Tumor electric field therapy system

Abstract

The invention provides a tumor electric field treatment system, which comprises an electrode plate and a controller, the electrode plate comprises a plurality of electrode units and a plurality of temperature detection units, the plurality of temperature detection units are divided into a plurality of row groups and a plurality of column groups, and the grounding ends of the temperature detection units in each row group are jointly connected to the same grounding wire. The signal end of each temperature detection unit in each column group is in short circuit with the corresponding electrode unit and then is connected to the same dual-purpose signal line; a direct current signal or an alternating current signal can be accessed to the dual-purpose signal line, and when the direct current signal is accessed to the dual-purpose signal line, all the grounding wires are sequentially conducted so that temperature detection signals detected by all the temperature detection units can be collected line by line; when the dual-purpose signal line is connected with an alternating-current electric signal, the alternating-current electric signal is transmitted to each electrode unit. In this way, temperature detection and zone control can be performed on the electrode plate by using fewer conductive traces.

Description

(19) State Intellectual Property Office (12) Invention Patent Application (10) Application Publication Number (43) Application Publication Date (21) Application Number 202511686331.X (22) Application Date 2024.10.25 (66) Domestic Priority Data 202311809226.1 2023.12.26 CN (62) Divisional Application Data 202411499593.0 2024.10.25 (71) Applicant Jiangsu Hailai Xinchuang Medical Technology Co., Ltd. Address 214100 No. 7, 7th Floor, Building 7, Huishan Avenue, Huishan Economic Development Zone, Wuxi City, Jiangsu Province Applicant Hangzhou Hailai Xinchuang Medical Technology Co., Ltd. (72) Inventors Ying Jianjun, Shen Qichao, Hui Jiajie, Yu Jing, Zhang Jun (51) Int.Cl. A61N 1 / 36 (2006.01) A61N 1 / 04(2006.01) G01K 13 / 00(2021.01) G01K 13 / 20(2021.01) G01N 25 / 00(2006.01) G01R 31 / 00(2006.01) H01R 13 / 70(2006.01) (54) Invention Title: Tumor Electric Field Therapy System (57) Abstract: This application provides a tumor electric field therapy system, which includes an electrode sheet and a controller. The electrode sheet includes multiple electrode units and multiple temperature detection units. The multiple temperature detection units are divided into multiple row groups and multiple column groups. The grounding terminals of each temperature detection unit in each row group are connected to the same grounding line. The signal terminals of each temperature detection unit in each column group are short-circuited with the corresponding electrode unit and then connected to the same dual-purpose signal line. The dual-purpose signal line can be connected to a DC signal or an AC signal. When the dual-purpose signal line is connected to a DC signal, each grounding line is sequentially turned on so that the temperature detection signals detected by each temperature detection unit are collected row by row. When the dual-purpose signal line is connected to an AC signal, an alternating signal is transmitted to each electrode unit. In this way, temperature detection and zone control of the electrode sheet can be performed using fewer conductive traces. Claims (3 pages), Description (46 pages), Drawings (16 pages), CN 121371480 A, 2026.01.23, CN 1 21 37 14 80 A. 1. A tumor electric field therapy system, characterized in that it comprises: an electrode sheet, which includes multiple electrode units and multiple temperature detection units, each electrode unit being capable of applying an alternating electrical signal, each temperature detection unit being respectively configured corresponding to one of the electrode units for detecting the temperature at each of the electrode units, the signal terminals of each temperature detection unit being short-circuited to the corresponding electrode unit, wherein the multiple temperature detection units are configured in the circuit as multiple row groups and multiple column groups, and the temperature detection units located in the same row group...The grounding terminals are shorted to the same grounding line, and the grounding terminals of the temperature detection units located in different row groups are connected in parallel through different grounding lines; the signal terminals of the temperature detection units located in the same column group are shorted to the same dual-purpose signal line, and the signal terminals of the temperature detection units located in different column groups are connected in parallel through different dual-purpose signal lines; the grounding line is configured to ground the grounding terminals of the temperature detection units in the corresponding row group; the dual-purpose signal line is configured to receive an AC signal to transmit an AC signal to the electrode units in the corresponding column group or to receive a DC signal to transmit a DC signal to the signal terminals of the temperature detection units in the corresponding column group; and the controller is configured to combine control of the grounding lines and the dual-purpose signal lines so that (1) when the dual-purpose signal line receives a DC signal, the grounding lines are sequentially turned on so that the temperature detection signals detected by the temperature detection units are collected row by row; (2) when the dual-purpose signal line receives an AC signal, the AC signal is transmitted to the electrode units in the corresponding column group through the dual-purpose signal line. 2. The tumor electric field therapy system according to claim 1, wherein the controller is further configured to: determine the working state of each of the electrode units according to each of the temperature detection signals; or control or adjust the intensity of the transmitted alternating electrical signal according to each of the temperature detection signals; or determine the qualification of the electrode sheet according to each of the temperature detection signals; or determine the abnormality or fault of the temperature detection unit according to each of the temperature detection signals; or identify the type of the electrode sheet according to each of the acquired temperature detection signals; or determine the over-temperature of the electrode unit according to each of the temperature detection signals; or determine the replacement of the electrode sheet according to each of the temperature detection signals. 3. The tumor electric field therapy system according to claim 1, wherein a preset temperature threshold is provided, and the controller is configured to: compare each of the temperature detection signals with the preset temperature threshold; and determine the working state of each of the electrode units or control the intensity of the alternating electrical signal transmitted to each of the electrode units according to the comparison result. 4. The tumor electric field therapy system according to claim 3, wherein the comparison result is either exceeding a preset temperature threshold or not exceeding a preset temperature threshold, the electrode unit corresponding to the temperature detection signal exceeding the preset temperature threshold is an overheating electrode unit, and the electrode unit corresponding to the temperature detection signal not exceeding the preset temperature threshold is a non-overheating electrode unit. 5. The tumor electric field therapy system according to claim 4, wherein the controller is further configured to: when at least one overheating electrode unit exists, control each of the dual-purpose signal lines to stop transmitting AC signals to each of the electrode units; or when at least one overheating electrode unit exists, control the dual-purpose signal lines electrically connected to the overheating electrode unit...The controller stops transmitting AC signals to each electrode unit in the corresponding column group, and simultaneously controls the dual-purpose signal line corresponding to the column group consisting entirely of non-overheated electrode units to continue transmitting AC signals to each electrode unit in the corresponding column group. Claims 1 / 3 page 2 CN 121371480 A 6. The tumor electric field therapy system according to claim 4, characterized in that it has a preset quantity threshold, and the controller is further configured to: determine the number of overheated columns when at least one overheated electrode unit exists; and when the number of overheated columns exceeds the preset quantity threshold, control each dual-purpose signal line to stop transmitting AC signals to all electrode units of the electrode sheet; or when the number of overheated columns does not exceed the preset quantity threshold, control the dual-purpose signal line electrically connected to the overheated electrode unit to stop transmitting AC signals to each electrode unit in the overheated column group, and control the dual-purpose signal line corresponding to the non-overheated column group to transmit AC signals to each electrode unit in the remaining columns of the electrode sheet. 7. The tumor electric field therapy system according to claim 6, wherein the intensity of the alternating current signal transmitted to each of the electrode units in the remaining columns of the electrode sheet is adjustable. 8. The tumor electric field therapy system according to claim 6, wherein the intensity of the alternating current signal transmitted to each of the electrode units in the remaining columns of the electrode sheet is respectively adjustable. 9. The tumor electric field therapy system according to claim 4, wherein a first preset temperature is less than the preset temperature threshold, and the controller is configured to: compare each of the temperature detection signals with the first preset temperature; and when all of the temperature detection signals are less than the first preset temperature, control each of the dual-purpose signal lines to transmit an alternating current signal with an increased voltage or current amplitude to each of the electrode units; or when all of the temperature detection signals are less than the preset temperature threshold and there is at least one electrode unit whose temperature detection signal exceeds the first preset temperature, control each of the dual-purpose signal lines to transmit an alternating current signal with a constant voltage or current amplitude to each of the electrode units; or when at least one of the overheated electrode units exists, control the dual-purpose signal lines to stop transmitting the alternating current signal to the electrode unit. 10. The tumor electric field therapy system according to claim 9, characterized in that stopping the transmission of AC signals to the electrode units comprises: stopping the transmission of AC signals to all the electrode units; or stopping the transmission of AC signals to each of the electrode units in the same column as the overheating electrode unit, and continuing to transmit AC signals to each of the electrode units in the remaining columns. 11. The tumor electric field therapy system according to claim 4, characterized in that it has a first preset temperature and a second preset temperature, wherein the first preset temperature is less than the second preset temperature, and the second preset temperature is less than the...A temperature threshold is set. When none of the temperature detection signals exceed the preset threshold, the controller is further configured to: compare each of the temperature detection signals with a first preset temperature; when none of the temperature detection signals exceed the first preset temperature, control each of the dual-purpose signal lines to transmit an AC signal with increased voltage or current amplitude to each of the electrode units; when at least one of the temperature detection signals exceeds the first preset temperature, compare the temperature detection signal exceeding the first preset temperature with a second preset temperature; when none of the temperature detection signals exceed the second preset temperature, control each of the dual-purpose signal lines to transmit an AC signal with unchanged voltage or current amplitude to each of the electrode units; when at least one of the temperature detection signals exceeds the second preset temperature, control each of the dual-purpose signal lines to transmit an alternating signal with decreased voltage or current amplitude to each of the electrode units. 12. The tumor electric field therapy system according to claim 4, wherein the controller is configured to: when the temperature detection signals are all much lower than the preset temperature threshold, control the dual-purpose signal line to transmit an alternating electrical signal with an increased or constant voltage or current amplitude to the electrode unit; when the temperature detection signals are close to the preset temperature threshold, control the dual-purpose signal line to transmit an alternating electrical signal with a constant or decreased voltage or current amplitude to the electrode unit. 13. The tumor electric field therapy system according to claim 1, wherein the controller is configured to: determine the region where each of the electrode units requiring an AC signal is located; and control the dual-purpose signal line corresponding to the region to transmit an AC signal to each of the electrode units requiring an AC signal. 14. The tumor electric field therapy system according to any one of claims 1-13, wherein the electrode units of each column are respectively connected to the same alternating power supply line through the corresponding dual-purpose signal line. 15. The tumor electric field therapy system according to any one of claims 1-13, characterized in that the electrode units of each column are respectively connected to different alternating power lines via corresponding dual-purpose signal lines. 16. The tumor electric field therapy system according to any one of claims 1-13, characterized in that it further includes an AC signal generator electrically connected to a controller, the controller being configured to control the intensity of the AC signal generated by the AC signal according to each of the temperature detection signals. 17. The tumor electric field therapy system according to claim 16, characterized in that it includes a power supply switch electrically connected to the AC signal generator, the controller controlling the closing and opening of the power supply switch. 18. The tumor electric field therapy system according to claim 17, characterized in that the power supply switch is a single switch; orThe power supply switches are multiple and their number is equal to the number of the columns. 19. The tumor electric field therapy system according to claim 16, characterized in that it includes multiple control switches and multiple bidirectional switching switches, each of the grounding wires is grounded through a control switch connected in series with it, and each of the dual-purpose signal lines is connected to a DC signal or an AC signal through a bidirectional switching switch connected in series with it. 20. The tumor electric field therapy system according to claim 16, characterized in that the controller is configured to: control each of the grounding wires to be disconnected when the dual-purpose signal line is connected to an AC signal; or control each of the grounding wires to be sequentially turned on in a time-sharing manner when the dual-purpose signal line is connected to a DC signal. Claims 3 / 3 Page 4 CN 121371480 A Tumor Electric Field Therapy System

[0001] This invention is a divisional application of the invention patent application filed by the applicant on October 25, 2024, with application number 202411499593.0 and invention title "Tumor Electric Field Therapy System, Electrode Sheet, Tumor Therapy Equipment and Method". Technical Field

[0002] This application relates to tumor electric field therapy technology, and more particularly to a tumor electric field therapy system. Background Art

[0003] Tumor electric field therapy is a method of treating tumors by using a low-intensity, medium-to-high frequency alternating electric field to prevent the formation of spindle microtubules during mitosis in certain tumor cells, inhibit the separation of intracellular organelles during cell division, and induce apoptosis during mitosis.

[0004] Compared with traditional cancer treatment methods, tumor electric field therapy has an innovative mechanism of action. Some physiological characteristics of tumor cells, such as their geometry and high-frequency mitosis, make them susceptible to the effects of tumor electric field therapy. Tumor electric field therapy disrupts the normal aggregation of tubulin by applying directional forces to polar particles (such as macromolecules and organelles) within the cell. These processes may lead to physical damage to the cell membrane and apoptosis. During the telophase of cell mitosis, the structural morphology of the cleavage groove leads to uneven distribution of the electric field around it. Simultaneously, under the influence of tumor electric field therapy, the electric field strength at the cleavage groove is significantly enhanced, causing charged substances in the cell to move towards the cleavage groove, interfering with or even destroying the formation of cell structures, ultimately leading to cell division failure and apoptosis.

[0005] In the related art, the tumor electric field therapy system uses an electric field application device to transmit alternating electric signals for tumor electric field therapy to electrode pads, and then applies an alternating electric field to the tumor site of the patient through the electrode pads for tumor electric field therapy. When the tumor treatment electric field is applied to the patient's body, heat will accumulate at the application site, and the temperature will rise accordingly. Therefore, it is necessary to monitor the temperature at the application site. When the temperature is too high, the electric field strength needs to be adjusted in time to reduce the risk of burns to the patient's skin due to excessive temperature.

[0006] The tumor electric field therapy system includes at least one pair of electrode pads, each electrode pad containing multiple electrode units, even...When the same alternating electrical signal is applied to each electrode unit, the heat generated on each electrode unit will vary depending on its location. This means the temperature of each electrode unit on the entire electrode sheet will not be completely uniform. Consequently, some electrode units on the entire electrode sheet may exceed the preset temperature, while others remain at a normal temperature. To improve the effectiveness of tumor electric field therapy, individual control of the overheated electrode units is required. However, for electrode sheets in related technologies, individual control of electrode units requires setting a conductive trace for each electrode unit in the electrode sheet substrate. This increases the number of conductive traces in the electrode sheet substrate, making the electrode sheet difficult to bend, and also thickens the cables electrically connected to the electrode sheet, increasing the overall weight of the electrode sheet and hindering its application.

[0007] This application aims to at least partially solve one of the technical problems in related technologies. Therefore, the first objective of this application is to propose a tumor electric field therapy system that uses fewer conductive traces to control multiple electrode units in sections, which not only improves the effectiveness of tumor electric field therapy but also facilitates electrode sheet application.

[0008] To achieve the above objectives, embodiments of this application provide a tumor electric field therapy system, comprising: an electrode sheet, which includes multiple electrode units and multiple temperature detection units. Each electrode unit can be applied with an alternating electrical signal. Each temperature detection unit is respectively configured to correspond to one of the electrode units for detecting the temperature at each electrode unit. The signal terminals of each temperature detection unit are short-circuited to the corresponding electrode unit. The multiple temperature detection units are configured in the circuit as multiple row groups and multiple column groups. The grounding terminals of each temperature detection unit in the same row group are short-circuited to the same grounding line. The grounding terminals of each temperature detection unit in different row groups are connected in parallel through different grounding lines. The signal terminals of each temperature detection unit in the same column group are short-circuited to the same dual-purpose signal line. The signal terminals of each temperature detection unit in different column groups are connected in parallel through different grounding lines. The dual-purpose signal lines of different paths are connected in parallel; the grounding line is configured to ground the grounding terminal of each temperature detection unit in the corresponding row group; the dual-purpose signal line is configured to receive an AC signal to transmit an AC signal to each electrode unit in the corresponding column group or to receive a DC signal to transmit a DC signal to the signal terminal of each temperature detection unit in the corresponding column group; and a controller is configured to combine and control each grounding line and each dual-purpose signal line so that (1) when the dual-purpose signal line is connected to a DC signal, each grounding line is sequentially turned on so that the temperature detection signal detected by each temperature detection unit is collected row by row; (2) when the dual-purpose signal line is connected to an AC signal, the signal is transmitted to each electrode unit in the corresponding column group through the dual-purpose signal line.The alternating electrical signal is transmitted.

[0009] According to the tumor electric field therapy system of this application embodiment, the multiple temperature detection units of the electrode sheet are divided into multiple row groups and multiple column groups. The grounding terminals of the temperature detection units corresponding to each electrode unit in each row group are connected to a grounding wire. The signal terminals of the temperature detection units corresponding to each electrode unit in each column group are short-circuited with the corresponding electrode unit and then connected to the same dual-purpose signal line. At the same time, the controller controls the dual-purpose signal line to be connected to a DC signal or an AC signal. When the dual-purpose signal line is connected to a DC signal, each grounding wire is sequentially turned on so that the temperature detection signals detected by each temperature detection unit are collected row by row. When the dual-purpose signal line is connected to an AC signal, an alternating electrical signal is transmitted to each electrode unit through the dual-purpose signal line. In this way, temperature sampling and alternating electrical signal application can be realized through the dual-purpose signal line. Not only is a new AC signal line (i.e., AC line) not added, but the original AC signal line is also eliminated. Thus, multiple electrode units can be controlled by partition using fewer conductive traces. This not only improves the effect of tumor electric field therapy, but also facilitates the application of electrode sheets.

[0010] The above description is only an overview of the technical solution of this application. In order to better understand the technical means of this application and to implement it in accordance with the contents of the specification, and in order to make the above and other objects, features and advantages of this application more obvious and understandable, the following are specific embodiments of this application.

[0011] FIG1 is a schematic diagram of a tumor electric field therapy system according to an embodiment of the present application;

[0012] FIG2 is a schematic diagram of the structure of the electrode sheet of the tumor electric field therapy system shown in FIG1;

[0013] FIG3 is a schematic diagram of the circuit connection between an electrode sheet and an adapter of the tumor electric field therapy system shown in FIG1;

[0014] FIG4 is similar to FIG3, but is another schematic diagram of the circuit connection between an electrode sheet and an adapter shown in FIG3;

[0015] FIG5 is a schematic diagram of the circuit connection between an electrode sheet, an adapter, and an electric field generator of the tumor electric field therapy system shown in FIG1;

[0016] FIG6 is a schematic block diagram of the internal structure of the adapter of the tumor electric field therapy system shown in FIG1;

[0017] FIG7 is a schematic block diagram of the internal structure of the electric field generator of the tumor electric field therapy system shown in FIG1;

[0018] FIG8 is a flowchart of an electrode sheet temperature detection method according to an embodiment of the present application;

[0019] FIG9 is a flowchart of an electrode sheet abnormality detection method according to an embodiment of the present application; Specification 2 / 46 pages 6 CN 121371480 A

[0020] Figure 10 is a flowchart illustrating a control method for a tumor electric field therapy system according to an embodiment of this application;

[0021] Figure 11 is a flowchart illustrating an electrode type identification method according to an embodiment of this application;

[0022] Figure 12 is a flowchart illustrating a signal control method for tumor electric field therapy according to an embodiment of this application;

[0023] Figure 13 is a flowchart illustrating an electrode temperature detection method according to another embodiment of this application;

[0024] Figure 14 is a flowchart illustrating an alternating current signal application method for tumor electric field therapy according to another embodiment of this application;

[0025] Figure 15 is a flowchart illustrating an alternating current signal application method based on temperature detection signal according to an embodiment of this application;

[0026] Figure 16 is a flowchart illustrating an alternating current signal application method based on temperature detection signal according to another embodiment of this application.

[0027] FIG17 is a schematic diagram of a tumor electric field therapy system according to another embodiment of the present application;

[0028] FIG18 is a schematic diagram of the circuit connection between an electrode plate, an adapter, and an electric field generator in a tumor electric field therapy system according to another embodiment of the present application;

[0029] FIG19 is a schematic block diagram of the internal structure of the adapter of the tumor electric field therapy system shown in FIG18;

[0030] FIG20 is a schematic block diagram of the internal structure of the electric field generator of the tumor electric field therapy system shown in FIG18;

[0031] FIG21 is a flowchart of a control method for a tumor electric field therapy system according to another embodiment of the present application;

[0032] FIG22 is a flowchart of a signal control method for tumor electric field therapy according to another embodiment of the present application;

[0033] Explanation of reference numerals:

[0034] Tumor electric field therapy system 100 or 100', electrode pads 13 or 13', first cable 15 or 15', adapter 20 or 20', second cable 25 or 25', electric field generator 30 or 30', substrate 31 or 31', electrode unit 33 or 33', temperature detection unit 35 or 35', grounding terminal 35-1 or 35-1', signal terminal 35-2 or 35-2', temperature sensor 34 or 34', grounding terminal 34- 1 or 34-1', signal terminal 34-2 or 34-2', electrode unit 33 or 33', diode 36 or 36', anode 36-1 or 36-1', cathode 36-2 or 36-2', second power module 32 or 32', second controller 37 or 37', second communication unit 38 or 38', AC signal generator 39 or 39', power supply switch 40 or 40', first controller 51 or 51', ADC unit 52 or 52', voltage divider resistor 53 or 53', control switch 54 or 54', first control switch 5 4-1 or 54-1', second control switch 54-2 or 54-2', third control switch 54-3 or 54-3', fourth control switch 54-4 or 54-4', bidirectional switch 55 or 55', first bidirectional switch 55-1 or 55-1', second bidirectional switch 55-2 or 55-2', third bidirectional switch 55-3 or 55-3', fourth bidirectional switch 55-4 or 55-4', fifth bidirectional switch 55-5 or 55-5', first communication unit 56 or 56', alternating power supplyLine 57 or 57', first power module 58 or 58', grounding wire 18 or 18', first grounding wire 18-1 or 18-1', second grounding wire 18-2 or 18-2', third grounding wire 18-3 or 18-3', fourth grounding wire 18-4 or 18-4', dual-purpose signal line 19 or 19', first dual-purpose signal line 19-1 or 19-1', second dual-purpose signal line 19-2 or 19-2', third dual-purpose signal line 19-3 or 19-3', fourth dual-purpose signal line 19-4 or 19-4', fifth dual-purpose signal line 19-5 or 19-5', first connector 60 or 60', first plug 61, first socket 62, second connector 70 or 70', second plug 71 or 71', second socket 72 or 72'. Detailed Embodiments

[0035] The embodiments of the technical solution of this application will be described in detail below with reference to the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solutions of this application, and are therefore only examples, and cannot be used to limit the scope of protection of this application.

[0036] Embodiment 1:

[0037] FIG1 shows a schematic diagram of a tumor electric field therapy system 100 according to an embodiment of this application. As shown in FIG1, the tumor electric field therapy system 100 includes: at least one pair of electrode plates 13, an adapter 20 connected to the at least one pair of electrode plates 13, and an electric field generator 30 connected to the adapter 20. The at least one pair of electrode plates 13 can be arranged in pairs on the patient's body surface, as shown in FIG1 with four electrode plates 13, each pair of electrode plates 13 being arranged on the patient's body surface. The electric field generator 30 is used to supply power to the at least one pair of electrode plates 13, so that the at least one pair of electrode plates 13 generates an alternating electric field for treating tumors. The adapter 20 is electrically connected between at least one pair of electrode pads 13 and the electric field generator 30, and is used to transmit the alternating electric signal generated by the electric field generator 30 to at least one pair of electrode pads 13. That is, the electric field generator 30 can generate an alternating electric signal, and the generated alternating electric signal is transmitted to each electrode pad 13 through the adapter 20, so that an alternating electric field for tumor treatment is generated between the same pair of electrode pads 13, so as to apply the alternating electric field to the tumor site of the patient for tumor treatment.

[0038] As shown in FIG1, in this embodiment, there are 4 electrode pads 13, each electrode pad 13 includes the same number of electrode units 33, each electrode unit 33 is electrically connected to the adapter 20, and there are 20 electrode units 33 on each electrode pad 13. In other embodiments, the tumor electric field therapy system 100 may have more or fewer electrode pads 13; in other embodiments, each pair of electrode pads 13 has the same number of electrode units 33, and different pairs of electrode pads 13 may have different numbers of electrode units 33; in other embodiments, the number of electrode units 33 on each electrode pad 13 is...The number can be 9, 13, etc.

[0039] Figures 3 and 4 are schematic diagrams of the circuit connection between the electrode sheet 13 and the adapter 20 in two working states of the tumor electric field therapy system 100 shown in Figure 1. It is worth noting that the arrangement of the electrode units 33 shown in Figures 3 and 4 is to more clearly show the electrical connection between an electrode sheet 13 and the adapter 20. The arrangement of the electrode units 33 shown in Figures 3 and 4 does not represent the spatial arrangement of the electrode units 33. Combining Figures 1, 3 and 4, the electrode sheet 13 includes: a substrate 31, a plurality of electrode units 33 electrically connected to the substrate 31 at intervals, a plurality of temperature detection units 35, and a first cable 15 electrically connected to the substrate 31. The substrate 31 can be a flexible circuit board. The substrate 31 is embedded with multiple conductive traces, including multiple ground lines 18 and multiple dual-purpose signal lines 19. The first cable 15 has multi-core wires (not shown), each of which is electrically connected to the multiple grounding wires 18 and the multiple dual-purpose signal lines 19 of the substrate 31. In this embodiment, the total number of grounding wires 18 and dual-purpose signal lines 19 embedded in the substrate 31 does not exceed 10, so the number of wires in the first cable 15 does not exceed 10.

[0040] Multiple electrode units 33 are configured into multiple row groups and multiple column groups. In this embodiment, each electrode sheet 13 is provided with 20 electrode units 33. The 20 electrode units 33 are arranged in the order of 1 to 20 in the circuit connection and are divided into four row groups and five column groups, that is, the 20 electrode units 33 are arranged in four rows and five columns in the circuit connection. Each electrode unit 33 corresponds to a temperature detection unit 35, and each temperature detection unit 35 has a signal terminal 35-2 and a ground terminal 35-1. Both electrode unit 33 and temperature detection unit 35 are soldered onto substrate 31. The signal terminals 35-2 of electrode unit 33 and corresponding temperature detection unit 35 are short-circuited. Since multiple temperature detection units 35 are configured one-to-one with multiple electrode units 33, the multiple temperature detection units 35 are arranged in a four-row, five-column configuration in their circuit connections. It should be noted that this arrangement is for clearer illustration of the electrical connection between electrode sheet 13 and adapter 20, and does not represent the spatial arrangement of electrode units 33. Their spatial structure may be a roughly array-like structure as shown in Figure 2, or other structures such as petal-shaped or scattering structures; they can be regular or irregular. Electrode unit 33 is configured to apply an alternating electric field to the patient's tumor site. Temperature detection unit 35 is configured to detect the temperature of the patient's body surface where the electrode sheet 13 is attached, i.e., the temperature at the corresponding electrode unit 33, and output a temperature detection signal to adapter 20. In this embodiment, the multiplexed signal lines 19 of the substrate 31 are respectively arranged in a one-to-one correspondence with the multiple columns of the electrode units 33, and are configured to generate an electric field.The alternating electrical signal generated by the device 30 is transmitted to each electrode unit 33 in the corresponding column group. That is, the electrode units 33 located in the same column group are all shorted through the same dual-purpose signal line 19 of the substrate 31, and the electrode units 33 located in different columns are connected in parallel through different dual-purpose signal lines 19 of the substrate 31. The dual-purpose signal line 19 of the substrate 31 is electrically connected to the first cable 15, and then electrically connected to the electric field generator 30 through the adapter 20. Further, the dual-purpose signal line 19 of the substrate 31 receives the alternating electrical signal generated by the electric field generator 30 through the first cable 15 and the adapter 20.

