Pyridazine compounds, their preparation, and their therapeutic uses

Abstract

The present invention relates to a compound of formula (I) wherein n is 1 or 2, R1 is halogen, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkoxy, ethynyl, propargyl, or (C3-C6)cycloalkyl, or two R1 form a cyclopentane ring fused to the phenol; R2 and R3 represent H, cyano, ethynyl, propargyl, (C1-C4)alkyl, hydroxy(C1-C4)alkyl or a halo(C1-C4)alkyl, or R2 and R3 form together with the atoms connecting them a (C5- C6)carbocyclic ring fused to the pyridazine ring; R4 and R5 form together with N to which they are attached an optionally substituted 3-7 membered monocyclic heterocycloalkyl ring, 8-11 membered bicyclic heterocycloalkyl ring or 7-12 membered bicyclic heterocyclic spiro ring. The present invention also relates to a medicament and a pharmaceutical composition comprising said compound of formula (I), as well as their therapeutic uses, in particular as inhibitor of NOD-like receptor protein 3 inflammasome for treating for example Parkinson's disease or frontotemporal Dementia.

Description

Abstract This invention relates to a compound of formula (I), wherein n is 1 or 2, R1 is a halogen, (C1-C4) alkyl, halo(C1-C4) alkyl, (C1-C4) alkoxy, halo(C1-C4) alkoxy, ethynyl, propargyl, or (C3-C6) cycloalkyl, or two R1s form a cyclopentane ring fused to phenol; R2 and R3 represent H, cyano, ethynyl, propargyl, (C1-C4) alkyl, hydroxy(C1-C4) alkyl, or halo(C1-C4) alkyl, or R2 and R3 together with the atoms attached to them form a (C5-C6) carbon ring fused to a pyridazine ring; R4 and R5 together with the N to which they are attached form an optionally substituted 3-7 membered monocyclic heterocyclic alkyl ring, 8-11 The invention relates to a 7-12 membered bicyclic heterocyclic alkyl ring or a 7-12 membered bicyclic heterocyclic spirocyclic ring. The invention also relates to pharmaceutical agents and pharmaceutical compositions comprising compounds of formula (I), and their therapeutic uses, particularly as inhibitors of the NOD-like receptor protein 3 inflammasome for the treatment of, for example, Parkinson's disease or frontotemporal dementia.

Claims

CLAIMS 1. A compound of formula (I) or a pharmaceutically acceptable salt thereof R2 R3wherein n is 1 or 2; R1 represent independently of each other a halogen atom, a (C1-C4)alkyl group, a halo(C1-C4)alkyl group, a (C1-C4)alkoxy group, a halo(C1-C4)alkoxy group, a group of formulaR6in which R6 is a hydrogen atom or a methyl group and the symbolrepresents the attachment site between the carbon atom and the phenyl ring, or a (C3-C6)cycloalkyl group; or two R1 which are on adjacent carbon atoms form together with the atoms connecting them a cyclopentane ring which is fused to the phenol group; R2 and R3 represent independently of each other a hydrogen atom, a cyano group, a (C1-C4)alkyl group, a hydroxy(C1-C4)alkyl group, a halo(C1-C4)alkyl group, or a group of formulaR6in which R6 is a hydrogen atom ora methyl group and the symbol represents the attachment site between the carbon atom and the pyridazine ring; or R2 and R3 which are on adjacent carbon atoms form together with the atoms connecting them a (C5-C6)carbocyclic ring which is fused to the pyridazine ring; R4 and R5 form together with the nitrogen atom to which they are attached: - a 3 to 7 membered monocyclic heterocycloalkyl ring comprising one nitrogen atom and optionally one additional heteroatom selected from a nitrogen atom, an oxygen atom and a sulfur atom and comprising 2 to 6 carbon atoms,- a 8 to 11 membered bicyclic heterocycloalkyl ring comprising one nitrogen atom and optionally one to three additional heteroatoms independently selected from a nitrogen atom, an oxygen atom and a sulfur atom and comprising 4 to 10 carbon atoms, or - a 7 to 12 membered bicyclic heterocyclic spiro ring comprising one nitrogen atom and optionally one to three additional heteroatoms selected from a nitrogen atom, an oxygen atom and a sulfur atom and comprising 3 to 11 carbon atoms, said monocyclic heterocycloalkyl ring, bicyclic heterocycloalkyl ring and bicyclic heterocyclic spiro ring being unsubstituted or substituted by one to two substituents independently selected from a (C1-C4)alkyl- group, a NH2group, a mono(C1-C4)alkylamino- group, a di(C1-C4)alkylamino- group, a NH2-(C1- C4)alkyl- group, a mono(C1-C4)alkylamino-(C1-C4)alkyl- group, a di(C1- C4)alkylamino-(C1-C4)alkyl- group, NH2-(C3-C6)cycloalkyl- group, a OH-(C3- C6)cycloalkyl- group, a mono(C1-C4)alkylamino-(C3-C6)cycloalkyl- group, a di(C1-C4)alkylamino-(C3-C6)cycloalkyl- group, a (C2-C5)acylamino-(C1- C4)alkyl- group, a (C2-C5)acylamino- group, a (C2-C5)acyl group, a hydroxy- (C1-C4)alkyl- group, a SH-(C1-C4)alkyl- group, a CN-(C1-C4)alkyl- group, a (C1- C4)alkoxy-(C1-C4)alkyl- group, a hydroxyl group, an oxo group, a (C3- C6)cycloalkyl group, a halogen atom, a halo(C1-C4)alkyl- group, a cyano group, a NH2-C(=O)- group, a mono(C1-C4)alkylamino-C(=O)- group, a di(C1- C4)alkylamino-C(=O)- group, a NH2-C(=O)-(C1-C4)alkyl- group, a mono(C1- C4)alkylamino-C(=O)-(C1-C4)alkyl- group, a di(C1-C4)alkylamino-C(=O)-(C1- C4)alkyl- group or a -CO2H group.

2. A compound of formula (I) or a pharmaceutically acceptable salt thereof according to claim 1, wherein n is 1.

3. A compound of formula (I) or a pharmaceutically acceptable salt thereof according to claim 1, wherein n is 2.

4. A compound of formula (I) or a pharmaceutically acceptable salt thereof according to any one of claims 1 to 3, wherein R1 represent independently ofeach other a halogen atom, a (C1-C4)alkyl group, a (C1-C4)alkoxy group, a halo(C1-C4)alkoxy group, a (C3-C6)cycloalkyl group, a group of formula R6 in which R6 is a hydrogen atom or a methyl group and the symbol the attachment site between the carbon atom and the phenylring, or a halo(C1-C4)alkyl group, in particular R1 represent independently of each other a fluorine atom, a chlorine atom, a methyl group, an ethyl group, an isopropyl group, a methoxy group, a trifluoromethoxy group, a cyclopropyl group, a -CHF2 group, an ethynyl group or a trifluoromethyl group, or two R1 which are on adjacent carbon atoms form together with the atoms connecting them a cyclopentane ring which is fused to the phenol group, in particular these two R1 represent a group of formularepresents the attachment site between the carbon atom of the phenol ring and the carbon atom of the pyridazine ring.

5. A compound of formula (I) or a pharmaceutically acceptable salt thereof according any one of claims 1 to 4, wherein - when n is 1, R1 is in ortho, meta or para position on the phenyl with respect to pyridazine ring, or - when n is 2, the two R1 are in ortho and in para position on the phenyl with respect to pyridazine ring, or - when n is 2, the two R1 are in ortho and in meta position on the phenyl with respect to pyridazine ring.

6. A compound of formula (I) or a pharmaceutically acceptable salt thereof according any one of claims 1 to 5, whereinR2 and R3 represent independently of each other a hydrogen atom, a cyano group, a halo(C1-C4)alkyl group, a hydroxy(C1-C4)alkyl group, or a (C1-C4)alkyl group; in particular R2 and R3 represent independently of each other a hydrogen atom, a cyano group, a -CHF2group, a trifluoromethyl group, a -CH2OH group, a methyl group, an ethyl group or an isopropyl group.

7. A compound of formula (I) or a pharmaceutically acceptable salt thereof according any one of claims 1 to 5, wherein R2 and R3 which are on adjacent carbon atoms form together with the atoms connecting them a (C5-C6)carbocyclic ring which is fused to the pyridazine ring, in particular R2 and R3 which are on adjacent carbon atoms form together with the atoms connecting them a cyclopentyl ring which is fused to the pyridazine ring.

