Device and program for measuring change in pupil diameter due to light stimulation and determining physical condition of subject

Abstract

To solve such a problem that the autonomic imbalance cannot be easily determined.SOLUTION: The present invention relates to a device for determining the brain disease or autonomic imbalance by utilizing the principle in which a brain activity is reflected in eyeball movement (changes in a pupil of an eye), showing a display screen whose brightness changes in a short time for a subject and analyzing the changes in the pupil diameter of the subject. The device is capable of simultaneously capturing left and right eyeball images using separate cameras when a high-brightness screen or low-brightness screen is displayed for the subject in a short time. The state of the change in the pupil in the brain disease state or autonomic imbalance state is fundamentally based on the findings that the state is different from that of a healthy person.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] This invention relates to a device that utilizes the principle that brain activity and autonomic nervous activity are expressed in changes in the eyes (pupils) to provide a light stimulus to a subject and analyze the movements of the subject's left and right eyes to determine whether the subject has a brain disease or an autonomic nervous system disorder. More specifically, this invention relates to a determination device that uses changes in the diameter of the subject's left and right pupils when the subject is shown independent images to the left and right eyes to determine whether the subject has a brain disease or an autonomic nervous system disorder. [Background technology]

[0002] The pamphlet for International Publication WO2017-057631 describes a subject emotion determination device. By using the device described in the above publication, it is possible to eliminate the influence of the subject's breathing, the influence of the brightness and darkness of the environment, the subject's pulse rate, etc., and to photograph the subject's pupils and determine the subject's emotions.

[0003] There was a need to develop a new device, such as the one described above, that could photograph the subject's pupils and a system for assessing the subject's physical condition. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] International Publication WO2017-057631 Brochure [Patent Document 2] PCT / JP2019 / 048894 [Patent Document 3] Patent application 2022-83400 Summary of the Invention [Problem to be solved by the invention]

[0005] The pamphlet for International Publication WO2017-057631 describes a device for determining the emotions of a subject. By using the device described in the above publication, it is possible to eliminate the effects of the subject's breathing, the effects of light and dark, and the subject's pulse rate, and to photograph the subject's pupils and determine the subject's emotions.

[0006] There was a desire to develop a system that could use a device like the one described above that could photograph the subject's pupil diameter and determine the subject's physical condition from the movement of the subject's eyeball by applying a light stimulus to the subject.

[0007] The purpose of this invention is to provide a new method for diagnosing a subject's brain disease or autonomic nervous system disorder by using a device that can capture images of the left and right eyes simultaneously with separate cameras to measure the change in pupil diameter of the subject when the subject is shown the same or different images displayed on the left and right simultaneously. [Means for solving the problem]

[0008] The present invention is basically based on the finding that when separate images are displayed on the left and right eyes of a subject, the change in pupil diameter of a subject suffering from poor physical condition due to brain disease or autonomic nervous system imbalance differs from that of a healthy person.

[0009] One of the aspects disclosed in this specification relates to a device for determining brain disease and autonomic nervous system imbalance. This brain disease / autonomic nervous system imbalance determining device 1 has a display image control unit 3, an eyeball photographing unit 5, and a determining unit . The display image control unit 3 is an element for changing the display image displayed on the video display unit 4 . The eyeball photographing unit 5 is an element for photographing an image of the eyeball of a subject viewing a displayed image. The judgment unit 7 is an element that uses the pattern of change over time in the size of the subject's pupil photographed by the eye photographing unit 5 or the movement of the viewpoint in the displayed image to determine whether the subject is suffering from a brain disease or is in poor physical condition due to autonomic nervous system dysfunction. This brain disease and autonomic nervous system imbalance diagnosis device 1 is, A display image control unit (3) changes the display image displayed on the video display unit (4) based on a pre-stored pattern. The eyeball photographing unit 5 simultaneously photographs, with separate cameras, images of the left and right eyes of the subject viewing the displayed image. The determination unit 7 receives an image including an image of the subject's eyeball captured by the eyeball photographing unit 5. The determination unit 7 then obtains the pattern of change over time in the size of the pupil of the subject photographed by the eyeball photographing unit 5 and the movement of the viewpoint, and uses the pattern of change over time to determine whether or not the subject is suffering from a brain disease or an autonomic nervous system imbalance.

