / 3 11 CN 122208628 A Figure 3 Figure 4 Instruction Manual Drawings Page 2 / 3 12 CN 122208628 A Figure 5 Figure 6 Instruction Manual Drawings Page 3 / 3 13 CN 122208628 A ABSTRACT The present invention disclosed a composition comprising hypochlorous acid for use in the treatment and prevention of onychomycosis, comprising: 1 to 50,000 ppm hypochlorous acid; a pH buffer to adjust the pH of the composition to 2 to 9; and water. Preferably, the composition comprises 100to 200 ppm hypochlorous acid. Preferably, the composition comprises a pH buffer under 240 ppm. Preferably, the pH buffer adjusts the pH of the composition to 5 to 6.5. Preferably, the pH buffer comprises one of sodium carbonate, sodium bicarbonate and calcium hydroxide. The hypochlorous acid can suppress or eradicate both fungi and spores of Trichophyton rubrum, Candida albicans, Fusarium, Aspergillus, Acremonium, Scytalidium and Scopulariopsis brevicaulis and other potential onychomycosis-causing fungi. As a result, the present invention effectively treats both fungi and spores and other bacteria that causes fungal nail, preventing recurrence of fungal nail, providing a complete solution to patients, and also providing a good method of preventing onychomycosis from forming before its symptom appears for the general public (including patients).

Claims

1. Synthetic compounds containing hypochlorous acid used for the treatment and prevention of onychomycosis, including: Hypochlorous acid at concentrations of 1 to 50,000 ppm; pH adjuster to adjust the pH of the compound to between 2 and 9; as well as water.

2. The synthetic compound containing hypochlorous acid for treating and preventing onychomycosis as described in claim 1, wherein the synthetic compound comprises 100 to 200 ppm of hypochlorous acid.

3. The hypochlorous acid-containing compound for treating and preventing onychomycosis as described in claim 2, wherein the compound includes a pH adjuster at a concentration below 240 ppm.

4. The hypochlorous acid-containing compound for treating and preventing onychomycosis as described in claim 1, wherein the pH adjuster adjusts the pH of the compound to between 5 and 6.

5.

5. The hypochlorous acid-containing synthetic compound for treating and preventing onychomycosis as described in claim 1, wherein the pH adjuster comprises one of sodium carbonate, sodium bicarbonate, and calcium hydroxide.

6. The hypochlorous acid-containing compound for treating and preventing onychomycosis as described in claim 1, wherein the hypochlorous acid is produced by means of electrolysis, synthesis, or ion exchange.

7. The hypochlorous acid-containing compound for treating and preventing onychomycosis as described in claim 1, wherein the hypochlorous acid can inhibit or kill fungal strains and spores of fungi that cause onychomycosis, including Trichophyton rubrum, Candida albicans, Fusarium, Aspergillus, Cladosporium, Columnar Aureobasidium, and Cladosporium brevesii, thus effectively treating fungi and spores in onychomycosis and other pathogens that cause onychomycosis, preventing repeated recurrence of onychomycosis, providing a complete solution for patients, and providing the general public (including patients) with a good way to prevent the formation of onychomycosis before the symptoms appear.

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