8. A compound of formula (I) or a pharmaceutically acceptable salt thereof according any one of claims 1 to 6, wherein R4 and R5 form together with the nitrogen atom to which they are attached: - a 4 to 7 membered monocyclic heterocycloalkyl ring comprising one nitrogen atom and optionally one additional heteroatom selected from a nitrogen atom, an oxygen atom and a sulfur atom and comprising 3 to 6 carbon atoms, - a 8 to 10 membered bicyclic heterocycloalkyl ring comprising one nitrogen atom and optionally one or two additional heteroatoms independently selected from a nitrogen atom, an oxygen atom and a sulfur atom and comprising 6, 7, 8 or 9 carbon atoms, or - a 7 to 10 or 12 membered bicyclic heterocyclic spiro ring comprising one nitrogen atom and optionally one to three additional heteroatoms selected from a nitrogen atom, an oxygen atom and a sulfur atom and comprising 5 to 8 carbon atoms, said monocyclic heterocycloalkyl ring, bicyclic heterocycloalkyl ring and bicyclic heterocyclic spiro ring being unsubstituted or substituted by one to two substituents independently selected from a (C1-C4)alkyl- group, a NH2group, a mono(C1-C4)alkylamino- group, a di(C1-C4)alkylamino- group, a NH2-(C1-C4)alkyl- group, a mono(C1-C4)alkylamino-(C1-C4)alkyl- group, a di(C1- C4)alkylamino-(C1-C4)alkyl- group, NH2-(C3-C6)cycloalkyl- group, a (C2- C5)acylamino-(C1-C4)alkyl- group, a (C2-C5)acylamino- group, a (C2-C5)acyl- group, a hydroxy-(C1-C4)alkyl- group, a SH-(C1-C4)alkyl- group; a CN-(C1- C4)alkyl- group, a (C1-C4)alkoxy-(C1-C4)alkyl- group, a hydroxyl group, an oxo group, a (C3-C6)cycloalkyl group, a halogen atom, a halo(C1-C4)alkyl- group, a cyano group, a NH2-C(=O)- group, a mono(C1-C4)alkylamino-C(=O)- group, a di(C1-C4)alkylamino-C(=O)- group, a NH2-C(=O)-(C1-C4)alkyl- group, a mono(C1-C4)alkylamino-C(=O)-(C1-C4)alkyl- group, or a di(C1-C4)alkylamino- C(=O)-(C1-C4)alkyl- group, in particular R4 and R5 form together with the nitrogen atom to which they are attached: - an azepanyl ring unsubstituted or substituted by one OH-CH2- group; - a morpholino ring unsubstituted or substituted by one or two substituents independently selected from a methyl group, a CH2F- group, NH2-CH2- group, a N(CH3)2- CH2- group, a CH3-NH-(CH2)2- group, a SH-CH2- group, a CN-CH2- group, a OH-CH2- group, a OH-CD2- group, a OH-(CH2)2- group, a OH-C(CH3)2- group, a CH3-CH(OH)- group, a CH3-C(=O)-NH-CH2- group, a CH3-C(=O)-NH-CH2- CH2- group a CH(CH3)2- C(=O)-NH-CH2- group, a NH2-C(=O)- group, a NH(CH3)-C(=O)- group, a N(CH3)2-C(=O)- group, a NH2-cyclopropyl- group, a NH2-C(=O)-CH2- group, a NH(CH3)-C(=O)-CH2- group, a N(CH3)2-C(=O)-CH2- group, a CH3-CH2-C(=O)- group, an oxo group, and a CH3- O-CH2- group, - a thiomorpholino ring unsubstituted or substituted by one to two oxo groups; - a piperidinyl ring unsubstituted or substituted by one to two substituents independently selected from a NH2 group, a NH2-CH2- group, a NH(CH2CH3)- group, a N(CH3)2- group, a NH2-cyclopropyl- group, a N(CH3)2-CH2- group, a OH-CH2- group, a CH3-C(=O)-NH-CH2- group, a cyano group, a hydroxyl group, an oxo group and a fluorine atom, - a pyrrolidinyl ring unsubstituted or substituted by one to two substituents independently selected from a NH2- group, a NH2-CH2- group, a N(CH3)2-CH2- group, a OH-CH2- group, a CH3-O-CH2- group, a hydroxyl group, and an oxo group, - an isoxazolidinyl ring unsubstituted or substituted by one hydroxyl group,- a piperazinyl ring unsubstituted or substituted by one to two substituents independently selected from a methyl group, an oxo group and a OH-CH2- group; - a hexahydropyrimidinyl ring substituted by one oxo group; - an azetidinyl ring unsubstituted or substituted by one OH-CH2- group, - a tetrahydroquinolinyl ring or a dihydroquinolinyl ring such as 3,4-dihydro- 2H-quinolinyl ring, unsubstituted or substituted by one hydroxyl group - a hexahydropyridooxazinyl ring such as a hexahydro-2H-pyrido[3,4- b][1,4]oxazinyl ring, for instance a 3,4a,5,7,8,8a-hexahydro-2H-pyrido[3,4-b][1,4]oxazinyl group, or a hexahydro-2H-pyrido[4,3-b][1,4]oxazin-4-yl ring, for instance a 3,4a,5,7,8,8a- hexahydro-2H-pyrido[4,3-b][1,4]oxazinyl ring, unsubstituted or substituted by one cyclobutyl group, one methyl group, one ethyl group, one 2,2,2-trifluoroethyl group, one 2- fluoroethyl group, one 3-fluoropropyl group, one isopropropyl group or one acetyl group; - a hexahydropyranooxazinyl ring such as hexahydro-2H-pyrano[3,4- b][1,4]oxazinyl ring, for instance a 3,4a,5,7,8,8a-hexahydro-2H-pyrano[3,4-b][1,4]oxazinyl group, or such as a hexahydro-2H-pyrano[4,3-b][1,4]oxazinyl ring, for instance a 3,4a,5,7,8,8a-hexahydro-2H-pyrano[4,3-b][1,4]oxazinyl ring, unsubstituted; - a dihydropyridooxazinyl ring such as dihydropyrido[3,4-b][1,4]oxazinyl ring or dihydropyrido[4,3-b][1,4]oxazinyl ring, for instance 2,3-dihydropyrido[3,4- b][1,4]oxazinyl ring or 2,3-dihydropyrido[4,3-b][1,4]oxazinyl ring, unsubstituted; - a dihydropyrazolooxazinyl ring such as dihydro-2H-pyrazolo[4,3- b][1,4]oxazinyl ring, for instance 5,6-dihydro-2H-pyrazolo[4,3-b][1,4]oxazinyl ring, unsubstituted; - a dihydrobenzoxazinyl ring such as dihydro-1,4-benzoxazinyl ring, for instance 2,3-dihydro-1,4-benzoxazinyl ring substituted by one hydroxyl group; - a tetrahydronaphthyridinyl ring or a dihydronaphthyridinyl ring such as 3,4- dihydro-2H-1,6-naphthyridinyl ring substituted by one hydroxyl group; - a hexahydronaphthyridinyl ring such as hexahydro-2H-1,7-naphthyridinyl ring for instance a 3,4,4a,5,6,8a-hexahydro-2H-1,7-naphthyridinyl ring substituted by one methyl group and one oxo group; - a octahydronaphthyridinyl ring such as octahydro-1,7-naphthyridinyl ring or octahydro-1,5-naphthyridinyl ring for instance a 2,3,4,4a,5,6,7,8a-octahydro-1,7- naphthyridinyl ring, a 2,3,4,4a,5,6,8,8a-octahydro-1,7-naphthyridinyl ring, or a2,3,4,4a,6,7,8,8a-octahydro-1,5-naphthyridinyl ring, substituted by one oxo group, one methyl group, or one acetyl group; - an octahydropyrrolopyridinyl ring or a hexahydropyrrolopyridinyl ring such as hexahydro-1H-pyrrolo[3,4-c]pyridinyl ring, octahydropyrrolo[2,3-c]pyridinyl ring, or hexahydro-2H-pyrrolo[2,3-c]pyridinyl ring, for instance 2,3,3a,6,7,7a-hexahydro-1H- pyrrolo[3,4-c]pyridinyl ring, 2,3,3a,4,5,6,7,7a-octahydropyrrolo[2,3-c]pyridinyl ring or 3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridinyl ring, unsubstituted or substituted by one methyl group, one ethyl group, one acetyl group, one isopropyl group or one oxo group ; - an octahydropyrrolooxazinyl ring or a hexahydropyrrolooxazinyl ring such as hexahydro-2H-pyrrolo[3,4-b][1,4]oxazinyl ring, for instance 2,3,4a,5,7,7a-hexahydro-2H- pyrrolo[3,4-b][1,4]oxazinyl ring, 3,4,4a,5,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazinyl ring or 3,4a,5,6,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazinyl ring, unsubstituted or substituted by one methyl group, one ethyl group or one acetyl group; - a hexahydrocyclopentaoxazinyl ring such as 3,4a,5,6,7,7a-hexahydro-2H- cyclopenta[b][1,4]oxazinyl ring substituted by one hydroxyl group; - an octahydropyridooxazinyl ring such as octahydropyrido[4,3-b][1,4]oxazinyl ring, for instance 2,3,4a,5,6,7,8,8a-octahydropyrido[4,3-b][1,4]oxazinyl ring, unsubstituted; - an indolinyl ring substituted by one hydroxyl group or one -CH2OH group; - a hexahydropyrrolopyrrolyl ring such as hexahydropyrrolo[3,4-b]pyrrolyl ring, hexahydro-1H-pyrrolo[3,2-b]pyrrolyl ring, or hexahydro-2H-pyrrolo[3,4-b]pyrrolyl ring, for instance 2,3,3a,4,6,6a-hexahydropyrrolo[3,4-b]pyrrolyl ring, 2,3,3a,5,6,6a-hexahydro- 1H-pyrrolo[3,2-b]pyrrolyl ring, or a 3,3a,4,5,6,6a-hexahydro-2H-pyrrolo[3,4-b]pyrrolyl ring unsubstituted or substituted by one methyl group, one ethyl group or one acetyl group; - a hexahydrofuropyrrolyl ring such as hexahydrofuro[3,4-c]pyrrolyl ring for instance 1,3,3a,4,6,6a-hexahydrofuro[3,4-c]pyrrolyl ring, unsubstituted; - a azabicyclooctanyl ring such as 6-azabicyclo[3.2.1]octanyl ring substituted by one hydroxyl group ; - a diazabicyclononanyl ring such as 3,6-diazabicyclo[3.2.2]nonanyl ring substituted by one methyl group - a oxaazabicyclooctanyl ring such as 3-oxa-8-azabicyclo[3.2.1]octanyl ring unsubstituted ;- an azaspirononanyl ring such as an azaspiro[3.5]nonanyl ring, unsubstituted or substituted by one substituent selected from a NH2 group, a CH3-C(=O)-NH- group, and a hydroxyl group; - an azaspirooctanyl ring such as an azaspiro[3.4]octanyl ring, unsubstituted or substituted by one hydroxyl group; - an azaspiroheptanyl ring such as an azaspiro[3.3]heptanyl ring, unsubstituted or substituted by one hydroxyl group; - a diazaspirodecanyl ring such as 1,9-diazaspiro[4.5]decanyl ring substituted by one methyl group; - a diazaspirononanyl ring such as a diazaspiro[3.5]nonanyl ring, unsubstituted or substituted by one methyl group; - a diazaspiroheptanyl ring such as a diazaspiro[3.3]heptanyl ring, unsubstituted or substituted by one a methyl group; - an oxadiazaspirononanyl ring such as 8-oxa-2,5-diazaspiro[3.5]nonanyl ring substituted by one methyl group; - an oxadiazaspirodecanyl ring such as 2-oxa-6,9-diazaspiro[4.5]decanyl ring, 9- oxa-2,6-diazaspiro[4.5]decanyl ring, or 6-oxa-2,9-diazaspiro[4.5]decanyl ring unsubstituted or substituted by one ethyl group or one methyl group; - an oxadiazaspiroundecanyl ring such as 4-oxa-1,8-diazaspiro[5.5]undecanyl ring substituted by one methyl group; - an dioxadiazaspirododecanyl ring such as 1,11-dioxa-4,8- diazaspiro[5.6]dodecanyl ring substituted by one ethyl group; - an oxaazaspirononanyl ring such as a oxaazaspiro[3.5]nonanyl ring; and - an oxaazaspiroheptanyl ring such as an oxaazaspiro[3.3]heptanyl ring.

