Identification of treatment target in aggressive nk leukemia

Abstract

To provide a method for suppressing the proliferation of tumor cells through identifying a molecule being a potential drug development target to knockdown or knockout it, as well as a screening method for tumor therapeutic drugs that target the identified molecule.SOLUTION: Provided according to the present invention is a method for suppressing the proliferation of tumor cells, including knockdown or knockout of the functions of at least one gene selected from the group consisting of genes that encode GGT1, IL-10R, CD16, RPM-1, and cysteine-related enzymes in tumor cells except for human treating methods. Also provided is a screening method for tumor therapeutic drugs, including: (i) bringing a candidate substance into contact with tumor cells; (ii) measuring the expression level of at least one gene selected from the group consisting of genes that encode GGT1, IL-10R, CD16, RPM-1, and cysteine-related enzymes in tumor cells, or measuring the expression level of a protein encoded by at least one of these genes; and (iii) selecting, as a therapeutic drug for the tumor, a candidate substance that has decreased the expression level as compared with the expression level without the candidate substance.SELECTED DRAWING: None