[0041] The electrode pads 13 have three working modes. In the first mode, an alternating electrical signal is applied through the electrode unit 33; in the second mode, the temperature of the patient's body surface to which the corresponding electrode unit 33 is applied is detected or collected by the temperature detection unit 35; in the third mode, the application of the alternating electrical signal is stopped and the temperature detection and collection are stopped. The first mode, the second mode, and the third mode do not overlap in time periods. That is, the time period during which the electrode unit 33 applies an AC signal is staggered and does not overlap with the time period during which the temperature detection unit 35 detects the temperature. The electrode sheet 13 can cycle between applying an AC signal through its electrode unit 33 and detecting the temperature through its temperature detection unit 35, that is, the electrode sheet 13 cycles between the first mode and the second mode. The electrode sheet 13 can also cycle between the first mode, the second mode, and the third mode, that is, the electrode sheet 13 cycles between applying an AC signal through the electrode unit 33, collecting or detecting the temperature through the temperature detection unit 35, stopping the application of the AC signal, and collecting the temperature.

[0042] The multiple grounding wires 18 are respectively set one-to-one with the multiple rows of the electrode unit 33, and the multiple grounding wires 18 are respectively used to short-circuit and ground each temperature detection unit 35 corresponding to each row group in sequence. That is, the grounding terminals 35-1 of multiple temperature detection units 35 located in the same row group are all shorted through the same grounding line 18 of the substrate 31, and the grounding terminals 35-1 of temperature detection units 35 located in different row groups are connected in parallel through different grounding lines 18 of the substrate 31. During the temperature detection period, only one of the multiple grounding lines 18 is conducting at any given time, and the other three are disconnected.

[0043] Each of the multiple dual-purpose signal lines 19 is also configured to short-circuit the signal terminal 35-2 of at most one temperature detection unit 35 in each row group to an external device for receiving detection signals. The signal terminals 35-2 of the temperature detection units 35 connected to each of the multiple dual-purpose signal lines 19 are different to avoid the dual-purpose signal lines 19 from outputting duplicate signals later. That is, when the number of electrode units 33 in a row group is the same as the number of dual-purpose signal lines 19, each dual-purpose signal line 19 is divided intoEach temperature detection unit 35 in a row group is electrically connected to its signal terminal 35-2. When the number of electrode units 33 in a row group is less than the number of dual-purpose signal lines 19, at least one dual-purpose signal line 19 is not electrically connected to the signal terminal 35-2 of the temperature detection unit 35, and the remaining dual-purpose signal lines 19 are electrically connected to the signal terminal 35-2 of each temperature detection unit 35 in the row group. In this embodiment, the external device for receiving the detection signal is an adapter 20. The signal terminals 35-2 of multiple temperature detection units 35 located in different columns are connected in parallel through different dual-purpose signal lines 19 of the substrate 31, and the signal terminals 35-2 of multiple temperature detection units 35 located in the same column group are all short-circuited to the same dual-purpose signal line 19 of the substrate 31.

[0044] In this embodiment, with each electrode unit 33 equipped with a temperature detection unit 35 for temperature detection, the above-mentioned circuit design reduces the number of wires in the first cable 15, avoiding the cable becoming thicker and harder, thus increasing the difficulty of cable fixation; at the same time, it avoids the increased number of wires in the first cable 15 affecting the adhesion effect between the electrode sheet 13 and the corresponding body surface of the patient's tumor site. The base plate 31 has a total of 9 lines for the grounding wire 18 and the dual-purpose signal line 19. Specifically, in this embodiment, the base plate 31 has 4 lines for the grounding wire 18 and 5 lines for the dual-purpose signal line 19. The number of grounding wires 18 is related to the number of rows M of the electrode unit 33, which is greater than or equal to the number of rows M of the electrode unit 33, where M is a positive integer. The number of dual-purpose signal lines 19 is related to the number of columns N of the electrode unit 33, which is greater than or equal to the number of columns N of the electrode unit 33, where N is a positive integer. The number of lines L embedded in the substrate 31 of the electrode sheet 13 is equal to the sum of the number of grounding lines 18 and the number of dual-purpose signal lines 19. In this embodiment, the number of grounding lines 18 is equal to the number of rows M of the electrode unit 33; the number of columns N of the dual-purpose signal lines 19 is equal to the number of columns N of the electrode unit 33.

[0045] Multiple electrode units 33 are arranged in a roughly two-dimensional array on the substrate 31. As shown in FIG2, the electrode sheet 13 in this embodiment (page 5 / 46, CN 121371480 A) includes 20 electrode units 33 and 20 temperature detection units 35 corresponding to the electrode units 33. The 20 electrode units 33 are arranged in a four-row, six-column array. The first and fourth rows each have four electrode units 33, and the second and third rows each have six electrode units 33. The four electrode units 33 in each of the first and fourth rows are located in the columns from the second to the fifth, and the six electrode units 33 in each of the second and third rows are located in the columns from the first to the sixth. Divide the four electrode units 33 in the first row into region 1, and divide the region into the first column of the second row and the first column of the third row.The electrode units 33 in the second and third columns of the fourth row are divided into region 2, the electrode units 33 in the sixth column of the second row, the sixth column of the third row, and the fourth and fifth columns of the fourth row are divided into region 3, the electrode units 33 in the second and third columns of the second row and the second and third columns of the third row are divided into region 4, and the electrode units 33 in the fourth and fifth columns of the second row and the fourth and fifth columns of the third row are divided into region 5. Each region (1-5) corresponds to a column group. In some other embodiments, the 20 electrode units 33 may also be arranged in other ways. Of course, in some other embodiments, the electrode sheet 13 may also have other numbers of electrode units 33. In summary, the implementation of this application is not limited by the number and arrangement of the electrode units 33 of the electrode sheet 13.

[0046] Each electrode unit 33 can be applied with an alternating electrical signal, thereby the paired electrode sheets 13 are used to apply an alternating electric field to the tumor site of the patient. Optionally, the electrode unit 33 is a dielectric element, such as a ceramic sheet, or a polymer dielectric layer made of polymer material. Each temperature detection unit 35 is provided corresponding to one electrode unit 33 to detect the temperature at the corresponding electrode unit 33. Each temperature detection unit 35 can be located at any position of the corresponding electrode unit 33. In this embodiment, each electrode unit 33 is provided with a through hole 331, which is suitable for installing the temperature detection unit 35. For example, each electrode unit 33 has a through hole 331 in the middle, and each electrode unit 33 has a corresponding temperature detection unit 35 housed in the through hole 331. Each temperature detection unit 35 includes a temperature sensor 34 and a diode 36. The temperature sensor 34 has a signal terminal 34-2 and a ground terminal 34-1. The diode 36 has an anode 36-1 and a cathode 36-2. The anode 36-1 of the diode 36 is connected to the ground terminal 34-1 of the temperature sensor 34. The cathode 36-2 of the diode 36 serves as the ground terminal 35-1 of the temperature detection unit 35. The signal terminal 34-2 of the temperature sensor 34 serves as the signal terminal 35-2 of the temperature detection unit 35. The temperature sensor 34 can be a thermistor or other temperature sensors besides thermistors. Each temperature sensor 34 corresponds to a diode 36. The diode 36 is connected in series with the corresponding temperature sensor 34, which can prevent the reverse flow of current to prevent the detection signal from other electrode units 33 from affecting the temperature sensor 34.

[0047] As shown in FIG3 or FIG4, the electrode sheet 13 of this embodiment includes four grounding wires 18. Each grounding wire 18 is used to ground the ground terminals 35-1 of the temperature detection units 35 in the same row group. The four grounding wires 18 of the electrode plate 13 are designated as the first grounding wire 18-1, the second grounding wire 18-2, the third grounding wire 18-3, and the fourth grounding wire 18-4. In the four rows of the electrode plate 13,The first row group consists of electrode units 33-1 to 33-5, the second row group consists of electrode units 33-6 to 33-10, the third row group consists of electrode units 33-11 to 33-15, and the fourth row group consists of electrode units 33-16 to 33-20. Specifically, the first grounding wire 18-1 is used to ground electrode units 33-1 to 33-5 in the first row group; the second grounding wire 18-2 is used to ground electrode units 33-6 to 33-10 in the second row group; the third grounding wire 18-3 is used to ground electrode units 33-11 to 33-15 in the third row group; and the fourth grounding wire 18-4 is used to ground electrode units 33-16 to 33-20 in the fourth row group. It should be noted that these grounding wires 18 can be selectively closed or opened. This can be achieved by connecting each grounding wire 18 in series with a control switch 54. That is, the grounding terminals 35-1 of the temperature detection units 35 corresponding to each electrode unit 33 in each row group are connected to the grounding pin through a control switch 54, which will be described in detail below. The above-mentioned "grounding the electrode unit 33" can refer to grounding the grounding terminal 34-1 of the temperature sensor 34 corresponding to each electrode unit 33, or it can refer to the diode 36 being connected in series with the corresponding temperature sensor 34 and grounded together. In short, each grounding wire 18 short-circuits and grounds the grounding terminals 35-1 of all the temperature detection units 35 corresponding to all the electrode units 33 in each row group.

[0048] As shown in FIG3 or FIG4, the electrode sheet 13 of this embodiment further includes five dual-purpose signal lines 19. One end of each dual-purpose signal line 19 is connected to the signal terminal 35-2 of all electrode units 33 in each column group and the temperature detection unit 35 corresponding to each electrode unit 33, and the other end is connected to the adapter 20 for receiving temperature detection signals and transmitting alternating electrical signals. That is, for each row group, each dual-purpose signal line 19 can be selectively connected to one of the electrode units 33 or not connected to any of the electrode units 33 in the row group to avoid the dual-purpose signal line 19 outputting repeated signals in the future. Specifically, the five dual-purpose signal lines 19 of the electrode sheet 13 include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the signal terminals 35-2 of four electrode units 33 (electrode unit 33-1, electrode unit 33-6, electrode unit 33-11, and electrode unit 33-16) and their corresponding temperature detection units 35; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the electrode...The signal terminals 35-2 of four electrode units 33 (unit 33-2, electrode unit 33-7, electrode unit 33-12, and electrode unit 33-17) and their respective temperature detection units 35 are connected simultaneously. One end of the third dual-purpose signal line 19-3 is connected to the signal terminals 35-2 of four electrode units 33 (unit 33-3, electrode unit 33-8, electrode unit 33-13, and electrode unit 33-18) and their respective temperature detection units 35. One end of the fourth dual-purpose signal line 19-4 is connected to the signal terminals 35-2 of four electrode units 33 (unit 33-4, electrode unit 33-9, electrode unit 33-14, and electrode unit 33-19) and their respective temperature detection units 35. One end of the fifth dual-purpose signal line 19-5 is connected to the signal terminals 35-2 of four electrode units 33 (unit 33-5, electrode unit 33-10, electrode unit 33-15, and electrode unit 33-20) and their respective temperature detection units 35. In short, each dual-purpose signal line 19 short-circuit the signal terminals 35-2 of each electrode unit 33 and its corresponding temperature detection unit 35 located in the same column group, and uses them to connect to external devices. It should be noted that these dual-purpose signal lines 19 can selectively transmit alternating electrical signals or receive temperature detection signals, which can be achieved by connecting each dual-purpose signal line 19 in series with a bidirectional switching switch 55 and coordinating the closing or opening of the grounding wire 18. That is, after the signal terminals 35-2 of each temperature detection unit 35 in each column group are shorted to the corresponding electrode unit 33, they are connected to the switching unit (unlabeled) through a dual-purpose signal line 19. The switching unit (unlabeled) includes multiple bidirectional switching switches 55, which are configured to switch the dual-purpose signal line 19 to the temperature sampling point (unlabeled) or the alternating power line 57. When the dual-purpose signal line 19 is connected to the temperature sampling point (unlabeled), the switching state of the control switch 54 is configured so that the temperature detection signal detected by the corresponding temperature detection unit 35 in each row group is sampled based on the temperature sampling point (unlabeled), and when the dual-purpose signal line 19 is connected to the alternating power line 57, at least one column group's electrode unit 33 is applied with an alternating electrical signal based on the alternating power line 57. This will be described in detail below.

[0049] The multiple grounding lines 18 and the multiple dual-purpose signal lines 19 are both conductive traces embedded in the substrate 31. The substrate 31 is electrically connected to the first cable 15. The multiple grounding wires 18 and multiple dual-purpose signal lines 19 embedded in the substrate 31 are electrically connected to the corresponding wires (not shown) in the first cable 15.

[0050] The tumor electric field therapy system 100 of this embodiment includes at least one pair of the above-mentioned electrode plates 13, an adapter 20 electrically connected to the electrode plates 13, and an electric field generator 30 electrically connected to the adapter 20. The adapter 20 is connected to the electrode plates 13 and the electric field generator 30.Between the electric field generators 30. The electric field generator 30 provides alternating electrical signals to multiple electrode units 33 of the electrode plate 13 via the adapter 20 and the dual-purpose signal line 19 of the electrode plate 13, or is used to receive temperature detection signals output by the temperature detection units 35 corresponding to the multiple electrode units 33. The adapter 20 transmits the alternating electrical signals generated by the electric field generator 30 to the dual-purpose signal line 19 of the electrode plate 13, and is also configured to receive temperature detection signals output by the multiple dual-purpose signal lines 19 of the electrode plate 13.

[0051] Referring to Figures 3 and 4, the adapter 20 includes: a first controller 51, multiple sets of ADC units 52 connected to the first controller 51, multiple sets of voltage-reducing resistors 53 and multiple sets of control switches 54 corresponding to the multiple sets of ADC units 52, multiple sets of bidirectional switching switches 55 corresponding to the multiple sets of ADC units 52, a first communication unit 56, an alternating power line 57 corresponding to each set of bidirectional switching switches 55, and a first power module 58 connected to the first communication unit 56, the first controller 51, and the multiple sets of ADC units 52. The first power module 58 provides DC power VCC to each electronic component of the adapter 20. The adapter 20 also includes multiple circuit lines (unlabeled), which are electrically connected to the multiple grounding lines 18 and multiple dual-purpose signal lines 19 in the substrate 31 of the corresponding electrode 13 via the first cable 15 of the corresponding electrode 13. The multiple circuit lines (unlabeled) include multiple alternating power lines 57 that transmit alternating electrical signals to the corresponding electrode 13 and are electrically connected to the multiple dual-purpose signal lines 19 in the substrate 31 of the corresponding electrode 13; multiple circuit lines (unlabeled) that are electrically connected to the multiple dual-purpose signal lines 19 in the substrate 31 of the corresponding electrode 13 and are used to power the temperature detection units 35 of the electrode 13 or transmit the temperature detection signals of the electrode 13; and multiple circuit lines (unlabeled) that are electrically connected to the multiple grounding lines 18 in the substrate 31 of the corresponding electrode 13. The number L of circuit lines electrically connecting the adapter 20 to one electrode piece 13 is equal to the sum of the number of rows and columns of the electrode units 33 of the electrode piece 13; the number H of circuit lines electrically connecting the adapter 20 to X electrode pieces 13 is equal to X times the number of circuit lines electrically connecting it to a single electrode piece 13, that is, H=XL=X×(M+N). The number of groups of control switches 54 and the number of groups of bidirectional switching switches 55 are related to the number of electrode pieces 13. The number of groups of control switches 54 is the same as the number of groups of bidirectional switching switches 55, and is not less than the number of electrode pieces 13. Optionally, the number of groups of control switches 54 and bidirectional switching switches 55 is the same as the number of electrode pieces 13. The following is a detailed description of the electrical connection between an electrode piece 13 with 20 electrode units 33 and the adapter 20.

[0052] Each group of control switches 54 has multiple control switches 54, which are respectively connected to the adapter 20 and electrically connected to the circuit lines (unlabeled) corresponding to the multiple grounding wires 18 of a corresponding electrode piece 13, and are configured to control the conduction or disconnection of the multiple grounding wires 18. The circuit lines (unlabeled) that are electrically connected to the multiple grounding wires 18 of the electrode piece 13 are grounded at the end near the control switch 54. The number of control switches 54 in each group of control switches 54 is related to the number of grounding wires 18 of the substrate 31 of the corresponding electrode piece 13, and in this embodiment, the two are equal. As shown in Figure 3 or Figure 4, in this embodiment, the multiple control switches 54 are respectively the first control switch 54-1, the second control switch 54-2, the third control switch 54-3, and the fourth control switch 54-4. The multiple control switches 54 in the same group control the closing or opening of the corresponding grounding wire 18 of the same electrode piece 13. The first control switch 54-1 is used to control the opening or closing of the first grounding wire 18-1 of the corresponding electrode plate 13, and can cooperate with the corresponding set of bidirectional switching switches 55 to control the energization and de-energization of the temperature detection units 35 corresponding to the five electrode units 33 from electrode unit 33-1 to electrode unit 33-5 in the first row group 33 of the electrode plate 13; the second control switch 54-2 is used to control the opening or closing of the second grounding wire 18-2 of the electrode plate 13, and can cooperate with the corresponding set of bidirectional switching switches 55 to control the energization and de-energization of the temperature detection units 35 corresponding to the five electrode units 33 from electrode unit 33-6 to electrode unit 33-10 in the second row group 33 of the electrode plate 13; the third control switch 54-3 is used to control the opening or closing of the third grounding wire 18-3 of the electrode plate 13, and can cooperate with the corresponding set of bidirectional switching switches 55 to control the energization and de-energization of the electrode plate 13. The electrode plate 13 is in the third row group 33, where the electrode units 33-11 to 33-15 correspond to the temperature detection units 35. The fourth control switch 54-4 is used to control the opening or closing of the fourth grounding wire 18-4 of the electrode plate 13, and can cooperate with the corresponding bidirectional switching switch 55 to control the opening and closing of the temperature detection units 35 corresponding to the electrode units 33-16 to 33-20 in the fourth row group 33 of the electrode plate 13. The control switch 54 can be a mechanical switch, such as a relay. The control switch 54 can also be an electronic switch, and each control switch 54 can be opened and closed by an additional first controller 51.

[0053] In this embodiment, multiple sets of control switches 54 are all electronic switches. The first controller 51 is communicatively connected to multiple sets of control switches 54, and is used to sequentially and cyclically control the opening and closing states of multiple control switches 54 in each set of control switches 54, thereby sequentially and individually energizing each of the multiple grounding wires 18 in the corresponding electrode plate 13 and cooperating with the corresponding bidirectional switching switch 55.The switching of CN 121371480 A on page 8 / 46 of the manual is used to collect the temperature of the patient's body surface detected by all temperature detection units 35 on the electrode pad 13. The number of control switches 54 in each group is not less than the number of grounding wires 18 of the substrate 31 of the corresponding electrode pad 13. In this embodiment, the number of control switches 54 in each group is the same as the number of grounding wires 18 of the corresponding electrode pad 13.

[0054] Each group of bidirectional switching switches 55 is provided with multiple bidirectional switching switches 55. The multiple bidirectional switching switches 55 in each group are respectively connected to the adapter 20 and electrically connected to the circuit lines (unlabeled) corresponding one-to-one with the multi-channel dual-purpose signal lines 19 of the corresponding electrode pad 13. The number of bidirectional switching switches 55 in each group of bidirectional switching switches 55 is related to the number of dual-purpose signal lines 19 of the substrate 31 of the corresponding electrode pad 13, which is greater than or equal to the number of dual-purpose signal lines 19 of the substrate 31 of the corresponding electrode pad 13. In this embodiment, the two are equal. Each bidirectional switch 55 has a signal acquisition terminal 1 labeled 1 and a signal input terminal 2 labeled 2. The signal acquisition terminals 1 of multiple bidirectional switches 55 in the same group are electrically connected to the corresponding detection channels of multiple detection channels of a group of ADC units 52 through temperature sampling points (unlabeled). The signal input terminals 2 of each bidirectional switch 55 in the same group are electrically connected to the same AC power line 57 and are configured to control the multi-purpose signal line 19 to connect to the corresponding AC power line 57 to transmit AC electrical signals or to the corresponding detection channel of the corresponding group of ADC units 52 to receive the temperature detection signal output by the temperature detection unit 35.

[0055] As shown in FIG3 or FIG4, taking the electrical connection of an electrode plate 13 with the adapter 20 as an example, in this embodiment with 20 electrode units 33, the multiple bidirectional switches 55 are respectively the first bidirectional switch 55-1, the second bidirectional switch 55-2, the third bidirectional switch 55-3, the fourth bidirectional switch 55-4 and the fifth bidirectional switch 55-5. Multiple bidirectional switching switches 55 in the same group control the switching of a corresponding dual-purpose signal line 19 of the same electrode plate 13 between transmitting alternating electrical signals and transmitting temperature detection signals. Specifically, the first bidirectional switching switch 55-1 is used to control the switching of the first dual-purpose signal line 19-1 of the corresponding electrode plate 13 between transmitting alternating electrical signals and transmitting temperature detection signals, thereby controlling the switching between the conduction of each electrode unit 33 of the electrode units 33-1, 33-6, 33-11, and 33-16 in the first column of the electrode plate 13 and the conduction of the signal terminal 35-2 of each temperature detection unit 35 corresponding to the electrode units 33-1, 33-6, 33-11, and 33-16 in the first column of the electrode plate 13.In conjunction with corresponding control switches 54-1, 54-2, 54-3, and 54-4, the first row of electrode units 33-1, 33-6, 33-11, and 33-16 transmit alternating electrical signals to the patient or output temperature detection signals collected by the temperature detection units 35 corresponding to these electrode units 33 to the corresponding ADC unit 52; the second bidirectional switching switch 55-2 is used to control the switching of the second dual-purpose signal line 19-2 of the corresponding electrode sheet 13 between transmitting alternating electrical signals and transmitting temperature detection signals, thereby controlling the conduction of each electrode unit 33 of the second row of electrode units 33-2, 33-7, 33-12, and 33-17 in the electrode sheet 13 and the signal terminals 35-2 of each temperature detection unit 35 corresponding to the electrode units 33-2, 33-7, 33-12, and 33-17 in the second row of electrode units 33-2, 33-7, 33-12, and 33-17 in the electrode sheet 13. The switching between the two is activated and connected to the corresponding control switches 54-1, 54-2, 54-3, and 54-4. The second row of electrode units 33-2, 33-7, 33-12, and 33-17 are coordinated to transmit alternating electrical signals to the patient or output temperature detection signals collected by the temperature detection units 35 corresponding to these electrode units 33 to the corresponding ADC unit 52. A third bidirectional switch 55-3 controls the switching of the third dual-purpose signal line 19-3 of the corresponding electrode pad 13 between transmitting alternating electrical signals and transmitting temperature detection signals. This controls the switching between the conduction of each electrode unit 33 in the third row of electrode units 33-3, 33-8, 33-13, and 33-18 and the conduction of the signal terminals 35-2 of the corresponding temperature detection units in the third row of electrode units 33-3, 33-8, 33-13, and 33-18, and the switching between these two states, and the corresponding control switches 54-1, 54-2, and 54-3. Control switch 54-4 is used to enable the third column of electrode units 33-3, 33-8, 33-13, and 33-18 to transmit alternating electrical signals to the patient or output temperature detection signals collected by the corresponding electrode units 33 to the corresponding ADC unit 52; the fourth bidirectional switching switch 55-4 is used to control the switching of the fourth dual-purpose signal line 19-4 of the corresponding electrode 13 between transmitting alternating electrical signals and transmitting temperature detection signals, thereby controlling the conduction of each electrode unit 33 in the fourth column of the electrode 13, namely electrode units 33-4, 33-9, 33-14, and 33-19.The signal terminals 35-2 of each temperature detection unit 35 corresponding to electrode units 33-4, 33-9, 33-14, and 33-19 in the fourth column are switched and cooperate with the corresponding control switches 54-1, 54-2, 54-3, and 54-4 to enable the fourth column of electrode units 33-4, 33-9, 33-14, and 33-19 to transmit alternating electrical signals to the patient or output temperature detection signals collected by the temperature detection units 35 corresponding to these electrode units 33 to the corresponding ADC unit 52; the fifth bidirectional switching switch 55-5 is used to control the corresponding electrode pads 13. The fifth dual-purpose signal line 19-5 switches between transmitting alternating electrical signals and transmitting temperature detection signals, thereby controlling the conduction of each electrode unit 33 in the fifth column group of electrode units 33-5, 33-10, 33-15, and 33-20, and the conduction of the signal terminals 35-2 of the corresponding temperature detection units 35 in the fifth column group of electrode units 33-5, 33-10, 33-15, and 33-20. The switching between the two is coordinated with the corresponding control switches 54-1, 54-2, 54-3, and 54-4, so that the fifth column of electrode units 33-5, 33-10, 33-15, and 33-20 transmits alternating electrical signals to the patient or outputs temperature detection signals collected by the temperature detection units 35 corresponding to these electrode units 33 to the corresponding ADC unit 52. When the signal input terminal 2 of each set of bidirectional switching switches 55 is turned on and the signal acquisition terminal 1 is turned off, alternating electrical signals can be transmitted to each electrode unit 33 of the corresponding electrode plate 13. When the signal acquisition terminal 1 of each set of bidirectional switching switches 55 is turned on and the signal input terminal 2 is turned off, it can cooperate with each control switch 54 in the corresponding set of control switches 54 to transmit the temperature detection signals collected by each temperature detection unit 35 on the electrode plate 13 in a time-division manner. The bidirectional switching switch 55 can be a mechanical switch, such as a relay. The bidirectional switching switch 55 can also be an electronic switch, and each bidirectional switching switch 55 can be switched by an additional first controller 51.

[0056] In this embodiment, all sets of bidirectional switching switches 55 are electronic switches. The first controller 51 is communicatively connected to multiple sets of bidirectional switching switches 55, and is used to control the switching of multiple bidirectional switching switches 55 in each set between their respective signal acquisition terminal 1 and signal input terminal 2, and cooperate with the closing or opening of the corresponding control switch 54 to continuously monitor the temperature of the patient's body surface detected by all temperature detection units 35 on the electrode pad 13 or transmit alternating electrical signals to the patient.

