Packed liquid composition

Abstract

To provide a packed liquid composition which is, when applied particularly to a skin surface, excellent in disinfection and or virus destroying activity and a prolonged effect of the same.SOLUTION: A packed liquid composition is provided which is obtained by housing a liquid composition in a container, wherein the liquid composition contains a component (A): one or more polyols satisfying logPow value≥-0.3; and a component (B): a disinfectant other than alcohol-based ones, and wherein a content of the component (A) is 0.05 mass% to 30 mass% and a content of the (B) component is 0.01 mass% to 10 mass%, a content of glyceryl trioctanoate is less than 2 mass%, and the pH of the liquid composition at 25°C is 3.5 to 7.0.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a packaged liquid composition, and more particularly to a packaged liquid composition suitable for use as a bactericidal and / or virucidal external preparation for skin application. [Background technology]

[0002] Recent studies have shown that contact infection is a common route of bacterial or viral infection in people's daily lives. Contact infection occurs primarily when hands come into contact with infected people, doorknobs, handles, tableware, toys, other household items, interior decorations, and other objects.

[0003] There is a need for a method to prevent bacterial or viral infections caused by contact in such everyday life. As a method for preventing contact infection of bacteria or viruses via hands, a method of applying an alcohol-based disinfectant to hands to sterilize and disinfect them is known. However, alcohols such as ethanol used as sterilizing or disinfecting components are highly volatile, and the effect is not sufficiently sustained in terms of imparting a sterilizing or virucidal effect to hands.

[0004] Therefore, methods for providing hands with a defense function against bacteria or viruses have been studied. These methods continuously provide a bacterial or viral infection prevention effect, making it possible to prevent contact infection even in environments where there is no hand-washing facility, such as when out and about. This is particularly preferable because it can prevent infection even when repeatedly coming into contact with an object that has bacteria or viruses attached.

[0005] For example, Patent Document 1 discloses a method for inhibiting bacteria and viruses present on the skin surface of a mammal, which comprises contacting the skin for at least about 0.5 hours with a compound or composition capable of reducing the skin pH to less than about 4. It also discloses that the compound or composition capable of reducing the skin pH further contains an antimicrobial agent selected from the group consisting of phenolic antibacterial agents, quaternary ammonium antimicrobial agents, anilides, bisguanidines, and mixtures thereof.

[0006] Additionally, compositions for sterilizing the skin that contain a bactericide or antibacterial agent are known (for example, Patent Document 2). Patent Document 2 discloses that a long-lasting antiseptic cream for disinfection contains a cationic antiseptic, a lower alcohol, an oily base, a higher aliphatic alcohol, a lipophilic and hydrophilic nonionic surfactant, a water-soluble polyhydric alcohol, and purified water, and has a long-lasting disinfecting effect on the skin, hands, and traumatic wounds, as well as an effect of preventing rough hands. [Prior art documents] [Patent documents]

[0007] [Patent Document 1] Special Publication No. 2008-523064 [Patent Document 2] Japanese Patent Application Laid-Open No. 2007-284412 Summary of the Invention [Problem to be solved by the invention]

[0008] Cationic disinfectants such as benzalkonium chloride are commonly used in disinfectants for skin applications such as hand disinfectants. However, the inventors' studies have revealed that, compared to inorganic materials such as stainless steel and glass, it is difficult to achieve a bactericidal effect on the surface of human skin using non-alcohol-based disinfectants, such as cationic disinfectants. Furthermore, the amount of disinfectants and antibacterial agents that can be incorporated into skin compositions may be substantially limited due to factors such as safety for the human body. Therefore, the bactericidal and virucidal activity and sustained effect of the disinfectants or antibacterial agents on the skin are insufficient, and further improvements are desired. Furthermore, in Patent Document 2, a bactericidal disinfectant is applied to undisinfected hands after hand washing, and the reduction rate of the number of bacteria after disinfection relative to the number of bacteria before disinfection is evaluated. However, no study was conducted on whether a bactericidal / viricidal effect can be sustained when bacteria or viruses are subsequently attached to hands by providing the hands with a defense function against bacteria or viruses in advance, and in this respect there is room for improvement.

[0009] The present invention relates to a packaged liquid composition that has excellent bactericidal and / or virucidal activity and that has a sustained effect, particularly when applied to the skin surface. [Means for solving the problem]

[0010] The present inventors have found that a containerized liquid composition containing a liquid composition that contains a predetermined amount of a polyol and a bactericide that satisfy predetermined requirements, has a content of a specific oily component that is not more than a predetermined amount, and has a pH within a predetermined range, has excellent bactericidal and / or virucidal activity and its sustained effect.

[0011] That is, the present invention relates to the following. [1] Component (A): logP ow one or more polyols satisfying a value of ≧−0.3, and Ingredient (B): Non-alcohol-based disinfectant, Contains The content of the component (A) is 0.05% by mass or more and 30% by mass or less, The content of the component (B) is 0.01% by mass or more and 10% by mass or less, A containerized liquid composition containing a liquid composition having a glycerin trioctanoate content of less than 2% by mass and a pH of 3.5 or more and 7.0 or less at 25°C, the liquid composition being contained in a container. [2] A method for protecting skin from bacteria or viruses using the container-packed liquid composition described in [1] above, comprising the step of applying the liquid composition contained in a container to the skin. [3] Use of a polyol (A) having a log Pow value of ≧-0.3 to enhance or sustain the bactericidal effect on the skin of a non-alcohol-based bactericide (B). [Effects of the Invention]

[0012] According to the present invention, it is possible to provide a packaged liquid composition that has excellent bactericidal and / or virucidal activity and a sustained effect, particularly when applied to the skin surface. The packaged liquid composition is useful as a packaged liquid composition for external use on the skin for bactericidal and / or virucidal purposes. DETAILED DESCRIPTION OF THE INVENTION

[0013] [Containerized liquid composition] The packaged liquid composition of the present invention comprises: Component (A):logP ow one or more polyols satisfying a value of ≧−0.3, and Ingredient (B): Non-alcohol-based disinfectant, The liquid composition contains a component (A) content of 0.05% by mass or more and 30% by mass or less, a component (B) content of 0.01% by mass or more and 10% by mass or less, a glycerol trioctanoate content of less than 2% by mass, and a pH of 3.5 to 7.0 at 25° C., and is contained in a container. Hereinafter, the containerized liquid composition of the present invention will also be referred to as the "liquid composition of the present invention," and the liquid composition that is the content of the container will also be referred to as the "liquid composition used in the present invention." The containerized liquid composition of the present invention has the above-mentioned constitution, and when the containerized liquid composition is applied to the skin surface in particular, it has excellent bactericidal and / or virucidal activity and its sustained effect. Note that, in the present invention, the alcohol-based disinfectant refers to a monoalcohol having 4 or less carbon atoms, such as ethanol or isopropanol. The containerized liquid composition of the present invention is a liquid composition contained in a container, and therefore, volatilization of component (A) during storage can be suppressed. Examples of such containers include spray-type, pump-type, and squeeze-type pressure-type containers.

[0014] The reason why the packaged liquid composition of the present invention exhibits bactericidal and / or virucidal activity and its sustained effect is not clear, but is thought to be as follows. As described above, the present inventors have found that it is difficult to obtain a bactericidal effect on the surface of human skin using disinfectants other than alcohol-based disinfectants. This is presumably due to the interaction between the disinfectant and the skin. Examples of non-alcohol-based disinfectants include one or more selected from the group consisting of cationic disinfectants, iodine-based disinfectants, phenol-based disinfectants, biguanide-based disinfectants, terpenoid-based disinfectants, chlorine-based disinfectants, and amphoteric surfactant-based disinfectants. Among these, when cationic disinfectants such as benzalkonium chloride or amphoteric surfactant-based disinfectants are applied, the positive charge of the disinfectant is captured by the negative charge of the skin, resulting in adsorption to the skin and a reduction in the bactericidal and / or virucidal activity of the disinfectant. In the case of iodine-based disinfectants and chlorine-based disinfectants, they are inactivated in the presence of organic matter, which is thought to reduce their bactericidal and / or virucidal activity on the skin surface. Furthermore, phenol-based disinfectants and terpenoid-based disinfectants are thought to reduce their bactericidal and / or virucidal activity due to their adsorption to the skin through hydrophobic interactions.

