PEPTIDE NANOSPONS FOR DRUG DELIVERY

Abstract

The present disclosure describes peptide nanosponges comprising a plurality of self-assembling peptide building blocks. The plurality of self-assembling peptide building blocks includes a first peptide building block comprising: a branched polymeric core comprising at least three arms; a first block co-peptide covalently bonded to one of said arms, wherein said first block co-peptide includes a first peptide block and a second peptide block different from the first peptide block; a lipid-based capping group covalently bonded to the first block co-peptide; and a therapeutically active compound covalently bonded via a cleavable bond to the first block co-peptide. Advantageously, said block co-peptide is covalently bonded to the core such that it is resistant to enzymatic cleavage of the core.