Bicyclic ureas as kinase inhibitors

HK40138091APending Publication Date: 2026-09-25INCYTE CORP
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Patent Information

Application Number
HK62026125749
Authority / Receiving Office
HK · HK
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-11-13
Filing Date
2026-07-06
Publication Date
2026-09-25
Estimated Expiration
2044-03-11
Patent Text Reader

Abstract

The present application provides bicyclic urea compounds that modulate the activity of JAK2, which are useful in the treatment of various diseases, including cancer.
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Description

Abstract This application provides bicyclic urea compounds that modulate JAK2 activity, which can be used to treat various diseases, including cancer.

Claims

WHAT IS CLAIMED IS:

1. A compound of Formula I:I or a pharmaceutically acceptable salt thereof, wherein: R1is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein the C1-6alkyl, C2-6alkenyl, and C2-6alkynyl of R1are each optionally substituted with 1, 2, or 3 independently selected R1Asubstituents; each R1Ais independently selected from halo, oxo, CN, NO2, ORa11, SRa11, NHORa11, C(O)Rb11, C(O)NRc11Rd11, C(O)NRc11(ORa11), C(O)ORa11, OC(O)Rb11, OC(O)NRc11Rd11, NRc11Rd11, NRc11NRc11Rd11,NRc11C(O)Rb11, NRc11C(O)ORa11, NRc11C(O)NRc11Rd11, C(=NRe11)Rb11, C(=NRe11)NRc11Rd11, NRc11C(=NRe11)NRc11Rd11, NRc11C(=NRe11)Rb11, NRc11S(O)Rb11, NRc11S(O)NRc11Rd11, NRc11S(O)2Rb11, NRc11S(O)(=NRe11)Rb11, NRc11S(O)2NRc11Rd11, S(O)Rb11, S(O)NRc11Rd11, S(O)2Rb11, S(O)2NRc11Rd11, OS(O)(=NRe11)Rb11, and OS(O)2Rb11; each Ra11, Rb11, Rc11, and Rd11is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, and C2-6alkynyl, wherein the C1-6alkyl, C2-6alkenyl, and C2-6alkynyl of Ra11, Rb11, Rc11and Rd11are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected RMsubstituents; each Re11is independently selected from H, OH, CN, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, C2-6alkenyl, and C2-6alkynyl; Cy2is selected from C3-10cycloalkyl and 4-12 membered heterocycloalkyl, wherein the C3-10cycloalkyl and 4-12 membered heterocycloalkyl are each substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R2substituents; each R2is independently selected from halo, oxo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, (4-10 membered heterocycloalkyl)-C1-6alkyl-, CN, NO2, ORa2, SRa2, NHORa2, C(O)Rb2, C(O)NRc2Rd2, C(O)NRc2(ORa2), C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)ORa2, NRc2C(O)NRc2Rd2, C(=NRe2)Rb2,C(=NRe2)NRc2Rd2, NRc2C(=NRe2)NRc2Rd2, NRc2C(=NRe2)Rb2, NRc2S(O)Rb2, NRc2S(O)NRc2Rd2, NRc2S(O)2Rb2, NRc2S(O)(=NRe2)Rb2, NRc2S(O)2NRc2Rd2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, S(O)2NRc2Rd2, OS(O)(=NRe2)Rb2, OS(O)2Rb2, SF5, P(O)Rf2Rg2, OP(O)(ORh2)(ORi2), P(O)(ORh2)(ORi2), and BRj2Rk2, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of R2are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R2Asubstituents; each Ra2, Rc2, and Rd2is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of Ra2, Rc2and Rd2are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R2Asubstituents; or, any Rc2and Rd2attached to the same N atom, together with the N atom to which they are attached, form a 5-10 membered heteroaryl or a 4-10 membered heterocycloalkyl group, wherein the 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents; each Rb2is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of Rb2are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R2Asubstituents; each Re2is independently selected from H, OH, CN, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl- C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-;each Rf2and Rg2is independently selected from H, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl- C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-; each Rh2and Ri2is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-; each Rj2and Rk2is independently selected from OH, C1-6alkoxy, and C1-6haloalkoxy; or any Rj2and Rk2attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6alkyl and C1-6haloalkyl; each R2Ais independently selected from halo, oxo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, (4-10 membered heterocycloalkyl)-C1-6alkyl-, CN, NO2, ORa21, SRa21, NHORa21, C(O)Rb21, C(O)NRc21Rd21, C(O)NRc21(ORa21), C(O)ORa21, OC(O)Rb21, OC(O)NRc21Rd21, NRc21Rd21, NRc21NRc21Rd21, NRc21C(O)Rb21, NRc21C(O)ORa21, NRc21C(O)NRc21Rd21, C(=NRe21)Rb21, C(=NRe21)NRc21Rd21, NRc21C(=NRe21)NRc21Rd21, NRc21C(=NRe21)Rb21, NRc21S(O)Rb21, NRc21S(O)NRc21Rd21, NRc21S(O)2Rb21, NRc21S(O)(=NRe21)Rb21, NRc21S(O)2NRc21Rd21, S(O)Rb21, S(O)NRc21Rd21, S(O)2Rb21, S(O)2NRc21Rd21, OS(O)(=NRe21)Rb21, OS(O)2Rb21, SF5, P(O)Rf21Rg21, OP(O)(ORh21)(ORi21), P(O)(ORh21)(ORi21), and BRj21Rk21, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl- C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of R2Aare each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R2Bsubstituents; each Ra21, Rc21, and Rd21is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of Ra21, Rc21and Rd21are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R2Bsubstituents; or, any Rc21and Rd21attached to the same N atom, together with the N atom to which they are attached, form a 5-10 membered heteroaryl or a 4-10 membered heterocycloalkyl group, wherein the 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R2Bsubstituents; each Rb21is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of Rb21are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R2Bsubstituents; each Re21is independently selected from H, OH, CN, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl- C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6 alkyl-; each Rf21and Rg21is independently selected from H, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl- C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6 alkyl-; each Rh21and Ri21is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-; each Rj21and Rk21is independently selected from OH, C1-6alkoxy, and C1-6haloalkoxy; or any Rj21and Rk21attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6alkyl and C1-6haloalkyl; each R2Bis independently selected from halo, oxo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 memberedheterocycloalkyl, phenyl-C1-6alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6alkyl-, (4-7 membered heterocycloalkyl)-C1-6alkyl-, CN, NO2, ORa22, SRa22, NHORa22, C(O)Rb22, C(O)NRc22Rd22, C(O)NRc22(ORa22), C(O)ORa22, OC(O)Rb22, OC(O)NRc22Rd22, NRc22Rd22, NRc22NRc22Rd22,NRc22C(O)Rb22, NRc22C(O)ORa22, NRc22C(O)NRc22Rd22, C(=NRe22)Rb22, C(=NRe22)NRc22Rd22, NRc22C(=NRe22)NRc22Rd22, NRc22C(=NRe22)Rb22, NRc22S(O)Rb22, NRc22S(O)NRc22Rd22, NRc22S(O)2Rb22, NRc22S(O)(=NRe22)Rb22, NRc22S(O)2NRc22Rd22, S(O)Rb22, S(O)NRc22Rd22, S(O)2Rb22, S(O)2NRc22Rd22, OS(O)(=NRe22)Rb22, and OS(O)2Rb22, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6 alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6alkyl-, (4-7 membered heterocycloalkyl)-C1-6alkyl- of R2Care each optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents; each Ra22, Rc22, and Rd22is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6 alkyl-, and (4-7 membered heterocycloalkyl)-C1-6alkyl-, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6 alkyl-, and (4-7 membered heterocycloalkyl)-C1-6alkyl- of Ra22, Rc22and Rd22are each optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents; or, any Rc22and Rd22attached to the same N atom, together with the N atom to which they are attached, form a 5-6 membered heteroaryl or a 4-7 membered heterocycloalkyl group, wherein the 5-6 membered heteroaryl or 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents; each Rb22is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6 alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6alkyl-, and (4-7 membered heterocycloalkyl)-C1-6alkyl-, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6 alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6alkyl-, and (4-7 membered heterocycloalkyl)-C1-6alkyl- of Rb22are each optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents; each Re22is independently selected from H, OH, CN, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 memberedheteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6alkyl-, and (4-7 membered heterocycloalkyl)-C1-6alkyl-; R3is selected from H, halo, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; Cy4is selected from C6-10aryl and 5-14 membered heteroaryl, wherein the C6-10aryl and 5-12 membered heteroaryl are each optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R4substituents; each R4is independently selected from halo, oxo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, (4-10 membered heterocycloalkyl)-C1-6alkyl-, CN, NO2, ORa4, SRa4, NHORa4, C(O)Rb4, C(O)NRc4Rd4, C(O)NRc4(ORa4), C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, NRc4C(O)NRc4Rd4, C(=NRe4)Rb4, C(=NRe4)NRc4Rd4, NRc4C(=NRe4)NRc4Rd4, NRc4C(=NRe4)Rb4, NRc4S(O)Rb4, NRc4S(O)NRc4Rd4, NRc4S(O)2Rb4, NRc4S(O)(=NRe4)Rb4, NRc4S(O)2NRc4Rd4, S(O)Rb4, S(O)NRc4Rd4, S(O)2Rb4, S(O)2NRc4Rd4, OS(O)(=NRe4)Rb4, OS(O)2Rb4, SF5, P(O)Rf4Rg4, OP(O)(ORh4)(ORi4), P(O)(ORh4)(ORi4), and BRj4Rk4, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of R4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R4Asubstituents; each Ra4, Rc4, and Rd4is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of Ra4, Rc4and Rd4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R4Asubstituents; or, any Rc4and Rd4attached to the same N atom, together with the N atom to which they are attached, form a 5-10 membered heteroaryl or a 4-10 membered heterocycloalkyl group, wherein the 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R4Asubstituents; each Rb4is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 memberedheterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of Rb4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R4Asubstituents; each Re4is independently selected from H, OH, CN, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl- C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6 alkyl-; each Rf4and Rg4is independently selected from H, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl- C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6 alkyl-; each Rh4and Ri4is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-; each Rj4and Rk4is independently selected from OH, C1-6alkoxy, and C1-6haloalkoxy; or any Rj4and Rk4attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6alkyl and C1-6haloalkyl; each R4Ais independently selected from halo, oxo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, (4-10 membered heterocycloalkyl)-C1-6alkyl-, CN, NO2, ORa41, SRa41, NHORa41, C(O)Rb41, C(O)NRc41Rd41, C(O)NRc41(ORa41), C(O)ORa41, OC(O)Rb41, OC(O)NRc41Rd41, NRc41Rd41, NRc41NRc41Rd41, NRc41C(O)Rb41, NRc41C(O)ORa41, NRc41C(O)NRc41Rd41, C(=NRe41)Rb41, C(=NRe41)NRc41Rd41, NRc41C(=NRe41)NRc41Rd41, NRc41C(=NRe41)Rb41, NRc41S(O)Rb41, NRc41S(O)NRc41Rd41, NRc41S(O)2Rb41, NRc41S(O)(=NRe41)Rb41, NRc41S(O)2NRc41Rd41, S(O)Rb41, S(O)NRc41Rd41, S(O)2Rb41, S(O)2NRc41Rd41, OS(O)(=NRe41)Rb41, OS(O)2Rb41, SF5, P(O)Rf41Rg41, OP(O)(ORh41)(ORi41), P(O)(ORh41)(ORi41), and