A radio-responsive nanogel with auxiliary photothermal enhancement and a process for preparation thereof
Patent Information
- Authority / Receiving Office
- IN · IN
- Patent Type
- Patents
- Current Assignee / Owner
- INDIAN INST OF TECH HYDERABAD
- Filing Date
- 2025-12-03
- Publication Date
- 2026-07-09
AI Technical Summary
Conventional nanogels suffer from instability in physiological environments, leading to premature drug leakage and lack of controlled drug release, especially under radiation exposure, and fail to integrate radio-sensitization, photothermal performance, and broad-spectrum antibacterial activity, particularly against radioresistant bacteria.
A radio-responsive nanogel system is developed, comprising a polymer crosslinked with trivalent metal ions, encapsulating a photothermal agent and an auxiliary enhancer, which enhances thermal response and stability, allowing controlled drug release and antibacterial action.
The nanogel demonstrates enhanced photothermal therapy and radiosensitization, effectively inactivating both common and radioresistant bacteria, with improved stability and controlled drug release, suitable for cancer and antimicrobial applications.