Electric field generator and tumor electric field therapy system

Abstract

The invention provides an electric field generator and a tumor electric field treatment system, an electrode plate of the tumor electric field treatment system comprises a plurality of electrode units and a plurality of temperature detection units, the plurality of temperature detection units are divided into a plurality of row groups and a plurality of column groups, and the grounding ends of the temperature detection units in each row group are connected to the same grounding wire. The signal end of each temperature detection unit in each column group is in short circuit with the corresponding electrode unit and then is connected to the same dual-purpose signal line; a bidirectional change-over switch of the electric field generator is configured to switch a dual-purpose signal line to be connected to a temperature sampling point or an alternating power line, and when the dual-purpose signal line is connected to the temperature sampling point, each grounding line is conducted in sequence, so that a temperature detection signal detected by each temperature detection unit is sampled based on the temperature sampling point; and when the dual-purpose signal line is communicated with the alternating power line, an alternating current signal is transmitted to each electrode unit through the dual-purpose signal line, so that partition control and comprehensive temperature detection of the electrode plate are realized.

Description

(19) State Intellectual Property Office (12) Invention Patent Application (10) Application Publication Number (43) Application Publication Date (21) Application Number 202511686077.3 (22) Application Date 2024.10.25 (66) Domestic Priority Data 202311809226.1 2023.12.26 CN (62) Divisional Application Data 202411499593.0 2024.10.25 (71) Applicant Jiangsu Hailai Xinchuang Medical Technology Co., Ltd. Address 214100 No. 7, 7th Floor, Building 7, Huishan Avenue, Huishan Economic Development Zone, Wuxi City, Jiangsu Province Applicant Hangzhou Hailai Xinchuang Medical Technology Co., Ltd. (72) Inventors Ying Jianjun, Shen Qichao, Hui Jiajie, Yu Jing, Zhang Jun (51) Int.Cl. A61N 1 / 36 (2006.01) A61N 1 / 04(2006.01) G01K 13 / 00(2021.01) G01K 13 / 20(2021.01) G01N 25 / 00(2006.01) G01R 31 / 00(2006.01) H01R 13 / 70(2006.01) (54) Invention Title: Electric Field Generator and Tumor Electric Field Therapy System (57) Abstract: This application provides an electric field generator and a tumor electric field therapy system. The electrode pads of the tumor electric field therapy system include multiple electrode units and multiple temperature detection units. The multiple temperature detection units are divided into multiple row groups and multiple column groups. The grounding terminal of each temperature detection unit in each row group is connected to the same grounding line. The signal terminal of each temperature detection unit in each column group is short-circuited with the corresponding electrode unit and then connected to the same dual-purpose signal line. The bidirectional switching switch of the electric field generator is configured to switch the dual-purpose signal line to the temperature sampling point or the alternating power supply line. When the dual-purpose signal line is connected to the temperature sampling point, each grounding line is sequentially turned on so that the temperature detection signal detected by each temperature detection unit is sampled based on the temperature sampling point. When the dual-purpose signal line is connected to the alternating power supply line, an AC signal is transmitted to each electrode unit through the dual-purpose signal line to realize the zonal control and comprehensive temperature detection of the electrode pads. Claims 2 pages, Description 46 pages, Drawings 16 pages, CN 121371479 A 2026.01.23 CN 1 21 37 14 79 A 1. An electric field generator, characterized in that it is used to provide an alternating current signal to an electrode sheet of a tumor electric field therapy system, the electrode sheet comprising a plurality of electrode units and a plurality of temperature detection units, each electrode unit being capable of applying an alternating current signal, each temperature detection unit being respectively configured corresponding to one of the electrode units for detecting the temperature at each of the electrode units, the signal terminal of each temperature detection unit being short-circuited to the corresponding electrode unit, wherein the plurality of temperature detection units...The unit is configured in the circuit as multiple row groups and multiple column groups. The grounding terminals of each temperature detection unit in the same row group are shorted to the same grounding line. The grounding terminals of each temperature detection unit in different row groups are connected in parallel through different grounding lines. The signal terminals of each temperature detection unit in the same column group are shorted to the same dual-purpose signal line. The signal terminals of each temperature detection unit in different column groups are connected in parallel through different dual-purpose signal lines. The electric field generator is equipped with multiple control switches and multiple bidirectional switching switches corresponding to the electrode plates. Each grounding line of the electrode plate is connected through... The control switch is grounded, and each of the dual-purpose signal lines is electrically connected to the corresponding bidirectional switching switch; wherein the bidirectional switching switch is configured to switch each of the dual-purpose signal lines to a temperature sampling point or an alternating power supply line, so that (1) when each of the dual-purpose signal lines is connected to the temperature sampling point, each of the grounding lines is sequentially and individually turned on, so that the temperature detection signal detected by each of the temperature detection units is sampled based on the corresponding temperature sampling point; (2) when the dual-purpose signal line is connected to the alternating power supply line, the alternating electrical signal is transmitted to each of the electrode units through each of the dual-purpose signal lines. 2. The electric field generator according to claim 1, wherein each of the grounding lines of the electrode sheet is connected in series with the corresponding control switch and grounded through the corresponding control switch; each of the dual-purpose signal lines of the electrode sheet is connected in series with the corresponding bidirectional switching switch, and each of the bidirectional switching switches is provided with a signal acquisition terminal connected to a temperature sampling point and a signal input terminal connected to the alternating power supply line. 3. The electric field generator according to claim 2, characterized in that it is provided with an ADC unit, the ADC unit is provided with multiple detection channels, the signal acquisition terminal of each of the bidirectional switching switches is electrically connected to a corresponding detection channel through a corresponding temperature sampling point, and the ADC unit is configured to sample the temperature detection signals of each of the temperature detection units. 4. The electric field generator according to claim 1, characterized in that each of the dual-purpose signal lines is connected to different alternating power lines. 5. The electric field generator according to claim 1, characterized in that each of the dual-purpose signal lines is connected to the same alternating power line. 6. The electric field generator according to claim 1, characterized in that the electric field generator has a preset temperature threshold and is configured to: control the dual-purpose signal lines to transmit AC signals with increased or unchanged voltage or current amplitude to each of the electrode units when the temperature detection signals detected by each of the temperature detection units on the electrode sheet are much lower than the preset temperature threshold. 7. The electric field generator according to claim 6, characterized in that the electric field generator is configured to: when the temperature detection signals detected by each of the temperature detection units on the electrode sheet are much lower than the preset temperature threshold, control the dual-purpose signal lines to transmit AC signals with increased or unchanged voltage or current amplitude to each of the electrode units.When the temperature detection signal detected by the temperature detection unit on the electrode plate is lower than but close to the preset temperature threshold, the dual-purpose signal line is controlled to transmit the alternating electrical signal with reduced voltage or current amplitude to each of the electrode units. 8. The electric field generator according to claim 7, wherein the electric field generator is configured to: control the dual-purpose signal line to stop transmitting the AC signal to each of the electrode units when the temperature detection signal detected by the temperature detection unit on the electrode plate is greater than the preset temperature threshold. 9. The electric field generator according to claim 8, wherein the electric field generator is configured to: disconnect all the dual-purpose signal lines from the alternating power line when the temperature detection signal detected by the temperature detection unit on the electrode plate is greater than the preset temperature threshold, or disconnect only the dual-purpose signal line corresponding to the column group of the electrode unit with the temperature detection signal greater than the preset temperature threshold from the alternating power line while maintaining the connection of the remaining dual-purpose signal lines to the alternating power line. 10. The electric field generator according to claim 1, wherein each of the temperature detection signals is used to determine whether the electrode sheet is qualified, whether the temperature detection unit of the electrode sheet is faulty, whether the temperature detection unit of the electrode sheet is abnormal, or whether the electrode sheet needs to be replaced. 11. The electric field generator according to claim 10, wherein, if the electrode sheet is qualified, each of the temperature detection signals is used to identify the type of electrode sheet or to determine whether the electrode unit of the electrode sheet is overheated. 12. A tumor electric field therapy system, characterized in that it comprises: an electrode sheet including multiple electrode units and multiple temperature detection units, each electrode unit being capable of applying an alternating electrical signal, each temperature detection unit being configured corresponding to one of the electrode units for detecting the temperature at each of the electrode units, the signal terminals of each temperature detection unit being short-circuited to the corresponding electrode unit, wherein the multiple temperature detection units are configured in a circuit as multiple row groups and multiple column groups, the grounding terminals of each temperature detection unit located in the same row group are short-circuited to the same grounding line, the grounding terminals of each temperature detection unit located in different row groups are connected in parallel through different grounding lines, the signal terminals of each temperature detection unit located in the same column group are short-circuited to the same dual-purpose signal line, and the signal terminals of each temperature detection unit located in different column groups are connected in parallel through different dual-purpose signal lines; and an electric field generator, which is provided with multiple control switches and multiple bidirectional switching switches corresponding to the electrode sheet, each grounding line of the electrode sheet being grounded through a corresponding control switch, and each dual-purpose signal line being short-circuited to a corresponding electrode unit.A bidirectional switching switch is electrically connected; wherein the bidirectional switching switch is configured to switch each of the dual-purpose signal lines to a temperature sampling point or an alternating power supply line, so that (1) when each of the dual-purpose signal lines is connected to the temperature sampling point, each of the grounding lines is sequentially and individually turned on so that the temperature detection signal detected by each of the temperature detection units is sampled based on the corresponding temperature sampling point; (2) when the dual-purpose signal line is connected to the alternating power supply line, an alternating current signal is transmitted to each of the electrode units through the dual-purpose signal line. Claims 2 / 2 Page 3 CN 121371479 A Electric Field Generator and Tumor Electric Field Therapy System

[0001] This invention is a divisional application of the invention patent application filed by the applicant on October 25, 2024, with application number 202411499593.0 and invention title "Tumor Electric Field Therapy System, Electrode Sheet, Tumor Therapy Equipment and Method". Technical Field

[0002] This application relates to tumor electric field therapy technology, and more particularly to an electric field generator and a tumor electric field therapy system. Background Art

[0003] Tumor electric field therapy is a treatment method that uses low-intensity, medium-to-high-frequency alternating electric fields to prevent the formation of spindle microtubules during mitosis in certain tumor cells, inhibit the separation of intracellular organelles during cell division, and induce apoptosis during mitosis, thereby achieving the effect of treating tumors.

[0004] Compared with traditional cancer treatment methods, tumor electric field therapy has an innovative mechanism of action. Some physiological characteristics of tumor cells, such as their geometry and high-frequency mitosis, make them susceptible to the effects of tumor electric field therapy. Tumor electric field therapy disrupts the normal aggregation of tubulin by applying directional forces to polar particles (such as macromolecules and organelles) within the cell. These processes may lead to physical damage to the cell membrane and apoptosis. At the end of cell mitosis, the structural morphology of the cleavage groove leads to an uneven distribution of the electric field around it. Under the influence of tumor electric field therapy, the electric field intensity at the cleavage groove is significantly enhanced, and charged substances in the cell move towards the cleavage groove, interfering with or even destroying the formation of cell structures, which can ultimately lead to cell division failure and apoptosis.

[0005] In the related art, a tumor electric field therapy system uses an electric field application device to transmit an alternating electric signal for tumor electric field therapy to an electrode pad, and then applies an alternating electric field to the tumor site of the patient through the electrode pad for tumor electric field therapy. When the tumor treatment electric field is applied to the patient's body, heat will accumulate at the application site, and the temperature will rise accordingly. Therefore, it is necessary to monitor the temperature at the application site. When the temperature is too high, the electric field strength needs to be adjusted in time to reduce the risk of burns to the patient's skin due to excessive temperature.

[0006] The tumor electric field therapy system includes at least one pair of electrode pads, and each electrode pad contains multiple electrode units. Even if the same alternating electric signal is applied to each electrode unit, the heat generated on each electrode unit will vary due to its own characteristics.The temperature of each electrode unit on the entire electrode sheet will not be completely uniform due to its different location. This may result in some electrode units exceeding the preset temperature while others remain at a normal temperature. To improve the effect of tumor electric field therapy, it is necessary to individually control the overheated electrode units. However, for electrode sheets in related technologies, individual control of electrode units requires setting a conductive trace for each electrode unit in the substrate of the electrode sheet. This increases the number of conductive traces in the substrate, making the electrode sheet difficult to bend, and also thickens the cables electrically connected to the electrode sheet, increasing the overall weight of the electrode sheet and hindering its application. Summary of the Invention

[0007] This application aims to at least partially solve one of the technical problems in related technologies. To this end, the first objective of this application is to provide an electric field generator that can control multiple electrode units in sections using fewer conductive traces, which can not only improve the effect of tumor electric field therapy but also facilitate the application of the electrode sheet.

[0008] The second objective of this application is to provide a tumor electric field therapy system. Specification 1 / 46 pages 4 CN 121371479 A

[0009] To achieve the above objectives, the first aspect of this application provides: an electric field generator for adaptation to an electrode sheet of a tumor electric field therapy system, the electrode sheet comprising multiple electrode units and multiple temperature detection units, each electrode unit being capable of applying an alternating electrical signal, each temperature detection unit being configured corresponding to one of the electrode units for detecting the temperature at each of the electrode units, the signal terminals of each temperature detection unit being short-circuited to the corresponding electrode unit, wherein the multiple temperature detection units are configured in the circuit as multiple row groups and multiple column groups, the ground terminals of each temperature detection unit located in the same row group are short-circuited to the same grounding line, the ground terminals of each temperature detection unit located in different row groups are connected in parallel through different grounding lines, and the signal terminals of each temperature detection unit located in the same column group are short-circuited to the same grounding line. The signal terminals of the temperature detection units located in different columns are connected in parallel through different dual-purpose signal lines to the same dual-purpose signal line; the electric field generator is provided with multiple control switches and multiple bidirectional switching switches corresponding to the electrode plates, and each grounding wire of the electrode plate is grounded through a corresponding control switch, and each dual-purpose signal line is electrically connected to a corresponding bidirectional switching switch; wherein, the bidirectional switching switch is configured to switch each dual-purpose signal line to be connected to the temperature sampling point or the alternating power supply line, so that (1) when each dual-purpose signal line is connected to the temperature sampling point, each grounding wire is turned on sequentially and individually, so that the temperature detection signal detected by each temperature detection unit is sampled based on the corresponding temperature sampling point; (2) when the dual-purpose signal line is connected to the alternating power supply line, the grounding wire is turned on sequentially and individually, so that the temperature detection signal detected by each temperature detection unit is sampled based on the corresponding temperature sampling point;In the case of a source line, an AC signal is transmitted to each of the electrode units via each of the dual-purpose signal lines.

[0010] The electric field generator according to an embodiment of this application is provided with a control switch corresponding to the grounding wire of the electrode sheet and a bidirectional switching switch corresponding to the dual-purpose signal line of the electrode bias. The bidirectional switching switch can switch the dual-purpose signal line to be connected to a sampling point or an alternating power line. When the dual-purpose signal line is connected to a temperature sampling point, each grounding wire is sequentially turned on so that the temperature detection signal detected by each temperature detection unit is sampled based on the corresponding temperature sampling point. When the dual-purpose signal line is connected to an alternating power line, an alternating signal is applied to each electrode unit via each dual-purpose signal line. In this way, alternating signals can be applied to the electrode sheet in sections and comprehensive temperature detection can be achieved using fewer conductive traces.

[0011] To achieve the above objectives, a second aspect of this application provides: a tumor electric field therapy system, comprising: an electrode sheet including multiple electrode units and multiple temperature detection units, each electrode unit being capable of applying an alternating electrical signal, each temperature detection unit being configured corresponding to one of the electrode units for detecting the temperature at each electrode unit, and the signal terminals of each temperature detection unit being short-circuited to the corresponding electrode unit, wherein the multiple temperature detection units are configured in the circuit as multiple row groups and multiple column groups, the ground terminals of each temperature detection unit located in the same row group are short-circuited to the same grounding line, the ground terminals of each temperature detection unit located in different row groups are connected in parallel through different grounding lines, and the signal terminals of each temperature detection unit located in the same column group are short-circuited to the same dual-purpose signal line. The signal terminals of each temperature detection unit located in different columns are connected in parallel through different dual-purpose signal lines; and an electric field generator is provided with multiple control switches and multiple bidirectional switching switches corresponding to the electrode plates. Each grounding wire of the electrode plate is grounded through a corresponding control switch, and each dual-purpose signal line is electrically connected to a corresponding bidirectional switching switch. The bidirectional switching switch is configured to switch each dual-purpose signal line to be connected to a temperature sampling point or an alternating power supply line, so that (1) when each dual-purpose signal line is connected to the temperature sampling point, each grounding wire is sequentially and individually turned on, so that the temperature detection signal detected by each temperature detection unit is sampled based on the corresponding temperature sampling point; (2) when the dual-purpose signal line is connected to the alternating power supply line, an AC signal is transmitted to each electrode unit through each dual-purpose signal line.

[0012] The above description is merely an overview of the technical solution of this application. In order to better understand the technical means of this application and to implement it according to the contents of the specification, and to make the above and other objects, features and advantages of this application more apparent and understandable, specific embodiments of this application are described below. Specification 2 / 46 pages 5 CN 121371479 A Description of Drawings

[0013] Figure 1 is a schematic diagram of a tumor electric field therapy system according to an embodiment of this application;

[0014] Figure 2 is a schematic diagram of the structure of the electrode sheet of the tumor electric field therapy system shown in Figure 1;

[0015] Figure 3 is a schematic diagram of the circuit connection between an electrode sheet and an adapter of the tumor electric field therapy system shown in Figure 1;

[0016] Figure 4 is similar to Figure 3, but it is a schematic diagram of another circuit connection between an electrode sheet and an adapter shown in Figure 3;

[0017] Figure 5 is a schematic diagram of the circuit connection between an electrode sheet, an adapter, and an electric field generator of the tumor electric field therapy system shown in Figure 1;

[0018] Figure 6 is a schematic block diagram of the internal structure of the adapter of the tumor electric field therapy system shown in Figure 1;

[0019] Figure 7 is a schematic block diagram of the internal structure of the electric field generator of the tumor electric field therapy system shown in Figure 1;

[0020] Figure 8 is a flowchart of an electrode sheet temperature detection method according to an embodiment of this application;

[0021] Figure 9 is a flowchart of an electrode sheet abnormality detection method according to an embodiment of this application;

[0022] Figure 10 is a flowchart illustrating a control method for a tumor electric field therapy system according to an embodiment of this application;

[0023] Figure 11 is a flowchart illustrating an electrode type identification method according to an embodiment of this application;

[0024] Figure 12 is a flowchart illustrating a signal control method for tumor electric field therapy according to an embodiment of this application;

[0025] Figure 13 is a flowchart illustrating an electrode temperature detection method according to another embodiment of this application;

[0026] Figure 14 is a flowchart illustrating an alternating current signal application method for tumor electric field therapy according to another embodiment of this application;

[0027] Figure 15 is a flowchart illustrating an alternating current signal application method based on a temperature detection signal according to an embodiment of this application;

[0028] Figure 16 is a flowchart illustrating an alternating current signal application method based on a temperature detection signal according to another embodiment of this application.

[0029] FIG17 is a schematic diagram of a tumor electric field therapy system according to another embodiment of the present application;

[0030] FIG18 is a schematic diagram of the circuit connection between an electrode plate, an adapter, and an electric field generator in a tumor electric field therapy system according to another embodiment of the present application;

[0031] FIG19 is a schematic block diagram of the internal structure of the adapter of the tumor electric field therapy system shown in FIG18;

[0032] FIG20 is a schematic block diagram of the internal structure of the electric field generator of the tumor electric field therapy system shown in FIG18;

[0033] FIG21 is a flowchart of a control method for a tumor electric field therapy system according to another embodiment of the present application;

[0034] FIG22 is a flowchart of a signal control method for tumor electric field therapy according to another embodiment of the present application;

[0035] Explanation of reference numerals:

[0036] Tumor electric field therapy system 100 or 100', electrode plate 13 or 13', first cable 15 or 15', adapter 20 or20', second cable 25 or 25', electric field generator 30 or 30', substrate 31 or 31', electrode unit 33 or 33', temperature detection unit 35 or 35', grounding terminal 35-1 or 35-1', signal terminal 35-2 or 35-2', temperature sensor 34 or 34', grounding terminal 34- 1 or 34-1', signal terminal 34-2 or 34-2', electrode unit 33 or 33', diode 36 or 36', anode 36-1 or 36-1', cathode 36-2 or 36-2', second power module 32 or 32', second controller 37 or 37', second communication unit 38 or 38', AC signal generator 39 or 39', power switch 40 or 40', first controller 51 or 51', ADC unit 52 or 52', voltage divider resistor 53 or 53', control switch 54 or 54', first control switch 54-1 or 54-1', second control switch 54-2 or 54-2', third control... Control switch 54-3 or 54-3', fourth control switch 54-4 or 54-4', bidirectional switch 55 or 55', first bidirectional switch 55-1 or 55-1', second bidirectional switch 55-2 or 55-2', third bidirectional switch 55-3 or 55-3', fourth bidirectional switch 55-4 or 55-4', fifth bidirectional switch 55-5 or 55-5', first communication unit 56 or 56', alternating power line 57 or 57', first power module 58 or 58', grounding wire 18 or 18', first grounding wire 18-1 or 18-1', second grounding wire. (Instruction manual 3 / 46) Page 6 CN 121371479 A 18-2 or 18-2', third grounding wire 18-3 or 18-3', fourth grounding wire 18-4 or 18-4', dual-purpose signal line 19 or 19', first dual-purpose signal line 19-1 or 19-1', second dual-purpose signal line 19-2 or 19-2', third dual-purpose signal line 19-3 or 19-3', fourth dual-purpose signal line 19-4 or 19-4', fifth dual-purpose signal line 19-5 or 19-5', first connector 60 or 60', first plug 61, first socket 62, second connector 70 or 70', second plug 71 or 71', second socket 72 or 72'. Detailed Description

[0037] The embodiments of the technical solution of this application will be described in detail below with reference to the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solution of this application, and are therefore only examples, and cannot be used to limit the protection scope of this application.

[0038] Example 1:

[0039] FIG1 is a schematic diagram of a tumor electric field therapy system 100 according to an embodiment of the present application. As shown in FIG1, the tumor electric field therapy system 100 includes: at least one pair of electrode plates 13, an adapter 20 connected to the at least one pair of electrode plates 13, and a connector 20 connected to the adapter.The adapter 20 is connected to an electric field generator 30. At least one pair of electrode pads 13 can be disposed in pairs on the patient's body surface, as shown in Figure 1 with four electrode pads 13, each pair of electrode pads 13 disposed on the patient's body surface. The electric field generator 30 is used to supply power to the at least one pair of electrode pads 13, causing the at least one pair of electrode pads 13 to generate an alternating electric field for treating tumors. The adapter 20 is electrically connected between the at least one pair of electrode pads 13 and the electric field generator 30, for transmitting the alternating electrical signal generated by the electric field generator 30 to the at least one pair of electrode pads 13. That is, the electric field generator 30 is capable of generating an alternating electrical signal, which is transmitted to each electrode pad 13 through the adapter 20, so that an alternating electric field for treating tumors is generated between the same pair of electrode pads 13, thereby applying the alternating electric field to the tumor site of the patient for tumor treatment.

[0040] As shown in FIG1, in this embodiment, there are 4 electrode pads 13, each electrode pad 13 including the same number of electrode units 33, each electrode unit 33 being electrically connected to the adapter 20, and the number of electrode units 33 on each electrode pad 13 being 20. In some embodiments, the tumor electric field therapy system 100 may have more or fewer electrode pads 13; in some embodiments, each pair of electrode pads 13 has the same number of electrode units 33, and different pairs of electrode pads 13 may have different numbers of electrode units 33; in some embodiments, the number of electrode units 33 on each electrode pad 13 may be 9, 13, etc.

[0041] FIG3 and FIG4 are schematic diagrams of the circuit connection between the electrode pads 13 and the adapter 20 in two working states of the tumor electric field therapy system 100 shown in FIG1. It is worth noting that the arrangement of electrode units 33 shown in Figures 3 and 4 is for the purpose of more clearly illustrating the electrical connection between an electrode sheet 13 and the adapter 20. The arrangement of electrode units 33 shown in Figures 3 and 4 does not represent the spatial arrangement of electrode units 33. Referring to Figures 1, 3, and 4, the electrode sheet 13 includes: a substrate 31, a plurality of electrode units 33 electrically connected at intervals to the substrate 31, a plurality of temperature detection units 35, and a first cable 15 electrically connected to the substrate 31. The substrate 31 may be a flexible circuit board. Multiple conductive traces are embedded in the substrate 31, including multiple ground lines 18 and multiple dual-purpose signal lines 19. The first cable 15 has multi-core wires (not shown), each of which is electrically connected to the multiple ground lines 18 and the multiple dual-purpose signal lines 19 of the substrate 31, respectively. In this embodiment, the total number of grounding wires 18 and dual-purpose signal lines 19 embedded in the substrate 31 does not exceed 10, therefore the number of wires in the first cable 15 does not exceed 10.

[0042] Multiple electrode units 33 are configured into multiple row groups and multiple column groups. In this embodiment, on each electrode sheet 13There are 20 electrode units 33, which are grouped in the circuit connection according to the order 1 to 20, and divided into four row groups and five column groups, that is, the 20 electrode units 33 are arranged in four rows and five columns in the circuit connection. Each electrode unit 33 corresponds to a temperature detection unit 35, and each temperature detection unit 35 has a signal terminal 35-2 and a ground terminal 35-1. The electrode units 33 and the temperature detection units 35 are both soldered on the substrate 31, and the signal terminal 35-2 of the corresponding temperature detection unit 35 is shorted. Since multiple temperature detection units 35 are arranged in a one-to-one correspondence with multiple electrode units 33, the multiple temperature detection units 35 are also arranged in four rows and five columns in the circuit connection. It should be noted that the arrangement shown here is for clearer illustration of the electrical connection between the electrode pad 13 and the adapter 20, and does not represent the spatial arrangement of the electrode units 33. The spatial structure may be a roughly array-like structure as shown in Figure 2, or other structures such as petal-shaped or scattering-shaped structures; it can be regular or irregular. The electrode units 33 are configured to apply an alternating electric field to the patient's tumor site. The temperature detection unit 35 is configured to detect the temperature of the patient's body surface in contact with the electrode pad 13, i.e., the temperature at the corresponding electrode unit 33, and output a temperature detection signal to the adapter 20. In this embodiment, the multiplexed signal lines 19 of the substrate 31 are respectively arranged in a one-to-one correspondence with multiple columns of the electrode units 33, and are configured to transmit the alternating electrical signal generated by the electric field generator 30 to each electrode unit 33 in the corresponding column. That is, the electrode units 33 located in the same column are all short-circuited through the same dual-purpose signal line 19 of the substrate 31, and the electrode units 33 located in different columns are connected in parallel through different dual-purpose signal lines 19 of the substrate 31. The dual-purpose signal line 19 of the substrate 31 is electrically connected to the first cable 15, and then electrically connected to the electric field generator 30 through the adapter 20. Further, the dual-purpose signal line 19 of the substrate 31 receives the alternating electrical signal generated by the electric field generator 30 through the first cable 15 and the adapter 20.