BRj41Rk41, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl- C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of R41are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R4Bsubstituents; each Ra41, Rc41, and Rd41is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of Ra41, Rc41and Rd41are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R4Bsubstituents; or, any Rc41and Rd41attached to the same N atom, together with the N atom to which they are attached, form a 5-10 membered heteroaryl or a 4-10 membered heterocycloalkyl group, wherein the 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R4Bsubstituents; each Rb41is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6 alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of Rb41are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R4Bsubstituents; each Re41is independently selected from H, OH, CN, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl- C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6 alkyl-; each Rf41and Rg41is independently selected from H, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl- C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-;each Rh41and Ri41is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-; each Rj41and Rk41is independently selected from OH, C1-6alkoxy, and C1-6haloalkoxy; or any Rj41and Rk41attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6alkyl and C1-6haloalkyl; each R4Bis independently selected from halo, oxo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6 alkyl-, (4-7 membered heterocycloalkyl)-C1-6alkyl-, CN, NO2, ORa42, SRa42, NHORa42, C(O)Rb42, C(O)NRc42Rd42, C(O)NRc42(ORa42), C(O)ORa42, OC(O)Rb42, OC(O)NRc42Rd42, NRc42Rd42, NRc42NRc42Rd42, NRc42C(O)Rb42, NRc42C(O)ORa42, NRc42C(O)NRc42Rd42, C(=NRe42)Rb42, C(=NRe42)NRc42Rd42, NRc42C(=NRe42)NRc42Rd42, NRc42C(=NRe42)Rb42, NRc42S(O)Rb42, NRc42S(O)NRc42Rd42, NRc42S(O)2Rb42, NRc42S(O)(=NRe42)Rb42, NRc42S(O)2NRc42Rd42, S(O)Rb42, S(O)NRc42Rd42, S(O)2Rb42, S(O)2NRc42Rd42, OS(O)(=NRe42)Rb42, and OS(O)2Rb42, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6 alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6alkyl-, and (4-7 membered heterocycloalkyl)-C1-6alkyl- of R4Care each optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents; each Ra42, Rc42, and Rd42is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6 alkyl-, and (4-7 membered heterocycloalkyl)-C1-6alkyl-, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6 alkyl-, and (4-7 membered heterocycloalkyl)-C1-6alkyl- of Ra42, Rc42and Rd42are each optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents; or, any Rc42and Rd42attached to the same N atom, together with the N atom to which they are attached, form a 5-6 membered heteroaryl or a 4-7 membered heterocycloalkyl group, wherein the 5-6 membered heteroaryl or 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents;each Rb42is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6alkyl-, and (4-7 membered heterocycloalkyl)-C1-6alkyl-, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6alkyl-, and (4-7 membered heterocycloalkyl)-C1-6alkyl- of Rb42are each optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents; each Re42is independently selected from H, OH, CN, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6alkyl-, and (4-7 membered heterocycloalkyl)-C1-6alkyl-; R5is selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-12cycloalkyl, C6-10aryl, 5- 12 membered heteroaryl, 4-12 membered heterocycloalkyl, ORw2, SRw2, NRw2Rw3, C(O)Rw2, C(O)NRw2Rw3, C(O)ORw2, OC(O)Rw2, OC(NRw3)Rw2, OC(O)NRw2Rw3, NRw3C(O)Rw2, NRw3C(O)ORw2, NRw3C(O)NRw2Rw3, NRw3S(O)Rw2, NRw3S(O)NRw2Rw3, NRw3S(O)2Rw2, S(O)Rw2, S(O)NRw2Rw3, S(O)2Rw2, and S(O)2NRw2Rw3; wherein the C1-6alkyl and C6-10aryl of R5are each substituted with 1 Rw1substituent and optionally substituted 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R5Asubstituents; or the C6-10aryl of R5is substituted with 1 Rw5substituent and optionally substituted 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R5Asubstituents; and the C2-6alkenyl, C2-6alkynyl, C3-12cycloalkyl, 5-12 membered heteroaryl, and 4-12 membered heterocycloalkyl, of R5are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R5Asubstituents; Rw1is selected from C2-6alkenyl, C2-6alkynyl, C3-12cycloalkyl, 5-12 membered heteroaryl, C6-12 aryl, 4-12 membered heterocycloalkyl, ORw4, NHRw4, NRw3Rw4, SRw4, S(O)2Rw4, C(O)Rw4, C(O)NHRw4, C(O)NRw3Rw4, OC(O)Rw4, S(O)Rw3, S(O)NRw3Rw3, S(O)2Rw2, and S(O)2NRw3Rw3, wherein the C2-6alkenyl, C2-6alkynyl, C3-12cycloalkyl, 5-12 membered heteroaryl, C6-12 aryl, and 4-12 membered heterocycloalkyl of Rw1are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R5Asubstituents; each Rw2is independently selected from C3-12cycloalkyl, 5-12 membered heteroaryl, and 4-12 membered heterocycloalkyl, wherein the C3-12cycloalkyl, 5-12 membered heteroaryl, and 4-12 membered heterocycloalkyl of Rw2are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R5Asubstituents;each Rw3is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of Rw3are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R5Asubstituents; each Rw4is independently selected from C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10 aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-, wherein the C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of Ra51, Rc51and Rd51are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R5Bsubstituents; Rw5is C1-6alkyl which is substituted with oxo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, (4-10 membered heterocycloalkyl)-C1-6alkyl-, CN, NO2, ORa51, SRa51, NHORa51, C(O)Rb51, C(O)NRc51Rd51, C(O)NRc51(ORa51), C(O)ORa51, OC(O)Rb51, OC(O)NRc51Rd51, NRc51Rd51, NRc51NRc51Rd51, NRc51C(O)Rb51, NRc51C(O)ORa51, NRc51C(O)NRc51Rd51, C(=NRe51)Rb51, C(=NRe51)NRc51Rd51, NRc51C(=NRe51)NRc51Rd51, NRc51C(=NRe51)Rb51, NRc51S(O)Rb51, NRc51S(O)NRc51Rd51, NRc51S(O)2Rb51, NRc51S(O)(=NRe51)Rb51, NRc51S(O)2NRc51Rd51, S(O)Rb51, S(O)NRc51Rd51, S(O)2Rb51, S(O)2NRc51Rd51, OS(O)(=NRe51)Rb51, OS(O)2Rb51, SF5, P(O)Rf51Rg51, OP(O)(ORh51)(ORi51), P(O)(ORh51)(ORi51), or BRj51Rk51, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of Rw5are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R5Bsubstituents; each R5Ais independently selected from halo, oxo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, (4-10 membered heterocycloalkyl)-C1-6alkyl-, CN, NO2, ORa51, SRa51,NHORa51, C(O)Rb51, C(O)NRc51Rd51, C(O)NRc51(ORa51), C(O)ORa51, OC(O)Rb51, OC(O)NRc51Rd51, NRc51Rd51, NRc51NRc51Rd51,NRc51C(O)Rb51, NRc51C(O)ORa51, NRc51C(O)NRc51Rd51, C(=NRe51)Rb51, C(=NRe51)NRc51Rd51, NRc51C(=NRe51)NRc51Rd51, NRc51C(=NRe51)Rb51, NRc51S(O)Rb51, NRc51S(O)NRc51Rd51, NRc51S(O)2Rb51, NRc51S(O)(=NRe51)Rb51, NRc51S(O)2NRc51Rd51, S(O)Rb51, S(O)NRc51Rd51, S(O)2Rb51, S(O)2NRc51Rd51, OS(O)(=NRe51)Rb51, OS(O)2Rb51, SF5, P(O)Rf51Rg51, OP(O)(ORh51)(ORi51), P(O)(ORh51)(ORi51), and BRj51Rk51, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl- C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of R5Aare each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R5Bsubstituents; each Ra51, Rc51, and Rd51is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of Ra51, Rc51and Rd51are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R5Bsubstituents; or, any Rc51and Rd51attached to the same N atom, together with the N atom to which they are attached, form a 5-10 membered heteroaryl or a 4-10 membered heterocycloalkyl group, wherein the 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R5Bsubstituents; each Rb51is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6 alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of Rb51are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R5Bsubstituents; each Re51is independently selected from H, OH, CN, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-; each Rf51and Rg51is independently selected from H, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl- C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-; each Rh51and Ri51is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl-C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-; each Rj51and Rk51is independently selected from OH, C1-6alkoxy, and C1-6haloalkoxy; or any Rj51and Rk51attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-6alkyl and C1-6haloalkyl; each R5Bis independently selected from halo, oxo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6 alkyl-, (4-7 membered heterocycloalkyl)-C1-6alkyl-, CN, NO2, ORa52, SRa52, NHORa52, C(O)Rb52, C(O)NRc52Rd52, C(O)NRc52(ORa52), C(O)ORa52, OC(O)Rb52, OC(O)NRc52Rd52, NRc52Rd52, NRc52NRc52Rd52, NRc52C(O)Rb52, NRc52C(O)ORa52, NRc52C(O)NRc52Rd52, C(=NRe52)Rb52, C(=NRe52)NRc52Rd52, NRc52C(=NRe52)NRc52Rd52, NRc52C(=NRe52)Rb52, NRc52S(O)Rb52, NRc52S(O)NRc52Rd52, NRc52S(O)2Rb52, NRc52S(O)(=NRe52)Rb52, NRc52S(O)2NRc52Rd52, S(O)Rb52, S(O)NRc52Rd52, S(O)2Rb52, S(O)2NRc52Rd52, OS(O)(=NRe52)Rb52, and OS(O)2Rb52, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6 alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6alkyl-, and (4-7 membered heterocycloalkyl)-C1-6alkyl- of R5Bare each optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents; each Ra52, Rc52, and Rd52is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6alkyl-, and (4-7 membered heterocycloalkyl)-C1-6alkyl-, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 memberedheterocycloalkyl, phenyl-C1-6alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6alkyl-, and (4-7 membered heterocycloalkyl)-C1-6alkyl- of Ra52, Rc52and Rd52are each optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents; or, any Rc52and Rd52attached to the same N atom, together with the N atom to which they are attached, form a 5-6 membered heteroaryl or a 4-7 membered heterocycloalkyl group, wherein the 5-6 membered heteroaryl or 4-7 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents; each Rb52is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6 alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6alkyl-, and (4-7 membered heterocycloalkyl)-C1-6alkyl-, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6 alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6alkyl-, and (4-7 membered heterocycloalkyl)-C1-6alkyl- of Rb52are each optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents; each Re52is independently selected from H, OH, CN, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, C2-6alkenyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6alkyl-, C3-7cycloalkyl-C1-6alkyl-, (5-6 membered heteroaryl)-C1-6alkyl-, and (4-7 membered heterocycloalkyl)-C1-6alkyl-; and each RMis independently selected from H, OH, halo, oxo, CN, C(O)OH, NH2, NO2, SF5, C1-6alkyl, C1-6alkoxy, C1-6haloalkoxy, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10aryl- C1-6alkyl-, C3-10cycloalkyl-C1-6alkyl-, (5-10 membered heteroaryl)-C1-6alkyl-, and (4-10 membered heterocycloalkyl)-C1-6alkyl-; provided that: (i) Cy4is not triazolopyridinyl; and (ii) R5is not morpholinyl or piperazinyl; and (iii) when Cy4is phenyl, R5is not pyridinyl or pyrimidinyl.

2. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I is a compound of Formula II:II or a pharmaceutically acceptable salt thereof, wherein: R4is selected from C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, ORa4, and NRc4C(O)ORa4, wherein the C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl of R4are each optionally substituted with 1, 2, 3, or 4 independently selected R4Asubstituents; each Ra4, Rc4, and Rd4is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, and C2-6alkynyl; each R4Ais independently selected from C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, and CN; R5is selected from triazolyl, pyrazolyl, piperidinyl, tetrahydropyranyl, NRw2Rw3, NRw3C(O)Rw2, NRw3C(O)ORw2, and NRw3S(O)2Rw2, wherein the triazolyl, pyrazolyl, piperidinyl, and tetrahydropyranyl of R5are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents; each Rw2is independently selected from C3-12cycloalkyl, 5-12 membered heteroaryl, and 4-12 membered heterocycloalkyl, wherein the C3-12cycloalkyl, 5-12 membered heteroaryl, and 4-12 membered heterocycloalkyl of Rw2are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents; each Rw3is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, and C2-6alkynyl; each R5Ais independently selected from halo, oxo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, CN, NO2, ORa51, SRa51, NHORa51, C(O)Rb51, C(O)NRc51Rd51, C(O)NRc51(ORa51), C(O)ORa51, OC(O)Rb51, OC(O)NRc51Rd51, NRc51Rd51, NRc51NRc51Rd51,NRc51C(O)Rb51, NRc51C(O)ORa51, NRc51C(O)NRc51Rd51, NRc51S(O)Rb51, NRc51S(O)NRc51Rd51, NRc51S(O)2Rb51, NRc51S(O)2NRc51Rd51, S(O)Rb51, S(O)NRc51Rd51, S(O)2Rb51, and S(O)2NRc51Rd51; and each Ra51, Rb51, Rc51, and Rd51is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, and C2-6alkynyl.

3. The compound of claim 1 or 2, or a pharmaceutically acceptable salt thereof, wherein R4is selected from phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, ORa4, and NRc4C(O)ORa4, wherein the phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl of R4are each optionally substituted with 1, 2, 3, or 4 independently selected R4Asubstituents.

4. The compound of claim 1 or 2, or a pharmaceutically acceptable salt thereof, wherein R4is selected from phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, ORa4, and NRc4C(O)ORa4, wherein the phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl of R4are each optionally substituted with 1, 2, 3, or 4 independently selected R4Asubstituents.

5. The compound of claim 1 or 2, or a pharmaceutically acceptable salt thereof, wherein R4is selected from phenyl, tetrahydropyranyl, pyrazolyl, ORa4, and NRc4C(O)ORa4, wherein the phenyl, tetrahydropyranyl, and pyrazolyl of R4are each optionally substituted with 1, 2, 3, or 4 independently selected R4Asubstituents; and each Ra4and Rc4is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, and C2-6alkynyl.

6. The compound of any one of claims 1 to 5, or a pharmaceutically acceptable salt thereof, wherein each R4Ais independently selected from C1-6alkyl, C1-6haloalkyl, and CN.

7. The compound of any one of claims 1 to 5, or a pharmaceutically acceptable salt thereof, wherein each R4Ais independently selected from C1-6alkyl and CN.

8. The compound of any one of claims 1 to 5, or a pharmaceutically acceptable salt thereof, wherein each R4Ais independently selected from methyl and CN.

9. The compound of claim 1 or 2, or a pharmaceutically acceptable salt thereof, wherein R4is selected from phenyl, tetrahydropyranyl, pyrazolyl, ORa4, and NRc4C(O)ORa4, wherein the phenyl, tetrahydropyranyl, and pyrazolyl of R4are each optionally substituted with 1 or 2 independently selected R4Asubstituents; and each Ra4and Rc4is independently selected from H and C1-6alkyl; and each R4Ais independently selected from C1-6alkyl and CN.

10. The compound of any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof, wherein R5is selected from triazolyl, pyrazolyl, piperidinyl, tetrahydropyranyl, NHRw2, NHC(O)Rw2, NHC(O)ORw2, and NHS(O)2Rw2, wherein the triazolyl, pyrazolyl, piperidinyl, and tetrahydropyranyl of R5are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents.

11. The compound of any one of claims 1 to 10, or a pharmaceutically acceptable salt thereof, wherein each Rw2is independently selected from C3-7cycloalkyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl, wherein the C3-7cycloalkyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl of Rw2are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents.

12. The compound of any one of claims 1 to 10, or a pharmaceutically acceptable salt thereof, wherein each Rw2is independently selected from cyclopropyl, cyclobutyl, oxazolyl, and tetrahydropyranyl, wherein the cyclopropyl, cyclobutyl, oxazolyl, and tetrahydropyranyl of Rw2are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents.

13. The compound of any one of claims 1 to 12, or a pharmaceutically acceptable salt thereof, wherein each R5Ais independently selected from halo, C1-6alkyl, C1-6haloalkyl, CN, ORa51, C(O)Rb51, and C(O)ORa51; and each Ra51and Rb51is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, and C2-6alkynyl.

14. The compound of any one of claims 1 to 12, or a pharmaceutically acceptable salt thereof, wherein each R5Ais independently selected from halo, C1-6alkyl, and C(O)ORa51; and each Ra51is independently selected from H and C1-6alkyl.

15. The compound of any one of claims 1 to 12, or a pharmaceutically acceptable salt thereof, wherein each R5Ais independently selected from fluoromethyl, and ethoxycarbonyl.

16. The compound of any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof, wherein R5is selected from triazolyl, pyrazolyl, piperidinyl, tetrahydropyranyl, NHRw2, NHC(O)Rw2, NHC(O)ORw2, and NHS(O)2Rw2, wherein the triazolyl, pyrazolyl,piperidinyl, and tetrahydropyranyl of R5are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents; each Rw2is independently selected from cyclopropyl, cyclobutyl, oxazolyl, and tetrahydropyranyl, wherein the cyclopropyl, cyclobutyl, oxazolyl, and tetrahydropyranyl of Rw2are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents; each R5Ais independently selected from halo, C1-6alkyl, and C(O)ORa51; and each Ra51is independently selected from H and C1-6alkyl.

17. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein Cy4is selected from thiazolyl, pyrazolyl, pyridinyl, and pyrimidinyl, wherein the thiazolyl, pyrazolyl, pyridinyl, and pyrimidinyl of Cy4are each optionally substituted with 1, 2, 3, or 4 independently selected R4substituents.

18. The compound of claim 1 or 17, wherein the compound of Formula I is a compound of Formula IIIa, IIIb, IIIc, IIId, IIIe, IIIf, IIIg, IIIh, IIIi, IIIj, IIIk, IIIm, or IIIn:IIIc IIIdIIIn; or a pharmaceutically acceptable salt thereof.

19. The compound of any one of claims 1, 17 and 18, or a pharmaceutically acceptable salt thereof, wherein: each R4is independently selected from halo, oxo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, (4-10 membered heterocycloalkyl)-C1-6alkyl-, ORa4, and C(O)Rb4, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of R4are each optionally substituted with 1, 2, 3, or 4 independently selected R4Asubstituents; each Ra4and Rb4is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, and 4-6 membered heterocycloalkyl; each R4Ais independently selected from halo, oxo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, CN, ORa41, and C(O)Rb41; each Ra41and Rb41is independently selected from H, C1-6alkyl, and C1-6haloalkyl; R5is selected from C1-6alkyl, C3-12cycloalkyl, C6-10aryl, 5-12 membered heteroaryl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, 2,3-dihydrobenzo[b][1,4]dioxinyl, 3,4-dihydro- 2H-benzo[b][1,4]oxazinyl, azaspiro[2.4]heptanyl, ORw2, NRw2Rw3, C(O)Rw2, and C(O)NRw2Rw3; wherein the C1-6alkyl and C6-10aryl of R5are each substituted with 1 Rw1substituent and optionally substituted 1 or 2 independently selected R5Asubstituents; or the C6-10aryl of R5is substituted with 1 Rw5substituent and optionally substituted 1 or 2 independently selected R5Asubstituents; and the C3-12cycloalkyl, 5-12 membered heteroaryl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, 2,3-dihydrobenzo[b][1,4]dioxinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, and azaspiro[2.4]heptanyl of R5are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents; Rw1is selected from C3-12cycloalkyl, 4-12 membered heterocycloalkyl, ORw4, and NHRw4, wherein the C3-12cycloalkyl and 4-12 membered heterocycloalkyl or Rw1are each optionally substituted by 1, 2, 3, or 4 independently selected R5Asubstituents; each Rw2is independently selected from C3-12cycloalkyl, 5-12 membered heteroaryl, and 4-12 membered heterocycloalkyl, wherein the C3-12cycloalkyl, 5-12 membered heteroaryl, and 4-12 membered heterocycloalkyl of Rw2are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents; each Rw3is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, and C2-6alkynyl;each Rw4is independently selected from C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl; Rw5is C1-6alkyl which is substituted with CN or ORa51; each R5Ais independently selected from halo, oxo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, CN, ORa51, and NRc51Rd51, wherein the C1-6alkyl, C2-6alkenyl, and C2-6alkynyl of R5Aare each optionally substituted with ORa52and 1, 2, 3, 4, 5, 6, or 7 independently selected halo groups; each Ra51, Rc51, and Rd51is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, and C2-6alkynyl; and each Ra52is independently selected from H and C1-6alkyl.

20. The compound of any one of claims 1 and 17 to 19, or a pharmaceutically acceptable salt thereof, wherein each R4is independently selected from halo, C1-6alkyl, C6-10aryl, 5-6 membered heteroaryl, 4-10 membered heterocycloalkyl, (4-10 membered heterocycloalkyl)- C1-6alkyl-, ORa4, and C(O)Rb4, wherein the C1-6alkyl, C6-10aryl, 5-6 membered heteroaryl, 4- 10 membered heterocycloalkyl, and (4-10 membered heterocycloalkyl)-C1-6alkyl- of R4are each optionally substituted with 1, 2, 3, or 4 independently selected R4Asubstituents; and each Ra4and Rb4is independently selected from H, C1-6alkyl, C1-6haloalkyl, and 4-6 membered heterocycloalkyl.

21. The compound of any one of claims 1 and 17 to 19, or a pharmaceutically acceptable salt thereof, wherein each R4is independently selected from halo, C1-6alkyl, phenyl, 5-6 membered heteroaryl, 4-10 membered heterocycloalkyl, (4-6 membered heterocycloalkyl)-C1-6 alkyl-, ORa4, and C(O)Rb4, wherein the C1-6alkyl, phenyl, 5-6 membered heteroaryl, 4-10 membered heterocycloalkyl, and (4-6 membered heterocycloalkyl)-C1-6alkyl- of R4are each optionally substituted with 1, 2, 3, or 4 independently selected R4Asubstituents; and each Ra4and Rb4is independently selected from C1-6alkyl and 4-6 membered heterocycloalkyl.