9. A compound of formula (I) or a pharmaceutically acceptable salt thereof according any one of claims 1 to 8, said compound being chosen from: (1) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]piperidin-4-ol; (2) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]piperidine-4-carbonitrile; (3) 7-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-7-azaspiro[3.5]nonan-2-ol; (4) 3,5-dimethyl-2-[6-[rac-(4aS,8aR)-6-cyclobutyl-3,4a,5,7,8,8a-hexahydro-2H- pyrido[3,4-b][1,4]oxazin-1-yl]pyridazin-3-yl]phenol;(5) 2-[6-[(3R)-3-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (6) 2-[6-[(3S)-3-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (7) 2-[6-(2,7-diazaspiro[3.5]nonan-7-yl)pyridazin-3-yl]-3,5-dimethyl-phenol;2,2,2- trifluoroacetic acid; (8) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (9) 2-[6-[(2R)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (10) 2-[6-[(4aR,8aS)-6-cyclobutyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4] oxazin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol Enantiomer 1; (11) 2-[6-[(4aS,8aR)-6-cyclobutyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4] oxazin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; formic acid Enantiomer 2; (12) 2-[6-[(4aR,8aS)-6-cyclobutyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4] oxazin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol Enantiomer 1; (13) 2-[6-[(4aS,8aR)-6-cyclobutyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4] oxazin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol Enantiomer 2; (14) 2-[6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol; (15) 2-[6-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol; (16) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol; (17) 2-[6-[3-(1-aminocyclopropyl)-1-piperidyl]pyridazin-3-yl]-3,5-dichloro-phenol; (18) 2-[6-[(3S)-3-(aminomethyl)-1-piperidyl]pyridazin-3-yl]-3,5-dichloro-phenol; (19) 2-[6-[4-(aminomethyl)-1-piperidyl]pyridazin-3-yl]-3,5-dichloro-phenol; (20) 2-[6-[(3S)-3-(hydroxymethyl)pyrrolidin-1-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol; (21) 3,5-dichloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]phenol; (22) 2-[6-[(3R)-3-(aminomethyl)-1-piperidyl]pyridazin-3-yl]-3,5-dichloro-phenol; (23) 2-[6-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]pyridazin-3-yl]-3,5-dichloro-phenol; (24) 2-[6-[2-[(dimethylamino)methyl]morpholin-4-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol; (25) 2-[6-[(3R)-3-(aminomethyl)pyrrolidin-1-yl]pyridazin-3-yl]-3,5-dichloro-phenol;(26) 2-[6-[2-(1-hydroxy-1-methyl-ethyl)morpholin-4-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol; (27) 2-[6-[(2R)-2-[(dimethylamino)methyl]morpholin-4-yl]pyridazin-3-yl]-3-methyl- 5-(trifluoromethyl)phenol; (28) 2-[6-[(3S)-3-(hydroxymethyl)-1-piperidyl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol; (29) 3-methyl-2-[6-(4-methylpiperazin-1-yl)pyridazin-3-yl]-5-(trifluoromethyl) phenol; (30) 2-[6-[3-(hydroxymethyl)azetidin-1-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol; (31) 2-[6-[(3R)-3-amino-1-piperidyl]pyridazin-3-yl]-3,5-dimethyl-phenol;formic acid; (32) 2-[6-(2-amino-7-azaspiro[3.5]nonan-7-yl)pyridazin-3-yl]-3,5-dichloro-phenol; (33) 3,5-dichloro-2-[6-[(2R)-2-(methoxymethyl)morpholin-4-yl]pyridazin-3-yl]phenol; (34) 3,5-dichloro-2-[6-[(3S)-3-(hydroxymethyl)-1-piperidyl]pyridazin-3-yl]phenol; (35) 3,5-dichloro-2-[6-[(2S)-2-(methoxymethyl)morpholin-4-yl]pyridazin-3-yl]phenol; (36) 3,5-dichloro-2-[6-[(3R)-3-(hydroxymethyl)-1-piperidyl]pyridazin-3-yl]phenol; (37) 7-[6-(2,4-dichloro-6-hydroxy-phenyl)pyridazin-3-yl]-7-azaspiro[3.5]nonan-2-ol; (38) 3,5-dichloro-2-(6-morpholinopyridazin-3-yl)phenol; (39) 3,5-dichloro-2-[6-[(2S)-2-[(dimethylamino)methyl]morpholin-4-yl]pyridazin-3- yl]phenol; (40) 3,5-dichloro-2-[6-[(3S)-3-[(dimethylamino)methyl]pyrrolidin-1-yl]pyridazine-3- yl]phenol; (41) 3,5-dichloro-2-[6-[(3R)-3-[(dimethylamino)methyl]pyrrolidin-1-yl]pyridazin-3- yl]phenol; (42) 6-[6-(2,4-dichloro-6-hydroxy-phenyl)pyridazin-3-yl]-6-azaspiro[3.4]octan-2-ol; (43) 3,5-dichloro-2-[6-[(2R)-2-[(dimethylamino)methyl]morpholin-4-yl]pyridazin-3- yl]phenol; (44) 3-fluoro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]phenol; (45) 3-fluoro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-5-methyl- phenol; (46) 2-[6-(2,4-dichloro-6-hydroxy-phenyl)pyridazin-3-yl]-2-azaspiro[3.3]heptan-6-ol; (47) N-[7-[6-(2,4-dichloro-6-hydroxy-phenyl)pyridazin-3-yl]-7-azaspiro[3.5]nonan-2- yl]acetamide;(48) 3-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]phenol; (49) 3,5-dichloro-2-[6-(4,4-difluoro-1-piperidyl)pyridazin-3-yl]phenol; (50) 3,5-dichloro-2-[6-[(3R)-3-[(dimethylamino)methyl]-1-piperidyl]pyridazin-3- yl]phenol; (51) 3,5-dichloro-2-[6-[(3S)-3-[(dimethylamino)methyl]-1-piperidyl]pyridazin-3- yl]phenol; (52) 2-[6-[2-(1-hydroxy-1-methyl-ethyl)morpholin-4-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol Enantiomer 1; (53) 2-[6-[-2-(1-hydroxy-1-methyl-ethyl)morpholin-4-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol Enantiomer 2; (54) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3- (trifluoromethyl)phenol; (55) 3,5-dichloro-2-[6-(2-methyl-2,7-diazaspiro[3.5]nonan-7-yl)pyridazin-3-yl]phenol; (56) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3-methyl-phenol; (57) N-[[(3R)-1-[6-(2,4-dichloro-6-hydroxy-phenyl)pyridazin-3-yl]-3-piperidyl] methyl]acetamide; (58) N-[[(3S)-1-[6-(2,4-dichloro-6-hydroxy-phenyl)pyridazin-3-yl]-3- piperidyl]methyl]acetamide; (59) 2-[6-[-2-[(dimethylamino)methyl]morpholin-4-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol Enantiomer 1; (60) 2-[6-[-2-[(dimethylamino)methyl]morpholin-4-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol Enantiomer 2; (61) 1-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3-yl]pyrrolidin-2- one; (62) (4S)-4-hydroxy-1-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3- yl]pyrrolidin-2-one; (63) 5-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3-methyl- phenol; (64) 3,5-dichloro-2-[6-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyridazin-3-yl]phenol; (65) 2-[6-[(3R)-3-(hydroxymethyl)pyrrolidin-1-yl]pyridazin-3-yl]-3,5-dimethyl- phenol; (66) 3,5-dichloro-2-[6-(2-oxa-7-azaspiro[3.5]nonan-7-yl)pyridazin-3-yl]phenol;(67) (3S)-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]piperidin-3-ol; (68) 2-[6-[(3S)-3-(ethylamino)-1-piperidyl]pyridazin-3-yl]-3,5-dimethyl-phenol; (69) 2-[6-[(3S)-3-amino-1-piperidyl]pyridazin-3-yl]-3,5-dimethyl-phenol; (70) (3R)-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]pyrrolidin-3-ol; (71) (3S)-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]pyrrolidin-3-ol; (72) 2-[4-ethyl-6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-5-methyl- phenol; (73) 5-chloro-2-[4-ethyl-6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3- yl]phenol; (74) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-isopropyl-pyridazin-3-yl]-5- methyl-phenol; (75) 5-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-isopropyl-pyridazin-3- yl]phenol; (76) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-methyl-pyridazin-3-yl]-5-methyl- phenol; (77) 2-[4-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-6,7-dihydro-5H- cyclopenta[d]pyridazin-1-yl]-5-methyl-phenol; (78) 5-chloro-2-[4-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-6,7-dihydro-5H- cyclopenta[d]pyridazin-1-yl]phenol; (79) 2-[6-[(3S)-3-(hydroxymethyl)pyrrolidin-1-yl]pyridazin-3-yl]-3,5-dimethyl- phenol; (80) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4,5-dimethyl-pyridazin-3-yl]-5- methyl-phenol; (81) 5-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4,5-dimethyl-pyridazin-3- yl]phenol; (82) 2-[6-[(3S)-3-(methoxymethyl)pyrrolidin-1-yl]pyridazin-3-yl]-3,5-dimethyl- phenol; (83) 2-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-2-azaspiro[3.5]nonan-7-ol; (84) 2-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-2-azaspiro[3.4]octan-6-ol; (85) 5-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-methyl-pyridazin-3- yl]phenol;(86) (4S)-4-hydroxy-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]pyrrolidin- 2-one; (87) 2-[6-[(2R)-2-(aminomethyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl- phenol;2,2,2-trifluoroacetic acid; (88) 2-[6-[(3R)-3-(methoxymethyl)pyrrolidin-1-yl]pyridazin-3-yl]-3,5-dimethyl- phenol; (89) 2-[6-[(2R)-2-(aminomethyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl- phenol;2,2,2-trifluoroacetic acid; (90) 6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-3-(2-hydroxy-4-methyl- phenyl)pyridazine-4-carbonitrile; (91) 3,5-dimethyl-2-[6-(1-methyl-1,6-diazaspiro[3.3]heptan-6-yl)pyridazin-3- yl]phenol; (92) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-5-methyl-phenol; (93) 5-fluoro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-methyl-pyridazin-3- yl]phenol; (94) 2-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-2-azaspiro[3.4]octan-6-ol Enantiomer 1; (95) 2-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-2-azaspiro[3.4]octan-6-ol Enantiomer 