System and method for predicting future lung cancer risk

JP2024525808A5Inactive Publication Date: 2025-03-19JOHNSON & JOHNSON ENTERPRISE INNOVATION INC
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Patent Information

Application Number
JP2024502086
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-04-07
Filing Date
2022-07-13
Publication Date
2025-03-19
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

Current lung cancer screening methods, such as the Lung-RADS scoring system, are inadequate for predicting long-term cancer risk and identifying patients at highest risk for future malignancy, limiting effective prevention strategies.

Method used

A risk prediction model that analyzes nodule-specific and non-nodule-specific features from CT scans, including lung parenchymal and body composition features, to predict future lung cancer risk, utilizing longitudinal data to monitor changes over time.

Benefits of technology

The model effectively predicts lung cancer risk, achieving an AUC value of at least 0.70 and odds ratio of at least 5.0, enabling early detection and targeted interventions for high-risk individuals.

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Abstract

The risk prediction models are trained and deployed to analyze images, such as computed tomography scans, to predict the risk of lung cancer (e.g., current or future risk of lung cancer) for one or more subjects. Individual risk prediction models are trained on nodule-specific and non-nodule-specific features, including longitudinal nodule-specific and longitudinal non-nodule-specific features, such that each risk prediction model can predict the risk of lung cancer over different time ranges. Such risk prediction models are useful for developing preventive therapies for lung cancer by enabling enrichment of clinical trials.
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