[0015] Therefore, the present inventors focused on polyols as a component that can effectively exert bactericidal and / or virucidal activity even on the skin surface. The polyol component (A) has an octanol / water partition coefficient, logP owIt is a polyol that satisfies a value of ≥ -0.3. Component (A) has a hydrophilic hydroxy group and a hydrophobic portion containing a C atom. The hydrophilic portion has a high affinity for water molecules and forms an interaction with them. Meanwhile, the hydrophobic portion distorts or destroys the three-dimensional hydrogen bond network of water, which has the same effect as ethanol. This distortion or destruction of the three-dimensional hydrogen bond network of water changes the water environment around bacteria and viruses. This change is thought to have the effect of denaturing, for example, hydrophilic membrane proteins. where logP ow The higher the value, the higher the hydrophobicity. Component (A) has a certain level of hydrophobicity or higher, and it is thought that it is easy to obtain the effect of distorting or destroying the three-dimensional hydrogen bond network of water. Furthermore, component (A) is less volatile than the alcohol-based disinfectant, and can remain near the skin surface at a high concentration for a long time even after application of a liquid composition containing component (A) to the skin. Therefore, it is believed that the bactericidal and / or virucidal activity is also excellent in durability. Furthermore, component (A) also acts as a solvent for component (B) on the skin surface, suppressing the adsorption of component (B) to the skin surface, which is thought to have the effect of suppressing a decrease in the bactericidal and / or virucidal activity of component (B). Due to the above-mentioned mechanism of action, it is believed that by using the packaged liquid composition of the present invention, component (A) itself exhibits bactericidal and / or virucidal activity, while suppressing the decline in the bactericidal and / or virucidal activity of component (B), and that a synergistic effect of bactericidal and / or virucidal activity can be obtained by using component (A) and component (B) in combination.

[0016] Furthermore, it is believed that the liquid composition used in the present invention has a pH of 3.5 or more and 7.0 or less at 25°C, which makes it possible to suppress skin irritation while improving the bactericidal and / or virucidal activity and its sustained effect. Furthermore, the liquid composition used in the present invention contains less than 2% by mass of glycerin trioctanoate. When glycerin trioctanoate is blended in at 2% by mass or more, it inhibits contact between components (A) and (B) and bacteria and / or viruses, reducing the bactericidal effect. This is thought to be because glycerin trioctanoate forms an oil film on the skin, which coats components (A) and (B), making it difficult for them to act on bacteria. On the other hand, by making the content of glycerin trioctanoate in the liquid composition used in the present invention less than 2% by mass, bactericidal and / or virucidal activity and its sustained effect can be obtained. From the viewpoint of obtaining bactericidal and / or virucidal activity and its sustained effect, the content of glycerol trioctanoate is preferably 1.9% by mass or less, more preferably 1.8% by mass or less, even more preferably 1.5% by mass or less, still more preferably 1% by mass or less, even more preferably 0.5% by mass or less, even more preferably 0.2% by mass or less, still more preferably 0.1% by mass or less, still more preferably 0.05% by mass or less, and may be essentially 0% by mass. Furthermore, from the viewpoint of obtaining bactericidal and / or virucidal activity and its sustained effect, the liquid composition used in the present invention preferably contains less than 2.0% by mass of triglycerides whose constituent fatty acids are saturated fatty acids having 8 or more carbon atoms, more preferably 1.9% by mass or less, even more preferably 1.8% by mass or less, and even more preferably 1.5% by mass or less. Furthermore, from the viewpoint of obtaining bactericidal and / or virucidal activity and its sustained effect, the liquid composition used in the present invention preferably has a triglyceride content of less than 2.0% by mass, more preferably 1.9% by mass or less, even more preferably 1.8% by mass or less, and particularly preferably 1.5% by mass or less. The content of the triglyceride containing only saturated fatty acids having 8 or more carbon atoms as constituent fatty acids and the content of the triglyceride also include the content of glyceryl trioctanoate.

[0017] The liquid composition used in the present invention preferably has a low oily component content, from the viewpoint of not inhibiting contact of components (A) and (B) with bacteria and / or viruses and obtaining bactericidal and / or virucidal activity and its sustained effect. In the present invention, the oily component refers to an oil agent having a solubility of less than 0.01 g in 100 g of water at 20°C, and examples thereof include silicone oil, ester oil, ether oil, hydrocarbon oil, fatty acid having 12 or more carbon atoms, and higher alcohol having 12 or more carbon atoms. From the viewpoint of obtaining bactericidal and / or virucidal activity and its sustained effect, the content of the oily component in the liquid composition used in the present invention is preferably 5% by mass or less, more preferably 4.5% by mass or less, more preferably 3% by mass or less, even more preferably less than 2% by mass, still more preferably 1.9% by mass or less, even more preferably 1.8% by mass or less, still more preferably 1.5% by mass or less, still more preferably 1% by mass or less, still more preferably 0.5% by mass or less, even more preferably 0.2% by mass or less, still more preferably 0.1% by mass or less, still more preferably 0.05% by mass or less, and may be essentially 0% by mass. The content of the oily component includes the content of glycerin trioctanoate.

[0018] The object to be sterilized and / or killed by the packaged liquid composition of the present invention is not particularly limited, but from the viewpoint of the high usefulness of the present invention, it is preferably skin, more preferably skin excluding the scalp. The liquid composition contained in the container used in the present invention is more preferably a leave-on topical skin composition. As used herein, the term "leave-on topical skin composition" refers to a topical skin composition that is used after application to the skin without being removed by rinsing with water or the like. The liquid composition used in the present invention can impart a bactericidal and / or virucidal effect to the skin surface by leaving the bactericidal and / or virucidal components, component (A) and component (B), on the skin surface. From the viewpoint of obtaining this effect, it is preferable that the liquid composition used in the present invention is used by leaving the composition on the skin surface after application by coating or the like, without removing the composition by rinsing with water or the like. From the viewpoint of preventing contact infection with bacteria or viruses, the liquid composition used in the present invention is more preferably a leave-on skin external preparation composition for use on the hands and fingers.

[0019] As used herein, "bactericidal and / or virucidal activity" refers to the bactericidal and / or virucidal activity possessed by the packaged liquid composition of the present invention and the liquid composition itself used therein. For example, the bactericidal activity against Serratia marcescens can be specifically evaluated by the method described in the Examples. The activity against other bacteria and viruses can be evaluated taking into account common technical knowledge.

[0020] The bacteria or viruses against which the packaged liquid composition of the present invention exerts bactericidal and / or virucidal activity are not particularly limited, as long as they are inactivated or killed by contact with the liquid composition used in the present invention. For example, it is considered that the microorganisms listed in the Ministry of Health, Labor and Welfare's guidelines for infectious disease control in nurseries can be applied. Specific examples of bacteria include gram-positive bacteria such as Bacillus anthracis, Mycobacterium tuberculosis, hemolytic streptococcus, Staphylococcus aureus, and Streptococcus pneumoniae, as well as gram-negative bacteria such as Francisella tularensis, Yersinia pestis, Brucella, Bacillus mallei, Vibrio cholerae, Salmonella enterica, Shigella, enterohemorrhagic Escherichia coli, and Bordetella pertussis. Examples of viruses include enveloped viruses such as arenaviruses, Ebola viruses, smallpox viruses, nairoviruses, Marburg viruses, coronaviruses, monkeypox viruses, betacoronaviruses, influenza viruses, respiratory syncytial viruses, herpes viruses, mumps viruses, varicella-zoster viruses, rubella viruses, and measles viruses, as well as non-enveloped viruses such as enteroviruses, adenoviruses, coxsackieviruses, noroviruses, and rotaviruses. In this example, the bactericidal activity is evaluated using Serratia marcescens as an example, but the bacteria or viruses targeted by the present invention are not limited to this.

[0021] <Component (A): Polyol> The component (A) used in the liquid composition has a logP owA polyol that satisfies the value of ≧−0.3. Component (A) itself acts as a bactericidal and / or virucidal component, and, due to the above-mentioned mechanism of action, can suppress a decrease in the bactericidal and / or virucidal activity of component (B).