2; (96) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-5-methoxy-3- methyl-phenol; (97) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-methyl-pyridazin-3-yl]-5- (trifluoromethyl)phenol; (98) 2-[6-[2-[(1S)-1-hydroxyethyl]morpholin-4-yl]pyridazin-3-yl]-3,5-dimethylphenol Diastereoisomer 2; (99) 2-[6-[2-[(1S)-1-hydroxyethyl]morpholin-4-yl]pyridazin-3-yl]-3,5-dimethylphenol Diastereoisomer 1; (102) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-4-methyl-phenol; (103) 3-(4-chloro-2-hydroxy-phenyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4- yl]pyridazine-4-carbonitrile; (105) N-[[(2S)-4-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]morpholin-2- yl]methyl]acetamide;(106) N-[[(2R)-4-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]morpholin-2- yl]methyl]acetamide; (107) 2-[6-[3-(hydroxymethyl)azepan-1-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (108) 2-[6-[2-[(1R)-1-hydroxyethyl]morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl- phenol Diastereoisomer 1; (109) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-5-methyl-pyridazin-3-yl]-3,5- dimethyl-phenol; (110) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-5-methyl-pyridazin-3-yl]-5-methyl- phenol; (111) 2-[6-[rac-(4aS,8aS)-3,4a,5,7,8,8a-hexahydro-2H-pyrano[3,4-b][1,4]oxazin-1- yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (112) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-methyl-pyridazin-3-yl]-3,5- dimethyl-phenol; (113) (4R)-2-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]isoxazolidin-4-ol (114) 2-[6-[1-(hydroxymethyl)-6-azabicyclo[3.2.1]octan-6-yl]pyridazin-3-yl]-3,5- dimethyl-phenol; (115) 2-[6-[(2S)-2-(hydroxymethyl)azetidin-1-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (116) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-methyl-pyridazin-3-yl]-5- methoxy-phenol; (117) 3,5-dichloro-2-[6-[(2S)-2-(hydroxymethyl)azetidin-1-yl]pyridazin-3-yl]phenol; (118) 2-[6-[(2R)-2-(hydroxymethyl)azetidin-1-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (119) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-methyl-pyridazin-3-yl]-5- methoxy-3-methyl-phenol; (120) 3,5-dimethyl-2-[6-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)pyridazin-3-yl]phenol; (121) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethoxy)phenol; (122) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-3-(hydroxymethyl) pyrrolidin-2-one; (123) 2-[6-[(3R)-3-(aminomethyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol, 2,2,2-trifluoroacetic acid; (124) 2-[6-[(3S)-3-(aminomethyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol;(125) 2-[6-[(4aR,7aR)-3,4,4a,5,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazin-6- yl]pyridazin-3-yl]-3,5-dimethylphenol; (126) 1-[4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]morpholin-2-yl]propan-1- one; (127) 5-chloro-2-[6-[(3S)-3-(hydroxymethyl)pyrrolidin-1-yl]pyridazin-3-yl]-3-methyl- phenol; (128) 2-[6-[(3S)-3-(dimethylamino)-1-piperidyl]pyridazin-3-yl]-3,5-dimethyl-phenol; (129) N-[[(3R)-4-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]morpholin-3-yl] methyl]acetamide; (130) (4S)-1-[6-(4-chloro-2-hydroxy-6-methyl-phenyl)pyridazin-3-yl]-4-hydroxy- pyrrolidin-2-one; (131) (4S)-4-amino-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]pyrrolidin-2- one; (132) (4R)-4-hydroxy-1-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3- yl]pyrrolidin-2-one; (133) 5-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-5-methyl-pyridazin-3-yl]- 3-methyl-phenol; (134) 5-(difluoromethyl)-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]- 3-methyl-phenol; (135) 2-[6-[(2S)-2-(1-aminocyclopropyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl- phenol; (136) 2-[6-[(2R)-2-(1-aminocyclopropyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl- phenol; (137) (4R)-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-4-(hydroxymethyl) pyrrolidine-2-one; (138) (4S)-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-4-(hydroxymethyl) pyrrolidin-2-one; (139) (3R)-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-3- (hydroxymethyl)pyrrolidin-2-one; (140) (3S)-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-3- (hydroxymethyl)pyrrolidin-2-one; (141) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3,6-dimethylphenol;(142) 2-[(2R)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]morpholin-2-yl]-N- methylacetamide; (143) 2-[(2S)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]morpholin-2-yl]-N- methylacetamide; (144) 2-[4-(difluoromethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]- 5-methyl-phenol; (145) 5-chloro-2-[4-(difluoromethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4-yl] pyridazin-3-yl]phenol; (146) 2-[(2R)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]morpholin-2-yl] acetamide; (147) 2-[(2S)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]morpholin-2-yl] acetamide; (148) 2-[6-[(3R)-3-(dimethylamino)-1-piperidyl]pyridazin-3-yl]-3,5-dimethyl-phenol; (149) 5-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-methyl-pyridazin-3-yl]- 3-methyl-phenol; (150) 2-[(2R)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]morpholin-2-yl]- N,N-dimethylacetamide; (151) 2-[(2S)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]morpholin-2-yl]- N,N-dimethylacetamide; (152) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-4,6-dimethylphenol; (153) 3-(difluoromethyl)-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]- 5-methyl-phenol; (154) 3,5-dimethyl-2-[6-[rac-(4aR,8aS)-3,4a,5,7,8,8a-hexahydro-2H-pyrano[3,4- b][1,4]oxazin-1-yl]pyridazin-3-yl]phenol; (155) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-(trifluoromethyl)pyridazin-3-yl]- 5-methyl-phenol; (156) 1-[(2R)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]morpholin-2-yl] propan-1-one; (157) 1-[(2S)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]morpholin-2-yl] propan-1-one; (158) 6-(2-hydroxy-4,6-dimethyl-phenyl)-3-[(2S)-2-(hydroxymethyl)morpholin-4-yl] pyridazine-4-carbonitrile;(159) 3-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazine-4-carbonitrile; (160) 5-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-(trifluoromethyl) pyridazine-3-yl]phenol; (161) 3,5-dichloro-2-[6-[2-(fluoromethyl)morpholin-4-yl]pyridazin-3-yl]phenol; (162) 4-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-2,3-dihydro-1,4- benzoxazin-6-ol; (163) 6-(4-chloro-2-hydroxy-6-methyl-phenyl)-3-[(2S)-2-(hydroxymethyl)morpholin-4- yl]pyridazine-4-carbonitrile; (164) N-[[(3S)-1-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3-yl]-3- piperidyl]methyl]acetamide; (165) 2-[6-[(2S)-2-[dideuterio(hydroxy)methyl]morpholin-4-yl]pyridazin-3-yl]-3,5- dimethylphenol; (166) (2S)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]-N-methylmorpholine- 2-carboxamide; (167) N-[[(3R)-1-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3-yl]-3- piperidyl]methyl]acetamide; (168) 2-[6-[(4aR,7aR)-4-ethyl-2,3,4a,5,7,7a-hexahydropyrrolo[3,4-b][1,4]oxazin-6-yl] pyridazin-3-yl]-3,5-dimethylphenol; (169) 5-chloro-2-[6-[(2S)-2-[dideuterio(hydroxy)methyl]morpholin-4-yl]pyridazin-3-yl] -3-methylphenol; (170) 2-[5-(difluoromethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]- 3,5-dimethyl-phenol; (171) 5-chloro-2-[5-(difluoromethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4- yl]pyridazin-3-yl]-3-methyl-phenol; (172) 3-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-5-methyl- phenol; (173) 2-[6-[(2R,6S)-2,6-bis(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3,5- dimethyl-phenol; (174) 2-[6-[2-(fluoromethyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (175) 6-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-6-azaspiro[3.5]nonan-2-ol Isomer 1;(176) 6-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-6-azaspiro[3.5]nonan-2-ol Isomer 2; (177) 3-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-methyl-pyridazin-3-yl]- 5-methyl-phenol; (178) 2-[6-[(2R,6S)-2,6-bis(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol; (179) (4S)-2-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]isoxazolidin-4-ol; (180) 2-[6-[2-[(1R)-1-hydroxyethyl]morpholin-4-yl]pyridazin-3-yl]-3,5-dimethylphenol Diastereoisomer 2; (181) (2S)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]morpholine-2- carboxamide; (182) (2R)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]-N-methylmorpholine- 2-carboxamide; (183) (2R)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]morpholine-2- carboxamide; (184) (2R)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]-N,N- dimethylmorpholine-2-carboxamide; (185) 2-[6-[(4aS,7aS)-3,4,4a,5,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazin-6- yl]pyridazin-3-yl]-3,5-dimethylphenol; (186) 2-[4-(hydroxymethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]- 3,5-dimethyl-phenol; (187) 2-[5-(hydroxymethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]- 3,5-dimethyl-phenol; (188) 5-chloro-2-[4-(hydroxymethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4- yl]pyridazin-3-yl]-3-methyl-phenol; (189) 5-chloro-2-[5-(hydroxymethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4- yl]pyridazin-3-yl]-3-methyl-phenol; (190) 