Nutraceutical formulation based on camel milk

Description

DESCRIPTION Scope of application The present invention relates to the technical sector of industry nutraceuticals of food supplements. 5 In particular, the invention relates to a formulation nutraceutical or a food supplement, based on camel milk. Known art It is known that camel milk is a particularly hypoallergenic as it does not contain beta-casein and other important 10 allergens, such as a reduced lactose content. In fact, milk camel is highly recommended for those who suffer from intolerance to lactose, an intolerance that is increasingly affecting the world's population. It is also known to have an anti-diabetic action as it contains a insulin-like protein that is absorbed without being degraded 15 from digestive enzymes as it is encapsulated by nanoparticles. Numerous scientific researches have highlighted the ability camel milk to improve blood sugar levels and reduce the need for insulin even in the long term in patients with diabetes mellitus of both type 1 than type 2, also improving the lipid profile, oxidative stress 20 and renal and hepatic function. The hypoglycemic activity is due to an action of insulin-like substances, present in high concentration in said milk, which are able to resist the degradation in the acidic environment of the stomach and the combined action of the other active components of camel milk that act in various ways 25 levels of the metabolic picture of the disease. Camel milk contains compounds that appear to fight various pathogenic organisms. The two main active components of the camel milk are lactoferrin and immunoglobulins, proteins that can give camel milk its immunostimulating properties. 5 Lactoferrin has antibacterial, antifungal properties, antiviral, antiparasitic, anti-inflammatory. In fact, it inhibits growth of E. coli, K. pneumoniae, Clostridium, H. pylori, S. aureus, et C. albicans, organisms that can cause serious infections. The immunostimulatory properties have been confirmed by one 10 studies on laboratory animals in which it was found that milk camel protects against leukopenia and some side effects due to anticancer drugs, such as cyclophosphamide. Furthermore, it is known that lactoferrin, one of the main components of camel milk, appears to have an action in blocking or inhibiting the 15 proliferation of tumor cells. In fact, there are studies that attest in vitro cellular inhibition of colon cancer cells and of hepatocellular carcinoma by camel milk. Consequently, the Camel milk may aid antitumor activity in therapies tumors (1-2). 20 Furthermore, camel milk may have antioxidant properties which help the body fight damage from free radicals. Camel milk can be integrated into the diets of those who are suffering from neurological diseases, such as Alzheimer's, Parkinson's or autism, which have oxidative stress among their causes. Nutrition seems to 25 have more and more responsibility in the symptoms and the course of a disease, particularly in neurological diseases, such as autism in which studies have been carried out on ketogenic, gluten-free and gluten-free diets casein (3). Consequently, camel milk could be a food that brings nutritional benefits (4-5). 5 Furthermore, camel milk being low in fat, can be a natural solution or dietary supplement for fatty liver disease non-alcoholic fatty liver disease (NAFLD) induced by a high-fat diet (6), several dyslipidemia, as it can control the level of cholesterol and other lipids circulating (7-8). 10 Furthermore, when camel milk is fermented with probiotics, such as Lactobacillus helveticus and Lactobacillus rhamnosus, may contain bioactive peptides similar to the ACE inhibitors present in camel milk fermented with probiotics, which may have a role in the treatment of hypertension (9-10). 15 The concentration of active ingredients in camel milk can be different depending on the variety of the product and on how it was made treaty. In addition, the preservation of camel milk is also important: exposure to air, light or unsuitable temperatures could lead to a reduction in assets. 20 Although camel milk has undoubted benefits beneficial characteristics as indicated above, is felt in the sector the need to make available a formulation based on milk camel that provides greater nutritional and / or therapeutic benefits compared to the simple oral administration of camel milk 25 through normal power supply. The technical problem underlying this invention is therefore that of making available an oral formulation based on camel milk that satisfies the above requirement. Summary of the invention 5 This problem has been solved by a nutraceutical formulation oral containing camel milk and at least one complement nutritional. In one embodiment, the amount of camel milk in the formulation is between 0.1 and 99.9% by weight on the weight of the 10 nutraceutical formulation, preferably between 10% and 90%. In one embodiment, the amount of the at least one nutritional supplement is between 1% and 50%, preferably between 1 and 20% by weight of the formulation weight. Detailed description 15 In the present invention, the percentage amounts indicated are reported on the overall weight of the formulation, including of any liquid (water) coming for example from milk camel as in the case of a liquid formulation. For the purposes of this invention, the expression “milk” 20 “camel” means milk derived from raw camel milk and / or dromedary, in particular camelids of the species Camelus dromedarius – possible breeds: Mewari, Bikaneri, Kachchi and Jaisalmeri, subjected to after physical or chemical treatment in accordance with Article 4 of the Regulation (EU) No. 605 / 2010 (11-15). In the wording according to 25 the invention, camel milk can be present in liquid form after the above treatment or in dried form (e.g. powdered milk) in case of a solid formulation. In the present invention with the expression “nutraceutical formulation” means any formulation that serves 5 to supplement the body with micronutrients, such as salts and vitamins, in case of a deficiency, such as supplements or formulations which are able to prevent some diseases and which have an effect therapeutic. The nutraceutical formulation of the invention is in any 10 solid or liquid form suitable for administration or intake oral, in particular powder, lozenge, chewable tablet, capsule, drink, solution, syrup or suspension. In one embodiment of the invention, the formulation nutraceuticals include at least one nutritional supplement 15 vitamin chosen from one or more B vitamins, in particular Vitamin B12 or riboflavin, Vitamin A, Vitamin C or mixtures of these. In one embodiment of the invention, the formulation nutraceuticals includes as an additional nutritional supplement or alternative to the vitamins listed above at least one glycoprotein 20 synthetically produced corresponding to the intrinsic factor or glycoprotein produced by the parietal cells