[0022] Log P of component (A) ow From the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect, the logP value is -0.3 or more, preferably 0.0 or more, more preferably 0.2 or more, and even more preferably 0.5 or more. ow This is because it is believed that the larger the value, the more hydrophobic the component (A) is, and the more likely it is to have the effect of distorting or destroying the three-dimensional hydrogen bond network of water. On the other hand, from the viewpoint of preventing percutaneous absorption of component (A) when the liquid composition is applied to the skin and enhancing the sustained effect of bactericidal and / or virucidal activity, it is also desirable to ow The value is preferably 2.0 or less, more preferably 1.0 or less, and even more preferably 0.7 or less. And the logP of component (A) ow The value is −0.3 or more, preferably 0.0 or more and 2.0 or less, more preferably 0.2 or more and 2.0 or less, even more preferably 0.2 or more and 1.0 or less, and even more preferably 0.5 or more and 0.7 or less. where: P ow : The concentration ratio of component (A) in the two solvent phases of 1-octanol and water when component (A) is added to the two solvent phases and reaches equilibrium. logP ow =log 10 (Concentration of component (A) in 1-octanol phase / Concentration of component (A) in aqueous phase) is. Log P of component (A) ow The value can be calculated using the algorithm "XLOGP3" described in Renxiao Wang et al., J. Chem. Inf. Model. 2007, Vol. 47, pp. 2140.

[0023] Component (A) has a hydroxy group, which is a hydrophilic moiety, and a hydrophobic moiety containing a C atom. From the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect, the (number of OH groups / number of C atoms) of component (A) is preferably less than 1, more preferably 0.95 or less, even more preferably 0.80 or less, still more preferably 0.70 or less, still more preferably 0.60 or less, still more preferably 0.50 or less, still more preferably 0.40 or less, still more preferably 0.35 or less, and is also preferably 0.10 or more, more preferably 0.15 or more, and still more preferably 0.18 or more. The (number of OH groups / number of C atoms) of component (A) is preferably less than 1, more preferably 0.10 to 0.95, even more preferably 0.15 to 0.80, still more preferably 0.15 to 0.70, still more preferably 0.15 to 0.60, still more preferably 0.15 to 0.50, still more preferably 0.15 to 0.40, still more preferably 0.15 to 0.35, and still more preferably 0.18 to 0.35.

[0024] The number of carbon atoms in component (A) is preferably 4 or more from the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect, and is preferably 24 or less, more preferably 20 or less, even more preferably 16 or less, still more preferably 12 or less, still more preferably 11 or less, and still more preferably 8 or less from the viewpoint of improving bactericidal and / or virucidal activity by distorting or destroying the three-dimensional hydrogen bond network of water. Furthermore, from the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect, the number of OH groups in component (A) is preferably 2 or more and 5 or less, more preferably 2 or more and 4 or less, and even more preferably 2 or more and 3 or less.

[0025] From the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect, component (A) is measured by IR, with the vertical axis representing absorbance and the horizontal axis representing wave number (cm -1 ) the wave number of the peak top due to OH stretching vibration is preferably 3300 cm -1More than 3318cm, preferably -1 and is usually 3452 cm -1 This is because it is believed that the higher the peak top wavenumber is on the side of higher wavenumbers, the more likely it is that the effect of distorting or destroying the three-dimensional hydrogen bond network of water can be obtained. The IR measurement of component (A) can be specifically carried out by the method described in the examples.

[0026] Specific examples of component (A) include chain polyols and polyols having a cyclic structure, and either of these can be used. The term "chain" in chain polyols includes both straight chains and branched chains. Component (A) is preferably a chain polyol from the viewpoint of improving the bactericidal and / or virucidal activity by distorting or destroying the three-dimensional hydrogen bond network of water, and is more preferably a chain polyol having 4 or more carbon atoms, and even more preferably a chain diol or chain triol having 4 or more carbon atoms, from the viewpoint of improving the bactericidal and / or virucidal activity by having a hydrophobic portion, and from the viewpoint of the sustained effect of the bactericidal and / or virucidal activity. In the chain polyol, the bonding position of the OH group is not particularly limited.

[0027] Examples of the linear polyol used as component (A) include linear diols such as 2,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 2,5-hexanediol, 1,6-hexanediol, 1,2-heptanediol, 1,7-heptanediol, 1,2-octanediol, 1,8-octanediol, 1,2-nonanediol, 1,9-nonanediol, 1,2-decanediol, 1,10-decanediol, 1,2-dodecanediol, 1,12-dodecanediol, 1,2-tetradecanediol, 1,2-hexadecanediol, and 1,16-hexadecanediol; linear triols such as 1,2,3-butanetriol, 1,2,4-butanetriol, 1,2,5-pentanetriol, 1,2,7-heptanetriol, 1,2,8-octanetriol, 1,2,9-nonanetriol, and 1,2,10-decanetriol; Branched diols or triols such as 2-methyl-1,3-propanediol, 2,2-dimethyl-1,3-propanediol, 3-methyl-1,3-butanediol, 2-methylpentane-2,4-diol, 2-ethyl-1,3-hexanediol, 2-butyl-2-ethyl-1,3-propanediol, 3-(2-ethylhexyloxy)-1,2-propanediol, (lauryl / myristyl) glycol hydroxypropyl ether, 3,7,11,15-tetramethylhexadecane-1,2,3-triol, and the like. Polymers such as polyethylene glycol, polyglycerin, and PPG-10 butanediol; and the like, and one or more of these can be used.

[0028] Among the above, from the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect, component (A) is preferably one or more selected from the group consisting of 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2,10-decanetriol, 2-methylpentane-2,4-diol, 2-ethyl-1,3-hexanediol, and 3-(2-ethylhexyloxy)-1,2-propanediol, more preferably one or more selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2,10-decanetriol, and 3-(2-ethylhexyloxy)-1,2-propanediol.

[0029] The content of component (A) in the liquid composition used in the present invention is 0.05% by mass or more, preferably 0.1% by mass or more, more preferably 0.2% by mass or more, even more preferably 0.3% by mass or more, still more preferably 0.5% by mass or more, and even more preferably 0.7% by mass or more, from the viewpoint of improving the bactericidal and / or virucidal activity and its sustained effect. Also, from the viewpoint of improving the feel of the composition when used, it is 30% by mass or less, preferably 20% by mass or less, more preferably 15% by mass or less, even more preferably 10% by mass or less, still more preferably 5.0% by mass or less, still more preferably 4.0% by mass or less, and even more preferably 3.0% by mass or less. The content of component (A) in the liquid composition used in the present invention is 0.05% by mass or more and 30% by mass or less, preferably 0.05% by mass or more and 20% by mass or less, more preferably 0.05% by mass or more and 15% by mass or less, even more preferably 0.05% by mass or more and 10% by mass or less, still more preferably 0.05% by mass or more and 5.0% by mass or less, even more preferably 0.1% by mass or more and 5.0% by mass or less, still more preferably 0.2% by mass or more and 5.0% by mass or less, still more preferably 0.3% by mass or more and 5.0% by mass or less, still more preferably 0.5% by mass or more and 5.0% by mass or less, still more preferably 0.5% by mass or more and 4.0% by mass or less, still more preferably 0.5% by mass or more and 3.0% by mass or less, and still more preferably 0.7% by mass or more and 3.0% by mass or less.

[0030] The liquid composition used in the present invention may contain, in addition to the component (A), a compound having a log P value of glycerin or the like, within a range that does not impair the effects of the present invention. owThe liquid composition of the present invention may contain a polyol (hereinafter also referred to as "component (A')") having a .DELTA..sub.(A') value <-0.3. When the liquid composition of the present invention contains component (A'), from the viewpoint of moisturizing property, its content in the composition is preferably 0.025% by mass or more, more preferably 0.05% by mass or more, even more preferably 0.1% by mass or more, still more preferably 0.15% by mass or more, still more preferably 0.25% by mass or more, still more preferably 0.35% by mass or more, and still more preferably 0.5% by mass or more. Furthermore, from the viewpoint of improving the feel of the composition when used, it is preferably 10% by mass or less, more preferably 7.0% by mass or less, even more preferably 5.0% by mass or less, still more preferably 2.5% by mass or less, still more preferably 2.0% by mass or less, and still more preferably 1.5% by mass or less. Furthermore, the proportion of component (A) in all polyols contained in the liquid composition used in the present invention (component (A) content / total polyol content × 100 (mass%)) is preferably 50 mass% or more, more preferably 70 mass% or more, and even more preferably 90 mass% or more, but 100 mass% or less.

[0031] <Component (B): Non-alcohol-based disinfectant> The liquid composition used in the present invention contains a non-alcoholic bactericide as component (B). Suitable component (B) includes one or more selected from the group consisting of cationic bactericides, iodine-based bactericides, phenol-based bactericides, biguanide-based bactericides, terpenoid-based bactericides, chlorine-based bactericides, and amphoteric surfactant-based bactericides. These bactericides are particularly suitable for use in skin topical compositions.