[0057] In this embodiment, each ADC unit 52 is connected to the corresponding ADC unit 52 through multiple circuit lines (unlabeled) in the adapter 20.The signal acquisition terminals 1 of the multiple bidirectional switching switches 55 in the group are electrically connected one-to-one and configured to receive the temperature detection signals transmitted by the multi-purpose signal lines 19 of the corresponding electrode plates 13, and convert the temperature detection signals from analog signals to digital signals. Each ADC unit 52 includes multiple detection channels A, B, C, D, and E. Each detection channel A, B, C, D, and E is used to connect to one of the corresponding multi-purpose signal lines 19 through the corresponding bidirectional switching switch 55. As shown in Figure 3 or Figure 4, each ADC unit 52 contains a total of 5 detection channels A, B, C, D, and E, which are respectively the first detection channel A, the second detection channel B, the third detection channel C, the fourth detection channel D, and the fifth detection channel E. The first detection channel A is connected to the first dual-purpose signal line 19-1 via the signal acquisition terminal 1 of the first bidirectional switch 55-1; the second detection channel B is connected to the second dual-purpose signal line 19-2 via the signal acquisition terminal 1 of the second bidirectional switch 55-2; the third detection channel C is connected to the third dual-purpose signal line 19-3 via the signal acquisition terminal 1 of the third bidirectional switch 55-3; the fourth detection channel D is connected to the fourth dual-purpose signal line 19-4 via the signal acquisition terminal 1 of the fourth bidirectional switch 55-4; and the fifth detection channel E is connected to the fifth dual-purpose signal line 19-5 via the signal acquisition terminal 1 of the fifth bidirectional switch 55-5. Each detection channel A, B, C, D, and E is used to receive the temperature detection signal acquired by the temperature detection unit 35 corresponding to the electrode unit 33 connected to the corresponding dual-purpose signal line 19. In addition, each detection channel A, B, C, D, and E is connected to the first power supply module 58, which provides detection voltage to the detection channel A, B, C, D, and E, via a corresponding voltage divider resistor 53 in the adapter 20. The first power supply module 58 provides DC power. In this embodiment, the first communication unit 56 is configured to acquire digital signals output by multiple ADC units 52 and send the digital signals to the electric field generator 30. The electric field generator 30 is also configured to control and adjust the voltage of the alternating electrical signal provided to the multiple electrode units 33 of the electrode sheet 13 according to the received digital signals. For example, when any digital signal among the multiple received digital signals exceeds a preset threshold, it indicates that the temperature detected by the temperature detection unit 35 corresponding to at least one electrode unit 33 in the electrode sheet 13 exceeds the preset temperature threshold (e.g., 41°C, 42°C, etc.). At this time, the voltage of the alternating electrical signal output by the electric field generator 30 can be appropriately reduced to avoid the electrode unit 33 of the electrode sheet 13 from becoming too hot when the alternating electrical signal is applied, causing low-temperature burns to the patient's skin. The above-mentioned preset temperature threshold and preset threshold can be based on human safety thresholds.The determination is made. The first communication unit 56 is controlled by the first controller 51 and serially transmits the digital signals converted by multiple ADC units 52. In this embodiment, the preset temperature threshold can be a value within the range of 36℃-45℃.

[0059] Referring to Figures 5 and 6, in this embodiment, the first power module 58 is electrically connected to the second power module 32 of the electric field generator 30 and is configured to supply power to the first controller 51, multiple ADC units 52, and the first communication unit 56 of the adapter 20. Each electrode 13 is connected to the adapter 20 by a first connector 60, which is adapted to connect the corresponding electrode 13 to the adapter 20. As shown in Figure 1, the first connector 60 includes a first plug 61 located at the end of the first cable 15 away from the electrode 13 and a first socket 62 located on the adapter 20. The first plug 61 and the first socket 62 are press-type spring connectors, that is, the first connector 60 connects the adapter 20 and the electrode 13 by means of a connector. Each first cable 15 has 5 wires electrically connected to the corresponding bidirectional switch 55 in the corresponding set of bidirectional switch 55 and 4 wires electrically connected to the corresponding control switch 54 in the corresponding set of control switches 54. That is, each first connector 60 is electrically connected to the corresponding set of bidirectional switch 55 and the corresponding set of control switches 54 of the adapter 20 through 9 wires, and is connected to the electric field generator 30 through the corresponding alternating power line 57 of the adapter 20.

[0060] A second connector 70 is provided between the adapter 20 and the electric field generator 30. The second connector 70 is adapted to connect the electric field generator 30 to the adapter 20. As shown in FIG1, the adapter 20 also includes a second cable 25 connected to the second connector 70. The second connector 70 includes a second plug 71 located at the end of the second cable 25 away from the first controller 51 and a second socket 72 located on the electric field generator 30. The second plug 71 and the second socket 72 are push-button spring connectors, meaning the second connector 70 connects the adapter 20 to the electric field generator 30 using a connector method. Each first connector 60, such as X1, Y1, X2, and Y2, is connected to the second connector 70 via a corresponding alternating power line 57. The first connectors 60, such as X1, Y1, X2, and Y2, are also connected to a corresponding set of control switches 54 and a corresponding set of ADC units 52. Each first connector 60 is connected to the second connector 70 and the corresponding set of ADC units 52 via a corresponding set of bidirectional switching switches 55. The second cable 25 has eight wires, including four wires 1 to 4 that are electrically connected to the corresponding alternating power lines 57 for transmitting alternating electrical signals, one wire 5 that is electrically connected to the data receiving line RX of the first communication unit 56, and one wire connected to the first communication unit 56...The data transmission line TX is electrically connected to the wire 6, the wire 7 is electrically connected to the VCC power line of the first power module 58, and the wire 8 is electrically connected to the GND line of the first power module 58. The second connector 70 is connected to the first communication unit 56 through the data receiving line RX and the data transmission line TX. The VCC pin of the second connector 70 is connected to the VVC power line of the first power module 58, and the GND pin of the second connector 70 is connected to the GND line of the first power module 58 and grounded. The VCC pin of the second connector 70 is also connected to the corresponding group voltage resistors 53 and the corresponding group ADC units 52 through the VCC power line of the first power module 58.

[0061] Referring to FIG5 and FIG7, the electric field generator 30 includes: a second power module 32, a second controller 37, an AC signal generator 39, a second communication unit 38, and a set of power supply switches 40. The VCC pin of the second connector 70 is also electrically connected to the VCC power line of the second power module 32, and the GND pin of the second connector 70 is grounded through the GND line of the second power module 32. The second power module 32 is also connected to and supplies power to the second controller 37 and the AC signal generator 39, respectively. The second communication unit 38 is electrically connected to the wire 5 of the second connector 70 through its data receiving line RX and to the wire 6 of the second connector 70 through its data transmitting line TX, thereby realizing information interaction between the electric field generator 30 and the adapter 20. The second controller 37 is also electrically connected to the second communication unit 38, the AC signal generator 39, and a set of power switches 40. The second controller 37 is configured to control the opening and closing of each power switch 40 in the set of power switches 40 and adjust the relevant parameters of the alternating electrical signal applied by the AC signal generator 39 according to the relevant digital signals received from the adapter 20 by the second communication unit 38. The AC signal generator 39 is electrically connected to the second connector 70 via a set of power supply switches 40 and wires 1 to 4 for transmitting alternating electrical signals. The set of power supply switches 40 includes multiple power supply switches 40, each corresponding to one of the electrode plates 13. Each power supply switch 40 is electrically connected to a corresponding wire 1, 2, 3, or 4 in the second connector 70 via an AC power line 41-1, 41-2, 41-3, or 41-4, and then electrically connected to the corresponding electrode plate 13 via corresponding wires 1, 2, 3, or 4 in the second connector 70, to deliver an alternating electrical signal to each electrode plate 13. The AC signal generator 39 is electrically connected to this set of power supply switches 40 via multiple AC power lines 41. Specifically, the number of power supply switches 40 in the electric field generator 30 is related to the number of electrode plates 13; in this embodiment, the number of power supply switches 40 and the number of electrode plates 13 are equal and both are four. The power supply switches 40 include...The first power supply switch 40-1, the second power supply switch 40-2, the third power supply switch 40-3, and the fourth power supply switch 40-4 are electrically connected to the wires 1 to 4 of the second connector 70, respectively. One end of the first power supply switch 40-1 is electrically connected to the AC signal generator 39 via the AC power line 41 of the electric field generator 30, and the other end is electrically connected to the corresponding wire 1 for transmitting alternating electrical signals in the second connector 70 via an AC power line 41-1, and connected to the adapter 20 via the wire 1 of the second connector 70. The alternating power line 57 located at port X1 is electrically connected to the first connector 60, and the first connector 60 located at port X1 of the adapter 20 is electrically connected to the corresponding electrode plate 13, so as to control whether the AC signal generator 39 transmits an alternating electrical signal to the electrode plate 13 electrically connected to port X1 of the adapter 20; one end of the second power supply switch 40-2 is electrically connected to the AC signal generator 39 through the AC power line 41 of the electric field generator 30, and the other end is connected to the corresponding electrode plate 13 in the second connection 70 through an AC power line 41-2. The conductor 2 transmitting the alternating electrical signal is electrically connected to the alternating power line 57 at port Y1 of the adapter 20 via the conductor 2 of the second connector 70. The alternating power line 57 at port Y1 of the adapter 20 is electrically connected to the first connector 60. The first connector 60 at port Y1 of the adapter 20 is electrically connected to the corresponding electrode 13 to control whether the AC signal generator 39 supplies alternating electrical signals to the electrode 13 electrically connected to port Y1 of the adapter 20. One end of the third power supply switch 40-3 is connected to the AC signal generator via the AC power line 41 of the electric field generator 30. 39 is electrically connected, and the other end is electrically connected to the corresponding conductor 3 transmitting alternating electrical signals in the second connection 70 via an AC power line 41-3. It is also electrically connected to the AC power line 57 at port X2 of the adapter 20 via the conductor 3 of the second connector 70. The AC power line 57 at port X2 of the adapter 20 is electrically connected to the first connector 60. The first connector 60 at port X2 of the adapter 20 is electrically connected to the corresponding electrode piece 13, thereby controlling whether the AC signal generator 39 supplies alternating electrical signals to the electrode piece 13 electrically connected to port X2 of the adapter 20; the fourth power supply... One end of the electric switch 40-4 is electrically connected to the AC signal generator 39 via the AC power line 41 of the electric field generator 30, and the other end is electrically connected to the corresponding conductor 4 transmitting alternating electrical signals in the second connection 70 via an AC power line 41-4, and electrically connected to the AC power line 57 located at port Y2 of the adapter 20 via the conductor 4 of the second connector 70. The AC power line 57 located at port Y2 of the adapter 20 is electrically connected to the first connector 60, and the first connector 60 located at port Y2 of the adapter 20 is electrically connected to the corresponding electrode plate 13, so as to control the AC signal generator 39.Whether to supply an alternating electrical signal to the electrode 13 electrically connected to port Y1 of adapter 20.

[0062] The working principle of the tumor electric field therapy system 100 of this embodiment will be described in detail below with reference to Figures 3 to 5.

[0063] Specifically, when it is necessary to detect the temperature at each electrode unit 33 of an electrode plate 13, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controls the signal acquisition terminal 1 of each of the multiple bidirectional switching switches 55 electrically connected to the electrode plate 13 to be turned on and the signal input terminal 2 to be turned off, so as to disconnect the alternating electrical signal applied to the electrode plate 13; at the same time, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controls each of the control switches 54 electrically connected to the electrode plate 13 to be turned on sequentially and time-divisionally. At this time, the temperature detection signals collected by each temperature detection unit 35 corresponding to each electrode unit 33 of each row of the electrode plate 13 can be collected sequentially and time-divisionally through the multiple detection channels A, B, C, D, E of a group of ADC units 52 corresponding to the electrode plate 13. Each detection channel A, B, C, D, and E of each ADC unit 52 in each row simultaneously acquires only the temperature detection signal of the temperature detection unit 35 corresponding to each electrode unit 33 in the same row group of the electrode plate 13. The temperature detection signal can be characterized by voltage value. Only one of the four control switches 54 in the group corresponding to the electrode plate 13 can be turned on at any given time, while the other three are turned off. All five bidirectional switching switches 55 in the group corresponding to the ADC unit 52 are switched to their respective signal acquisition terminals 1 so that each dual-purpose signal line 19 of the electrode plate 13 is electrically connected to the corresponding detection channels A, B, C, D, and E of the corresponding ADC unit 52, thus enabling conduction. With this configuration, the ADC unit 52 can acquire the voltage values ​​of all temperature detection units 35 corresponding to each electrode unit 33 in the same row group that are shorted by a grounding wire 18 corresponding to the turned-on control switch 54.

[0064] Specifically, when control switch 54-1 is closed, control switches 54-2, 54-3, and 54-4 are all open, and the first bidirectional switching switch 55-1, the second bidirectional switching switch 55-2, the third bidirectional switching switch 55-3, the fourth bidirectional switching switch 55-4, and the fifth bidirectional switching switch 55-5 are all switched to their respective signal acquisition terminals 1, the temperature detection units 35 corresponding to electrode units 33-1 to 33-5 in the first row group are energized, and the temperature detection units 35 corresponding to electrode units 33-6 to 33-20 in the remaining row groups are de-energized. The electrode on the first detection channel A in the ADC unit 52 of this group is short-circuited.Since only the grounding terminal 35-1 of the temperature detection unit 35 corresponding to electrode unit 33-1 is connected to ground, while the grounding terminals 35-1 of the temperature detection unit 35 corresponding to electrode unit 33-6, electrode unit 33-11, and electrode unit 33-16 are disconnected, and each temperature detection unit 35 includes a temperature sensor 34 and a diode 36 connected in series with the temperature sensor 34, it will not affect the resistance value of the temperature detection unit 35 corresponding to electrode unit 33-1. Therefore, only the temperature detection unit 35 corresponding to electrode unit 33-1 is effectively operating on the first detection channel A of this ADC unit 52. The temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-1. Similarly, the voltage value acquired on the second detection channel B in this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-2. The voltage value acquired on the third detection channel C in this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-3. The voltage value acquired on the fourth detection channel D in this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-4. The voltage value acquired on the fifth detection channel E in this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-5.

[0065] When control switch 54-2 is closed, control switches 54-1, 54-3, and 54-4 are all open, and the first bidirectional switching switch 55-1, the second bidirectional switching switch 55-2, the third bidirectional switching switch 55-3, the fourth bidirectional switching switch 55-4, and the fifth bidirectional switching switch 55-5 are all switched to their respective signal acquisition terminals 1, the temperature detection units 35 corresponding to electrode units 33-6 to 33-10 in the second row group are energized, and the temperature detection units 35 corresponding to electrode units 33-1 to 33-5 and electrode units 33-11 to 33-20 in the other rows are de-energized. The ADC unit 52 in this group... In the first detection channel A, the signal terminals 35-2 of the temperature detection units 35 corresponding to electrode units 33-1, 33-6, 33-11, and 33-16 are shorted. Since only the ground terminal 35-1 of the temperature detection unit 35 corresponding to electrode unit 33-6 is grounded, while the ground terminals 35-1 of the temperature detection units 35 corresponding to electrode units 33-1, 33-11, and 33-16 are open, and each temperature detection unit 35 includes a temperature sensor 34 and a...The diode 36 connected in series with sensor 34 does not affect the resistance value of the temperature detection unit 35 corresponding to electrode unit 33-6. Therefore, only the temperature detection unit 35 corresponding to electrode unit 33-6 is effectively operating on the first detection channel A of this ADC unit 52. When this is the case (page 13 / 46, CN 121371480 A), the temperature detection signal (voltage value) acquired by the first detection channel A is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-6. Similarly, the voltage value acquired on the second detection channel B of this ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-7. The voltage value acquired on the third detection channel C of this ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-8. The voltage value acquired on the fourth detection channel D of this ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-9. The voltage value acquired on the fifth detection channel E in this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-10.

[0066] When control switch 54-3 is closed, control switches 54-1, 54-2, and 54-4 are all open, and the first bidirectional switching switch 55-1, the second bidirectional switching switch 55-2, the third bidirectional switching switch 55-3, the fourth bidirectional switching switch 55-4, and the fifth bidirectional switching switch 55-5 are all switched to their respective signal acquisition terminals 1, the temperature detection units 35 corresponding to electrode units 33-11 to 33-15 in the third row group are powered on, and the temperature detection units 35 corresponding to electrode units 33-1 to 33-10 and electrode units 33-16 to 33-20 in the other rows are de-powered, and this group of ADC units 52 In the first detection channel A, the signal terminals 35-2 of the temperature detection units 35 corresponding to electrode units 33-1, 33-6, 33-11, and 33-16 are shorted. Since only the ground terminal 35-1 of the temperature detection unit 35 corresponding to electrode unit 33-11 is grounded, while the ground terminals 35-1 of the temperature detection units 35 corresponding to electrode units 33-1, 33-6, and 33-16 are open, and each temperature detection unit 35 includes a temperature sensor 34 and a diode 36 connected in series with the temperature sensor 34, it will not affect the resistance value of the temperature detection unit 35 corresponding to electrode unit 33-11. Therefore, only the temperature detection unit 35 corresponding to electrode unit 33-11 is effectively operating on the first detection channel A of this ADC unit 52. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-11. Similarly, the voltage value acquired on the second detection channel B in this ADC unit 52 is the electrode voltage.The voltage value of temperature detection unit 35 corresponding to unit 33-12. The voltage value collected on the third detection channel C in this group of ADC units 52 is the voltage value of temperature detection unit 35 corresponding to electrode unit 33-13. The voltage value collected on the fourth detection channel D in this group of ADC units 52 is the voltage value of temperature detection unit 35 corresponding to electrode unit 33-14. The voltage value collected on the fifth detection channel E in this group of ADC units 52 is the voltage value of temperature detection unit 35 corresponding to electrode unit 33-15.

[0067] When control switch 54-4 is closed, control switches 54-1, 54-2, and 54-3 are all open, and the first bidirectional switching switch 55-1, the second bidirectional switching switch 55-2, the third bidirectional switching switch 55-3, the fourth bidirectional switching switch 55-4, and the fifth bidirectional switching switch 55-5 are all switched to their respective signal acquisition terminals 1. The temperature detection units 35 corresponding to electrode units 33-16 to 33-20 in the fourth row group are energized, while the temperature detection units 35 corresponding to electrode units 33-1 to 33-15 in the other rows are de-energized. The signal terminals 35-2 of the temperature detection units 35 corresponding to electrode units 33-1, 33-6, 33-11, and 33-16 in the first detection channel A of the ADC unit 52 in this group are short-circuited. Since only the grounding terminal 35-1 of the temperature detection unit 35 corresponding to electrode unit 33-16 is grounded, while the grounding terminals 35-1 of the temperature detection units 35 corresponding to electrode units 33-1, 33-6, and 33-11 are all disconnected, and each temperature detection unit 35 includes a temperature sensor 34 and a diode 36 connected in series with the temperature sensor 34, the resistance value of the temperature detection unit 35 corresponding to electrode unit 33-16 will not be affected. Therefore, only the temperature detection unit 35 corresponding to electrode unit 33-16 is effectively operating on the first detection channel A of this group of ADC units 52. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-16. Similarly, the voltage value collected on the second detection channel B of this group of ADC units 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-17. The voltage value acquired on the third detection channel C of this ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-18. The voltage value acquired on the fourth detection channel D of this ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-19 (page 14 / 46 of the manual, CN 121371480 A). The voltage value acquired on the fifth detection channel E of this ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-20.

[0068] Therefore, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 can acquire the temperature detection signals of the temperature detection units 35 corresponding to all electrode units 33 of a certain electrode piece 13 by controlling a set of bidirectional switching switches 55 and a set of control switches 54, all of which are electrically connected to a certain electrode piece 13. That is, the switching unit (unlabeled) is configured to switch the dual-purpose signal lines 19 corresponding to at least two column groups to be connected to the corresponding temperature sampling points (unlabeled) at the same time, and the switching state of the corresponding control switches 54 is configured so that the temperature detection signals detected by the corresponding temperature detection units 35 in each row group are sampled based on the corresponding temperature sampling points (unlabeled). Similarly, the temperature detection signals of the temperature detection units 35 corresponding to each electrode unit 33 of other electrode pieces 13 can be obtained.

[0069] The first controller 51 or the second controller 37, the multiple ADC units 52, and the multiple bidirectional switching switches 55 can automatically perform operations through pre-programmed program code. For example, the first controller 51 or the second controller 37 first controls all the bidirectional switching switches 55 in the corresponding group to switch to the signal acquisition terminal 1, so that all the signal acquisition terminals 1 of these bidirectional switching switches 55 are turned on and all the signal input terminals 2 are turned off, so that each dual-purpose signal line 19 of the corresponding electrode plate 13 is electrically connected to the corresponding group of ADC units 52. Then, the control switch 54-1 in the corresponding group of control switches 54 is closed, and the remaining control switches 54-2 to 54-4 in the group of control switches 54 are turned off. During this period, each detection channel A, B, C, D, and E of the group of ADC units 52 acquires the temperature detection signal of each temperature detection unit 35 corresponding to each electrode unit 33 in the first row of the corresponding electrode plate 13, converts it into a digital signal, and stores it in a separately set memory. Then, after a preset time interval, The first controller 51 or the second controller 37 then closes control switch 54-2 in the group of control switches 54, and opens control switches 54-1, 54-3 and 54-4 in the group of control switches 54. During this period, each detection channel A, B, C, D and E of the ADC unit 52 acquires the temperature detection signal of each temperature detection unit 35 corresponding to each electrode unit 33 in the second row group. By sequentially turning on each control switch 54 in the group of control switches 54, the temperature detection signal of all temperature detection units 35 on the electrode plate 13 can be obtained. Similarly, the temperature detection signal of all temperature detection units 35 on at least one pair of electrode plates 13 can be obtained through this operation.

[0070] It should be noted that in some other embodiments, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 can also control a group of bidirectional switching switches 55 and a group of control switches 54 electrically connected to a certain electrode plate 13 to achieve the same temperature acquisition time period, the temperature detection unit corresponding to some electrode units 33 of the electrode plate 13.Acquisition of temperature detection signals at 35°C. For example, when only the first bidirectional switch 55-1 is switched to its signal acquisition terminal 1, switch 54-1 can be closed first, and switches 54-2, 54-3, and 54-4 can be opened. At this time, only the temperature detection unit 35 corresponding to the electrode unit 33-1 of the first row group is energized. The signal terminal 35-2 of the temperature detection unit 35 corresponding to the electrode unit 33-1 is short-circuited on the first detection channel A of the ADC unit 52 of this group. Therefore, the ADC unit 52 of this group will detect the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-1. Then, control switch 54-2 is closed, and control switches 54-1, 54-2, 54-3, and 54-4 are opened. When both switch 54-3 and control switch 54-4 are open, the ADC unit 52 will detect the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-6. Then, control switch 54-3 is closed, and control switches 54-1, 54-2, and 54-4 are all open. The ADC unit 52 will then detect the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-11. Finally, control switch 54-4 is closed, and control switches 54-1, 54-2, and 54-3 are all open. The ADC unit 52 will then detect the voltage value of the temperature detection unit 35 corresponding to electrode unit 33-16. Therefore, within the same acquisition time period, only the temperature detection signal of the temperature detection unit 35 corresponding to one column of electrode units 33 can be sampled. Similarly, the temperature detection signals of the temperature detection units 35 corresponding to other columns of electrode units 33 can be sampled during other acquisition time periods. That is, the switching unit (unlabeled) is configured to switch the dual-purpose signal line 19 corresponding to each column group to the corresponding temperature sampling point (unlabeled), as specified on page 15 / 46 of the specification (CN 121371480 A). The switching state of the control switch 54 is configured so that the temperature detection signals detected by each temperature detection unit 35 in each column group are sampled separately. It should be noted that in some other embodiments, the temperature detection signals of the temperature detection units 35 corresponding to two, three, or four column groups of electrode units 33 can also be sampled within the same acquisition time period; details will not be elaborated here.

[0071] Specifically, when it is necessary to apply an alternating electrical signal to each electrode unit 33 of an electrode plate 13, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controls the signal input terminal 2 of each of the multiple bidirectional switching switches 55 electrically connected to the electrode plate 13 to be turned on and the signal acquisition terminal 1 to be turned off, and controls a power supply switch 40 electrically connected to the electrode plate 13 to be turned on. At this time, the second controller of the electric field generator 30...The device 37 controls the AC signal generator 39 to apply alternating electrical signals to each electrode unit 33 of the electrode plate 13 through the alternating power line 57, and the magnitude of the applied alternating electrical signal voltage or current is adjustable. That is, the switching unit (unlabeled) is configured to switch at least two column groups of dual-purpose signal lines 19 to be connected to the alternating power line 57 at the same time, so that at least two column groups of electrode units 33 are simultaneously applied alternating electrical signals based on the alternating power line 57.

[0072] It should be noted that, in some other embodiments, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 can also control a set of bidirectional switching switches 55 electrically connected to a certain electrode plate 13 to apply alternating electrical signals to some electrode units 33 of the electrode plate 13 at the same time period. For example, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controls the signal input terminal 2 of the first bidirectional switch 55-1 of a group of bidirectional switches 55 electrically connected to the electrode plate 13 to be turned on and the signal acquisition terminal 1 to be turned off, and controls a power supply switch 40 electrically connected to the electrode plate 13 to be turned on. At this time, the second controller 37 of the electric field generator 30 controls the AC signal generator 39 to apply an alternating electrical signal to the first column group electrode units 33-1, 33-6, 33-11, and 33-16 of the electrode plate 13 through the alternating power supply line 57, and the magnitude of the applied alternating electrical signal voltage or current is adjustable. That is, the switching unit (unlabeled) is configured to switch the dual-purpose signal line 19 corresponding to each column group to be connected to the alternating power supply line 57 respectively, so that the electrode units 33 of each column group are simultaneously applied with an alternating electrical signal based on the alternating power supply line 57. It should be noted that in some other embodiments, alternating electrical signals can be applied simultaneously to two, three, or four rows of electrode units 33 within the same time period. Detailed descriptions will not be provided here.

[0073] It should be noted that in this embodiment, the control switch 54, which is electrically connected to each of the multiple grounding lines 18 of the electrode sheet 13, and the bidirectional switching switch 55, which is electrically connected to each of the multiple dual-purpose signal lines 19 of the electrode sheet 13, are both located in the adapter 20. However, in other embodiments, the control switch 54, which is electrically connected to the grounding line 18, and the bidirectional switching switch 55, which is electrically connected to the dual-purpose signal lines 19, can also be located on the electrode sheet 13 or in the electric field generator 30. Further details will not be provided here. Furthermore, the ADC unit 52 located in the adapter 20 can also be located in the electric field generator 30 and directly controlled by the second controller 37.