2-[6-[rac-(4aR,7aR)-3,4a,5,6,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazin-4- yl]pyridazin-3-yl]-3,5-dimethylphenol; (191) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3,4-dimethylphenol; (192) 2-[6-[(2S)-2-[dideuterio(hydroxy)methyl]morpholin-4-yl]pyridazin-3-yl]-3- methyl-5-(trifluoromethyl)phenol;(193) 4-[6-(4-chloro-2-hydroxy-6-methyl-phenyl)pyridazin-3-yl]-2,3-dihydro-1,4- benzoxazin-7-ol; (194) 2-[5-(difluoromethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]- 3-methyl-5-(trifluoromethyl)phenol; (195) 2-[6-[rac-(4aR,8aS)-2,3,4a,5,6,7,8,8a-octahydropyrido[4,3-b][1,4]oxazin-4- yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (196) 3,5-dimethyl-2-[6-(2-oxa-6,9-diazaspiro[4.5]decan-9-yl)pyridazin-3-yl]phenol; (197) 2-[6-[rac-(4aR,8aS)-2,3,4a,5,6,7,8,8a-octahydropyrido[4,3-b][1,4]oxazin-4- yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (198) 2-[6-[(2S,6S)-2,6-bis(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3,5- dimethyl-phenol; (199) 2-[6-[(2S,6S)-2,6-bis(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol; (200) 2-[6-[(2R,6R)-2,6-bis(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol; (201) 2-[6-[(2R,6R)-2,6-bis(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3,5- dimethyl-phenol; (203) 3,5-dichloro-2-(6-thiomorpholinopyridazin-3-yl)phenol; (204) 5-cyclopropyl-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3- methyl-phenol; (206) 2-[6-[(3aS,6aR)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]pyrrol-5-yl]pyridazin-3-yl]- 3,5-dimethyl-phenol; (207) 2-[6-[(3aR,6aR)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]pyrrol-5-yl]pyridazin-3-yl]- 3,5-dimethyl-phenol; (208) 2-[6-(8-ethyl-1,11-dioxa-4,8-diazaspiro[5.6]dodecan-4-yl)pyridazin-3-yl]-3,5- dimethylphenol; (209) 2-[6-[rac-(4aR,8aS)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin -4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (210) 2-[6-[rac-(4aR,8aS)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin -4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (211) N-[[(3S)-1-[6-(4-chloro-2-hydroxy-6-methyl-phenyl)pyridazin-3-yl]-3-piperidyl] methyl]acetamide;(212) N-[[(3R)-1-[6-(4-chloro-2-hydroxy-6-methyl-phenyl)pyridazin-3-yl]-3-piperidyl] methyl]acetamide; (213) 1-[rac-(4aR,8aS)-4-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]- 3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-6-yl]ethanone; (214) 1-[rac-(4aR,8aS)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin- 3-yl]-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-6- yl]ethanone; (215) 2-[6-(2,3-dihydropyrido[3,4-b][1,4]oxazin-1-yl)pyridazin-3-yl]-3,5-dimethyl- phenol; (216) N-[[(2R)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3- yl]morpholin-2-yl]methyl]acetamide; (217) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-3,4-dihydro-2H-quinolin-7- ol; (219) 2-[6-[(2S)-2-(fluoromethyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (220) 2-[6-[(2R)-2-(fluoromethyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (221) 2-[6-[rac-(4aR,8aS)-2,3,4a,5,6,7,8,8a-octahydropyrido[4,3-b][1,4]oxazin-4- yl]pyridazin-3-yl]-5-chloro-3-methyl-phenol; (222) 1-[rac-(4aR,8aS)-4-[6-(4-chloro-2-hydroxy-6-methyl-phenyl)pyridazin-3-yl]- 3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-6-yl]ethanone; (223) 2-[6-[rac-(4aR,8aS)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-5-chloro-3-methyl-phenol; (224) 2-[6-[rac-(4aR,8aS)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4] oxazin-4-yl]pyridazin-3-yl]-5-chloro-3-methyl-phenol; (225) 2-[6-[rac-(4aR,8aS)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (226) 2-[6-[rac-(4aR,8aS)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (227) 2-[6-(6-ethyl-2-oxa-6,9-diazaspiro[4.5]decan-9-yl)pyridazin-3-yl]-3,5- dimethylphenol; (228) 1-[rac-(3aS,6aS)-1-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin- 3-yl]-2,3,3a,4,6,6a-hexahydropyrrolo[3,4-b]pyrrol-5-yl]ethanone;(229) 2-[6-[rac-(3aS,6aS)-3,3a,4,5,6,6a-hexahydro-2H-pyrrolo[3,4-b]pyrrol-1- yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (230) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-3,4-dihydro-2H-quinolin-6- ol; (231) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-3,4-dihydro-2H-quinolin-8- ol; (232) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-3,4-dihydro-2H-quinolin-5- ol; (233) 2-[6-[(2R)-2-(2-hydroxyethyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl- phenol; (234) 2-[6-[(2S)-2-(2-hydroxyethyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl- phenol; (235) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-5-(hydroxymethyl) piperidin-2-one; (236) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]indolin-5-ol; (237) 3,5-dichloro-2-[6-[(2R)-2-(fluoromethyl)morpholin-4-yl]pyridazin-3-yl]phenol; (238) 3,5-dichloro-2-[6-[(2S)-2-(fluoromethyl)morpholin-4-yl]pyridazin-3-yl]phenol; (239) 1-[6-(2,4-dichloro-6-hydroxy-phenyl)pyridazin-3-yl]hexahydropyrimidin-2-one; (240) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]indolin-4-ol; (241) 2-[6-[4-(hydroxymethyl)indolin-1-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (242) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-3,4-dihydro-2H-1,6- naphthyridin-5-ol; (243) 2-[6-[rac-(3aS,6aS)-5-ethyl-2,3,3a,4,6,6a-hexahydropyrrolo[3,4-b]pyrrol-1- yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (245) 5-ethyl-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3- methylphenol; (246) 3-ethyl-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-5- methylphenol; (247) 2-[4-(difluoromethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]- 5-(trifluoromethyl)phenol; (248) 2-[4-(difluoromethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]- 3-methyl-5-(trifluoromethyl)phenol;(249) 5-chloro-2-[4-(difluoromethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4- yl]pyridazin-3-yl]-3-methyl-phenol; (250) (4S)-4-amino-1-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3- yl]pyrrolidin-2-one; (251) 2-[6-[(4aR,8aS)-2,3,4a,5,6,7,8,8a-octahydropyrido[4,3-b][1,4]oxazin-4- yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (252) 2-[6-[(4aS,8aR)-2,3,4a,5,6,7,8,8a-octahydropyrido[4,3-b][1,4]oxazin-4- yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (253) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]indolin-7-ol; (254) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]indolin-6-ol; (255) 2-[6-[(4aR,8aS)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-4- yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (256) 2-[6-[(4aS,8aR)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-4- yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (257) 1-[rac-(4aS,7aS)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]- 2,3,4a,5,7,7a-hexahydropyrrolo[3,4-b][1,4]oxazin-6-yl]ethanone; (258) 3-methyl-2-[6-[(2R)-2-methylmorpholin-4-yl]pyridazin-3-yl]-5- (trifluoromethyl)phenol; (259) 3-methyl-2-[6-[(2S)-2-methylmorpholin-4-yl]pyridazin-3-yl]-5- (trifluoromethyl)phenol; (260) 2-[6-[(4aR,8aS)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin- 4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (261) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin- 4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (262) 1-[(4aR,8aS)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3- yl]-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-6-yl]ethanone; (263) 1-[(4aS,8aR)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3- yl]-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-6-yl]ethanone; (264) rac-(3aS,7aR)-5-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3- yl]-2,3,3a,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin-4-one, hydrochloride;(265) 2-[6-[rac-(3aS,6aS)-5-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[3,4-b]pyrrol-1- yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (266) 2-[6-[(2R)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol; (267) N-[[(2R)-4-[6-(4-chloro-2-hydroxy-6-methyl-phenyl)pyridazin-3-yl]morpholin-2- yl]methyl]acetamide; (268) 2-[6-[(4aR,8aS)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin- 4-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-(trifluoromethyl)phenol; (269) rac-(3aS,7aS)-5-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3- yl]-2,3,3a,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin-4-one, hydrochloride; (270) 2-[6-[(3aR,6aR)-5-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[3,4-b]pyrrol-1- yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (271) 2-[6-[(3aS,6aS)-5-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[3,4-b]pyrrol-1- yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (272) 2-[6-(3,4-dihydro-2H-quinolin-1-yl)pyridazin-3-yl]-3,5-dimethyl-phenol; (273) 3-(hydroxymethyl)-1-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]piperidin-2-one; (274) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-5-isopropyl-3- methyl-phenol; (275) N-[[(2S)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3- yl]morpholin-2-yl]methyl]acetamide; (276) N-[[(2S)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3- yl]morpholin-2-yl]methyl]-2-methylpropanamide; (277) N-[2-[(2R)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3- yl]morpholin-2-yl]ethyl]acetamide; (278) N-[2-[(2S)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3- yl]morpholin-2-yl]ethyl]acetamide; (279) N-[[(2R)-4-[6-(4-chloro-2-hydroxy-6-methylphenyl)pyridazin-3-yl]morpholin-2- yl]methyl]-2-methylpropanamide; and (280) N-[[(2S)-4-[6-(4-chloro-2-hydroxy-6-methylphenyl)pyridazin-3-yl]morpholin-2- yl]methyl]acetamide.