[0032] Examples of cationic disinfectants include quaternary ammonium salt compounds such as cetylpyridinium chloride, benzethonium chloride, and benzalkonium chloride. Examples of iodine-based disinfectants include povidone iodine, polyvinyl alcohol iodine, and cyclodextrin iodine. Phenol-based disinfectants include isopropylmethylphenol, triclosan, and phenoxyethanol. Examples of biguanide disinfectants include chlorhexidine gluconate. Examples of terpenoid fungicides include dipotassium glycyrrhizinate, stearyl glycyrrhetinate, and β-glycyrrhetinic acid. Examples of chlorine-based disinfectants include hypochlorous acid, sodium hypochlorite, calcium hypochlorite, and chlorinated isocyanuric acid. Examples of amphoteric surfactant-based disinfectants include alkyldiaminoethylglycine hydrochloride and alkylpolyaminoethylglycine.

[0033] The component (B) can be used alone or in combination of two or more. Among the above, from the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect, component (B) is preferably one or more selected from the group consisting of cationic bactericides, iodine-based bactericides, phenol-based bactericides, and biguanide-based bactericides, more preferably one or more selected from the group consisting of benzalkonium chloride, benzethonium chloride, povidone-iodine, and chlorhexidine gluconate, and even more preferably benzalkonium chloride.

[0034] The content of component (B) in the liquid composition used in the present invention is 0.01% by mass or more, preferably 0.02% by mass or more, more preferably 0.03% by mass or more, from the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect. Also, from the viewpoint of suppressing skin irritation and economical efficiency, it is 10% by mass or less, preferably 5.0% by mass or less, more preferably 3.0% by mass or less, even more preferably 1.0% by mass or less, still more preferably 0.5% by mass or less, even more preferably 0.2% by mass or less, still more preferably 0.1% by mass or less, still more preferably 0.07% by mass or less, and even more preferably 0.05% by mass or less. The content of component (B) in the liquid composition used in the present invention is 0.01% by mass or more and 10% by mass or less, preferably 0.01% by mass or more and 8.0% by mass or less, more preferably 0.01% by mass or more and 5.0% by mass or less, even more preferably 0.01% by mass or more and 3.0% by mass or less, still more preferably 0.01% by mass or more and 1.0% by mass or less, still more preferably 0.02% by mass or more and 0.5% by mass or less, still more preferably 0.02% by mass or more and 0.2% by mass or less, still more preferably 0.03% by mass or more and 0.1% by mass or less, still more preferably 0.03% by mass or more and 0.07% by mass or less, and still more preferably 0.03% by mass or more and 0.05% by mass or less.

[0035] The mass ratio (B / A) of component (B) to component (A) in the liquid composition used in the present invention is preferably 0.001 or more, more preferably 0.005 or more, and even more preferably 0.01 or more, from the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect. Furthermore, from the viewpoint of suppressing skin irritation and from the viewpoint of economy, it is preferably 5 or less, more preferably 1 or less, and even more preferably 0.1 or less. The mass ratio (B / A) of component (B) to component (A) in the liquid composition used in the present invention is preferably 0.001 or more and 5 or less, more preferably 0.005 or more and 1 or less, and even more preferably 0.01 or more and 0.1 or less.

[0036] The liquid composition used in the present invention may contain an alcohol-based disinfectant within a range that does not impair the effects of the present invention. When the liquid composition used in the present invention contains an alcohol-based disinfectant, its content in the composition is preferably 1% by mass or more, more preferably 5% by mass or more, and even more preferably 10% by mass or more, from the viewpoint of bactericidal and / or virucidal activity. Furthermore, from the viewpoint of suppressing skin irritation, it is preferably 80% by mass or less, more preferably 70% by mass or less, even more preferably 50% by mass or less, even more preferably 20% by mass or less, even more preferably 10% by mass or less, even more preferably 3% by mass or less, even more preferably 1% by mass or less, even more preferably 0.07% by mass or less, even more preferably 0.05% by mass or less, even more preferably 0.03% by mass or less, even more preferably less than 0.01% by mass, and most preferably substantially 0% by mass.

[0037] <Water> The liquid composition used in the present invention preferably further contains water from the viewpoint of dissolving component (A) and component (B) and facilitating application to a target object such as the skin surface. The water content in the liquid composition used in the present invention is preferably 10% by mass or more, more preferably 50% by mass or more, even more preferably 70% by mass or more, and preferably 99.45% by mass or less. The water content in the liquid composition used in the present invention is preferably 10% by mass or more and 99.45% by mass or less, more preferably 50% by mass or more and 99.45% by mass or less, even more preferably 70% by mass or more and 99.45% by mass or less.

[0038] From the viewpoint of obtaining the effects of the present invention, the total content of component (A), component (B), and water in the liquid composition used in the present invention is preferably 25% by mass or more, more preferably 50% by mass or more, even more preferably 70% by mass or more, still more preferably 90% by mass or more, still more preferably 95% by mass or more, and may be substantially 100% by mass.

[0039] The liquid composition used in the present invention and contained in the container may further contain one or more components selected from the group consisting of the following components (C) and (D), from the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect: Component (C): One or more surfactants selected from the group consisting of nonionic surfactants and anionic surfactants Component (D): organic acid or its salt

[0040] <Component (C): Surfactant> Component (C) is one or more surfactants selected from the group consisting of nonionic surfactants and anionic surfactants. Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene alkenyl ethers, sucrose fatty acid esters, polyoxyethylene fatty acid esters, polyglyceryl alkyl ethers, fatty acid polyglyceryl, sorbitan fatty acid esters, alkyl glucosides, polyoxyethylene alkylamines, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene sorbit fatty acid esters, and one or more of these can be used.

[0041] Of the above, the alkyl group in the polyoxyethylene alkyl ether, polyglyceryl alkyl ether, alkyl glucoside, and polyoxyethylene alkylamine, the alkenyl group in the polyoxyethylene alkenyl ether, and the fatty acid in the sucrose fatty acid ester, polyoxyethylene fatty acid ester, fatty acid polyglyceryl, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, and polyoxyethylene sorbit fatty acid ester preferably has from 8 to 22 carbon atoms, more preferably from 10 to 22 carbon atoms, and even more preferably from 10 to 18 carbon atoms, from the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect.

[0042] Furthermore, from the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect, the average number of moles of oxyethylene groups added in polyoxyethylene alkyl ethers, polyoxyethylene alkenyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene alkylamines, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene sorbit fatty acid esters (hereinafter referred to as "average number of moles of EO added") is preferably 2 or more, more preferably 3 or more, and preferably 20 or less, more preferably 15 or less, and even more preferably 10 or less. The average number of moles of EO added is preferably 2 or more and 20 or less, more preferably 3 or more and 20 or less, even more preferably 3 or more and 15 or less, and even more preferably 3 or more and 10 or less. Note that the average number of moles of EO added is a number average value.

[0043] Examples of anionic surfactants include alkylbenzenesulfonates, alkyl or alkenyl ether sulfates, alkyl or alkenyl sulfates, alkyl sulfonates, saturated or unsaturated fatty acid salts, alkyl or alkenyl ether carboxylates, α-sulfofatty acid salts, N-acylamino acids, mono- or di-phosphate esters, and sulfosuccinate esters, and one or more of these can be used. Counter ions of the anionic group in anionic surfactants include alkali metal ions such as sodium ion and potassium ion; alkaline earth metal ions such as calcium ion and magnesium ion; ammonium ion; and alkanolammonium having 1 to 3 alkanol groups having 2 or 3 carbon atoms (for example, monoethanolammonium, diethanolammonium, triethanolammonium, triisopropanolammonium, etc.). Among the above, one or more selected from the group consisting of alkyl sulfates, alkyl ether sulfates, and alkyl ether carboxylates are preferred. Examples of the alkyl ether sulfates include polyoxyethylene alkyl ether sulfates such as sodium laureth sulfate, and examples of the alkyl ether carboxylates include polyoxyethylene alkyl ether acetates such as sodium laureth acetate.

[0044] One or more types of component (C) can be used. Among the above, from the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect, nonionic surfactants are preferred as component (C), more preferably one or more selected from the group consisting of polyoxyethylene alkyl ethers, polyoxyethylene alkenyl ethers, sucrose fatty acid esters, polyoxyethylene fatty acid esters, polyglyceryl alkyl ethers, fatty acid polyglyceryls, alkyl glucosides, and polyoxyethylene alkylamines, even more preferably one or more selected from the group consisting of polyoxyethylene alkyl ethers, polyoxyethylene alkenyl ethers, and polyoxyethylene fatty acid esters, and even more preferably polyoxyethylene alkyl ethers.

