Sensor and measurement method for converting chemical and / or biochemical information from at least one analyte
Patent Information
- Application Number
- HK62026126549
- Authority / Receiving Office
- HK · HK
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-08-08
- Filing Date
- 2026-07-23
- Publication Date
- 2026-09-25
- Estimated Expiration
- 2044-08-07
Smart Images
Figure 00000000_0000_ABST
Abstract
Description
The present invention relates to a sensor (1) for converting chemical and / or biochemical information of at least one analyte (90) in a sample (9) into a measurement signal, the sensor comprising: at least three cantilever arms (2, 3), each of the cantilever arms (2, 3) having a base and a deformable portion, and wherein first and second transducers (200, 220, 300, 320) are disposed on each of the cantilever arms (2, 3), wherein at least two of the at least three cantilever arms (2, 3) together with their respective transducers (200, 220, 300, 320) form a measurement tuple; a multiplexer (10) configured to receive control signals from a control signal generator (8) to contact the transducers (200, 220, 300, 320) of the cantilever arms (2, 3) corresponding to the measurement tuple of the control signal; and an evaluation unit (12). The evaluation unit converts the chemical and / or biochemical information of the analyte (90) into a measurement signal based on the detected electrical signal from the contacted measurement elements and outputs it. (Summary)
Claims
Claims 1 . Sensor (1) for converting chemical and / or biochemical information of at least one analyte (90) in a sample (9) into a measurement signal, comprising at least three cantilevers (2, 3), each of the cantilevers (2, 3) having a base and a deformable part, and a first and a second transducer (200, 220, 300, 320) being arranged on each of the cantilevers (2, 3), at least two of the at least three cantilevers (2, 3) forming a measurement tuple with the associated transducers (200, 220, 300, 320), a multiplexer (10) configured to receive a control signal from a control signal transmitter (8) in order to contact the transducers (200, 220, 300, 320) of the cantilevers (2, 3) of the measurement tuple corresponding to the control signal, and an evaluation unit (12) which, on the basis of the detected electrical signals of the contacted measuring tuple, converts and outputs the chemical and / or biochemical information of the analyte (90) into a measuring signal.
2. Sensor (1) according to claim 1, characterized in that the cantilevers (2, 3) of different measuring tuples have different geometries and / or different materials.
3. Sensor according to claim 1 or 2, characterized by a control signal transmitter (8) which has a database with the measurement tuples and is configured to send a control signal to the multiplexer (10), wherein preferably the database and / or the control signal is encrypted.
4. Sensor (1) according to one of the preceding claims, characterized in that the transducers (200, 220, 300, 320) of the cantilevers (2, 3) of the measuring tuple are designed and configured to output an electrical signal corresponding to the occurrence and / or the concentration and / or the amount of the analyte (90) in the sample (9).
5. Sensor (1) according to one of the preceding claims, characterized in that a receptor layer for selectively absorbing the analyte is applied at least on the deformable part of at least one of the cantilevers (2), thereby forming a test cantilever (2), and / or a reference layer for selectively not absorbing the analyte is applied at least on the deformable part of at least one of the cantilevers (3), thereby forming a reference cantilever (3).
6. Sensor (1) according to claim 5, characterized in that at least one test cantilever (2) and at least one reference cantilever (3) with the associated transducers (200, 220, 300, 320) form a measurement tuple specific for the analyte.
7. Sensor (1) according to claim 6, characterized in that a measuring tuple comprises at least one test cantilever (2) and at least two reference cantilevers (3) with the respectively associated transducers, and / or a measuring tuple comprises at least two test cantilevers (2) and at least one reference cantilever (3) with the respectively associated transducers, and / or a measuring tuple comprises at least two test cantilevers (2) and at least two reference cantilevers (3) with the respectively associated transducers.
8. Sensor (1) according to one of the preceding claims, characterized in that a first measuring tuple is sensitive to a first analyte (90) and a second measuring tuple is sensitive to a second analyte (90') different from the first analyte (90), wherein preferably a plurality of measuring tuples is provided, wherein in each case at least one measuring tuple is sensitive to a specific analyte.
9. A method for converting chemical and / or biochemical information of an analyte (90) in a sample (9) into a measurement signal using a sensor (1) according to one of the preceding claims, comprising the following steps: Selecting at least one measurement tuple specific for the analyte with the signal generator (8), Contacting the cantilevers (2, 3) of the measuring tuple with the multiplexer (10), Detecting the electrical signals of the transducers (200, 220, 300, 320) of the contacted measuring tuple with the evaluation unit (12), Converting the chemical and / or biochemical information of the analyte with the measurement tuple specific for the respective analyte into a measurement signal with the evaluation unit (12), and Outputting a measurement signal with the evaluation unit (12).
10. The method according to claim 9, characterized in that the method is carried out for at least two different analytes with at least two measuring tuples specific for the different analytes, wherein the contacting of the different measuring tuples is preferably carried out sequentially or simultaneously.
11. Method according to claim 9 or 10, characterized in that the measurement signals for an analyte are output integrally on the basis of several measurement tuples, or that the individual measurement signals of the individual measurement tuples are output.
12. The method according to any one of claims 9 to 11, wherein the output of the measurement signal comprises a statistical analysis.
13. A method for producing a sensor according to any one of claims 1 to 8 comprising the following steps Manufacturing of the cantilevers (2, 3), Manufacturing of the transducers (200, 220, 300, 320) on the cantilevers (2, 3), Characterization of the cantilevers (2, 3) and the associated transducers (200, 220, 300, 320), Assigning the cantilevers (2, 3) with the transducers (200, 220, 300, 320) to a measurement tuple based on the characterization, Covering the cantilevers (2, 3) of a measuring tuple with reference or test layers for a specific analyte (90).
14. Method according to claim 13, characterized in that the cantilevers (2, 3) of the sensor (1) are manufactured in one piece from a substrate, or the sensor (1) is assembled from cantilevers (2, 3) made of the same substrates, or the sensor (1) is assembled from cantilevers (2, 3) made of different substrates.
15. The method according to claim 13 or 14, characterized in that the characterization comprises determining the natural frequencies of the cantilevers (2, 3) and / or determining the resistances of the transducers (200, 220, 300, 320) and / or determining the geometry of the cantilevers (2, 3).
16. Method according to one of claims 13 to 15, comprising the step: - storing the measurement tuples and the associated analytes in a database to which the Control signal transmitter (8) has access, preferably to the control signal transmitter (8), wherein the storage is preferably carried out in encrypted form.