[0043] The electrode pads 13 have three working modes. In the first mode, an alternating current signal is applied through the electrode unit 33; in the second mode, the temperature of the patient's body surface to which the corresponding electrode unit 33 is applied is detected or collected by the temperature detection unit 35; in the third mode, the application of the alternating current signal is stopped and the temperature detection and collection are stopped. The first mode, the second mode, and the third mode do not overlap in time period. That is, the time period during which the electrode unit 33 applies the alternating current signal and the time period during which the temperature detection unit 35 detects the temperature are staggered and do not overlap. Electrode 13 can apply an alternating current signal through its electrode unit 33 andThe temperature detection unit 35 cycles through the temperature detection, that is, the electrode 13 cycles through the first mode and the second mode. The electrode 13 can also cycle through the first mode, the second mode, and the third mode, that is, the electrode 13 cycles through the application of AC signal through the electrode unit 33, the temperature acquisition or detection through the temperature detection unit 35, the cessation of the application of AC signal, and the temperature acquisition.

[0044] The multiple grounding wires 18 are respectively set one-to-one with the multiple rows of the electrode unit 33, and the multiple grounding wires 18 are used to short-circuit and ground each temperature detection unit 35 in each row group in turn. That is, the grounding terminals 35-1 of the multiple temperature detection units 35 located in the same row group are all short-circuited through the same grounding wire 18 of the substrate 31, and the grounding terminals 35-1 of the temperature detection units 35 located in different rows are connected in parallel through different grounding wires 18 of the substrate 31. During the time period of temperature detection, only one of the multiple grounding wires 18 is conducting at any given time, and the other three are disconnected.

[0045] Each of the multiplexed dual-purpose signal lines 19 is further configured to short-connect the signal terminal 35-2 of at most one temperature detection unit 35 in each row group to an external device for receiving detection signals. The signal terminals 35-2 of the temperature detection units 35 connected to each of the multiplexed dual-purpose signal lines 19 are different to avoid subsequent repetitive signal outputs from the dual-purpose signal lines 19. That is, when the number of electrode units 33 in a row group is the same as the number of dual-purpose signal lines 19, each dual-purpose signal line 19 is electrically connected to the signal terminal 35-2 of a different temperature detection unit 35 in that row group; when the number of electrode units 33 in a row group is less than the number of dual-purpose signal lines 19, at least one dual-purpose signal line 19 is not electrically connected to the signal terminal 35-2 of a temperature detection unit 35, and the remaining dual-purpose signal lines 19 are electrically connected to the signal terminal 35-2 of a different temperature detection unit 35 in that row group. In this embodiment, the external device for receiving the detection signal is an adapter 20. The signal terminals 35-2 of the multiple temperature detection units 35 located in different columns are connected in parallel through different dual-purpose signal lines 19 of the substrate 31. The signal terminals 35-2 of the multiple temperature detection units 35 located in the same column are all shorted to the same dual-purpose signal line 19 of the substrate 31. Specification 5 / 46 pages 8 CN 121371479 A

[0046] In this embodiment, when each electrode unit 33 is equipped with a temperature detection unit 35 for temperature detection, the above-mentioned circuit design reduces the number of wires in the first cable 15, avoiding the cable from becoming thicker and harder, thus increasing the difficulty of cable fixation; at the same time, it avoids the increased number of wires in the first cable 15 affecting the corresponding body of the electrode plate 13 and the patient's tumor site.The adhesion effect between the surfaces. The substrate 31 has a total of 9 lines, including the grounding line 18 and the dual-purpose signal line 19. Specifically, in this embodiment, the substrate 31 has 4 grounding lines and 5 dual-purpose signal lines. The number of grounding lines 18 is related to the number of rows M of the electrode unit 33, which is greater than or equal to the number of rows of the electrode unit 33, and M is a positive integer. The number of dual-purpose signal lines 19 is related to the number of columns N of the electrode unit 33, which is greater than or equal to the number of columns of the electrode unit 33, and N is a positive integer. The number of lines L embedded in the substrate 31 of the electrode sheet 13 is equal to the sum of the number of grounding lines 18 and the number of dual-purpose signal lines 19. In this embodiment, the number of grounding lines 18 is equal to the number of rows M of the electrode unit 33; the number of dual-purpose signal lines 19 is equal to the number of columns N of the electrode unit 33.

[0047] Multiple electrode units 33 are arranged on the substrate 31 in a roughly two-dimensional array. As shown in Figure 2, the electrode sheet 13 in this embodiment includes 20 electrode units 33 and 20 temperature detection units 35 corresponding to the electrode units 33. The 20 electrode units 33 are arranged in a four-row, six-column array. The first and fourth rows each have four electrode units 33, and the second and third rows each have six electrode units 33. The four electrode units 33 in each of the first and fourth rows are located in each of the second to fifth columns, and the six electrode units 33 in each of the second and third rows are located in each of the first to sixth columns. The four electrode units 33 in the first row are divided into region 1; the electrode units 33 in the first column of the second row, the first column of the third row, and the second and third columns of the fourth row are divided into region 2; the electrode units 33 in the sixth column of the second row, the sixth column of the third row, and the fourth and fifth columns of the fourth row are divided into region 3; the electrode units 33 in the second and third columns of the second row and the second and third columns of the third row are divided into region 4; and the electrode units 33 in the fourth and fifth columns of the second row and the fourth and fifth columns of the third row are divided into region 5. Each region (1-5) corresponds to a column group. In some other embodiments, the 20 electrode units 33 may also be arranged in other ways. Of course, in some other embodiments, the electrode sheet 13 may also have other numbers of electrode units 33. In summary, the implementation of this application is not limited by the number and arrangement of the electrode units 33 of the electrode sheet 13.

[0048] Each electrode unit 33 can be subjected to an alternating electrical signal, thereby the paired electrode sheets 13 are used to apply an alternating electric field to the tumor site of the patient. Optionally, the electrode unit 33 is a dielectric element, such as a ceramic sheet, or a polymer dielectric layer made of polymer material. Each temperature detection unit 35 is provided corresponding to one electrode unit 33 to detect the temperature at the corresponding electrode unit 33. Each temperature detection unit 35 can be located at any position of the corresponding electrode unit 33. In this embodiment, each electrode unit 35 is located at a position of 100°C.Each electrode unit 33 has a through-hole 331, which is suitable for mounting a temperature detection unit 35. For example, each electrode unit 33 has a through-hole 331 in the middle, and each electrode unit 33's through-hole 331 houses a corresponding temperature detection unit 35. Each temperature detection unit 35 includes a temperature sensor 34 and a diode 36. The temperature sensor 34 has a signal terminal 34-2 and a ground terminal 34-1. The diode 36 has an anode 36-1 and a cathode 36-2. The anode 36-1 of the diode 36 is connected to the ground terminal 34-1 of the temperature sensor 34, and the cathode 36-2 of the diode 36 serves as the ground terminal 35-1 of the temperature detection unit 35. The signal terminal 34-2 of the temperature sensor 34 serves as the signal terminal 35-2 of the temperature detection unit 35. The temperature sensor 34 can be a thermistor or other temperature sensors besides a thermistor. Each temperature sensor 34 corresponds to a diode 36, which is connected in series with the corresponding temperature sensor 34. The diode 36 prevents reverse current flow to avoid the detection signal from other electrode units 33 affecting the temperature sensor 34.

[0049] As shown in FIG3 or FIG4, the electrode sheet 13 of this embodiment includes four grounding wires 18. Each grounding wire 18 is used to ground the grounding terminals 35-1 of the temperature detection units 35 in the same row group. The four grounding wires 18 of the electrode sheet 13 are respectively the first grounding wire 18-1, the second grounding wire 18-2, the third grounding wire 18-3, and the fourth grounding wire 18-4. In the four rows of electrode sheet 13, as per the specification (page 6 / 46, CN 121371479 A), the first row consists of electrode units 33-1 to 33-5, the second row consists of electrode units 33-6 to 33-10, the third row consists of electrode units 33-11 to 33-15, and the fourth row consists of electrode units 33-16 to 33-20. Specifically, the first grounding wire 18-1 is used to ground electrode units 33-1 to 33-5 in the first row; the second grounding wire 18-2 is used to ground electrode units 33-6 to 33-10 in the second row; the third grounding wire 18-3 is used to ground electrode units 33-11 to 33-15 in the third row; and the fourth grounding wire 18-4 is used to ground electrode units 33-16 to 33-20 in the fourth row. It should be noted that these grounding wires 18 can be selectively closed or opened. This can be achieved by connecting each grounding wire 18 in series with a control switch 54. That is, the grounding terminals 35-1 of the temperature detection units 35 corresponding to each electrode unit 33 in each row group are connected to the grounding pin through a control switch 54, which will be described in detail below. The above-mentioned "grounding the electrode unit 33" can refer to grounding the corresponding electrode unit 33.The grounding terminal 34-1 of the temperature sensor 34 is grounded, or the diode 36 is connected in series with the corresponding temperature sensor 34 and grounded together. In short, each grounding wire 18 short-circuits and grounds the grounding terminals 35-1 of the temperature detection units 35 corresponding to all electrode units 33 in each row group.

[0050] As shown in FIG3 or FIG4, the electrode sheet 13 of this embodiment also includes 5 dual-purpose signal lines 19. One end of each dual-purpose signal line 19 is connected to the signal terminal 35-2 of all electrode units 33 and the temperature detection units 35 corresponding to each electrode unit 33 in each column group, and the other end is connected to the adapter 20 for receiving temperature detection signals and transmitting alternating electrical signals. That is, for each row group, each dual-purpose signal line 19 can be connected to one of the electrode units 33 or not connected to any of the electrode units 33 in the row group to avoid the dual-purpose signal line 19 outputting repeated signals in the future. Specifically, the five dual-purpose signal lines 19 of the electrode sheet 13 include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the signal terminals 35-2 of four electrode units 33 (electrode unit 33-1, electrode unit 33-6, electrode unit 33-11, and electrode unit 33-16) and their respective temperature detection units 35; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the signal terminals 35-2 of four electrode units 33 (electrode unit 33-2, electrode unit 33-7, electrode unit 33-12, and electrode unit 33-17) and their respective temperature detection units 35; one end of the third dual-purpose signal line 19-3 is simultaneously connected to the signal terminals 35-2 of electrode unit 33-3. The four electrode units 33 (33-8, 33-13, 33-18) and their corresponding temperature detection units 35 have their signal terminals 35-2 connected simultaneously. One end of the fourth dual-purpose signal line 19-4 is connected to the signal terminals 35-2 of the four electrode units 33 (33-4, 33-9, 33-14, 33-19) and their corresponding temperature detection units 35. One end of the fifth dual-purpose signal line 19-5 is connected to the signal terminals 35-2 of the four electrode units 33 (33-5, 33-10, 33-15, 33-20) and their corresponding temperature detection units 35. In short, each dual-purpose signal line 19 short-circuits the signal terminals 35-2 of each electrode unit 33 and their corresponding temperature detection units 35 in parallel within the same column group for connection to external devices. It should be noted that these dual-purpose signal lines 19 can selectively transmit alternating electrical signals or receive temperature detection signals. This can be achieved by configuring each dual-purpose signal line...Line 19 is connected in series with a bidirectional switching switch 55 and is activated by the closing or opening of the grounding line 18. That is, after the signal terminals 35-2 of each temperature detection unit 35 in each column are shorted to the corresponding electrode unit 33, they are connected to a switching unit (unlabeled) via a dual-purpose signal line 19. This switching unit (unlabeled) includes multiple bidirectional switching switches 55, configured to switch the dual-purpose signal line 19 to either a temperature sampling point (unlabeled) or an alternating power supply line 57. When the dual-purpose signal line 19 is connected to a temperature sampling point (unlabeled), the switching state of the control switch 54 is configured so that the temperature detection signal detected by the corresponding temperature detection unit 35 in each row is sampled based on the temperature sampling point (unlabeled). When the dual-purpose signal line 19 is connected to the alternating power supply line 57, at least one column's electrode unit 33 is subjected to an alternating electrical signal based on the alternating power supply line 57. This will be described in detail below.

[0051] The multi-path grounding line 18 and the multi-path dual-purpose signal line 19 are both conductive traces embedded in the substrate 31. The substrate 31 is electrically connected to the first cable 15. The multi-path grounding line 18 and the multi-path dual-purpose signal line 19 embedded in the substrate 31 are electrically connected to the corresponding wires (not shown) in the first cable 15.

[0052] The tumor electric field therapy system 100 of this embodiment includes at least one pair of the above-mentioned electrode plates 13, an adapter 20 electrically connected to the electrode plates 13, and an electric field generator 30 electrically connected to the adapter 20. The adapter 20 is connected between the electrode plates 13 and the electric field generator 30. The electric field generator 30 provides alternating electrical signals to the multiple electrode units 33 of the electrode plates 13 via the adapter 20 and the dual-purpose signal line 19 of the electrode plates 13, or is used to receive temperature detection signals output by the temperature detection units 35 corresponding to the multiple electrode units 33. The adapter 20 transmits the alternating electrical signal generated by the electric field generator 30 to the dual-purpose signal line 19 of the electrode plate 13, and is also configured to receive the temperature detection signal output by the multiple dual-purpose signal line 19 of the electrode plate 13.

[0053] Referring to Figures 3 and 4, the adapter 20 includes: a first controller 51, multiple sets of ADC units 52 connected to the first controller 51, multiple sets of voltage-reducing resistors 53 and multiple sets of control switches 54 corresponding to the multiple sets of ADC units 52, multiple sets of bidirectional switching switches 55 corresponding to the multiple sets of ADC units 52, a first communication unit 56, an alternating power supply line 57 corresponding to each set of bidirectional switching switches 55, and a first power module 58 connected to the first communication unit 56, the first controller 51, and the multiple sets of ADC units 52. The first power module 58 provides DC power VCC to each electronic component of the adapter 20.The connector 20 also includes multiple circuit lines (unlabeled), which are electrically connected one-to-one to multiple grounding lines 18 and multiple dual-purpose signal lines 19 in the substrate 31 of the corresponding electrode 13 via the first cable 15 of the corresponding electrode 13. The multiple circuit lines (unlabeled) include multiple alternating power lines 57 that transmit alternating electrical signals to the corresponding electrode 13 and are electrically connected to the multiple dual-purpose signal lines 19 in the substrate 31 of the corresponding electrode 13; multiple circuit lines (unlabeled) that are electrically connected one-to-one to the multiple dual-purpose signal lines 19 in the substrate 31 of the corresponding electrode 13 and are used to power each temperature detection unit 35 of the electrode 13 or transmit the temperature detection signal of the electrode 13; and multiple circuit lines (unlabeled) that are electrically connected one-to-one to the multiple grounding lines 18 in the substrate 31 of the corresponding electrode 13. The number L of circuit lines electrically connecting the adapter 20 to one electrode piece 13 is equal to the sum of the number of rows and columns of the electrode units 33 of the electrode piece 13; the number H of circuit lines electrically connecting the adapter 20 to X electrode pieces 13 is equal to X times the number of circuit lines electrically connecting it to a single electrode piece 13, that is, H=XL=X×(M+N). The number of groups of control switches 54 and the number of groups of bidirectional switching switches 55 are related to the number of electrode pieces 13. The number of groups of control switches 54 is the same as the number of groups of bidirectional switching switches 55, and is not less than the number of electrode pieces 13. Optionally, the number of groups of control switches 54 and bidirectional switching switches 55 is the same as the number of electrode pieces 13. The following detailed description only takes the electrical connection of an electrode piece 13 with 20 electrode units 33 to the adapter 20 as an example.

[0054] Each group of control switches 54 is provided with multiple control switches 54. These multiple control switches 54 are respectively connected to the adapter 20 and electrically connected to circuit lines (unlabeled) corresponding to the multiple grounding wires 18 of a corresponding electrode piece 13, and are configured to control the on / off state of the multiple grounding wires 18. The circuit lines (unlabeled) electrically connected to the multiple grounding wires 18 of the electrode piece 13 are grounded at the end closest to the control switch 54. The number of control switches 54 in each group of control switches 54 is related to the number of grounding wires 18 of the substrate 31 of the corresponding electrode piece 13; in this embodiment, the two are equal. As shown in Figure 3 or Figure 4, in this embodiment, the multiple control switches 54 are respectively the first control switch 54-1, the second control switch 54-2, the third control switch 54-3, and the fourth control switch 54-4. The multiple control switches 54 in the same group each control the closing or opening of the corresponding grounding wire 18 of the same electrode piece 13. The first control switch 54-1 is used to control the closing or opening of the first grounding wire 18-1 of the corresponding electrode 13, and can then cooperate with the corresponding bidirectional switching switch 55 to control the first row group 33 of the electrode 13.The five electrode units 33, from 33-1 to 33-5, control the energization and de-energization of the temperature detection units 35 corresponding to each of the five electrode units 33; the second control switch 54-2 is used to control the closing or opening of the second grounding wire 18-2 of the electrode plate 13, and can then cooperate with the corresponding bidirectional switching switch 55 to control the electrode units 33-6 to 33-10 in the second row group 33 of the electrode plate 13. (Instruction manual, page 8 / 46, 11 CN 121371479 A) The third control switch 54-3 controls the energization and de-energization of the temperature detection units 35 corresponding to each electrode unit 33 in the third row group 33 of the electrode plate 13; the third control switch 54-3 controls the opening and closing of the third grounding wire 18-3 of the electrode plate 13, and can cooperate with the corresponding set of bidirectional switching switches 55 to control the energization and de-energization of the temperature detection units 35 corresponding to the five electrode units 33 in the third row group 33 of the electrode plate 13; the fourth control switch 54-4 controls the opening and closing of the fourth grounding wire 18-4 of the electrode plate 13, and can cooperate with the corresponding set of bidirectional switching switches 55 to control the energization and de-energization of the temperature detection units 35 corresponding to the five electrode units 33 in the fourth row group 33 of the electrode plate 13 in the fourth row group 33. The control switches 54 can be mechanical switches, such as relays. The control switches 54 can also be electronic switches, and each control switch 54 can be opened and closed by an additional first controller 51.

[0055] In this embodiment, all sets of control switches 54 are electronic switches. The first controller 51 is communicatively connected to the multiple sets of control switches 54 and is used to sequentially and cyclically control the opening and closing states of multiple control switches 54 in each set of control switches 54, thereby sequentially and individually turning on each grounding wire 18 of the multiple grounding wires 18 of the corresponding electrode 13 and cooperating with the switching of the corresponding bidirectional switching switch 55 to collect the temperature of the patient's body surface detected by all temperature detection units 35 on the electrode 13. The number of each set of control switches 54 is not less than the number of grounding wires 18 of the substrate 31 of the corresponding electrode 13. In this embodiment, the number of each set of control switches 54 is the same as the number of grounding wires 18 of the corresponding electrode 13.

[0056] Each set of bidirectional switching switches 55 is provided with multiple bidirectional switching switches 55. The multiple bidirectional switching switches 55 in each set are respectively connected to the adapter 20 and electrically connected to the circuit lines (unlabeled) corresponding one-to-one with the multi-channel dual-purpose signal lines 19 of the corresponding electrode 13. The number of bidirectional switching switches 55 in each group is related to the number of dual-purpose signal lines 19 on the substrate 31 of the corresponding electrode sheet 13, and is greater than or equal to the number of dual-purpose signal lines 19 on the substrate 31 of the corresponding electrode sheet 13. In this embodiment, the two are equal. Each bidirectional switching switch 55 has a signal acquisition function marked as 1.Terminal 1 and signal input terminal 2 (labeled as 2) are connected to the signal acquisition terminals 1 of multiple bidirectional switching switches 55 in the same group. These terminals are electrically connected to the corresponding detection channels of multiple detection channels in the corresponding group of ADC units 52 through temperature sampling points (unlabeled). The signal input terminal 2 of each bidirectional switching switch 55 in the same group is electrically connected to the corresponding AC power line 57 and is configured to control the multi-channel dual-purpose signal line 19 to connect to the corresponding AC power line 57 to transmit AC electrical signals or to the corresponding detection channel of the corresponding group of ADC units 52 to receive the temperature detection signal output by the temperature detection unit 35.

[0057] As shown in Figure 3 or Figure 4, taking the electrical connection of an electrode plate 13 with the adapter 20 as an example, in this embodiment with 20 electrode units 33, the multiple bidirectional switching switches 55 are respectively the first bidirectional switching switch 55-1, the second bidirectional switching switch 55-2, the third bidirectional switching switch 55-3, the fourth bidirectional switching switch 55-4, and the fifth bidirectional switching switch 55-5. Multiple bidirectional switching switches 55 in the same group control the switching of a corresponding dual-purpose signal line 19 of the same electrode plate 13 between transmitting alternating electrical signals and transmitting temperature detection signals. Specifically, the first bidirectional switching switch 55-1 controls the switching of the first dual-purpose signal line 19-1 of the corresponding electrode plate 13 between transmitting alternating electrical signals and transmitting temperature detection signals, thereby controlling the switching between the conduction of each electrode unit 33 of the electrode units 33-1, 33-6, 33-11, and 33-16 in the first column of the electrode plate 13 and the conduction of the signal terminals 35-2 of the corresponding temperature detection units 35 of the electrode units 33-1, 33-6, 33-11, and 33-16 in the first column, and the corresponding control switch 54-1. Control switches 54-2, 54-3, and 54-4 cooperate to enable the first row of electrode units 33-1, 33-6, 33-11, and 33-16 to transmit alternating electrical signals to the patient or output temperature detection signals collected by the temperature detection units 35 corresponding to these electrode units 33 to the corresponding ADC unit 52; the second bidirectional switch 55-2 is used to control the switching of the second dual-purpose signal line 19-2 of the corresponding electrode pad 13 between transmitting alternating electrical signals and transmitting temperature detection signals, thereby controlling the electrode units 33-2, 33-16, and 33-16 in the second row of electrode pads 13. 7. The conduction of each electrode unit 33 of electrode unit 33-12 and electrode unit 33-17 is connected to the signal terminal 35-2 of each temperature detection unit 35 corresponding to electrode unit 33-7, electrode unit 33-12 and electrode unit 33-17 in the second column group. (Instruction manual, page 9 / 46, CN 121371479 A)The switching between the two is activated and connected to the corresponding control switches 54-1, 54-2, 54-3, and 54-4. The second row of electrode units 33-2, 33-7, 33-12, and 33-17 are coordinated to transmit alternating electrical signals to the patient or output temperature detection signals collected by the temperature detection units 35 corresponding to these electrode units 33 to the corresponding ADC unit 52. A third bidirectional switch 55-3 controls the switching of the third dual-purpose signal line 19-3 of the corresponding electrode pad 13 between transmitting alternating electrical signals and transmitting temperature detection signals. This controls the switching between the conduction of each electrode unit 33 in the third row of electrode units 33-3, 33-8, 33-13, and 33-18 and the conduction of the signal terminals 35-2 of the corresponding temperature detection units in the third row of electrode units 33-3, 33-8, 33-13, and 33-18, and the switching between these two states, and the corresponding control switches 54-1, 54-2, and 54-3. Control switch 54-4, in conjunction with the third column of electrode units 33-3, 33-8, 33-13, and 33-18, enables them to transmit alternating electrical signals to the patient or output temperature detection signals collected by the temperature detection units 35 corresponding to these electrode units 33 to the corresponding ADC unit 52. The fourth bidirectional switching switch 55-4 controls the switching of the fourth dual-purpose signal line 19-4 of the corresponding electrode pad 13 between transmitting alternating electrical signals and transmitting temperature detection signals. This controls the switching between the conduction of each electrode unit 33 in the fourth column of electrode units 33-4, 33-9, 33-14, and 33-19 and the conduction of the signal terminals 35-2 of the corresponding temperature detection units 35 in the fourth column of electrode units 33-4, 33-9, 33-14, and 33-19, and the switching between these two operations, and is also connected to the corresponding control switches 54-1 and 54-2. 2. Control switches 54-3 and 54-4 cooperate to enable the fourth column of electrode units 33-4, 33-9, 33-14, and 33-19 to transmit alternating electrical signals to the patient or output temperature detection signals collected by the temperature detection units 35 corresponding to these electrode units 33 to the corresponding ADC unit 52; the fifth bidirectional switching switch 55-5 is used to control the switching of the fifth dual-purpose signal line 19-5 of the corresponding electrode pad 13 between transmitting alternating electrical signals and transmitting temperature detection signals, thereby controlling the conduction of each electrode unit 33 in the fifth column of electrode units 33-5, 33-10, 33-15, and 33-20 of the electrode pad 13, and the conduction of each electrode unit 33 in the fifth column of electrode units 33-5, 33-10, 33-15, and 33-20 of the electrode pad 13.The signal terminals 35-2 of each temperature detection unit 35 corresponding to unit 33-20 are switched between the two and cooperate with the corresponding control switches 54-1, 54-2, 54-3, and 54-4 to enable the fifth column of electrode units 33-5, 33-10, 33-15, and 33-20 to transmit alternating electrical signals to the patient or output temperature detection signals collected by the temperature detection units 35 corresponding to these electrode units 33 to the corresponding ADC unit 52. When the signal input terminal 2 of each group of bidirectional switching switches 55 is turned on and the signal acquisition terminal 1 is turned off, alternating electrical signals can be transmitted to each electrode unit 33 of the corresponding electrode pad 13. When the signal acquisition terminal 1 of each group of bidirectional switching switches 55 is turned on and the signal input terminal 2 is turned off, it can cooperate with each control switch 54 in the corresponding group of control switches 54 to transmit the temperature detection signals collected by each temperature detection unit 35 on the electrode pad 13 in a time-division manner. The aforementioned bidirectional switching switches 55 can be mechanical switches, such as relays. The bidirectional switching switch 55 can also be an electronic switch, and each bidirectional switching switch 55 can be switched by an additional first controller 51.

