OCTYL GALATE NANOPARTICLES USED AS BREAST CANCER CELL GROWTH INHIBITORS AND THEIR PRODUCTION METHOD

Abstract

Alkyl ester derivatives of gallic acid have shown cytotoxicity against various breast cancer cells. This study aims to synthesize octyl gallate nanoparticles and evaluate their anticancer activity against MCF-7 breast cancer cells in vitro. The yield, size, and morphology of the synthesized octyl gallate nanoparticles were analyzed by UV-Vis Spectroscopy, Particle Size Analyzer (PSA), and Transmission Electron Microscopy (TEM). Octyl gallate nanoparticles were successfully synthesized with a yield of 96%, using the ionic gelation method with chitosan-alginate polymer as a nanocarrier. The characterization results showed that the octyl gallate nanoparticles were spherical in shape with sizes ranging from 100 to 200 nm, and showed high stability with a zeta potential value of -41.5 mV.Octyl gallate nanoparticles have a median inhibitory concentration (IC50) value of 3.05 µg / mL against MCF-7 breast cancer cells, which shows strong anticancer activity and has the potential to be developed as a new drug candidate for breast cancer treatment therapy.