Process for the production of ferroportin inhibitors
IL296653A1Pending Publication Date: 2026-07-01VIFOR (INT) AG
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Patent Information
- Application Number
- IL296653
- Authority / Receiving Office
- IL · IL
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2020-03-24
- Filing Date
- 2021-03-23
- Publication Date
- 2026-07-01
- Estimated Expiration
- 2041-03-23
AI Technical Summary
Technical Problem
Current methods for producing ferroportin inhibitors are inefficient, with high costs, low yields, and safety concerns due to multiple chromatographic steps and the formation of critical by-products, which complicates the treatment of iron overload disorders.
Method used
A new process involving the reaction of specific compounds to form ferroportin inhibitors, reducing the number of process steps, avoiding chromatographic steps, and using safer reagents, resulting in higher yields and purity.
Benefits of technology
The new process significantly improves yield and purity of ferroportin inhibitors, making them more effective and safer for use in treating iron overload disorders such as thalassemia and hemochromatosis.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to a new process for preparing compounds of the formula (I) and pharmaceutically acceptable salts thereof, which act as ferroportin inhibitors being suitable for the use as medicaments in the prophylaxis and / or treatment of diseases caused by a lack of hepcidin or of iron metabolism disorders leading to increased iron levels or increased iron absorption, including iron overload, thalassemia, sickle cell disease and hemochromatosis.
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