[0074] The tumor electric field therapy system 100 of this application can achieve real-time temperature monitoring of all electrode units 33 on the electrode sheet 13 without increasing the weight of the electrode sheet 13 or increasing the number of wire cores in the first cable 15 electrically connected to the electrode sheet 13.Comprehensive monitoring allows for the determination of whether electrode pad 13 is qualified based on the obtained temperature detection signal; or the determination of whether the temperature detection unit 35 of electrode pad 13 is faulty or abnormal based on the obtained temperature detection signal, and the determination of whether electrode pad 13 needs to be replaced based on the number of faulty or abnormal temperature detection units 35; or the identification of electrode pad type based on the obtained temperature detection signal if the electrode pad is qualified; or the determination of whether the electrode unit 33 of electrode pad 13 is overheated based on the obtained temperature detection signal if the electrode pad is qualified, and the control of the alternating electrical signal applied to electrode pad 13 or the corresponding column of electrode units 33 of electrode pad 13, thereby avoiding low-temperature burns to the patient's body surface during tumor treatment through electrode pad 13. Furthermore, the electrode sheet specification of this application (pages 16 / 46, 20 CN 121371480 A 13) describes a substrate 31 that is electrically connected to the signal terminals 35-2 of the same electrode unit 33 and its corresponding temperature detection unit 35 via a single dual-purpose signal line 19. This allows for the transmission of both alternating current signals and DC signals for temperature signal acquisition, along with the acquired temperature detection signals, via the dual-purpose signal line 19. Simultaneously, it significantly reduces the number of conductive traces (grounding line 18, dual-purpose signal line 19) on the substrate, lowering the wiring complexity of the substrate 31, simplifying the manufacturing process, reducing the weight of the substrate 31, and lowering manufacturing costs. The electrode sheet 13 of this application can also switch between applying alternating current signals for tumor treatment and transmitting DC signals for temperature acquisition and the acquired temperature detection signals through a combination of a control switch 54 electrically connected to the grounding line 18 and a bidirectional switching switch 55 electrically connected to the dual-purpose signal line 19.

[0075] Specifically, when it is necessary to apply alternating electrical signals to the patient through each electrode unit 33 of an electrode pad 13, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controls all control switches 54 in a set of control switches 54 corresponding to the electrode pad 13 to be disconnected, and at the same time controls all bidirectional switching switches 55 in a set of bidirectional switching switches 55 corresponding to the electrode pad 13 to be switched to their respective signal input terminals 2, so that the signal acquisition terminals 1 of these bidirectional switching switches 55 are all disconnected and the signal input terminals 2 are all turned on, so that each dual-purpose signal line 19 of the electrode pad 13 is electrically connected to an alternating power supply line 57 corresponding to the adapter 20 and the electrode pad 13, thereby transmitting the alternating electrical signals to each electrode unit 33 of the electrode pad 13. When the temperature detection signals of the temperature detection units 35 corresponding to all electrode units 33 of the electrode pad 13 are much lower than the preset temperature threshold stored in the electric field generator 30 or the adapter 20, the electric field generator 30, through its firstThe second controller 37 controls the AC signal generator 39 to continue generating alternating electrical signals with increasing or constant voltage or current amplitudes, which are then transmitted to the corresponding electrode plates 13 via an alternating power line 57 of the adapter 20, so that the alternating electrical signals continue to be applied to the electrode plates 13. When the temperature detection signals of the temperature detection units 35 corresponding to all electrode units 33 of the electrode plate 13 are lower than but close to the preset temperature threshold stored in the electric field generator 30 or the adapter 20, the electric field generator 30 can reduce the voltage or current of the alternating electrical signals generated by the AC signal generator 39 through the second controller 37, thereby reducing the voltage or current of the alternating electrical signals applied to the electrode plates 13. When the temperature detection signal of the temperature detection unit 35 corresponding to an electrode unit 33 of a certain electrode plate 13 is detected to be greater than the preset temperature threshold, the electric field generator 30 controls the power supply switch 40 electrically connected to the electrode plate 13 to disconnect through the second controller 37, so as to stop the power supply to the electrode plate 13. An alternating electrical signal is applied; or the second controller 37 of the electric field generator 30 or the first controller 21 of the adapter 20 controls all bidirectional switching switches 55 in a set of bidirectional switching switches 55 electrically connected to the electrode 13 to switch from their signal input terminal 2 to their signal acquisition terminal 1, that is, all bidirectional switching signal acquisition terminals 1 of all bidirectional switching switches 55 in a set of bidirectional switching switches 55 electrically connected to the electrode 13 are turned on and all signal input terminals 2 are turned off, thereby stopping the application of alternating electrical signals to the electrode 13; or, when the temperature detection signal of the temperature detection unit 35 corresponding to an electrode unit 33 of a certain electrode 13 is detected to be greater than a preset temperature threshold, the second controller 37 of the electric field generator 30 controls the power supply switch 40 electrically connected to the electrode 13 to continue to be turned on, and the second controller 37 of the electric field generator 30 or the first controller 21 of the adapter 20 controls a bidirectional switching switch 55 electrically connected to the electrode unit 33 of the electrode 13 to switch from its signal input terminal 2 to its signal acquisition terminal 1 ... to switch from its signal input terminal 2 to its signal acquisition terminal 1, and the second controller 37 of the electric field generator 30 or the first controller The controller 21 simultaneously controls the remaining bidirectional switching switches 55, which are electrically connected to electrode units 33 in different columns from those of electrode units 33 whose temperature detection signals exceed the preset temperature threshold, to remain electrically connected to their respective signal input terminals 2. This stops applying alternating electrical signals to all electrode units 33 in the column where the temperature detection signals of the electrode unit 13 exceed the preset temperature threshold, and continues to apply alternating electrical signals to the remaining column electrode units 33 whose temperature detection signals do not exceed the preset temperature threshold. This achieves the alternating electrical signal application control method based on temperature detection signals in the tumor electric field therapy system 100. (Instruction manual 17 / 46 pages 21 CN 121371480 A

[0076] )This application provides an electrode temperature detection method, applied to the electrode 13 or the tumor electric field therapy system 100 described above. Referring to FIG8, it includes the following steps:

[0077] Step 210: Control the switching unit to connect the dual-purpose signal line 19 corresponding to at least one column group in the corresponding electrode 13 to the corresponding temperature sampling point.

[0078] Specifically, control the bidirectional switching switch 55 electrically connected to each electrode unit 33 of the electrode 13 to disconnect the alternating electrical signal applied to each electrode unit 33 of the electrode 13 and simultaneously connect the DC electrical signal applied to the signal terminal 35-2 of the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode 13.

[0079] Further, the bidirectional switching switch 55 electrically connected to each electrode unit 33 of the electrode sheet 13 is switched from the end electrically connected to the alternating current signal to the end electrically connected to the direct current signal, that is, the bidirectional switching switch 55 electrically connected to the electrode sheet 13 is switched from its signal input terminal 2 to its signal acquisition terminal 1; or, the bidirectional switching switch 55 electrically connected to each electrode unit 33 of the electrode sheet 13 is controlled to switch each electrode unit 33 of the electrode sheet 13 from the conducting state to the disconnected state, and at the same time, the signal terminal 35-2 of the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode sheet 13 is switched from the disconnected state to the conducting state.

[0080] Step 220: Control the control switch 54 corresponding to each row group so as to sample the analog temperature signal of the corresponding electrode unit 33 based on the corresponding temperature sampling point.

[0081] Specifically, the control switch 54, which is electrically connected to the ground terminal 35-1 of the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode sheet 13, is turned on in a time-division manner to obtain the temperature detection signal of the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode sheet 13.

[0082] In some embodiments, when the dual-purpose signal line 19 corresponding to each column group is connected to the corresponding temperature sampling point, the control switch 54 corresponding to each row group is controlled, including: controlling the control switch 54 corresponding to each row group to close sequentially, so as to sample the analog temperature signal of each electrode unit 33 in each column group.

[0083] In other embodiments, when the dual-purpose signal line 19 corresponding to at least two column groups is simultaneously connected to the corresponding temperature sampling point, the control switch 54 corresponding to each row group is controlled, including: controlling the control switch 54 corresponding to each row group to close sequentially, so as to sample the analog temperature signal of the corresponding electrode unit 33 in each row group.

[0084] The electrode temperature detection method of this application can quickly and accurately obtain the temperature of all electrode units of the electrode sheet; and can determine whether the temperature detection units of the electrode sheet are faulty, abnormal, or whether the electrode sheet is qualified and needs to be replaced based on the obtained temperature detection signals of all temperature detection units of the electrode sheet; it can also be used on the electrode sheetUnder normal conditions, the temperature detection units of the electrode sheet determine whether each electrode unit of the electrode sheet is overheated based on the temperature detection signals of all temperature detection units of the electrode sheet, and then control the alternating electrical signal applied to the electrode sheet or each electrode unit of the electrode sheet; the electrode sheet type can also be identified when the temperature detection signals of each temperature detection unit of the electrode sheet are normal.

[0085] The first controller 51 or electric field generator 30 in the adapter 20 of the tumor electric field therapy system 100 of this application embodiment is provided with a preset threshold, a first preset temperature, a second preset temperature and a preset temperature threshold, wherein the first preset temperature is lower than the second preset temperature and the second preset temperature is lower than the preset temperature threshold.

[0086] Referring to FIG9, this application also provides an electrode sheet temperature abnormality detection method, which includes the following steps:

[0087] Step 210: Control the switching unit so that the dual-purpose signal line 19 corresponding to at least one column group in the corresponding electrode sheet 13 is connected to the corresponding temperature sampling point.

[0088] Step 220: Control the control switch 54 corresponding to each row group so as to sample the analog temperature signal of the corresponding electrode unit 33 based on the corresponding temperature sampling point, so as to determine the temperature detection signal at each electrode unit 33 in each electrode sheet 13.

[0089] Step 230: Determine whether the electrode sheet 13 is abnormal based on the temperature detection signal.

[0090] In some embodiments, step 230, determining whether the electrode sheet 13 is abnormal based on the temperature detection signal, specifically includes the following steps:

[0091] Step 231: Compare the temperature at each electrode unit 33 in the corresponding electrode sheet 13 with a preset temperature threshold based on the temperature detection signal. Specifically, the temperature detection signal detected by the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 can be compared with the preset temperature threshold.

[0092] Step 232: Determine whether the temperature of the electrode sheet 13 is abnormal based on the comparison result. Specifically, the comparison results determine whether there is a temperature abnormality in each electrode unit 33 of the electrode sheet 13.

[0093] The comparison results in step 232 include not exceeding a preset temperature threshold and exceeding a preset temperature threshold. Not exceeding the preset temperature threshold includes being much lower than the preset temperature threshold and being close to the preset temperature threshold. The preset temperature threshold is 40℃-42℃. Optionally, the preset temperature threshold is 40.5℃-41.5℃. Optionally, the preset temperature threshold is 41℃-41.5℃. Optionally, the preset temperature threshold is 41℃.

[0094] The process of determining whether the temperature of the electrode sheet 13 is abnormal based on the comparison results in step 232 is as follows: if the temperature at any electrode unit 33 in the corresponding electrode sheet 13 exceeds the preset temperature threshold, it is determined that the electrode sheet 13The temperature is abnormal. If the temperature at all electrode units 33 in the corresponding electrode sheet 13 does not exceed the preset temperature threshold, it is determined that the temperature of the electrode sheet 13 is not abnormal.

[0095] In some other embodiments, step 230, determining whether the electrode sheet 13 is abnormal based on the temperature detection signal, specifically includes the following steps:

[0096] Step 233: If it is determined that any electrode unit 33 in the corresponding electrode sheet 13 is abnormal or malfunctioning based on the temperature detection signal, the electrode sheet 13 is determined to be unqualified.

[0097] Specifically, based on the temperature detection signal detected by the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13, it is determined whether the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 is abnormal or malfunctioning; then, based on whether the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 is abnormal or malfunctioning, it is determined whether the electrode sheet 13 is qualified. Wherein, when the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 is abnormal or malfunctions, the electrode sheet 13 is determined to be unqualified; when the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 is not abnormal or malfunctions, the electrode sheet 13 is determined to be qualified.

[0098] In some other embodiments, the step 230 of determining whether the electrode sheet 13 is abnormal based on the temperature detection signal specifically includes the following steps:

[0099] Step 234: If it is determined that there is an abnormal or malfunctioning electrode unit 33 in the corresponding electrode sheet 13 based on the temperature detection signal, determine the number of abnormal or malfunctioning electrode units 33.

[0100] Step 235: If the number of abnormal or malfunctioning electrode units 33 reaches a preset threshold, it is determined that the electrode sheet 13 needs to be replaced.

[0101] Specifically, based on the temperature detection signals of the temperature detection units 35 corresponding to each electrode unit 33 in the electrode sheet 13, it is determined whether the temperature detection units 35 corresponding to each electrode unit 33 in the electrode sheet 13 are abnormal or faulty; then, based on whether the temperature detection units 35 corresponding to each electrode unit 33 in the electrode sheet 13 are abnormal or faulty, it is determined whether the electrode sheet 13 needs to be replaced.

[0102] For example, when the temperature detection units 35 corresponding to each electrode unit 33 in the electrode sheet 13 are abnormal or faulty and the number of abnormal or faulty temperature detection units 35 exceeds a preset threshold, it is determined that the electrode sheet 13 needs to be replaced; when the number of abnormal or faulty temperature detection units 35 in the electrode sheet instruction manual (page 19 / 46, CN 121371480 A 13) does not exceed the preset threshold, it is determined that the electrode sheet 13 does not need to be replaced. The preset threshold is 20% of the total number of temperature detection units 35 in the electrode sheet 13.

[0103] Referring to FIG10, this application also provides a control method for a tumor electric field therapy system, which includes the following steps:

[0104] Step 210: Control the switching unit so that the dual-purpose signal line 19 corresponding to at least one column group in the corresponding electrode sheet 13 is connected to the corresponding temperature sampling point.

[0105] Step 220: Control the control switch 54 corresponding to each row group so as to sample the analog temperature signal of the corresponding electrode unit 33 based on the corresponding temperature sampling point to determine the temperature detection signal of each electrode unit 33 in each electrode sheet 13.

[0106] Step 240: Control the intensity of the alternating electrical signal applied to the electrode unit 33 according to the temperature detection signal.

[0107] Specifically, when it is determined that the electrode sheet 13 does not need to be replaced, the alternating electrical signal applied to each electrode unit 33 in the electrode sheet 13 is controlled or adjusted according to the temperature detection signal detected by the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13. That is, steps 234-235 can be added between steps 240 and 220.

[0108] In some embodiments, controlling the intensity of the alternating electrical signal applied to the electrode unit 33 based on the temperature detection signal in step 240 specifically includes the following steps:

[0109] Step 241: Compare the temperature at each electrode unit 33 in the electrode sheet 13 with a preset temperature threshold based on the temperature detection signal.

[0110] Step 242: Control the intensity of the alternating electrical signal based on the comparison result.

[0111] In some embodiments, controlling the intensity of the alternating electrical signal based on the comparison result in step 242 specifically includes:

[0112] Step 2421: If the temperature at at least one electrode unit 33 exceeds the preset temperature threshold, stop applying the alternating electrical signal to the electrode unit 33 of the electrode sheet 13. Specifically, when any temperature detection signal among the acquired temperature detection signals of all electrode units 33 of the electrode sheet 13 exceeds the preset temperature threshold, stop applying the alternating electrical signal to the electrode unit 33 of the electrode sheet 13. When the temperature detection signals of each electrode unit 33 in the electrode sheet 13 do not exceed the preset temperature threshold, alternating electrical signals continue to be applied to each electrode unit 33 in the electrode sheet 13.

[0113] In some embodiments, stopping the application of alternating electrical signals to the electrode units 33 in the electrode sheet 13 in step 2421 specifically includes: stopping the application of alternating electrical signals to all electrode units 33 in the electrode sheet 13; or stopping the application of alternating electrical signals to all electrode units 33 in the column group where the electrode unit 33 exceeds the preset temperature threshold in the electrode sheet 13.

[0114] Further, when stopping the application of alternating electrical signals to all electrode units 33 in the column group where the electrode unit 33 exceeds the preset temperature threshold in the electrode sheet 13, alternating electrical signals continue to be applied to the electrode units 33 in other columns in the electrode sheet 13.Electrical signal. The intensity of the alternating electrical signal applied to the electrode units 33 in other columns of the electrode sheet 13 is adjustable. For example, all electrode units 33 in the electrode sheet 13 whose temperature detection signal does not exceed a preset temperature threshold and are in different columns from the electrode units 33 whose temperature detection signal exceeds the preset temperature threshold are still subject to an alternating electrical signal, and this signal is adjustable.

[0115] In some other embodiments, controlling the intensity of the alternating electrical signal according to the comparison result in step 242 specifically includes:

[0116] Step 2422: If the temperature at all electrode units 33 in the electrode sheet 13 does not exceed a preset temperature threshold, and if the temperature at all electrode units 33 in the electrode sheet 13 does not exceed a first preset temperature, then the intensity of the alternating electrical signal applied to the electrode units 33 of the electrode sheet 13 is increased, wherein the first preset temperature is less than the preset temperature threshold.

[0117] In step 2422, the electric field intensity increases by the same amount for each column group whose alternating electrical signal intensity is increased. Instruction manual, page 20 / 46, CN 121371480 A

[0118] Step 2423: If the temperature at all electrode units 33 in the electrode sheet 13 does not exceed the preset temperature threshold, and if the temperature at at least one electrode unit 33 in the electrode sheet 13 exceeds the first preset temperature but is less than the second preset temperature, then the alternating electrical signal intensity currently applied to the electrode unit 33 of the electrode sheet 13 remains unchanged.

[0119] Step 2424: If the temperature at all electrode units 33 in the electrode sheet 13 does not exceed the preset temperature threshold, and if the temperature at at least one electrode unit 33 in the electrode sheet 13 exceeds the second preset temperature but is less than the preset temperature threshold, then the alternating electrical signal intensity applied to the electrode unit 33 of the electrode sheet 13 is reduced, wherein the second preset temperature is greater than the first preset temperature but less than the preset temperature threshold.

[0120] In step 2424, the electric field intensity reduction is the same for each column group whose alternating electrical signal intensity is reduced.

[0121] For example, when the temperature detection signal is much lower than a preset temperature threshold, the alternating electrical signal is continued to be applied to each electrode unit 33 of the electrode sheet 13 by increasing the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13, or by keeping the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13 constant. When the temperature detection signal is close to the preset temperature threshold, the alternating electrical signal is continued to be applied to each electrode unit 33 of the electrode sheet 13 by keeping the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13 constant, or by decreasing the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13.Alternating electrical signal.

[0122] In some other embodiments, controlling the intensity of the alternating electrical signal based on the comparison result in step 242 specifically includes:

[0123] Step 2425: If the temperature at at least one electrode unit 33 exceeds a preset temperature threshold, determine the number of overheating groups.

[0124] Step 2426: If the number of overheating groups exceeds a preset number threshold, stop applying the alternating electrical signal to all electrode units 33 of the electrode sheet 13.

[0125] Step 2427: If the number of overheating groups does not exceed the preset number threshold, stop applying the alternating electrical signal to all electrode units 33 in the column group where the electrode unit 33 exceeds the preset temperature threshold in the electrode sheet 13.

[0126] Further, if the alternating electrical signal is stopped from being applied to all electrode units 33 in the column group where the electrode unit 33 exceeds the preset temperature threshold in the electrode sheet 13, the alternating electrical signal continues to be applied to the electrode units 33 in other columns of the electrode sheet 13. The alternating electrical signal intensity applied to the electrode units 33 in other columns of the electrode sheet 13 is adjustable.

[0127] Step 2428: If the number of overheated columns does not exceed a preset threshold, and the temperature at each electrode unit 33 in the non-overheated columns does not exceed a first preset temperature, the alternating electrical signal intensity applied to the electrode units 33 in the non-overheated columns is increased, wherein the first preset temperature is less than a preset temperature threshold.

[0128] In step 2428, the electric field intensity increases by the same amount for each column whose alternating electrical signal intensity is increased.

[0129] Step 2429: If the number of overheated columns does not exceed a preset threshold, and the temperature at at least one electrode unit 33 in the non-overheated columns exceeds the first preset temperature but is less than a preset temperature threshold, the alternating electrical signal intensity currently applied to the electrode units 33 in the non-overheated columns remains unchanged.

[0130] Step 2430: If the number of overheated groups does not exceed a preset threshold, and if at least one electrode unit 33 in the non-overheated groups has a temperature exceeding a second preset temperature but less than a preset temperature threshold, then the intensity of the alternating electrical signal applied to the electrode unit 33 in the non-overheated groups is reduced, wherein the second preset temperature is greater than the first preset temperature and less than the preset temperature threshold.

[0131] In step 2430, the electric field intensity corresponding to each group whose alternating electrical signal intensity is reduced is reduced by the same amount.

[0132] For example, when the temperature detection signal is much lower than the preset temperature threshold, the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13 continues to be applied by increasing the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13.An alternating electrical signal is applied to each electrode unit 33 of the electrode sheet 13, or the alternating electrical signal is applied to each electrode unit 33 of the electrode sheet 13 in a manner that keeps the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13 constant. When the temperature detection signal approaches a preset temperature threshold, the alternating electrical signal is applied to each electrode unit 33 of the electrode sheet 13 in a manner that keeps the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13 constant, or the alternating electrical signal is applied to each electrode unit 33 of the electrode sheet 13 in a manner that reduces the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33 of the electrode sheet 13.

[0133] Referring to FIG11, this application also provides an electrode sheet type identification method, which includes the following steps:

[0134] Step 210: Control the switching unit to connect the dual-purpose signal line 19 corresponding to at least one column group in the corresponding electrode sheet 13 to the corresponding temperature sampling point.

[0135] Step 220: Control the control switch 54 corresponding to each row group so as to sample the analog temperature signal of the corresponding electrode unit 33 based on the corresponding temperature sampling point, so as to determine the temperature detection signal of each electrode unit 33 in each electrode sheet 13.

[0136] Step 250: Identify the type of electrode sheet 13 according to the temperature detection signal.

[0137] Specifically, when the electrode sheet 13 is qualified or the temperature detection unit 35 of the electrode sheet 13 is not abnormal or has no fault, the type of electrode sheet 13 is identified according to the temperature detection signal detected by the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13.

[0138] This application also provides a signal control method for tumor electric field therapy, used in the above-mentioned tumor electric field therapy system 100 or for the above-mentioned electrode sheet 13. The method includes: combining the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode sheet 13 to switch each electrode unit 33 of the electrode sheet 13 between applying an alternating electrical signal and collecting a temperature detection signal.

[0139] Referring to FIG12, this application also provides a signal control method for tumor electric field therapy, used for the above-mentioned electrode sheet 13. The method includes:

[0140] Step 310: Combining control switches 54 and bidirectional switching switches 55 electrically connected to the corresponding electrode sheet 13 to apply alternating electrical signals to each electrode unit 33 of the electrode sheet 13 and executing step 320;

[0141] Step 320: Combining control switches 54 and bidirectional switching switches 55 electrically connected to the electrode sheet 13 to collect temperature detection signals of each electrode unit 33 of the electrode sheet 13 in a row and executing step 330;

[0142] Step 330: Determining the combination control mode of control switches 54 and bidirectional switching switches 55 electrically connected to the electrode sheet 13 according to the collected temperature detection signals and executing step 340;

[0143] Step 340: Control the working state of each electrode unit 33 of the electrode sheet 13 according to the determined combination control method of control switch 54 and bidirectional switching switch 55.

[0144] The working state of each electrode unit 33 of the electrode sheet 13 in step 340 includes at least one of the following: stopping the application of alternating current signal and continuing to collect temperature detection signal, and stopping the collection of temperature detection signal and continuing to apply alternating current signal. Continuing to apply alternating current signal includes continuing to apply alternating current signal by increasing the voltage or current amplitude of the currently applied alternating current signal, or continuing to apply alternating current signal by keeping the voltage or current amplitude of the currently applied alternating current signal unchanged, or continuing to apply alternating current signal by decreasing the voltage or current amplitude of the currently applied alternating current signal.

[0145] The working state of each electrode unit 33 of the electrode sheet 13 is determined by the temperature detection signal it collects. Each electrode unit 33 of the electrode sheet 13 is divided into different regions. By combining the control switch 54 and the bidirectional switching switch 55, each electrode unit 33 in each region can be cyclically switched between applying an alternating electrical signal and acquiring a temperature detection signal.

[0146] This application embodiment provides another method for detecting the temperature of an electrode sheet in a tumor electric field therapy system 100. Referring to FIG13, the temperature detection method includes:

[0147] Step 510: Disconnect the input of the alternating electrical signal of the electrode sheet 13, perform combined control of multiple control switches 54 and multiple bidirectional switching switches 55, and obtain the temperature detection signal of the temperature detection unit 35 of the electrode sheet 13 corresponding to each combination;

[0148] Step 520: Sample and convert the temperature detection signal detected by each temperature detection unit 35 in the electrode sheet 13 to obtain a digital temperature signal;

[0149] Step 530: Transmit the digital temperature signal to the electric field generator 30 of the tumor electric field therapy system 100 so that the electric field generator 30 can determine the temperature at the corresponding electrode unit 33 according to the digital temperature signal.

[0150] In step 510, the combined control of multiple control switches 54 and multiple bidirectional switching switches 55 specifically includes:

[0151] Step 511: Place all bidirectional switching switches 55 at the signal acquisition terminal 1 to conduct the electrical connection between the signal terminals 35-2 of each temperature detection unit 35 corresponding to each electrode unit 33 and the corresponding ADC unit 52;

[0152] Step 512: Sequentially close one of the multiple control switches 54 individually to acquire the temperature detection signals detected by each temperature detection unit 35 corresponding to each electrode unit 33 in the corresponding row group.

[0153] In step 512, sequentially closing one of the multiple control switches 54 individually allows the ADC unit 52 to connect with the closed switch.The detection channels of each temperature detection unit 35 in the row group corresponding to the control switch 54 are electrically connected and turned on.

[0154] Thus, the temperature detection signals of each temperature detection unit 35 in each row group can be obtained sequentially, and then processed by the adapter 20 or the electric field generator 30 to obtain the temperature corresponding to all electrode units 33 on the electrode sheet 13, so that the temperature detection of the patient's body surface is more comprehensive and accurate.

