Systems and methods for organ maintenance and transport

The normothermal renal perfusion system addresses the challenges of maintaining kidney health during transport by providing real-time assessment and treatment, reducing discard rates and improving transplant success through dynamic oxygen and nutrient management.

JP2023514620A5Inactive Publication Date: 2026-07-01DEKA PRODUCTS LP

Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
DEKA PRODUCTS LP
Filing Date
2021-02-19
Publication Date
2026-07-01
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

The current methods for maintaining harvested kidneys for transplantation face challenges such as high rates of post-transplant organ dysfunction, sensitivity to cold-induced injury, and lower long-term transplant tissue survival rates, leading to a significant number of discarded organs due to flawed health assessment and logistical inefficiencies.

Method used

A normothermal renal perfusion system that maintains a pre-selected oxygen level in the perfusion fluid during transport, monitors organ health in real-time, and dynamically adjusts nutrient supply to ensure organ vitality, using sensors and perfusion devices to assess and optimize kidney health before transplantation.

Benefits of technology

The system extends preservation time, reduces organ discard rates, improves transplant success, and enables real-time diagnosis and treatment, enhancing patient health outcomes by optimizing kidney performance and limiting acute injury during transport.

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Abstract

A system and method for enabling sustained normothermic or subnormothermic perfusion of an organ and transport of the organ from a donor to a recipient. The system (100) includes a circulation system that provides oxygenated perfusate to the organ (135) and allows continuous monitoring of the perfusate moving through the organ. The tank (123) can provide an inlet that can receive a selected injectable substance and an outlet that can allow sampling and waste removal. The system can continuously monitor a solution bath in which the organ is immersed, and the system can manage the composition of the gas within the tank. A direct-acting pneumatic pump can be used to minimize hemolysis. The system can include a disposable portion and a durable portion.
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