Angiotensin ii receptor antagonist and use thereof in treatment of peripherally-induced neuropathic pain
IL330625A0Pending Publication Date: 2026-08-01BEIJING TIDE PHARMACEUTICAL CO LTD
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Patent Information
- Application Number
- IL330625
- Authority / Receiving Office
- IL · IL
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-11-29
- Filing Date
- 2025-01-16
- Publication Date
- 2026-08-01
AI Technical Summary
Technical Problem
The existing drugs for treating peripheral neuropathic pain have limited efficacy and have great side effects, which cannot effectively relieve long-term pain, especially pain related to macrophages.
Method used
AT2 receptor antagonist compounds were developed to reduce the recruitment of macrophages in the pain site by inhibiting AT2 receptors, inhibiting the production of reactive oxygen/nitrogen, thereby reducing pain signaling and avoiding central side effects.
Benefits of technology
Provides more effective pain relief and reduces side effects, especially for peripheral neuropathic pain associated with macrophages, and significant analgesic effects are validated in a variety of animal models.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention relates to an angiotensin II receptor antagonist and a use thereof in the treatment of peripherally-induced neuropathic pain. In particular, the present invention provides a compound of formula (IV) or a pharmaceutically acceptable salt thereof or a stereoisomer thereof, and a use thereof in the treatment of peripherally-induced neuropathic pain.
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