[0155] For the tumor electric field therapy system 100 of this application embodiment, the temperature of a single electrode unit 33 can also be detected as needed. The specific process of the method for detecting the temperature of a certain electrode unit 33 of the electrode sheet 13 is as follows: disconnect the input of the alternating current signal, place the bidirectional switching switch 55 corresponding to the column group where the electrode unit 33 that needs to be measured individually is located at the signal acquisition terminal 1, and place the remaining bidirectional switching switches 55 at the signal input terminal 2; at the same time, turn on and ground the control switch 54 corresponding to the row group where the electrode unit 33 that needs to be measured individually is located, and turn off all the remaining control switches 54. Therefore, the temperature detection signal of the temperature detection unit 35 corresponding to the electrode unit 33 that needs to be measured individually can be sampled to obtain the temperature of the electrode unit 33. For example, if the electrode unit 33 that needs to be measured individually is electrode unit 33-1, then the bidirectional switch 55-1 corresponding to electrode unit 33-1 is placed at signal acquisition terminal 1, and the remaining bidirectional switches (55-2 to 55-5) are all placed at signal input terminal 2; at the same time, the control switch 18-1 corresponding to electrode unit 33-1 is closed and grounded, and the remaining control switches (18-2 to 18-4) are all opened. Thus, the temperature of electrode unit 33-1 can be detected.

[0156] This application embodiment also provides another method for applying alternating electrical signals for tumor electric field therapy, applied to the tumor electric field therapy system 100 described above. Referring to FIG14, the alternating electrical signal application method includes:

[0157] Step 610: Determine the region (1-5) in the electrode sheet 13 where the electrode unit 33 to which the alternating electrical signal needs to be applied is located;

[0158] Step 611: Combine and control multiple control switches 54 and multiple bidirectional switching switches 55 electrically connected to the electrode sheet 13 to apply the alternating electrical signal. Instruction manual, pages 23 / 46, CN 121371480 A

[0159] Step 611, which combines multiple control switches 54 and multiple bidirectional switching switches 55 electrically connected to the electrode plate 13, specifically includes:

[0160] Step 612: Disconnect all control switches 54 electrically connected to the electrode plate 13;

[0161] Step 613: Determine the column group of the electrode units 33 in the areas where alternating electrical signals need to be applied, based on the determined column group of the electrode units 33 in the areas where alternating electrical signals need to be applied;

[0162] Step 614: Determine the column group of the electrode units 33 in the areas where alternating electrical signals need to be applied, based on the determined column group of the electrode units 33 in the areas where alternating electrical signals need to be applied.The electrode unit 33 in the group is electrically connected to the bidirectional switching switch 55;

[0163] Step 615: Control the bidirectional switching switch 55 electrically connected to the electrode unit 33 that needs to be applied with alternating current signal so that the electrode unit 33 that needs to be applied with alternating current signal is electrically connected to the alternating power supply line 57 to apply alternating current signal; at the same time, control the remaining bidirectional switching switches 55 to disconnect the electrical connection between each electrode unit 33 in the area where alternating current signal does not need to be applied and the alternating power supply line 57 to stop applying alternating current signal.

[0164] In step 615, “connecting the electrode unit that needs to be applied with an alternating electrical signal to the alternating power line 57 to apply the alternating electrical signal and disconnecting the electrical connection between the electrode unit 33 in the area where no alternating electrical signal needs to be applied and the alternating power line 57 to stop applying the alternating electrical signal” is achieved by placing the bidirectional switching switch 55, which is electrically connected to the electrode unit 33 in the column group corresponding to the area (1-5) in the electrode sheet 13 where the alternating electrical signal needs to be applied, at its signal input terminal 2, and placing all the bidirectional switching switches 55, which are electrically connected to the electrode unit 33 in the remaining column groups, at the signal acquisition terminal 1.

[0165] The first controller 51 or electric field generator 30 in the adapter 20 of the tumor electric field therapy system 100 of this application embodiment is provided with a preset quantity threshold, a first preset temperature t1, a second preset temperature t2 and a preset temperature threshold t0, wherein the first preset temperature t1 is lower than the second preset temperature t2, and the second preset temperature t2 is lower than the preset temperature threshold t0.

[0166] This application embodiment also provides a method for applying alternating electrical signals based on temperature detection signals, used in the above-mentioned tumor electric field therapy system 100. Referring to FIG15, the application method includes:

[0167] Step 710: Start the tumor electric field therapy system 100;

[0168] Step 711: Combine the control switch 54 (also called grounding switch) and the bidirectional switching switch 55 electrically connected to the corresponding electrode sheet 13 to apply alternating electrical signals to each electrode unit 33 of the electrode sheet 13;

[0169] Step 712: Combine the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode sheet 13 to obtain the temperature of each electrode unit 33 of the electrode sheet 13;

[0170] Step 713: Determine whether there is an electrode unit 33 with a temperature exceeding a first preset temperature t1. If there is no electrode unit 33 with a temperature exceeding the first preset temperature t1, execute step 714. If there is an electrode unit 33 with a temperature exceeding the first preset temperature t1, execute step 715;

[0171] Step 714: Continue applying alternating current signals to each electrode unit 33 of electrode sheet 13 by increasing the voltage or current amplitude of the currently applied alternating current signal and return to step 712;

[0172] Step 715: Determine whether there is an electrode unit 33 with a temperature exceeding the second preset temperature t2; when there is no temperature exceeding...When the electrode unit 33 reaches the second preset temperature t2, step 716 is executed; when there is an electrode unit 33 with a temperature exceeding the second preset temperature t2, step 717 is executed;

[0173] Step 716: Continue to apply alternating electrical signals to each electrode unit 33 of the electrode sheet 13 in a manner that keeps the voltage or current amplitude of the currently applied alternating electrical signal constant and return to step 712;

[0174] Step 717: Determine whether there is an electrode unit 33 with a temperature exceeding the preset temperature threshold t0. If there is no electrode unit 33 with a temperature exceeding the preset temperature threshold t0, step 718 is executed; if there is an electrode unit with a temperature exceeding the preset temperature threshold t0, step 719 is executed; Specification 24 / 46 pages 28 CN 121371480 A

[0175] Step 718: Continue to apply alternating electrical signals to all electrode units 33 of the electrode sheet 13 in a manner that reduces the voltage or current amplitude of the currently applied alternating electrical signal and return to step 712;

[0176] Step 719: Determine the number of overheated areas and execute step 720, wherein the overheated area is the area containing electrode units whose temperature exceeds the preset temperature threshold t0, and the non-overheated area is the area where the temperature of all electrode units does not exceed the preset temperature threshold t0;

[0177] Step 720: Determine whether the number of overheated areas exceeds the preset number threshold. If the number of overheated areas exceeds the preset number threshold, execute step 721; if the number of overheated areas does not exceed the preset number threshold, execute step 724;

[0178] Step 721: Stop applying alternating electrical signals to each electrode unit 33 of the electrode sheet 13 and execute step 722;

[0179] Step 722: Combine the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode sheet 13 to obtain the temperature of each electrode unit 33 of the electrode sheet 13 and execute step 723;

[0180] Step 723: Determine whether there is an electrode unit 33 with a temperature exceeding the first preset temperature t1. If there is no electrode unit 33 with a temperature exceeding the first preset temperature t1 on the electrode sheet 13, return to step 711. If there is an electrode unit 33 with a temperature exceeding the first preset temperature t1 on the electrode sheet 13, return to step 722.

[0181] Step 724: Distinguish between overheated and non-overheated regions based on whether there is an electrode unit 33 with a temperature exceeding the preset temperature threshold t0. If the region is an overheated region, execute step 725. If the region is a non-overheated region, execute step 726.

[0182] Step 725: Stop applying alternating electrical signals to each electrode unit 33 in the overheated region and execute step 731.

[0183] Step 726: Determine whether the temperature of each electrode unit 33 in the non-overheated region does not exceed the first preset temperature t1. If the temperature of each electrode unit 33 in the non-overheated region does not exceed the first preset temperature t1, execute step 727. If the temperature of each electrode unit 33 in the non-overheated region does not exceed the first preset temperature t1, execute step 727.When the temperature of any electrode unit 33 in the overheated region exceeds the first preset temperature t1, step 728 is executed;

[0184] Step 727: Continue to apply alternating current signals to each electrode unit 33 in the non-overheated region of the electrode sheet 13 by increasing the voltage or current amplitude of the currently applied alternating current signal and execute step 731;

[0185] Step 728: Determine whether the temperature of each electrode unit 33 in the non-overheated region does not exceed the second preset temperature t2. When the temperature of each electrode unit 33 in the non-overheated region does not exceed the second preset temperature t2, step 729 is executed. When the temperature of any electrode unit 33 in the non-overheated region exceeds the second preset temperature t2, step 730 is executed;

[0186] Step 729: Continue to apply alternating current signals to each electrode unit 33 in the non-overheated region of the electrode sheet 13 by keeping the voltage or current amplitude of the currently applied alternating current signal unchanged and execute step 731;

[0187] Step 730: Continue applying alternating current signals to each electrode unit 33 in the non-overheated area of ​​electrode sheet 13 by reducing the voltage or current amplitude of the currently applied alternating current signal and execute step 731;

[0188] Step 731: Combine the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode sheet 13 to reacquire the temperature of each electrode unit 33 of the electrode sheet 13 and select to execute step 732 or step 734. The temperature of each electrode unit 33 of the electrode sheet 13 includes the temperature of each electrode unit 33 in the overheated area and the temperature of each electrode unit 33 in the non-overheated area;

[0189] Step 732: Determine whether the temperature of each electrode unit 33 in the overheated area does not exceed the first preset temperature t1. If the temperature of each electrode unit 33 in the overheated area does not exceed the first preset temperature t1, execute step 733. If there is a temperature in each electrode unit 33 in the overheated area that exceeds the first preset temperature t1, return to step 731;

[0190] Step 733: Redetermine the area as a non-overheating area and execute step 734;

[0191] Step 734: Determine whether the temperature of each electrode unit 33 in the obtained non-overheating area does not exceed the first preset temperature t1. If the temperature of each electrode unit 33 in the non-overheating area does not exceed the first preset temperature t1, execute step 735. If there is a temperature in each electrode unit 33 in the non-overheating area that exceeds the first preset temperature t1, execute step 736; Specification 25 / 46 pages 29 CN 121371480 A

[0192] Step 735: Continue to apply alternating electrical signals to each electrode unit 33 in the non-overheating area by increasing the voltage or current amplitude of the currently applied alternating electrical signal and return to step 712;

[0193] Step 736: Determine whether the temperature of each electrode unit 33 in the obtained non-overheating area does not exceed the second preset temperature t1.Let temperature t2. When the temperature of each electrode unit 33 in the non-overheated area does not exceed the second preset temperature t2, execute step 737. When there is a temperature in each electrode unit 33 in the non-overheated area that exceeds the second preset temperature t2, execute step 738.

[0194] Step 737: Continue to apply alternating current signals to each electrode unit 33 in the non-overheated area while keeping the voltage or current amplitude of the currently applied alternating current signal unchanged, and return to step 712.

[0195] Step 738: Determine whether the temperature of each electrode unit 33 in the non-overheated area does not exceed the preset temperature threshold t0. When the temperature of each electrode unit 33 in the non-overheated area does not exceed the preset temperature threshold t0, execute step 739. When there is a temperature in each electrode unit 33 in the non-overheated area that exceeds the preset temperature threshold t0, return to step 719.

[0196] Step 739: Continue to apply alternating electrical signals to each electrode unit 33 in the non-overheated area by reducing the voltage or current amplitude of the currently applied alternating electrical signal and return to step 712.

[0197] Specifically, the process of combining the control switches 54 and bidirectional switching switches 55 electrically connected to the corresponding electrode plates 13 in step 711 to apply alternating electrical signals to each electrode unit 33 of the electrode plate is as follows:

[0198] Disconnect all control switches 54 electrically connected to the corresponding electrode plates 13, and simultaneously switch all bidirectional switching switches 55 electrically connected to the corresponding electrode plates 13 to the end that applies alternating electrical signals to each electrode unit 33; or

[0199] Disconnect all control switches 54 electrically connected to the corresponding electrode plates 13, and simultaneously switch all bidirectional switching switches 55 electrically connected to the corresponding electrode plates 13 to the end that connects each electrode unit 33 to the alternating power line 57; or

[0200] Disconnect all control switches 54 electrically connected to the corresponding electrode plates 13, and simultaneously switch all bidirectional switching switches 55 electrically connected to the corresponding electrode plates 13 to their respective signal input terminals 2.

[0201] The process of obtaining the temperature of each electrode unit 33 of the electrode plate 13 in steps 712, 722, and 731 is specifically as follows:

[0202] Control the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch all of its end that applies alternating electrical signals to each electrode unit 33 to its end that collects temperature data from each electrode unit 33, and sequentially close the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode plate 13 to obtain the temperature of each electrode unit 33 of the electrode plate 13; or

[0203] Control the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch all of its signal input terminal 2 that applies alternating electrical signals to each electrode unit 33 to its signal acquisition terminal 1, and sequentially close the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode plate 13.The control switch 54, electrically connected to the temperature detection unit 35 corresponding to the electrode 13, is used to obtain the temperature of each electrode unit 33 of the electrode plate 13; or

[0204] the bidirectional switching switch 55 electrically connected to the electrode plate 13 is controlled to switch the electrode plate 13 from being electrically connected to the alternating power line 57 to being electrically connected to the temperature detection unit 35 corresponding to each electrode unit 33 and the corresponding analog-to-digital converter 53, and the control switch 54 electrically connected to the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode plate 13 is closed in sequence at different times to obtain the temperature of each electrode unit 33 of the electrode plate 13; or

[0205] the bidirectional switching switch 55 electrically connected to the electrode plate 13 is controlled to switch the electrode plate 13 from transmitting alternating electrical signals to transmitting direct current signals or temperature detection signals, and the control switch 54 electrically connected to the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode plate 13 is closed in sequence at different times to obtain the temperature of each electrode unit 33 of the electrode plate 13.

[0206] The first preset temperature in steps 713, 723, 726, 732, and 734 is 40℃-40.3℃, preferably 40.2℃. The second preset temperature in steps 715, 728, and 736 is 40.4℃ to 40.6℃, preferably 40.5℃; the preset temperature threshold in steps 717 and 738 is 41℃ to 41.5℃, preferably 41℃; the preset quantity threshold in step 720 (page 26 / 46 of the specification, 30 CN 121371480 A) is preferably 2.

[0207] The process of continuing to apply the alternating electrical signal as described in steps 714, 716, 718, 727, 729, 730, 735, 737, and 739 is specifically as follows:

[0208] Disconnect the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied, and simultaneously control the bidirectional switching switch 55 electrically connected to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied to conduct the alternating electrical signal transmission path electrically connected to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied to, thereby continuing to apply the alternating electrical signal to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied; or

[0209] The control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 that needs to continue applying alternating electrical signals is disconnected, and at the same time, the bidirectional switching switch 55 electrically connected to the electrode unit 33 that needs to continue applying alternating electrical signals is switched from its respective signal acquisition terminal 1 to its respective signal input terminal 2, so as to continue applying alternating electrical signals to the electrode unit 33 that needs to continue applying alternating electrical signals; or

[0210] The control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 that needs to continue applying alternating electrical signals is disconnected, and at the same time, the bidirectional switching switch 55 electrically connected to the electrode unit 33 that needs to continue applying alternating electrical signals is switched from its respective signal acquisition terminal 1 to its respective signal input terminal 2, so as to continue applying alternating electrical signals to the electrode unit 33; or

[0210] The control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 that needs to continue applying alternating electrical signals is disconnected, and at the same time, the bidirectional switching switch 55 electrically connected to the electrode unit 33 that needs to continue applying alternating electrical signals is switched from its respective signal acquisition terminal 1 to its respective signal input terminal 2.Each of the signal input terminals 2 is electrically connected to the alternating power supply line 57 to continue applying alternating signals to the electrode unit 33 that needs to continue applying alternating signals; or

[0211] the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 that needs to continue applying alternating signals is disconnected, and at the same time, the bidirectional switching switch 55 electrically connected to the electrode unit 33 that needs to continue applying alternating signals is controlled so that its respective signal input terminal 2 is closed and the signal acquisition terminal 1 is disconnected, so that the alternating signals continue to be applied to the electrode unit 33 that needs to continue applying alternating signals; or

[0212] the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 that needs to continue applying alternating signals is disconnected, and at the same time, the bidirectional switching switch 55 electrically connected to the electrode unit 33 that needs to continue applying alternating signals is controlled so that the electrode unit 33 that needs to continue applying alternating signals switches from transmitting temperature detection signals to applying alternating signals.

[0213] The increase in the voltage or current amplitude of the currently applied alternating current signal in steps 714, 727, and 735 specifically involves boosting the voltage of the currently applied alternating current signal by increasing the DC voltage amplitude by 0.03V per second.

[0214] The continued application of the alternating current signal by decreasing the voltage or current amplitude of the currently applied alternating current signal in steps 718, 730, and 739 specifically involves continuing to apply the alternating current signal by decreasing its voltage amplitude by 5V for 3 minutes.

[0215] The process of stopping the application of alternating electrical signals to each electrode unit 33 of the electrode plate 13 in step 721 is specifically as follows:

[0216] Controlling the bidirectional switching switch 55 electrically connected to the electrode plate 13 to disconnect the electrical connection between each electrode unit 33 of the electrode plate 13 and the alternating power supply line 57; or

[0217] Controlling the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch all of its ends that apply alternating electrical signals to each electrode unit 33 to its ends that perform temperature acquisition on each electrode unit 33; or

[0218] Controlling the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch all of its signal input terminals 2 that apply alternating electrical signals to each electrode unit 33 to its signal acquisition terminals 1; or

[0219] Controlling the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch the electrode plate 13 from the electrical connection between each electrode unit 33 and the alternating power supply line 57 to the temperature detection unit 35 and the corresponding analog-to-digital converter 53 corresponding to each electrode unit 33. Electrical connection; or specification page 27 / 46, 31 CN 121371480 A

[0220] Controlling the bidirectional switching switch 55 electrically connected to the electrode plate 13 causes each electrode unit 33 of the electrode plate 13 to switch from transmitting alternating electrical signals to transmitting direct current signals or temperature detection signals from the corresponding temperature detection unit 35.

[0221] The process of stopping the application of alternating electrical signals to each electrode unit 33 in the over-temperature zone as described in step 725 specifically includes:

[0222] Controlling the bidirectional switching switch 55 electrically connected to each electrode unit 33 in the over-temperature zone to disconnect the electrical connection between each electrode unit 33 in the over-temperature zone and the alternating power line 57; or

[0223] Controlling the bidirectional switching switch 55 electrically connected to each electrode unit 33 in the over-temperature zone to switch all its terminals from the end that applies alternating electrical signals to each electrode unit 33 in the over-temperature zone to the end that performs temperature acquisition by each electrode unit 33 in the over-temperature zone; or

[0224] Controlling the bidirectional switching switch 55 electrically connected to each electrode unit 33 in the over-temperature zone to switch all its signal input terminals 2 that apply alternating electrical signals to each electrode unit 33 in the over-temperature zone to its signal acquisition terminals 1; or

[0225] The bidirectional switching switch 55, which controls the electrical connection of each electrode unit 33 in the overheated area, switches each electrode unit 33 in the overheated area from being electrically connected to the alternating power line 57 to being electrically connected to its corresponding temperature detection unit 35 and its corresponding analog-to-digital converter 53; or

[0226] the bidirectional switching switch 55, which controls the electrical connection of each electrode unit 33 in the overheated area, switches each electrode unit 33 in the overheated area from transmitting alternating electrical signals to transmitting direct current signals or temperature detection signals through its corresponding temperature detection unit 35.

[0227] In the above control method, the tumor electric field therapy system 100 includes at least two pairs of electrode plates 13 to alternately apply alternating electric fields with different directions, and each electrode plate 13 can alternately switch between applying alternating electrical signals and transmitting temperature detection signals.

[0228] The first controller 51 or electric field generator 30 in the adapter 20 of the tumor electric field therapy system 100 of this application embodiment is further provided with a third preset temperature t3, which is higher than the second preset temperature t2 but still lower than the preset temperature threshold t0. The third preset temperature t3 is closer to the preset temperature threshold t0 than the second preset temperature t2. This application also provides an alternating electrical signal control method based on a temperature detection signal for the aforementioned tumor electric field therapy system. Referring to Figure 16, the alternating electrical signal control method includes:

[0229] Step 810: Starting the tumor electric field therapy system 100;

[0230] Step 811: Combining the control switch 54 (also called a grounding switch) and the bidirectional switching switch 55 electrically connected to the corresponding electrode sheet 13 to apply an alternating electrical signal to each electrode unit 33 of the electrode sheet 13;

[0231] Step 812: Combining the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode sheet 13 to obtain the temperature of each electrode unit 33 of the electrode sheet 13;

[0232] Step 813: Determining whether there is an electrode unit 33 with a temperature exceeding the first preset temperature t1. If there is no electrode unit 33 with a temperature exceeding the first preset temperature t1, step 814 is executed. If there is an electrode unit 33 with a temperature exceeding the first preset temperature t1...When unit 33 is in operation, step 815 is executed;

[0233] Step 814: Continue to apply alternating electrical signals to each electrode unit 33 of electrode sheet 13 by increasing the voltage or current amplitude of the currently applied alternating electrical signal and return to step 812;

[0234] Step 815: Determine whether there is an electrode unit 33 with a temperature exceeding the second preset temperature t2; if there is no electrode unit 33 with a temperature exceeding the second preset temperature t2, execute step 816; if there is an electrode unit 33 with a temperature exceeding the second preset temperature t2, execute step 817;

[0235] Step 816: Continue to apply alternating electrical signals to each electrode unit 33 of electrode sheet 13 by keeping the voltage or current amplitude of the currently applied alternating electrical signal unchanged and return to step 812; Specification 28 / 46 pages 32 CN 121371480 A

[0236] Step 817: Determine if there is an electrode unit 33 with a temperature exceeding the third preset temperature t3. If there is no electrode unit 33 with a temperature exceeding the third preset temperature t3, proceed to step 818; if there is an electrode unit with a temperature exceeding the third preset temperature t3, proceed to step 819;

[0237] Step 818: Continue to apply alternating electrical signals to all electrode units 33 of the electrode sheet 13 by reducing the voltage or current amplitude of the currently applied alternating electrical signal and return to step 812;

[0238] Step 819: Determine if there is an electrode unit 33 with a temperature exceeding the preset temperature threshold t0. If there is no electrode unit 33 with a temperature exceeding the preset temperature threshold t0, proceed to step 820; if there is an electrode unit with a temperature exceeding the preset temperature threshold t0, proceed to step 821;

[0239] Step 820: Continue to apply alternating electrical signals to all electrode units 33 of the electrode sheet 13 by reducing the voltage or current amplitude of the currently applied alternating electrical signal and return to step 812;

[0240] Step 821: Determine the number of overheated areas and execute step 822, wherein the overheated area is the area containing electrode units whose temperature exceeds the preset temperature threshold t0, and the non-overheated area is the area where the temperature of all electrode units does not exceed the preset temperature threshold t0;

[0241] Step 822: Determine whether the number of overheated areas exceeds the preset number threshold. If the number of overheated areas exceeds the preset number threshold, execute step 823. If the number of overheated areas does not exceed the preset number threshold, execute step 826;

[0242] Step 823: Stop applying alternating electrical signals to each electrode unit 33 of the electrode sheet 13 and execute step 824;

[0243] Step 824: Combine the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode sheet 13 to obtain the temperature of each electrode unit 33 of the electrode sheet 13 and execute step 825;

[0244] Step 825: Determine whether there is an electrode unit 33 that exceeds the first preset temperature t1. If there is no electrode unit 33 with a temperature exceeding the first preset temperature t1, execute step 825.When the temperature of an electrode unit 33 exceeds the first preset temperature t1, return to step 811; when there is an electrode unit 33 in the electrode sheet 13 with a temperature exceeding the first preset temperature t1, return to step 824;

[0245] Step 826: Distinguish between overheated and non-overheated regions based on whether there is an electrode unit 33 with a temperature exceeding the preset temperature threshold t0. When the region is an overheated region, execute step 827; when the region is a non-overheated region, execute step 828;

[0246] Step 827: Stop applying alternating electrical signals to each electrode unit 33 in the overheated region and execute step 835;

[0247] Step 828: Determine whether the temperature of each electrode unit 33 in the non-overheated region does not exceed the first preset temperature t1. When the temperature of each electrode unit 33 in the non-overheated region does not exceed the first preset temperature t1, execute step 829; when there is a temperature in each electrode unit 33 in the non-overheated region that exceeds the first preset temperature t1, execute step 830;

[0248] Step 829: Continue applying alternating current signals to each electrode unit 33 in the non-temperature-exceeding area of ​​electrode sheet 13 by increasing the voltage or current amplitude of the currently applied alternating current signal and execute step 835;

[0249] Step 830: Determine whether the temperature of each electrode unit 33 in the non-temperature-exceeding area does not exceed the second preset temperature t2. If the temperature of each electrode unit 33 in the non-temperature-exceeding area does not exceed the second preset temperature t2, execute step 831. If there is a temperature in each electrode unit 33 in the non-temperature-exceeding area that exceeds the second preset temperature t2, execute step 832;

[0250] Step 831: Continue applying alternating current signals to each electrode unit 33 in the non-temperature-exceeding area of ​​electrode sheet 13 by keeping the voltage or current amplitude of the currently applied alternating current signal unchanged and execute step 835;

[0251] Step 832: Determine whether there is an electrode unit 33 in the non-overheated area whose temperature exceeds the third preset temperature t3. If the temperature of all electrode units 33 in the non-overheated area does not exceed the third preset temperature t3, execute step 833. If there is a temperature in any of the electrode units 33 in the non-overheated area that exceeds the third preset temperature t3, execute step 834.

[0252] Step 833: Continue to apply alternating electrical signals to each electrode unit 33 in the non-overheated area by reducing the voltage or current amplitude of the currently applied alternating electrical signal and execute step 835.

[0253] Step 834: Continue to apply alternating electrical signals to each electrode unit 33 in the non-overheated area of ​​the electrode sheet 13 by further reducing the voltage or current amplitude of the currently applied alternating electrical signal and execute step 835.