22. The compound of any one of claims 1 and 17 to 19, or a pharmaceutically acceptable salt thereof, wherein each R4is independently selected from fluoro, methyl, trideuteromethyl, isopropyl, methoxy, morpholinylcarbonyl, phenyl, pyrazolyl, pyridinyl, tetrahydropyranyl, piperidinyl, and 2,3-dihydrobenzo[b][1,4]dioxinyl, wherein the methyl, isopropyl, phenyl, pyrazolyl, piperidinyl, and 2,3-dihydrobenzo[b][1,4]dioxinyl of R4are each optionally substituted with 1, 2, 3, or 4 independently selected R4Asubstituents.

23. The compound of any one of claims 1 and 17 to 22, or a pharmaceutically acceptable salt thereof, wherein each R4Ais independently selected from C1-6alkyl, C1-6haloalkyl, CN, ORa41, and C(O)Rb41; and each Ra41and Rb41is independently selected from H and C1-6alkyl.

24. The compound of any one of claims 1 and 17 to 22, or a pharmaceutically acceptable salt thereof, wherein each R4Ais selected from methyl, difluoromethyl, trifluoromethyl, CN, OH, and methylcarbonyl.

25. The compound of any one of claims 1 and 17 to 19, or a pharmaceutically acceptable salt thereof, wherein each R4is independently selected from fluoro, methyl, hydroxymethyl, hydroxyisopropyl, methoxy, (methylcarbonyl)piperidinyl, methylpyrazolyl, cyanophenyl, 2,3- dihydrobenzo[b][1,4]dioxinyl, (difluoromethylazetidinyl)methyl, and morpholinylcarbonyl.

26. The compound of any one of claims 1 and 17 to 25, or a pharmaceutically acceptable salt thereof, wherein R5is selected from C1-6alkyl, C3-7cycloalkyl, phenyl, 5-10 membered heteroaryl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, 2,3-dihydrobenzo[b][1,4]dioxinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, azaspiro[2.4]heptanyl, ORw2, NHRw2, C(O)Rw2, and C(O)NHRw2; wherein the C1-6alkyl and phenyl of R5are each substituted with 1 Rw1substituent and optionally substituted 1 or 2 independently selected R5Asubstituents; or the phenyl of R5is substituted with 1 Rw5substituent and optionally substituted 1 or 2 independently selected R5Asubstituents; and the C3-7cycloalkyl, 5-10 membered heteroaryl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, 2,3-dihydrobenzo[b][1,4]dioxinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, and azaspiro[2.4]heptanyl of R5are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents.

27. The compound of any one of claims 1 and 17 to 25, or a pharmaceutically acceptable salt thereof, wherein R5is selected from –CH2Rw1, C3-7cycloalkyl, -phenyl-Rw1, -phenyl-Rw5, 5-10 membered heteroaryl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, 2,3- dihydrobenzo[b][1,4]dioxinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, azaspiro[2.4]heptanyl, ORw2, NHRw2, C(O)Rw2, and C(O)NHRw2, wherein the C3-7cycloalkyl, phenyl, 5-10 membered heteroaryl, pyrrolidinyl, piperidinyl, 2,3-dihydrobenzo[b][1,4]dioxinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, and azaspiro[2.4]heptanyl of R5are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents.

28. The compound of any one of claims 1 and 17 to 27, or a pharmaceutically acceptable salt thereof, wherein Rw1is selected from C3-7cycloalkyl, 4-7 membered heterocycloalkyl, ORw4, and NHRw4, wherein the C3-7cycloalkyl and 4-7 membered heterocycloalkyl or Rw1are each optionally substituted by 1 or 2 independently selected R5Asubstituents.

29. The compound of any one of claims 1 and 17 to 27, or a pharmaceutically acceptable salt thereof, wherein Rw1is selected from cyclopropyl, fluoropyrrolidinyl, morpholinyl, ORw4, and NHRw4; and Rw4is selected from C1-6haloalkyl and C3-7cycloalkyl.

30. The compound of any one of claims 1 and 17 to 27, or a pharmaceutically acceptable salt thereof, wherein Rw1is selected from cyclopropyl, fluoropyrrolidinyl, morpholinyl, trifluoromethoxy, and cyclopentylamino.

31. The compound of any one of claims 1 and 17 to 30, or a pharmaceutically acceptable salt thereof, wherein Rw2is selected from C3-7cycloalkyl, bicyclic 8-12 membered heteroaryl, monocyclic 4-7 membered heterocycloalkyl, and bicyclic 8-12 membered heterocycloalkyl, wherein the C3-7cycloalkyl, bicyclic 8-12 membered heteroaryl, monocyclic 4-7 membered heterocycloalkyl, and bicyclic 8-12 membered heterocycloalkyl of Rw2are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents.

32. The compound of any one of claims 1 and 17 to 30, or a pharmaceutically acceptable salt thereof, wherein Rw2is selected from cyclobutyl, cyclopentyl, cyclohexyl, quinolinyl, tetrahydropyranyl, piperidinyl, morpholinyl, pyrrolidinyl, and octahydro-2H-pyrido[1,2- a]pyrazinyl, wherein the cyclobutyl, cyclopentyl, cyclohexyl, quinolinyl, tetrahydropyranyl, piperidinyl, morpholinyl, pyrrolidinyl, and octahydro-2H-pyrido[1,2-a]pyrazinyl of Rw2are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents.

33. The compound of any one of claims 1 and 17 to 32, or a pharmaceutically acceptable salt thereof, wherein Rw5is C1-6alkyl which is substituted with CN or ORa51; and Ra51is selected from H and C1-3alkyl.

34. The compound of any one of claims 1 and 17 to 32, or a pharmaceutically acceptable salt thereof, wherein Rw5is selected from cyanomethyl and hydroxymethyl.

35. The compound of any one of claims 1 and 17 to 34, or a pharmaceutically acceptable salt thereof, wherein each R5Ais independently selected from halo, C1-6alkyl, C1-6haloalkyl, CN, ORa51, and NRc51Rd51, wherein the C1-6alkyl is optionally substituted with OH and 1, 2, 3, 4, 5, 6, or 7 independently selected halo groups; and each Ra51, Rc51, and Rd51is independently selected from H and C1-6alkyl.

36. The compound of any one of claims 1 and 17 to 34, or a pharmaceutically acceptable salt thereof, wherein each R5Ais independently selected from chloro, fluoro, methyl, hydroxyisopropyl, hydroxyhexafluoroisopropyl, difluoromethyl, trifluoromethyl, CN, methoxy, ethoxy, and amino.

37. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein Cy4is selected from quinolinyl, imidazo[1,2-b]pyridazinyl, and pyrazolo[1,5-a]pyrimidinyl, wherein the quinolinyl, imidazo[1,2-b]pyridazinyl, and pyrazolo[1,5-a]pyrimidinyl are each optionally substituted with 1, 2, 3, or 4 independently selected R4substituents.

38. The compound of claim 1 or 37, wherein the compound of Formula I is a compound of Formula IVa, IVb, IVc, IVd, IVe, IVf, IVg, IVh, IVi, IVj, IVk, IVm, IVn, IVo, IVp, IVq, IVr, IVs, IVt, IVu, or IVv:IVv or a pharmaceutically acceptable salt thereof.

39. The compound of any one of claims 1, 37, and 38, or a pharmaceutically acceptable salt thereof, wherein: each R4is independently selected from halo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, and C3-7cycloalkyl-C1-6alkyl-, wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl,4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, and C3-7cycloalkyl-C1-6alkyl- of R4is optionally substituted with 1, 2, 3, or 4 independently selected R4Asubstituents; each R4Ais independently selected from halo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, CN, and ORa41; each Ra41is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, and C2-6alkynyl; R5is selected from C3-12cycloalkyl, 5-12 membered heteroaryl, NRw2Rw3, and C(O)Rw2, wherein the C3-12cycloalkyl and 5-12 membered heteroaryl of R5are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents; each Rw2is independently selected from C3-12cycloalkyl and 4-12 membered heterocycloalkyl, wherein the C3-12cycloalkyl and 4-12 membered heterocycloalkyl of Rw2are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents; each Rw3is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, or C2-6alkynyl; each R5Ais independently selected from halo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, CN and ORa51; and each Ra51is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, and C2-6alkynyl.

40. The compound of any one of claims 1 and 37 to 39, or a pharmaceutically acceptable salt thereof, wherein R4is independently selected from halo, C1-6alkyl, C1-6haloalkyl, C3-7cycloalkyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, and C3-7cycloalkyl-C1-6 alkyl-, wherein each C1-6alkyl, C3-7cycloalkyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, and C3-7cycloalkyl-C1-6alkyl- of R4is optionally substituted with 1, 2, 3, or 4 independently selected R4Asubstituents.

41. The compound of any one of claims 1 and 37 to 39, or a pharmaceutically acceptable salt thereof, wherein R4is independently selected from C1-6alkyl, C1-6haloalkyl, C3-7cycloalkyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, and C3-7cycloalkyl-C1-6 alkyl-, wherein each C1-6alkyl, C3-7cycloalkyl, 4-7 membered heterocycloalkyl, 5-6 membered heteroaryl, and C3-7cycloalkyl-C1-6alkyl- of R4is optionally substituted with 1, 2, 3, or 4 R4Asubstituents; each R4Ais independently selected from C1-6haloalkyl, CN, and ORa41; and each Ra41is independently selected from H and C1-6alkyl.

42. The compound of any one of claims 1 and 37 to 39, or a pharmaceutically acceptable salt thereof, wherein R4is selected from methyl, ethyl, isopropyl, trifluoromethyl, cyclopropyl, cyclobutyl, cyclohexyl, tetrahydropyranyl, deuterotetrahydropyranyl, pyridinyl, and cyclopropylmethyl, wherein each methyl, ethyl, isopropyl, isobutyl, cyclopropyl, cyclobutyl, cyclohexyl, tetrahydropyranyl, deuterotetrahydropyranyl, pyridinyl, and cyclopropylmethyl of R4is optionally substituted with 1 or 2 R4Asubstituents independently selected from C1-3haloalkyl, CN, OH, and C1-3alkoxy.

43. The compound of any one of claims 1 and 37 to 42, or a pharmaceutically acceptable salt thereof, wherein R5is selected from C3-7cycloalkyl, 5-6 membered heteroaryl, NHRw2, and C(O)Rw2, wherein the C3-7cycloalkyl and 5-6 membered heteroaryl of R5are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents.

44. The compound of any one of claims 1 and 37 to 42, or a pharmaceutically acceptable salt thereof, wherein R5is selected from cyclopropyl, cyclobutyl, cyclohexyl, pyrazolyl, imidazolyl, pyridinyl, NHRw2, and C(O)Rw2, wherein the cyclopropyl, cyclobutyl, cyclohexyl, pyrazolyl, imidazolyl, and pyridinyl of R5are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents.

