Continuous Cortisol Monitoring System with Microneedle Array

Abstract

Variations of cortisol monitoring systems are described herein, including cortisol monitoring devices. For example, the cortisol monitoring device may include a skin-penetrating microneedle array for use in measuring cortisol, such as in a continuous manner. The microneedle array may include at least one microneedle including a working electrode that includes a cortisol-sensing aptamer that selectively and reversibly binds to cortisol, for example. The microneedle array may include at least one microneedle including, for example, a tapered distal portion having an insulated distal tip and an electrode on a surface of the tapered distal portion disposed proximal to the insulated distal tip. At least a portion of the microneedle may be electrically insulated such that one or more electrodes are individually addressable.

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