Trpm8 modulators
Patent Information
- Application Number
- IL293272
- Authority / Receiving Office
- IL · IL
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2019-11-29
- Filing Date
- 2020-11-26
- Publication Date
- 2026-07-01
- Estimated Expiration
- 2040-11-26
AI Technical Summary
Current TRPM8 modulators, such as menthol and its derivatives, provide short-lasting cooling sensations and are structurally similar, limiting their effectiveness and versatility in consumer products that require long-lasting and potent cooling effects.
Development of a new class of chemical compounds that significantly differ structurally from known TRPM8 modulators, capable of activating TRPM8 ion channels at very low concentrations, providing both immediate and long-lasting cooling sensations by inducing a Ca2+ influx in cold-sensitive neurons.
These compounds deliver potent and sustained cooling effects at low concentrations, enhancing the appeal and acceptability of consumer products by providing a prolonged cooling sensation, making them suitable for various applications including oral care, personal care, and food products.