[0010] The display pattern may vary, for example, in one or more of the following: brightness, color, and luminosity of the display for the left and right eyes of the subject, the perspective movement of a stereoscopic display image, and a maze image.Typical examples of display patterns are a white screen, which shows a bright screen to the subject for a short period of time (e.g., 1 second), or a black screen, which shows a dark screen to the subject for a short period of time (e.g., 4 seconds).

[0011] Examples of brain diseases are epilepsy, a neurodegenerative disease, a neural stem cell disease, a neural progenitor cell disease, an ischemic disease, a neurological trauma, an emotional disorder, a neuropsychiatric disease, a retinal degenerative disease, a retinal injury / trauma, a cognitive, learning or memory disorder, Alzheimer's disease, mild cognitive impairment (MCI), Parkinson's disease, Parkinson's syndrome, Huntington's disease, amyotrophic lateral sclerosis, ischemic stroke, a traumatic brain injury, depression, bipolar depression / disorder, chronic fatigue syndrome, anxiety syndrome / disorder, autism, or Asperger's syndrome. An example of autonomic nervous system imbalance is feeling unwell. Effect of the Invention

[0012] According to this invention, it is possible to provide a device that can determine whether a subject is suffering from a brain disease, whether the brain disease is severe, whether there is a high risk of suffering from the disease, and the severity of the autonomic nervous system disorder, simply by using a relatively simple device (for example, a device that can simultaneously capture images of the left and right eyes with separate cameras and simultaneously display the same or different images for the left and right). [Brief description of the drawings]

[0013] [Figure 1] Measuring instrument image [Diagram 2] Example of change in pupil diameter of subjects when they are shown a high brightness screen for a short period of time [Diagram 3] Change in brightness of the display screen for changing pupil diameter in Figure 2 [Figure 4] A model of pupil diameter change in subjects when a high-luminance image is displayed on a display screen for a short period of time [Diagram 5] Changes in pupil diameter and display screen brightness in Figure 4 [Figure 6] A model of pupil diameter change in subjects when a high-luminance image is displayed on a display screen for a short period of time [Figure 7] Change in display screen luminance in relation to pupil diameter change in Figure 6 [Figure 8] Example of deviation in pupil diameter between the left and right [Figure 9] Example of pupil diameter not matching between left and right DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0014] Hereinafter, an embodiment of the present invention will be described with reference to the drawings. The present invention is not limited to the forms described below, and also includes appropriate modifications of the forms below within the scope obvious to those skilled in the art. EXAMPLES

[0015] One of the aspects disclosed in this specification is autonomic nervous system dysfunction. Examples of autonomic nervous system imbalance include the determination of poor physical condition in transportation operators such as bus drivers, taxi drivers, large and long-distance truck drivers, train drivers, and aircraft pilots, as well as construction site managers and workers, and machine operators in factories, etc., who are not permitted to make any mistakes at all times due to occupational safety and health reasons.

[0016] Examples of brain diseases are epilepsy, a neurodegenerative disease, a neural stem cell disease, a neural progenitor cell disease, an ischemic disease, a neurological trauma, an emotional disorder, a neuropsychiatric disease, a retinal degenerative disease, a retinal injury / trauma, a cognitive, learning or memory disorder, Alzheimer's disease, mild cognitive impairment (MCI), Parkinson's disease, Parkinson's syndrome, Huntington's disease, amyotrophic lateral sclerosis, ischemic stroke, a traumatic brain injury, depression, bipolar depression / disorder, chronic fatigue syndrome, anxiety syndrome / disorder, autism, or Asperger's syndrome.

[0017] This brain disease / autonomic nervous system imbalance diagnosis device 1 has a display image control unit 3, an eyeball photographing unit 5, and a diagnosis unit 7. The display image control unit 3 is an element for changing the display image displayed on the video display unit 4 based on the display pattern. An example of the display unit is a monitor screen.

[0018] This device can be implemented by a computer that is capable of exchanging information with a photographing device such as a camera. The photographic information captured by a camera or the like may be input to a computer via a cable or the like. Furthermore, the photographic information may be input to a computer wirelessly. The computer includes an input / output unit, a control unit, a calculation unit, and a memory unit, and each element is capable of sending and receiving information via a bus or the like. The computer stores input information in the memory unit. The computer's control unit also reads out the control program stored in the memory unit, and causes the calculation unit to perform various calculations using the input information and the information stored in the memory unit. The calculation results are appropriately stored in the storage unit 11 and are also appropriately output via the input / output unit. The calculation results may be displayed on the analysis result display unit.