[0254] Step 835: Combine the control switch 54 and the bidirectional switching switch 55, which are electrically connected to the electrode plate 13, to re-Obtain the temperature of each electrode unit 33 of the electrode sheet 13 and select to execute step 836 or step 838. The temperature of each electrode unit 33 of the electrode sheet 13 includes the temperature of each electrode unit 33 in the overheated area and the temperature of each electrode unit 33 in the non-overheated area;

[0255] Step 836: Determine whether the temperature of each electrode unit 33 in the overheated area does not exceed the first preset temperature t1. If the temperature of each electrode unit 33 in the overheated area does not exceed the first preset temperature t1, execute step 837. If there is a temperature in each electrode unit 33 in the overheated area that exceeds the first preset temperature t1, return to step 835;

[0256] Step 837: Redetermine the area as the non-overheated area and execute step 838;

[0257] Step 838: Determine whether the obtained temperature of each electrode unit 33 in the non-overheated area does not exceed the first preset temperature t1. If the temperature of each electrode unit 33 in the non-overheated area does not exceed the first preset temperature t1, execute step 839. When the temperature of any electrode unit 33 in the non-overheated area exceeds the first preset temperature t1, step 840 is executed;

[0258] Step 839: Continue to apply alternating current signals to each electrode unit 33 in the non-overheated area by increasing the voltage or current amplitude of the currently applied alternating current signal and return to step 812;

[0259] Step 840: Determine whether the temperature of each electrode unit 33 in the non-overheated area does not exceed the second preset temperature t2. When the temperature of each electrode unit 33 in the non-overheated area does not exceed the second preset temperature t2, step 841 is executed. When the temperature of any electrode unit 33 in the non-overheated area exceeds the second preset temperature t2, step 842 is executed;

[0260] Step 841: Continue to apply alternating current signals to each electrode unit 33 in the non-overheated area while keeping the voltage or current amplitude of the currently applied alternating current signal unchanged and return to step 812;

[0261] Step 842: Determine whether the temperature of each electrode unit 33 in the obtained non-overheated area does not exceed the third preset temperature t3. If the temperature of each electrode unit 33 in the non-overheated area does not exceed the third preset temperature t3, execute step 843. If any of the electrode units 33 in the non-overheated area exceeds the third preset temperature t3, execute step 844.

[0262] Step 843: Continue to apply alternating current signals to each electrode unit 33 in the non-overheated area by reducing the voltage or current amplitude of the currently applied alternating current signal and return to step 812.

[0263] Step 844: Determine whether the temperature of each electrode unit 33 in the obtained non-overheated area does not exceed the preset temperature threshold t0. If the temperature of each electrode unit 33 in the non-overheated area does not exceed the preset temperature threshold t0, execute step 845.When the temperature of each electrode unit 33 in the non-overheated area exceeds the preset temperature threshold t0, return to step 821;

[0264] Step 845: Continue to apply alternating current signals to each electrode unit 33 in the non-overheated area in a manner that further reduces the voltage or current amplitude of the currently applied alternating current signal and return to step 812.

[0265] Specifically, the process of combining the control switches 54 and bidirectional switching switches 55 electrically connected to the corresponding electrode plates 13 in step 811 to apply alternating electrical signals to each electrode unit 33 of the electrode plate is as follows:

[0266] Disconnect all control switches 54 electrically connected to the corresponding electrode plates 13, and simultaneously switch all bidirectional switching switches 55 electrically connected to the corresponding electrode plates 13 to the end that applies alternating electrical signals to each electrode unit 33; or

[0267] Disconnect all control switches 54 electrically connected to the corresponding electrode plates 13, and simultaneously switch all bidirectional switching switches 55 electrically connected to the corresponding electrode plates 13 to the end that connects each electrode unit 33 to the alternating power line 57; or

[0268] Disconnect all control switches 54 electrically connected to the corresponding electrode plates 13, and simultaneously switch all bidirectional switching switches 55 electrically connected to the corresponding electrode plates 13 to their respective signal input terminals 2. Instruction manual, pages 30 / 46, CN 121371480 A

[0269] The process of obtaining the temperature of each electrode unit 33 of the electrode plate 13 in steps 812, 824, and 835 is specifically as follows:

[0270] Control the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch all of its end that applies alternating electrical signals to each electrode unit 33 to its end that collects temperature data from each electrode unit 33, and sequentially close the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode plate 13 to obtain the temperature of each electrode unit 33 of the electrode plate 13; or

[0271] Control the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch all of its signal input terminal 2 that applies alternating electrical signals to each electrode unit 33 to its signal acquisition terminal 1, and sequentially close the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode plate 13 to obtain the temperature of each electrode unit 33; The control switch 54, electrically connected to the corresponding temperature detection unit 35, acquires the temperature of each electrode unit 33 of the electrode plate 13; or

[0272] the bidirectional switching switch 55 electrically connected to the electrode plate 13 is controlled to switch the electrode plate 13 from being electrically connected to the alternating power line 57 to being electrically connected to the temperature detection unit 35 corresponding to each electrode unit 33 and the corresponding analog-to-digital converter 53, and the control switch 54 electrically connected to the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode plate 13 is closed sequentially in a time-sharing manner to acquire the temperature of each electrode unit 33 of the electrode plate 13; or

[0273] The bidirectional switching switch 55 electrically connected to the electrode plate 13 is controlled to switch each electrode unit 33 of the electrode plate 13 from transmitting alternating electrical signals to transmitting direct current signals or temperature detection signals from the corresponding temperature detection unit 35. The control switch 54 electrically connected to the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode plate 13 is closed sequentially in a time-sharing manner to obtain the temperature of each electrode unit 33 of the electrode plate 13.

[0274] The first preset temperature in steps 813, 825, 828, 836, and 838 is 40℃-40.3℃, preferably 40.2℃. In steps 815, 830, and 840, the second preset temperature is 40.4°C to 40.6°C, preferably 40.5°C; in steps 817, 832, and 842, the third preset temperature is 40.7°C to 40.9°C, preferably 40.8°C; in steps 819 and 844, the preset temperature threshold is 41°C to 41.5°C, preferably 41°C; and in step 822, the preset quantity threshold is preferably 2.

[0275] The process of continuing to apply the alternating electrical signal as described in steps 814, 816, 818, 820, 829, 831, 833, 834, 839, 841, 843, and 845 is specifically as follows:

[0276] Disconnect the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied, and simultaneously control the bidirectional switching switch 55 electrically connected to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied to conduct the alternating electrical signal transmission path electrically connected to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied to, thereby continuing to apply the alternating electrical signal to the electrode unit 33 to which the alternating electrical signal needs to be continuously applied; or

[0277] The control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 that needs to continue applying alternating electrical signals is disconnected, and at the same time, the bidirectional switching switch 55 electrically connected to the electrode unit 33 that needs to continue applying alternating electrical signals is switched from its respective signal acquisition terminal 1 to its respective signal input terminal 2, so as to continue applying alternating electrical signals to the electrode unit 33 that needs to continue applying alternating electrical signals; or

[0278] The control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 that needs to continue applying alternating electrical signals is disconnected, and at the same time, the bidirectional switching switch 55 electrically connected to the electrode unit 33 that needs to continue applying alternating electrical signals is electrically connected to the alternating power supply line 57, so as to continue applying alternating electrical signals to the electrode unit 33 that needs to continue applying alternating electrical signals; or

[0279] The control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 that needs to continue applying alternating electrical signals is disconnected, and at the same time, the bidirectional switching switch 55 electrically connected to the electrode unit 33 that needs to continue applying alternating electrical signals is switched from its respective signal acquisition terminal 1 to its respective signal input terminal 2, so as to continue applying alternating electrical signals to the electrode unit 33; or

[0279] The control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 that needs to continue applying alternating electrical signals is disconnected, and at the same time, the bidirectional switching switch 55 electrically connected to the electrode unit 33 that needs to continue applying alternating electrical signals is switched to the alternating power supply line 57, so as to continue applying alternating electrical signals to the electrode unit 33; or

[0279] The bidirectional switching switch 55 electrically connected to the electrode unit 33 that needs to continue applying alternating electrical signals is switched to the alternating power supply line 57Each of its respective signal input terminals 2 is closed and signal acquisition terminal 1 is disconnected, thereby continuing to apply alternating electrical signals to the electrode unit 33 that needs to continue to apply alternating electrical signals (page 35, CN 121371480 A, manual 31 / 46); or

[0280] disconnect the control switch 54 electrically connected to the temperature detection unit 35 corresponding to the electrode unit 33 that needs to continue to apply alternating electrical signals, and simultaneously control the bidirectional switching switch 55 electrically connected to the electrode unit 33 that needs to continue to apply alternating electrical signals so that the electrode unit 33 that needs to continue to apply alternating electrical signals switches from transmitting temperature detection signals to applying alternating electrical signals.

[0281] The method of increasing the voltage or current amplitude of the currently applied alternating electrical signal in steps 814, 829, and 839 to continue applying alternating electrical signals specifically means boosting the currently applied alternating electrical signal by a DC voltage amplitude increment of 0.03V per second before continuing to apply alternating electrical signals.

[0282] The method of continuing to apply the alternating current signal by reducing the voltage or current amplitude of the currently applied alternating current signal as described in steps 818, 820, 833, 834, 843 and 845 is to continue applying the alternating current signal by reducing the voltage or current amplitude of the currently applied alternating current signal by 5V and continuing for 3 minutes.

[0283] The process of stopping the application of alternating electrical signals to each electrode unit 33 of the electrode plate 13 in step 823 specifically includes:

[0284] Controlling the bidirectional switching switch 55 electrically connected to the electrode plate 13 to disconnect the electrical connection between each electrode unit 33 of the electrode plate 13 and the alternating power line 57; or

[0285] Controlling the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch all of its terminals that apply alternating electrical signals to each electrode unit 33 to its terminals that collect temperature data from each electrode unit 33; or

[0286] Controlling the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch all of its signal input terminals 2 that apply alternating electrical signals to each electrode unit 33 to its signal acquisition terminals 1; or

[0287] Controlling the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch the electrode plate 13 from the electrical connection between each electrode unit 33 and the alternating power line 57 to the temperature detection unit 35 and the corresponding analog-to-digital converter 53 corresponding to each electrode unit 33. Electrical connection; or

[0288] Controlling the bidirectional switching switch 55 electrically connected to the electrode plate 13 to switch each electrode unit 33 of the electrode plate 13 from transmitting alternating electrical signals to transmitting DC electrical signals or temperature detection signals from the corresponding temperature detection unit 35.

[0289] The process of stopping the application of alternating electrical signals to each electrode unit 33 in the over-temperature region described in step 827 is specifically as follows:

[0290] Controlling the bidirectional switching switch 55 electrically connected to each electrode unit 33 in the over-temperature region to disconnect the electrical connection between each electrode unit 33 in the over-temperature region and the alternating power supply line 57; or

[0291] The bidirectional switching switch 55 electrically connected to each electrode unit 33 in the over-temperature zone is switched from the end where it applies alternating electrical signals to each electrode unit 33 in the over-temperature zone to the end where it collects temperature data; or

[0292] The bidirectional switching switch 55 electrically connected to each electrode unit 33 in the over-temperature zone is switched from the signal input terminal 2 where it applies alternating electrical signals to each electrode unit 33 in the over-temperature zone to its signal acquisition terminal 1; or

[0293] The bidirectional switching switch 55 electrically connected to each electrode unit 33 in the over-temperature zone switches each electrode unit 33 in the over-temperature zone from being electrically connected to the alternating power line 57 to being electrically connected to its corresponding temperature detection unit 35 and its corresponding analog-to-digital converter 53; or

[0294] The bidirectional switching switch 55 electrically connected to each electrode unit 33 in the over-temperature zone switches each electrode unit 33 in the over-temperature zone from transmitting alternating electrical signals to transmitting DC electrical signals or temperature detection signals by its corresponding temperature detection unit 35.

[0295] When the tumor electric field therapy system 100 is in the standby state before starting work, no alternating electrical signal is applied to the electrode unit 33. The first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controls the bidirectional switching switch 55 (55-1 to 55-5) to switch to the signal acquisition terminal 1, and the control switches 54 (54-1 to 54-4) are turned on in sequence. The ADC unit 52 receives the temperature detection signal of the temperature detection unit 35 corresponding to each row of electrode units 33 (33-1 to 33-20) in sequence.

[0296] When control switch 54-1 is on, control switches (54-2, 54-3, 54-4) are all off, and bidirectional switches (55-1 to 55-5) are all set to signal acquisition terminal 1, ADC unit 52 receives temperature detection signals from temperature detection units 35 corresponding to electrode units (33-1 to 33-5);

[0297] When control switch 54-2 is on, control switches (54-1, 54-3, 54-4) are all off, and bidirectional switches (55-1 to 55-5) are all set to signal acquisition terminal 1, ADC unit 52 receives temperature detection signals from temperature detection units 35 corresponding to electrode units (33-6 to 33-10);

[0298] When control switch 54-3 is on, control switches (54-1, 54-2, 54-4) are all off, and bidirectional switches (55-1 to 55-5) are all set to signal acquisition terminal 1, ADC unit 52 receives temperature detection signals from temperature detection units 35 corresponding to electrode units (33-11 to 33-15);

[0299] When control switch 54-4 is on, control switches (54-1, 54-2, 54-3) are all off, and bidirectional switches (55-1 to 55-5) are all set to signal acquisition terminal 1, ADC unit 52 receives temperature detection signals from temperature detection units 35 corresponding to electrode units (33-11 to 33-15);When (55-1 to 55-5) are all placed at signal acquisition terminal 1, ADC unit 52 receives temperature detection signals from temperature detection units 35 corresponding to electrode units (33-16 to 33-20).

[0300] First controller 51 receives temperature detection signals from temperature detection units 35 corresponding to each electrode unit 33 (33-1 to 33-20) through ADC unit 52, and transmits them to AC signal generator 39 of electric field generator 30 through first communication unit 56 and second communication unit 38, and then controls or adjusts the alternating electrical signals applied to each electrode unit 33 through second controller 37.

[0301] Although the various operations are depicted in the drawings in a specific order, this should not be construed as requiring that these operations must be performed in the specific order shown or in chronological order, nor should it be construed as requiring that all the operations shown must be performed to obtain the desired result.

[0302] Example 2:

[0303] The main concept of the tumor electric field therapy system 100 described above is that both the adapter 20 and the electric field generator 30 are equipped with an alternating power supply line 57 to control the synchronous change of the alternating electrical signal of all electrode units 33 on an electrode plate 13, such as the voltage or current rising or falling at the same time. However, it cannot simultaneously apply different alternating electrical signals, such as different voltages or currents, to different groups of electrode units 33. Referring to Figures 17 to 20, another tumor electric field therapy system 100' is described below. Its main concept is the same as the tumor electric field therapy system 100 described above. The difference is that: in this tumor electric field therapy system 100', the adapter 20' and the electric field generator 30' are equipped with a corresponding alternating power supply line 57' for each group of electrode units 33' on the corresponding electrode plate 13', so that different alternating electrical signals, such as different voltages or currents, can be applied to different groups of electrode units 33' at the same time.

[0304] Figure 18 is a schematic diagram of the circuit connection of an electrode 13', an adapter 20', and an electric field generator 30' in another tumor electric field therapy system 100' according to an embodiment of this application. The tumor electric field therapy system 100' includes: at least one pair of electrode 13', an adapter 20' connected to the electrode 13', and an electric field generator 30' connected to the adapter 20'.

[0305] The specific structure of the electrode 13' is the same as that of the electrode 13 described above, and will not be repeated here.

[0306] The specific structure of the adapter 20' is similar to that of the adapter 20 described above, except that: referring to Figures 18 and 19, each electrode piece 13' in the adapter 20' is provided with 5 AC power lines 57', and the 5 AC power lines 57' are arranged one-to-one with the 5 column electrode units 33' of each electrode piece 13'. Each electrode piece 13' is provided with a corresponding bidirectional switching switch 55' and a grounding switch 54'. The signal input terminal 2 of the bidirectional switching switch 55' is electrically connected to a separate AC power line.57', so that the tumor electric field therapy system 100' can simultaneously apply different alternating electrical signals, such as different voltages or currents, to different column groups of electrode units in each electrode sheet 13' as needed.

[0307] The specific structure of the electric field generator 30' is similar to that of the electric field generator 30 described above, except that: referring to Figures 18 and 20, a power supply switch 40' is provided for each alternating power line 57' between the AC signal generator 39' and the adapter 20', so as to individually control the on / off of the alternating electrical signal for each column group of electrode units 33' of each electrode sheet 13'.

[0308] Specifically, referring to Figures 18 and 19, the adapter 20' includes: a first controller 51', multiple sets of ADC units 52' connected to the first controller 51', multiple sets of voltage-reducing resistors 53' and multiple sets of control switches 54' corresponding to the multiple sets of ADC units 52', multiple sets of bidirectional switching switches 55' connected to the multiple sets of ADC units 52', a first communication unit 56', multiple alternating power lines 57' connected to each set of bidirectional switching switches 55', and a first power module 58' connected to the first communication unit 56', the first controller 51', and the multiple sets of ADC units 52'. The first power module 58' provides DC power VCC to each electronic component of the adapter 20'. The adapter 20' also includes multiple circuit lines (unlabeled), which are electrically connected one-to-one to the multiple grounding lines 18' and multiple dual-purpose signal lines 19' in the substrate 31' of the corresponding electrode 13' via the first cable 15' of the corresponding electrode 13'. The multiple circuit lines (unlabeled) include multiple different alternating power supply lines 57' that transmit alternating electrical signals to the corresponding electrode 13' and are electrically connected to the multiple dual-purpose signal lines 19' in the substrate 31' of the corresponding electrode 13'; multiple circuit lines (unlabeled) that are electrically connected one-to-one to the multiple dual-purpose signal lines 19' in the substrate 31' of the corresponding electrode 13' and are used to power each temperature detection unit 35' of the electrode 13' or transmit the temperature detection signal of the electrode 13'; and multiple circuit lines (unlabeled) that are electrically connected one-to-one to the multiple grounding lines 18' in the substrate 31' of the corresponding electrode 13'. The number L of circuit lines electrically connecting adapter 20' to one electrode piece 13' is equal to the sum of the number of rows and columns of electrode units 33' of electrode piece 13'; the number H of circuit lines electrically connecting adapter 20' to X electrode pieces 13' is equal to X times the number of circuit lines electrically connecting it to a single electrode piece 13', that is, H = XL = X × (M + N). The number of groups of control switches 54' and the number of groups of bidirectional switching switches 55' are both related to the number of electrode pieces 13'. The number of groups of control switches 54'The number of groups of control switches 54' is the same as the number of groups of bidirectional switching switches 55', and is not less than the number of electrode plates 13'. Optionally, the number of groups of control switches 54' and bidirectional switching switches 55' is the same as the number of electrode plates 13'.

[0309] For example, each group of control switches 54' is provided with multiple control switches 54', and the multiple control switches 54' are respectively connected to the adapter 20' and electrically connected to the circuit lines (unlabeled) corresponding one-to-one with the multiple grounding wires 18' of the corresponding electrode plate 13', and are configured to control the conduction or disconnection of the multiple grounding wires 18'. The circuit lines (unlabeled) that are electrically connected one-to-one with the multiple grounding wires 18' of the electrode plate 13' are grounded at the end near the control switch 54'. The number of control switches 54' in each group of control switches 54' is related to the number of grounding wires 18' of the corresponding electrode plate 13' substrate 31', and in this embodiment, the two are equal. As shown in Figure 18, in this embodiment, the multiple control switches 54' are respectively the first control switch 54-1', the second control switch 54-2', the third control switch 54-3', and the fourth control switch 54-4'. Each of the multiple control switches 54' in the same group controls the opening or closing of the corresponding grounding wire 18' of the same electrode piece 13'. The first control switch 54-1' is used to control the opening or closing of the first grounding wire 18-1' of the corresponding electrode piece 13', and can then cooperate with the corresponding group of bidirectional switching switches 55' to control the energization and de-energization of the temperature detection units 35' corresponding to the five electrode units 33' in the first row group 33 of the electrode piece 13'; the second control switch 54-2' is used to control the opening or closing of the second grounding wire 18-2' of the electrode piece 13', and can then cooperate with the corresponding group of bidirectional switching switches 55' to control the energization and de-energization of the electrode piece 13'. The temperature detection units 35' corresponding to the five electrode units 33' in the second row group 33' are energized and de-energized; the third control switch 54-3' is used to control the closing or opening of the third grounding wire 18-3' of the electrode plate 13', and can cooperate with the corresponding bidirectional switching switch 55' to control the energization and de-energization of the temperature detection units 35' corresponding to the five electrode units 33' in the third row group 33' of the electrode plate 13'; the fourth specification 34 / 46 pages 38 CN 121371480 A The control switch 54-4' is used to control the opening or closing of the fourth grounding wire 18-4' of the electrode plate 13', and can then cooperate with the corresponding bidirectional switching switch 55' to control the energization and de-energization of the temperature detection units 35' corresponding to the five electrode units 33' in the fourth row group 33' of the electrode plate 13'. The control switch 54' can be...Mechanical switches, such as relays. Control switches 54' can also be electronic switches, and each control switch 54' can be opened and closed by an additional first controller 51'.

[0310] In this embodiment, multiple sets of control switches 54' are all electronic switches. The first controller 51' is communicatively connected to multiple sets of control switches 54' and is used to sequentially and cyclically control the opening and closing states of multiple control switches 54' in each set of control switches 54', thereby sequentially and individually turning on each grounding wire 18' of the corresponding electrode 13' and cooperating with the switching of the corresponding bidirectional switching switch 55' to collect the temperature of the patient's body surface detected by all temperature detection units 35' on the electrode 13'. The number of each set of control switches 54' is not less than the number of grounding wires 18' of the substrate 31' of the corresponding electrode 13'. In this embodiment, the number of each set of control switches 54' is the same as the number of grounding wires 18' of the corresponding electrode 13'.

[0311] Each group of bidirectional switching switches 55' is provided with multiple bidirectional switching switches 55'. The multiple bidirectional switching switches 55' in each group are respectively connected to the adapter 20' and electrically connected to the circuit lines (unlabeled) that correspond one-to-one with the multi-purpose signal lines 19' of the corresponding electrode piece 13'. The number of bidirectional switching switches 55' in each group of bidirectional switching switches 55' is related to the number of dual-purpose signal lines 19' of the substrate 31' of the corresponding electrode piece 13', which is greater than or equal to the number of dual-purpose signal lines 19' of the substrate 31' of the corresponding electrode piece 13'. In this embodiment, the two are equal. Each bidirectional switch 55' has two ends labeled 1 and 2. The signal acquisition terminals 1 of multiple bidirectional switches 55' in the same group are electrically connected to the corresponding detection channels of multiple detection channels of the corresponding group of ADC units 52' through temperature sampling points (unlabeled). The signal input terminal 2 of each bidirectional switch 55' in the same group is electrically connected to the corresponding different alternating power lines 57' and is configured to control the multi-channel dual-purpose signal line 19' to connect to the corresponding different alternating power lines 57' to transmit alternating electrical signals or to connect to the corresponding detection channel of the corresponding group of ADC units 52' to receive the temperature detection signal output by the temperature detection unit 35'.

[0312] As shown in FIG18, taking the electrical connection of an electrode plate 13' with an adapter 20' as an example, in this embodiment with 20 electrode units 33', the multiple bidirectional switching switches 55' are respectively a first bidirectional switching switch 55-1', a second bidirectional switching switch 55-2', a third bidirectional switching switch 55-3', a fourth bidirectional switching switch 55-4', and a fifth bidirectional switching switch 55-5'. The multiple bidirectional switching switches 55' in the same group control the switching of a corresponding dual-purpose signal line 19' in the same electrode plate 13' between transmitting alternating electrical signals and transmitting temperature detection signals. Specifically, the first bidirectional switching switch55-1' is used to control the switching between the alternating electrical signal output from the alternating power supply line 57-1' and the temperature detection signal of the corresponding electrode 13', thereby controlling the switching between the conduction of each electrode unit 33' of the first column group of electrode units 33-1', 33-6', 33-11', and 33-16' and the conduction of the signal terminal 35-2' of each temperature detection unit 35' corresponding to the electrode units 33-1', 33-6', 33-11', and 33-16' in the first column group of electrode 13', and cooperating with the corresponding control switches 54-1', 54-2', 54-3', and 54-4', so that the first column of electrode units 33-1', 33-6', 33-11', and 33-16', and the corresponding temperature detection units 35' in the first column group of electrode units 33-1', 33-6', 33-11', and 33-16', are connected to the first column of electrode units 33-1', 33-16', 33-1 ... 6', Electrode units 33-11' and 33-16' transmit individual alternating electrical signals to the patient or output temperature detection signals collected by the temperature detection units 35' corresponding to these electrode units 33' to the corresponding ADC unit 52'; the second bidirectional switch 55-2' is used to control the switching of the second dual-purpose signal line 19-2' of the corresponding electrode 13' between the alternating electrical signal output from the alternating power supply line 57-2' and the temperature detection signal, thereby controlling the conduction of each electrode unit 33' of the second column group of electrode units 33-2', 33-7', 33-12', and 33-17' in the second column group of electrode units 33-2', 33-7', 33-12', and 33-17' and the corresponding temperature detection signals of each electrode unit 33' in the second column group of electrode units 33-2', 33-7', 33-12', and 33-17'. (Instruction manual, pages 35 / 46, 39, CN 121371480 A) The signal terminal 35-2' of the temperature detection unit 35' enables the switching between the two and cooperates with the corresponding control switches 54-1', 54-2', 54-3', and 54-4' to enable the second row of electrode units 33-2', 33-7', 33-12', and 33-17' to transmit individual alternating electrical signals to the patient or output temperature detection signals collected by the temperature detection unit 35' corresponding to these electrode units 33' to the corresponding ADC unit 52'; the third bidirectional switching switch 55-3' is used to control the third dual-purpose signal line 19- of the corresponding electrode pad 13'. 3' switches between the alternating electrical signal output from the alternating power line 57-3' and the temperature detection signal, thereby controlling the conduction of each electrode unit 33' in the third column group of electrode units 33-3', 33-8', 33-13', and 33-18', and the corresponding temperature detection signals in the third column group of electrode units 33-3', 33-8', 33-13', and 33-18'.The signal terminal 35-2' of electrode 33' enables the switching between the two and cooperates with the corresponding control switches 54-1', 54-2', 54-3', and 54-4' to enable the third column of electrode units 33-3', 33-8', 33-13', and 33-18' to transmit individual alternating electrical signals to the patient or output temperature detection signals collected by the temperature detection units 35' corresponding to these electrode units 33' to the corresponding ADC unit 52'; the fourth bidirectional switch 55-4' is used for control The fourth dual-purpose signal line 19-4' of the corresponding electrode 13' switches between the alternating electrical signal output from the alternating power supply line 57-4' and the temperature detection signal, thereby controlling the conduction of each electrode unit 33' in the fourth column group of electrode units 33-4', 33-9', 33-14', and 33-19', and the corresponding temperature detection units 35' in the fourth column group of electrode units 33-4', 33-9', 33-14', and 33-19'. The signal terminal 35-2' enables the switching between the two and cooperates with the corresponding control switches 54-1', 54-2', 54-3', and 54-4' to enable the fourth column of electrode units 33-4', 33-9', 33-14', and 33-19' to transmit individual alternating electrical signals to the patient or output temperature detection signals collected by the temperature detection units 35' corresponding to these electrode units 33' to the corresponding ADC unit 52'; the fifth bidirectional switching switch 55-5' is used to control the switching of the fifth dual-purpose signal line 19-5' of the corresponding electrode piece 13' between the alternating electrical signal output from the alternating power supply line 57-5' and the temperature detection signal, thereby controlling the electrode units 33-5', 33-14', and 33-19' in the fifth column of the electrode piece 13'. 10', 33-15', and 33-20' are switched between their conduction and the signal terminals 35-2' of the temperature detection units 35' corresponding to the electrode units 33-5', 33-10', 33-15', and 33-20' in the fifth column group. This switching, along with the corresponding control switches 54-1', 54-2', 54-3', and 54-4', allows the fifth column of electrode units 33-5', 33-10', 33-15', and 33-20' to transmit individual alternating electrical signals to the patient or output temperature detection signals collected by the temperature detection units 35' corresponding to these electrode units 33' to the corresponding ADC unit 52'. When the signal input terminal 2' of each group of bidirectional switching switches 55' is switched...When the signal acquisition terminal 1 is disconnected, alternating electrical signals can be transmitted to each electrode unit 33' of each column group of the corresponding electrode plate 13' through different alternating power lines 57'. When the signal acquisition terminal 1 of each group of bidirectional switching switches 55' is turned on and the signal input terminal 2 is turned off, it can cooperate with each control switch 54' in the corresponding group of control switches 54' to transmit the temperature detection signals collected by the temperature detection unit 35' corresponding to each electrode unit 33' on the electrode plate 13' in a time-division manner. The bidirectional switching switch 55' can be a mechanical switch, such as a relay. The bidirectional switching switch 55' can also be an electronic switch, and each bidirectional switching switch 55' can be switched by an additional first controller 51'.