[0058] In this embodiment, all of the multiple bidirectional switching switches 55 are electronic switches. The first controller 51 is communicatively connected to the multiple bidirectional switching switches 55 and is used to control the multiple bidirectional switching switches 55 in each group of bidirectional switching switches 55 to switch between their respective signal acquisition terminals 1 and signal input terminals 2, and cooperate with the closing or opening of the corresponding control switch 54 to continuously monitor the temperature of the patient's body surface detected by all temperature detection units 35 on the electrode pad 13 or to transmit alternating electrical signals to the patient.

[0059] In this embodiment, each group of ADC units 52 is electrically connected to the signal acquisition terminals 1 of the multiple bidirectional switching switches 55 in the corresponding group of bidirectional switching switches 55 through multiple circuit lines (unlabeled) in the adapter 20, and is configured to receive the temperature detection signal transmitted by the multi-channel dual-purpose signal line 19 of the corresponding electrode pad 13, and convert the temperature detection signal from an analog signal to a digital signal. Each ADC unit 52 includes multiple detection channels A, B, C, D, and E. Each detection channel A, B, C, D, and E is used to connect to a corresponding dual-purpose signal line 19 in the multi-channel dual-purpose signal line 19 via a corresponding bidirectional switch 55. As shown in Figure 3 or Figure 4, each ADC unit 52 contains a total of 5 detection channels A, B, C, D, and E, which are respectively the first detection channel A, the second detection channel B, the third detection channel C, the fourth detection channel D, and the fifth detection channel E. The first detection channel A is connected to the first dual-purpose signal line 19-1 through the signal acquisition terminal 1 of the first bidirectional switch 55-1, and the second detection channel B is connected to the second dual-purpose signal line 19-1 through the signal acquisition terminal 1 of the first bidirectional switch 55-1.The signal acquisition terminal 1 of the bidirectional switch 55-2 is connected to the second dual-purpose signal line 19-2. The third detection channel C is connected to the third dual-purpose signal line 19-3 through the signal acquisition terminal 1 of the third bidirectional switch 55-3. The fourth detection channel D is connected to the fourth dual-purpose signal line 19-4 through the signal acquisition terminal 1 of the fourth bidirectional switch 55-4. The fifth detection channel E is connected to the fifth dual-purpose signal line 19-5 through the signal acquisition terminal 1 of the fifth bidirectional switch 55-5. Each detection channel A, B, C, D, and E is used to receive the temperature detection signal acquired by the temperature detection unit 35 corresponding to the electrode unit 33 connected to the corresponding dual-purpose signal line 19. In addition, each detection channel A, B, C, D, and E is connected to the first power supply module 58, which provides the detection voltage to the detection channel A, B, C, D, and E, via a corresponding voltage divider resistor 53 in the adapter 20. The first power supply module 58 provides DC power.

[0060] In this embodiment, the first communication unit 56 is configured to acquire digital signals output by multiple ADC units 52 and send the digital signals to the electric field generator 30. The electric field generator 30 is also configured to control and adjust the voltage of the alternating electrical signal provided to the multiple electrode units 33 of the electrode sheet 13 according to the received digital signals. For example, when any of the received digital signals exceeds a preset threshold, it indicates that the temperature detected by the temperature detection unit 35 corresponding to at least one electrode unit 33 in the electrode sheet 13 exceeds the preset temperature threshold (e.g., 41°C, 42°C, etc.). At this time, the voltage of the alternating electrical signal output by the electric field generator 30 can be appropriately reduced to avoid the electrode unit 33 of the electrode sheet 13 from becoming too hot when the alternating electrical signal is applied, causing low-temperature burns to the patient's skin. The aforementioned preset temperature threshold and preset threshold can be determined according to human safety thresholds. The first communication unit 56 is controlled by the first controller 51 and serially transmits the digital signals converted by multiple ADC units 52. In this embodiment, the preset temperature threshold can be a value within the range of 36°C to 45°C.

[0061] Referring to Figures 5 and 6, in this embodiment, the first power module 58 is electrically connected to the second power module 32 of the electric field generator 30 and is configured to supply power to the first controller 51, multiple ADC units 52, and the first communication unit 56 of the adapter 20. Each electrode 13 is connected to the adapter 20 via a first connector 60, which is adapted to connect the corresponding electrode 13 to the adapter 20. As shown in Figure 1, the first connector 60 includes a first plug 61 located at the end of the first cable 15 away from the electrode 13 and a first socket 62 located on the adapter 20. The first plug 61 and the first socket 62 are press-type spring connectors, meaning the first connector 60 connects the adapter 20 to the electrode 13 using a connector method.Each first cable 15 has 5 wires that are electrically connected to the corresponding bidirectional switching switches 55 in the corresponding set of bidirectional switching switches 55, and 4 wires that are electrically connected to the corresponding control switches 54 in the corresponding set of control switches 54. That is, each first connector 60 is electrically connected to the corresponding set of bidirectional switching switches 55 and the corresponding set of control switches 54 of the adapter 20 through 9 wires, and is connected to the electric field generator 30 through the corresponding alternating power line 57 of the adapter 20.

[0062] A second connector 70 is provided between the adapter 20 and the electric field generator 30. The second connector 70 is adapted to connect the electric field generator 30 to the adapter 20. As shown in FIG1, the adapter 20 also includes a second cable 25 connected to the second connector 70. The second connector 70 includes a second plug 71 located at the end of the second cable 25 away from the first controller 51 and a second socket 72 located on the electric field generator 30. The second plug 71 and the second socket 72 are push-button spring connectors, meaning the second connector 70 connects the adapter 20 to the electric field generator 30 using a connector method. Each first connector 60, such as X1, Y1, X2, and Y2, is connected to the second connector 70 via a corresponding alternating power line 57. The first connectors 60, such as X1, Y1, X2, and Y2, are also connected to a corresponding set of control switches 54 and a corresponding set of ADC units 52. Each first connector 60 is connected to the second connector 70 and the corresponding set of ADC units 52 via a corresponding set of bidirectional switching switches 55. The second cable 25 has eight wires, including four wires 1 to 4, each electrically connected to a corresponding alternating power supply line 57 for transmitting alternating electrical signals (see page 11 / 46 of the manual, CN 121371479 A); one wire 5, electrically connected to the data receiving line RX of the first communication unit 56; one wire 6, electrically connected to the data transmitting line TX of the first communication unit 56; one wire 7, electrically connected to the VCC power supply line of the first power module 58; and one wire 8, electrically connected to the GND line of the first power module 58. The second connector 70 is connected to the first communication unit 56 via the data receiving line RX and the data transmitting line TX. The VCC pin of the second connector 70 is connected to the VVC power supply line of the first power module 58, and the GND pin of the second connector 70 is connected to and grounded via the GND line of the first power module 58. The VCC pin of the second connector 70 is also connected to the corresponding group of voltage regulators 53 and the corresponding group of ADC units 52 via the VCC power supply line of the first power module 58.

[0063] Referring to Figures 5 and 7, the electric field generator 30 includes: a second power supply module 32, a second controller 37, an AC signal generator 39, a second communication unit 38, and a set of power supply switches 40. The VCC pin of the second connector 70 is also connected to the second power supply module.The VCC power line of the second power module 32 is electrically connected, and the GND pin of the second connector 70 is grounded through the GND line of the second power module 32. The second power module 32 is also connected to and supplies power to the second controller 37 and the AC signal generator 39, respectively. The second communication unit 38 is electrically connected to the wire 5 of the second connector 70 through its data receiving line RX and to the wire 6 of the second connector 70 through its data transmitting line TX, thereby realizing information interaction between the electric field generator 30 and the adapter 20. The second controller 37 is also electrically connected to the second communication unit 38, the AC signal generator 39, and a set of power switches 40. The second controller 37 is configured to control the opening and closing of each power switch 40 in the set of power switches 40 and adjust the relevant parameters of the alternating electrical signal applied by the AC signal generator 39 according to the relevant digital signals received from the adapter 20 by the second communication unit 38. The AC signal generator 39 is electrically connected to the wires 1 to 4 of the second connector 70 for transmitting alternating electrical signals through a set of power switches 40. A set of power supply switches 40 includes multiple power supply switches 40, each corresponding to a plurality of electrode plates 13. Each power supply switch 40 is electrically connected to a corresponding conductor 1, 2, 3, 4 in the second connector 70 via an AC power line 41-1, 41-2, 41-3, 41-4, and is also electrically connected to a corresponding electrode plate 13 via corresponding conductors 1, 2, 3, 4 in the second connector 70, to deliver an alternating electrical signal to each electrode plate 13. The AC signal generator 39 is electrically connected to this set of power supply switches 40 via multiple AC power lines 41. Specifically, the number of power supply switches 40 in the electric field generator 30 is related to the number of electrode plates 13. In this embodiment, the number of power supply switches 40 is equal to the number of electrode plates 13, and both are four. The power supply switches 40 include a first power supply switch 40-1, a second power supply switch 40-2, a third power supply switch 40-3, and a fourth power supply switch 40-4, which are electrically connected to conductors 1 to 4 of the second connector 70 respectively. One end of the first power supply switch 40-1 is electrically connected to the AC signal generator 39 via the AC power line 41 of the electric field generator 30, and the other end is electrically connected to the corresponding conductor 1 for transmitting alternating electrical signals in the second connection 70 via an AC power line 41-1, and to the AC power line 57 at port X1 of the adapter 20 via the conductor 1 of the second connector 70. The AC power line 57 at port X1 of the adapter 20 is electrically connected to the first connector 60, and the first connector 60 at port X1 of the adapter 20 is electrically connected to the corresponding electrode plate 13, so as to control whether the AC signal generator 39 transmits alternating electrical signals to the electrode plate 13 electrically connected to port X1 of the adapter 20; one end of the second power supply switch 40-2 is electrically connected to the AC signal generator 39 via the AC power line 41 of the electric field generator 30, and the other end is electrically connected to the AC signal generator 39 via an AC power line 41 of the electric field generator 30, and the other end is electrically connected to the AC signal generator 39 via an AC power line 41-1 of the second connection 70, and to the AC signal generator 39 via the AC power line 41 of the electric field generator 30, and the other end is electrically connected to the AC signal generator 39 via the AC power line 41 of the electric field generator 30, and the other end is electrically connected to the AC signal generator 39 via the AC power line 41 of the second connector 70, and ...The AC power line 41-2 is electrically connected to the corresponding conductor 2 transmitting alternating electrical signals in the second connection 70, and is electrically connected to the AC power line 57 located at port Y1 of the adapter 20 via the conductor 2 of the second connector 70. The AC power line 57 located at port Y1 of the adapter 20 is electrically connected to the first connector 60. The first connector 60 located at port Y1 of the adapter 20 is electrically connected to the corresponding electrode plate 13 to control whether the AC signal generator 39 supplies alternating electrical signals to the electrode plate 13 electrically connected to port Y1 of the adapter 20. One end of the third power supply switch 40-3 is connected to the electric field generator. The AC power cord 41 of AC signal generator 30 is electrically connected to AC signal generator 39. The other end is electrically connected to the corresponding conductor 3 for transmitting alternating electrical signals in the second connection 70 via an AC power cord 41-3. It is also electrically connected to the AC power cord 57 at port X2 of adapter 20 via the conductor 3 of the second connector 70. The AC power cord 57 at port X2 of adapter 20 is electrically connected to the first connector 60. The first connector 60 at port X2 of adapter 20 is electrically connected to the corresponding electrode plate 13 to control whether AC signal generator 39 transmits signals to the terminal electrically connected to adapter 20. (Instruction manual 12 / 46) Page 15 CN 121371479 A Electrode 13 at port X2 transmits alternating electrical signals; one end of the fourth power supply switch 40-4 is electrically connected to the AC signal generator 39 via the AC power line 41 of the electric field generator 30, and the other end is electrically connected to the corresponding wire 4 in the second connection 70 via an AC power line 41-4, and is electrically connected to the alternating power line 57 at port Y2 of the adapter 20 via the wire 4 of the second connector 70, the alternating power line 57 at port Y2 of the adapter 20 is electrically connected to the first connector 60, and the first connector 60 at port Y2 of the adapter 20 is electrically connected to the corresponding electrode 13, so as to control whether the AC signal generator 39 transmits alternating electrical signals to the electrode 13 electrically connected to port Y1 of the adapter 20.

[0064] The working principle of the tumor electric field therapy system 100 of this embodiment will be described in detail below with reference to Figures 3 to 5.

[0065] Specifically, when it is necessary to detect the temperature at each electrode unit 33 of an electrode plate 13, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controls each of the multiple bidirectional switching switches 55 electrically connected to the electrode plate 13 to turn on the signal acquisition terminal 1 and turn off the signal input terminal 2, so as to disconnect the alternating electrical signal applied to the electrode plate 13; at the same time, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controls each of the control switches 54 electrically connected to the electrode plate 13 to turn on sequentially and time-divisionally. At this time, the multiple detection channels A, B, C, D, E of the ADC unit 52 corresponding to the electrode plate 13 can be used.The temperature detection signals are collected sequentially and in a time-division manner from the temperature detection units 35 corresponding to each electrode unit 33 in each row of the electrode plate 13. Each detection channel A, B, C, D, and E of each ADC unit 52 group simultaneously collects only the temperature detection signals from the temperature detection units 35 corresponding to each electrode unit 33 in the same row of the electrode plate 13. These temperature detection signals can be characterized by voltage values. Only one of the four control switches 54 in the group corresponding to the electrode plate 13 can be turned on at any given time, while the other three are turned off. All five bidirectional switching switches 55 in the group corresponding to the ADC unit 52 are switched to their respective signal acquisition terminals 1, so that each dual-purpose signal line 19 of the electrode plate 13 is electrically connected to the corresponding detection channels A, B, C, D, and E of the corresponding ADC unit 52. With this configuration, the ADC unit 52 can collect the voltage values ​​of all temperature detection units 35 corresponding to each electrode unit 33 in the same row of the electrode plate 13 that are shorted by a grounding wire 18 corresponding to the turned-on control switch 54.

[0066] Specifically, when control switch 54-1 is closed, control switches 54-2, 54-3, and 54-4 are all open, and the first bidirectional switching switch 55-1, the second bidirectional switching switch 55-2, the third bidirectional switching switch 55-3, the fourth bidirectional switching switch 55-4, and the fifth bidirectional switching switch 55-5 are all switched to their respective signal acquisition terminals 1, the temperature detection units 35 corresponding to electrode units 33-1 to 33-5 in the first row group are energized, and the temperature detection units 35 corresponding to electrode units 33-6 to 33-20 in the remaining row groups are de-energized. Electrode units 33 are short-circuited on the first detection channel A of the ADC unit 52 in that group. -1. The signal terminals 35-2 of the temperature detection units 35 corresponding to electrode units 33-6, 33-11, and 33-16 are grounded only because the ground terminal 35-1 of the temperature detection unit 35 corresponding to electrode unit 33-1 is connected, while the ground terminals 35-1 of the temperature detection units 35 corresponding to electrode units 33-6, 33-11, and 33-16 are disconnected. Furthermore, each temperature detection unit 35 includes a temperature sensor 34 and a diode 36 connected in series with the temperature sensor 34, which does not affect the resistance value of the temperature detection unit 35 corresponding to electrode unit 33-1. Therefore, only the temperature detection unit 35 corresponding to electrode unit 33-1 is effectively operating on the first detection channel A of this ADC unit 52. The temperature detection signal (voltage value) acquired by the first detection channel A is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-1. Similarly, the voltage value acquired on the second detection channel B of this ADC unit 52 is the voltage of the temperature detection unit 35 corresponding to electrode unit 33-2.The voltage value acquired on the third detection channel C of this ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-3. The voltage value acquired on the fourth detection channel D of this ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-4. The voltage value acquired on the fifth detection channel E of this ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-5. Instruction manual, page 13 / 46, 16 CN 121371479 A

[0067] When control switch 54-2 is closed, control switches 54-1, 54-3, and 54-4 are all open, and the first bidirectional switching switch 55-1, the second bidirectional switching switch 55-2, the third bidirectional switching switch 55-3, the fourth bidirectional switching switch 55-4, and the fifth bidirectional switching switch 55-5 are all switched to their respective signal acquisition terminals 1, the temperature detection units 35 corresponding to electrode units 33-6 to 33-10 of the second row group are energized, and the temperature detection units 35 corresponding to electrode units 33-1 to 33-5 and electrode units 33-11 to 33-20 of the other row groups are de-energized, and the ADC unit 52 of this group is de-energized. In the first detection channel A, the signal terminals 35-2 of the temperature detection units 35 corresponding to electrode units 33-1, 33-6, 33-11, and 33-16 are shorted. Since only the ground terminal 35-1 of the temperature detection unit 35 corresponding to electrode unit 33-6 is grounded, while the ground terminals 35-1 of the temperature detection units 35 corresponding to electrode units 33-1, 33-11, and 33-16 are open, and each temperature detection unit 35 includes a temperature sensor 34 and a diode 36 connected in series with the temperature sensor 34, it will not affect the resistance value of the temperature detection unit 35 corresponding to electrode unit 33-6. Therefore, only the temperature detection unit 35 corresponding to electrode unit 33-6 is effectively working on the first detection channel A of this ADC unit 52. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-6. Similarly, the voltage value acquired on the second detection channel B in this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-7. The voltage value acquired on the third detection channel C in this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-8. The voltage value acquired on the fourth detection channel D in this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-9. The voltage value acquired on the fifth detection channel E in this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-10.

[0068] When control switch 54-3 is closed, and control switches 54-1, 54-2, and 54-4 are all open, and the first bidirectional switch 55-1, the second bidirectional switch 55-2, the third bidirectional switch 55-3, the fourth bidirectional switch 55-4, and the fifth bidirectional switch 55-5 are all switched to their respective signal acquisition terminals 1, the temperature detection units 35 corresponding to electrode units 33-11 to 33-15 in the third row group are energized, while the temperature detection units 35 corresponding to electrode units 33-11 to 33-10 and electrode units 33-16 to 33-20 in the other rows are de-energized. The ADC unit 52 in this group... In the first detection channel A, the signal terminals 35-2 of the temperature detection units 35 corresponding to electrode units 33-1, 33-6, 33-11, and 33-16 are shorted. Since only the ground terminal 35-1 of the temperature detection unit 35 corresponding to electrode unit 33-11 is grounded, while the ground terminals 35-1 of the temperature detection units 35 corresponding to electrode units 33-1, 33-6, and 33-16 are open, and each temperature detection unit 35 includes a temperature sensor 34 and a diode 36 connected in series with the temperature sensor 34, it will not affect the resistance value of the temperature detection unit 35 corresponding to electrode unit 33-11. Therefore, only the temperature detection unit 35 corresponding to electrode unit 33-11 is effectively operating on the first detection channel A of this ADC unit 52. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-11. Similarly, the voltage value acquired on the second detection channel B in this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-12. The voltage value acquired on the third detection channel C in this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-13. The voltage value acquired on the fourth detection channel D in this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-14. The voltage value acquired on the fifth detection channel E in this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-15.

[0069] When control switch 54-4 is closed, control switches 54-1, 54-2, and 54-3 are all open, and the first bidirectional switching switch 55-1, the second bidirectional switching switch 55-2, the third bidirectional switching switch 55-3, the fourth bidirectional switching switch 55-4, and the fifth bidirectional switching switch 55-5 are all switched to their respective signal acquisition terminals 1. The temperature detection units 35 corresponding to electrode units 33-16 to 33-20 in the fourth row group are energized, and the electrode units 33-1 to 33-20 in the remaining rows are energized. (Instruction manual 14 / 46 pages 17 CN)When the temperature detection units 35 corresponding to 121371479 A 15 are de-energized, the signal terminals 35-2 of the temperature detection units 35 corresponding to electrode units 33-1, 33-6, 33-11, and 33-16 in the first detection channel A of this group of ADC units 52 are shorted. Since only the grounding terminal 35-1 of the temperature detection unit 35 corresponding to electrode unit 33-16 is grounded, while the grounding terminals 35-1 of the temperature detection units 35 corresponding to electrode units 33-1, 33-6, and 33-11 are all disconnected, and each temperature detection unit 35 includes a temperature sensor 34 and a diode 36 connected in series with the temperature sensor 34, the resistance value of the temperature detection unit 35 corresponding to electrode unit 33-16 will not be affected. Therefore, only the temperature detection unit 35 corresponding to electrode unit 33-16 is effectively operating on the first detection channel A of this group of ADC units 52. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-16. Similarly, the voltage value collected on the second detection channel B of this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-17. The voltage value collected on the third detection channel C in this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-18. The voltage value collected on the fourth detection channel D in this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-19. The voltage value collected on the fifth detection channel E in this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-20.

[0070] Thus, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 can collect the temperature detection signals of the temperature detection units 35 corresponding to all electrode units 33 of the electrode 13 by controlling a set of bidirectional switching switches 55 and a set of control switches 54 that are electrically connected to a certain electrode plate 13. That is, the switching unit (unlabeled) is configured to switch the dual-purpose signal lines 19 corresponding to at least two column groups to be connected to the corresponding temperature sampling points (unlabeled) at the same time, and the switching state of the corresponding control switch 54 is configured so that the temperature detection signal detected by the corresponding temperature detection unit 35 in each row group is sampled based on the corresponding temperature sampling point (unlabeled). Similarly, the temperature detection signals of the temperature detection units 35 corresponding to each electrode unit 33 of other electrode sheets 13 can be obtained.

[0071] The first controller 51 or the second controller 37, multiple ADC units 52 and multiple bidirectional switching switches 55 can be automatically executed by pre-programmed program code. For example, the first controller 51 or the second controller 37 first controls the corresponding groupAll bidirectional switches 55 in the bidirectional switching switches 55 are switched to signal acquisition terminals 1, making all signal acquisition terminals 1 of these bidirectional switching switches 55 conductive and all signal input terminals 2 disconnected, so that each dual-purpose signal line 19 of the corresponding electrode plate 13 is electrically connected to the corresponding group of ADC units 52. Then, control switch 54-1 in the corresponding group of control switches 54 is closed, and the remaining control switches 54-2 to 54-4 in the group of control switches 54 are opened. During this period, each detection channel A, B, C, D, and E of the group of ADC units 52 acquires the temperature detection signals of each temperature detection unit 35 corresponding to each electrode unit 33 in the first row of the corresponding electrode plate 13, converts them into digital signals, and stores them in a separately set memory. Then, after a preset interval, The first controller 51 or the second controller 37 then closes control switch 54-2 in the group of control switches 54, and opens control switches 54-1, 54-3 and 54-4 in the group of control switches 54. During this period, each detection channel A, B, C, D and E of the ADC unit 52 acquires the temperature detection signal of each temperature detection unit 35 corresponding to each electrode unit 33 in the second row group. By sequentially turning on each control switch 54 in the group of control switches 54, the temperature detection signal of all temperature detection units 35 on the electrode plate 13 can be obtained. Similarly, the temperature detection signals of all temperature detection units 35 on at least one pair of electrode plates 13 can be obtained through this operation.

[0072] It should be noted that in some other embodiments, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 can also control a group of bidirectional switching switches 55 and a group of control switches 54 electrically connected to a certain electrode plate 13 to acquire the temperature detection signals of the temperature detection units 35 corresponding to some electrode units 33 of the electrode plate 13 during the same temperature acquisition time period. For example, when only the first bidirectional switching switch 55-1 is switched to its signal acquisition terminal 1, the control switch 54-1 can be closed first, and the control switches 54-2, 54-3, and 54-4 can all be opened. At this time, only the temperature detection unit 35 corresponding to the electrode unit 33-1 of the first row group is energized. The signal terminal 35-2 of the temperature detection unit 35 corresponding to the electrode unit 33-1 is short-circuited on the first detection channel A of the ADC unit 52 of this group. Therefore, the ADC unit 52 of this group will detect the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-1. Then, the control switch 54-2 is closed, and the control switches 54-1, 54-3, and 54-4 are all opened. At this time, the ADC unit 52 of this group will detect the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-6. Then, the control switch 54-3 is closed, and the control switches 54-1, 54-2, and 54-4 are all opened.When switches 54-4 are all open, the ADC unit 52 in this group will detect the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-11. Finally, control switch 54-4 is closed, and control switches 54-1, 54-2, and 54-3 are all open. At this time, the ADC unit 52 in this group will detect the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-16. Thus, within the same acquisition time period, only the temperature detection signal of the temperature detection unit 35 corresponding to one column of electrode units 33 can be sampled. Similarly, the temperature detection signals of the temperature detection units 35 corresponding to other columns of electrode units 33 can be sampled in other acquisition time periods. That is, the switching unit (unlabeled) is configured to switch the dual-purpose signal line 19 corresponding to each column group to the corresponding temperature sampling point (unlabeled), and the switching state of control switch 54 is configured so that the temperature detection signal detected by each temperature detection unit 35 in each column group is sampled separately. It should be noted that in some other embodiments, the temperature detection signals of the temperature detection units 35 corresponding to the two, three, or four groups of electrode units 33 can also be sampled within the same acquisition time period. The specific details will not be elaborated here.

[0073] Specifically, when it is necessary to apply an alternating electrical signal to each electrode unit 33 of a certain electrode plate 13, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controls the signal input terminal 2 of each of the multiple bidirectional switching switches 55 electrically connected to the electrode plate 13 to be turned on and the signal acquisition terminal 1 to be turned off, and controls a power supply switch 40 electrically connected to the electrode plate 13 to be turned on. At this time, the second controller 37 of the electric field generator 30 controls the AC signal generator 39 to apply an alternating electrical signal to each electrode unit 33 of the electrode plate 13 through the alternating power line 57, and the magnitude of the applied alternating electrical signal voltage or current is adjustable. That is, the switching unit (unlabeled) is configured to simultaneously connect the dual-purpose signal lines 19 corresponding to at least two column groups to the alternating power supply line 57, so that the electrode units 33 of at least two column groups are simultaneously subjected to alternating electrical signals based on the alternating power supply line 57.