[0019] The display pattern may be one in which one or more of the following changes occur based on a predetermined time pattern: luminance, color, brightness, perspective changes in a stereoscopic image, a maze image, and a spot the difference image. A typical luminance change pattern is a high luminance image for a short period of time (for example, 1 second).

[0020] When a screen with varying luminance as shown in FIG. 3 is displayed to a subject on the image display unit 4 shown in FIG. 1, the pupil diameter of the subject changes as shown in FIG. Healthy subjects show the same change in pupil diameter in both eyes. The initial low-brightness screen is displayed on the video display unit 4 at the lowest brightness (e.g., “0” (nt)) until the pupil diameter stabilizes (e.g., 10 seconds or more), and the pupil diameter of the subject at this time becomes the maximum pupil diameter when looking at this display screen. The subject is then shown a high-intensity (e.g., "100" (nt)) screen for a short period of time (e.g., 1 second). The subject's pupils then begin to constrict after a delay. When the short high-luminance screen ends and the display screen returns to luminance "0" (nt), the pupil diameter continues to contract for a while, and then expands again. At that point, the pupil diameter expands as the pupil adapts to dark, but generally, the pupil diameter moves slower when the pupil adapts to dark screens than when the pupil adapts to light when the pupil adapts to a bright screen, so the pupil diameter shows a gradual expansion curve. After a few seconds (e.g. 8 seconds), if the subject is shown a display screen with the same luminance as the first short-term high-luminance screen again for a period of time until the subject's pupil diameter stabilizes (e.g. 10 seconds or more), the pupil diameter will show its original pupil diameter when viewed on a high-luminance screen.

[0021] Figure 4 shows a model of this change in pupil diameter. Based on this figure, the change in pupil diameter can be explained as follows: When a screen with luminance changes as shown in FIG. 5 is shown to a subject on the image display unit 4 shown in FIG. 1, the subject will exhibit the change in pupil diameter shown in FIG. 4, which is a model of the actual example in FIG. The first low brightness screen is the lowest brightness of the display screen. At this time, the time until the pupil diameter stabilizes (for example, 10 seconds or more) is displayed. The pupil diameter at this time is the maximum pupil diameter "h" when viewing this screen. After that, the subject is shown a high-brightness screen for a short period of time (e.g., 1 second) from time t1 to time t3. The subject's pupil diameter then begins to contract with a delay, and the time at which this delay is determined is designated "t2." Time t2 is the time when it is determined that the pupil diameter contraction has started, and is the time when the pupil diameter contraction amount is, for example, 10% above "L". Even after the short period of time (t1 to t3) of high-brightness screen ends and the displayed image returns to the initial low-brightness screen, the pupil diameter continues to contract for a while, reaching its minimum at some point (time t5), and then the pupil diameter expands again. At that time, the pupil moves to adapt to the dark, but generally the pupil diameter moves slower in dark adaptation than in light adaptation, so the pupil diameter shows a gentle, mountain-shaped expansion curve. After a few seconds (e.g., 6 seconds), the subject is shown a display screen with the same brightness as the initial short period of high brightness for a period of time to allow the subject's pupil diameter to stabilize (e.g., 10 seconds or more), at which point the subject's pupil diameter will show its original value, "r," when viewed on the high-brightness screen.

[0022] When a high-luminance screen is displayed to a healthy subject, the time "E" from the start of the high-luminance screen display (t1) to the time t2 at which it is determined that the pupil diameter has started to contract is short. E-(t2-t1) The contraction speed "A" of the pupil diameter is calculated based on the pupil diameter "i" at the pupil contraction start determination point 403 (for example, 10% from the top of the pupil diameter contraction amount "L"), the pupil diameter "k" at the pupil diameter contraction end determination point (404) (for example, 90% from the top of the pupil diameter contraction amount "L"), and the change amount "I" up to time t4. I = ik, That time "F" is F=t4-t2 The contraction speed "A" is