45. The compound of any one of claims 1 and 37 to 44, or a pharmaceutically acceptable salt thereof, wherein Rw2is selected from C3-7cycloalkyl, 4-8 membered monocyclic heterocycloalkyl, and 6-10 membered bicyclic heterocycloalkyl, wherein the C3-7cycloalkyl, 4-8 membered monocyclic heterocycloalkyl, and 6-10 membered bicyclic heterocycloalkyl of Rw2are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents.

46. The compound of any one of claims 1 and 37 to 44, or a pharmaceutically acceptable salt thereof, wherein Rw2is selected from cyclopentyl, piperidinyl, morpholinyl, 1,6- diazaspiro[3.3]heptanyl, 3-azabicyclo[3.1.0]hexanyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, and 2-oxa-5-azabicyclo[4.1.0]heptanyl, wherein the cyclopentyl, piperidinyl, morpholinyl, 1,6- diazaspiro[3.3]heptanyl, 3-azabicyclo[3.1.0]hexanyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, and 2-oxa-5-azabicyclo[4.1.0]heptanyl of Rw2are each optionally substituted with 1, 2, 3, or 4 independently selected R5Asubstituents.

47. The compound of any one of claims 1 and 37 to 46, or a pharmaceutically acceptable salt thereof, wherein each R5Ais independently selected from halo, C1-6alkyl, C1-6haloalkyl, CN, and ORa51; and each Ra51is independently selected from H and C1-6alkyl.

48. The compound of any one of claims 1 and 37 to 46, or a pharmaceutically acceptable salt thereof, wherein each R5Ais independently selected from fluoro, methyl, trideuteromethyl, difluoromethyl, trifluoromethyl, CN, and hydroxy.

49. The compound of any one of claims 1 to 48, or a pharmaceutically acceptable salt thereof, wherein R1is C1-6alkyl, which is optionally substituted with 1, 2, or 3 independently selected R1Asubstituents.

50. The compound of any one of claims 1 to 49, or a pharmaceutically acceptable salt thereof, wherein R1is C1-6alkyl.

51. The compound of any one of claims 1 to 49, or a pharmaceutically acceptable salt thereof, wherein R1is methyl or trideuteromethyl.

52. The compound of any one of claims 1 to 51, or a pharmaceutically acceptable salt thereof, wherein Cy2is selected from monocyclic C3-10cycloalkyl, bicyclic C6-10cycloalkyl, spriocyclic C6-10cycloalkyl, monocyclic 4-7 membered heterocycloalkyl, spriocyclic 6-10 membered heterocycloalkyl, and bicyclic 5-10 membered heterocycloalkyl, wherein the monocyclic C3-10cycloalkyl, bicyclic C6-10cycloalkyl, spriocyclic C6-10cycloalkyl, monocyclic 4-7 membered heterocycloalkyl, spriocyclic 6-10 membered heterocycloalkyl, and bicyclic 5- 10 membered heterocycloalkyl are each substituted with 1, 2, 3, or 4 independently selected R2substituents.

53. The compound of any one of claims 1 to 51, or a pharmaceutically acceptable salt thereof, wherein Cy2is selected from cyclobutyl, cyclopentyl, deuterocyclopentyl, cyclohexyl, tetrahydrofuranyl, bicyclo[2.2.1]heptanyl, bicyclo[2.2.2]octanyl, spiro[3.3]heptanyl, 3-azabicyclo[3.1.0]hexanyl, 2-azaspiro[3.3]heptanyl, and 2- azabicyclo[2.2.1]heptanyl, wherein the cyclobutyl, cyclopentyl, deuterocyclopentyl, cyclohexyl, tetrahydrofuranyl, bicyclo[2.2.1]heptanyl, bicyclo[2.2.2]octanyl, spiro[3.3]heptanyl, 3-azabicyclo[3.1.0]hexanyl, 2-azaspiro[3.3]heptanyl, and 2-azabicyclo[2.2.1]heptanyl of Cy2are each optionally substituted by 1, 2, 3 or 4 independently selected R2substituents.

54. The compound of any one of claims 1 to 51, or a pharmaceutically acceptable salt thereof, wherein Cy2is selected from: , , , , ,wherein n is 0, 1, or 2.

55. The compound of any one of claims 1 to 51, or a pharmaceutically acceptable salt thereof, wherein Cy2is selected from:.

56. The compound of any one of claims 1 to 51, or a pharmaceutically acceptable salt thereof, wherein Cy2is selected from:

57. The compound of any one of claims 1 to 56, or a pharmaceutically acceptable salt thereof, wherein each R2is independently selected from halo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, CN, ORa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)ORa2, NRc2C(O)NRc2Rd2, NRc2S(O)Rb2, NRc2S(O)2Rb2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, and S(O)2NRc2Rd2, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, of R2are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents.

58. The compound of any one of claims 1 to 56, or a pharmaceutically acceptable salt thereof, wherein each R2is independently selected from halo, C1-6alkyl, CN, ORa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, NRc2C(O)Rb2, NRc2C(O)ORa2, and NRc2S(O)2Rb2, wherein the C1-6alkyl of R2are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents.

59. The compound of any one of claims 1 to 58, or a pharmaceutically acceptable salt thereof, wherein each Ra2, Rb2, Rc2, and Rd2is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl of Ra2, Rb1, Rc2, and Rd2are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents.

60. The compound of any one of claims 1 to 58, or a pharmaceutically acceptable salt thereof, wherein each Ra2, Rb2, Rc2, and Rd2is independently selected from H, C1-6alkyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl, wherein the C1-6alkyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl,and 4-7 membered heterocycloalkyl of Ra2, Rb1, Rc2, and Rd2are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents.

61. The compound of any one of claims 1 to 58, or a pharmaceutically acceptable salt thereof, wherein each Ra2, Rb2, Rc2, and Rd2is independently selected from H, methyl, trideuteromethyl, ethyl, propynyl, cyclopropyl, cyclobutyl, phenyl, and tetrahydropyranyl, wherein the methyl, ethyl, propynyl, cyclopropyl, cyclobutyl, phenyl, and tetrahydropyranyl of Ra2, Rb1, Rc2, and Rd2are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents.

62. The compound of any one of claims 1 to 56, or a pharmaceutically acceptable salt thereof, wherein each R2is independently selected from halo, C1-6alkyl, CN, ORa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, NRc2C(O)Rb2, NRc2C(O)ORa2, and NRc2S(O)2Rb2, wherein the C1-6alkyl of R2are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents; and each Ra2, Rb2, Rc2, and Rd2is independently selected from H, methyl, ethyl, propynyl, cyclopropyl, cyclobutyl, phenyl, and tetrahydropyranyl, wherein the methyl, trideuteromethyl, ethyl, propynyl, cyclopropyl, cyclobutyl, phenyl, and tetrahydropyranyl of Ra2, Rb1, Rc2, and Rd2are each optionally substituted with 1 or 2 independently selected R2Asubstituents.

63. The compound of any one of claims 1 to 62, or a pharmaceutically acceptable salt thereof, wherein each R2Ais independently selected from halo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, CN, and ORa21.

64. The compound of any one of claims 1 to 62, or a pharmaceutically acceptable salt thereof, wherein each R2Ais independently selected from halo and ORa21; and each Ra21is independently selected from H and C1-6alkyl.

65. The compound of any one of claims 1 to 62, or a pharmaceutically acceptable salt thereof, wherein each R2Ais independently selected from fluoro, hydroxy, and methoxy.

66. The compound of any one of claims 1 to 65, or a pharmaceutically acceptable salt thereof, wherein R3is selected from H and C1-6alkyl.

67. The compound of any one of claims 1 to 65, or a pharmaceutically acceptable salt thereof, wherein R3is H.

68. The compound of any one of claims 1 to 48, or a pharmaceutically acceptable salt thereof, wherein: R1is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; Cy2is selected from monocyclic C3-10cycloalkyl, bicyclic C6-10cycloalkyl, spriocyclic C6-10cycloalkyl, monocyclic 4-7 membered heterocycloalkyl, spriocyclic 6-10 membered heterocycloalkyl, and bicyclic 5-10 membered heterocycloalkyl, wherein the monocyclic C3-10cycloalkyl, bicyclic C6-10cycloalkyl, spriocyclic C6-10cycloalkyl, monocyclic 4-7 membered heterocycloalkyl, spriocyclic 6-10 membered heterocycloalkyl, and bicyclic 5-10 membered heterocycloalkyl are each substituted with 1, 2, 3, or 4 independently selected R2substituents; each R2is independently selected from halo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, CN, ORa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)ORa2, NRc2C(O)NRc2Rd2, NRc2S(O)Rb2, NRc2S(O)2Rb2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, and S(O)2NRc2Rd2, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, of R2are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents; each Ra2, Rb2, Rc2, and Rd2is independently selected from H, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl of Ra2, Rb1, Rc2, and Rd2are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents; each R2Ais independently selected from halo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, CN, and ORa21; each Ra21is independently selected from H and C1-6alkyl; and R3is selected from H and C1-6alkyl.

69. The compound of any one of claims 1 to 48, or a pharmaceutically acceptable salt thereof, wherein: R1is selected from C1-6alkyl; Cy2is selected from monocyclic C3-10cycloalkyl, bicyclic C6-10cycloalkyl, spriocyclic C6-10cycloalkyl, monocyclic 4-7 membered heterocycloalkyl, spriocyclic 6-10 membered heterocycloalkyl, and bicyclic 5-10 membered heterocycloalkyl, wherein the monocyclic C3-10cycloalkyl, bicyclic C6-10cycloalkyl, spriocyclic C6-10cycloalkyl, monocyclic 4-7 memberedheterocycloalkyl, spriocyclic 6-10 membered heterocycloalkyl, and bicyclic 5-10 membered heterocycloalkyl are each substituted with 1, 2, 3, or 4 independently selected R2substituents; each R2is independently selected from halo, C1-6alkyl, CN, ORa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, NRc2C(O)Rb2, NRc2C(O)ORa2, and NRc2S(O)2Rb2, wherein the C1-6alkyl of R2are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents; each Ra2, Rb2, Rc2, and Rd2is independently selected from H, C1-6alkyl, C2-6alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl, wherein the C1-6alkyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl of Ra2, Rb1, Rc2, and Rd2are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents; each R2Ais independently selected from halo, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, CN, and ORa21; each Ra21is independently selected from H and C1-6alkyl; and R3is H.

70. The compound of any one of claims 1 to 48, or a pharmaceutically acceptable salt thereof, wherein: R1is C1-3 alkyl; Cy2is selected from cyclobutyl, cyclopentyl, deuterocyclopentyl, cyclohexyl, tetrahydrofuranyl, bicyclo[2.2.1]heptanyl, bicyclo[2.2.2]octanyl, spiro[3.3]heptanyl, 3- azabicyclo[3.1.0]hexanyl, 2-azaspiro[3.3]heptanyl, and 2-azabicyclo[2.2.1]heptanyl, wherein the cyclobutyl, cyclopentyl, cyclohexyl, tetrahydrofuranyl, bicyclo[2.2.1]heptanyl, bicyclo[2.2.2]octanyl, spiro[3.3]heptanyl, 3-azabicyclo[3.1.0]hexanyl, 2- azaspiro[3.3]heptanyl, and 2-azabicyclo[2.2.1]heptanyl of Cy2are each optionally substituted by 1, 2, 3 or 4 independently selected R2substituents; each R2is independently selected from halo, C1-6alkyl, CN, ORa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, NRc2C(O)Rb2, NRc2C(O)ORa2, and NRc2S(O)2Rb2, wherein the C1-6alkyl of R2are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents; each Ra2, Rb2, Rc2, and Rd2is independently selected from H, methyl, ethyl, propynyl, cyclopropyl, cyclobutyl, phenyl, and tetrahydropyranyl, wherein the methyl, trideuteromethyl, ethyl, propynyl, cyclopropyl, cyclobutyl, phenyl, and tetrahydropyranyl of Ra2, Rb1, Rc2, and Rd2are each optionally substituted with 1, 2, 3, or 4 independently selected R2Asubstituents; each R2Ais independently selected from halo and ORa21;each Ra21is independently selected from H and C1-6alkyl; and R3is H.