[0074] It should be noted that, in some other embodiments, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 can also control a group of bidirectional switching switches 55 electrically connected to a certain electrode piece 13 to apply alternating electrical signals to some electrode units 33 of the electrode piece 13 in the same time period. For example, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controls the signal input terminal 2 of the first bidirectional switching switch 55-1 of a group of bidirectional switching switches 55 electrically connected to the electrode piece 13 to be turned on and the signal acquisition terminal 1 to be turned off, and controls the signal input terminal 2 of the first bidirectional switching switch 55-1 to be turned on and the signal acquisition terminal 1 to be turned off.A power switch 40 electrically connected to the electrode 13 is turned on. At this time, the second controller 37 of the electric field generator 30 controls the AC signal generator 39 to apply alternating electrical signals to the first column of electrode units 33-1, 33-6, 33-11, and 33-16 of the electrode 13 through the alternating power line 57. The voltage or current of the applied alternating electrical signal is adjustable. That is, the switching unit (unlabeled) is configured to switch the dual-purpose signal line 19 corresponding to each column to the alternating power line 57, so that the electrode units 33 of each column are simultaneously applied alternating electrical signals based on the alternating power line 57. It should be noted that in some other embodiments, alternating electrical signals can also be applied to two, three, or four columns of electrode units 33 simultaneously within the same time period, which will not be described in detail here.

[0075] It should be noted that in this embodiment, the control switch 54, which is electrically connected to each of the multiple grounding lines 18 of the electrode plate 13, and the bidirectional switching switch 55, which is electrically connected to each of the multiple dual-purpose signal lines 19 of the electrode plate 13, are both located in the adapter 20. However, in other embodiments, the control switch 54, which is electrically connected to the grounding line 18, and the bidirectional switching switch 55, which is electrically connected to the dual-purpose signal line 19, may also be located on the electrode plate 13 or in the electric field generator 30. This will not be described again here. In addition, the ADC unit 52 located in the adapter 20 may also be located in the electric field generator 30 and directly controlled by the second controller 37.

[0076] The tumor electric field therapy system 100 of this application can achieve real-time and comprehensive monitoring of the temperature of all electrode units 33 on the electrode sheet 13 without increasing the weight of the electrode sheet 13 or the number of wire cores of the first cable 15 electrically connected to the electrode sheet 13. It can then determine whether the electrode sheet 13 is qualified based on the obtained temperature detection signal; or determine whether the temperature detection unit 35 of the electrode sheet 13 is faulty or abnormal based on the obtained temperature detection signal, and determine whether the electrode sheet 13 needs to be replaced based on the number of faulty or abnormal temperature detection units 35; or identify the electrode sheet type based on the obtained temperature detection signal if the electrode sheet is qualified; or determine whether the electrode unit 33 of the electrode sheet 13 is overheated based on the obtained temperature detection signal if the electrode sheet is qualified, and then control the alternating electrical signal applied to the electrode sheet 13 or the corresponding column of electrode units 33 of the electrode sheet 13, so as to avoid low-temperature burns to the patient's body surface when tumor treatment is performed through the electrode sheet 13. Furthermore, the substrate 31 of the electrode sheet 13 in this application is simultaneously electrically connected to the same electrode unit 33 and its corresponding temperature via the same dual-purpose signal line 19.The signal terminal 35-2 of the detection unit 35, while enabling the transmission of both alternating current signals and DC signals for temperature signal acquisition via the dual-purpose signal line 19, significantly reduces the number of conductive traces (grounding line 18, dual-purpose signal line 19) laid on it, thereby reducing the wiring difficulty of the substrate 31, simplifying the manufacturing process, reducing the weight of the substrate 31, and lowering manufacturing costs. The electrode sheet 13 of this application can also switch between applying alternating current signals for tumor treatment and transmitting DC signals for temperature acquisition and transmitting the acquired temperature detection signals through a combination of control switch 54 electrically connected to its grounding line 18 and bidirectional switching switch 55 electrically connected to the dual-purpose signal line 19.

[0077] Specifically, when it is necessary to apply alternating electrical signals to the patient through each electrode unit 33 of a certain electrode pad 13, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controls all the control switches 54 in a set of control switches 54 corresponding to the electrode pad 13 to be disconnected, and at the same time controls all the bidirectional switching switches 55 in a set of bidirectional switching switches 55 corresponding to the electrode pad 13 to be switched to their respective signal input terminals 2, so that the signal acquisition terminals 1 of these bidirectional switching switches 55 are all disconnected and the signal input terminals 2 are all turned on, so that each dual-purpose signal line 19 of the electrode pad 13 is electrically connected to an alternating power supply line 57 corresponding to the electrode pad 13 of the adapter 20, thereby transmitting the alternating electrical signals to each electrode unit 33 of the electrode pad 13. When the temperature detection signals of the temperature detection units 35 corresponding to all electrode units 33 of the detected electrode plate 13 are much lower than the preset temperature threshold stored in the electric field generator 30 or the adapter 20, the electric field generator 30 controls the AC signal generator 39 through its second controller 37 to continue generating alternating electrical signals with increased voltage or current amplitude, or with constant voltage or current amplitude, and then transmits them to the corresponding counter electrode plate 13 through a corresponding alternating power line 57 of the adapter 20, so that the counter electrode plate 13 continues to be applied with alternating electrical signals; when the temperature detection signals of the temperature detection units 35 corresponding to all electrode units 33 of the detected electrode plate 13 are lower than but close to the preset temperature threshold stored in the electric field generator 30 or the adapter 20, the electric field generator 30 can reduce the voltage or current of the alternating electrical signal generated by the AC signal generator 39 through the second controller 37, thereby reducing the voltage or current of the alternating electrical signal applied to the counter electrode plate 13; when a certain electrode plate 13 is detected When the temperature detection signal of the temperature detection unit 35 corresponding to an electrode unit 33 exceeds a preset temperature threshold, the electric field generator 30 controls the power supply switch 40 electrically connected to the electrode 13 to disconnect via the second controller 37, thereby stopping the application of alternating electrical signals to the electrode 13; or the second controller 37 of the electric field generator 30 or the first controller 21 of the adapter 20 controls the power supply switch 40 electrically connected to the electrode 13 to disconnect.All bidirectional switching switches 55 in a set of bidirectional switching switches 55 electrically connected to electrode 13 switch from their signal input terminal 2 to their signal acquisition terminal 1. That is, all signal acquisition terminals 1 of all bidirectional switching switches 55 in a set of bidirectional switching switches 55 electrically connected to electrode 13 are turned on and all signal input terminals 2 are turned off, thereby stopping the application of alternating electrical signals to electrode 13; (Instruction manual 17 / 46 pages 20 CN 121371479 A) Or, when the temperature detection signal of a temperature detection unit 35 corresponding to an electrode unit 33 of a certain electrode 13 is detected to be greater than a preset temperature threshold, the second controller 37 of the electric field generator 30 controls the power supply switch 40 electrically connected to the electrode 13 to continue to be turned on, and the second controller 37 of the electric field generator 30 or the first controller 21 of the adapter 20 controls a bidirectional switching switch 55 electrically connected to the electrode unit 33 of the electrode 13 to switch from its signal input terminal 2 to its signal acquisition terminal 1, and the second controller 37 of the electric field generator 30 or the first controller 21 of the adapter 20 controls a bidirectional switching switch 55 electrically connected to the electrode unit 33 of the electrode 13 to switch from its signal input terminal 2 to its signal acquisition terminal 1, and the second controller 37 of the electric field generator 30 or the first controller 21 of the adapter 20... The controller 21 simultaneously controls the remaining bidirectional switching switches 55 that are electrically connected to the electrode units 33 in different columns from the electrode units 33 whose temperature detection signals exceed the preset temperature threshold, so that they continue to be electrically connected to their respective signal input terminals 2, thereby stopping the application of alternating electrical signals to all electrode units 33 in the column where the temperature detection signals of the electrode unit 33 exceed the preset temperature threshold, and continuing to apply alternating electrical signals to the remaining columns of electrode units 33 whose temperature detection signals of the electrode unit 13 do not exceed the preset temperature threshold. This realizes the alternating electrical signal application control method of the tumor electric field therapy system 100 based on the temperature detection signal.

[0078] The present application embodiment provides an electrode temperature detection method, applied to the electrode unit 13 or the tumor electric field therapy system 100 described above. Referring to FIG8, it includes the following steps:

[0079] Step 210: Control the switching unit so that the dual-purpose signal line 19 corresponding to at least one column group in the corresponding electrode unit 13 is connected to the corresponding temperature sampling point.

[0080] Specifically, the bidirectional switching switch 55 electrically connected to each electrode unit 33 of the electrode sheet 13 is controlled to disconnect the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13, and simultaneously connect the DC electrical signal applied to the signal terminal 35-2 of the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode sheet 13.

[0081] Further, the bidirectional switching switch 55 electrically connected to each electrode unit 33 of the electrode sheet 13 is controlled to switch from its end electrically connected to the alternating electrical signal to its end electrically connected to the DC electrical signal, that is, the bidirectional switching switch 55 electrically connected to the electrode sheet 13 is controlled to switch from its signal input terminal 2 to its signal acquisition terminal 1; or, the bidirectional switching switch 55 electrically connected to each electrode unit 33 of the electrode sheet 13 is controlled to switch from its signal input terminal 2 to its signal acquisition terminal 1; or, the bidirectional switching switch 55 electrically connected to each electrode unit 33 of the electrode sheet 13 is controlled to switch from its signal input terminal 2 to its signal acquisition terminal 1.The bidirectional switching switch 55 electrically connected to the electrode unit 33 of the electrode sheet 13 switches from the on state to the off state, and at the same time switches the signal terminal 35-2 of the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode sheet 13 from the off state to the on state.

[0082] Step 220: Control the control switch 54 corresponding to each row group so as to sample the analog temperature signal of the corresponding electrode unit 33 based on the corresponding temperature sampling point.

[0083] Specifically, the control switch 54 electrically connected to the ground terminal 35-1 of the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode sheet 13 is turned on in a time-sequential manner to obtain the temperature detection signal of the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode sheet 13.

[0084] In some embodiments, when the dual-use signal line 19 corresponding to each column group is connected to the corresponding temperature sampling point, controlling the control switch 54 corresponding to each row group includes: controlling the control switch 54 corresponding to each row group to close sequentially so as to sample the analog temperature signal of each electrode unit 33 in each column group.

[0085] In some other embodiments, when at least two column groups of dual-purpose signal lines 19 are simultaneously connected to the corresponding temperature sampling points, the control switch 54 corresponding to each row group is controlled, including: controlling the control switch 54 corresponding to each row group to close sequentially, so as to sample the analog temperature signal of the corresponding electrode unit 33 in each row group respectively.

[0086] The electrode sheet temperature detection method of this application can quickly and accurately obtain the temperature of all electrode units of the electrode sheet; and can determine whether the temperature detection unit of the electrode sheet is faulty, abnormal, or whether the electrode sheet is qualified and needs to be replaced based on the obtained temperature detection signals of all temperature detection units of the electrode sheet; it can also determine whether each electrode unit of the electrode sheet is overheated based on the obtained temperature detection signals of all temperature detection units of the electrode sheet (page 18 / 46, CN 121371479 A) and then control the alternating electrical signal applied to the electrode sheet or each electrode unit of the electrode sheet; it can also identify the electrode sheet type when the temperature detection signals of each temperature detection unit of the electrode sheet are normal.

[0087] In the tumor electric field therapy system 100 of this application embodiment, the first controller 51 or electric field generator 30 in the adapter 20 is provided with a preset threshold, a first preset temperature, a second preset temperature and a preset temperature threshold, wherein the first preset temperature is lower than the second preset temperature and the second preset temperature is lower than the preset temperature threshold.

[0088] Referring to FIG9, this application also provides an electrode sheet temperature abnormality detection method, which includes the following steps:

[0089] Step 210: Control the switching unit to make at least one column group of the corresponding electrode sheet 13 corresponding to the dual-useSignal line 19 is connected to the corresponding temperature sampling point.

[0090] Step 220: Control the control switch 54 corresponding to each row group so as to sample the analog temperature signal of the corresponding electrode unit 33 based on the corresponding temperature sampling point, so as to determine the temperature detection signal at each electrode unit 33 in each electrode sheet 13.

[0091] Step 230: Determine whether the electrode sheet 13 is abnormal based on the temperature detection signal.

[0092] In some embodiments, step 230, determining whether the electrode sheet 13 is abnormal based on the temperature detection signal, specifically includes the following steps:

[0093] Step 231: Compare the temperature at each electrode unit 33 in the corresponding electrode sheet 13 with a preset temperature threshold based on the temperature detection signal. Specifically, the temperature detection signal detected by the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 can be compared with the preset temperature threshold.

[0094] Step 232: Determine whether the temperature of the electrode sheet 13 is abnormal based on the comparison result. Specifically, determine whether there is a temperature abnormality in each electrode unit 33 in the electrode sheet 13 based on the comparison result.

[0095] The comparison results in step 232 include not exceeding the preset temperature threshold and exceeding the preset temperature threshold. Not exceeding the preset temperature threshold includes being much lower than the preset temperature threshold and being close to the preset temperature threshold. The preset temperature threshold is 40℃-42℃. Optionally, the preset temperature threshold is 40.5℃-41.5℃. Optionally, the preset temperature threshold is 41℃-41.5℃. Optionally, the preset temperature threshold is 41℃.

[0096] The process of determining whether the temperature of the electrode sheet 13 is abnormal based on the comparison results in step 232 is as follows: if the temperature at any electrode unit 33 in the corresponding electrode sheet 13 exceeds the preset temperature threshold, it is determined that the temperature of the electrode sheet 13 is abnormal. If the temperature at all electrode units 33 in the corresponding electrode sheet 13 does not exceed the preset temperature threshold, it is determined that the temperature of the electrode sheet 13 is not abnormal.

[0097] In some other embodiments, step 230, determining whether the electrode sheet 13 is abnormal based on the temperature detection signal, specifically includes the following steps:

[0098] Step 233: If any electrode unit 33 in the corresponding electrode sheet 13 is found to be abnormal or malfunctioning based on the temperature detection signal, the electrode sheet 13 is determined to be unqualified.

[0099] Specifically, the temperature detection signal detected by the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 is used to determine whether the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 is abnormal or malfunctioning; then, the electrode sheet 13 is determined to be qualified based on whether the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 is abnormal or malfunctioning. Wherein, when the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 is abnormal or malfunctioning...When the element 35 is abnormal or malfunctioning, the electrode sheet 13 is deemed unqualified; when the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 is not abnormal or malfunctioning, the electrode sheet 13 is deemed qualified.

[0100] In some other embodiments, the step 230 of determining whether the electrode sheet 13 is abnormal based on the temperature detection signal specifically includes the following steps:

[0101] Step 234: If it is determined that there is an abnormal or malfunctioning electrode unit 33 in the corresponding electrode sheet 13 based on the temperature detection signal, the number of abnormal or malfunctioning electrode units 33 is determined.

[0102] Step 235: If the number of abnormal or malfunctioning electrode units 33 reaches a preset threshold, the electrode sheet 13 is determined to need to be replaced.

[0103] Specifically, based on the temperature detection signals of the temperature detection units 35 corresponding to each electrode unit 33 in the electrode sheet 13, it is determined whether the temperature detection units 35 corresponding to each electrode unit 33 in the electrode sheet 13 are abnormal or faulty; then, based on whether the temperature detection units 35 corresponding to each electrode unit 33 in the electrode sheet 13 are abnormal or faulty, it is determined whether the electrode sheet 13 needs to be replaced.

[0104] For example, when the temperature detection units 35 corresponding to each electrode unit 33 in the electrode sheet 13 are abnormal or faulty and the number of abnormal or faulty temperature detection units 35 exceeds a preset threshold, it is determined that the electrode sheet 13 needs to be replaced; when the number of abnormal or faulty temperature detection units 35 in the electrode sheet 13 does not exceed the preset threshold, it is determined that the electrode sheet 13 does not need to be replaced. The preset threshold is 20% of the total number of temperature detection units 35 in the electrode sheet 13.

[0105] Referring to FIG10, this application also provides a control method for a tumor electric field therapy system, which includes the following steps:

[0106] Step 210: Controlling the switching unit to connect the dual-purpose signal line 19 corresponding to at least one column group in the corresponding electrode sheet 13 to the corresponding temperature sampling point.

[0107] Step 220: Controlling the control switch 54 corresponding to each row group to sample the analog temperature signal of the corresponding electrode unit 33 based on the corresponding temperature sampling point to determine the temperature detection signal of each electrode unit 33 in each electrode sheet 13.

[0108] Step 240: Controlling the intensity of the alternating electrical signal applied to the electrode unit 33 according to the temperature detection signal.

[0109] Specifically, when it is determined that the electrode sheet 13 does not need to be replaced, the alternating electrical signal applied to each electrode unit 33 in the electrode sheet 13 is controlled or adjusted according to the temperature detection signal detected by the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13. In other words, steps 234-235 can be added between steps 240 and 220.

[0110] In some embodiments, controlling the intensity of the alternating electrical signal applied to the electrode unit 33 based on the temperature detection signal in step 240 specifically includes the following steps:

[0111] Step 241: Compare the temperature at each electrode unit 33 in the electrode sheet 13 with a preset temperature threshold based on the temperature detection signal.

[0112] Step 242: Control the intensity of the alternating electrical signal based on the comparison result.

[0113] In some embodiments, controlling the intensity of the alternating electrical signal based on the comparison result in step 242 specifically includes:

[0114] Step 2421: If the temperature at at least one electrode unit 33 exceeds the preset temperature threshold, stop applying the alternating electrical signal to the electrode unit 33 of the electrode sheet 13. Specifically, when any temperature detection signal among the acquired temperature detection signals of all electrode units 33 of the electrode sheet 13 exceeds the preset temperature threshold, stop applying the alternating electrical signal to the electrode unit 33 of the electrode sheet 13. When the temperature detection signals of each electrode unit 33 in the electrode sheet 13 do not exceed the preset temperature threshold, alternating electrical signals continue to be applied to each electrode unit 33 in the electrode sheet 13.

[0115] In some embodiments, stopping the application of alternating electrical signals to the electrode units 33 in the electrode sheet 13 in step 2421 specifically includes: stopping the application of alternating electrical signals to all electrode units 33 in the electrode sheet 13; or stopping the application of alternating electrical signals to all electrode units 33 in the column group of electrode units 33 in the electrode sheet 13 that exceed the preset temperature threshold.

[0116] Further, when the application of alternating electrical signals to all electrode units 33 in the column group of electrode units 33 in the electrode sheet 13 that exceed the preset temperature threshold is stopped, alternating electrical signals continue to be applied to the electrode units 33 in other columns in the electrode sheet 13. The intensity of the alternating electrical signals applied to the electrode units 33 in other columns in the electrode sheet 13 is adjustable. For example, all electrode units 33 in electrode sheet 13 whose temperature detection signal does not exceed a preset temperature threshold and are in different columns from electrode units 33 whose temperature detection signal exceeds the preset temperature threshold are continuously subjected to an alternating electrical signal, and this signal is adjustable.

[0117] In some other embodiments, controlling the alternating electrical signal intensity based on the comparison result in step 242 specifically includes:

[0118] Step 2422: If the temperature at all electrode units 33 in electrode sheet 13 does not exceed a preset temperature threshold, and if the temperature at all electrode units 33 in electrode sheet 13 does not exceed a first preset temperature, then the alternating electrical signal intensity applied to the electrode units 33 of electrode sheet 13 is increased, wherein the first preset temperature is less than the preset temperature threshold.

[0119] In step 2422, the electric field intensity increases by the same amount for each column group whose alternating electrical signal intensity is increased.

[0120] Step 2423: If the temperature at all electrode units 33 in the electrode sheet 13 does not exceed the preset temperature threshold, and if the temperature at at least one electrode unit 33 in the electrode sheet 13 exceeds the first preset temperature but is less than the second preset temperature, then the alternating electrical signal intensity currently applied to the electrode unit 33 of the electrode sheet 13 remains unchanged.

[0121] Step 2424: If the temperature at all electrode units 33 in the electrode sheet 13 does not exceed the preset temperature threshold, and if the temperature at at least one electrode unit 33 in the electrode sheet 13 exceeds the second preset temperature but is less than the preset temperature threshold, then the alternating electrical signal intensity applied to the electrode unit 33 of the electrode sheet 13 is reduced, wherein the second preset temperature is greater than the first preset temperature but less than the preset temperature threshold.

[0122] In step 2424, the electric field intensity reduction is the same for each column group whose alternating electrical signal intensity is reduced.

[0123] For example, when the temperature detection signal is much lower than the preset temperature threshold, the alternating electrical signal is continued to be applied to each electrode unit 33 of the electrode sheet 13 by increasing the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13, or by keeping the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13 constant. When the temperature detection signal is close to the preset temperature threshold, the alternating electrical signal is continued to be applied to each electrode unit 33 of the electrode sheet 13 by keeping the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13 constant, or by decreasing the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13.

[0124] In some other embodiments, controlling the alternating electrical signal strength based on the comparison result in step 242 specifically includes:

[0125] Step 2425: If the temperature at at least one electrode unit 33 exceeds a preset temperature threshold, determine the number of overheating groups.

[0126] Step 2426: If the number of overheating groups exceeds a preset number threshold, stop applying alternating electrical signals to all electrode units 33 of the electrode sheet 13.

[0127] Step 2427: If the number of overheating groups does not exceed the preset number threshold, stop applying alternating electrical signals to all electrode units 33 in the column group where the electrode unit 33 exceeding the preset temperature threshold is located in the electrode sheet 13.

[0128] Further, if the application of alternating electrical signals to all electrode units 33 in the column group where the electrode unit 33 exceeding the preset temperature threshold is located is stopped, the application of alternating electrical signals to electrode units 33 in other columns of the electrode sheet 13 continues. The intensity of the alternating electrical signal applied to the electrode units 33 in other columns of the electrode sheet 13 is adjustable. (Instruction manual)Page 21 / 46 24 CN 121371479 A

[0129] Step 2428: If the number of overheated groups does not exceed a preset threshold, and if the temperature at each electrode unit 33 in the non-overheated groups does not exceed a first preset temperature, then the alternating electrical signal intensity applied to the electrode unit 33 in the non-overheated groups is increased, wherein the first preset temperature is less than a preset temperature threshold.

[0130] In step 2428, the electric field intensity increases by the same amount for each group whose alternating electrical signal intensity is increased.

[0131] Step 2429: If the number of overheated groups does not exceed a preset threshold, and if at least one electrode unit 33 in the non-overheated groups has a temperature exceeding the first preset temperature but less than a preset temperature threshold, then the alternating electrical signal intensity currently applied to the electrode unit 33 in the non-overheated groups remains unchanged.

[0132] Step 2430: If the number of overheated groups does not exceed a preset threshold, and if at least one electrode unit 33 in the non-overheated groups has a temperature exceeding a second preset temperature but less than a preset temperature threshold, then the intensity of the alternating electrical signal applied to the electrode unit 33 in the non-overheated groups is reduced, wherein the second preset temperature is greater than the first preset temperature but less than the preset temperature threshold.

[0133] In step 2430, the electric field intensity reduction is the same for each group whose alternating electrical signal intensity is reduced.

[0134] For example, when the temperature detection signal is much lower than the preset temperature threshold, the alternating electrical signal is continued to be applied to each electrode unit 33 of the electrode sheet 13 by increasing the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13, or the alternating electrical signal is continued to be applied to each electrode unit 33 of the electrode sheet 13 by keeping the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13 unchanged. When the temperature detection signal approaches a preset temperature threshold, the alternating electrical signal is continued to be applied to each electrode unit 33 of the electrode sheet 13 in a manner that keeps the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13 constant, or the alternating electrical signal is continued to be applied to each electrode unit 33 of the electrode sheet 13 in a manner that reduces the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13.

[0135] Referring to FIG11, this application also provides an electrode sheet type identification method, which includes the following steps:

[0136] Step 210: Control the switching unit so that the dual-purpose signal line 19 corresponding to at least one column group in the corresponding electrode sheet 13 is connected to the corresponding temperature sampling point.

[0137] Step 220: Control the control switch 54 corresponding to each row group so that the analog temperature signal of the corresponding electrode unit 33 is sampled based on the corresponding temperature sampling point to determine the temperature detection signal of each electrode unit 33 in each electrode sheet 13.

[0138] Step 250: Identify the type of electrode sheet 13 based on the temperature detection signal.

[0139] Specifically, if the electrode sheet 13 is qualified or the temperature detection units 35 of the electrode sheet 13 are not abnormal or have not malfunctioned, the type of the electrode sheet 13 is identified based on the temperature detection signal detected by the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13.

[0140] This application also provides a signal control method for tumor electric field therapy, used in the above-mentioned tumor electric field therapy system 100 or for the above-mentioned electrode sheet 13. The method includes: combining control of a control switch 54 and a bidirectional switching switch 55 electrically connected to the electrode sheet 13 to switch each electrode unit 33 of the electrode sheet 13 between applying an alternating electrical signal and acquiring a temperature detection signal.

[0141] Referring to FIG12, this application also provides a signal control method for tumor electric field therapy, used for the above-mentioned electrode sheet 13. The method includes:

[0142] Step 310: Combining the control switch 54 and the bidirectional switching switch 55 electrically connected to the corresponding electrode sheet 13 to apply alternating electrical signals to each electrode unit 33 of the electrode sheet 13 and executing step 320;

[0143] Step 320: Combining the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode sheet 13 to collect temperature detection signals of each electrode unit 33 of the electrode sheet 13 in a row and executing step 330;

[0144] Step 330: Determining the combination control mode of the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode sheet 13 according to the collected temperature detection signals and executing step 340;

[0145] Step 340: Control the working state of each electrode unit 33 of the electrode sheet 13 according to the determined combination control method of control switch 54 and bidirectional switching switch 55.

[0146] The working state of each electrode unit 33 of the electrode sheet 13 in step 340 includes at least one of the following: stopping the application of alternating current signal and continuing to collect temperature detection signal, and stopping the collection of temperature detection signal and continuing to apply alternating current signal. Continuing to apply alternating current signal includes continuing to apply alternating current signal by increasing the voltage or current amplitude of the currently applied alternating current signal, or continuing to apply alternating current signal by keeping the voltage or current amplitude of the currently applied alternating current signal unchanged, or continuing to apply alternating current signal by decreasing the voltage or current amplitude of the currently applied alternating current signal.