[0023]

number

[0024] The pupil diameter re-expansion start decision point 405 is also set to the 90% point from the top of the pupil diameter re-expansion amount "M", the time is t6, and the pupil diameter is s. However, the action of pupil re-expansion is slow because of dark adaptation, there is no straight line portion as in the case of contraction, and it takes time for the pupil diameter to reach the initial pupil diameter "h", so for example, point 406 of the pupil diameter at the midpoint "m" of the 50% point of the pupil diameter re-expansion amount M is set as the pupil diameter re-expansion judgment point. Also, the time is set as t7. This means: The pupil diameter re-expansion judgment amount J is J=ms The expansion judgment time H is H=t7-t6 Therefore, the speed of pupil re-expansion "B" is

[0025]

number

[0026] The maximum change in pupil diameter of the subject, “K”, is K=hr It is. The ratio "U" of the pupil diameter change contraction judgment amount "I" (=ik) to the subject's maximum pupil diameter change amount "K" due to a short-term high-luminance screen is U=I / K It is.

[0027] If the same low-luminance screen is displayed again from t3 to t8 (for example, 6 seconds), the pupil diameter expands again, but even after the low-luminance screen display ends at t8, the pupil diameter continues to expand, peaking at a delayed time t9, and the pupil diameter becomes n. The amount of this pupil diameter expansion "N" is the same as n. The ratio U2 of this pupil diameter re-expansion amount N to the subject's maximum pupil diameter change amount "K" is U2=N / K It becomes.

[0028] Furthermore, the display screen returns to the same low luminance screen as the beginning at time "t3", and the pupil diameter continues to shrink even after passing time t4, the pupil diameter contraction end determination point (404). The pupil diameter bottoms out at t5 and expands again, but the time G until the re-expansion determination point at time "t6" can also be a yardstick for determining the state of autonomic nervous system imbalance. (T3 and t4 may be earlier or later depending on the machine and the subject.) G=t6-t4

[0029] From the above A: Pupil diameter contraction speed B: Pupil re-expansion rate U: The ratio of the pupil diameter contraction judgment amount "I" due to a short-term high-luminance screen to the subject's maximum pupil diameter change amount "K" U2: The ratio of pupil diameter re-expansion amount N to the subject's maximum pupil diameter change amount "K" When the subject differs from healthy people of the same age, or E: The time from the start of the high-luminance screen to the start of pupil contraction (latency) G: The time from when the pupil diameter passes the contraction judgment point 404 after the high-luminance screen display ends until the pupil diameter re-expansion judgment point 405 after the first low-luminance screen starts (t6-t4) When the subject differs from healthy subjects of the same age It can be determined that the patient is in a state of mental illness or that the autonomic nervous system is in a state of imbalance.

[0030] On the other hand, there may be a method for determining whether a subject has a brain disease or an autonomic nervous system disorder based on the pupil diameter of the subject when the subject is shown a low-luminance screen for a short period of time. A model of the change in pupil diameter of the subject due to changes in luminance on the display screen in FIG. 7 is shown in FIG. Based on this figure, the change in pupil diameter can be explained as follows:

[0031] It is assumed that when a display screen showing luminance changes as shown in FIG. 7 is shown to a subject on the image display unit 4 shown in FIG. 1, the pupil diameter of the subject shows the changes shown in FIG. The first low-brightness screen is displayed until the pupil diameter stabilizes (for example, for 10 seconds or more). The pupil diameter at this time is the maximum pupil diameter "h" when viewing this image display. After that, from time (t10), a high-luminance screen is displayed, and the pupil diameter of the subject is displayed for a time period (e.g., 10 seconds or more) until the pupil diameter stabilizes while looking at the high-luminance screen. At this time, the pupil diameter of the subject becomes the minimum pupil diameter "r" on this display screen. After that, a low-luminance screen is displayed for a short period of time (eg, 4 seconds) from time t13 to t16. The subject's pupil diameter begins to dilate with a delay, but even when the display screen becomes high-luminance at time "t16", the pupil diameter continues to dilate for a while, reaching a peak value of "o" at time t17, and then contracting.