(283) 2-[6-[(2R)-2-(fluoromethyl)morpholin-4-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol; (284) 2-[6-[(2S)-2-(fluoromethyl)morpholin-4-yl]pyridazin-3-yl]-3-methyl-5- (trifluoromethyl)phenol; (285) N-[[(2S)-4-[6-(4-chloro-2-hydroxy-6-methylphenyl)pyridazin-3- yl]morpholin-2-yl]methyl]-2-methylpropanamide; (286) (4S)-4-hydroxy-1-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]piperidin-2-one; (287) (3R)-3-(hydroxymethyl)-1-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]piperidin-2-one; (288) (3S)-3-(hydroxymethyl)-1-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]piperidin-2-one; (289) 3-methyl-2-[6-[rac-(4aR,7aR)-6-methyl-2,3,4a,5,7,7a- hexahydropyrrolo[3,4-b][1,4]oxazin-4-yl]pyridazin-3-yl]-5-(trifluoromethyl)phenol; (290) (4aR,8aR)-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-7-methyl- 3,4,4a,5,6,8a-hexahydro-2H-1,7-naphthyridin-8-one; (291) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-5-(difluoromethyl)pyridazin-3-yl]-3,5-dimethyl-phenol; (292) (4R)-4-(hydroxymethyl)-1-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]piperidin-2-one; (293) (4S)-4-(hydroxymethyl)-1-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]piperidin-2-one; (295) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-methyl-phenol; (296) 2-[6-[(2S,6R)-2-(hydroxymethyl)-6-methyl-morpholin-4-yl]pyridazin-3-yl]- 3-methyl-5-(trifluoromethyl)phenol; (297) 2-[6-[(2S,6S)-2-(hydroxymethyl)-6-methyl-morpholin-4-yl]pyridazin-3-yl]- 3-methyl-5-(trifluoromethyl)phenol; (298) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-(trifluoromethyl)phenol; (299) 2-[6-[(4aR,8aS)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-methyl-phenol;(300) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-2,3,4,4a,5,6,7,8a- octahydro-1,7-naphthyridin-8-one; (301) 2-[6-[(4aR,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (302) 2-[6-[(2R,6R)-2-(hydroxymethyl)-6-methyl-morpholin-4-yl]pyridazin-3-yl]- 3-methyl-5-(trifluoromethyl)phenol; (303) 3,5-dimethyl-2-[6-[(2S)-2-(sulfanylmethyl)morpholin-4-yl]pyridazin-3- yl]phenol; (304) 1-[rac-(4aR,8aS)-4-[6-(4-chloro-2-hydroxy-6-methyl-phenyl)pyridazin-3- yl]-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-6-yl]ethanone; (305) 3,5-dimethyl-2-[6-[(2R)-2-(sulfanylmethyl)morpholin-4-yl]pyridazin-3- yl]phenol; (306) 2-[6-[(4aR,8aS)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-methyl-phenol; (307) 5-chloro-3-methyl-2-[6-[rac-(4aR,8aS)-6-methyl-3,4a,5,7,8,8a-hexahydro- 2H-pyrido[4,3-b][1,4]oxazin-4-yl]pyridazin-3-yl]phenol; (308) 2-[6-[(4aR,8aS)-2,3,4a,5,6,7,8,8a-octahydropyrido[4,3-b][1,4]oxazin-4- yl]pyridazin-3-yl]-5-chloro-3-methyl-phenol; (309) 2-[6-[(4aS,8aR)-2,3,4a,5,6,7,8,8a-octahydropyrido[4,3-b][1,4]oxazin-4- yl]pyridazin-3-yl]-5-chloro-3-methyl-phenol; (310) 2-[6-[(4aR,8aS)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (311) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (312) 2-[6-[(4aR,8aS)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-5-chloro-3-methyl-phenol; (313) 2-[6-[(4aS,8aR)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-5-chloro-3-methyl-phenol; (314) 2-[6-[(4aR,8aS)-2,3,4a,5,6,7,8,8a-octahydropyrido[4,3-b][1,4]oxazin-4- yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (315) 2-[6-[(4aS,8aR)-2,3,4a,5,6,7,8,8a-octahydropyrido[4,3-b][1,4]oxazin-4- yl]pyridazin-3-yl]-3,5-dimethyl-phenol;(316) (4R)-4-hydroxy-1-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]piperidin-2-one; (317) 2-[6-(4-ethyl-1,11-dioxa-4,8-diazaspiro[5.6]dodecan-8-yl)pyridazin-3-yl]- 3,5-dimethylphenol; (318) 3-methyl-2-[6-[rac-(4aR,7aR)-3,4a,5,6,7,7a-hexahydro-2H-pyrrolo[3,4- b][1,4]oxazin-4-yl]pyridazin-3-yl]-5-(trifluoromethyl)phenol;hydrochloride; (320) 3-methyl-2-[6-[rac-(4aR,7aS)-3,4a,5,6,7,7a-hexahydro-2H-pyrrolo[3,4- b][1,4]oxazin-4-yl]pyridazin-3-yl]-5-(trifluoromethyl)phenol;hydrochloride; (321) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-5-chloro-3-methyl-phenol; (322) 2-[6-[(4aS,8aR)-2,3,4a,5,6,7,8,8a-octahydropyrido[4,3-b][1,4]oxazin-4-yl]- 4-(difluoromethyl)pyridazin-3-yl]-5-methyl-phenol; (323) 2-[6-[(4aS,8aR)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-methyl-phenol; (324) 5-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-methyl-pyridazin-3- yl]indan-4-ol; (325) (3R)-3-(hydroxymethyl)-1-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]pyrrolidin-2-one; (326) (3S)-3-(hydroxymethyl)-1-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]pyrrolidin-2-one; (327) 2-[(2R)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3- yl]morpholin-2-yl]acetonitrile; (328) 2-[(2S)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3- yl]morpholin-2-yl]acetonitrile; (329) (6R)-4-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-6- (hydroxymethyl)piperazin-2-one; (330) (6S)-4-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-6- (hydroxymethyl)piperazin-2-one; (331) 3-methyl-2-[6-[(2R)-2-[2-(methylamino)ethyl]morpholin-4-yl]pyridazin-3- yl]-5-(trifluoromethyl)phenol; (332) 3-methyl-2-[6-[(2S)-2-[2-(methylamino)ethyl]morpholin-4-yl]pyridazin-3- yl]-5-(trifluoromethyl)phenol;(333) 2-[6-[(4aR,7aS)-6-methyl-2,3,4a,5,7,7a-hexahydropyrrolo[3,4- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (334) 2-[6-[(4aS,7aR)-6-methyl-2,3,4a,5,7,7a-hexahydropyrrolo[3,4- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (335) 1-[rac-(4aR,7aS)-4-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]-2,3,4a,5,7,7a-hexahydropyrrolo[3,4-b][1,4]oxazin- 6-yl]ethanone; (336) 1-[(4aR,8aR)-4-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-6-yl]ethanone; (337) 1-[rac-(4aR,7aR)-4-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]-2,3,4a,5,7,7a-hexahydropyrrolo[3,4-b][1,4]oxazin- 6-yl]ethanone; (338) 5-chloro-2-[6-[(2R)-2-(fluoromethyl)morpholin-4-yl]pyridazin-3-yl]-3- methyl-phenol; (339) 5-chloro-2-[6-[(2S)-2-(fluoromethyl)morpholin-4-yl]pyridazin-3-yl]-3- methyl-phenol; (340) 2-[6-[(rac-3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]-4-methyl-pyridazin-3-yl]-5-(trifluoromethyl)phenol; (341) 2-[6-[(rac-3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]-4-methyl-pyridazin-3-yl]-5-methyl-phenol; (342) 3,5-dimethyl-2-[6-[rac-(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H- pyrrolo[2,3-c]pyridin-1-yl]pyridazin-3-yl]phenol; (343) 2-[6-[(4aS,8aS)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (344) 2-[6-[(4aR,8aR)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (345) 5-[4-(difluoromethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin- 3-yl]indan-4-ol; (346) 3-methyl-2-[6-[rac-(3aS,6aS)-2,3,3a,5,6,6a-hexahydro-1H-pyrrolo[3,2- b]pyrrol-4-yl]pyridazin-3-yl]-5-(trifluoromethyl)phenol;hydrochloride;(348) 1-[(4aR,7aS)-4-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]-2,3,4a,5,7,7a-hexahydropyrrolo[3,4-b][1,4]oxazin- 6-yl]ethanone; (349) 1-[(4aS,8aS)-4-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-6-yl]ethanone; (350) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-chloro-phenol; (351) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-(difluoromethyl)pyridazin-3-yl]-6-fluoro-phenol; (352) 1-[(4aS,7aR)-4-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]-2,3,4a,5,7,7a-hexahydropyrrolo[3,4-b][1,4]oxazin- 6-yl]ethanone; (353) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-6-fluoro-3-methyl-phenol; (354) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-methyl-phenol; (355) 2-[6-[(4aS,8aR)-6-(2,2,2-trifluoroethyl)-3,4a,5,7,8,8a-hexahydro-2H- pyrido[4,3-b][1,4]oxazin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (356) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-methyl-pyridazin-3-yl]-6-fluoro-phenol; (357) 1-[(4aS,8aR)-4-[6-(4-chloro-2-hydroxy-phenyl)-5-methyl-pyridazin-3-yl]- 3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-6-yl]ethanone; (358) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-ethyl-phenol; (359) 2-[6-[(2S,6R)-2-(hydroxymethyl)-6-methyl-morpholin-4-yl]pyridazin-3-yl]- 3,5-dimethyl-phenol; (360) 2-[6-(5,6-dihydro-2H-pyrazolo[4,3-b][1,4]oxazin-7-yl)pyridazin-3-yl]-3- methyl-5-(trifluoromethyl)phenol; (361) 3-methyl-2-[6-[rac-(4aR,7aS)-6-ethyl-2,3,4a,5,7,7a-hexahydropyrrolo[3,4- b][1,4]oxazin-4-yl]pyridazin-3-yl]-5-(trifluoromethyl)phenol;(362) 2-[6-(2,3-dihydropyrido[4,3-b][1,4]oxazin-4-yl)pyridazin-3-yl]-3,5- dimethyl-phenol; (363) 1-[(4aS,8aR)-4-[6-[2-hydroxy-4-(trifluoromethyl)phenyl]-5-methyl- pyridazin-3-yl]-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-6-yl]ethanone; (364) 2-[6-[rac-(3aS,7aS)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (365) 2-[6-[(2R,6R)-2-(hydroxymethyl)-6-methyl-morpholin-4-yl]pyridazin-3-yl]- 