[0045] When the liquid composition used in the present invention contains component (C), the content of component (C) in the liquid composition is preferably 0.01% by mass, more preferably 0.05% by mass or more, even more preferably 0.1% by mass or more, still more preferably 0.2% by mass or more, and even more preferably 0.3% by mass or more, from the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect. Furthermore, from the viewpoint of improving skin irritation suppression and economic efficiency, the content is preferably 5.0% by mass or less, more preferably 3.0% by mass or less, and even more preferably 1.0% by mass or less. The content of component (C) in the liquid composition used in the present invention is preferably 0.01% by mass or more to 5.0% by mass or less, more preferably 0.05% by mass or more to 3.0% by mass or less, even more preferably 0.1% by mass or more to 3.0% by mass or less, still more preferably 0.2% by mass or more to 3.0% by mass or less, and even more preferably 0.3% by mass or more to 1.0% by mass or less. When the liquid composition used in the present invention contains an anionic surfactant as component (C), its content is determined based on the dissociation state of the anionic surfactant in the liquid composition. For example, if the anionic surfactant is present in the liquid composition in a dissociated form, the content is determined as the amount of the dissociated form.

[0046] <Component (D): Organic acid or its salt> Examples of organic acids used as component (D) include lactic acid, pyruvic acid, urocanic acid, acetic acid, glycolic acid, malic acid, tartaric acid, citric acid, succinic acid, fumaric acid, and adipic acid, and one or more of these can be used. From the viewpoints of bactericidal and / or virucidal activity, improving the sustained effect thereof, and reducing skin irritation, component (D) is preferably one or more selected from the group consisting of lactic acid, pyruvic acid, and urocanic acid. Examples of salts of lactic acid, pyruvic acid, and urocanic acid include alkali metal salts of lactic acid or pyruvic acid, such as potassium salts and sodium salts; alkaline earth metal salts, such as calcium salts and magnesium salts; amine salts; ammonium salts, etc. Among these, from the viewpoints of improving bactericidal and / or virucidal activity and easy availability, one or more selected from the group consisting of alkali metal salts and alkaline earth metal salts of lactic acid, pyruvic acid, and urocanic acid are preferred, one or more selected from the group consisting of potassium salts, sodium salts, and calcium salts are more preferred, and one or more selected from the group consisting of potassium lactate, sodium lactate, and calcium lactate are even more preferred. From the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect, component (D) is more preferably lactic acid or a salt thereof, more preferably one or more selected from the group consisting of lactic acid, potassium lactate, sodium lactate, and calcium lactate, and even more preferably lactic acid.

[0047] When the liquid composition used in the present invention contains component (D), the content of component (D) in the liquid composition is preferably 0.1% by mass or more, more preferably 0.3% by mass or more, and even more preferably 0.5% by mass or more, from the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect. Furthermore, from the viewpoint of suppressing skin irritation and economic efficiency, the content is preferably 10.0% by mass or less, more preferably 5.0% by mass or less, even more preferably 3.0% by mass or less, and even more preferably 2.0% by mass or less. The content of component (D) in the liquid composition used in the present invention is preferably 0.1% by mass or more and 10.0% by mass or less, more preferably 0.3% by mass or more and 5.0% by mass or less, even more preferably 0.3% by mass or more and 3.0% by mass or less, and even more preferably 0.5% by mass or more and 2.0% by mass or less. In this specification, when component (D) contains a salt, the "content of component (D)" means the amount converted into the acid.

[0048] The total content of components (C) and (D) in the liquid composition used in the present invention is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, even more preferably 0.2% by mass or more, and even more preferably 0.3% by mass or more, from the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect, and is preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 10% by mass or less, still more preferably 5.0% by mass or less, and even more preferably 3.0% by mass or less, from the viewpoint of suppressing skin irritation and from the viewpoint of economy. The total content of components (C) and (D) in the liquid composition used in the present invention is preferably 0.01% by mass or more and 15% by mass or less, more preferably 0.1% by mass or more and 12% by mass or less, even more preferably 0.2% by mass or more and 10% by mass or less, still more preferably 0.3% by mass or more and 5.0% by mass or less, and even more preferably 0.3% by mass or more and 3.0% by mass or less.

[0049] <Other ingredients> In addition to the above, the liquid composition used in the present invention may also contain other ingredients, as needed, such as thickeners, pH adjusters (hydrochloric acid, sodium hydroxide, etc.), ultraviolet absorbers, antioxidants, preservatives, antiperspirants, fragrances, moisturizers, texture adjusters, anti-inflammatory agents, etc.

[0050] The liquid composition used in the present invention preferably has a low zinc content. This is because zinc has the effect of inhibiting the bactericidal properties of component (B) (particularly benzalkonium chloride). More specifically, the zinc content in the liquid composition used in the present invention, in terms of the amount of zinc salt, is preferably 0.2% by mass or less, more preferably 0.1% by mass or less, even more preferably 0.01% by mass or less, and even more preferably substantially 0% by mass. From the same viewpoint as above, the total amount of divalent and trivalent metal ions in the liquid composition used in the present invention is preferably 0.2% by mass or less, more preferably 0.1% by mass or less, even more preferably 0.01% by mass or less, and even more preferably substantially 0% by mass.

[0051] <ph> The liquid composition used in the present invention has a pH of 3.5 or higher, preferably 3.7 or higher, and more preferably 4.0 or higher, from the viewpoint of suppressing skin irritation. Furthermore, from the viewpoint of improving bactericidal and / or virucidal activity and its sustained effect, the pH is 7.0 or lower, preferably 6.0 or lower, more preferably 5.5 or lower, even more preferably 5.0 or lower, and even more preferably 4.5 or lower. The specific pH range of the liquid composition used in the present invention is 3.5 or higher and 7.0 or lower, preferably 3.7 or higher and 6.0 or lower, more preferably 3.7 or higher and 5.5 or lower, even more preferably 4.0 or higher and 5.0 or lower, and even more preferably 4.0 or higher and 4.5 or lower. The pH is measured at 25° C., and can be measured by the method described in the Examples.

[0052] The liquid composition used in the present invention may be any composition as long as it has fluidity at 25°C. The form of the liquid composition is not particularly limited, and it may be, for example, liquid, gel, or cream. From the viewpoint of ease of application to the skin, the composition of the present invention is preferably in the form of a gel or cream. The liquid composition may be in the form of an emulsion composition, and the emulsion composition may be either an oil-in-water emulsion composition or a water-in-oil emulsion composition.

[0053] From the viewpoint of preventing contact infection by bacteria or viruses, the liquid composition used in the present invention is preferably a topical skin composition for use on hands, among other topical skin compositions. Furthermore, from the viewpoint of preventing contact infection by bacteria or viruses, the packaged liquid composition of the present invention is preferably a topical skin composition for use on hands, among other topical skin compositions. Examples of product forms include hand disinfectants and hand cream cosmetics.

[0054] [Defense method] The present invention also provides a method for protecting skin from bacteria or viruses using the containerized liquid composition of the present invention, which comprises a step of applying the liquid composition contained in the container to the skin (hereinafter also referred to as the "method of the present invention"). According to the method of the present invention, the skin can be protected from bacteria or viruses. The bacteria or viruses to be protected from by the method of the present invention are the same as those described above. The method for applying the liquid composition to the skin can be appropriately selected depending on the application site, etc. For example, the liquid composition contained in a container can be applied by painting or spraying it onto the skin surface.

[0055] In this specification, "protecting the skin from bacteria or viruses" encompasses concepts such as (1) a bactericidal or virucidal effect exerted against bacteria or viruses adhering to the skin surface after the composition is applied to the skin surface, (2) a bactericidal or virucidal effect exerted against bacteria or viruses adhering to the skin by applying the composition, (3) an effect of preparing the skin so that bacteria or viruses are not transmitted through the skin, (4) an effect of protecting the skin from bacteria or viruses and keeping it hygienic, (5) an effect of preventing the spread of bacteria or viruses through the skin and contact infection, and (6) an effect of enhancing the skin's ability to defend against infections from bacteria and viruses.

[0056] In the method of the present invention, after applying the liquid composition to the skin, it is preferable to leave the liquid composition on the skin surface without removing it by rinsing with water, etc. This is because when the liquid composition is used as a leave-on external skin preparation composition, the bactericidal and virucidal components, component (A) and component (B), remain on the skin surface, thereby imparting a bactericidal and / or virucidal effect to the skin surface.