[0313] In this embodiment, all groups of bidirectional switching switches 55' are electronic switches. The first controller 51' is communicatively connected to multiple sets of bidirectional switching switches 55', and is used to control the switching of multiple bidirectional switching switches 55' in each set of bidirectional switching switches 55' between their respective signal acquisition terminals 1 and signal input terminals 2, and cooperate with the closing or opening of the corresponding control switch 54' to continuously monitor the temperature of the patient's body surface detected by all temperature detection units 35' on the electrode 13' or transmit alternating electrical signals to the patient. Specification 36 / 46 pages 40 CN 121371480 A

[0314] In this embodiment, each set of ADC units 52' is electrically connected to the signal acquisition terminals 1 of multiple bidirectional switching switches 55' in the corresponding set of bidirectional switching switches 55' through multiple circuit lines (unlabeled) in the adapter 20', and is configured to receive the temperature detection signal transmitted by the multi-channel dual-purpose signal line 19' of the corresponding electrode 13', and convert the temperature detection signal from analog signal to digital signal. Each ADC unit 52' includes multiple detection channels A, B, C, D, and E. Each detection channel A, B, C, D, and E is used to connect to a corresponding dual-purpose signal line 19' in the multi-channel dual-purpose signal line 19' via a corresponding bidirectional switch 55'. As shown in Figure 18, each ADC unit 52' contains a total of 5 detection channels A, B, C, D, and E, which are respectively the first detection channel A, the second detection channel B, the third detection channel C, the fourth detection channel D, and the fifth detection channel E. The first detection channel A is connected to the first dual-purpose signal line 19-1' via the signal acquisition terminal 1 of the first bidirectional switch 55-1', the second detection channel B is connected to the second dual-purpose signal line 19-2' via the signal acquisition terminal 1 of the second bidirectional switch 55-2', the third detection channel C is connected to the third dual-purpose signal line 19-3' via the signal acquisition terminal 1 of the third bidirectional switch 55-3', the fourth detection channel D is connected to the fourth dual-purpose signal line 19-4' via the signal acquisition terminal 1 of the fourth bidirectional switch 55-4', and the fifth detection channel E is connected to the first dual-purpose signal line 19-4' via the signal acquisition terminal 1 of the second bidirectional switch 55-2'.The signal acquisition terminal 1 of the five bidirectional switching switch 55-5' is connected to the fifth dual-purpose signal line 19-5'. Each detection channel A, B, C, D, and E is used to receive the temperature detection signal collected by the temperature detection unit 35' corresponding to the electrode unit 33' connected to the corresponding dual-purpose signal line 19'. In addition, each detection channel A, B, C, D, and E is connected to the first power module 58', which provides detection voltage to the detection channel A, B, C, D, and E, via a corresponding voltage divider resistor 53' in the adapter 20'. The first power module 58' provides DC power.

[0315] In this embodiment, the first communication unit 56' is configured to acquire the digital signals output by multiple ADC units 52' and send the digital signals to the electric field generator 30'. The electric field generator 30' is also configured to control and adjust the voltage of the alternating electrical signal provided to the multiple electrode units 33' of the electrode sheet 13' according to the received digital signal. For example, when any of the received digital signals exceeds a preset threshold, it indicates that the temperature detected by the temperature detection unit 35' corresponding to at least one electrode unit 33' in the electrode sheet 13' exceeds the preset threshold temperature (e.g., 41°C, 42°C, etc.). At this time, the voltage of the alternating electrical signal output by the electric field generator 30' can be appropriately reduced or stopped to avoid the electrode unit 33' of the electrode sheet 13' from becoming too hot when the alternating electrical signal is applied, causing low-temperature burns to the patient's skin. The preset threshold temperature and the preset threshold can be determined according to the human safety threshold. The first communication unit 56' is controlled by the first controller 51' and serially transmits the digital signals converted by multiple ADC units 52'. In this embodiment, the preset threshold temperature can be a value within the range of 36°C to 45°C.

[0316] Referring to FIG18, in this embodiment, the first power module 58' is electrically connected to the second power module 32' of the electric field generator 30' and is configured to supply power to the first controller 51', multiple ADC units 52', and the first communication unit 56' of the adapter 20'. Each electrode 13' is connected to the adapter 20' via a first connector 60', which is adapted to connect the corresponding electrode 13' to the adapter 20'. A second connector 70' is provided between the adapter 20' and the electric field generator 30', which is adapted to connect the electric field generator 30' to the adapter 20'. The adapter 20' also includes a second cable 25' connected to the second connector 70'. The second connector 70' includes a second plug 71' located at the end of the second cable 25' furthest from the first controller 51' and a second socket 72' located on the electric field generator 30'. The second plug 71' and the second socket 72' are push-button spring connectors, meaning the second connector 70' uses a plug-in method to connect the adapter 20' to the electric field generator.The first connector 60' is connected to the second connector 70' via a corresponding 5-channel AC power line 57'. The first connector 60', such as X1, Y1, X2 and Y2, is also connected to a corresponding set of control switches 54' and a corresponding set of ADC units 52'. Each first connector 60' is connected to the second connector 70' and the corresponding set of ADC units 52' via a corresponding set of bidirectional switching switches 55'. The second cable 25' has 8 wires, including 4 five-core wires 1 to 4 that are electrically connected to the corresponding 5 AC power lines 57' and used to transmit different AC signals, 1 wire 5 that is electrically connected to the data receiving line RX' of the first communication unit 56', 1 wire 6 that is electrically connected to the data transmitting line TX' of the first communication unit 56', 1 wire 7 that is electrically connected to the VCC power line of the first power module 58', and 1 wire 8 that is electrically connected to the GND line of the first power module 58'. The second connector 70' is connected to the first communication unit 56' via a data receiving line RX' and a data transmitting line TX'. The VCC pin of the second connector 70' is connected to the VVC power line of the first power module 58', and the GND pin of the second connector 70' is connected to the GND line of the first power module 58' and grounded. The VCC pin of the second connector 70' is also connected to the corresponding group voltage resistors 53' and the corresponding group ADC units 52' via the VCC power line of the first power module 58'.

[0317] Referring to Figures 18 and 20, the electric field generator 30' includes: a second power module 32', a second controller 37', an AC signal generator 39', a second communication unit 38', and multiple power supply switches 40'. The VCC pin of the second connector 70' is also electrically connected to the VCC power line of the second power module 32', and the GND pin of the second connector 70' is grounded via the GND line of the second power module 32'. The second power module 32' is also connected to and supplies power to the second controller 37' and the AC signal generator 39', respectively. The second communication unit 38' is electrically connected to the wire 5 of the second connector 70' via its data receiving line RX' and to the wire 6 of the second connector 70 via its data transmitting line TX', thereby realizing information interaction between the electric field generator 30' and the adapter 20'. The second controller 37' is also electrically connected to the second communication unit 38', the AC signal generator 39', and multiple sets of power supply switches 40'. The second controller 37' is configured to control the opening and closing of each power supply switch 40' in each set of power supply switches 40' according to the relevant digital signals received by the second communication unit 38' from the adapter 20'.The parameters of different alternating electrical signals applied by the AC signal generator 39 are adjusted. The AC signal generator 39 is electrically connected to the second connector 70' via multiple sets of power supply switches 40' and wires 1 to 4 that transmit different alternating electrical signals. Each set of power supply switches 40' includes multiple power supply switches 40', and the multiple sets of power supply switches 40' are arranged one-to-one with multiple electrode plates 13'. Each set of power supply switches 40' is electrically connected to the corresponding five-core wires 1, 2, 3, and 4 in the second connector 70' via a five-core AC power cable 41-1', 41-2', 41-3', and 41-4', and is also electrically connected to the corresponding electrode plate 13' via the corresponding five-core wires 1, 2, 3, and 4 in the second connector 70', so as to deliver different alternating electrical signals to each electrode plate 13. The AC signal generator 39' is electrically connected to the multiple sets of power supply switches 40' via a five-core AC power cable 41'. Specifically, the number of power supply switches 40' in the electric field generator 30' is related to the number of electrode plates 13'. In this embodiment, the number of power supply switches 40' is equal to the number of electrode plates 13', both being 4. The number of each power supply switch 40' is related to the number of columns of the corresponding electrode plates 13'. In this embodiment, the number of each power supply switch 40' is equal to the number of columns of the corresponding electrode plates 13', both being 5. The multiple power supply switches 40' include a first power supply switch 40-1', a second power supply switch 40-2', a third power supply switch 40-3', and a fourth power supply switch 40-4', which are electrically connected one-to-one with the five-core wires 1 to 4 of the second connector 70'. One end of the first group of power supply switches 40-1' is electrically connected to the AC signal generator 39' via the five-core AC power line 41' of the electric field generator 30', and the other end is electrically connected to the corresponding five-core wire 1 for transmitting alternating electrical signals in the second connection 70' via a five-core AC power line 41-1', and electrically connected to the five-way alternating power line 57' at port X1' of the adapter 20' via the five-core wire 1 of the second connector 70', the five-way alternating power line 57' at port X1' of the adapter 20' is electrically connected to the first connector 60', and the first connector 60' at port X1 of the adapter 20' is electrically connected to the corresponding electrode plate 13', so as to control whether the AC signal generator 39' supplies different alternating electrical signals to the electrode units 33' in the five columns of the electrode plate 13' corresponding to the five-way alternating power line 57' electrically connected to port X1 of the adapter 20'; the second group of power supply switches 40- One end of 2' is electrically connected to AC signal generator 39' via a five-core AC power supply line 41' of electric field generator 30', and the other end is electrically connected to the corresponding five-core wire 2 in the second connection 70' that transmits alternating electrical signals via a five-core AC power supply line 41-2'.The second connector 70' is electrically connected to the five-channel AC power line 57' at port Y1' of the adapter 20' via the five-core wire 2; the five-channel AC power line 57' at port Y1' of the adapter 20' is electrically connected to the first connector 60'; and the first connector 60' at port Y1' of the adapter 20' is electrically connected to the corresponding electrode plate 13'. This controls whether the AC signal generator 39' transmits different alternating electrical signals to the electrode units 33' in the five columns of the electrode plate 13' corresponding to the five-channel AC power line 57' at port Y1' of the adapter 20'. One end of the third power supply switch 40-3' is electrically connected to the AC signal generator 39' via the five-core AC power line 41' of the electric field generator 30', and the other end is connected via a five-core AC power line 41-3'. The five-core wire 3' corresponding to the alternating current signal in the second connection 70' is electrically connected to the five-channel alternating power line 57' located at port X2' of the adapter 20' via the five-core wire 3' of the second connector 70'. The five-channel alternating power line 57' located at port X2' of the adapter 20' is electrically connected to the first connector 60'. The first connector 60' located at port X2' of the adapter 20' is electrically connected to the corresponding electrode plate 13' to control whether the AC signal generator 39' transmits the signal to the electrode plate 13' corresponding to the five-channel alternating current signal in the adapter 20'. The electrode units 33' in the five columns of the source line 57' transmit different alternating electrical signals; one end of the fourth group of power supply switches 40-4' is electrically connected to the AC signal generator 39' through the five-core AC power line 41' of the electric field generator 30', and the other end is electrically connected to the corresponding five-core wire 4' transmitting alternating electrical signals in the second connection 70' through a five-core AC power line 41-4', and is electrically connected to the five-channel alternating power line 57' located at port Y2' of the adapter 20' through the five-core wire 4 of the second connector 70'. The five-channel alternating power line 57' of the adapter 20' located at port Y2' The first connector 60', which is electrically connected to the first connector 60' and located at port Y2' of the adapter 20', is electrically connected to the corresponding electrode piece 13' to control whether the AC signal generator 39' supplies different alternating electrical signals to the electrode units 33' in the five columns of the electrode pieces 13' electrically connected to port Y1' of the adapter 20', corresponding to the five alternating power lines 57'.

[0318] The working principle of the tumor electric field therapy system 100' of this embodiment will be described in detail below with reference to Figures 18 to 20.

[0319] It should be noted that the working principle of temperature acquisition in the tumor electric field therapy system 100' is the same as that of temperature acquisition in the tumor electric field therapy system 100, and will not be repeated here.

[0320] The working principle of applying alternating electrical signals to the tumor electric field therapy system 100' is similar to that of applying alternating electrical signals to the tumor electric field therapy system 100. The difference is that this embodiment can apply different alternating electrical signals to electrode units 33 in different columns at the same time, which is more flexible.

[0321] Specifically, when it is necessary to apply alternating electrical signals to each electrode unit 33' of a certain electrode plate 13', the first controller 51' of the adapter 20' or the second controller 37' of the electric field generator 30' controls the signal input terminal 2 of each of the multiple bidirectional switching switches 55' electrically connected to the electrode plate 13' to be turned on and the signal acquisition terminal 1 to be turned off, and controls a set of power supply switches 40' electrically connected to the electrode plate 13' to be turned on. At this time, the second controller 37' of the electric field generator 30' controls the AC signal generator 39' to apply different alternating electrical signals to each column of electrode units 33' of the electrode plate 13' through different alternating power lines 57', and the magnitude of the voltage or current of the different alternating electrical signals applied can be adjusted. That is, the switching unit (unlabeled) is configured to switch the dual-purpose signal lines 19 corresponding to at least two column groups to different alternating power lines 57', so that each electrode unit 33 of each column group is applied with different alternating electrical signals based on different alternating power lines 57'.

[0322] It should be noted that, in some other embodiments, a set of bidirectional switching switches 55' electrically connected to a certain electrode piece 13' can also be controlled by the first controller 51' of the adapter 20' or the second controller 37' of the electric field generator 30' to apply different alternating electrical signals to some electrode units 33' of the electrode piece 13' in the same time period. For example, the first controller 51' of the adapter 20' or the second controller 37' of the electric field generator 30' controls the signal input terminal 2 of the first bidirectional switch 55-1' of a set of bidirectional switches 55' electrically connected to the electrode 13' to be turned on and the signal acquisition terminal 1 to be turned off. It also controls the one power supply switch 40' corresponding to the first bidirectional switch 55-1' of a set of power supply switches 40' electrically connected to the electrode 13' to be turned on. At this time, the second controller 37' of the electric field generator 30' controls the AC signal generator 39' to apply alternating electrical signals to the first column of electrode units 33-1', 33-6', 33-11' and 33-16' of the electrode 13' through the corresponding alternating power supply line 57'. The voltage or current of the applied alternating electrical signal is adjustable. It should be noted that in some other embodiments, different alternating electrical signals can be applied simultaneously to two, three, or four rows of electrode units 33 within the same time period; details will not be elaborated here.

[0323] It should be noted that in this embodiment, the control switch 54', which is electrically connected to each of the multiple grounding lines 18' of the electrode plate 13', and the bidirectional switching switch 55', which is electrically connected to each of the multiple dual-purpose signal lines 19' of the electrode plate 13', are both located in the adapter 20'. However, in other embodiments, the control switch 54', which is electrically connected to the grounding line 18', and the bidirectional switching switch 55', which is electrically connected to the dual-purpose signal lines 19', may also be located on the electrode plate 13' or in the electric field generator 30', which will not be elaborated further here. In addition, the ADC unit 52' located in the adapter 20' may also be located in the electric field generator 30' and directly controlled by the second controller 37'.

[0324] The tumor electric field therapy system 100' of this application can achieve real-time and comprehensive temperature monitoring of all electrode units 33' on the electrode sheet 13' without increasing the weight of the electrode sheet 13' or the number of wire cores of the first cable 15' electrically connected to the electrode sheet 13'. It can then determine whether the electrode sheet 13' is qualified based on the obtained temperature detection signal; or determine whether the temperature detection unit 35' of the electrode sheet 13' is faulty or abnormal based on the obtained temperature detection signal, and determine whether the electrode sheet 13' needs to be replaced based on the number of faulty or abnormal temperature detection units 35'; or identify the electrode sheet type based on the obtained temperature detection signal if the electrode sheet 13' is qualified; or determine whether the electrode unit 33' of the electrode sheet 13' is overheated based on the obtained temperature detection signal if the electrode sheet 13' is qualified, and then control the alternating electrical signal applied to the electrode sheet 13' or the corresponding column of electrode units 33' of the electrode sheet 13', so as to avoid low-temperature burns to the patient's body surface during tumor treatment through the electrode sheet 13'. Furthermore, the substrate 31' of the electrode sheet 13' of this application is electrically connected to the signal terminals 35-2' of the same electrode unit 33' and its corresponding temperature detection unit 35' simultaneously via the same dual-purpose signal line 19'. This allows for the transmission of both alternating current signals and DC signals for temperature signal acquisition, along with the acquired temperature detection signals, via the dual-purpose signal line 19'. Simultaneously, it significantly reduces the number of conductive traces (grounding line 18', dual-purpose signal line 19') on the substrate 31', lowering the wiring complexity, simplifying the manufacturing process, reducing the weight of the substrate 31', and lowering manufacturing costs. The electrode sheet 13' of this application can also switch between applying alternating current signals for tumor treatment and transmitting DC signals for temperature acquisition and the acquired temperature detection signals through a combination of control switch 54' electrically connected to its grounding line 18' and bidirectional switching switch 55' electrically connected to the dual-purpose signal line 19'.

[0325] Specifically, when it is necessary to apply an alternating electrical signal to the patient through each electrode unit 33' of a certain electrode sheet 13',The first controller 51' of the adapter 20' or the second controller 37' of the electric field generator 30' controls all the control switches 54' in a set of control switches 54' corresponding to the electrode 13' to be turned off, and at the same time controls all the bidirectional switching switches 55' in a set of bidirectional switching switches 55' corresponding to the electrode 13' to be switched to their respective signal input terminals 2, so that the signal acquisition terminals 1 of these bidirectional switching switches 55' are all turned off and the signal input terminals 2 are all turned on, so that all the dual-purpose signal lines 19' of the electrode 13' are electrically connected to the adapter 20' and the corresponding multi-channel alternating power supply lines 57' of the electrode 13', thereby transmitting the same or different alternating electrical signals to each electrode unit 33' of the electrode 13'. When the temperature detection signals of the temperature detection units 35' corresponding to all electrode units 33' of the detected electrode plate 13' are much lower than the preset temperature threshold stored in the electric field generator 30' or the adapter 20', the electric field generator 30' controls the AC signal generator 39 to continue generating alternating electrical signals with increased voltage or current amplitude, or with constant voltage or current amplitude, through its second controller 37'. These signals are then transmitted to the corresponding counter electrode plate 13' through the corresponding multiple alternating power lines 57' of the adapter 20', so that the counter electrode plate 13' continues to receive alternating electrical signals. When the temperature detection signals of the temperature detection units 35' corresponding to all electrode units 33' of the detected electrode plate 13' are lower than but close to the preset temperature threshold stored in the electric field generator 30' or the adapter 20', the electric field generator 30' can reduce the voltage or current of the alternating electrical signals generated by the AC signal generator 39' through the second controller 37', thereby reducing the voltage or current applied to the electrode plate. (Pages 40 / 46 of this specification, CN 121371480 A) The alternating voltage or current on the electrode 13' is monitored. When the temperature detection signal of the temperature detection unit 35' corresponding to the electrode unit 33' of a certain electrode 13' is detected to be greater than a preset temperature threshold, the electric field generator 30' controls a set of power supply switches 40' electrically connected to the electrode 13' to disconnect via the second controller 37', thereby stopping the application of alternating voltage signals to the electrode 13'. Alternatively, the second controller 37' of the electric field generator 30' or the first controller 21' of the adapter 20' controls all bidirectional switching switches 55' electrically connected to the electrode 13' to switch from their signal input terminals 2 to signal acquisition terminals 1, that is, all bidirectional switching signal acquisition terminals 1 of all bidirectional switching switches 55' electrically connected to the electrode 13' are turned on and all signal input terminals 2 are disconnected, thereby stopping the application of alternating voltage signals to the electrode 13'. Or, when the temperature detection signal of the temperature detection unit 35' corresponding to the electrode unit 33' of a certain electrode 13' is detected to be greater than a preset temperature threshold, the electric field generator 30' controls a set of power supply switches 40' electrically connected to the electrode 13' to disconnect via the second controller 37', thereby stopping the application of alternating voltage signals to the electrode 13'.When the signal exceeds a preset temperature threshold, the second controller 37' of the electric field generator 30' controls a set of power supply switches 40' electrically connected to the electrode plate 13' to remain on, and the second controller 37' of the electric field generator 30' or the first controller 21' of the adapter 20' controls a bidirectional switching switch 55' electrically connected to the electrode unit 33' of the electrode plate 13' to switch from its signal input terminal 2 to its signal acquisition terminal 1, and the second controller 37' of the electric field generator 30' or the first controller 21' of the adapter 20'... Simultaneously, all other bidirectional switching switches 55' electrically connected to electrode units 33' whose temperature detection signals do not exceed a preset temperature threshold and are located in different columns from those electrode units 33' whose temperature detection signals exceed the preset temperature threshold remain electrically connected to their respective signal input terminals 2. This stops applying alternating electrical signals to all electrode units 33' in the same column as those electrode units 33' whose temperature detection signals exceed the preset temperature threshold, and continues applying alternating electrical signals to the remaining columns of electrode units 33' whose temperature detection signals do not exceed the preset temperature threshold. The alternating electrical signals applied to the remaining columns of electrode units 33' can be the same or different. For example, columns whose temperature detection signals do not exceed the preset temperature threshold but are closer to it are applied with a reduced voltage or current amplitude, while columns whose temperature detection signals do not exceed the preset temperature threshold but are farther from it are applied with a increased voltage or current amplitude. This achieves a tumor electric field therapy system 100' based on an alternating electrical signal application control method using temperature detection signals.

[0326] It should be noted that the alternating electrical signal application method, electrode temperature detection method, electrode temperature anomaly detection method, control method, and electrode type identification method of the tumor electric field therapy system 100' in this embodiment are similar to the control method of the aforementioned tumor electric field therapy system 100. The difference is that the tumor electric field therapy system 100' in this embodiment can also apply different alternating electrical signals, such as different voltages or currents, to the electrode units 33' in each region (i.e., each column group) according to the temperature of the electrode units 33' in each region, to prevent the electrode units 33' in the corresponding region from exceeding the preset temperature threshold, so as to apply the electric field continuously for a long time and improve the treatment effect.

[0327] Specifically, the tumor electric field therapy system 100' in this embodiment can use the electrode temperature detection method shown in FIG8 to determine the temperature of each electrode unit 33' in the electrode sheet 13'. Please refer to FIG8 for details, which will not be repeated here.

[0328] The tumor electric field therapy system 100' of this embodiment can use the electrode temperature anomaly detection method shown in Figure 9 to determine whether the electrode 13' is abnormal. See Figure 9 for details; further explanation is omitted here.

[0329] The tumor electric field therapy system 100' of this embodiment can use the control method of the tumor electric field therapy system shown in FIG21 to control the intensity of the alternating electrical signal applied to the electrode unit 33', specifically including the following steps:

[0330] Step 210': Control the switching unit so that at least one column group of the corresponding electrode sheet 13' is connected to the corresponding temperature sampling point.

[0331] Step 220': Control the control switch 54' corresponding to each row group so as to sample the analog temperature signal of the corresponding electrode unit 33' based on the corresponding temperature sampling point, so as to determine the temperature detection signal of each electrode unit 33' in each electrode sheet 13'. Specification 41 / 46 pages 45 CN 121371480 A

[0332] Step 240': Control the intensity of the alternating electrical signal applied to the electrode unit 33' according to the temperature detection signal.

[0333] Specifically, when it is determined that the electrode sheet 13' does not need to be replaced, the alternating electrical signal applied to each electrode unit 33' in the electrode sheet 13' is controlled or adjusted according to the temperature detection signal detected by the temperature detection unit 35' corresponding to each electrode unit 33' in the electrode sheet 13'.

[0334] In some embodiments, controlling the intensity of the alternating electrical signal applied to the electrode unit 33' according to the temperature detection signal in step 240' specifically includes the following steps:

[0335] Step 241': Compare the temperature at each electrode unit 33' in the electrode sheet 13' with a preset temperature threshold according to the temperature detection signal.

[0336] Step 242': Control the intensity of the alternating electrical signal according to the comparison result.

[0337] In some embodiments, controlling the intensity of the alternating electrical signal according to the comparison result in step 242' specifically includes:

[0338] Step 2421': When the temperature at at least one electrode unit 33' exceeds the preset temperature threshold, stop applying the alternating electrical signal to the electrode unit 33' of the electrode sheet 13'. Specifically, when any temperature detection signal in all electrode units 33' of the acquired electrode sheet 13' exceeds a preset temperature threshold, the application of alternating electrical signals to the electrode units 33' of the electrode sheet 13' is stopped. When none of the acquired temperature detection signals of any electrode unit 33' in the electrode sheet 13' exceed the preset temperature threshold, the application of alternating electrical signals to each electrode unit 33' of the electrode sheet 13' continues.