[0147] The working state of each electrode unit 33 of the electrode sheet 13 is determined by the temperature detection signal it collects. Each electrode unit 33 of the electrode sheet 13 is divided into different regions. By combining the control switch 54 and the bidirectional switching switch 55, each electrode unit 33 in each region can be cyclically switched between applying an alternating electrical signal and acquiring a temperature detection signal.

[0148] This application embodiment provides another method for detecting the temperature of an electrode sheet in a tumor electric field therapy system 100. Referring to Figure 13, the temperature detection method includes:

[0149] Step 510: Disconnect the input of the alternating electrical signal to the electrode sheet 13, perform combined control of multiple control switches 54 and multiple bidirectional switching switches 55, and acquire the temperature detection signal of the temperature detection unit 35 of the electrode sheet 13 corresponding to each combination;

[0150] Step 520: Sample and convert the temperature detection signal detected by each temperature detection unit 35 in the electrode sheet 13 to obtain a digital temperature signal;

[0151] Step 530: Transmit the digital temperature signal to the electric field generator 30 of the tumor electric field therapy system 100 so that the electric field generator 30 can determine the temperature at the corresponding electrode unit 33 according to the digital temperature signal.

[0152] In step 510, the combined control of multiple control switches 54 and multiple bidirectional switching switches 55 specifically includes:

[0153] Step 511: Place all bidirectional switching switches 55 at the signal acquisition terminal 1 to conduct the electrical connection between the signal terminals 35-2 of each temperature detection unit 35 corresponding to each electrode unit 33 and the corresponding ADC unit 52;

[0154] Step 512: Sequentially close one of the multiple control switches 54 individually to collect the temperature detection signals detected by each temperature detection unit 35 corresponding to each electrode unit 33 in the corresponding row group.

[0155] In step 512, sequentially closing one of the multiple control switches 54 individually can conduct the detection channel that is electrically connected to each temperature detection unit 35 in the row group corresponding to the closed control switch 54.

[0156] Thus, the temperature detection signals of each temperature detection unit 35 in each row group can be obtained sequentially, and then processed by the adapter 20 or the electric field generator 30 to obtain the temperature corresponding to all electrode units 33 on the electrode sheet 13, thereby making the temperature detection of the patient's body surface more comprehensive and accurate.

[0157] For the tumor electric field therapy system 100 of this application embodiment, temperature detection can also be performed on a single electrode unit 33 as needed. The specific process of temperature detection for a certain electrode unit 33 of the electrode sheet 13 is as follows: disconnect the input of the alternating current signal, place the bidirectional switching switch 55 corresponding to the column group where the electrode unit 33 that needs to be measured individually is located at the signal acquisition terminal 1, and place the remaining bidirectional switching switches 55 at the signal input terminal 2; at the same time, turn on and ground the control switch 54 corresponding to the row group where the electrode unit 33 that needs to be measured individually is located, and turn off all the remaining control switches 54. Therefore, the temperature detection signal of the temperature detection unit 35 corresponding to the electrode unit 33 that requires separate temperature measurement can be sampled to obtain the temperature.Temperature of electrode unit 33. For example, if electrode unit 33 that needs to be measured individually is electrode unit 33-1, then the bidirectional switch 55-1 corresponding to electrode unit 33-1 is set to signal acquisition terminal 1, and the remaining bidirectional switches (55-2 to 55-5) are all set to signal input terminal 2; at the same time, the control switch 18-1 corresponding to electrode unit 33-1 is closed and grounded, and the remaining control switches (18-2 to 18-4) are all opened. Thus, the temperature of electrode unit 33-1 can be detected.

[0158] This application embodiment also provides another method for applying alternating electrical signals for tumor electric field therapy, applied to the tumor electric field therapy system 100 described above. Referring to FIG14, the alternating electrical signal application method includes:

[0159] Step 610: Determine the region (1-5) in the electrode sheet 13 where the electrode unit 33 to which the alternating electrical signal needs to be applied is located;

[0160] Step 611: Combine and control multiple control switches 54 and multiple bidirectional switching switches 55 electrically connected to the electrode sheet 13 to apply the alternating electrical signal.

[0161] Step 611 involves combining multiple control switches 54 and multiple bidirectional switching switches 55 electrically connected to the electrode plate 13, specifically as follows:

[0162] Step 612: Disconnect all control switches 54 electrically connected to the electrode plate 13;

[0163] Step 613: Determine the column groups of the electrode units 33 in the areas where alternating electrical signals need to be applied;

[0164] Step 614: Determine the bidirectional switching switches 55 electrically connected to the electrode units 33 in the column groups based on the determined column groups of the electrode units 33 in the column groups;

[0165] Step 615: Control the bidirectional switching switches 55 electrically connected to the electrode units 33 in the areas where alternating electrical signals need to be applied, so that the electrode units 33 in the areas where alternating electrical signals need to be applied are electrically connected to the alternating power line 57 to apply alternating electrical signals; simultaneously control the remaining bidirectional switching switches 55 so that each electrode unit 33 in the areas where alternating electrical signals do not need to be applied is connected to the alternating power line 57. The electrical connection between them is disconnected and the application of alternating electrical signals is stopped.

[0166] In step 615, "the electrode unit that needs to be applied with alternating electrical signals is electrically connected to the alternating power line 57 to apply alternating electrical signals and the electrode unit 33 in the area where alternating electrical signals do not need to be applied is disconnected from the alternating power line 57 to stop the application of alternating electrical signals" is achieved by placing the bidirectional switching switch 55 electrically connected to the electrode unit 33 in the column group corresponding to the area (1-5) in the electrode sheet 13 where alternating electrical signals are to be applied in its signal input terminal 2, and placing all the bidirectional switching switches 55 electrically connected to the electrode unit 33 in the remaining column groups in the signal acquisition terminal 1.

[0167] The first controller 51 or electric field generator in the adapter 20 of the tumor electric field therapy system 100 of this application embodimentThe device 30 is equipped with a preset quantity threshold, a first preset temperature t1, a second preset temperature t2, and a preset temperature threshold t0, wherein the first preset temperature t1 is lower than the second preset temperature t2, and the second preset temperature t2 is lower than the preset temperature threshold t0.

[0168] This application embodiment also provides an alternating electrical signal application method based on temperature detection signal, used in the above-mentioned tumor electric field therapy system 100. Please refer to FIG15. The application method includes:

[0169] Step 710: Start the tumor electric field therapy system 100;

[0170] Step 711: Combine the control switch 54 (also called grounding switch) and the bidirectional switching switch 55 electrically connected to the corresponding electrode sheet 13 to apply an alternating electrical signal to each electrode unit 33 of the electrode sheet 13;

[0171] Step 712: Combine the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode sheet 13 to obtain the temperature of each electrode unit 33 of the electrode sheet 13;

[0172] Step 713: Determine whether there is an electrode unit 33 with a temperature exceeding a first preset temperature t1. When there is no electrode unit 33 with a temperature exceeding the first preset temperature t1, execute step 714. When there is an electrode unit 33 with a temperature exceeding the first preset temperature t1, execute step 714. When unit 33 is 121371479 A, ​​step 715 is executed;

[0173] Step 714: Continue to apply alternating electrical signals to each electrode unit 33 of electrode sheet 13 by increasing the voltage or current amplitude of the currently applied alternating electrical signal and return to step 712;

[0174] Step 715: Determine whether there is an electrode unit 33 with a temperature exceeding the second preset temperature t2; if there is no electrode unit 33 with a temperature exceeding the second preset temperature t2, execute step 716; if there is an electrode unit 33 with a temperature exceeding the second preset temperature t2, execute step 717;

[0175] Step 716: Continue to apply alternating electrical signals to each electrode unit 33 of electrode sheet 13 by keeping the voltage or current amplitude of the currently applied alternating electrical signal unchanged and return to step 712;

[0176] Step 717: Determine whether there is an electrode unit 33 whose temperature exceeds the preset temperature threshold t0. If there is no electrode unit 33 whose temperature exceeds the preset temperature threshold t0, proceed to step 718; if there is an electrode unit whose temperature exceeds the preset temperature threshold t0, proceed to step 719;

[0177] Step 718: Continue to apply alternating current signals to all electrode units 33 of the electrode sheet 13 by reducing the voltage or current amplitude of the currently applied alternating current signal and return to step 712;

[0178] Step 719: Determine the number of overheated areas and proceed to step 720, wherein the overheated area is the area containing electrode units whose temperature exceeds the preset temperature threshold t0, and the non-overheated area is the area where the temperature of all electrode units within it does not exceed the preset temperature threshold t0;

[0179] Step 720: Determine whether the number of overheated areas exceeds a preset threshold. If the number of overheated areas exceeds the preset threshold, proceed to step 721. If the number of overheated areas does not exceed the preset threshold, proceed to step 724.

[0180] Step 721: Stop applying alternating electrical signals to each electrode unit 33 of the electrode sheet 13 and proceed to step 722.

[0181] Step 722: Combine the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode sheet 13 to obtain the temperature of each electrode unit 33 of the electrode sheet 13 and proceed to step 723.

[0182] Step 723: Determine whether there is an electrode unit 33 with a temperature exceeding the first preset temperature t1. If there is no electrode unit 33 with a temperature exceeding the first preset temperature t1 in the electrode sheet 13, return to step 711. If there is an electrode unit 33 with a temperature exceeding the first preset temperature t1 in the electrode sheet 13, return to step 722.

[0183] Step 724: Distinguish between overheated and non-overheated regions based on whether there are electrode units 33 with temperatures exceeding a preset temperature threshold t0. If the region is an overheated region, proceed to step 725; if the region is a non-overheated region, proceed to step 726.

[0184] Step 725: Stop applying alternating electrical signals to each electrode unit 33 in the overheated region and proceed to step 731.

[0185] Step 726: Determine whether the temperatures of each electrode unit 33 in the non-overheated region do not exceed the first preset temperature t1. If the temperatures of each electrode unit 33 in the non-overheated region do not exceed the first preset temperature t1, proceed to step 727; if any of the electrode units 33 in the non-overheated region have a temperature exceeding the first preset temperature t1, proceed to step 728.

[0186] Step 727: Continue applying alternating electrical signals to each electrode unit 33 in the non-overheated region of the electrode sheet 13 by increasing the voltage or current amplitude of the currently applied alternating electrical signal and proceed to step 731.

[0187] Step 728: Determine whether the temperature of each electrode unit 33 in the non-overheated area does not exceed the second preset temperature t2. If the temperature of each electrode unit 33 in the non-overheated area does not exceed the second preset temperature t2, proceed to step 729. If any of the electrode units 33 in the non-overheated area exceeds the second preset temperature t2, proceed to step 730.

[0188] Step 729: Continue to apply alternating electrical signals to each electrode unit 33 in the non-overheated area of ​​the electrode sheet 13 while maintaining the voltage or current amplitude of the currently applied alternating electrical signal unchanged, and proceed to step 731.

[0189] Step 730: Continue to apply alternating electrical signals to each electrode unit 33 in the non-overheated area of ​​the electrode sheet 13 while reducing the voltage or current amplitude of the currently applied alternating electrical signal, and proceed to step 731. Specification 25 / 46 pages 28 CN 121371479 A

[0190] Step 731: Combine the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode plate 13 to reacquire the temperature of each electrode unit 33 of the electrode plate 13 and select to execute step 732 or step 734. The temperature of each electrode unit 33 of the electrode plate 13 includes the temperature of each electrode unit 33 in the over-temperature region and the temperature of each electrode unit 33 in the non-over-temperature region;

[0191] Step 732: Determine whether the temperature of each electrode unit 33 in the over-temperature region does not exceed the first preset temperature t1. If the temperature of each electrode unit 33 in the over-temperature region does not exceed the first preset temperature t1, execute step 733. If there is a temperature in each electrode unit 33 in the over-temperature region that exceeds the first preset temperature t1, return to step 731;

[0192] Step 733: Redetermine the region as a non-over-temperature region and execute step 734;

[0193] Step 734: Determine whether the temperature of each electrode unit 33 in the obtained non-overheated area does not exceed the first preset temperature t1. If the temperature of each electrode unit 33 in the non-overheated area does not exceed the first preset temperature t1, proceed to step 735. If any of the electrode units 33 in the non-overheated area exceeds the first preset temperature t1, proceed to step 736.

[0194] Step 735: Continue to apply alternating current signals to each electrode unit 33 in the non-overheated area by increasing the voltage or current amplitude of the currently applied alternating current signal and return to step 712.

[0195] Step 736: Determine whether the temperature of each electrode unit 33 in the obtained non-overheated area does not exceed the second preset temperature t2. If the temperature of each electrode unit 33 in the non-overheated area does not exceed the second preset temperature t2, proceed to step 737. If any of the electrode units 33 in the non-overheated area exceeds the second preset temperature t2, proceed to step 738.

[0196] Step 737: Continue applying alternating electrical signals to each electrode unit 33 in the non-overheated area while keeping the voltage or current amplitude of the currently applied alternating electrical signal constant, and return to step 712;

[0197] Step 738: Determine whether the temperature of each electrode unit 33 in the non-overheated area does not exceed the preset temperature threshold t0. If the temperature of each electrode unit 33 in the non-overheated area does not exceed the preset temperature threshold t0, execute step 739. If there is a temperature in each electrode unit 33 in the non-overheated area that exceeds the preset temperature threshold t0, return to step 719;

[0198] Step 739: Continue applying alternating electrical signals to each electrode unit 33 in the non-overheated area while reducing the voltage or current amplitude of the currently applied alternating electrical signal, and return to step 712.

[0199] Specifically, the process of applying alternating electrical signals to each electrode unit 33 of the electrode sheet by the combined control and the control switch 54 and the bidirectional switching switch 55 electrically connected to the corresponding electrode sheet 13 in step 711 is as follows:

[0200] Disconnect all control switches 54 electrically connected to the corresponding electrode piece 13, and simultaneously switch all bidirectional switching switches 55 electrically connected to the corresponding electrode piece 13 to the end that applies an alternating electrical signal to each electrode unit 33; or

[0201] Disconnect all control switches 54 electrically connected to the corresponding electrode piece 13, and simultaneously switch all bidirectional switching switches 55 electrically connected to the corresponding electrode piece 13 to the end that connects each electrode unit 33 to the alternating power line 57; or

[0202] Disconnect all control switches 54 electrically connected to the corresponding electrode piece 13, and simultaneously switch all bidirectional switching switches 55 electrically connected to the corresponding electrode piece 13 to their respective signal input terminals 2.

[0203] The process of obtaining the temperature of each electrode unit 33 of the electrode plate 13 in steps 712, 722, and 731 is specifically as follows:

[0204] Control the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch all of its end that applies alternating electrical signals to each electrode unit 33 to its end that collects temperature data from each electrode unit 33, and sequentially close the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode plate 13 to obtain the temperature of each electrode unit 33 of the electrode plate 13; or

[0205] Control the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch all of its signal input terminal 2 that applies alternating electrical signals to each electrode unit 33 to its signal acquisition terminal 1, and sequentially close the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode plate 13 to obtain the temperature of each electrode unit 33; or

[0205] Control the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch all of its signal input terminal 2 that applies alternating electrical signals to each electrode unit 33 to its signal acquisition terminal 1, and sequentially close the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode plate 13. The control switch 54, electrically connected to the temperature detection unit 35 corresponding to the electrode 13, is used to obtain the temperature of each electrode unit 33 of the electrode plate 13; or

[0206] the bidirectional switching switch 55 electrically connected to the electrode plate 13 is controlled to switch the electrode plate 13 from being electrically connected to the alternating power line 57 to being electrically connected to the temperature detection unit 35 corresponding to each electrode unit 33 and the corresponding analog-to-digital converter 53, and the control switch 54 electrically connected to the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode plate 13 is closed in sequence at different times to obtain the temperature of each electrode unit 33 of the electrode plate 13; or

[0207] the bidirectional switching switch 55 electrically connected to the electrode plate 13 is controlled to switch the electrode plate 13 from transmitting alternating electrical signals to transmitting direct current signals or temperature detection signals, and the control switch 54 electrically connected to the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode plate 13 is closed in sequence at different times to obtain the temperature of each electrode unit 33 of the electrode plate 13.

[0208] The first preset temperature in steps 713, 723, 726, 732, and 734 is 40℃-40.3℃, preferably 40.2℃. The second preset temperature in steps 715, 728, and 736 is 40.4℃ to 40.6℃, preferably...40.5℃; the preset temperature threshold in steps 717 and 738 is 41℃ to 41.5℃, preferably 41℃; the preset quantity threshold in step 720 is preferably 2.

[0209] The process of continuing to apply alternating electrical signals in steps 714, 716, 718, 727, 729, 730, 735, 737, and 739 is specifically as follows:

[0210] Disconnect the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which alternating electrical signals need to be applied, and simultaneously control the bidirectional switching switch 55 electrically connected to the electrode unit 33 to which alternating electrical signals need to be applied to conduct the alternating electrical signal transmission path electrically connected to the electrode unit 33 to which alternating electrical signals need to be applied to continue applying alternating electrical signals to the electrode unit 33 to which alternating electrical signals need to be applied; or

[0211] The control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied is disconnected, and at the same time, the bidirectional switching switches 55 electrically connected to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied are switched from their respective signal acquisition terminals 1 to their respective signal input terminals 2, so as to continue applying the alternating electrical signal to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied; or

[0212] The control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied is disconnected, and at the same time, the signal input terminals 2 of the bidirectional switching switches 55 electrically connected to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied are electrically connected to the alternating power supply line 57, so as to continue applying the alternating electrical signal to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied; or

[0213] Disconnect the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 that needs to continue applying alternating current signal, and simultaneously control the bidirectional switching switch 55 electrically connected to the electrode unit 33 that needs to continue applying alternating current signal so that its respective signal input terminal 2 is closed and signal acquisition terminal 1 is disconnected, thereby continuing to apply alternating current signal to the electrode unit 33 that needs to continue applying alternating current signal; or

[0214] Disconnect the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 that needs to continue applying alternating current signal, and simultaneously control the bidirectional switching switch 55 electrically connected to the electrode unit 33 that needs to continue applying alternating current signal so that the electrode unit 33 that needs to continue applying alternating current signal switches from transmitting temperature detection signal to applying alternating current signal.

[0215] The increase in the voltage or current amplitude of the currently applied alternating current signal in steps 714, 727, and 735 specifically involves boosting the voltage of the currently applied alternating current signal by a DC voltage amplitude increment of 0.03V per second.

[0216] The steps 718, 730, and 739 described above are for reducing the voltage or current of the currently applied alternating electrical signal.The alternating current signal is applied in a manner that is 5V smaller than the voltage amplitude of the currently applied alternating current signal and is applied for 3 minutes. Instruction manual, pages 27 / 46, 30 CN 121371479 A

[0217] The process of stopping the application of alternating electrical signals to each electrode unit 33 of the electrode plate 13 as described in step 721 is specifically as follows:

[0218] Controlling the bidirectional switching switch 55 electrically connected to the electrode plate 13 to disconnect the electrical connection between each electrode unit 33 of the electrode plate 13 and the alternating power supply line 57; or

[0219] Controlling the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch all of its end that applies alternating electrical signals to each electrode unit 33 to its end that performs temperature acquisition on each electrode unit 33; or

[0220] Controlling the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch all of its signal input terminal 2 that applies alternating electrical signals to each electrode unit 33 to its signal acquisition terminal 1; or

[0221] Control the bidirectional switching switch 55 electrically connected to the electrode 13 to switch the electrode 13 from being electrically connected to the alternating power line 57 for each electrode unit 33 to being electrically connected to the temperature detection unit 35 corresponding to each electrode unit 33 and the corresponding analog-to-digital converter 53; or

[0222] control the bidirectional switching switch 55 electrically connected to the electrode 13 to switch the electrode unit 33 of the electrode 13 from transmitting alternating electrical signals to transmitting DC electrical signals or temperature detection signals for the corresponding temperature detection unit 35.

[0223] The process of stopping the application of alternating electrical signals to each electrode unit 33 in the over-temperature region as described in step 725 specifically includes:

[0224] Controlling the bidirectional switching switch 55 electrically connected to each electrode unit 33 in the over-temperature region to disconnect the electrical connection between each electrode unit 33 in the over-temperature region and the alternating power line 57; or

[0225] Controlling the bidirectional switching switch 55 electrically connected to each electrode unit 33 in the over-temperature region to switch all of its ends that apply alternating electrical signals to each electrode unit 33 in the over-temperature region to the ends that perform temperature acquisition by each electrode unit 33 in the over-temperature region; or

[0226] Controlling the bidirectional switching switch 55 electrically connected to each electrode unit 33 in the over-temperature region to switch all of its signal input terminals 2 that apply alternating electrical signals to each electrode unit 33 in the over-temperature region to its signal acquisition terminals 1; or

[0227] The bidirectional switching switch 55, which controls the electrical connection between each electrode unit 33 in the over-temperature zone, switches each electrode unit 33 in the over-temperature zone from being electrically connected to the alternating power line 57 to being electrically connected to its corresponding temperature detection unit 35 and its corresponding analog-to-digital converter 53; or

[0228] the bidirectional switching switch 55, which controls the electrical connection between each electrode unit 33 in the over-temperature zone, switches each electrode unit 33 in the over-temperature zone from transmitting alternating electrical signals to transmitting direct current signals or temperature detection signals through its corresponding temperature detection unit 35.

[0229] In the above control method, the tumor electric field therapy system 100 includes at least two pairs of electrode plates 13 to alternately apply alternating electric fields with different directions. Each electrode plate 13 can alternately switch between applying an alternating electric signal and transmitting a temperature detection signal.

[0230] The first controller 51 or electric field generator 30 in the adapter 20 of the tumor electric field therapy system 100 of this application embodiment is further provided with a third preset temperature t3. The third preset temperature t3 is higher than the second preset temperature t2 but still lower than the preset temperature threshold t0. The third preset temperature t3 is closer to the preset temperature threshold t0 than the second preset temperature t2. This application embodiment also provides an alternating electrical signal control method based on temperature detection signals for the above-mentioned tumor electric field therapy system. Referring to Figure 16, the alternating electrical signal control method includes:

[0231] Step 810: Activating the tumor electric field therapy system 100;

[0232] Step 811: Combining the control switch 54 (also called a grounding switch) and the bidirectional switching switch 55 electrically connected to the corresponding electrode sheet 13 to apply an alternating electrical signal to each electrode unit 33 of the electrode sheet 13;

[0233] Step 812: Combining the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode sheet 13 to obtain the temperature of each electrode unit 33 of the electrode sheet 13;

[0234] Step 813: Determine if there is an electrode unit 33 with a temperature exceeding the first preset temperature t1. If there is no electrode unit 33 with a temperature exceeding the first preset temperature t1, proceed to step 814. If there is an electrode unit 33 with a temperature exceeding the first preset temperature t1, proceed to step 815.

[0235] Step 814: Continue to apply alternating electrical signals to each electrode unit 33 of the electrode sheet 13 by increasing the voltage or current amplitude of the currently applied alternating electrical signal and return to step 812.

[0236] Step 815: Determine if there is an electrode unit 33 with a temperature exceeding the second preset temperature t2. If there is no electrode unit 33 with a temperature exceeding the second preset temperature t2, proceed to step 816. If there is an electrode unit 33 with a temperature exceeding the second preset temperature t2, proceed to step 817.

[0237] Step 816: Continue to apply alternating electrical signals to each electrode unit 33 of the electrode sheet 13 by keeping the voltage or current amplitude of the currently applied alternating electrical signal unchanged and return to step 812.

[0238] Step 817: Determine whether there is an electrode unit 33 with a temperature exceeding the third preset temperature t3. If there is no electrode unit 33 with a temperature exceeding the third preset temperature t3, proceed to step 818; if there is an electrode unit with a temperature exceeding the third preset temperature t3, proceed to step 819;

[0239] Step 818: Continue to apply the alternating current signal to the electrode sheet by reducing the voltage or current amplitude of the currently applied alternating current signal.13. Apply alternating electrical signals to all electrode units 33 and return to step 812;

[0240] Step 819: Determine whether there are electrode units 33 with temperatures exceeding the preset temperature threshold t0. If there are no electrode units 33 with temperatures exceeding the preset temperature threshold t0, proceed to step 820; if there are electrode units with temperatures exceeding the preset temperature threshold t0, proceed to step 821;

[0241] Step 820: Continue to apply alternating electrical signals to all electrode units 33 of electrode sheet 13 by reducing the voltage or current amplitude of the currently applied alternating electrical signal and return to step 812;

[0242] Step 821: Determine the number of overheated areas and proceed to step 822, wherein the overheated area is the area containing electrode units with temperatures exceeding the preset temperature threshold t0, and the non-overheated area is the area where the temperature of all electrode units within it does not exceed the preset temperature threshold t0;

[0243] Step 822: Determine whether the number of overheated areas exceeds a preset threshold. If the number of overheated areas exceeds the preset threshold, proceed to step 823. If the number of overheated areas does not exceed the preset threshold, proceed to step 826.

[0244] Step 823: Stop applying alternating electrical signals to each electrode unit 33 of the electrode sheet 13 and proceed to step 824.

[0245] Step 824: Combine the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode sheet 13 to obtain the temperature of each electrode unit 33 of the electrode sheet 13 and proceed to step 825.

[0246] Step 825: Determine whether there is an electrode unit 33 with a temperature exceeding the first preset temperature t1. If there is no electrode unit 33 with a temperature exceeding the first preset temperature t1 in the electrode sheet 13, return to step 811. If there is an electrode unit 33 with a temperature exceeding the first preset temperature t1 in the electrode sheet 13, return to step 824.

[0247] Step 826: Distinguish between overheated and non-overheated regions based on whether there are electrode units 33 with temperatures exceeding the preset temperature threshold t0. If the region is an overheated region, proceed to step 827; if the region is a non-overheated region, proceed to step 828.

[0248] Step 827: Stop applying alternating electrical signals to each electrode unit 33 in the overheated region and proceed to step 835.

