Methods for controlling progression of hyperparathyroidism with calcifediol and compositions for use therein

Abstract

To provide methods and compositions for regulating hyperparathyroidism.SOLUTION: One aspect of the disclosure is a method for preventing, halting or reversing the SHPT progression in a subject, e.g., a human adult, defined as an increase in iPTH by >10% from the pretreatment baseline, the method comprising effective administration of 25-hydroxyvitamin D to increase and maintain serum total 25-hydroxyvitamin D in the patient to a concentration greater than 50 ng / mL, optionally at least 50.8 ng / mL, optionally at least 51 ng / mL or at least 60 ng / mL, and thereby preventing, halting, or reversing SHPT progression in the patient.SELECTED DRAWING: None

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