Methods for increasing membrane selectivity

Abstract

The present disclosure relates to methods for improving the selectivity of membranes, particularly membranes comprising a blend of i) polysulfone, polyethersulfone, or polyarylethersulfone and ii) polyvinylpyrrolidone, characterized in that the membrane is coated with polydopamine and heparin in a one-step or two-step reaction, or by in situ modification with polydopamine followed by coating with heparin. The disclosure further relates to methods for producing such modified membranes with improved selectivity, and to filtration / diffusion devices comprising the membranes, which can be used, for example, in hemodialysis applications.

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