[0057] In this step, the amount of the liquid composition to be applied is not particularly limited as long as it is an amount that can impart bactericidal and / or virucidal activity to the skin surface. From the viewpoint of imparting high bactericidal and / or virucidal activity and its persistence, the amount of the liquid composition to be applied in this step is set so that the amount of component (A) is sufficient to cover 1 cm of skin. 2 The amount is preferably 0.0005 mg or more, more preferably 0.001 mg or more, even more preferably 0.002 mg or more, still more preferably 0.005 mg or more, still more preferably 0.01 mg or more, and still more preferably 0.02 mg or more per 1 cm of skin. From the viewpoint of improving the feeling of use and from the viewpoint of economy, the amount is preferably 1.0 mg or less, more preferably 0.5 mg or less, and still more preferably 0.2 mg or less. The amount of the composition to be applied is such that the amount of component (A) per 1 cm of skin is 2 The amount is preferably 0.0005 mg or more and 1.0 mg or less, more preferably 0.001 mg or more and 1.0 mg or less, even more preferably 0.002 mg or more and 1.0 mg or less, still more preferably 0.005 mg or more and 1.0 mg or less, still more preferably 0.01 mg or more and 0.5 mg or less, and even more preferably 0.02 mg or more and 0.2 mg or less.

[0058] The liquid composition may be applied to the skin after washing the skin in advance with water, soap, body soap, hand soap, etc., or may be applied to unwashed skin. After washing, naturally occurring components such as lactic acid are washed away from the skin, and the skin's defense ability against bacteria and viruses present in the environment is reduced. Therefore, it is more preferable to carry out the method of the present invention by applying the liquid composition to the skin after washing.

[0059] [use] The present invention also provides a method for enhancing or sustaining the bactericidal effect of a non-alcohol-based bactericide (B) on the skin, comprising: ow The present invention provides the use of a polyol (A) that satisfies a value of ≧−0.3. The specific polyol (A) can enhance or sustain the bactericidal effect on the skin by using it in combination with the bactericide (B) based on the above-mentioned mechanism of action. In the above, the fungicide (B), the polyol (A), and the preferred embodiments thereof are the same as the above-mentioned component (B) and component (A), respectively.

[0060] The present invention further comprises: Component (A):logP ow one or more polyols satisfying a value of ≧−0.3; Ingredient (B): Non-alcohol-based disinfectant, The present invention also provides use of a liquid composition comprising the above, wherein the content of component (A) is from 0.05% by mass to 30% by mass, the content of component (B) is from 0.01% by mass to 10% by mass, the content of glycerol trioctanoate is less than 2% by mass, and the pH at 25°C is from 3.5 to 7.0, as a bactericidal and / or virucidal external preparation for skin. In the above, the components (A) and (B) and their preferred embodiments are the same as those described above.

[0061] In relation to the above-described embodiments, the present invention further discloses the following. <1> Component (A):logP ow one or more polyols satisfying a value of ≧−0.3, and Ingredient (B): Non-alcohol-based disinfectant, Contains The content of the component (A) is 0.05% by mass or more and 30% by mass or less, The content of the component (B) is 0.01% by mass or more and 10% by mass or less, A containerized liquid composition containing a liquid composition having a glycerin trioctanoate content of less than 2% by mass and a pH of 3.5 or more and 7.0 or less at 25°C, the liquid composition being contained in a container. <2> Log P of component (A) ow The value is preferably 0.0 or more and 2.0 or less, more preferably 0.2 or more and 2.0 or less, even more preferably 0.2 or more and 1.0 or less, and even more preferably 0.5 or more and 0.7 or less. <1> The container-packed liquid composition according to claim 1. <3> The (number of OH groups / number of C atoms) of component (A) is preferably less than 1, more preferably 0.10 or more and 0.95 or less, even more preferably 0.15 or more and 0.80 or less, still more preferably 0.15 or more and 0.70 or less, still more preferably 0.15 or more and 0.60 or less, still more preferably 0.15 or more and 0.50 or less, still more preferably 0.15 or more and 0.40 or less, still more preferably 0.15 or more and 0.35 or less, and still more preferably 0.18 or more and 0.35 or less. <1> The container-packed liquid composition according to claim 1. <4> In the IR measurement of component (A), the vertical axis represents absorbance and the horizontal axis represents wave number (cm -1 ) the wave number of the peak top due to OH stretching vibration is preferably 3300 cm -1 More than 3318cm, preferably -1 That is 3452cm -1 Below is the <1> or <2> The container-packed liquid composition according to claim 1. <5> The number of OH groups in component (A) is preferably 2 or more and 5 or less, more preferably 2 or more and 4 or less, and even more preferably 2 or more and 3 or less. <1> ~ <4> The container-packed liquid composition according to any one of the above. <6> Component (A) is a chain polyol having 4 or more carbon atoms, preferably a chain diol or chain triol having 4 or more carbon atoms. <1> ~ <5> The container-packed liquid composition according to any one of the above. <7> Component (A) is preferably one or more selected from the group consisting of 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2,10-decanetriol, 2-methylpentane-2,4-diol, 2-ethyl-1,3-hexanediol, and 3-(2-ethylhexyloxy)-1,2-propanediol, more preferably one or more selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2,10-decanetriol, and 3-(2-ethylhexyloxy)-1,2-propanediol, <1> ~ <6> The container-packed liquid composition according to any one of the above. <8> The content of component (A) in the liquid composition is 0.05% by mass or more and 30% by mass or less, preferably 0.05% by mass or more and 20% by mass or less, more preferably 0.05% by mass or more and 15% by mass or less, even more preferably 0.05% by mass or more and 10% by mass or less, still more preferably 0.05% by mass or more and 5.0% by mass or less, still more preferably 0.1% by mass or more and 5.0% by mass or less, still more preferably 0.2% by mass or more and 5.0% by mass or less, still more preferably 0.3% by mass or more and 5.0% by mass or less, still more preferably 0.5% by mass or more and 5.0% by mass or less, still more preferably 0.5% by mass or more and 4.0% by mass or less, still more preferably 0.5% by mass or more and 3.0% by mass or less, and still more preferably 0.7% by mass or more and 3.0% by mass or less, <1> ~ <7> The container-packed liquid composition according to any one of the above. <9> The proportion of component (A) in the total polyol contained in the liquid composition is preferably 50% by mass or more, more preferably 70% by mass or more, and even more preferably 90% by mass or more and 100% by mass or less. <1> ~ <8> The container-packed liquid composition according to any one of the above. <10> Component (B) is one or more selected from the group consisting of cationic disinfectants, iodine-based disinfectants, phenol-based disinfectants, biguanide-based disinfectants, terpenoid-based disinfectants, chlorine-based disinfectants, and amphoteric surfactant-based disinfectants, preferably one or more selected from the group consisting of cationic disinfectants, iodine-based disinfectants, phenol-based disinfectants, and biguanide-based disinfectants, more preferably one or more selected from the group consisting of benzalkonium chloride, benzethonium chloride, povidone-iodine, and chlorhexidine gluconate, and even more preferably benzalkonium chloride; <1> ~ <9> The container-packed liquid composition according to any one of the above.