lining the wall of the stomach essential for the absorption of vitamin B12. In one embodiment, the nutraceutical formulation includes as an additional or alternative nutritional supplement to 25 vitamins and / or the glycoprotein mentioned above at least one substance nootropic and / or a plant or plant seed extract containing at least a nootropic substance. Nootropic substances can be chosen from inositol, hypericin, hyperforin, theanine, theophylline, acetyl-L-Carnitine, chromium, 5 coenzyme Q 10, creatine, lipoic acid, pyritinol, vinpocetine, norvaline, caffeine, scopolamine, idebenone, choline alfoscerate, flavonoids, such as luteolin, quercetin, apigenin or kaempferol, rosmarinic acid, diterpenes and triterpenes, alkaloids such as withanin, withaninine, witasomnine, coumarins, flavonoid polysaccharides such as eleutherans, 10 eleutherosides A to M, selegiline, or mixtures thereof. The above mentioned nootropic substances can be derived from synthesis chemical or be contained in the formulation in the form of extracts containing one or more of the said substances. Such extracts may be obtained by extraction in water or hydroalcoholic solvent from plants 15 vegetables or plant seeds such as Ashwagandha, lemon balm, rhodiola rosea, hypericum perforatum, Siberian ginseng, sutherlandia frutescens, tea, coffee, bacopa monnieri, ginco biloba, mate, etc. The formulation may further comprise an agent flavoring and / or a sweetening agent and / or an emulsifying agent. 20 Advantageously said formulation or supplement provides greater nutritional benefits than simply drinking milk of camel, in fact, providing a more complete nutritional intake thanks to the presence of the nutritional supplement that can be chosen according to the needs. Furthermore, the formulation according to the invention can 25 also provide therapeutic benefits where the nutritional supplement It also has a therapeutic effect as in the case of substances nootropics. In fact, with an appropriate choice of at least one complement nutritional the formulation according to the invention allows to maintain 5 under control of high blood sugar levels. In particular, this formulation helps regulate cardiovascular function, promotes the carbohydrate metabolism, has an antioxidant activity and promotes digestive function. Advantageously, the formulation according to this 10 invention also allows to reduce oxidative stress and improve the functionality of the arterial wall by administering anti-oxidative drugs. Furthermore, advantageously, this formulation nutraceutical, being administered orally and being readily available 15 assumption, it is easy to handle for a user, since it does not need be stored under particular conditions and can be taken in any time of the day without prior preparation. The advantages and characteristics of cosmetic composition according to the present invention will be clearer from the 20 detailed description and the following examples given for indicative purposes only and not limiting. EXAMPLES Example 1 (dry formulation) A nutraceutical powder formulation has been prepared 25 having the following quantities reported as a percentage by weight of the weight of the formulation. Example 1 Camel milk powder 70% Intrinsic Factor (Glycoprotein) 4% Choline Alfoscerate 4% Ashwagandha Extract 4% Rhodiola Rosea Extract 4% Ginkgo Biloba Extract 4% Bacopa Monnieri Extract 4% Mate extract 3% Proline 1% Glycine 1% Flavoring Agent 1% Total 100 The powdered ingredients listed above have been mixed until with homogeneity and with the mixture obtained formulations were produced 5 nutraceuticals according to the present invention for administration Oral. Example 2 (liquid formulation) A liquid nutraceutical formulation has been prepared having the following quantities reported as a percentage by weight of the weight of the 10 formulation. Raw camel milk 80% Intrinsic Factor (Glycoprotein) 3% Choline Alfoscerate 3% Ashwagandha Extract 3% Rhodiola Rosea Extract 3% Ginkgo Biloba Extract 3% Bacopa Monnieri Extract 3% Mate extract 1% Flavoring Agent 1% Total 100 The above listed powdered ingredients have been added to the camel milk stirred until homogeneous, obtaining a liquid nutraceutical formulation that can be taken as a drink. Reference bibliography 1. Dubey US, Lal M, Mittal A, Kapur S. Therapeutic potential of camel milk. Emirates J. Food and Agriculture. 2016;28:164-176. 2. Krishnankutty R, Iskandarani A, Therachiyil L, Uddin S, Azizi F, 5 Kulinski M, Bhat AA, Mohammad RM. Anticancer Activity of Camel Milk via Induction of Autophagic Death in Human Colorectal and Breast Cancer Cells Asian Pac J Cancer Prev. 2018;19:3501-9. 3. Cekici H, Sanlier N Current nutritional approaches in management autism spectrum disorder: A review Nutr Neurosci. 2019;22:145-155. 10 4. Al-Ayadhi LY, Elamin NE. Camel Milk as a Potential Therapy as an Antioxidant in Autism Spectrum Disorder (ASD). Evid Based Complement Alternat Med. 2013;ID602834 5. Al-Ayadhi LY, Halepoto DM, Al-Dress AM, Mitwali Y, Zainah R Behavioral Benefits of Camel Milk in Subjects with Autism Spectrum 15 Disorder.J Coll Physicians Surg Pak. 2015;25:819-23. 6. Korish AA, Arafah MM. Camel milk ameliorates steatohepatitis, insulin resistance and lipid peroxidation in experimental non-alcholic fatty liver disease. Complementary and Alternative Medicine 2013; 13:264-278. 20 7. Korish AA. The antidiabetic action of camel milk in experimental type 2 diabetes mellitus: an overview on the changes in incretin hormones, insulin resistance and inflammatory cytokines. Horm metab res 2014; 46 : 404-11 8. El-Shinnawy NA, Abd Elhalem SS, Haggag NZ, Badr G. 25 Ameliorative role of camel whey protein and rosuvastatin on induced dyslipidemia in mice. Food Funct. 2018;9:1038-1047. 9. Yahya MA, Alhaj OA, Al-Khalifah AS. Antihypertensive effect of fermented skim camel (Camelus dromedarius) milk on spontaneously hypertensive rats. Nutr Hosp. 2017;34:416-421. 5 10. Forsgård RA, Lactose digestion in humans: intestinal lactase appears to be constitutive whereas the colonic microbiome is adaptable Am J Clin Nutr. 2019;110:273-279. 11. FAO, FAOSTAT, Food and Agriculture Organization of the United Nations, 2017. [Online]. Available: 10 http: / / www.fao.org / faostat / en / #home. 12. Omar A, Abdurahman Sh. Milk and Meat from the Camel: Handbook on Products and Processing. Z. Farah and Z. Fischer (Eds.), Swiss Federal Institute of Technology, Zurich, 2004. Cap.1.2 13. Alhadrami GA, Faye B. Animal that produce dairy food: camel, 15 Elsevier Reference Module in Food Science, Elsevier / Academic Press 2016, Pag,1-12 14. A. Sakandar, S. Ahmad, R. Perveen, HKW Aslam, A. Shakeel, FA Sadiq, M. Imran. Camel milk and its allied health claims: a review. Progress in Nutrition 2018; Flight. 20, Suppl 1: 15-29 20 15. Miniero R, Mazza GA, Pasqua A, Dolceamore TR, Zurlo F, Mahadi AM, Britti D. Composition and therapeutic potentials of camel milk. Large Animal Review 2014; 20:125-132.

