Compositions comprising polymeric lipid analogs for reducing wear of implantable devices or of materials forming such devices

IL330724A0Pending Publication Date: 2026-08-01LIPOSPHERE LTD
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Patent Information

Application Number
IL330724
Authority / Receiving Office
IL · IL
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-01-18
Filing Date
2025-01-17
Publication Date
2026-08-01

AI Technical Summary

Technical Problem

Existing implantable devices, particularly those used for joint replacement, face significant wear issues due to inadequate lubrication, leading to increased friction and material degradation, which current lubricants like bovine calf serum-based solutions cannot effectively address, especially considering ethical and variability concerns.

Method used

A composition comprising lipid-polymer conjugates, specifically designed polymeric compounds with phosphocholine analogs, is used to form lipid bilayers and liposomes, which are incorporated into implantable devices to reduce wear by enhancing lubrication and wear resistance.

Benefits of technology

The composition significantly reduces wear of implantable devices by improving lubrication, making them more durable and effective in treating conditions like osteoarthritis and other synovial joint disorders, while also being suitable for assessing wear resistance in pin-on-disk systems.

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Abstract

A composition comprising a polymeric compound as described and defined in the instant specification and claims or a lipid bilayer (e.g., a liposome) formed thereby, for use in combination with an implantable device for treating a subject in need of the implantable device, and / or for use in a pin-on-disk system, for determining wear resistance of an implantable device, is provided.
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