[0032] In a healthy person, the time "V" from when the high-luminance screen starts to be displayed (t10) to when it is determined that the pupil diameter has started to contract (t11) is shorter than that of a person with a brain disease or autonomic nervous system disorder. V = (t11-t10) The change in pupil diameter speed "C" from pupil diameter "e" at pupil contraction start determination point 603 (for example, 10% from the top of pupil diameter contraction amount "Q" (=hr)) to pupil diameter "x" at pupil contraction end determination point (604) (for example, 90% from the top of pupil diameter contraction amount "Q") is R=ex, The contraction time N2 is N2=t12-t11 Therefore, the pupil diameter contraction speed "C" is

[0033]

number

[0034] From the relationship between the pupil diameter value “q” at the pupil diameter re-expansion decision point (for example, 90% from the top of the pupil diameter expansion amount “S”) 605 and its time “t14”, and the pupil diameter “p” at the midpoint of pupil diameter expansion (50% of the pupil diameter expansion amount S) 606 and its time t15, Pupil dilation delay time "O" is O=t14-t13 Pupil diameter dilation judgment time P is P=t15-t14 The pupil diameter dilation judgment amount "W" is W=pq Therefore, the pupil re-expansion speed "D" is D=W / P It becomes.

[0035] The ratio "Y" of the pupil diameter re-expansion amount "S" to the maximum pupil diameter change amount "Q" is Y=S / Q It becomes.

[0036] The midpoint of pupil dilation was used as the standard for the pupil dilation speed because at this time the subject's pupil diameter indicates dark adaptation, but the pupil diameter in dark adaptation shows a mountain-shaped change curve, so the midpoint 606, which is easy to judge, was used as the standard and the judgment point for pupil dilation.

[0037] From the above, the subjects' average scores were compared with those of healthy subjects of the same age. C: Pupil diameter contraction speed D: Pupil re-expansion rate Y (ratio of pupil dilation to maximum pupil change) When are different, or V: Time from the start of the high-luminance screen to the start of pupil contraction (latency) O: Pupil re-expansion delay time (time from when the low-brightness screen starts until when pupil re-expansion is determined to start) When the subject differs from healthy subjects of the same age The subject can be determined to be in a brain disease state or in a state of autonomic nervous system imbalance.

[0038] In addition, in a healthy person, the movement of the pupil diameter of the left and right eyes when a high-brightness screen is displayed for a short period of time is almost the same. However, if there is a discrepancy in the movement of the pupil diameter between the left and right eyes, as in Figure 8, or if the changes in pupil diameter between the left and right eyes are not synchronized, as in Figure 9, this can also be judged to be a state of brain disease or autonomic nervous system imbalance. [Industrial Applicability]

[0039] According to this invention, a device can be provided that can determine whether a subject is suffering from a brain disease, whether the brain disease is severe, whether there is a high risk of suffering from the disease, and the degree of autonomic nervous system dysfunction, simply by using a relatively simple device (for example, a device that can simultaneously capture images of the left and right eyes with separate cameras and simultaneously display the same or different images for the left and right). Examples of brain diseases are epilepsy, a neurodegenerative disease, a neural stem cell disease, a neural progenitor cell disease, an ischemic disease, a neurological trauma, an emotional disorder, a neuropsychiatric disease, a retinal degenerative disease, a retinal injury / trauma, a cognitive, learning or memory disorder, Alzheimer's disease, mild cognitive impairment (MCI), Parkinson's disease, Parkinson's syndrome, Huntington's disease, amyotrophic lateral sclerosis, ischemic stroke, a traumatic brain injury, depression, bipolar depression / disorder, chronic fatigue syndrome, anxiety syndrome / disorder, autism, or Asperger's syndrome. An example of an industrial application of the autonomic nervous system disorder diagnosis is the diagnosis of poor physical condition in transportation operators such as bus drivers, taxi drivers, large and long-distance truck drivers, train drivers, and aircraft pilots, as well as construction site managers and workers, and machine operators in factories, etc., who are in jobs where incorrect behavior is not permitted due to occupational safety and health reasons. [Explanation of symbols]