3,5-dimethyl-phenol; (366) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]-4-methyl-pyridazin-3-yl]-5-(trifluoromethyl)phenol; (367) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]-4-methyl-pyridazin-3-yl]-5-(trifluoromethyl)phenol; (368) 2-(hydroxymethyl)-4-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]morpholin-3-one; (369) 1-[(3aR,7aR)-1-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-6-yl]ethanone; (370) 1-[(3aS,7aS)-1-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-6-yl]ethanone; (371) 2-[6-[rac-(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (372) (4S)-1-[5-(difluoromethyl)-6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]-4-hydroxy-pyrrolidin-2-one; (373) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-methyl-pyridazin-3-yl]-5-methyl-phenol; (374) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]-4-methyl-pyridazin-3-yl]-5-methyl-phenol; (375) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]-4-methyl-pyridazin-3-yl]-5-methyl-phenol; (376) 3-methyl-2-[6-[rac-(4aR,7aR)-6-ethyl-2,3,4a,5,7,7a-hexahydropyrrolo[3,4- b][1,4]oxazin-4-yl]pyridazin-3-yl]-5-(trifluoromethyl)phenol;(377) 1-[rac-(3aS,6aS)-1-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]-2,3,3a,5,6,6a-hexahydropyrrolo[3,2-b]pyrrol-4- yl]ethanone; (378) 2-[6-[rac-(3aS,7aR)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (379) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-methyl-pyridazin-3-yl]-5-chloro-phenol; (380) 1-[(4aS,8aR)-4-[6-[2-ethyl-6-hydroxy-4-(trifluoromethyl)phenyl]pyridazin- 3-yl]-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-6-yl]ethanone; (381) 1-[(4aS,8aR)-4-[6-(4-chloro-2-ethyl-6-hydroxy-phenyl)pyridazin-3-yl]- 3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-6-yl]ethanone; (382) 2-[6-[(4aS,8aR)-2,3,4a,5,6,7,8,8a-octahydropyrido[4,3-b][1,4]oxazin-4-yl]- 4-(difluoromethyl)pyridazin-3-yl]-5-(trifluoromethyl)phenol; (383) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (384) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (385) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-methyl-phenol; (386) 1-[(4aS,8aR)-4-[5-(difluoromethyl)-6-[2-hydroxy-4- (trifluoromethyl)phenyl]pyridazin-3-yl]-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-6-yl]ethanone; (387) 1-[(4aS,8aR)-4-[5-(difluoromethyl)-6-(2-hydroxy-4-methyl- phenyl)pyridazin-3-yl]-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-6- yl]ethanone; (388) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-ethyl-phenol; (389) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-(trifluoromethyl)phenol; (390) 2-[6-[(2S,6S)-2-(hydroxymethyl)-6-methyl-morpholin-4-yl]pyridazin-3-yl]- 3,5-dimethyl-phenol;(391) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (392) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (393) 2-[6-[(3aR,7aS)-2,3,3a,4,5,6,7,7a-octahydropyrrolo[2,3-c]pyridin-1- yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (394) 1-[(3aR,7aR)-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]- 3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin-6-yl]ethanone; (395) 1-[(3aR,7aR)-1-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-6-yl]ethanone; (397) 1-[(4aS,8aR)-4-[6-(4-chloro-2-hydroxy-6-methyl-phenyl)pyridazin-3-yl]- 3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-6-yl]ethanone; (398) 1-[(4aR,8aS)-4-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-6-yl]ethanone; (399) 3,5-dichloro-2-[6-(1,1-dioxo-1,4-thiazinan-4-yl)pyridazin-3-yl]phenol; (400) 3,5-dichloro-2-[6-(1-oxo-1,4-thiazinan-4-yl)pyridazin-3-yl]phenol; (402) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-(trifluoromethyl)phenol; (403) 3,5-dimethyl-2-[6-[rac-(4aS,8aR)-3,4a,5,7,8,8a-hexahydro-2H-pyrano[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]phenol; (404) 2-[6-[(4aS,8aR)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (405) 1-[(4aS,8aR)-4-[4-(difluoromethyl)-6-(2-hydroxy-4,6-dimethyl- phenyl)pyridazin-3-yl]-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-6- yl]ethanone; (406) 2-[6-[(3aS,7aR)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin- 1-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (407) 2-[6-[(3aS,7aR)-2,3,3a,4,5,6,7,7a-octahydropyrrolo[2,3-c]pyridin-1- yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol;(408) 2-[6-[(4aS,8aR)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-ethyl-phenol; (409) 1-[(4aS,8aR)-4-[6-(2-hydroxy-6-methyl-phenyl)pyridazin-3-yl]- 3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-6-yl]ethanone; (410) 3,5-dimethyl-2-[6-(3-methyl-3,6-diazabicyclo[3.2.2]nonan-6-yl)pyridazin-3- yl]phenol; (411) 2-[6-[(4aS,8aR)-2,3,4a,5,6,7,8,8a-octahydropyrido[4,3-b][1,4]oxazin-4- yl]pyridazin-3-yl]-3-methyl-phenol; (412) 2-[6-[(4aS,8aR)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-methyl-phenol; (413) 1-[(3aR,7aR)-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]- 3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin-6-yl]ethanone; (414) 1-[(3aS,7aS)-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]- 3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin-6-yl]ethanone; (415) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-methyl-phenol; (416) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-methyl-phenol; (417) 3-methyl-2-[6-(3-methyl-3,6-diazabicyclo[3.2.2]nonan-6-yl)pyridazin-3-yl]- 5-(trifluoromethyl)phenol; (418) 3-ethyl-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-5- (trifluoromethyl)phenol; (419) (2S)-2-(hydroxymethyl)-4-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]morpholin-3-one; (420) (2R)-2-(hydroxymethyl)-4-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]morpholin-3-one; (421) 3,5-dimethyl-2-[6-[rac-(4aS,8aS)-3,4a,5,7,8,8a-hexahydro-2H-pyrano[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]phenol; (422) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-ethyl-phenol; (423) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-ethyl-phenol;(424) 1-[(4aS,8aR)-4-[6-(2-ethyl-6-hydroxy-phenyl)pyridazin-3-yl]-3,4a,5,7,8,8a- hexahydro-2H-pyrido[4,3-b][1,4]oxazin-6-yl]ethanone; (425) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-5-(difluoromethyl)pyridazin-3-yl]-3-ethyl-phenol; (426) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-(trifluoromethyl)phenol; (427) 2-[6-[rac-(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-(trifluoromethyl)phenol; (428) 3,5-dimethyl-2-[6-(9-methyl-1,9-diazaspiro[4.5]decan-1-yl)pyridazin-3- yl]phenol; (429) 2-[6-[(3aR,7aS)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin- 1-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (430) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-methyl-pyridazin-3-yl]-5-(trifluoromethyl)phenol; (431) 1-[(4aS,8aR)-4-[6-(2-hydroxy-4-methyl-phenyl)-5-methyl-pyridazin-3-yl]- 3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-6-yl]ethanone; (432) 2-[6-[(4aS,8aR)-6-isopropyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-ethyl-phenol; (433) 2-[6-[(4aS,8aR)-6-isopropyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (434) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-5-methyl-pyridazin-3-yl]-3,5-dimethyl-phenol; (435) 2-[6-[(4aS,8aR)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-methyl-pyridazin-3-yl]-5-methyl-phenol; (436) 2-[6-[(4aS,8aR)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-methyl-pyridazin-3-yl]-5-(trifluoromethyl)phenol; (437) 2-[6-[(4aS,8aR)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-methyl-pyridazin-3-yl]-5-chloro-phenol; (438) 3-methyl-2-[6-[rac-(4aS,8aR)-3,4a,5,7,8,8a-hexahydro-2H-pyrano[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-5-(trifluoromethyl)phenol; (439) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-5-methyl-pyridazin-3-yl]-3-ethyl-phenol;(440) 3,5-dimethyl-2-[6-(9-methyl-6-oxa-2,9-diazaspiro[4.5]decan-2-yl)pyridazin- 3-yl]phenol; (441) 3,5-dimethyl-2-[6-(1-methyl-4-oxa-1,8-diazaspiro[5.5]undecan-8- yl)pyridazin-3-yl]phenol; (442) 1-[(4aS,8aR)-4-[6-(4-chloro-2-hydroxy-phenyl)-5- (difluoromethyl)pyridazin-3-yl]-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazin-6- yl]ethanone; (443) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-ethyl-pyridazin-3-yl]-5-(trifluoromethyl)phenol; (444) 3,5-dimethyl-2-[6-(6-methyl-9-oxa-2,6-diazaspiro[4.5]decan-2-yl)pyridazin- 3-yl]phenol; (445) 3,5-dimethyl-2-[6-[(5S)-9-methyl-6-oxa-2,9-diazaspiro[4.5]decan-2- yl]pyridazin-3-yl]phenol; (446) 3,5-dimethyl-2-[6-[(5R)-9-methyl-6-oxa-2,9-diazaspiro[4.5]decan-2- yl]pyridazin-3-yl]phenol; (448) 3-methyl-2-[6-[rac-(4aS,8aS)-3,4a,5,7,8,8a-hexahydro-2H-pyrano[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-5-(trifluoromethyl)phenol; (449) 3,5-dimethyl-2-[6-(8-methyl-4-oxa-1,8-diazaspiro[5.5]undecan-1- yl)pyridazin-3-yl]phenol; (450) 3,5-dimethyl-2-[6-[(5R)-6-methyl-9-oxa-2,6-diazaspiro[4.5]decan-2- yl]pyridazin-3-yl]phenol; (451) 3,5-dimethyl-2-[6-[(5S)-6-methyl-9-oxa-2,6-diazaspiro[4.5]decan-2- yl]pyridazin-3-yl]phenol; (452) 2-[6-[rac-(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-ethyl-5-(trifluoromethyl)phenol; (455) 3,5-dimethyl-2-[6-(2-methyl-8-oxa-2,5-diazaspiro[3.5]nonan-5- yl)pyridazin-3-yl]phenol; (456) 2-[6-[(4aS,8aR)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-chloro-phenol; (457) 