[0249] Step 828: Determine whether the temperatures of each electrode unit 33 in the non-overheated region do not exceed the first preset temperature t1. If the temperatures of each electrode unit 33 in the non-overheated region do not exceed the first preset temperature t1, proceed to step 829; if there is a temperature in each electrode unit 33 in the non-overheated region that exceeds the first preset temperature t1, proceed to step 830.

[0250] Step 829: Continue applying alternating electrical signals to the electrode sheet by increasing the voltage or current amplitude of the currently applied alternating electrical signal. (Page 29 / 46, CN 121371479 A) 13. An alternating electrical signal is applied to each electrode unit 33 in the non-over-temperature zone, and step 835 is executed;

[0251] Step 830: Determine whether the temperature of each electrode unit 33 in the non-overheated area does not exceed the second preset temperature t2. If the temperature of each electrode unit 33 in the non-overheated area does not exceed the second preset temperature t2, execute step 831. If any of the electrode units 33 in the non-overheated area has a temperature exceeding the second preset temperature t2, execute step 832.

[0252] Step 831: Continue to apply alternating electrical signals to each electrode unit 33 in the non-overheated area of ​​the electrode sheet 13 while maintaining the voltage or current amplitude of the currently applied alternating electrical signal unchanged, and execute step 835.

[0253] Step 832: Determine whether any electrode unit 33 in the non-overheated area has a temperature exceeding the third preset temperature t3. If the temperature of each electrode unit 33 in the non-overheated area does not exceed the third preset temperature t3, execute step 833. If any of the electrode units 33 in the non-overheated area has a temperature exceeding the third preset temperature t3, execute step 834.

[0254] Step 833: Continue applying alternating current signals to each electrode unit 33 in the non-overheated region of electrode sheet 13 in a manner that reduces the voltage or current amplitude of the currently applied alternating current signal and execute step 835;

[0255] Step 834: Continue applying alternating current signals to each electrode unit 33 in the non-overheated region of electrode sheet 13 in a manner that further reduces the voltage or current amplitude of the currently applied alternating current signal and execute step 835;

[0256] Step 835: Combine the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode sheet 13 to reacquire the temperature of each electrode unit 33 of the electrode sheet 13 and select to execute step 836 or step 838. The temperature of each electrode unit 33 of the electrode sheet 13 includes the temperature of each electrode unit 33 in the overheated region and the temperature of each electrode unit 33 in the non-overheated region;

[0257] Step 836: Determine whether the temperature of each electrode unit 33 in the overheated area does not exceed the first preset temperature t1. If the temperature of each electrode unit 33 in the overheated area does not exceed the first preset temperature t1, proceed to step 837. If any of the electrode units 33 in the overheated area exceeds the first preset temperature t1, return to step 835.

[0258] Step 837: Redetermine the area as an overheated area and proceed to step 838.

[0259] Step 838: Determine whether the temperature of each electrode unit 33 in the obtained overheated area does not exceed the first preset temperature t1. If the temperature of each electrode unit 33 in the overheated area does not exceed the first preset temperature t1, proceed to step 839. If any of the electrode units 33 in the overheated area exceeds the first preset temperature t1, proceed to step 840.

[0260] Step 839: Continue to move towards the overheated area by increasing the voltage or current amplitude of the currently applied alternating electrical signal.Step 840: Determine whether the temperature of each electrode unit 33 in the temperature-controlled area does not exceed the second preset temperature t2. If the temperature of each electrode unit 33 in the temperature-controlled area does not exceed the second preset temperature t2, execute step 841. If the temperature of any electrode unit 33 in the temperature-controlled area exceeds the second preset temperature t2, execute step 842. Step 841: Continue to apply alternating electrical signals to each electrode unit 33 in the temperature-controlled area while keeping the voltage or current amplitude of the currently applied alternating electrical signal unchanged, and return to step 812. Step 842: Determine whether the temperature of each electrode unit 33 in the temperature-controlled area does not exceed the third preset temperature t3. If the temperature of each electrode unit 33 in the temperature-controlled area does not exceed the third preset temperature t3, execute step 843. When the temperature of any electrode unit 33 in the non-overheated area exceeds the third preset temperature t3, step 844 is executed;

[0264] Step 843: Continue to apply alternating current signals to each electrode unit 33 in the non-overheated area by reducing the voltage or current amplitude of the currently applied alternating current signal and return to step 812;

[0265] Step 844: Determine whether the temperature of each electrode unit 33 in the non-overheated area does not exceed the preset temperature threshold t0. When the temperature of each electrode unit 33 in the non-overheated area does not exceed the preset temperature threshold t0, step 845 is executed. When the temperature of any electrode unit 33 in the non-overheated area exceeds the preset temperature threshold t0, return to step 821;

[0266] Step 845: Continue to apply alternating electrical signals to each electrode unit 33 of the non-overheated region in a manner that further reduces the voltage or current amplitude of the currently applied alternating electrical signal and return to step 812.

[0267] Specifically, the process of combining the control switches 54 and bidirectional switching switches 55 electrically connected to the corresponding electrode plates 13 in step 811 to apply alternating electrical signals to each electrode unit 33 of the electrode plate is as follows:

[0268] Disconnect all control switches 54 electrically connected to the corresponding electrode plates 13, and simultaneously switch all bidirectional switching switches 55 electrically connected to the corresponding electrode plates 13 to the end that applies alternating electrical signals to each electrode unit 33; or

[0269] Disconnect all control switches 54 electrically connected to the corresponding electrode plates 13, and simultaneously switch all bidirectional switching switches 55 electrically connected to the corresponding electrode plates 13 to the end that applies alternating electrical signals to each electrode unit 33; or

[0270] Disconnect all control switches 54 electrically connected to the corresponding electrode plates 13, and simultaneously switch all bidirectional switching switches 55 electrically connected to the corresponding electrode plates 13 to the end that applies alternating electrical signals to each electrode unit 33.All the connected bidirectional switching switches 55 are switched to their respective signal input terminals 2.

[0271] The process of obtaining the temperature of each electrode unit 33 of the electrode plate 13 in steps 812, 824, and 835 is specifically as follows:

[0272] Control the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch all of its ends that apply alternating electrical signals to each electrode unit 33 to its ends that collect temperature data from each electrode unit 33, and sequentially close the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode plate 13 to obtain the temperature of each electrode unit 33 of the electrode plate 13; or

[0273] Control the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch all of its signal input terminals 2 that apply alternating electrical signals to each electrode unit 33 to its signal acquisition terminals 1, and sequentially close the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode plate 13 to obtain the temperature of each electrode unit 33 of the electrode plate 13; or

[0274] The bidirectional switching switch 55 electrically connected to the electrode 13 is controlled to switch the electrode 13 from being electrically connected to the alternating power line 57 for each electrode unit 33 to being electrically connected to the temperature detection unit 35 corresponding to each electrode unit 33 and the corresponding analog-to-digital converter 53, and the control switch 54 electrically connected to the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode 13 is closed in a time-sharing sequence to obtain the temperature of each electrode unit 33 of the electrode 13; or

[0275] The bidirectional switching switch 55 electrically connected to the electrode 13 is controlled to switch the electrode unit 33 of the electrode 13 from transmitting alternating electrical signals to transmitting DC electrical signals or temperature detection signals for the corresponding temperature detection unit 35, and the control switch 54 electrically connected to the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode 13 is closed in a time-sharing sequence to obtain the temperature of each electrode unit 33 of the electrode 13.

[0276] The first preset temperature in steps 813, 825, 828, 836, and 838 is 40℃-40.3℃, preferably 40.2℃. The second preset temperature in steps 815, 830, and 840 is 40.4℃ to 40.6℃, preferably 40.5℃; the third preset temperature in steps 817, 832, and 842 is 40.7℃ to 40.9℃, preferably 40.8℃; the preset temperature threshold in steps 819 and 844 is 41℃ to 41.5℃, preferably 41℃; the preset quantity threshold in step 822 is preferably 2.

[0277] The process of continuing to apply the alternating electrical signal as described in steps 814, 816, 818, 820, 829, 831, 833, 834, 839, 841, 843, and 845 is specifically as follows:

[0278] Disconnect the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied, and simultaneously control the bidirectional switching switch 55 electrically connected to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied to conduct the alternating electrical signal transmission path electrically connected to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied to continue applying the alternating electrical signal to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied; or, as stated on page 34 of the specification 31 / 46, CN 121371479 A

[0279] , disconnect the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied to, and simultaneously control the bidirectional switching switch 55 electrically connected to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied to switch from its respective signal acquisition terminal 1 to its respective signal input terminal 2 to continue applying the alternating electrical signal to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied; or

[0280] The control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied is disconnected, and at the same time, the signal input terminals 2 of the bidirectional switching switches 55 electrically connected to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied are electrically connected to the alternating power supply line 57, so that the alternating electrical signal continues to be applied to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied; or

[0281] The control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied is disconnected, and at the same time, the bidirectional switching switches 55 electrically connected to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied are controlled to close their respective signal input terminals 2 and disconnect their signal acquisition terminals 1, so that the alternating electrical signal continues to be applied to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied; or

[0282] The control switch 54, which is electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 that needs to continue applying the alternating current signal, is disconnected, and at the same time, the bidirectional switching switch 55, which is electrically connected to the electrode unit 33 that needs to continue applying the alternating current signal, is controlled so that the electrode unit 33 that needs to continue applying the alternating current signal switches from transmitting the temperature detection signal to applying the alternating current signal.

[0283] The method of increasing the voltage or current amplitude of the currently applied alternating current signal in steps 814, 829, and 839 specifically refers to boosting the currently applied alternating current signal by increasing the DC voltage amplitude by 0.03V per second before continuing to apply the alternating current signal.

[0284] The method of continuing to apply the alternating current signal by reducing the voltage or current amplitude of the currently applied alternating current signal as described in steps 818, 820, 833, 834, 843, and 845 specifically refers to continuing to apply the alternating current signal by reducing the voltage or current amplitude of the currently applied alternating current signal by 5V for 3 minutes.

[0285] The process of stopping the application of alternating electrical signals to each electrode unit 33 of the electrode plate 13 as described in step 823 is specifically as follows:

[0286] Controlling the bidirectional switching switch 55 electrically connected to the electrode plate 13 to disconnect the electrical connection between each electrode unit 33 of the electrode plate 13 and the alternating power line 57; or

[0287] Controlling the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch all of its ends that apply alternating electrical signals to each electrode unit 33 to its ends that perform temperature acquisition on each electrode unit 33; or

[0288] Controlling the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch all of its signal input terminals 2 that apply alternating electrical signals to each electrode unit 33 to its signal acquisition terminals 1; or

[0289] Controlling the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch the electrode plate 13 from the electrical connection between each electrode unit 33 and the alternating power line 57 to the temperature detection unit 35 and the corresponding analog-to-digital converter 53 corresponding to each electrode unit 33. Electrical connection; or

[0290] Control the bidirectional switching switch 55 electrically connected to the electrode sheet 13 to switch each electrode unit 33 of the electrode sheet 13 from transmitting alternating electrical signals to transmitting direct current signals or temperature detection signals from the corresponding temperature detection unit 35.

[0291] The process of stopping the application of alternating electrical signals to each electrode unit 33 in the over-temperature zone as described in step 827 is specifically as follows:

[0292] Controlling the bidirectional switching switch 55 electrically connected to each electrode unit 33 in the over-temperature zone to disconnect the electrical connection between each electrode unit 33 in the over-temperature zone and the alternating power line 57; or

[0293] Controlling the bidirectional switching switch 55 electrically connected to each electrode unit 33 in the over-temperature zone to switch all the ends from the end that applies alternating electrical signals to each electrode unit 33 in the over-temperature zone to the end that performs temperature acquisition; or

[0294] Controlling the bidirectional switching switch 55 electrically connected to each electrode unit 33 in the over-temperature zone to switch all the signal input terminals 2 that apply alternating electrical signals to each electrode unit 33 in the over-temperature zone to its signal acquisition terminal 1; or

[0295] The bidirectional switching switch 55, which controls the electrical connection between each electrode unit 33 in the overheated area, switches each electrode unit 33 in the overheated area from being electrically connected to the alternating power line 57 to being electrically connected to its corresponding temperature detection unit 35 and its corresponding analog-to-digital converter 53; or

[0296] the bidirectional switching switch 55, which controls the electrical connection between each electrode unit 33 in the overheated area, switches each electrode unit 33 in the overheated area from transmitting alternating electrical signals to transmitting direct current signals or temperature detection signals through its corresponding temperature detection unit 35.

[0297] When the tumor electric field therapy system 100 is in the standby state before starting work, no alternating current signal is applied to the electrode unit 33.The transformer signal, the first controller 51 of the converter 20 or the second controller 37 of the electric field generator 30 controls the bidirectional switching switch 55 (55-1 to 55-5) to switch to the signal acquisition terminal 1, and the control switches 54 (54-1 to 54-4) are turned on in sequence. The ADC unit 52 receives the temperature detection signal of the temperature detection unit 35 corresponding to each row of electrode units 33 (33-1 to 33-20) in sequence.

[0298] When control switch 54-1 is on, control switches (54-2, 54-3, 54-4) are all off, and bidirectional switches (55-1 to 55-5) are all set to signal acquisition terminal 1, ADC unit 52 receives temperature detection signals from temperature detection units 35 corresponding to electrode units (33-1 to 33-5);

[0299] When control switch 54-2 is on, control switches (54-1, 54-3, 54-4) are all off, and bidirectional switches (55-1 to 55-5) are all set to signal acquisition terminal 1, ADC unit 52 receives temperature detection signals from temperature detection units 35 corresponding to electrode units (33-6 to 33-10);

[0300] When control switch 54-3 is on, control switches (54-1, 54-2, 54-4) are all off, and bidirectional switches (55-1 to 55-5) are all placed at signal acquisition terminal 1, ADC unit 52 receives temperature detection signals from temperature detection units 35 corresponding to electrode units (33-11 to 33-15);

[0301] When control switch 54-4 is on, control switches (54-1, 54-2, 54-3) are all off, and bidirectional switches (55-1 to 55-5) are all placed at signal acquisition terminal 1, ADC unit 52 receives temperature detection signals from temperature detection units 35 corresponding to electrode units (33-16 to 33-20).

[0302] The first controller 51 receives the temperature detection signals of the temperature detection units 35 corresponding to each electrode unit 33 (33-1 to 33-20) through the ADC unit 52, and transmits them to the AC signal generator 39 of the electric field generator 30 through the first communication unit 56 and the second communication unit 38. Then, the second controller 37 controls or adjusts the alternating electrical signals applied to each electrode unit 33.

[0303] Although the various operations are depicted in the drawings in a specific order, this should not be construed as requiring these operations to be performed in the specific order shown or in chronological order, nor should it be construed as requiring all the operations shown to be performed to obtain the desired result.

[0304] Example 2:

[0305] The main concept of the tumor electric field therapy system 100 described above is that both the adapter 20 and the electric field generator 30 are provided with an alternating power supply line 57 to control the synchronous change of the alternating electrical signals of all electrode units 33 on an electrode sheet 13, such as voltage orWhile the current may rise or fall simultaneously, it is not possible to apply different alternating electrical signals, such as different voltages or currents, to different groups of electrode units 33 at the same time. Referring to Figures 17 to 20, another tumor electric field therapy system 100' is described below. Its main concept is the same as the tumor electric field therapy system 100 described above, except that: in this tumor electric field therapy system 100', each group of electrode units 33' on the corresponding electrode plates 13' in the adapter 20' and electric field generator 30' is provided with a corresponding alternating power supply line 57', thereby allowing different alternating electrical signals, such as different voltages or currents, to be applied simultaneously to different groups of electrode units 33'.

[0306] Figure 18 is a schematic diagram of the circuit connection of an electrode 13', an adapter 20', and an electric field generator 30' in another tumor electric field therapy system 100' according to an embodiment of this application. The tumor electric field therapy system 100' includes: at least one pair of electrode 13', an adapter 20' connected to the electrode 13', and an electric field generator 30' connected to the adapter 20'.

[0307] The specific structure of the electrode 13' is the same as that of the electrode 13 described above, and will not be repeated here.

[0308] The specific structure of the adapter 20' is similar to that of the adapter 20 described above, except that: referring to Figures 18 and 19, each electrode plate 13' in the adapter 20' is provided with 5 alternating power lines 57', and the 5 alternating power lines 57' are set one-to-one with the 5 column electrode units 33' of one electrode plate 13'. Each electrode plate 13' is provided with a corresponding bidirectional switching switch 55' and a grounding switch 54'. The signal input terminal 2 of the bidirectional switching switch 55' is electrically connected to a separate AC power line 57', so that the tumor electric field therapy system 100' can apply different alternating electrical signals, such as different voltages or currents, to different column electrode units 33' in each electrode plate 13' as needed.

[0309] The specific structure of the electric field generator 30' is similar to that of the electric field generator 30 described above, except that: referring to Figures 18 and 20, each alternating power line 57' between the AC signal generator 39' and the adapter 20' is provided with a power supply switch 40' to individually control the switching on and off of the alternating electrical signal of each column of electrode units 33' for each electrode sheet 13'.

[0310] Specifically, referring to Figures 18 and 19, the adapter 20' includes: a first controller 51', multiple sets of ADC units 52' connected to the first controller 51', multiple sets of voltage-reducing resistors 53' and multiple sets of control switches 54' corresponding to the multiple sets of ADC units 52', multiple sets of bidirectional switching switches 55' connected to the multiple sets of ADC units 52', a first communication unit 56', and a power supply switch 40' for each set of ADC units 52'.The bidirectional switching switch 55' is connected to a multi-channel alternating power supply line 57' and a first power module 58', which is simultaneously connected to the first communication unit 56', the first controller 51', and multiple ADC units 52'. The first power module 58' provides DC power VCC to the various electronic components of the adapter 20'. The adapter 20' also includes multiple circuit lines (unlabeled), which are electrically connected to the multi-channel grounding line 18' and the multi-channel dual-purpose signal line 19' in the substrate 31' of the corresponding electrode plate 13' through the first cable 15' of the corresponding electrode plate 13'. The multiple circuit lines (unlabeled) include multiple alternating power supply lines 57' that transmit alternating electrical signals to the corresponding electrode 13' and are electrically connected to the multi-purpose signal lines 19' in the substrate 31' of the corresponding electrode 13'; multiple circuit lines (unlabeled) that are electrically connected one-to-one with the multi-purpose signal lines 19' in the substrate 31' of the corresponding electrode 13' and are used to power each temperature detection unit 35' of the electrode 13' or transmit the temperature detection signal of the electrode 13'; and multiple circuit lines (unlabeled) that are electrically connected one-to-one with the multiple grounding lines 18' in the substrate 31' of the corresponding electrode 13'. The number L of circuit lines electrically connecting adapter 20' to one electrode piece 13' is equal to the sum of the number of rows and columns of electrode units 33' of electrode piece 13'; the number H of circuit lines electrically connecting adapter 20' to X electrode pieces 13' is equal to X times the number of circuit lines electrically connecting it to a single electrode piece 13', i.e., H = XL = X × (M + N). The number of groups of control switches 54' and bidirectional switching switches 55' is related to the number of electrode pieces 13'. The number of groups of control switches 54' is the same as the number of groups of bidirectional switching switches 55', and not less than the number of electrode pieces 13'. Optionally, the number of groups of control switches 54' and bidirectional switching switches 55' is the same as the number of electrode pieces 13'.

[0311] For example, each group of control switches 54' is provided with multiple control switches 54', which are respectively connected to the adapter 20' and electrically connected to the circuit lines (unlabeled) corresponding one-to-one with the multiple grounding wires 18' of a corresponding electrode piece 13', and are configured to control the conduction or disconnection of the multiple grounding wires 18'. The circuit lines (unlabeled) that are electrically connected one-to-one with the multiple grounding wires 18' of the electrode piece 13' are grounded at the end near the control switch 54'. The number of control switches 54' in each group of control switches 54' is related to the number of grounding wires 18' of the substrate 31' of the corresponding electrode piece 13', and the two are equal in the embodiment of this specification 34 / 46 pages 37 CN 121371479 A. As shown in FIG18, in this embodiment, the multiple control switches 54' are respectively the first control switch 54-1', second control switch 54-2', third control switch 54-3', and fourth control switch 54-4'. Multiple control switches 54' in the same group each control the opening or closing of the corresponding grounding wire 18' of the same electrode piece 13'. The first control switch 54-1' controls the opening or closing of the first grounding wire 18-1' of the corresponding electrode piece 13', and can cooperate with the corresponding group of bidirectional switching switches 55' to control the energization and de-energization of the temperature detection units 35' corresponding to the five electrode units 33' in the first row group 33 of the electrode piece 13'; the second control switch 54-2' controls the opening or closing of the second grounding wire 18-2' of the electrode piece 13', and can cooperate with the corresponding group of bidirectional switching switches 55' to control the energization and de-energization of the electrode piece 13'. The temperature detection units 35' corresponding to the five electrode units 33' in the second row group 33' are energized and de-energized. A third control switch 54-3' controls the opening or closing of the third grounding wire 18-3' of the electrode plate 13', and can cooperate with the corresponding bidirectional switching switch 55' to control the energization and de-energization of the temperature detection units 35' corresponding to the five electrode units 33' in the third row group 33' of the electrode plate 13'. A fourth control switch 54-4' controls the opening or closing of the fourth grounding wire 18-4' of the electrode plate 13', and can cooperate with the corresponding bidirectional switching switch 55' to control the energization and de-energization of the temperature detection units 35' corresponding to the five electrode units 33' in the fourth row group 33' of the electrode plate 13'. The aforementioned control switch 54' can be a mechanical switch, such as a relay. The control switch 54' can also be an electronic switch, and each control switch 54' can be opened and closed by an additional first controller 51'.

[0312] In this embodiment, all sets of control switches 54' are electronic switches. The first controller 51' is communicatively connected to the multiple sets of control switches 54', and is used to sequentially and cyclically control the opening and closing states of multiple control switches 54' in each set of control switches 54', thereby sequentially and individually turning on each grounding wire 18' of the multiple grounding wires 18' of the corresponding electrode 13' and cooperating with the switching of the corresponding bidirectional switching switch 55' to collect the temperature of the patient's body surface detected by all temperature detection units 35' on the electrode 13'. The number of each set of control switches 54' is not less than the number of grounding wires 18' of the substrate 31' of the corresponding electrode 13'. In this embodiment, the number of each set of control switches 54' is the same as the number of grounding wires 18' of the corresponding electrode 13'.

[0313] Each set of bidirectional switching switches 55' is provided with multiple bidirectional switching switches 55', and the multiple bidirectional switching switches in each setEach of the 55's is connected to the adapter 20' and electrically connected to the circuit line (unlabeled) corresponding to the multi-purpose signal line 19' of the corresponding electrode 13'. The number of bidirectional switches 55' in each group of bidirectional switches 55' is related to the number of dual-purpose signal lines 19' of the substrate 31' of the corresponding electrode 13', which is greater than or equal to the number of dual-purpose signal lines 19' of the substrate 31' of the corresponding electrode 13'. In this embodiment, the two are equal. Each bidirectional switch 55' has two ends labeled 1 and 2. The signal acquisition terminals 1 of multiple bidirectional switches 55' in the same group are electrically connected to the corresponding detection channels of multiple detection channels of the corresponding group of ADC units 52' through temperature sampling points (unlabeled). The signal input terminal 2 of each bidirectional switch 55' in the same group is electrically connected to the corresponding different alternating power lines 57' and is configured to control the multi-channel dual-purpose signal line 19' to connect to the corresponding different alternating power lines 57' to transmit alternating electrical signals or to connect to the corresponding detection channel of the corresponding group of ADC units 52' to receive the temperature detection signal output by the temperature detection unit 35'.