[0040] 1 Diagnostic equipment 2 Eyepiece 3. Display image control section 4. Video display section 5 Eyeball Photography Department 6 Measuring instrument control section 7 Judgment section 8. Luminance Meter 9 Arithmetic section 10 Analysis result display section 11 Storage section 400 Changes in pupil diameter when a high-brightness screen is displayed for a short period of time 401 Vertical axis: Pupil diameter (mm) 402 Horizontal axis: Elapsed time 403 Pupil contraction start judgment point (for example, 10% from the top of the pupil diameter change amount) 404 Pupil contraction end judgment point (for example, 90% from the top of the pupil diameter change amount) 405 Pupil re-expansion start decision point 406 The point where the pupil diameter re-expansion amount M becomes 50% 407 Pupil Diameter Change Curve h Pupil diameter of the subject when viewing a low-luminance screen before viewing a high-luminance screen i Pupil diameter contraction start judgment value (for example, 10% point from the top of "pupil diameter contraction amount L") j Minimum pupil diameter when pupil is constricted k Pupil diameter contraction end judgment value (for example, the top 90% point of pupil diameter contraction amount "L") r Minimum pupil diameter (pupil diameter under luminance equivalent to a high-luminance screen) m Pupil re-expansion midpoint (50% of pupil re-expansion amount "M") n Re-expanded pupil diameter s Pupil re-expansion start judgment value (the value from the top 90% of the pupil re-expansion amount "M") A. Subject's pupil diameter contraction speed B. Pupil re-expansion rate of the subject E. The time from the start of the high-brightness screen display to the start of pupil contraction (latency) F Pupil diameter contraction judgment time (= t4 - t2) G Time from pupil contraction judgment point to pupil re-expansion judgment point (= t6 - t4) H Pupil diameter expansion judgment time (t7-t6) I. Change in pupil diameter when the subject's pupil diameter contracts J Pupil diameter re-enlargement judgment amount K Maximum change in pupil diameter of subject L Pupil diameter contraction amount M Pupil re-expansion amount N The amount of pupil diameter re-expansion from the pupil diameter “r” when the last high-brightness screen was displayed (=n) U The ratio of the pupil diameter change amount "I" caused by a short-term high-luminance screen to the maximum pupil diameter change amount "K" of the subject U2 Ratio of pupil re-expansion amount N to the subject's maximum pupil diameter change amount "K" t1 High brightness screen display start time t2 Pupil diameter contraction start judgement time t3 When high-brightness screen display ends t4 Pupil diameter contraction end determination t5 End of pupil contraction t6 The point at which the pupil diameter re-expansion amount "M" reaches, for example, 90% t7 Midpoint of pupil re-expansion (e.g. 50% from pupil re-expansion amount “M”) t8 When the low brightness screen ends again t9 Maximum pupil re-expansion 600 Changes in pupil diameter when a low-luminance screen is displayed for a short period of time 601 Vertical axis: Pupil diameter (mm) 602 Horizontal axis: Elapsed time 603 Pupil contraction start judgment point (for example, 10% from the top of the pupil diameter change amount Q) 604 Pupil diameter contraction end judgment point (for example, 90% from the top of the pupil diameter change amount Q) 605 Pupil re-expansion start decision point 606 50% of pupil diameter re-expansion 607 Pupil Diameter Change Curve e Pupil diameter contraction amount start judgment value (for example, the top 10% point of "pupil diameter contraction amount Q") h Pupil diameter of the subject when viewing a low-luminance screen before viewing a high-luminance screen p Pupil re-expansion midpoint (50% of pupil re-expansion amount “S”) q Pupil re-expansion judgment value (90% from the top of pupil re-expansion amount "S") r Minimum pupil diameter when pupil is constricted x Pupil diameter contraction end judgment value (for example, the top 90% point of pupil diameter contraction amount "Q") C. Subject's pupil diameter contraction speed D. Pupil re-expansion rate of the subject V Time from the high-brightness screen display "t10" to pupil diameter contraction judgment (latency) (=t11-t10) N2 Pupil diameter contraction time (=t12-t11) O Time from the start of low-luminance display to the determination of pupil re-dilation (latency) (=t14-t13) P Pupil diameter re-expansion judgment time (50% point of pupil diameter expansion amount S) (= t15 - t14) Q Maximum pupil diameter change R Pupil diameter contraction judgment amount (=ex) S Pupil Diameter Expansion Amount (=or) W pupil diameter dilation judgment amount (=pq) Y Ratio of pupil dilation to maximum pupil change t10 High brightness screen display start time t11 Pupil diameter contraction start detection t12 Pupil diameter contraction end determination t13 Low brightness screen display start time t14 When pupil dilation starts (when pupil dilation value "S" reaches, for example, 90%) t15 When pupil diameter expansion is judged (when pupil diameter expansion value becomes, for example, 50% from "S") t16 High brightness screen display start time t17 Peak pupil dilation