[0339] In some embodiments, stopping the application of alternating electrical signals to the electrode units 33' of the electrode sheet 13' in step 2421' specifically includes: stopping the application of alternating electrical signals to all electrode units 33' of the electrode sheet 13'; or stopping the application of alternating electrical signals to all electrode units 33' in the column group containing the electrode unit 33' that exceeds the preset temperature threshold.

[0340] Furthermore, while ceasing the application of alternating electrical signals to all electrode units 33' in the column group containing electrode units 33' that exceed the preset temperature threshold, alternating electrical signals continue to be applied to electrode units 33' in other columns of the electrode sheet 13'. The intensity of the alternating electrical signals applied to the electrode units 33' in other columns of the electrode sheet 13' is adjustable. For example, all electrode units 33' in the electrode sheet 13' whose temperature detection signal does not exceed the preset temperature threshold and are in a different column from the electrode units 33' whose temperature detection signal exceeds the preset temperature threshold are still subject to alternating electrical signals. The alternating electrical signals applied to different columns can be the same or different; for example, the voltage or current amplitude of the alternating electrical signal applied to columns closer to but not exceeding the preset temperature threshold is smaller, and vice versa.

[0341] In some other embodiments, controlling the alternating electrical signal intensity based on the comparison result in step 242' specifically includes:

[0342] Step 2422': If the temperature at all electrode units 33' in the electrode sheet 13' does not exceed a preset temperature threshold, and if the temperature at all electrode units 33' in the electrode sheet 13' does not exceed a first preset temperature, then the alternating electrical signal intensity applied to the electrode units 33' of the electrode sheet 13' is increased, wherein the first preset temperature is less than the preset temperature threshold.

[0343] In step 2422', the increase in electric field intensity corresponding to each column group whose alternating electrical signal intensity is increased can be the same or different, that is, they can be adjusted separately. For example, the voltage or current amplitude of the alternating electrical signal applied to the column group with the lower highest temperature is larger, and vice versa.

[0344] Step 2423': If the temperature at all electrode units 33' in the electrode sheet 13' does not exceed the preset temperature threshold, and if the temperature at at least one electrode unit 33' in the electrode sheet 13' exceeds the first preset temperature but is less than the second preset temperature, then the alternating electrical signal strength currently applied to the electrode unit 33' of the electrode sheet 13' remains unchanged.

[0345] In step 2423', keeping the alternating electrical signal strength currently applied to the electrode unit 33' unchanged specifically includes: keeping the alternating electrical signal strength currently applied to the first target column group unchanged, wherein the first target column group is the column group where the temperature at electrode unit 33' exceeds the first preset temperature but is less than the second preset temperature. That is, only the voltage or current amplitude of the alternating electrical signal corresponding to the column group whose temperature exceeds the first preset temperature but is less than the second preset temperature can be kept unchanged, while the voltage or current amplitude of the alternating electrical signal corresponding to the other column groups can still be adjusted according to the temperature of the corresponding column group.

[0346] Step 2424': The temperature at all electrode units 33' in electrode sheet 13' does not exceed the preset temperature threshold.In the case where the temperature at at least one electrode unit 33' in the electrode sheet 13' exceeds the second preset temperature but is less than the preset temperature threshold, the intensity of the alternating electrical signal applied to the electrode unit 33' of the electrode sheet 13' is reduced.

[0347] In step 2424', reducing the intensity of the alternating electrical signal applied to the electrode unit 33' specifically includes: reducing the intensity of the alternating electrical signal applied to the electrode units 33' of the second target column group, wherein the second target column group is the column group where the temperature at the electrode unit 33' exceeds the second preset temperature but is less than the preset temperature threshold. That is, only the voltage or current amplitude of the alternating electrical signal corresponding to the column group whose temperature exceeds the second preset temperature but is less than the preset temperature threshold can be reduced, and the reduced amplitude can be the same or different, while the voltage or current amplitude of the alternating electrical signal corresponding to the other column groups can still be adjusted according to the temperature of the corresponding column group, for example, maintained or increased.

[0348] For example, when the temperature detection signal is much lower than the preset temperature threshold, the alternating electrical signal is continued to be applied to each electrode unit 33' of the electrode sheet 13' by increasing the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33' of the electrode sheet 13', wherein the voltage or current amplitude of the alternating electrical signal applied to different columns may be the same or different, or the alternating electrical signal is continued to be applied to each electrode unit 33' of the electrode sheet 13' by keeping the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33' of the electrode sheet 13' unchanged, wherein the voltage or current amplitude of the alternating electrical signal applied to only some columns may remain unchanged. When the temperature detection signal approaches the preset temperature threshold, the alternating electrical signal continues to be applied to each electrode unit 33' of the electrode plate 13' in a manner that keeps the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33' of the electrode plate 13' constant. This can be achieved by keeping the voltage or current amplitude of the alternating electrical signal applied to only a portion of the column groups constant, or by reducing the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33' of the electrode plate 13'. The voltage or current amplitudes of the alternating electrical signals applied to different column groups can be the same or different.

[0349] In some other embodiments, step 242', controlling the alternating electrical signal intensity based on the comparison result, specifically includes:

[0350] Step 2425': If the temperature at at least one electrode unit 33' exceeds the preset temperature threshold, determine the number of overheated column groups.

[0351] Step 2426': If the number of overheated groups exceeds a preset threshold, stop applying alternating electrical signals to all electrode units 33' of electrode plate 13'.

[0352] Step 2427': If the number of overheated groups does not exceed a preset threshold, stop applying alternating electrical signals to electrode plate 13'.Alternating current signals are applied to all electrode units 33' in the column group where the electrode unit 33' that exceeds the preset temperature threshold is located.

[0353] Further, when the application of alternating current signals to all electrode units 33' in the column group where the electrode unit 33' that exceeds the preset temperature threshold is located is stopped, alternating current signals are continued to be applied to electrode units 33' in other columns of the electrode sheet 13'. The intensity of the alternating current signals applied to the electrode units 33' in other columns of the electrode sheet 13' is adjustable. For example, all electrode units 33' in the electrode sheet 13' whose temperature detection signal does not exceed the preset temperature threshold and are in a different column from the electrode unit 33' whose temperature detection signal exceeds the preset temperature threshold are continued to be applied with alternating current signals, and the alternating current signals applied to different columns can be the same or different. For example, the voltage or current amplitude of the alternating current signal applied to the column group that is closer to the preset temperature threshold but does not exceed the preset temperature threshold is smaller, and vice versa.

[0354] Step 2428': If the number of overheated columns does not exceed a preset threshold, and if the temperature at each electrode unit 33' in the non-overheated columns does not exceed a first preset temperature, then the intensity of the alternating electrical signal applied to the electrode unit 33' of the non-overheated columns is increased, wherein the first preset temperature is less than a preset temperature threshold.

[0355] In step 2428', the increase in electric field intensity corresponding to each column whose alternating electrical signal intensity is increased can be the same or different, that is, they can be adjusted separately. For example, the voltage or current amplitude of the alternating electrical signal applied to the column with the lower highest temperature is larger, and vice versa.

[0356] Step 2429': If the number of overheated columns does not exceed a preset threshold, and if at least one electrode unit 33' in the non-overheated columns has a temperature exceeding a first preset temperature but less than a preset temperature threshold, then the alternating electrical signal strength currently applied to the electrode unit 33' in the non-overheated columns remains unchanged.

[0357] In step 2429', maintaining the alternating electrical signal strength currently applied to the electrode unit 33' specifically includes: maintaining the alternating electrical signal strength currently applied to the first target column group, wherein the first target column group is the column group where the temperature at the electrode unit 33' exceeds the first preset temperature but is less than a preset temperature threshold. That is, only the voltage or current amplitude of the alternating electrical signal corresponding to the column group whose temperature exceeds the first preset temperature but is less than the preset temperature threshold can be maintained, while the voltage or current amplitude of the alternating electrical signal corresponding to the other column groups can still be adjusted according to the temperature of the corresponding column group.

[0358] Step 2430': If the number of overheated groups does not exceed a preset threshold, and if at least one electrode unit 33' in the non-overheated groups has a temperature exceeding a second preset temperature but less than a preset temperature threshold, then reduce the flow of electricity to the non-overheated groups.The alternating electrical signal intensity applied to the electrode unit 33' of the over-temperature column group, wherein the second preset temperature is greater than the first preset temperature and less than the preset temperature threshold.

[0359] In step 2430', reducing the alternating electrical signal intensity applied to the electrode unit 33' specifically includes: reducing the alternating electrical signal intensity applied to the electrode unit 33' of the second target column group, wherein the second target column group is a column group where the temperature at the electrode unit 33' exceeds the second preset temperature and is less than the preset temperature threshold. That is, only the voltage or current amplitude of the alternating electrical signal corresponding to the column group whose temperature exceeds the second preset temperature and is less than the preset temperature threshold can be reduced, and the reduced amplitude can be the same or different, while the voltage or current amplitude of the alternating electrical signal corresponding to the other column groups can still be adjusted according to the temperature of the corresponding column group, for example, maintained or increased.

[0360] For example, when the temperature detection signal is much lower than the preset temperature threshold, the alternating electrical signal is continued to be applied to each electrode unit 33' of the electrode sheet 13' by increasing the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33' of the electrode sheet 13', wherein the voltage or current amplitude of the alternating electrical signal applied to different columns may be the same or different, or the alternating electrical signal is continued to be applied to each electrode unit 33' of the electrode sheet 13' by keeping the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33' of the electrode sheet 13' unchanged, wherein the voltage or current amplitude of the alternating electrical signal applied to only some columns may remain unchanged. When the temperature detection signal approaches the preset temperature threshold, the alternating electrical signal continues to be applied to each electrode unit 33' of the electrode plate 13' in a manner that the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33' of the electrode plate 13' remains unchanged. This can be achieved by keeping the voltage or current amplitude of the alternating electrical signal applied to only a portion of the columns constant, or by reducing the voltage or current amplitude of the alternating electrical signal applied to each electrode unit 33' of the electrode plate 13'. The voltage or current amplitudes of the alternating electrical signals applied to different columns can be the same or different.

[0361] The tumor electric field therapy system 100' of this embodiment can use the electrode plate type identification method shown in FIG11 to identify the type of the electrode plate 13'. See FIG11 for details, which will not be elaborated here.

[0362] The tumor electric field therapy system 100' of this embodiment can use the signal control method for tumor electric field therapy shown in FIG22 to combine and control the control switch 54' and the bidirectional switching switch 55' electrically connected to the electrode sheet 13' so that each electrode unit 33' of the electrode sheet 13' switches between applying an alternating electrical signal and collecting a temperature detection signal. Specification 44 / 46 pages 48 CN 121371480 A

[0363] Referring to FIG22, the method includes:

[0364] Step 310': Combine the control switch 54' and the bidirectional switching switch 55' that are electrically connected to the corresponding electrode sheet 13' to apply alternating electrical signals to each electrode unit 33' of the electrode sheet 13' and execute step 320';

[0365] Applying alternating electrical signals to each electrode unit 33' of the electrode sheet 13' in step 310' specifically includes: simultaneously applying the same or different alternating electrical signals to the electrode units 33' of some or all of the column groups in all column groups.

[0366] Step 320': Combine the control switch 54' and the bidirectional switching switch 55' electrically connected to the electrode sheet 13' to collect the temperature detection signals of each electrode unit 33' of the electrode sheet 13' in rows and execute step 330';

[0367] The collection of the temperature detection signals of each electrode unit 33' of the electrode sheet 13' in rows in step 320' specifically includes: sampling the temperature detection signals of all electrode units 33' of some or all row groups in all row groups in the same sampling time period; or sampling the temperature detection signals of some electrode units 33' of some or all row groups in all row groups in the same sampling time period.

[0368] Step 330': Determine the combined control mode of the control switch 54' and the bidirectional switching switch 55' electrically connected to the electrode plate 13' based on the collected temperature detection signal and execute step 340';

[0369] Step 340': Control the working state of each electrode unit 33' of the electrode plate 13' according to the determined combined control mode of the control switch 54' and the bidirectional switching switch 55'.

[0370] The working state of each electrode unit 33' of the electrode plate 13' in step 340' includes at least one of: stopping the application of alternating current signal and continuing to collect temperature detection signal, and stopping the collection of temperature detection signal and continuing to apply alternating current signal. Continuing to apply alternating current signal includes: continuing to apply alternating current signal by increasing the voltage or current amplitude of the currently applied alternating current signal, or continuing to apply alternating current signal by keeping the voltage or current amplitude of the currently applied alternating current signal unchanged, or continuing to apply alternating current signal by decreasing the voltage or current amplitude of the currently applied alternating current signal. The alternating current signals corresponding to different columns can be applied in the same or different ways.

[0371] The working state of each electrode unit 33' of the electrode sheet 13' is determined by the temperature detection signal it collects. Each electrode unit 33' of the electrode sheet 13' is divided into different regions. By controlling the combination of the control switch 54' and the bidirectional switching switch 55', each electrode unit 33' in each region can be cyclically switched between applying an alternating current signal and collecting a temperature detection signal. When applying an alternating current signal, different regions can be the same or different.

[0372] The tumor electric field therapy system 100' of this embodiment can use the electrode sheet temperature detection method shown in FIG13 to apply the alternating current signal.The temperature of electrode 13' is detected, as shown in Figure 13, and will not be described in detail here.

[0373] The tumor electric field therapy system 100' of this embodiment can apply an alternating electric signal to electrode 13' using the alternating electric signal application method for tumor electric field therapy shown in Figures 14-16. The difference is that when applying the alternating electric signal, the alternating electric signals applied to different columns can be the same or different, and will not be described in detail here.

[0374] This application also provides a tumor electric field therapy system 100 or 100', comprising: at least one pair of the aforementioned electrode pads 13 or 13'; an electric field generator 30 or 30', the electric field generator 30 or 30' being used to generate alternating power and transmit the alternating power to each electrode pad 13 or 13' via an alternating power line 57 or 57'; and a control unit (such as a first controller 51 or 51' or a second controller 37 or 37', etc.), the control unit being used to configure at least one of the switching state of a control switch 54 or 54' and the switching state of a switching unit (unlabeled), so as to sample the analog temperature signal detected by the corresponding temperature detection unit 35 or 35' in each row group based on the corresponding temperature sampling point (unlabeled), or to control the electrode units 33 or 33' of at least one column group to be applied an alternating electrical signal based on the alternating power line 57 or 57'.

[0375] This application also provides a tumor treatment device (not shown), including: the aforementioned tumor electric field therapy system 100 or 100'. Specification 45 / 46 pages 49 CN 121371480 A

[0376] This application also provides a computer-readable storage medium storing a computer program thereon, which, when executed by a processor, implements the aforementioned electrode temperature detection method; or the aforementioned electrode abnormality detection method; or the aforementioned control method for the tumor electric field therapy system; or the aforementioned electrode type identification method.

[0377] This application also provides a tumor electric field therapy adapter 20 or 20', including a first memory (not shown) and a first controller 51 or 51', the first memory (not shown) storing a computer program, which, when executed by the first controller 51 or 51', implements the aforementioned electrode temperature detection method; or the aforementioned electrode abnormality detection method; or the aforementioned control method for the tumor electric field therapy system; or the aforementioned electrode type identification method.

[0378] This application also provides an electric field generator 30 or 30' for tumor electric field therapy, including a second memory (not shown) and a second controller 37 or 37'. The second memory (not shown) stores a computer program, which, when executed by the second controller 37 or 37', implements the aforementioned electrode temperature detection method; or the aforementioned electrode abnormality detection method; or the aforementioned control method for a tumor electric field therapy system; or the aforementioned electrode type identification method.

[0379] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and not to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. These modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this application, and they should all be covered within the scope of the claims and specification of this application. In particular, as long as there is no structural conflict, the various technical features mentioned in the embodiments can be combined in any way. This application is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims. Instruction manual page 46 / 46, 50 CN 121371480 A, Figure 1; Instruction manual figure 1 / 16, 51 CN 121371480 A, Figure 2; Instruction manual figure 2 / 16, 52 CN 121371480 A, Figure 3; Instruction manual figure 3 / 16, 53 CN 121371480 A, Figure 4; Instruction manual figure 4 / 16, 54 CN 121371480 A, Figure 5; Instruction manual figure 5 / 16, 55 CN 121371480 A, Figure 6; Instruction manual figure 6 / 16, 56 CN 121371480 A, Figure 7; Instruction manual figure 7 / 16, 57 CN 121371480 A, Figure 9; Figure 10; Figure 11; Instruction manual figure 8 / 16, 58 CN 121371480 A, Figure 12; Figure 13; Figure 14; Instruction manual figure 9 / 16, 59 CN 121371480 A Figure 15 Appendix to the Specification, Page 10 / 16, 60 CN 121371480 A Figure 16 Appendix to the Specification, Page 11 / 16, 61 CN 121371480 A Figure 17 Appendix to the Specification, Page 12 / 16, 62 CN 121371480 A Figure 18 Appendix to the Specification, Page 13 / 16, 63 CN 121371480 A Figure 19 Appendix to the Specification, Page 14 / 16, 64 CN 121371480 A Figure 20 Figure 21 Appendix to the Specification, Page 15 / 16, 65 CN 121371480 A Figure 22 Appendix to the Specification, Page 16 / 16, 66 CN 121371480 A Abstract The present invention provides a tumorelectric field therapy system comprising a transducer array and a controller. The transducer array comprises a plurality of electrode units and a plurality of temperature detection units. The plurality of temperature detection units are divided into a plurality of row groups and a plurality of column groups. The grounding terminals of the respective temperature detection units in each row group are commonly connected to a same grounding line, and the signal terminals of the respective temperature detection units in each column group are respectively short-circuited to the corresponding electrode units and then connected to a same dual- purpose signal line. The dual-purpose signal line can be selectively connected to a direct current signal or an alternating current signal. When the dual-purpose signal lines are connected to the direct current signal, the grounding lines are sequentially conducted, so that the temperature detection signals detected by the respective temperaturedetection units are collected row by row. When the dual-purpose signal lines are connected to the alternating current signal, an alternating current signal is transmitted to the respective electrode units. In this manner, temperature detection and zonal control of the transducer array can be achieved by using fewer conductive traces.

Claims

1. A tumor electric field therapy system, characterized in that, include: An electrode sheet includes multiple electrode units and multiple temperature detection units. Each electrode unit can be subjected to an alternating electrical signal. Each temperature detection unit is configured to detect the temperature at each electrode unit. The signal terminals of each temperature detection unit are short-circuited to the corresponding electrode unit. The multiple temperature detection units are configured in the circuit as multiple row groups and multiple column groups. The ground terminals of the temperature detection units in the same row group are short-circuited to the same grounding line. The ground terminals of the temperature detection units in different row groups are connected in parallel through different grounding lines. The signal terminals of the temperature detection units in the same column group are short-circuited to the same dual-purpose signal line. The signal terminals of the temperature detection units in different column groups are connected in parallel through different dual-purpose signal lines. The grounding line is configured to ground the ground terminals of the temperature detection units in the corresponding row group. The dual-purpose signal line is configured to receive an AC signal to transmit an AC signal to the electrode units in the corresponding column group or to receive a DC signal to transmit a DC signal to the signal terminals of the temperature detection units in the corresponding column group. as well as The controller is configured to combine control of each of the grounding wires and each of the dual-purpose signal lines so that (1) when a DC signal is connected to the dual-purpose signal line, each of the grounding wires is sequentially turned on so that the temperature detection signals detected by each of the temperature detection units are collected row by row; (2) when an AC signal is connected to the dual-purpose signal line, the alternating signal is transmitted to each of the electrode units in the corresponding column group through the dual-purpose signal line.

2. The tumor electric field therapy system according to claim 1, characterized in that, The controller is also configured to: The operating state of each electrode unit is determined based on the temperature detection signals; or The strength of the transmitted alternating electrical signal is controlled or adjusted according to the temperature detection signals described above; or The electrode sheet is judged to be qualified based on the temperature detection signals; or Based on the temperature detection signals, determine whether the temperature detection unit is abnormal or faulty; or The electrode type is identified based on the acquired temperature detection signals; or The electrode unit is over-temperature determined based on the temperature detection signals; or The electrode replacement is determined based on the temperature detection signals.

3. The tumor electric field therapy system according to claim 1, characterized in that, The controller is configured to have a preset temperature threshold and is set to: Compare each of the temperature detection signals with the preset temperature threshold; and The operating state of each electrode unit is determined based on the comparison results, or the strength of the alternating electrical signal transmitted to each electrode unit is controlled.

4. The tumor electric field therapy system according to claim 3, characterized in that, The comparison result is either exceeding a preset temperature threshold or not exceeding a preset temperature threshold. The electrode unit corresponding to the temperature detection signal exceeding the preset temperature threshold is an over-temperature electrode unit, and the electrode unit corresponding to the temperature detection signal not exceeding the preset temperature threshold is a non-over-temperature electrode unit.

5. The tumor electric field therapy system according to claim 4, characterized in that, The controller is also configured to: When at least one of the aforementioned overheating electrode units exists, control each of the dual-purpose signal lines to stop transmitting AC signals to each of the electrode units; or When at least one of the overheating electrode units exists, the dual-purpose signal line electrically connected to the overheating electrode unit is controlled to stop transmitting AC signals to each of the electrode units in the corresponding column group, and at the same time, the dual-purpose signal line corresponding to the column group consisting entirely of non-overheating electrode units is controlled to continue transmitting AC signals to each of the electrode units in the corresponding column group.

6. The tumor electric field therapy system according to claim 4, characterized in that, The controller is further configured to have a preset quantity threshold and to: When at least one of the aforementioned overheat electrode units exists, the number of overheat arrays is determined; and When the number of the overheated arrays exceeds a preset threshold, control each of the dual-purpose signal lines to stop transmitting AC signals to all electrode units of the electrode sheet; or When the number of the overheated arrays does not exceed a preset threshold, the dual-purpose signal line electrically connected to the overheated electrode unit is controlled to stop transmitting AC signals to each electrode unit in the overheated array, and the dual-purpose signal line corresponding to the non-overheated array is controlled to transmit AC signals to each electrode unit in the remaining arrays of the electrode sheet.

7. The tumor electric field therapy system according to claim 6, characterized in that, The intensity of the AC signal transmitted to each of the electrode units in the remaining columns of the electrode sheet is adjustable.

8. The tumor electric field therapy system according to claim 6, characterized in that, The intensity of the AC signal transmitted to each of the electrode units in the remaining columns of the electrode sheet is adjustable.

9. The tumor electric field therapy system according to claim 4, characterized in that, The controller is configured to have a first preset temperature that is less than the preset temperature threshold, wherein the temperature is: Compare each of the temperature detection signals with the first preset temperature; and When all the temperature detection signals are lower than the first preset temperature, control each of the dual-purpose signal lines to transmit an AC signal with increased voltage or current amplitude to each of the electrode units; or When all the temperature detection signals are less than the preset temperature threshold and at least one of the temperature detection signals exceeds the first preset temperature of the electrode unit, the alternating electrical signal with a constant voltage or current amplitude is transmitted from each of the dual-purpose signal lines to each of the electrode units; or When at least one of the aforementioned over-temperature electrode units is present, the dual-purpose signal line is controlled to stop transmitting the AC signal to the electrode unit.

10. The tumor electric field therapy system according to claim 9, characterized in that, Stopping the transmission of AC signals to the electrode units includes: stopping the transmission of AC signals to all the electrode units; or stopping the transmission of AC signals to each of the electrode units in the same column as the overheating electrode unit, while continuing to transmit AC signals to each of the electrode units in the remaining columns.

11. The tumor electric field therapy system according to claim 4, characterized in that, The controller has a first preset temperature and a second preset temperature, wherein the first preset temperature is less than the second preset temperature and the second preset temperature is less than a preset temperature threshold. When none of the temperature detection signals exceed the preset threshold, the controller is further configured to: Compare each of the temperature detection signals with the first preset temperature; When none of the temperature detection signals exceed the first preset temperature, control each dual-purpose signal line to transmit an AC signal with increased voltage or current amplitude to each electrode unit; When at least one of the temperature detection signals exceeds the first preset temperature, the temperature detection signal exceeding the first preset temperature is compared with the second preset temperature; When none of the temperature detection signals exceed the second preset temperature, control each of the dual-purpose signal lines to transmit an AC signal with a constant voltage or current amplitude to each of the electrode units; When at least one of the temperature detection signals exceeds the second preset temperature, the alternating electrical signal with reduced voltage or current amplitude is transmitted from each of the dual-purpose signal lines to each of the electrode units.

12. The tumor electric field therapy system according to claim 4, characterized in that, The controller is configured to: When the temperature detection signals are all much lower than the preset temperature threshold, the dual-purpose signal line is controlled to transmit an alternating electrical signal with an increased or unchanged voltage or current amplitude to the electrode unit. When the temperature detection signal approaches the preset temperature threshold, the dual-purpose signal line is controlled to transmit an alternating electrical signal with a constant or reduced voltage or current amplitude to the electrode unit.

13. The tumor electric field therapy system according to claim 1, characterized in that, The controller is configured to: Determine the regions where each of the electrode units requires the application of an AC signal; and The control system transmits AC signals to each of the electrode units that require AC signals, using the dual-purpose signal line corresponding to the area it is located.

14. The tumor electric field therapy system according to any one of claims 1-13, characterized in that, Each column of electrode units is connected to the same alternating power supply line via a corresponding dual-purpose signal line.

15. The tumor electric field therapy system according to any one of claims 1-13, characterized in that, The electrode units of each column are connected to different alternating power supply lines via corresponding dual-purpose signal lines.

16. The tumor electric field therapy system according to any one of claims 1-13, characterized in that, It also includes an AC signal generator electrically connected to the controller, the controller being configured to control the intensity of the AC signal generated by the AC signal based on each of the temperature detection signals.

17. The tumor electric field therapy system according to claim 16, characterized in that, The controller includes a power supply switch electrically connected to the AC signal generator, and controls the closing and opening of the power supply switch.

18. The tumor electric field therapy system according to claim 17, characterized in that, The power supply switch is one; or the power supply switch is multiple and its number is equal to the number of the column groups.

19. The tumor electric field therapy system according to claim 16, characterized in that, It includes multiple control switches and multiple bidirectional switching switches. Each grounding wire is grounded through a control switch connected in series with it, and each dual-purpose signal line is connected to a DC signal or an AC signal through a bidirectional switching switch connected in series with it.

20. The tumor electric field therapy system according to claim 16, characterized in that, The controller is configured to: When the dual-purpose signal line is connected to an AC signal, all of the aforementioned grounding lines are disconnected; or When a DC signal is connected to the dual-purpose signal line, the grounding lines are controlled to be turned on sequentially in a time-sharing manner.

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