71. The compound of claim 1, which is selected from: ethyl 2-((3'-cyano-5-((1-((1R,3R)-3-((methoxycarbonyl)amino)cyclopentyl)-3- methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-6-yl)amino)-[1,1'-biphenyl]-3- yl)amino)oxazole-5-carboxylate; methyl ((1R,3R)-3-(6-((3'-cyano-5-(4-fluorotetrahydro-2H-pyran-4-carboxamido)- [1,1'-biphenyl]-3-yl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(3-(methyl-d3)-6-((4-(1-methyl-1,6-diazaspiro[3.3]heptane-6- carbonyl)-8-(trifluoromethyl)quinolin-2-yl)amino)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((6-(4-(hydroxymethyl)-3-methylphenyl)pyridin-2-yl)amino)-3- methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((6'-methoxy-[2,3'-bipyridin]-6-yl)amino)-3-methyl-2-oxo-2,3- dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((4-(4-cyanopiperidine-1-carbonyl)-8- (trifluoromethyl)quinolin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(3-methyl-6-((6-(3-methyl-1H-indazol-5-yl)pyridin-2-yl)amino)- 2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((6-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)pyridin-2-yl)amino)- 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(3-methyl-2-oxo-6-((6-(quinolin-6-yl)pyridin-2-yl)amino)-2,3- dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((4-(1-hydroxy-3-azabicyclo[3.1.0]hexane-3-carbonyl)-8- (trifluoromethyl)quinolin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(3-methyl-6-((6-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7- yl)pyridin-2-yl)amino)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((4-(2-oxa-5-azabicyclo[2.2.1]heptane-5-carbonyl)-8- (trifluoromethyl)quinolin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl)carbamate;methyl ((1R,3R)-3-(6-((4-(2-oxa-5-azabicyclo[4.1.0]heptane-5-carbonyl)-8- (trifluoromethyl)quinolin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl)carbamate; methyl (3-((1-((1R,3R)-3-((methoxycarbonyl)amino)cyclopentyl)-3-methyl-2-oxo- 2,3-dihydro-1H-imidazo[4,5-c]pyridin-6-yl)amino)-5-(1-methyl-1H-1,2,3-triazol-4- yl)phenyl)carbamate; methyl (3-((1-((1R,3R)-3-((methoxycarbonyl)amino)cyclopentyl)-3-methyl-2-oxo- 2,3-dihydro-1H-imidazo[4,5-c]pyridin-6-yl)amino)-5-(1-methylpiperidin-4- yl)phenyl)carbamate; methyl ((1R,3R)-3-(6-((4-(3,3-difluoropiperidine-1-carbonyl)-8- (trifluoromethyl)quinolin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((3-((R)-2,2-difluorocyclopropane-1-carboxamido)-5- (tetrahydro-2H-pyran-4-yl)phenyl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((6-((3,3-difluorocyclopentyl)amino)-8- (trifluoromethyl)quinolin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((3-(cyclobutanecarboxamido)-5-(tetrahydro-2H-pyran-4- yl)phenyl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(3-(methyl-d3)-6-((6-(1-methyl-1H-pyrazol-4-yl)-8- (trifluoromethyl)quinolin-2-yl)amino)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl (3-((1-((1R,3R)-3-((methoxycarbonyl)amino)cyclopentyl)-3-methyl-2-oxo- 2,3-dihydro-1H-imidazo[4,5-c]pyridin-6-yl)amino)-5-(tetrahydro-2H-pyran-3- yl)phenyl)carbamate; methyl ((1R,3R)-3-(6-((6-((4-cyanocyclohexyl)oxy)pyridin-2-yl)amino)-3-methyl-2- oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(3-methyl-2-oxo-6-((6-(quinolin-6-yloxy)pyridin-2-yl)amino)-2,3- dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl (3-((1-((1r,3r)-3-(cyclopropanecarboxamido)cyclobutyl)-3-methyl-2-oxo-2,3- dihydro-1H-imidazo[4,5-c]pyridin-6-yl)amino)-5-(1-methyl-1H-pyrazol-4- yl)phenyl)carbamate;methyl (3-((1-(6-((ethoxycarbonyl)amino)spiro[3.3]heptan-2-yl)-3-methyl-2-oxo-2,3- dihydro-1H-imidazo[4,5-c]pyridin-6-yl)amino)-5-(1-methyl-1H-pyrazol-4- yl)phenyl)carbamate; methyl (3-((1-(6-(cyclopropanesulfonamido)spiro[3.3]heptan-2-yl)-3-methyl-2-oxo- 2,3-dihydro-1H-imidazo[4,5-c]pyridin-6-yl)amino)-5-(1-methyl-1H-pyrazol-4- yl)phenyl)carbamate; methyl 6-(6-((3-((methoxycarbonyl)amino)-5-(1-methyl-1H-pyrazol-4- yl)phenyl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)-2- azaspiro[3.3]heptane-2-carboxylate; methyl (3-((1-((1r,3r)-3-cyanocyclobutyl)-3-methyl-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-6-yl)amino)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)carbamate; methyl (3-((1-((1r,3r)-3-((methoxycarbonyl)amino)-3-methylcyclobutyl)-3-methyl-2- oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-6-yl)amino)-5-(1-methyl-1H-pyrazol-4- yl)phenyl)carbamate; methyl (R)-(3-((1-(3,3-difluorocyclopentyl)-3-methyl-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-6-yl)amino)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)carbamate; methyl (3-((1-((1R,3S)-3-fluorocyclopentyl)-3-methyl-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-6-yl)amino)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)carbamate; methyl ((1R,3R)-3-(3-methyl-6-((6-(1-methyl-1H-pyrazol-4-yl)quinolin-2-yl)amino)- 2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(3-methyl-6-((8-(1-methyl-1H-pyrazol-4-yl)quinolin-2-yl)amino)- 2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(3-methyl-6-((3-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2- b]pyridazin-6-yl)amino)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(3-methyl-6-((2-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5- a]pyrimidin-5-yl)amino)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(3-methyl-6-((3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5- a]pyrimidin-5-yl)amino)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(3-methyl-2-oxo-6-((6-((tetrahydro-2H-pyran-4-yl)oxy)pyridin-2- yl)amino)-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate;methyl ((1R,3R)-3-(3-methyl-6-((3-(1-methyl-1H-imidazol-5-yl)imidazo[1,2- b]pyridazin-6-yl)amino)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl (1R,5S)-6-(6-((3-((methoxycarbonyl)amino)-5-(1-methyl-1H-pyrazol-4- yl)phenyl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)-3- azabicyclo[3.1.0]hexane-3-carboxylate; methyl (3-((1-(2-acetyl-2-azabicyclo[2.2.1]heptan-5-yl)-3-methyl-2-oxo-2,3-dihydro- 1H-imidazo[4,5-c]pyridin-6-yl)amino)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)carbamate; methyl ((1R,3R)-3-(6-((3-((3,3-difluorocyclobutane)-1-sulfonamido)-5-(tetrahydro- 2H-pyran-4-yl)phenyl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl (3-((1-(4-((methoxycarbonyl)amino)-4-methylcyclohexyl)-3-methyl-2-oxo- 2,3-dihydro-1H-imidazo[4,5-c]pyridin-6-yl)amino)-5-(1-methyl-1H-pyrazol-4- yl)phenyl)carbamate; 2-methoxyethyl ((1R,3R)-3-(6-((3-((cyclobutoxycarbonyl)amino)-5-(1-methyl-1H- pyrazol-4-yl)phenyl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((3-((cyclobutoxycarbonyl)amino)-5-(tetrahydro-2H-pyran-4- yl)phenyl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; cyclobutyl ((1R,3R)-3-(6-((3-((cyclobutoxycarbonyl)amino)-5-(1-methyl-1H-pyrazol- 4-yl)phenyl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; ethyl ((1R,3R)-3-(6-((3-((cyclobutoxycarbonyl)amino)-5-(1-methyl-1H-pyrazol-4- yl)phenyl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; prop-2-yn-1-yl ((1R,3R)-3-(6-((3-((cyclobutoxycarbonyl)amino)-5-(1-methyl-1H- pyrazol-4-yl)phenyl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; tetrahydro-2H-pyran-4-yl ((1R,3R)-3-(6-((3-((cyclobutoxycarbonyl)amino)-5-(1- methyl-1H-pyrazol-4-yl)phenyl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl)carbamate; 4-fluorophenyl ((1R,3R)-3-(6-((3-((cyclobutoxycarbonyl)amino)-5-(1-methyl-1H- pyrazol-4-yl)phenyl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate;methyl ((1R,3R)-3-(6-((6-cyclopropylpyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3- dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((6-(3-cyanophenyl)-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2- yl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(3-(methyl-d3)-6-((4-(morpholine-4-carbonyl)-8- (trifluoromethyl)quinolin-2-yl)amino)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((3-((methoxycarbonyl)amino)-5-(1-methyl-1H-pyrazol-4- yl)phenyl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((3-cyclopropylimidazo[1,2-b]pyridazin-6-yl)amino)-3- (methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((3-((cyclopropoxycarbonyl)amino)-5-methoxyphenyl)amino)- 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((3-((cyclobutoxycarbonyl)amino)-5-(1-methyl-1H-pyrazol-4- yl)phenyl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((3-(cyclopropanecarboxamido)-5-(1-methyl-1H-pyrazol-4- yl)phenyl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(3-(methyl-d3)-6-((8-(1-methylcyclopropyl)quinolin-2-yl)amino)- 2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((3-(3-fluoro-1-(methyl-d3)-1H-pyrazol-4-yl)imidazo[1,2- b]pyridazin-6-yl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((4-(cyclobutoxymethyl)-6-(2,3-dihydrobenzo[b][1,4]dioxin-6- yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((6-(3-aminopyrrolidin-1-yl)pyridin-2-yl)amino)-3-methyl-2- oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((4-((cyclopentylamino)methyl)-6-(2,3- dihydrobenzo[b][1,4]dioxin-6-yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate;methyl ((1R,3R)-3-(3-methyl-2-oxo-6-((2-(piperidin-1-yl)pyrimidin-4-yl)amino)-2,3- dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((2'-methoxy-4-methyl-[2,4'-bipyridin]-6-yl)amino)-3-methyl- 2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(3-methyl-2-oxo-6-((4-(pyridin-4-yl)thiazol-2-yl)amino)-2,3- dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((3-fluoro-6'-(trifluoromethyl)-[2,3'-bipyridin]-6-yl)amino)-3- methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((6-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-(((S)-3- fluoropyrrolidin-1-yl)methyl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((6-(4-(cyanomethyl)phenyl)-5-fluoropyridin-2-yl)amino)-3- methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((6-(4-cyclopropylphenyl)-5-fluoropyridin-2-yl)amino)-3- methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((5-fluoro-6-(4-(trifluoromethoxy)phenyl)pyridin-2-yl)amino)- 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((6-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4- (morpholinomethyl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((2-(2-methoxypyridin-4-yl)pyrimidin-4-yl)amino)-3-(methyl- d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((6-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-(octahydro-2H- pyrido[1,2-a]pyrazine-2-carbonyl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1Himidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((2-(5-azaspiro[2.4]heptan-5-yl)pyrimidin-4-yl)amino)-3- methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((2-(3,3-difluoropyrrolidin-1-yl)pyrimidin-4-yl)amino)-3- methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(3-methyl-2-oxo-6-((2-(4-(trifluoromethyl)piperidin-1- yl)pyrimidin-4-yl)amino)-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((6-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-((R)-3- fluoropyrrolidine-1-carbonyl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate;methyl ((1R,3R)-3-(3-methyl-2-oxo-6-((1-(pyridin-4-yl)-1H-pyrazol-3-yl)amino)-2,3- dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((6-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-(morpholine-4- carbonyl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((2-((3,3-difluorocyclopentyl)amino)pyrimidin-4-yl)amino)-3- methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((2-(3,3-difluoropyrrolidin-1-yl)-6-methylpyrimidin-4- yl)amino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(3-methyl-2-oxo-6-((2-((tetrahydro-2H-pyran-4- yl)amino)pyrimidin-4-yl)amino)-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(3-methyl-2-oxo-6-((6-(piperidine-1-carbonyl)pyridin-2- yl)amino)-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; and methyl ((1R,3R)-3-(6-((6-(cyclohexylcarbamoyl)pyridin-2-yl)amino)-3-methyl-2- oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; or a pharmaceutically acceptable salt thereof.