Claims

1. A display image control unit that changes the same or different display images displayed on the display units for the left and right eyes of the subject; an eyeball photographing unit that photographs the left and right eyeball images of a subject viewing the display image simultaneously using separate independent cameras; In the pattern of change over time in the size of the pupils of the left and right eyes of the subject photographed by the eyeball photographing unit, A device and program for determining whether a subject is in a state of mental illness or in a state of autonomic nervous system imbalance based on the degree to which the change in pupil diameter of the subject deviates from the average for healthy subjects, using a display pattern that displays a high-brightness screen for a short period of time and then a low-brightness screen.

2. The apparatus for determining a brain disease state and an autonomic nervous system imbalance state according to claim 1, First, a low-luminance display screen is displayed to the left and right eyes of the subject for a period of time until the pupil diameter stabilizes, and then a high-luminance screen is displayed for a short period of time (for example, 1 second). When the pupil diameter contraction speed, pupil diameter re-expansion speed, the ratio of the pupil diameter contraction judgment amount due to the short-time high-luminance screen to the maximum change in the subject's pupil diameter, the ratio of the pupil diameter re-expansion amount to the maximum change in the subject's pupil diameter, etc. differ from those of healthy people of the same age as the subject, Alternatively, when the time (latency) from the start of a high-brightness screen to the start of pupil diameter contraction determination, the time from the end of the high-brightness screen display to the point of determining that the pupil diameter has expanded again, etc., differs from that of a healthy person of the same age as the subject, the device and program for determining that the subject is in a afflicted disease state, or that the subject is in a afflicted disease state and in a state of autonomic nervous system imbalance. An apparatus and program for determining autonomic nervous system imbalance.

3. The apparatus for determining a brain disease state and an autonomic nervous system imbalance state according to claim 1, When a low-luminance screen was displayed briefly to each of the subjects' eyes First, a low-luminance display screen is displayed to the left and right eyes of the subject for the time it takes for the pupil diameter to stabilize, and then a high-luminance screen is displayed for the time it takes for the pupil diameter to stabilize. When the low-luminance screen is displayed for a short period of time (for example, 4 seconds), the pupil diameter contraction speed, pupil diameter re-expansion speed, and ratio of pupil diameter change to pupil diameter re-expansion amount, etc., differ from those of healthy subjects of the same age. Or, the time from the start of the high-luminance screen to the start of pupil contraction (latency), the time from the end of the high-luminance screen to the start of the low-luminance screen to the time of pupil re-expansion determination, etc. A device and program for determining whether a subject is in a state of illness or autonomic nervous system imbalance when the subject's condition differs from that of healthy people of the same age.

4. The apparatus for determining a brain disease state and an autonomic nervous system imbalance state according to claim 1, In a healthy subject, the movement of the pupil diameter of the left and right eyes when a high-brightness screen is displayed for a short period of time or a low-brightness screen is displayed for a short period of time is almost the same, but if there is a discrepancy in the movement of the pupil diameter between the left and right eyes or if the changes in the pupil diameter between the left and right eyes are not synchronized, the subject is determined to have autonomic nervous system disorder.

5. The diagnostic device for brain disease state / autonomic nervous system imbalance state according to claim 1, Examples of brain diseases are epilepsy, neurodegenerative diseases, neural stem cell diseases, neural progenitor cell diseases, ischemic diseases, neurological trauma, emotional disorders, neuropsychiatric diseases, retinal degenerative diseases, retinal damage / trauma, cognitive, learning and memory disorders, Alzheimer's disease, mild cognitive impairment (MCI), Parkinson's disease, Parkinson's syndrome, Huntington's disease, amyotrophic lateral sclerosis, ischemic stroke, traumatic brain injury, depression, bipolar depression / disorder, chronic fatigue syndrome, anxiety syndrome / disorder, autism, or Asperger's syndrome. Autonomic nervous system dysfunction is a sign of poor health.

6. An apparatus and program that enables more detailed and accurate determination of the type of brain disease state or autonomic nervous system disorder state through AI learning of examples of the patterns displayed on the subject's screen and the change patterns of pupil diameter in the left and right of the subject.

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