Claims

1. Oral nutraceutical formulation comprising camel milk and at least one nutritional supplement.

2. Nutraceutical formulation according to claim 1, wherein the amount of camel milk in the formulation is between 0.1% and 99.9% by weight of the nutraceutical formulation, preferably between 10% and 90%.

3. Nutraceutical formulation according to claim 1 or 2, wherein the amount of each nutritional supplement is between 1% and 50%, preferably between 1 and 20% by weight of the weight of the formulation.

4. Nutraceutical formulation according to any of the preceding claims, comprising as a nutritional supplement at least one vitamin selected from one or more B vitamins, in particular Vitamin B12 or riboflavin, Vitamin A, Vitamin C or mixtures thereof.

5. Nutraceutical formulation according to any of the preceding claims, comprising as a nutritional supplement at least one synthetically produced glycoprotein corresponding to the intrinsic factor or glycoprotein produced by the parietal cells lining the stomach wall and essential for the absorption of vitamin B12.

6. Nutraceutical formulation according to any of the preceding claims, comprising as a nutritional supplement at least one nootropic substance selected from inositol, hypericin, hyperforin, SRN001BIT Dr. Umberto Zambardino (Registration no. 862 B) theanine, theophylline, acetyl-L-Carnitine, chromium, coenzyme Q 10, creatine, lipoic acid, pyritinol, vinpocetine, norvaline, caffeine, scopolamine, idebenone, choline alfoscerate, flavonoids, such as luteolin, quercetin, apigenin or kaempferol, rosmarinic acid, diterpenes and triterpenes, 5 alkaloids such as withanine, withananine, withasomnine, coumarins, polysaccharides such as eleutherans, eleutherosides from A to M, selegiline, or mixtures thereof.

7. Nutraceutical formulation according to claim 6, comprising at least one extract from a plant or plant seed 10 containing said at least one nootropic substance.

8. Nutraceutical formulation according to any of the preceding claims, wherein said nutraceutical formulation is in a liquid or solid oral form chosen from powder, lozenge, chewable tablet, capsule, solution, syrup, suspension or beverage.