[0062] <11> The content of component (B) in the liquid composition is preferably 0.01% by mass or more and 8.0% by mass or less, more preferably 0.01% by mass or more and 5.0% by mass or less, even more preferably 0.01% by mass or more and 3.0% by mass or less, still more preferably 0.01% by mass or more and 1.0% by mass or less, still more preferably 0.02% by mass or more and 0.5% by mass or less, still more preferably 0.02% by mass or more and 0.2% by mass or less, still more preferably 0.03% by mass or more and 0.1% by mass or less, still more preferably 0.03% by mass or more and 0.07% by mass or less, and still more preferably 0.03% by mass or more and 0.05% by mass or less, <1> ~ <10> The container-packed liquid composition according to any one of the above. <12> The mass ratio (B / A) of component (B) to component (A) in the liquid composition is preferably 0.001 or more and 5 or less, more preferably 0.005 or more and 1 or less, and even more preferably 0.01 or more and 0.1 or less. <1> ~ <11> The container-packed liquid composition according to any one of the above. <13> the liquid composition further contains water, and the content of water in the liquid composition is preferably 10% by mass or more and 99.45% by mass or less, more preferably 50% by mass or more and 99.45% by mass or less, and even more preferably 70% by mass or more and 99.45% by mass or less; <1> ~ <12> The container-packed liquid composition according to any one of the above. <14> The total content of component (A), component (B), and water in the liquid composition is preferably 25% by mass or more, more preferably 50% by mass or more, even more preferably 70% by mass or more, still more preferably 90% by mass or more, and even more preferably 95% by mass or more. <1> ~ <13> The container-packed liquid composition according to any one of the above. <15> Furthermore, the liquid composition contained in the container contains one or more components selected from the group consisting of the following components (C) and (D): <1> ~ <14> The container-packed liquid composition according to any one of the above. Component (C): One or more surfactants selected from the group consisting of nonionic surfactants and anionic surfactants Component (D): organic acid or its salt <16> Component (C) is preferably a nonionic surfactant, more preferably one or more selected from the group consisting of polyoxyethylene alkyl ethers, polyoxyethylene alkenyl ethers, sucrose fatty acid esters, polyoxyethylene fatty acid esters, polyglyceryl alkyl ethers, fatty acid polyglyceryls, alkyl glucosides, and polyoxyethylene alkylamines, even more preferably one or more selected from the group consisting of polyoxyethylene alkyl ethers, polyoxyethylene alkenyl ethers, and polyoxyethylene fatty acid esters, and even more preferably polyoxyethylene alkyl ethers. <15> The container-packed liquid composition according to claim 1. <17> The content of component (C) in the liquid composition is preferably 0.01% by mass or more and 5.0% by mass or less, more preferably 0.05% by mass or more and 3.0% by mass or less, even more preferably 0.1% by mass or more and 3.0% by mass or less, still more preferably 0.2% by mass or more and 3.0% by mass or less, and even more preferably 0.3% by mass or more and 1.0% by mass or less. <15> or <16> The container-packed liquid composition according to claim 1. <18> The organic acid used as component (D) is at least one selected from the group consisting of lactic acid, pyruvic acid, urocanic acid, acetic acid, glycolic acid, malic acid, tartaric acid, citric acid, succinic acid, fumaric acid, and adipic acid, preferably at least one selected from the group consisting of lactic acid, pyruvic acid, and urocanic acid. <15> ~ <17> The container-packed liquid composition according to any one of the above. <19> Component (D) is lactic acid or a salt thereof, preferably one or more selected from the group consisting of lactic acid, potassium lactate, sodium lactate, and calcium lactate, more preferably lactic acid. <18> The container-packed liquid composition according to claim 1. <20> The content of component (D) in the liquid composition is preferably 0.1% by mass or more and 10.0% by mass or less, more preferably 0.3% by mass or more and 5.0% by mass or less, even more preferably 0.3% by mass or more and 3.0% by mass or less, and still more preferably 0.5% by mass or more and 2.0% by mass or less. <15> ~ <19> The container-packed liquid composition according to any one of the above.

[0063] <21> The total content of component (C) and component (D) in the liquid composition is preferably 0.01% by mass or more and 15% by mass or less, more preferably 0.1% by mass or more and 12% by mass or less, even more preferably 0.2% by mass or more and 10% by mass or less, still more preferably 0.3% by mass or more and 5.0% by mass or less, and even more preferably 0.3% by mass or more and 3.0% by mass or less. <15> ~ <20> The container-packed liquid composition according to any one of the above. <22> The pH of the liquid composition at 25°C is preferably 3.7 or more and 6.0 or less, more preferably 3.7 or more and 5.5 or less, even more preferably 4.0 or more and 5.0 or less, and still more preferably 4.0 or more and 4.5 or less. <1> ~ <21> The container-packed liquid composition according to any one of the above. <23> The content of glycerol trioctanoate in the liquid composition is preferably 1.9% by mass or less, more preferably 1.8% by mass or less, even more preferably 1.5% by mass or less, still more preferably 1% by mass or less, still more preferably 0.5% by mass or less, even more preferably 0.2% by mass or less, still more preferably 0.1% by mass or less, still more preferably 0.05% by mass or less, and still more preferably substantially 0% by mass. <1> ~ <22> The container-packed liquid composition according to any one of the above. <24> The content of triglycerides in the liquid composition whose constituent fatty acids are saturated fatty acids having 8 or more carbon atoms is preferably less than 2.0% by mass, more preferably 1.9% by mass or less, even more preferably 1.8% by mass or less, and even more preferably 1.5% by mass or less. <1> ~ <23> The container-packed liquid composition according to any one of the above. <25> The triglyceride content in the liquid composition is preferably less than 2.0% by mass, more preferably 1.9% by mass or less, even more preferably 1.8% by mass or less, and even more preferably 1.5% by mass or less. <1> ~ <24> The container-packed liquid composition according to any one of the above. <26> The content of oily components in the liquid composition is preferably 5% by mass or less, more preferably 4.5% by mass or less, more preferably 3% by mass or less, even more preferably less than 2% by mass, still more preferably 1.9% by mass or less, even more preferably 1.8% by mass or less, even more preferably 1.5% by mass or less, even more preferably 1% by mass or less, even more preferably 0.5% by mass or less, even more preferably 0.2% by mass or less, even more preferably 0.1% by mass or less, even more preferably 0.05% by mass or less, and even more preferably substantially 0% by mass. <1> ~ <25> The container-packed liquid composition according to any one of the above. <27> The liquid composition contained in the container is a leave-on skin topical composition, preferably a leave-on skin topical composition for hands and fingers. <1> ~ <26> The container-packed liquid composition according to any one of the above. <28> <1> ~ <27> 10. A method for protecting skin from bacteria or viruses, comprising the step of applying the container-packed liquid composition according to any one of the above items to the skin. <29> In the step of applying the liquid composition to the skin, the amount of the packaged liquid composition to be applied is such that the amount of component (A) is sufficient to cover 1 cm of skin. 2 Preferably, the amount is 0.0005 mg or more and 1.0 mg or less, more preferably 0.001 mg or more and 1.0 mg or less, even more preferably 0.002 mg or more and 1.0 mg or less, still more preferably 0.005 mg or more and 1.0 mg or less, still more preferably 0.01 mg or more and 0.5 mg or less, and even more preferably 0.02 mg or more and 0.2 mg or less. <28> The method described below. <30> applying the packaged liquid composition to the cleansed skin; <28> or <29> The method described below.

[0064] <31> The logP value for enhancing or sustaining the bactericidal effect of non-alcoholic disinfectants (B) on the skin ow Use of polyol (A) satisfying a value of ≧−0.3. <32> Component (A):logP ow one or more polyols satisfying a value of ≧−0.3, and Ingredient (B): Non-alcohol-based disinfectant, Use of a liquid composition comprising the above, wherein the content of component (A) is from 0.05% by mass to 30% by mass, the content of component (B) is from 0.01% by mass to 10% by mass, the content of glycerin trioctanoate is less than 2% by mass, and the pH at 25°C is from 3.5 to 7.0, as a bactericidal and / or virucidal external preparation for skin. [Example]

[0065] The present invention will be described below with reference to examples, but the present invention is not limited to the scope of the examples. In the examples, various measurements and evaluations were carried out by the following methods.

[0066] (pH) The pH of the liquid composition was measured at 25°C using a pH meter (electrode: 6367-10D (manufactured by Horiba, Ltd.)).

[0067] (IR measurement) The polyols listed in Table 1 were used as measurement samples, and IR measurements were carried out by the ATR method using an infrared spectrophotometer (PerkinElmer "Spectrum 400, Universal ATR unit"), with a diamond / ZnSe crystal and a resolution of 4 cm. -1 , 16 times accumulation, 4000~650cm -1 The measurements were carried out in a range of 22°C room temperature and 35% RH. The vertical axis of the chart represents absorbance, and the horizontal axis represents wavenumber (cm -1 ) as 3250~3452cm -1 The wavenumber of the peak top in the range of OH stretching vibration (cm -1 ) are shown in Table 1.

[0068] (logP ow value) Log P of polyols listed in Table 1 ow The values ​​are taken from the chemical database "PubChem" and calculated using the aforementioned algorithm "XLOGP3."

