Pharmaceutical composition containing acetominophen and ibuprofen
Patent Information
- Application Number
- IL330596
- Authority / Receiving Office
- IL · IL
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2019-02-27
- Filing Date
- 2020-02-27
- Publication Date
- 2026-08-01
AI Technical Summary
Current pharmaceutical compositions of ibuprofen and acetaminophen do not achieve high enough maximum plasma concentrations for effective and long-lasting pain relief, particularly in fast-acting formulations, leading to suboptimal analgesia and increased remedication requirements.
Development of solid oral unit dosage forms containing ibuprofen with a particle size larger than 1,000 nm and a rapid dissolution rate, combined with acetaminophen, to achieve higher maximum plasma concentrations of ibuprofen, specifically through jet milling and the use of surfactants like sodium lauryl sulfate, resulting in enhanced pharmacokinetic parameters and pain relief.
The described compositions, Rapid Maxigesic 325 and Rapid Maxigesic 500, demonstrate significantly higher ibuprofen Cmax and faster analgesia onset, providing longer-lasting pain relief and reducing the need for additional analgesics, with improved dissolution rates and pharmacokinetic profiles compared to existing formulations like Maxigesic.