72. A compound, which is selected from: cyclobutyl (3-((1-cyclopentyl-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin- 6-yl)amino)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)carbamate; cyclobutyl (3-((1-cyclopentyl-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin- 6-yl)amino)-5-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)carbamate; and cyclobutyl (3-(1-cyclopropyl-1H-pyrazol-4-yl)-5-((3-methyl-2-oxo-1- (tetrahydrofuran-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)carbamate; or a pharmaceutically acceptable salt thereof.

73. The compound of claim 1, which is selected from: methyl ((1R,3R)-3-(6-((1-(2-methoxyethyl)-3-(1-(trifluoromethyl)-1H-pyrazol-4-yl)- 1H-pyrrolo[3,2-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((3-(1-(difluoromethyl)-1H-pyrazol-4-yl)-1-methyl-2-oxo-7-(4- (trifluoromethyl)pyridin-3-yl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)amino)-3-(methyl- d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate;N-(6-(3-(methyl-d3)-6-((4-(morpholine-4-carbonyl)-8-(trifluoromethyl)quinolin-2- yl)amino)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)spiro[3.3]heptan-2- yl)cyclopropanecarboxamide; N-((1s,4s)-1-methyl-4-(3-(methyl-d3)-6-((2-methyl-3-(1-(trifluoromethyl)-1H- pyrazol-4-yl)-2H-pyrazolo[4,3-b]pyridin-5-yl)amino)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclohexyl)cyclopropanecarboxamide; N-((1S,3R)-3-(6-((6-(5-chlorothiazol-2-yl)-4-(2-hydroxypropan-2-yl)pyridin-2- yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)-1- methylcyclopentyl)cyclopropanecarboxamide; methyl ((1R,3R)-3-(6-((6-(5-chlorothiazol-2-yl)-4-(2-hydroxypropan-2-yl)pyridin-2- yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((4-(2-hydroxypropan-2-yl)-6-(1-methyl-1H-pyrazol-4-yl)-8- (trifluoromethyl)quinolin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((4-(2-hydroxypropan-2-yl)-6-(2-(trifluoromethyl)thiazol-5- yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((8-(2-cyanopropan-2-yl)-4-(morpholine-4-carbonyl)quinolin- 2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((3-(1-(difluoromethyl)-1H-pyrazol-4-yl)-2-methyl-8-(4- (trifluoromethyl)pyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)amino)-3-(methyl-d3)-2-oxo-2,3- dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl-3-d)carbamate; methyl ((1R,3R)-3-(6-((5-methoxy-6-(5-(trifluoromethyl)thiazol-2-yl)pyridin-2- yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((6-(5-(2-hydroxypropan-2-yl)thiazol-2-yl)-4-methylpyridin-2- yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((4-(2-hydroxypropan-2-yl)-6-(5-(trifluoromethyl)thiazol-2- yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate;methyl ((1R,3R)-3-(6-((4-((3-(difluoromethyl)azetidin-1-yl)methyl)-6-(5- (trifluoromethyl)thiazol-2-yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((6-cyclobutoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-(morpholine- 4-carbonyl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin- 1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((2-(5-(difluoromethyl)thiophen-2-yl)-6- (hydroxymethyl)pyrimidin-4-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((6-(5-(difluoromethyl)thiophen-2-yl)-4-(morpholine-4- carbonyl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((4-(1-acetylpiperidin-4-yl)-6-(5-(trifluoromethyl)thiazol-2- yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; 6-((3-(1-(difluoromethyl)-1H-pyrazol-4-yl)-2-methyl-8-(4-(trifluoromethyl)pyridin-3- yl)imidazo[1,2-b]pyridazin-6-yl)amino)-1-((1r,3r)-3-(2-hydroxypropan-2-yl)cyclobutyl)-3- (methyl-d3)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one; methyl ((1R,3R)-3-(6-((6-(5-(2-hydroxypropan-2-yl)thiazol-2-yl)-4-(1-methyl-1H- pyrazol-4-yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin- 1-yl)cyclopentyl)carbamate; and methyl ((1R,3R)-3-(3-(methyl-d3)-2-oxo-6-((6-(4-(trifluoromethyl)-1H-pyrazol-1- yl)pyridin-2-yl)amino)-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; or a pharmaceutically acceptable salt thereof.