[0069] (Preparation of bacterial solution) For the evaluation of bactericidal activity, a Serratia bacterial suspension prepared by the following method was used. The NBRC12648 strain was used as the Serratia marcescens. This bacterium was cultured in LB liquid medium, and the cells were collected by centrifugation. The OD 600 It was adjusted to be 10. (Bactericidal evaluation) [a. Bactericidal activity (log reduction value) immediately after application of the liquid composition] The inner forearm of each subject was washed with "Biore u Rg" (manufactured by Kao Corporation). After waiting for 5 to 10 minutes, the liquid compositions shown in Tables 2 to 6 were applied to the skin surface of the inner forearm (7.5 cm 2 In Comparative Examples 2 and 3, the coating was applied to the stainless steel surface and the glass surface, respectively, and spread evenly to the application amounts shown in each table. After leaving the composition to stand for 5 minutes and drying, a fixed amount (7.5 μL / 7.5 cm ) of the Serratia bacteria liquid prepared by the above method was applied to the skin surface after application of the liquid composition. 2 After leaving the sample in this state for a predetermined time (the "contact time with bacteria" shown in the table), the applied bacterial solution was collected using two swabs. Next, the number of viable bacteria was measured by the following method using an incubation reader "HiTS" (manufactured by Synix Co., Ltd.), and the reduction in the number of bacteria (number of viable bacteria / initial number of viable bacteria) was confirmed. Liquid culture was performed at 37°C in an incubation reader "HiTS," and the absorbance (turbidity) at a wavelength of 600 nm was measured over time to create a growth curve of the number of viable bacteria in the bacterial solution. At the same time, a bacterial solution with a known number of viable bacteria was serially diluted, and similarly cultured and a growth curve was created, creating a calibration curve of the time to reach a certain turbidity and the number of viable bacteria. From the relationship between the time to reach a certain turbidity for each sample and the calibration curve, the number of viable bacteria in the collected bacterial solution was estimated, and the reduction in the number of bacteria was confirmed. The degree of reduction in the number of bacteria (logarithmic reduction value) was calculated by taking the -log value of the reduction in the number of bacteria and is shown as "Evaluation result a" in Tables 2 to 6. A larger value indicates a higher bactericidal activity.

[0070] [b. Evaluation of the persistence of liquid compositions: bactericidal activity after time (log reduction)] The same procedure as in a. above was carried out, except that the standing time (5 minutes) after application of the liquid composition shown in Table 3 to the object to be treated was changed to the "standing time for evaluating sustainability" shown in each table. The degree of reduction in the number of bacteria (logarithmic reduction value) was calculated as the -log value of the reduction in the number of bacteria, and this is shown as "Evaluation result b" in Table 3. The larger this value, the higher the bactericidal activity.

[0071] [c. Bactericidal activity (log reduction value) immediately after application of a liquid composition (pure water) containing no added ingredients] The bactericidal activity was evaluated in the same manner as in a. above, except that pure water was used in place of the compositions shown in Tables 2 to 6 (evaluation result c).

[0072] [d. Evaluation of the persistence of the liquid composition (pure water) without added ingredients: bactericidal activity (log reduction value) after the passage of time] Pure water was used instead of the composition shown in Table 3, and the bactericidal activity was evaluated in the same manner as in c. above (evaluation result d).

[0073] Furthermore, the difference (ac) between evaluation results a and c, and the difference (bd) between evaluation results b and d were calculated and are shown in Tables 2 to 6. The larger the value of (ac), the greater the bactericidal effect immediately after application (initial stage) of the liquid composition, and the larger the value of (bd), the greater the bactericidal effect even after some time has passed since the liquid composition was applied.

[0074] Examples 1 to 15 and Comparative Examples 1 to 9 (Preparation and Evaluation of Liquid Compositions) The components shown in Tables 2 to 6 were blended in the amounts shown in Tables 2 to 6, mixed at room temperature, and then the pH was adjusted to the value shown in each table using a 1 mol / L aqueous hydrochloric acid solution (manufactured by FUJIFILM Wako Pure Chemical Industries, Ltd.) and / or a 1 mol / L aqueous sodium hydroxide solution (manufactured by FUJIFILM Wako Pure Chemical Industries, Ltd.) as a pH adjuster to prepare liquid compositions. The blending amounts shown in Tables 2 to 6 are the amount of active ingredient (% by mass) of each component. The bactericidal activity of the obtained liquid composition was evaluated by the above-mentioned method. The results are shown in Tables 2 to 6. Details of component (A) used in Tables 2 to 6, and component (A'), which is a polyol other than component (A), are shown in Table 1.

[0075] [Table 1]

[0076] [Table 2]

[0077] [Table 3]

[0078] [Table 4]

[0079] [Table 5]

[0080] [Table 6]

[0081] *1: 3-(2-ethylhexyloxy)-1,2-propanediol, manufactured by Tokyo Chemical Industry Co., Ltd. *2: Benzalkonium chloride "Benzalkonium chloride (50% aqueous solution)" manufactured by Tokyo Chemical Industry Co., Ltd. *3: Glycerin trioctanoate "Tricaprilin" manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. *4: 1,2-Pentanediol manufactured by Tokyo Chemical Industry Co., Ltd. *5: 1,5-Pentanediol, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. *6: 1,2-Hexanediol, manufactured by Tokyo Chemical Industry Co., Ltd. *7: 1,2-octanediol manufactured by Tokyo Chemical Industry Co., Ltd. *8: 1,2,10-Decanetriol, manufactured by Tokyo Chemical Industry Co., Ltd. *9: 2-Methyl-1,3-propanediol manufactured by Tokyo Chemical Industry Co., Ltd. *10: 2-Methylpentane-2,4-diol, manufactured by Tokyo Chemical Industry Co., Ltd. *11: 2-Ethyl-1,3-hexanediol "2-Ethyl-1,3-hexanediol (mixture of isomers)" manufactured by Tokyo Chemical Industry Co., Ltd. *12: Glycerol "Glycerin" manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. *13: Propylene glycol, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. *14: 1,3-Butylene glycol Fujifilm Wako Pure Chemical Industries, Ltd. "1,3-Butanediol" *15: 1,2,6-Hexanetriol, manufactured by Tokyo Chemical Industry Co., Ltd. *16: Tripropylene glycol "Tripropylene glycol (mixture of isomers)" manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. *17: Polyoxyethylene (6) lauryl ether "Emulgen 108" manufactured by Kao Corporation *18: Lactic acid Fujifilm Wako Pure Chemical Industries, Ltd. "Lactic acid (active: 90%)"

[0082] Tables 2 to 6 show that when the liquid composition of this example is applied to the skin surface, it has excellent bactericidal effect and its durability, and the combined use of component (A) and component (B) also produces a high synergistic effect. Furthermore, a comparison of Comparative Example 1 with Comparative Examples 2 and 3 in Table 2 shows that when the liquid composition is applied to skin, it is difficult to obtain a bactericidal effect from the bactericide compared to stainless steel or glass. [Industrial Applicability]

[0083] According to the present invention, it is possible to provide a packaged liquid composition that has excellent bactericidal and / or virucidal activity and a sustained effect, particularly when applied to the skin surface. The packaged liquid composition is useful as a packaged liquid composition for external use on the skin for bactericidal and / or virucidal purposes.< / ph>

Claims

1. Component (A): logP ｏｗ One or more polyols satisfying a value of ≧−0.3, and Component (B): a disinfectant other than alcohol-based, Contains The content of the component (A) is 0.05% by mass or more and 30% by mass or less, The content of the component (B) is 0.01% by mass or more and 10% by mass or less, A containerized liquid composition comprising a liquid composition having a glycerin trioctanoate content of less than 2% by mass and a pH of 3.5 or more and 7.0 or less at 25° C., the liquid composition being contained in a container.

2. 2. The bottled liquid composition according to claim 1, wherein the component (A) is a chain polyol having 4 or more carbon atoms.

3. 3. The containerized liquid composition according to claim 1 or 2, wherein the component (B) is one or more selected from the group consisting of cationic bactericides, iodine bactericides, phenolic bactericides, biguanide bactericides, terpenoid bactericides, chlorine bactericides, and amphoteric surfactant bactericides.

4. The containerized liquid composition according to claim 1 or 2, further comprising one or more components selected from the group consisting of the following components (C) and (D): Component (C): One or more surfactants selected from the group consisting of nonionic surfactants and anionic surfactants Component (D): Organic acid or its salt

5. 3. The bottled liquid composition according to claim 1, wherein the component (A) has a ratio of (number of OH groups / number of C atoms) of less than 1.

6. 3. The container-packed liquid composition according to claim 1, wherein the liquid composition contained in the container is a leave-on skin topical composition.

7. 3. A method for protecting skin from bacteria or viruses, comprising the step of applying the container-packed liquid composition according to claim 1 or 2 to the skin.

8. To enhance or sustain the bactericidal effect of a non-alcohol-based bactericide (B) on the skin, a logP ｏｗ Use of a polyol (A) satisfying a value ≧−0.3.