[0314] As shown in FIG18, taking the electrical connection of an electrode plate 13' with an adapter 20' as an example, in this embodiment with 20 electrode units 33', the multiple bidirectional switching switches 55' are respectively the first bidirectional switching switch 55-1', the second bidirectional switching switch 55-2', the third bidirectional switching switch 55-3', the fourth bidirectional switching switch 55-4', and the fifth bidirectional switching switch 55-5'. The multiple bidirectional switching switches 55' in the same group control the switching of a corresponding dual-purpose signal line 19' in the same electrode plate 13' between transmitting alternating electrical signals and transmitting temperature detection signals. Specifically, the first bidirectional switching switch 55-1' is used to control the switching between the first dual-purpose signal line 19-1' of the corresponding electrode plate 13' and the temperature detection signal output from the alternating power supply line 57-1', thereby controlling the switching between the conduction of each electrode unit 33' of the electrode units 33-1', 33-6', 33-11', and 33-16' in the first column of the electrode plate 13' and the conduction of the signal terminal 35-2' of each temperature detection unit 35' corresponding to the electrode units 33-1', 33-6', 33-11', and 33-16' in the first column of the electrode plate 13', and cooperating with the corresponding control switches 54-1', 54-2', 54-3', and 54-4', so that the first column of electrode units 33-1', 33-6', 33-11', and 33-16', and the corresponding temperature detection units 35' in the first column of the electrode unit 33-1', 33-6', 33-11', and 33-16', are connected. Electrode units 6', 33-11', and 33-16' transmit individual alternating electrical signals to the patient or to the corresponding ADC unit 52'.The temperature detection signals collected by the temperature detection units 35' corresponding to the electrode units 33' are output; the second bidirectional switch 55-2' is used to control the switching between the alternating current signal output from the alternating power supply line 57-2' and the temperature detection signal of the corresponding electrode sheet 13', thereby controlling the conduction of each electrode unit 33' of the second column group of electrode units 33-2', 33-7', 33-12', and 33-17' and the conduction of the signal terminals 35-2' of the corresponding temperature detection units 35' of the second column group of electrode units 33-2', 33-7', 33-12', and 33-17', and the switching between the two, and the corresponding control switches 54-1' and 54-2'. 2', Control switches 54-3' and 54-4' cooperate to enable the second column of electrode units 33-2', 33-7', 33-12', and 33-17' to transmit individual alternating electrical signals to the patient or output temperature detection signals collected by the temperature detection units 35' corresponding to these electrode units 33' to the corresponding ADC unit 52'; the third bidirectional switching switch 55-3' is used to control the switching of the third dual-purpose signal line 19-3' of the corresponding electrode pad 13' between the alternating electrical signal output from the alternating power supply line 57-3' and the temperature detection signal, thereby controlling the conduction of each electrode unit 33' in the third column of electrode units 33-3', 33-8', 33-13', and 33-18' in the third column of electrode pad 13' and the corresponding temperature detection signals. The signal terminal 35-2' of the detection unit 35' switches between the two and cooperates with the corresponding control switches 54-1', 54-2', 54-3', and 54-4' to enable the third column of electrode units 33-3', 33-8', 33-13', and 33-18' to transmit individual alternating electrical signals to the patient or output temperature detection signals collected by the temperature detection unit 35' corresponding to these electrode units 33' to the corresponding ADC unit 52'. The fourth bidirectional switching switch 55-4' is used to control the switching of the fourth dual-purpose signal line 19-4' of the corresponding electrode piece 13' between the alternating electrical signal output from the alternating power supply line 57-4' and the temperature detection signal, thereby controlling the conduction of each electrode unit 33' in the fourth column of the electrode piece 13' and the electrode units 33-4' in the fourth column of the electrode piece 13'.The signal terminals 35-2' of each temperature detection unit 35' corresponding to unit 33-4', electrode unit 33-9', electrode unit 33-14', and electrode unit 33-19' are switched between the two and cooperate with the corresponding control switches 54-1', 54-2', 54-3', and 54-4', so that the fourth column of electrode units 33-4', electrode unit 33-9', electrode unit 33-14', and electrode unit 33-19' transmit individual alternating electrical signals to the patient or output temperature detection signals collected by the temperature detection units 35' corresponding to these electrode units 33' to the corresponding ADC unit 52'; the fifth bidirectional switching switch 55-5' is used to control the switching of the fifth dual-purpose signal line 19-5' of the corresponding electrode piece 13' between the alternating electrical signal output from the alternating power supply line 57-5' and the temperature detection signal, thereby controlling the electrode units 33-5' and electrode units 33-9' in the fifth column of the electrode piece 13'. The conduction of each electrode unit 33' of electrode units 33-15' and 33-20' in the fifth column group is switched with the signal terminal 35-2' of each temperature detection unit 35' corresponding to electrode units 33-5', 33-10', 33-15', and 33-20'. This switch is coordinated with the corresponding control switches 54-1', 54-2', 54-3', and 54-4' to enable the fifth column of electrode units 33-5', 33-10', 33-15', and 33-20' to transmit individual alternating electrical signals to the patient or output temperature detection signals collected by the temperature detection units 35' corresponding to these electrode units 33' to the corresponding ADC unit 52'. When the signal input terminal 2 of each bidirectional switching switch 55' is on and the signal acquisition terminal 1 is off, alternating electrical signals can be transmitted to each electrode unit 33' of each column of the corresponding electrode plate 13' through different alternating power lines 57'. When the signal acquisition terminal 1 of each bidirectional switching switch 55' is on and the signal input terminal 2 is off, it can cooperate with each control switch 54' in the corresponding group of control switches 54' to transmit the temperature detection signals collected by the temperature detection unit 35' corresponding to each electrode unit 33' on the electrode plate 13' in a time-division manner. The bidirectional switching switch 55' can be a mechanical switch, such as a relay. The bidirectional switching switch 55' can also be an electronic switch, and each bidirectional switching switch 55' can be switched by an additional first controller 51'.

[0315] In this embodiment, all of the bidirectional switching switches 55' are electronic switches. The first controller 51' is communicatively connected to multiple sets of bidirectional changeover switches 55', and is used to control the multiple bidirectional changeover switches 55' in each set of bidirectional changeover switches 55' in their respective...The signal acquisition terminal 1 and the signal input terminal 2 are switched, and the corresponding control switch 54' is closed or opened to continuously monitor the temperature of the patient's body surface detected by all temperature detection units 35' on the electrode 13' or to transmit alternating electrical signals to the patient.

[0316] In this embodiment, each group of ADC units 52' is electrically connected to the signal acquisition terminal 1 of multiple bidirectional switching switches 55' in the corresponding group of bidirectional switching switches 55' through multiple circuit lines (unlabeled) in the adapter 20', and is configured to receive the temperature detection signal transmitted by the multi-channel dual-purpose signal line 19' of the corresponding electrode 13', and convert the temperature detection signal from analog signal to digital signal. Each group of ADC units 52' includes multiple detection channels A, B, C, D, E, and each detection channel A, B, C, D, E is used to connect to one corresponding dual-purpose signal line 19' in the multi-channel dual-purpose signal line 19' through the corresponding bidirectional switching switch 55'. As shown in Figure 18, each ADC unit 52' contains five detection channels A, B, C, D, and E, which are respectively the first detection channel A, the second detection channel B, the third detection channel C, the fourth detection channel D, and the fifth detection channel E. The first detection channel A is connected to the first dual-purpose signal line 19-1' through the signal acquisition terminal 1 of the first bidirectional switch 55-1'; the second detection channel B is connected to the second dual-purpose signal line 19-2' through the signal acquisition terminal 1 of the second bidirectional switch 55-2'; the third detection channel C is connected to the third dual-purpose signal line 19-3' through the signal acquisition terminal 1 of the third bidirectional switch 55-3'; the fourth detection channel D is connected to the fourth dual-purpose signal line 19-4' through the signal acquisition terminal 1 of the fourth bidirectional switch 55-4'; and the fifth detection channel E is connected to the fifth dual-purpose signal line 19-5' through the signal acquisition terminal 1 of the fifth bidirectional switch 55-5'. Each detection channel A, B, C, D, and E is used to receive the temperature detection signal collected by the temperature detection unit 35' corresponding to the electrode unit 33' connected to the corresponding dual-purpose signal line 19'. Additionally, each detection channel A, B, C, D, and E is connected via a corresponding voltage divider resistor 53' within the adapter 20' to a first power module 58' that provides detection voltage to that detection channel A, B, C, D, and E. The first power module 58' provides DC power.

[0317] In this embodiment, the first communication unit 56' is configured to acquire digital signals output by multiple ADC units 52' and send the digital signals to the electric field generator 30'. The electric field generator 30' is also configured to control and adjust the voltage of the alternating electrical signal provided to the multiple electrode units 33' of the electrode sheet 13' according to the received digital signals. For example, when any of the received digital signals exceeds a preset threshold, it indicates that at least one electrode unit 33' in the electrode sheet 13' is emitting a voltage exceeding a preset threshold.If the temperature detected by the corresponding temperature detection unit 35' exceeds the preset threshold temperature (e.g., 41℃, 42℃, etc.), the voltage of the alternating electrical signal output by the electric field generator 30' can be appropriately reduced or stopped to avoid the electrode unit 33' of the electrode sheet 13' becoming too hot when the alternating electrical signal is applied, causing low-temperature burns to the patient's skin. The aforementioned preset threshold temperature and preset threshold can be determined according to human safety thresholds. The first communication unit 56' is controlled by the first controller 51' and serially transmits digital signals converted by multiple ADC units 52'. In this embodiment, the preset threshold temperature can be a value within the range of 36℃-45℃.

[0318] Referring to FIG18, in this embodiment, the first power module 58' is electrically connected to the second power module 32' of the electric field generator 30' and is configured to supply power to the first controller 51', multiple ADC units 52', and the first communication unit 56' of the adapter 20'. Each electrode 13' is connected to the adapter 20' via a first connector 60', as described in the specification (pages 37 / 46, CN 121371479 A). The first connector 60' is adapted to connect the corresponding electrode 13' to the adapter 20'. A second connector 70' is provided between the adapter 20' and the electric field generator 30', adapted to connect the electric field generator 30' to the adapter 20'. The adapter 20' also includes a second cable 25' connected to the second connector 70'. The second connector 70' includes a second plug 71' located at the end of the second cable 25' furthest from the first controller 51' and a second socket 72' on the electric field generator 30'. The second plug 71' and the second socket 72' are push-button spring connectors, meaning the second connector 70' connects the adapter 20' and the electric field generator 30' using a plug-in method. Each first connector 60', such as X1, Y1, X2, and Y2, is connected to the second connector 70' via corresponding five alternating power lines 57'. The first connectors 60', such as X1, Y1, X2, and Y2, are also connected to a corresponding set of control switches 54' and a corresponding set of ADC units 52'. Each first connector 60' is connected to the second connector 70' and the corresponding set of ADC units 52' via a corresponding set of bidirectional switching switches 55'. The second cable 25' has eight wires, including four five-core wires 1 to 4, each electrically connected to one of the corresponding five alternating power lines 57' for transmitting different alternating electrical signals; one wire 5 electrically connected to the data receiving line RX' of the first communication unit 56'; one wire 6 electrically connected to the data transmitting line TX' of the first communication unit 56'; one wire 7 electrically connected to the VCC power line of the first power module 58'; and one wire 8 electrically connected to the GND line of the first power module 58'. The second connector 70' and the first communication unit 56' are connected via...The data receiving line RX' and the data transmitting line TX' are connected. The VCC pin of the second connector 70' is connected to the VVC power line of the first power module 58'. The GND pin of the second connector 70' is connected to the GND line of the first power module 58' and grounded. The VCC pin of the second connector 70' is also connected to the corresponding group voltage resistors 53' and the corresponding group ADC units 52' through the VCC power line of the first power module 58'.

[0319] Referring to Figures 18 and 20, the electric field generator 30' includes: a second power module 32', a second controller 37', an AC signal generator 39', a second communication unit 38', and multiple power supply switches 40'. The VCC pin of the second connector 70' is also electrically connected to the VCC power line of the second power module 32'. The GND pin of the second connector 70' is grounded through the GND line of the second power module 32'. The second power module 32' is also connected to and supplies power to the second controller 37' and the AC signal generator 39', respectively. The second communication unit 38' is electrically connected to wire 5 of the second connector 70' via its data receiving line RX' and to wire 6 of the second connector 70' via its data transmitting line TX', thereby enabling information exchange between the electric field generator 30' and the adapter 20'. The second controller 37' is also electrically connected to the second communication unit 38', the AC signal generator 39', and multiple sets of power supply switches 40'. The second controller 37' is configured to control the opening and closing of each power supply switch 40' in each set of power supply switches 40' and adjust the relevant parameters of different alternating electrical signals applied by the AC signal generator 39' based on the relevant digital signals received from the adapter 20' by the second communication unit 38'. The AC signal generator 39 is electrically connected to wires 1 to 4 of the multiple sets of power supply switches 40' and the second connector 70' to transmit different alternating electrical signals. Each of the multiple sets of power supply switches 40' includes multiple power supply switches 40', and the multiple sets of power supply switches 40' are arranged one-to-one with multiple electrode plates 13'. Each set of power supply switches 40' is electrically connected to a corresponding five-core wire 1, 2, 3, 4 in the second connector 70' via a five-core AC power cable 41-1', 41-2', 41-3', 41-4', and then electrically connected to the corresponding electrode plate 13' via the corresponding five-core wire 1, 2, 3, 4 in the second connector 70', so as to transmit different alternating electrical signals to each electrode plate 13'. The AC signal generator 39' is electrically connected to the multiple sets of power supply switches 40' via a five-core AC power cable 41'. Specifically, the number of sets of power supply switches 40' in the electric field generator 30' is related to the number of electrode plates 13'. In this embodiment, the number of sets of power supply switches 40' is equal to the number of electrode plates 13', and both are 4. The number of each set of power supply switches 40' corresponds to the number of electrode plates 13'.Related to the number of columns of the electrode 13', in this embodiment, the number of each group of power supply switches 40' is equal to the number of columns of the corresponding electrode 13', and both are 5. The multiple groups of power supply switches 40' include a first group of power supply switches 40-1', a second group of power supply switches 40-2', a third group of power supply switches 40-3', and a fourth group of power supply switches 40-4', which are electrically connected one-to-one with the five-core wires 1 to 4 of the second connector 70'. One end of the first power supply switch 40-1' is electrically connected to the AC signal generator 39' via the five-core AC power cable 41' of the electric field generator 30' (see page 38 / 46 of the manual, CN 121371479 A). The other end is electrically connected to the corresponding five-core wire 1 for transmitting alternating electrical signals in the second connection 70' via a five-core AC power cable 41-1'. It is also electrically connected to the five-channel alternating power cable 57' at port X1' of the adapter 20' via the five-core wire 1 of the second connector 70'. The five-channel alternating power cable 57' at port X1' of the adapter 20' is electrically connected to the first connector 60'. The first connector 60' at port X1 of the adapter 20' is electrically connected to the corresponding electrode plate 13'. The AC signal generator 39' controls whether to supply different alternating electrical signals to the electrode units 33' in the five columns of the electrode plates 13' corresponding to the five alternating power lines 57' at the port X1 of the adapter 20'; one end of the second power supply switch 40-2' is electrically connected to the AC signal generator 39' through the five-core AC power line 41' of the electric field generator 30', and the other end is electrically connected to the corresponding five-core wire 2 for transmitting alternating electrical signals in the second connection 70' through a five-core AC power line 41-2', and electrically connected to the five-core power lines 57' at the port Y1' of the adapter 20' through the five-core wire 2 of the second connector 70', the five-core power lines 57' at the port Y1' of the adapter 20' are electrically connected to the first connector 60', and the five-core power lines 57' at the port Y1' of the adapter 20' are electrically connected to the first connector 60', and the five-core power lines 57' at the port Y1' of the adapter are electrically connected to the first connector 60'. The first connector 60' at port Y1' of adapter 20' is electrically connected to the corresponding electrode piece 13' to control whether the AC signal generator 39' supplies different alternating electrical signals to the electrode units 33' in the five columns of the electrode piece 13' corresponding to the five alternating power lines 57' at port Y1' of adapter 20'; one end of the third power supply switch 40-3' is electrically connected to the AC signal generator 39' through the five-core AC power line 41' of the electric field generator 30', and the other end is electrically connected to the corresponding five-core wire 3' transmitting alternating electrical signals in the second connection 70' through a five-core AC power line 41-3', and electrically connected to the five alternating power lines 57' at port X2' of adapter 20' through the five-core wire 3' of the second connector 70', the five alternating power lines 57' at port X2' of adapter 20' are electrically connected to the first connector 60', and the first connector 60' at port X2' of adapter 20' is electrically connected to the first connector 60'.Connector 60' is electrically connected to the corresponding electrode 13' to control whether AC signal generator 39' supplies different alternating electrical signals to electrode units 33' in the five columns of the electrode 13' corresponding to the five alternating power lines 57', which are electrically connected to port X2' of adapter 20'. One end of the fourth power supply switch 40-4' is electrically connected to AC signal generator 39' through the five-core AC power line 41' of electric field generator 30', and the other end is electrically connected to the corresponding five-core wire 4' transmitting alternating electrical signals in the second connection 70' through a five-core AC power line 4, and electrically connected to the five alternating power lines 57' located at port Y2' of adapter 20' through the five-core wire 4 of the second connector 70'. The five alternating power lines 57' located at port Y2' of adapter 20' are also connected to the five-core AC power lines 57'. The first connector 60', which is electrically connected to the first connector 60' and located at port Y2' of the adapter 20', is electrically connected to the corresponding electrode plate 13' to control whether the AC signal generator 39' supplies different alternating electrical signals to the electrode units 33' in the five columns of the electrode plate 13' that are electrically connected to port Y1' of the adapter 20', corresponding to the five alternating power lines 57'.

[0320] The working principle of the tumor electric field therapy system 100' of this embodiment will be described in detail below with reference to Figures 18 to 20.

[0321] It should be noted that the working principle of temperature acquisition of the tumor electric field therapy system 100' is the same as that of temperature acquisition of the tumor electric field therapy system 100, and will not be repeated here.

[0322] The working principle of applying alternating electrical signals of the tumor electric field therapy system 100' is similar to that of applying alternating electrical signals of the tumor electric field therapy system 100, the difference being that: in this embodiment, different alternating electrical signals can be applied to the electrode units 33 in different columns at the same time, which is more flexible.

[0323] Specifically, when it is necessary to apply alternating electrical signals to each electrode unit 33' of a certain electrode plate 13', the first controller 51' of the adapter 20' or the second controller 37' of the electric field generator 30' controls the signal input terminal 2 of each of the multiple bidirectional switching switches 55' electrically connected to the electrode plate 13' to be turned on and the signal acquisition terminal 1 to be turned off, and controls a set of power supply switches 40' electrically connected to the electrode plate 13' to be turned on. At this time, the second controller 37' of the electric field generator 30' controls the AC signal generator 39' to apply different alternating electrical signals to each column of electrode units 33' of the electrode plate 13' through different alternating power lines 57', and the magnitude of the voltage or current of the different alternating electrical signals applied is adjustable. That is, the switching unit (unlabeled) is configured to switch the dual-purpose signal lines 19 corresponding to at least two column groups to the specification page 39 / 46 42 CN 121371479 ADifferent alternating power lines 57' are used so that each electrode unit 33 in each column group is subjected to different alternating electrical signals based on different alternating power lines 57'.

[0324] It should be noted that in some other embodiments, a set of bidirectional switching switches 55' electrically connected to a certain electrode piece 13' can also be controlled by the first controller 51' of the adapter 20' or the second controller 37' of the electric field generator 30' to apply different alternating electrical signals to some electrode units 33' of the electrode piece 13' in the same time period. For example, the first controller 51' of the adapter 20' or the second controller 37' of the electric field generator 30' controls the signal input terminal 2 of the first bidirectional switch 55-1' of a set of bidirectional switches 55' electrically connected to the electrode 13' to be turned on and the signal acquisition terminal 1 to be turned off. It also controls the one power supply switch 40' corresponding to the first bidirectional switch 55-1' of a set of power supply switches 40' electrically connected to the electrode 13' to be turned on. At this time, the second controller 37' of the electric field generator 30' controls the AC signal generator 39' to apply an alternating electrical signal to the first column of electrode units 33-1', 33-6', 33-11' and 33-16' of the electrode 13' through the corresponding alternating power line 57'. The magnitude of the applied alternating electrical signal voltage or current is adjustable. It should be noted that in some other embodiments, different alternating electrical signals can be applied to two, three, or four groups of electrode units 33 simultaneously within the same time period. Details will not be elaborated here.

[0325] It should be noted that in this embodiment, the control switch 54', which is electrically connected to the multiple grounding lines 18' of the electrode piece 13', and the bidirectional switching switch 55', which is electrically connected to the multiple dual-purpose signal lines 19' of the electrode piece 13', are both located in the adapter 20'. However, in other embodiments, the control switch 54', which is electrically connected to the grounding line 18', and the bidirectional switching switch 55', which is electrically connected to the dual-purpose signal lines 19', can also be located on the electrode piece 13' or in the electric field generator 30'. Further details will not be elaborated here. In addition, the ADC unit 52' located in the adapter 20' can also be located in the electric field generator 30' and directly controlled by the second controller 37'.

[0326] The tumor electric field therapy system 100' of this application can achieve real-time and comprehensive temperature monitoring of all electrode units 33' on the electrode sheet 13' without increasing the weight of the electrode sheet 13' or increasing the number of wire cores in the first cable 15' electrically connected to the electrode sheet 13'. Therefore, it can determine whether the electrode sheet 13' is qualified based on the obtained temperature detection signal; or it can determine whether the temperature detection unit 35' of the electrode sheet 13' is faulty or abnormal based on the obtained temperature detection signal.The system can determine whether electrode 13' needs to be replaced based on the number of faulty or abnormal temperature detection units 35' obtained; or, if electrode 13' is qualified, it can identify the type of electrode based on the obtained temperature detection signal; or, if electrode 13' is qualified, it can determine whether the electrode unit 33' of electrode 13' is overheated based on the obtained temperature detection signal, and then control the alternating electrical signal applied to electrode 13' or the corresponding column of electrode units 33' of electrode 13' to avoid low-temperature burns to the patient's body surface during tumor treatment through electrode 13'. Furthermore, the substrate 31' of the electrode sheet 13' of this application is electrically connected to the signal terminals 35-2' of the same electrode unit 33' and its corresponding temperature detection unit 35' simultaneously via the same dual-purpose signal line 19'. This allows for the transmission of both alternating current signals and DC signals for temperature signal acquisition, along with the acquired temperature detection signals, via the dual-purpose signal line 19'. Simultaneously, it significantly reduces the number of conductive traces (grounding line 18', dual-purpose signal line 19') on the substrate 31', lowering the wiring complexity, simplifying the manufacturing process, reducing the weight of the substrate 31', and lowering manufacturing costs. The electrode sheet 13' of this application can also switch between applying alternating current signals for tumor treatment and transmitting DC signals for temperature acquisition and the acquired temperature detection signals through a combination of control switch 54' electrically connected to its grounding line 18' and bidirectional switching switch 55' electrically connected to the dual-purpose signal line 19'.

[0327] Specifically, when it is necessary to apply alternating electrical signals to the patient through each electrode unit 33' of a certain electrode 13', the first controller 51' of the adapter 20' or the second controller 37' of the electric field generator 30' controls all the control switches 54' in a set of control switches 54' corresponding to the electrode 13' to be turned off, and at the same time controls all the bidirectional switching switches 55' in a set of bidirectional switching switches 55' corresponding to the electrode 13' to be switched to their respective signal input terminals 2, so that the signal acquisition terminals 1 of these bidirectional switching switches 55' are all turned off and the signal input terminals 2 are all turned on, so that each dual-purpose signal line 19' of the electrode 13' is electrically connected to the adapter 20' and the corresponding multi-channel alternating power supply line 57' of the electrode 13', thereby transmitting the same or different alternating electrical signals to each electrode unit 33' of the electrode 13'. When the temperature detection signal of the temperature detection unit 35' corresponding to all electrode units 33' of the detected electrode sheet 13' is much lower than the preset temperature threshold stored in the electric field generator 30' or the adapter 20', the electric field generator 30' controls the AC signal generator 39 to continue through its second controller 37'.An alternating electrical signal with increased or constant voltage or current amplitude is generated and transmitted to the corresponding counter electrode 13' via the corresponding multiplexed alternating power supply line 57' of the adapter 20', so that the alternating electrical signal continues to be applied to the counter electrode 13'. When the temperature detection signal of the temperature detection unit 35' corresponding to all electrode units 33' of the detected electrode 13' is lower than but close to the preset temperature threshold stored in the electric field generator 30' or the adapter 20', the electric field generator 30' can reduce the voltage or current of the alternating electrical signal generated by the AC signal generator 39' through the second controller 37', thereby reducing the voltage or current of the alternating electrical signal applied to the counter electrode 13'. When an electrode unit 33 is detected on a certain electrode 13', the alternating electrical signal is applied to the counter electrode 13'. When the temperature detection signal of the corresponding temperature detection unit 35' exceeds the preset temperature threshold, the electric field generator 30' controls a set of power supply switches 40' electrically connected to the electrode 13' to disconnect via the second controller 37', thereby stopping the application of alternating electrical signals to the electrode 13'; or the second controller 37' of the electric field generator 30' or the first controller 21' of the adapter 20' controls all bidirectional switching switches 55' electrically connected to the electrode 13' to switch from their signal input terminal 2 to the signal acquisition terminal 1, that is, all bidirectional switching signals of all bidirectional switching signals of the set of bidirectional switching switches 55' electrically connected to the electrode 13' are turned on and all signal input terminals 2 are turned off. This allows for the cessation of applying alternating electrical signals to the electrode 13'; or, when a temperature detection signal from a temperature detection unit 35' corresponding to an electrode unit 33' on an electrode 13' is detected to be greater than a preset temperature threshold, the second controller 37' of the electric field generator 30' controls a set of power supply switches 40' electrically connected to the electrode 13' to remain on, and the second controller 37' of the electric field generator 30' or the first controller 21' of the adapter 20' controls a bidirectional switching switch 55' electrically connected to the electrode unit 33' on the electrode 13' to switch from its signal input terminal 2 to its signal acquisition terminal 1, and the second controller 37' of the electric field generator 30' or the first controller 21' of the adapter 20' controls a bidirectional switching switch 55' electrically connected to the electrode unit 33' on the electrode 13' to switch from its signal input terminal 2 to its signal acquisition terminal 1, and the second controller 37' of the electric field generator 30' or the first controller 21' of the adapter 20'... Simultaneously, all other bidirectional switching switches 55' electrically connected to electrode units 33' in different columns from those electrode units 33' whose temperature detection signals do not exceed the preset temperature threshold, and which are electrically connected to their respective signal input terminals 2, are kept electrically connected. This stops applying alternating electrical signals to all electrode units 33' in the same column as those electrode units 33' whose temperature detection signals exceed the preset temperature threshold, and continues to apply alternating electrical signals to the remaining columns of electrode units 33' whose temperature detection signals do not exceed the preset temperature threshold.The alternating electrical signal applied by element 33' can be the same or different. For example, for columns where the temperature detection signal is closer to the preset temperature threshold than the preset temperature threshold, the voltage or current amplitude of the alternating electrical signal is reduced; for columns where the temperature detection signal is further away from the preset temperature threshold than the preset temperature threshold, the voltage or current amplitude of the alternating electrical signal is increased. This realizes the alternating electrical signal application control method of the tumor electric field therapy system 100' based on the temperature detection signal.

[0328] It should be noted that the alternating electric signal application method, electrode temperature detection method, electrode temperature abnormality detection method, control method, and electrode type identification method of the tumor electric field therapy system 100' in this embodiment are similar to the control method of the aforementioned tumor electric field therapy system 100. The difference is that the tumor electric field therapy system 100' in this embodiment can also apply different alternating electric signals, such as different voltages or currents, to the electrode units 33' in each region (i.e., each column group) according to the temperature of the electrode units 33' in each region, to prevent the electrode units 33' in the corresponding region from exceeding the preset temperature threshold, so as to apply the electric field continuously for a long time and improve the treatment effect. Specification 41 / 46 pages 44 CN 121371479 A

[0329] Specifically, the tumor electric field therapy system 100' in this embodiment can use the electrode temperature detection method shown in FIG8 to determine the temperature of each electrode unit 33' in the electrode sheet 13'. For details, please refer to FIG8, which will not be repeated here.

[0330] The tumor electric field therapy system 100' of this embodiment can use the electrode temperature anomaly detection method shown in FIG9 to determine whether the electrode 13' is abnormal. For details, please refer to FIG9, which will not be repeated here.

