Collagen-Calamine formulation containing hydrolyzed collagen and omega-3 fatty acids

Abstract

This invention relates to a chemical-herbal collagen-colamine formulation containing the novel 3-COLAPLEX system, which is designed based on the simultaneous encapsulation of three active ingredients including hydrolyzed collagen, omega-3 and vitamins required by the skin in the form of oil-in-water emulsion vesicles. In this system, omega-3 is placed as a hydrophobic compound in the vesicle core, vitamins in the interfacial area and hydrolyzed collagen in the aqueous phase or outer layer and is encapsulated spontaneously during the emulsification process. This structural arrangement reduces oxidative degradation of omega-3, increases the stability of vitamins, maintains the structural integrity of hydrolyzed collagen, and increases permeability during product storage. After topical application, the encapsulated vesicles with controlled size have a more effective penetration into the epidermal and dermal layers, providing a gradual and simultaneous release of active ingredients. This synergistic phytochemical system leads to increased moisturizing efficiency, skin soothing, improved skin barrier reconstruction, increased elasticity and rejuvenation properties, and enhanced bioavailability of active ingredients compared to conventional moisturizing creams.

Description

Description of the invention Note: Items must be written only inside [ ], otherwise they will not be reviewed. Title of the invention (as stated in the declaration) Collagen-Calamine formulation containing hydrolyzed collagen and omega-3 fatty acids Technical background of the relevant invention This invention is in the field of special and semi-solid phytochemical formulations for collagen bank moisturizing creams and skin anti-aging, oil-in-water (O / W) emulsion systems, and self-encapsulation technologies of bioactive active ingredients. In particular, the present invention relates to improving the stability, efficacy and dermal absorption of sensitive active ingredients such as hydrolyzed collagen, omega-3 fatty acids in topical chemical and phytochemical formulations. Technical problem and stating the objectives of the invention In the previous patent formulations, there was no collagen bank-based formulation, but a combination of oils, gels, and vitamins were included in the formula, which did not have much power in removing wrinkles and moisturizing. However, in this herbal chemical formulation, unlike conventional creams, collagen bank moisturizing and rejuvenating creams, active ingredients such as omega-3 and hydrolyzed collagen are included separately and freely in different phases of the formulation. This leads to several technical problems, including chemical instability, severe oxidation of omega-3, structural destruction of vitamins, reduced bioavailability and penetration of hydrolyzed collagen, and ultimately, a decrease in the effectiveness of the final product. The aim of this invention is to provide a synergistic formulation and system in which the three active ingredients are encapsulated in an oil-in-water emulsion structure as an encapsulated complex, providing maximum efficacy and skin absorption while reducing chemical degradation. A description of the state of the prior art and the history of developments related to the claimed invention. In reviewing previous patents, the problem was that the color of the product (cream and gel) changed when exposed to open air, or their acidity changed, which had an undesirable effect on the pH, color, taste or smell of the products. Therefore, the use of capsules, liposomes or microparticles in this phytochemical formulation to protect the active ingredients is known, but these systems often require complex production steps, specific excipients and high costs. Also, in many existing formulations, each active ingredient is placed in the emulsion independently and without considering its hydrophilic / hydrophobic properties and molecular chain size. This approach not only leads to undesirable interactions between the active ingredients, but also limits their synergistic effectiveness. In particular, omega-3 undergoes oxidation by up to 80% under typical cosmetic formulation conditions. Providing a solution to an existing technical problem along with an accurate, sufficient, and integrated description of the invention The solution presented in this invention is the introduction of 3-COLAPLEX technology, in which hydrolyzed collagen, omega-3 and dimethicones, and available vitamins are encapsulated simultaneously and in the presence of each other during the formation of an oil-in-water emulsion, by a self-assembly mechanism in the vesicular structure of the emulsion. In this chemical technology, the placement of each active ingredient is determined based on its hydrophilic or hydrophobic nature and the size of its molecular chain; such that omega-3, as a predominantly hydrophobic compound, is located in the oily core of the vesicle, vitamin C is located in the interfacial area or protected aqueous phase, and hydrolyzed collagen or hydrolyzed collagen peptides are located in the outer layers or aqueous phase of the capsule according to their molecular weight. This spontaneous encapsulation process, without the need for additional steps, reduces the contact of sensitive materials with destructive agents, increases chemical stability and maintains their biological activity. It is a combination that includes: The 3-COLAPLEX system consists of oil-in-water emulsion vesicles, and the three active ingredients hydrolyzed collagen, omega-3 and sodium hyaluronate are encapsulated in its vesicle structure. Its ingredients include: 5% cyclomethicone as a surface tension and softener, 5% glycerin as an emollient, 1% hydroxyethyl acrylate as an emulsifier, half a percent dimethicone 350 as a repairer and shiner, 0.5% panthenol as a strong softener and skin protector, 0.3% sodium hyaluronate as a moisturizer, 0.3% cetearyl alcohol as a strong emulsifier, and hydrolyzed collagen to create a silky texture and Anti-wrinkle and 0.1% Omega 3 as an antioxidant and 1% Euxyl PE9010 as a strong preservative and 0.5% essential oil and 0.1% SEED OIL vegetable oils and the remaining percentage of 100% deionized water. The process of preparing the collagen formulation of Calamine Bank: This formulation is made in a steel or laboratory reactor (unbreakable glass made of Perix) at a speed of 450 rpm by gradually adding cyclomethicone and glycerin hydroxyethyl acrylate dimethicone 350 and panthenol and sodium hyaluronate to deionized water and heating to 75 degrees Celsius at a pressure of 2 atmospheres (Bar) for one hour, then reducing the temperature to 60 degrees Celsius and gradually adding cetearyl alcohol into the stable aqueous paste for one hour, then reducing the temperature to 55 degrees Celsius and reducing the atmospheric pressure of the reactor from 2 to 1.5 bar, and then adding the remaining components, including hydrolyzed collagen, omega-3, Euxyl PE9010, essential oils and vegetable oils. Explanation of shapes, maps and diagrams Figure 1 - Schematic view of an oil-in-water emulsion vesicle in which omega-3 is located in the hydrophobic core, dimethicone silicone in the interfacial region, and hydrolyzed collagen in the aqueous phase or outer layer. Figure 2 - Shows a comparison of the degradation rate of omega-3 and vitamins in free and encapsulated form in a phytochemical formulation. Figure 3- Shows the dermal absorption pathway and penetration of encapsulated vesicles into the epidermis and dermis compared to conventional cream formulations. A clear and precise statement of the advantages of the claimed invention over prior inventions. The advantages of this invention include: – Significant reduction in oxidation and degradation of omega-3 – Increase the stability and effectiveness of vitamin C and hydrolyzed collagen – Creating a real synergistic effect between the three active ingredients – More effective skin absorption due to controlled particle size and vesicular structure – Higher efficiency than using individual active ingredients in conventional creams – No need for complex and costly encapsulation technologies Description of at least one implementation method for implementing the invention This invention is a herbal chemical formulation and if converted into a topical emulsion, it should be applied three times during the day and night on clean skin of the hands and face (which has been previously washed and dried) (it is better not to wash the skin from night to morning after applying Calamine Collagen). It is recommended that the product container be stored in the refrigerator and not under sunlight. After consumption, the anti-wrinkle process of the skin is gradually activated. The oil phase and the water phase of the Collagen Bank moisturizing cream are completely homogenized and the active ingredients of hydrolyzed collagen, omega-3 and vitamins are simultaneously absorbed into the skin and the encapsulation that has occurred shows itself in the final cream with a stable and uniform structure and smooth and soft skin is achieved over time and the active ingredients are gradually and effectively absorbed by the skin. Explicit mention of the industrial application of the invention This invention and herbal chemical formulation has the capability of industrial production in conventional production lines for the production of cosmetic-hygienic creams in 316 and 316L steel reactors and can be used in the industries of producing moisturizing, anti-aging, restorative, and skin care products.