1-[(3aR,7aR)-1-[6-(2-hydroxy-4-methyl-phenyl)-5-methyl-pyridazin-3-yl]- 3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin-6-yl]ethanone;(458) 2-[6-[rac-(3aS,7aR)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-(trifluoromethyl)phenol; (459) 2-[6-[rac-(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-ethyl-5-methyl-phenol; (460) 2-[6-[rac-(3aS,7aR)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]-4-methyl-pyridazin-3-yl]-5-methyl-phenol; (461) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-5-chloro-3-ethyl-phenol; (462) 1-[(4aR,8aR)-5-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]-2,3,4,4a,6,7,8,8a-octahydro-1,5-naphthyridin-1- yl]ethanone; (463) 1-[(4aS,8aS)-5-[6-[2-hydroxy-6-methyl-4- (trifluoromethyl)phenyl]pyridazin-3-yl]-2,3,4,4a,6,7,8,8a-octahydro-1,5-naphthyridin-1- yl]ethanone; (466) (4aS,6S,7aR)-4-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]- 3,4a,5,6,7,7a-hexahydro-2H-cyclopenta[b][1,4]oxazin-6-ol; (467) (4aR,6R,7aS)-4-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]- 3,4a,5,6,7,7a-hexahydro-2H-cyclopenta[b][1,4]oxazin-6-ol; (468) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]-4-methyl-pyridazin-3-yl]-5-chloro-phenol; (469) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]-4-methyl-pyridazin-3-yl]-5-chloro-phenol; (470) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-ethyl-pyridazin-3-yl]-5-methyl-phenol; (471) 5-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-methyl-pyridazin-3-yl]indan-4-ol; (472) 2-[6-[(4aS,8aR)-6-isopropyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-methyl-pyridazin-3-yl]-5-methyl-phenol; (473) 2-[6-[(3aS,7aR)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin- 1-yl]pyridazin-3-yl]-3-(trifluoromethyl)phenol; (474) 2-[6-[(3aR,7aS)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin- 1-yl]-4-methyl-pyridazin-3-yl]-5-methyl-phenol;(475) 2-[6-[(3aS,7aR)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin- 1-yl]-4-methyl-pyridazin-3-yl]-5-methyl-phenol; (476) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-ethyl-5-methyl-phenol; (477) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-ethyl-5-methyl-phenol; (479) 2-[6-[(4aS,8aR)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-methyl-pyridazin-3-yl]-5-fluoro-phenol; (480) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]-4-methyl-pyridazin-3-yl]-5-fluoro-phenol; (481) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-ethyl-5-(trifluoromethyl)phenol; (482) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-(trifluoromethyl)phenol; (483) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-(trifluoromethyl)phenol; (484) 3-methyl-2-[6-[rac-(3aS,6aS)-1-methyl-2,3,3a,5,6,6a-hexahydropyrrolo[3,2- b]pyrrol-4-yl]pyridazin-3-yl]-5-(trifluoromethyl)phenol; (485) 2-[6-[(3aR,7aS)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin- 1-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-(trifluoromethyl)phenol; (486) 2-[6-[(3aS,7aR)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin- 1-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-(trifluoromethyl)phenol; (487) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]-5-(difluoromethyl)pyridazin-3-yl]-3,5-dimethyl-phenol; (488) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]-5-(difluoromethyl)pyridazin-3-yl]-3,5-dimethyl-phenol; (489) 2-[6-[(3aR,7aS)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin- 1-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-methyl-phenol; (490) 2-[6-[(3aS,7aR)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin- 1-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-methyl-phenol; (491) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-ethyl-5-(trifluoromethyl)phenol;(492) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-3-ethyl-5-(trifluoromethyl)phenol; (493) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-5-chloro-3-ethyl-phenol (494) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-5-chloro-3-ethyl-phenol; (496) 2-[6-[(3aR,7aS)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin- 1-yl]pyridazin-3-yl]-5-chloro-3-methyl-phenol; (497) 2-[6-[(3aS,7aR)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin- 1-yl]pyridazin-3-yl]-5-chloro-3-methyl-phenol; (498) 2-[6-[(3aS,7aR)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin- 1-yl]pyridazin-3-yl]-3-methyl-phenol; (499) 2-[6-[(3aR,7aS)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin- 1-yl]pyridazin-3-yl]-3-methyl-phenol; (500) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-chloro-phenol; (501) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-chloro-phenol; (502) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-5-chloro-3-methyl-phenol; (503) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]pyridazin-3-yl]-5-chloro-3-methyl-phenol; (504) 2-[6-[(3aS,7aR)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin- 1-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (505) 2-[6-[(3aR,7aS)-6-ethyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin- 1-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (506) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-methyl-phenol; (507) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-1-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-methyl-phenol; (508) 5-ethynyl-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3- methyl-phenol;(509) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-5-methyl-3- (trifluoromethyl)phenol; (510) 1-[(3aS,7aS)-1-[5-(difluoromethyl)-6-[2-hydroxy-4- (trifluoromethyl)phenyl]pyridazin-3-yl]-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-6-yl]ethanone; (511) 1-[(3aR,7aR)-1-[5-(difluoromethyl)-6-[2-hydroxy-4- (trifluoromethyl)phenyl]pyridazin-3-yl]-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3- c]pyridin-6-yl]ethanone; (512) 1-[(3aS,7aS)-1-[4-(difluoromethyl)-6-(2-hydroxy-4,6-dimethyl- phenyl)pyridazin-3-yl]-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin-6-yl]ethanone; (513) 1-[(3aR,7aR)-1-[4-(difluoromethyl)-6-(2-hydroxy-4,6-dimethyl- phenyl)pyridazin-3-yl]-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin-6-yl]ethanone; (514) 1-[(3aR,7aR)-1-[6-[2-hydroxy-4-(trifluoromethyl)phenyl]-5-methyl- pyridazin-3-yl]-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin-6-yl]ethanone; (515) 2-[6-[(4aS,8aS)-5-methyl-2,3,4,4a,6,7,8,8a-octahydro-1,5-naphthyridin-1- yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (516) 2-[6-[(4aR,8aR)-5-methyl-2,3,4,4a,6,7,8,8a-octahydro-1,5-naphthyridin-1- yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (517) 2-[6-[(4aR,8aS)-7-methyl-2,3,4,4a,5,6,8,8a-octahydro-1,7-naphthyridin-1- yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (518) 2-[6-[(4aS,8aS)-7-methyl-2,3,4,4a,5,6,8,8a-octahydro-1,7-naphthyridin-1- yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (519) 2-[6-[(4aR,8aR)-7-methyl-2,3,4,4a,5,6,8,8a-octahydro-1,7-naphthyridin-1- yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (520) 2-[6-[(4aS,8aR)-7-methyl-2,3,4,4a,5,6,8,8a-octahydro-1,7-naphthyridin-1- yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (521) 2-[6-[(4aS,8aR)-6-(2-fluoroethyl)-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (522) 2-[6-[(4aS,8aR)-6-(2-fluoroethyl)-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-5-chloro-3-methyl-phenol; (523) 2-[6-[(4aR,8aR)-7-methyl-2,3,4,4a,5,6,8,8a-octahydro-1,7-naphthyridin-1- yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol;(524) 2-[6-[(4aS,8aS)-7-methyl-2,3,4,4a,5,6,8,8a-octahydro-1,7-naphthyridin-1- yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (525) 2-[6-[(4aS,8aR)-6-(2-fluoroethyl)-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-5-chloro-phenol; (526) 2-[6-[(4aS,8aR)-6-ethyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-5-chloro-3-ethyl-phenol; (527) 2-[6-[(4aS,8aR)-6-(3-fluoropropyl)-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3- b][1,4]oxazin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; and (528) 5-methyl-2-[4-methyl-6-[rac-(3aS,7aR)-6-isopropyl-3,3a,4,5,7,7a- hexahydro-2H-pyrrolo[2,3-c]pyridin-1-yl]pyridazin-3-yl]phenol.

10. Medicament, characterized in that it comprises a compound of formula (I) according to any one of claims 1 to 9, or pharmaceutically acceptable salt thereof.

11. Pharmaceutical composition, characterized in that it comprises a compound of formula (I) according to any one of claims 1 to 9, or pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient.

12. A compound of formula (I) according to any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof for use as a medicine.

13. A compound of formula (I) according to any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof for use as inhibitor of NOD-like receptor protein 3 (NLRP3) inflammasome.

14. A compound of formula (I) according to any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof for use in the prevention and / or in the treatment of Parkinson’s disease, frontotemporal Dementia, Multiple System Atrophy, Alzheimer’s disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis or brain injury.