74. The compound of claim 1, which is selected from: methyl ((1R,3R)-3-(3-(methyl-d3)-2-oxo-6-((1-(tetrahydro-2H-pyran-4-yl)-3-(1- (trifluoromethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)amino)-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((1-(2-hydroxy-2-methylpropyl)-3-(1-(trifluoromethyl)-1H- pyrazol-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((3R)-3-(3-(methyl-d3)-2-oxo-6-((1-(tetrahydro-2H-pyran-4-yl)-3-(1- (trifluoromethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)amino)-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl-1-d)carbamate;methyl ((3R)-3-(3-(methyl-d3)-2-oxo-6-((1-(tetrahydro-2H-pyran-4-yl-4-d)-3-(1- (trifluoromethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)amino)-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl-1-d)carbamate; methyl ((3R)-3-(6-((1-(1-cyanocyclopropyl)-3-(1-(trifluoromethyl)-1H-pyrazol-4-yl)- 1H-pyrrolo[3,2-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl-1-d)carbamate; methyl ((1R,3R)-3-(6-((1-((1-cyanocyclopropyl)methyl)-3-(1-(difluoromethyl)-1H- pyrazol-4-yl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo- 2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((3-(1-(difluoromethyl)-1H-pyrazol-4-yl)-7-(2-hydroxypropan- 2-yl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; N-((1R,3R)-1-methyl-3-(3-(methyl-d3)-6-((4-(morpholine-4-carbonyl)-8- (trifluoromethyl)quinolin-2-yl)amino)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)cyclopropanecarboxamide; N-((1S,3R)-3-(6-((7-(hydroxymethyl)-2-methyl-3-(1-(trifluoromethyl)-1H-pyrazol-4- yl)-2H-pyrazolo[4,3-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)-1-methylcyclopentyl)cyclopropanecarboxamide; methyl ((1R,3R)-3-(6-((1-(2-hydroxy-2-methylpropyl)-3-(1-(trifluoromethyl)-1H- pyrazol-4-yl)-1H-pyrazolo[4,3-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; N-((1S,3R)-3-(6-((1-(2-hydroxy-2-methylpropyl)-3-(1-(trifluoromethyl)-1H-pyrazol- 4-yl)-1H-pyrazolo[4,3-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)-1-methylcyclopentyl)cyclopropanecarboxamide; N-((1s,4s)-4-(6-((1-(2-hydroxy-2-methylpropyl)-3-(1-(trifluoromethyl)-1H-pyrazol-4- yl)-1H-pyrazolo[4,3-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)-1-methylcyclohexyl)cyclopropanecarboxamide; N-((1S,3R)-3-(6-((2-((1s,3s)-3-hydroxycyclobutyl)-3-(1-(trifluoromethyl)-1H- pyrazol-4-yl)-2H-pyrazolo[4,3-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)-1-methylcyclopentyl)cyclopropanecarboxamide; methyl ((1R,3R)-3-(6-((2-(2-hydroxy-2-methylpropyl)-3-(1-(trifluoromethyl)-1H- pyrazol-4-yl)-2H-pyrazolo[4,3-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate;N-((1S,3R)-3-(6-((2-(2-hydroxy-2-methylpropyl)-3-(1-(trifluoromethyl)-1H-pyrazol- 4-yl)-2H-pyrazolo[4,3-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)-1-methylcyclopentyl)cyclopropanecarboxamide; methyl ((3R)-3-(6-((1-(2-hydroxy-2-methylpropyl)-3-(1-(trifluoromethyl)-1H- pyrazol-4-yl)-1H-pyrazolo[4,3-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl-1-d)carbamate; methyl ((3R)-3-(6-((1-(2-hydroxy-2-methylpropyl)-3-(1-(trifluoromethyl)-1H- pyrazol-4-yl)-1H-pyrazolo[4,3-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl-1-d)carbamate; N-((1s,4s)-4-(6-((1-((1r,4r)-4-hydroxycyclohexyl)-3-(1-(trifluoromethyl)-1H-pyrazol- 4-yl)-1H-pyrazolo[4,3-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)-1-methylcyclohexyl)cyclopropanecarboxamide; N-((1s,4s)-1-methyl-4-(3-(methyl-d3)-6-((2-methyl-7-(morpholine-4-carbonyl)-3-(1- (trifluoromethyl)-1H-pyrazol-4-yl)-2H-pyrazolo[4,3-b]pyridin-5-yl)amino)-2-oxo-2,3- dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclohexyl)cyclopropanecarboxamide; methyl ((1S,3R)-3-(6-((1-(2-hydroxy-2-methylpropyl)-3-(1-(trifluoromethyl)-1H- pyrazol-4-yl)-1H-pyrazolo[4,3-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)-1-methylcyclopentyl)carbamate; N-((1S,3R)-3-(6-((1-(2-hydroxy-2-methylpropyl)-3-(1-(trifluoromethyl)-1H-pyrazol- 4-yl)-1H-pyrazolo[4,3-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)-1-methylcyclopentyl)acetamide; methyl ((3R)-3-(6-((7-(2-hydroxypropan-2-yl)-3-(1-(trifluoromethyl)-1H-pyrazol-4- yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl-1-d)carbamate; methyl ((3R)-3-(6-((4-(2-hydroxypropan-2-yl)-1-(1-(trifluoromethyl)-1H-pyrazol-4- yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl-1-d)carbamate; methyl ((3R)-3-(3-(methyl-d3)-2-oxo-6-((1-(tetrahydro-2H-pyran-4-yl)-3-(1- (trifluoromethyl)-1H-pyrazol-4-yl)-1H-pyrazolo[4,3-b]pyridin-5-yl)amino)-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl-1-d)carbamate; methyl ((3R)-3-(6-((1-((1-cyanocyclopropyl)methyl)-3-(1-(trifluoromethyl)-1H- pyrazol-4-yl)-1H-pyrazolo[4,3-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl-1-d)carbamate;methyl ((3R)-3-(6-((2-((1-cyanocyclopropyl)methyl)-3-(1-(trifluoromethyl)-1H- pyrazol-4-yl)-2H-pyrazolo[4,3-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl-1-d)carbamate; methyl ((1R,3R)-3-(3-(methyl-d3)-6-((6-methyl-4-(morpholine-4-carbonyl)-8- (trifluoromethyl)quinolin-2-yl)amino)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; N-((1S,3R)-3-(6-((6-(5-chlorothiazol-2-yl)-4-(2-hydroxypropan-2-yl)pyridin-2- yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)-1- methylcyclopentyl)acetamide; 4-(6-((4-(2-hydroxypropan-2-yl)-6-(5-(trifluoromethyl)thiazol-2-yl)pyridin-2- yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)-N-(methyl- d3)bicyclo[2.2.2]octane-1-carboxamide; N-cyclopropyl-4-(6-((4-(2-hydroxypropan-2-yl)-6-(5-(trifluoromethyl)thiazol-2- yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)bicyclo[2.2.2]octane-1-carboxamide; 4-(6-((4-(2-hydroxypropan-2-yl)-6-(5-(trifluoromethyl)thiazol-2-yl)pyridin-2- yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)bicyclo[2.2.2]octane-1-carboxamide; N-(4-(6-((4-(2-hydroxypropan-2-yl)-6-(5-(trifluoromethyl)thiazol-2-yl)pyridin-2- yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)bicyclo[2.2.2]octan-1-yl)acetamide; 4-(6-((4-(2-hydroxypropan-2-yl)-6-(5-(trifluoromethyl)thiazol-2-yl)pyridin-2- yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)bicyclo[2.2.1]heptane-1-carboxamide; N-(4-(6-((4-(2-hydroxypropan-2-yl)-6-(5-(trifluoromethyl)thiazol-2-yl)pyridin-2- yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)bicyclo[2.2.1]heptan-1-yl)acetamide; N-((1S,3R)-3-(6-((4-(2-hydroxypropan-2-yl)-6-(5-(trifluoromethyl)thiazol-2- yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)-1- methylcyclopentyl)propionamide; methyl ((1R,3R)-3-(6-((4-(2-hydroxypropan-2-yl)-6-(5-(2-hydroxypropan-2- yl)thiazol-2-yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl)carbamate;methyl ((1R,3R)-3-(6-((6-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)thiazol-2- yl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate; N-((1S,3R)-3-(6-((4-(2-hydroxypropan-2-yl)-6-(2-(trifluoromethyl)thiazol-5- yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)-1- methylcyclopentyl)acetamide; methyl ((1R,3R)-3-(6-((6-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)thiazol-2- yl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl-1-d)carbamate; methyl ((1R,3R)-3-(6-((6-(5-(2-hydroxypropan-2-yl)thiazol-2-yl)-4-methylpyridin-2- yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl-1- d)carbamate; methyl ((1R,3R)-3-(6-((5-fluoro-6-(5-(2-hydroxypropan-2-yl)thiazol-2-yl)-4- methylpyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl-1-d)carbamate; methyl ((1R,3R)-3-(6-((6-(5-(2-hydroxypropan-2-yl)thiazol-2-yl)-4-(methyl- d3)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl-1-d)carbamate; N-((1S,3R)-3-(6-((4-(2-hydroxypropan-2-yl)-6-(2-isopropoxythiazol-5-yl)pyridin-2- yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)-1- methylcyclopentyl)acetamide; N-((1S,3R)-3-(6-((4-(2-hydroxypropan-2-yl)-6-(2-methoxythiazol-5-yl)pyridin-2- yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)-1- methylcyclopentyl)acetamide; N-((1S,3R)-3-(6-((6-(2-ethoxythiazol-5-yl)-4-(2-hydroxypropan-2-yl)pyridin-2- yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)-1- methylcyclopentyl)acetamide; methyl ((1R,3R)-3-(6-((6'-(5-(difluoromethyl)thiophen-2-yl)-4-(trifluoromethyl)- [3,4'-bipyridin]-2'-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl)carbamate; methyl ((1S,2S,4S)-2-hydroxy-4-(6-((4-(2-hydroxypropan-2-yl)-6-(5- (trifluoromethyl)thiazol-2-yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl)carbamate;methyl ((1R,3R)-3-(6-((4-(2-hydroxypropan-2-yl)-6-(5-(trifluoromethyl)thiazol-2- yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl-3-d)carbamate; methyl ((1R,3R)-3-(3-(methyl-d3)-6-((4-(1-methylpiperidin-4-yl)-6-(5- (trifluoromethyl)thiazol-2-yl)pyridin-2-yl)amino)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((4-(2-hydroxypropan-2-yl)-6-(5-(trifluoromethyl)thiazol-2- yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl-1-d)carbamate; methyl ((1S,3R)-3-(6-((4-(2-hydroxypropan-2-yl)-6-(5-(trifluoromethyl)thiazol-2- yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl-1-d)carbamate; methyl ((1S,3R)-3-(6-((3-(1-(difluoromethyl)-1H-pyrazol-4-yl)-2-methyl-8-(4- (trifluoromethyl)pyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)amino)-3-(methyl-d3)-2-oxo-2,3- dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentyl-1-d)carbamate; methyl ((1R,3R)-3-(6-((6-(5-(2-hydroxypropan-2-yl)thiazol-2-yl)-4-(tetrahydro-2H- pyran-4-yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin- 1-yl)cyclopentyl)carbamate; methyl ((1R,3R)-3-(6-((6-(5-(2-hydroxypropan-2-yl)thiazol-2-yl)-4-(tetrahydro-2H- pyran-4-yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin- 1-yl)cyclopentyl-1-d)carbamate; methyl ((1S,3R)-3-(6-((6-(5-(2-hydroxypropan-2-yl)thiazol-2-yl)-4-(tetrahydro-2H- pyran-4-yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin- 1-yl)cyclopentyl-1-d)carbamate; methyl ((1R,3R)-3-(6-((6'-(5-(2-hydroxypropan-2-yl)thiazol-2-yl)-4- (trifluoromethyl)-[3,4'-bipyridin]-2'-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl-1-d)carbamate; methyl ((1S,3R)-3-(6-((6'-(5-(2-hydroxypropan-2-yl)thiazol-2-yl)-4-(trifluoromethyl)- [3,4'-bipyridin]-2'-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1- yl)cyclopentyl-1-d)carbamate; methyl ((1R,3R)-3-(6-((6-(5-(2-hydroxypropan-2-yl)thiazol-2-yl)-4-(1- methylpiperidin-4-yl)pyridin-2-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H-imidazo[4,5- c]pyridin-1-yl)cyclopentyl-1-d)carbamate;methyl ((1R,3R)-3-(6-((6'-(5-(2-hydroxypropan-2-yl)thiazol-2-yl)-2- (trifluoromethyl)-[3,4'-bipyridin]-2'-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl-1-d)carbamate; N-((1S,3R)-3-(6-((3-(1-(difluoromethyl)-1H-pyrazol-4-yl)-2-methyl-8-(4- (trifluoromethyl)pyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)amino)-3-(methyl-d3)-2-oxo-2,3- dihydro-1H-imidazo[4,5-c]pyridin-1-yl)-1-methylcyclopentyl)acetamide; and methyl ((1R,3R)-3-(6-((3-(1-(difluoromethyl)-1H-pyrazol-4-yl)-7-(2-hydroxypropan- 2-yl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)amino)-3-(methyl-d3)-2-oxo-2,3-dihydro-1H- imidazo[4,5-c]pyridin-1-yl)cyclopentyl-1-d)carbamate; or a pharmaceutically acceptable salt thereof.

75. The compound of any of claims 1 to 74, or a pharmaceutically acceptable salt thereof, wherein the compound is deuterated.

76. A pharmaceutical composition, comprising a compound of any one of claims 1 to 75, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

77. A method of inhibiting an activity of the V617F variant of JAK2 kinase, comprising contacting the kinase with a compound of any one of claims 1 to 75, or a pharmaceutically acceptable salt thereof.

78. A method of treating cancer in a patient in need thereof, the method comprising administering to the patient a therapeutically effective amount of a compound of any one of claims 1 to 75, or a pharmaceutically acceptable salt thereof.

79. The method of claim 78, wherein the cancer is selected from bladder cancer, breast cancer, cervical cancer, colorectal cancer, cancer of the small intestine, colon cancer, rectal cancer, cancer of the anus, endometrial cancer, gastric cancer, head and neck cancer, kidney cancer, liver cancer, lung cancer, ovarian cancer, prostate cancer, testicular cancer, uterine cancer, vulvar cancer, esophageal cancer, gall bladder cancer, pancreatic cancer, stomach cancer, thyroid cancer, parathyroid cancer, neuroendocrine cancer, skin cancer, and brain cancer.

80. The method of claim 78, wherein the cancer is a hematological cancer.

81. The method of claim 78, wherein the cancer is selected from leukemia, lymphoma, multiple myeloma, chronic lymphocytic lymphoma, adult T cell leukemia, acute myeloid leukemia, B-cell lymphoma, cutaneous T-cell lymphoma, acute myelogenous leukemia, Hodgkin’s or non-Hodgkin’s lymphoma, a myeloproliferative neoplasm), myelodysplastic syndrome, chronic eosinophilic leukemia, Waldenstrom's Macroglubulinemia, hairy cell lymphoma, chronic myelogenic lymphoma, acute lymphoblastic lymphoma, AIDS-related lymphoma, and Burkitt's lymphoma.

82. A method of treating a myeloproliferative disorder in a patient in need thereof, the method comprising administering to the patient a therapeutically effective amount of a compound of any one of claims 1 to 75, or a pharmaceutically acceptable salt thereof.

83. The method of claim 82, wherein the myeloproliferative disorder is selected from polycythemia vera, essential thrombocythemia, myelofibrosis with myeloid metaplasia, primary myelofibrosis, post- essential thrombocythemia myelofibrosis, post polycythemia vera myelofibrosis, chronic myelogenous leukemia, chronic myelomonocytic leukemia, hypereosinophilic syndrome, and systemic mast cell disease.

84. A method of treating myelodysplastic syndrome in a patient in need thereof, the method comprising administering to the patient a therapeutically effective amount of a compound of any one of claims 1 to 75, or a pharmaceutically acceptable salt thereof.