[0331] The tumor electric field therapy system 100' of this embodiment can use the control method of the tumor electric field therapy system shown in FIG21 to control the intensity of the alternating electrical signal applied to the electrode unit 33', specifically including the following steps:

[0332] Step 210': Control the switching unit so that at least one column group of the corresponding electrode 13' is connected to the corresponding temperature sampling point.

[0333] Step 220': Control the control switch 54' corresponding to each row group so as to sample the analog temperature signal of the corresponding electrode unit 33' based on the corresponding temperature sampling point to determine the temperature detection signal of each electrode unit 33' in each electrode 13'.

[0334] Step 240': Control the intensity of the alternating electrical signal applied to the electrode unit 33' according to the temperature detection signal.

[0335] Specifically, when it is determined that the electrode sheet 13' does not need to be replaced, the alternating electrical signal applied to each electrode unit 33' in the electrode sheet 13' is controlled or adjusted according to the temperature detection signal detected by the temperature detection unit 35' corresponding to each electrode unit 33' in the electrode sheet 13'.

[0336] In some embodiments, controlling the intensity of the alternating electrical signal applied to the electrode unit 33' based on the temperature detection signal in step 240' specifically includes the following steps:

[0337] Step 241': Compare the temperature at each electrode unit 33' in the electrode sheet 13' with a preset temperature threshold based on the temperature detection signal.

[0338] Step 242': Control the intensity of the alternating electrical signal based on the comparison result.

[0339] In some embodiments, controlling the intensity of the alternating electrical signal based on the comparison result in step 242' specifically includes:

[0340] Step 2421': If the temperature at at least one electrode unit 33' exceeds the preset temperature threshold, stop applying the alternating electrical signal to the electrode unit 33' of the electrode sheet 13'. Specifically, when any temperature detection signal among all the acquired temperature detection signals of the electrode units 33' of the electrode sheet 13' exceeds the preset temperature threshold, stop applying the alternating electrical signal to the electrode unit 33' of the electrode sheet 13'. When the temperature detection signals of each electrode unit 33' in the electrode sheet 13' do not exceed the preset temperature threshold, alternating electrical signals continue to be applied to each electrode unit 33' in the electrode sheet 13'.

[0341] In some embodiments, stopping the application of alternating electrical signals to the electrode units 33' in step 2421' specifically includes: stopping the application of alternating electrical signals to all electrode units 33' in the electrode sheet 13'; or stopping the application of alternating electrical signals to all electrode units 33' in the column group where the electrode unit 33' exceeds the preset temperature threshold in the electrode sheet 13'.

[0342] Further, when the application of alternating electrical signals to all electrode units 33' in the column group where the electrode unit 33' exceeds the preset temperature threshold in the electrode sheet 13' is stopped, alternating electrical signals continue to be applied to the electrode units 33' in other columns in the electrode sheet 13'. The intensity of the alternating electrical signals applied to the electrode units 33' in other columns in the electrode sheet 13' is adjustable. For example, if the temperature detection signal in electrode sheet 13' does not exceed the preset temperature threshold and all electrode units 33' in different columns from the electrode units 33' whose temperature detection signal exceeds the preset temperature threshold are still subject to alternating electrical signals, and the alternating electrical signals applied to different columns can be the same or different. For example, the voltage or current amplitude of the alternating electrical signal applied to the column group that is closer to the preset temperature threshold but does not exceed the preset temperature threshold is smaller, and vice versa.

[0343] In some other embodiments, the control of the alternating electrical signal intensity in step 242' based on the comparison result specifically includes: Specification 42 / 46 pages 45 CN 121371479 A

[0344] Step 2422': If the temperature at all electrode units 33' in electrode sheet 13' does not exceed the preset temperature threshold, and if the temperature at all electrode units 33' in electrode sheet 13' does not exceed the first preset temperature, then the alternating electrical signal intensity is increased.The alternating electrical signal intensity applied to the electrode unit 33' of the electrode sheet 13', wherein the first preset temperature is less than the preset temperature threshold.

[0345] In step 2422', the increase in electric field intensity corresponding to each column group whose alternating electrical signal intensity is increased can be the same or different, that is, they can be adjusted separately. For example, the voltage or current amplitude of the alternating electrical signal applied to the column group with the lower highest temperature is larger, and vice versa.

[0346] Step 2423': If the temperature at all electrode units 33' in the electrode sheet 13' does not exceed the preset temperature threshold, and if the temperature at at least one electrode unit 33' in the electrode sheet 13' exceeds the first preset temperature but is less than the second preset temperature, then the alternating electrical signal intensity currently applied to the electrode unit 33' of the electrode sheet 13' remains unchanged.

[0347] In step 2423', keeping the alternating electrical signal intensity currently applied to electrode unit 33' unchanged specifically includes: keeping the alternating electrical signal intensity currently applied to the first target column group unchanged, wherein the first target column group is a column group where the temperature at electrode unit 33' exceeds a first preset temperature and is less than a second preset temperature. That is, only the voltage or current amplitude of the alternating electrical signal corresponding to the column group whose temperature exceeds the first preset temperature and is less than the second preset temperature can be kept unchanged, while the voltage or current amplitude of the alternating electrical signal corresponding to the other column groups can still be adjusted according to the temperature of the corresponding column group.

[0348] Step 2424': If the temperature at all electrode units 33' in electrode sheet 13' does not exceed the preset temperature threshold, and if the temperature at at least one electrode unit 33' in electrode sheet 13' exceeds the second preset temperature and is less than the preset temperature threshold, then the alternating electrical signal intensity applied to electrode unit 33' of electrode sheet 13' is reduced.

[0349] In step 2424', reducing the intensity of the alternating electrical signal applied to the electrode unit 33' specifically includes: reducing the intensity of the alternating electrical signal applied to the electrode units 33' of the second target column group, wherein the second target column group is a column group where the temperature at the electrode unit 33' exceeds a second preset temperature but is less than a preset temperature threshold. That is, only the voltage or current amplitude of the alternating electrical signal corresponding to the column group whose temperature exceeds the second preset temperature but is less than the preset temperature threshold can be reduced, and the reduced amplitude can be the same or different, while the voltage or current amplitude of the alternating electrical signal corresponding to the other column groups can still be adjusted according to the temperature of the corresponding column group, for example, maintained or increased.

[0350] For example, when the temperature detection signal is much lower than the preset temperature threshold, the alternating electrical signal is continued to be applied to each electrode unit 33' of the electrode sheet 13' by increasing the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33' of the electrode sheet 13', wherein the voltage or current amplitude of the alternating electrical signal applied to different column groups can be the same or different, orAn alternating electrical signal is continuously applied to each electrode unit 33' of the electrode plate 13' in a manner that maintains the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33' of the electrode plate 13' constant. The voltage or current amplitude of the alternating electrical signal applied to only a portion of the column groups may remain constant. When the temperature detection signal approaches a preset temperature threshold, an alternating electrical signal is continuously applied to each electrode unit 33' of the electrode plate 13' in a manner that maintains the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33' of the electrode plate 13' constant. The voltage or current amplitude of the alternating electrical signal applied to only a portion of the column groups may remain constant, or the alternating electrical signal may be applied to each electrode unit 33' of the electrode plate 13' in a manner that reduces the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33' of the electrode plate 13'. The voltage or current amplitudes of the alternating electrical signals applied to different column groups may be the same or different.

[0351] In some other embodiments, controlling the alternating electrical signal strength based on the comparison result in step 242' specifically includes:

[0352] Step 2425': If the temperature at at least one electrode unit 33' exceeds a preset temperature threshold, determine the number of over-temperature groups.

[0353] Step 2426': If the number of over-temperature groups exceeds a preset number threshold, stop applying alternating electrical signals to all electrode units 33'.

[0354] Step 2427': If the number of over-temperature groups does not exceed the preset number threshold, stop applying alternating electrical signals to all electrode units 33' in the group where the electrode unit 33' exceeding the preset temperature threshold is located.

[0355] Further, when the alternating electrical signal is stopped being applied to all electrode units 33' in the column group where the electrode unit 33' exceeds the preset temperature threshold in the electrode sheet 13', the alternating electrical signal continues to be applied to the electrode units 33' in other columns of the electrode sheet 13'. The intensity of the alternating electrical signal applied to the electrode units 33' in other columns of the electrode sheet 13' is adjustable. For example, all electrode units 33' in the electrode sheet 13' whose temperature detection signal does not exceed the preset temperature threshold and are in a different column from the electrode unit 33' whose temperature detection signal exceeds the preset temperature threshold are still subject to alternating electrical signals. The alternating electrical signals applied to different columns can be the same or different. For example, the voltage or current amplitude of the alternating electrical signal applied to the column group that is closer to the preset temperature threshold but does not exceed the preset temperature threshold is smaller, and vice versa.

[0356] Step 2428': If the number of overheated groups does not exceed a preset threshold, and the temperature at each electrode unit 33' in the non-overheated groups does not exceed a first preset temperature, then increase the pressure applied to the electrode units 33' in the non-overheated groups.The intensity of the alternating electrical signal is increased, wherein the first preset temperature is less than the preset temperature threshold.

[0357] In step 2428', the increase in electric field intensity corresponding to each column group whose alternating electrical signal intensity is increased can be the same or different, that is, they can be adjusted respectively. For example, the voltage or current amplitude of the alternating electrical signal applied to the column group with the lower highest temperature is larger, and vice versa.

[0358] Step 2429': If the number of over-temperature columns does not exceed the preset number threshold, and if the temperature at at least one electrode unit 33' in the non-over-temperature columns exceeds the first preset temperature but is less than the preset temperature threshold, then the alternating electrical signal intensity currently applied to the electrode unit 33' of the non-over-temperature columns remains unchanged.

[0359] In step 2429', keeping the alternating electrical signal intensity currently applied to electrode unit 33' unchanged specifically includes: keeping the alternating electrical signal intensity currently applied to the first target column group unchanged, wherein the first target column group is a column group where the temperature at electrode unit 33' exceeds a first preset temperature and is less than a preset temperature threshold. That is, only the voltage or current amplitude of the alternating electrical signal corresponding to the column group whose temperature exceeds the first preset temperature and is less than the preset temperature threshold can be kept unchanged, while the voltage or current amplitude of the alternating electrical signal corresponding to the other column groups can still be adjusted according to the temperature of the corresponding column group.

[0360] Step 2430': If the number of overheated column groups does not exceed a preset number threshold, and if at least one electrode unit 33' in the non-overheated column group has a temperature exceeding a second preset temperature and is less than a preset temperature threshold, then the alternating electrical signal intensity applied to the electrode unit 33' of the non-overheated column group is reduced, wherein the second preset temperature is greater than the first preset temperature and less than the preset temperature threshold.

[0361] In step 2430', reducing the intensity of the alternating electrical signal applied to the electrode unit 33' specifically includes: reducing the intensity of the alternating electrical signal applied to the electrode unit 33' of the second target column group, wherein the second target column group is a column group where the temperature at the electrode unit 33' exceeds a second preset temperature but is less than a preset temperature threshold. That is, only the voltage or current amplitude of the alternating electrical signal corresponding to the column group whose temperature exceeds the second preset temperature but is less than the preset temperature threshold can be reduced, and the reduced amplitude can be the same or different, while the voltage or current amplitude of the alternating electrical signal corresponding to the other column groups can still be adjusted according to the temperature of the corresponding column group, for example, maintained or increased.

[0362] For example, when the temperature detection signal is much lower than the preset temperature threshold, the alternating electrical signal is continued to be applied to each electrode unit 33' of the electrode plate 13' by increasing the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33' of the electrode plate 13'. The voltage or current amplitude of the alternating electrical signal applied to different columns can be the same or different, or the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33' of the electrode plate 13' can be kept constant.An alternating electrical signal continues to be applied to each electrode unit 33' of the electrode plate 13'. The amplitude of the voltage or current of the alternating electrical signal applied to only a portion of the column groups can remain constant. When the temperature detection signal approaches a preset temperature threshold, the alternating electrical signal continues to be applied to each electrode unit 33' of the electrode plate 13' in a manner that maintains the amplitude of the voltage or current of the alternating electrical signal applied to each electrode unit 33' of the electrode plate 13' constant. The amplitude of the voltage or current of the alternating electrical signal applied to only a portion of the column groups can remain constant, or the amplitude of the voltage or current of the alternating electrical signal applied to each electrode unit 33' of the electrode plate 13' can be reduced. The amplitudes of the voltage or current of the alternating electrical signal applied to different column groups can be the same or different.

[0363] The tumor electric field therapy system 100' of this embodiment can use the electrode type identification method shown in FIG11 to identify the type of electrode 13'. For details, please refer to FIG11, which will not be repeated here.

[0364] The tumor electric field therapy system 100' of this embodiment can use the tumor electric field therapy signal control method shown in FIG22 to combine and control the control switch 54' and the bidirectional switching switch 55' that are electrically connected to the electrode 13' so that each electrode unit 33' of the electrode 13' switches between applying an alternating electrical signal and collecting a temperature detection signal.

[0365] Referring to FIG22, the method includes:

[0366] Step 310': combining the control switch 54' and the bidirectional switching switch 55' electrically connected to the corresponding electrode sheet 13' to apply alternating electrical signals to each electrode unit 33' of the electrode sheet 13' and execute step 320';

[0367] Applying alternating electrical signals to each electrode unit 33' of the electrode sheet 13' in step 310' specifically includes: simultaneously applying the same or different alternating electrical signals to the electrode units 33' of some or all of the column groups in all column groups.

[0368] Step 320': Combine the control switch 54' and the bidirectional switching switch 55' electrically connected to the electrode sheet 13' to collect the temperature detection signals of each electrode unit 33' of the electrode sheet 13' in a row and execute step 330';

[0369] The process of collecting the temperature detection signals of each electrode unit 33' of the electrode sheet 13' in a row in step 320' specifically includes: sampling the temperature detection signals of all electrode units 33' of some or all row groups in all row groups in the same sampling time period; or sampling the temperature detection signals of some electrode units 33' of some or all row groups in all row groups in the same sampling time period.

[0370] Step 330': Determine the control switch 54' and the bidirectional switching switch 55' electrically connected to the electrode sheet 13' based on the collected temperature detection signals.The bidirectional switching switch 55' combines the control mode and executes step 340';

[0371] Step 340': Control the working state of each electrode unit 33' of the electrode sheet 13' according to the determined combination control mode of the control switch 54' and the bidirectional switching switch 55'.

[0372] The working state of each electrode unit 33' of the electrode sheet 13' in step 340' includes at least one of: stopping the application of alternating current signal and continuing to collect temperature detection signal, and stopping the collection of temperature detection signal and continuing to apply alternating current signal. Continuing to apply alternating current signal includes: continuing to apply alternating current signal by increasing the voltage or current amplitude of the currently applied alternating current signal, or continuing to apply alternating current signal by keeping the voltage or current amplitude of the currently applied alternating current signal unchanged, or continuing to apply alternating current signal by decreasing the voltage or current amplitude of the currently applied alternating current signal. Among them, the method of continuing to apply alternating current signal corresponding to different column groups can be the same or different.

[0373] The working state of each electrode unit 33' of the electrode sheet 13' is determined by the temperature detection signal it collects. Each electrode unit 33' of the electrode sheet 13' is divided into different regions. By controlling the combination of the control switch 54' and the bidirectional switching switch 55', each electrode unit 33' in each region can be cyclically switched between applying an alternating current signal and collecting a temperature detection signal. When applying an alternating current signal, different regions can be the same or different.

[0374] The tumor electric field therapy system 100' of this embodiment can use the electrode sheet temperature detection method shown in FIG13 to detect the temperature of the electrode sheet 13'. For details, please refer to FIG13, which will not be repeated here.

[0375] The tumor electric field therapy system 100' of this embodiment can apply an alternating electrical signal to the electrode 13' using the method of applying an alternating electrical signal as shown in Figures 14-16, page 45 / 46 of the instruction manual for tumor electric field therapy, CN 121371479 A. The difference is that when applying the alternating electrical signal, the alternating electrical signals applied to different columns can be the same or different, which will not be elaborated here.

[0376] This application also provides a tumor electric field therapy system 100 or 100', comprising: at least one pair of the aforementioned electrode pads 13 or 13'; an electric field generator 30 or 30', the electric field generator 30 or 30' being used to generate alternating power and transmit the alternating power to each electrode pad 13 or 13' via an alternating power line 57 or 57'; a control unit (such as a first controller 51 or 51' or a second controller 37 or 37', etc.), the control unit being used to configure at least one of the switching state of a control switch 54 or 54' and the switching state of a switching unit (unlabeled), so as to sample the analog temperature signal detected by the corresponding temperature detection unit 35 or 35' in each row group based on the corresponding temperature sampling point (unlabeled), or to control the electrode units 33 or 33' of at least one column group.An alternating electrical signal is applied to the alternating power line 57 or 57'.

[0377] This application also provides a tumor treatment device (not shown), including: the aforementioned tumor electric field therapy system 100 or 100'.

[0378] This application also provides a computer-readable storage medium storing a computer program thereon, which, when executed by a processor, implements the aforementioned electrode temperature detection method; or the aforementioned electrode abnormality detection method; or the aforementioned tumor electric field therapy system control method; or the aforementioned electrode type identification method.

[0379] This application also provides a tumor electric field therapy adapter 20 or 20', including a first memory (not shown) and a first controller 51 or 51', the first memory (not shown) storing a computer program, which, when executed by the first controller 51 or 51', implements the aforementioned electrode temperature detection method; or the aforementioned electrode abnormality detection method; or the aforementioned tumor electric field therapy system control method; or the aforementioned electrode type identification method.

[0380] This application also provides an electric field generator 30 or 30' for tumor electric field therapy, including a second memory (not shown) and a second controller 37 or 37'. The second memory (not shown) stores a computer program, which, when executed by the second controller 37 or 37', implements the aforementioned electrode temperature detection method; or the aforementioned electrode abnormality detection method; or the aforementioned control method for a tumor electric field therapy system; or the aforementioned electrode type identification method.

[0381] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and not to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features. These modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this application, and they should all be covered within the scope of the claims and specification of this application. In particular, as long as there is no structural conflict, the various technical features mentioned in the various embodiments can be combined in any way. This application is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims. Specification 46 / 46 pages 49 CN 121371479 A Figure 1 Specification Drawing 1 / 16 pages 50 CN 121371479 A Figure 2 Specification Drawing 2 / 16 pages 51 CN 121371479 A Figure 3 Specification Drawing 3 / 16 pages 52 CN 121371479 A Figure 4 Specification Drawing 4 / 16 pages 53 CN 121371479 A Figure 5 DescriptionFigure 5 / 16, page 54, CN 121371479 A, ​​Figure 6; Figure 6 / 16, page 55, CN 121371479 A, ​​Figure 7; Figure 8; Figure 7 / 16, page 56, CN 121371479 A, ​​Figure 9; Figure 10; Figure 11; Figure 8 / 16, page 57, CN 121371479 A, ​​Figure 12; Figure 13; Figure 14; Figure 9 / 16, page 58, CN 121371479 A, ​​Figure 15; Figure 10 / 16, page 59, CN 121371479 A, ​​Figure 16; Figure 11 / 16, page 60, CN 121371479 A, ​​Figure 17; Figure 12 / 16, page 61, CN 121371479 A, ​​Figure 18; Figure 13 / 16, page 62, CN 121371479 A, ​​Figure 19. Figure 14 / 16 of the specification, page 63 CN 121371479 A Figure 20 Figure 21 Figure 15 / 16 of the specification, page 64 CN 121371479 A Figure 22 Figure 16 / 16 of the specification, page 65 CN 121371479 A Abstract The present invention provides an electric field generator and a tumor electric field therapy system. A transducer array of the tumor electric field therapy system comprises a plurality of electrode units and a plurality of temperature detection units. The plurality of temperature detection units are divided into a plurality of row groups and a plurality of column groups. The grounding terminals of the respective temperature detection units in each row group are connected to a same grounding line,and the signal terminals of the respective temperature detection units in each column group are respectively short-circuited to the corresponding electrode units and then connected to a same dual-purpose signal line. The bidirectional change-over switches of the electric field generator are configured to selectively switch the dual-purpose signal lines to be connected to temperature sampling points or an alternating power line. When the dual-purpose signal lines are connected to the temperature sampling points, the grounding lines are sequentially conducted, so that temperature detection signals detected by the respective temperature detection units are sampled based on the temperature sampling points. When the dual-purpose signal lines are connected to the alternating power line, an alternating current signal is transmitted to the respective electrode units through the dual-purpose signal lines, thereby achieving zonal control and comprehensive temperature detection of the transducerarray.

Claims

1. An electric field generator, characterized in that, For providing alternating current signals to electrode pads in a tumor electric field therapy system, the electrode pads include multiple electrode units and multiple temperature detection units. Each electrode unit can be supplied with an alternating current signal, and each temperature detection unit is configured to detect the temperature at each electrode unit. The signal terminals of each temperature detection unit are short-circuited to the corresponding electrode unit. The multiple temperature detection units are configured in multiple row groups and multiple column groups. The ground terminals of temperature detection units in the same row group are short-circuited to the same grounding line. The ground terminals of temperature detection units in different row groups are connected in parallel through different grounding lines. The signal terminals of temperature detection units in the same column group are short-circuited to the same dual-purpose signal line. The signal terminals of temperature detection units in different column groups are... The terminals are connected in parallel via different dual-purpose signal lines; the electric field generator is equipped with multiple control switches and multiple bidirectional switching switches corresponding to the electrode plates, and each grounding wire of the electrode plate is grounded through a corresponding control switch, and each dual-purpose signal line is electrically connected to a corresponding bidirectional switching switch; wherein, the bidirectional switching switch is configured to switch each dual-purpose signal line to be connected to a temperature sampling point or an alternating power supply line, so that (1) when each dual-purpose signal line is connected to the temperature sampling point, each grounding wire is sequentially and individually turned on, so that the temperature detection signal detected by each temperature detection unit is sampled based on the corresponding temperature sampling point; (2) when the dual-purpose signal line is connected to the alternating power supply line, the alternating electrical signal is transmitted to each electrode unit through each dual-purpose signal line.

2. The electric field generator according to claim 1, characterized in that, Each of the grounding wires of the electrode sheet is connected in series with a corresponding control switch and grounded through the corresponding control switch; each of the dual-purpose signal lines of the electrode sheet is connected in series with a corresponding bidirectional switching switch, and each bidirectional switching switch is provided with a signal acquisition terminal connected to a temperature sampling point and a signal input terminal connected to the alternating power supply line.

3. The electric field generator according to claim 2, characterized in that, An ADC unit is provided, which has multiple detection channels. The signal acquisition terminal of each bidirectional switching switch is electrically connected to a corresponding detection channel through a corresponding temperature sampling point. The ADC unit is configured to sample the temperature detection signals of each temperature detection unit.

4. The electric field generator according to claim 1, characterized in that, Each of the dual-purpose signal lines is connected to a different alternating power supply line.

5. The electric field generator according to claim 1, characterized in that, Each of the dual-purpose signal lines is connected to the same alternating power supply line.

6. The electric field generator according to claim 1, characterized in that, The electric field generator has a preset temperature threshold and is configured to: when the temperature detection signal detected by each of the temperature detection units on the electrode sheet is much lower than the preset temperature threshold, control the dual-purpose signal line to transmit an AC signal with an increased or unchanged voltage or current amplitude to each of the electrode units.

7. The electric field generator according to claim 6, characterized in that, The electric field generator is configured to control the dual-purpose signal line to transmit an alternating electrical signal with reduced voltage or current amplitude to each of the electrode units when the temperature detection signal detected by the temperature detection unit is lower than but close to the preset temperature threshold.

8. The electric field generator according to claim 7, characterized in that, The electric field generator is configured to control the dual-purpose signal line to stop transmitting the AC signal to each of the electrode units when the temperature detection signal detected by the temperature detection unit is greater than the preset temperature threshold.

9. The electric field generator according to claim 8, characterized in that, The electric field generator is configured to: disconnect all dual-purpose signal lines from the alternating power supply line when the temperature detection signal detected by the temperature detection unit on the electrode sheet is greater than the preset temperature threshold, or disconnect only the dual-purpose signal line corresponding to the column group of the electrode unit with the temperature detection signal greater than the preset temperature threshold from the alternating power supply line while maintaining the connection of the remaining dual-purpose signal lines to the alternating power supply line.

10. The electric field generator according to claim 1, characterized in that, Each of the temperature detection signals is used to determine whether the electrode is qualified, whether the temperature detection unit of the electrode is faulty, whether the temperature detection unit of the electrode is abnormal, or whether the electrode needs to be replaced.

11. The electric field generator according to claim 10, characterized in that, Each of the temperature detection signals is used to identify the type of electrode sheet or to determine whether the electrode unit of the electrode sheet is overheated, provided that the electrode sheet is qualified.

12. A tumor electric field therapy system, characterized in that, It includes: An electrode sheet includes multiple electrode units and multiple temperature detection units. Each electrode unit can be supplied with an alternating electrical signal. Each temperature detection unit is configured corresponding to one of the electrode units to detect the temperature at that electrode unit. The signal terminals of each temperature detection unit are short-circuited to the corresponding electrode unit. The multiple temperature detection units are configured in the circuit as multiple row groups and multiple column groups. The ground terminals of the temperature detection units in the same row group are short-circuited to the same grounding line. The ground terminals of the temperature detection units in different row groups are connected in parallel through different grounding lines. The signal terminals of the temperature detection units in the same column group are short-circuited to the same dual-purpose signal line. The signal terminals of the temperature detection units in different column groups are connected in parallel through different dual-purpose signal lines. An electric field generator is provided with multiple control switches and multiple bidirectional switching switches corresponding to the electrode plates. Each grounding wire of the electrode plate is grounded through a corresponding control switch, and each dual-purpose signal line is electrically connected to a corresponding bidirectional switching switch. The bidirectional switching switch is configured to switch each dual-purpose signal line to a temperature sampling point or an alternating power supply line so that (1) when each dual-purpose signal line is connected to the temperature sampling point, each grounding wire is sequentially and individually turned on so that the temperature detection signal detected by each temperature detection unit is sampled based on the corresponding temperature sampling point; (2) when the dual-purpose signal line is connected to the alternating power supply line, an AC signal is transmitted to each electrode unit through the dual-purpose signal line.

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