Prodrugs of psilocin and related 4-hydroxytryptamines
Patent Information
- Application Number
- IL330784
- Authority / Receiving Office
- IL · IL
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-01-29
- Filing Date
- 2025-01-28
- Publication Date
- 2026-09-01
AI Technical Summary
Current treatments for psychiatric disorders, particularly major depressive disorder and treatment-resistant depression, lack effective novel modalities, and existing administration methods are cumbersome, unpredictable, and unsuitable for patients with swallowing difficulties or requiring non-invasive application routes.
Development of psilocin prodrugs with specific ester and acyloxymethyl derivatives, such as fumarate salts, designed for buccal, sublingual, nasal, inhalatory, and transdermal delivery, ensuring stable inactive forms until reaching the bloodstream and rapid activation in plasma, with improved synthesis methods for high yields.
The prodrugs provide predictable, fast-acting psychedelic treatments with reduced individual variability, suitable for diverse administration routes, enhancing therapeutic efficacy and patient comfort, especially for patients with swallowing issues or neurodegenerative diseases.