Claims

Claims What is claimed: Claim 1) The collagen formulation of the Bank of Calamine with chemical and herbal moisturizing capabilities includes the 3-COLAPLEX system consisting of oil-in-water emulsion vesicles, and the three active ingredients hydrolyzed collagen, omega-3, and sodium hyaluronate are encapsulated in its vesicular structure, whose ingredients include: 5% cyclomethicone as a surface tension and softener, 5% glycerin as an emollient, 1% hydroxyethyl acrylate as an emulsifier, half a percent dimethicone 350 as a repairer and shiner, 0.5% panthenol as a strong softener and skin protector, 0.3% sodium hyaluronate as a moisturizer, 0.3% cetearyl alcohol as a strong emulsifier, and hydrolyzed collagen to create a silky and anti-wrinkle texture, 0.1% omega-3 as an antioxidant, and 1% Euxyl PE9010 is a strong preservative, 0.5% essential oil, 0.1% SEED OIL vegetable oils, and the rest of the formula is deionized water. Claim 2) According to claim 1, omega-3 is placed in the hydrophobic core of the vesicle, sodium hyaluronate in the interfacial region, and hydrolyzed collagen in the aqueous phase or outer layer of the vesicle. Claim 3) According to claim 1, wherein cyclomethicone is present at a concentration of 5% by weight and is an emulsifier that causes surface tension and softens the skin, and this formulation is formed spontaneously and simultaneously with the emulsification process, leading to stable encapsulation of the active ingredients without the need for separate encapsulation steps. Claim 4) According to claim 1, in addition to the active ingredients mentioned, it contains half a percent dimethicone 350 as a repairer and brightener and 0.5 percent panthenol as a strong softener and skin protector, so that the final product is chemically capable of vesicular encapsulation and reduces oxidative degradation of omega-3 and increases collagen stability during product storage. Claim 5) According to claim 1, in this useful chemical formulation, 1% hydroxyethyl acrylate is present as a useful emulsifier and is uniformly distributed in the chemical matrix of the product, and this system provides gradual and simultaneous release of active ingredients in the epidermis and dermis layers of the skin after topical application. Claim 6) According to claim 1, the collagen bank calamine formulation through the 3-COLAPLEX synergistic system increases bioefficacy, long-lasting moisturizing, and skin soothing compared to conventional formulations because the size of the encapsulated vesicles is adjusted to improve skin absorption and controlled penetration of the active ingredients. Claim 7) The process of preparing the collagen bank calamine formulation includes: This formulation is made in a steel or laboratory reactor (unbreakable glass made of Perix) at a speed of 450 rpm by gradually adding cyclomethicone and glycerin hydroxyethyl acrylate dimethicone 350 and panthenol and sodium hyaluronate to deionized water and heating to a temperature of 75 degrees Celsius at a pressure of 2 atmospheres (Bar) for one hour and then reducing the temperature to 60 degrees Celsius and gradually adding cetearyl alcohol inside the stable water paste for one hour and then reducing the temperature to 55 degrees Celsius and reducing the atmospheric pressure of the reactor from 2 to 1.5 bar and then adding the remaining components including hydrolyzed collagen and omega 3 and Euxyl PE9010 and essential oils and vegetable oils.

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