Cleansing agent for oral appliances in tablet form

Abstract

To provide a cleansing agent for oral appliances in tablet form that prevents sticking during the tableting process while comprising at least one selected from the group consisting of isopropyl methyl phenol and its structural isomers, or menthol.SOLUTION: A cleansing agent for oral appliances in tablet form according to the present disclosure comprises (A) at least one selected from the group consisting of isopropyl methyl phenol and its structural isomers, or (B) menthol, and (C) at least one selected from the group consisting of malic acid and its salts.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present disclosure relates to an oral instrument cleanser for tablets that can suppress the occurrence of sticking during tablet compression. [Background technology]

[0002] Stains that adhere to intraoral appliances such as dentures include food residues, denture biofilms, tartar-like deposits, pigments, etc. Here, denture biofilms are biofilms in which oral microorganisms settle on the surface of intraoral appliances and aggregate with products such as adhesive polysaccharides, saliva, serum components, etc. Because various microorganisms exist in denture biofilms, they can cause denture stomatitis, bad breath, and denture odor, or in the case of partial dentures, can easily cause cavities and periodontal disease in remaining teeth.

[0003] It has been pointed out that denture biofilms can promote or induce periodontal disease, denture stomatitis, candidiasis, aspiration pneumonia, etc., and therefore it is important for users of intraoral appliances to maintain their health by removing denture biofilms that have adhered to them and keeping them clean.

[0004] Since denture biofilms attached to intraoral instruments cannot be sufficiently removed by cleaning with a brush, cleaning with an intraoral instrument cleaner that has a germ-killing effect is important. Various intraoral instrument cleaners that have a germ-killing or bactericidal effect have been investigated.

[0005] For example, Patent Document 1 describes that the bactericidal activity against denture biofilms can be further enhanced by blending (E) isopropylmethylphenol and / or thymol with a denture cleansing liquid composition containing (A) a polyglycerol fatty acid ester having an HLB value of 12 to 17, (B) a protease, (C) a cationic bactericide, and (D) water.

[0006] Furthermore, in order to reduce the odor of the intraoral appliance and to make the wearer feel refreshed when reinserting the intraoral appliance after cleaning, a fragrance such as menthol may be blended into the intraoral appliance cleanser (see, for example, Patent Document 2). [Prior art documents] [Patent documents]

[0007] [Patent Document 1] JP 2010-6720 A [Patent Document 2] JP 2011-241167 A Summary of the Invention [Problem to be solved by the invention]

[0008] However, it has been found that when isopropylmethylphenol or thymol is added to an oral instrument cleanser to impart a disinfecting or bactericidal effect, or when menthol is added as a fragrance, the bonding strength between the components in the tablet decreases during tableting of the oral instrument cleanser, making the tablet more susceptible to sticking (a phenomenon in which part of the raw materials adheres to the punch or die, causing part of the tablet to peel off).

[0009] An object of the present disclosure is to provide an intraoral instrument cleanser for tablets that contains at least one selected from the group consisting of isopropylmethylphenol and its structural isomers, or menthol, and yet can suppress the occurrence of sticking during tableting. [Means for solving the problem]

[0010] The present inventors have conducted intensive research to solve the above problems, and have unexpectedly found that the occurrence of sticking during tableting can be suppressed by further blending at least one selected from the group consisting of malic acid and its salts with an intraoral instrument cleanser containing at least one selected from the group consisting of isopropylmethylphenol and its structural isomers, or menthol. The present disclosure has been completed based on this finding and through further research.

[0011] That is, the present disclosure provides the inventions of the following aspects. Item 1. A cleanser for an oral instrument for tablets, comprising (A) at least one selected from the group consisting of isopropylmethylphenol and structural isomers thereof, or (B) menthol, and (C) at least one selected from the group consisting of malic acid and salts thereof. Item 2. The oral cavity instrument cleanser for tablets according to Item 1, wherein the structural isomer is thymol. Item 3. The oral cavity instrument cleanser for tablets according to Item 1 or 2, which is a denture cleanser. Item 4. A method for producing a tablet-shaped intraoral instrument cleanser, comprising subjecting a raw material mixture containing (A) at least one selected from the group consisting of isopropylmethylphenol and structural isomers thereof, or (B) menthol, and (C) at least one selected from the group consisting of malic acid and salts thereof, to a tableting step. Item 5. Use of a composition comprising (A) at least one selected from the group consisting of isopropylmethylphenol and structural isomers thereof, or (B) menthol, and (C) at least one selected from the group consisting of malic acid and salts thereof, for cleaning an intraoral appliance. Item 6. Use of a composition comprising (A) at least one member selected from the group consisting of isopropylmethylphenol and structural isomers thereof, or (B) menthol, and (C) at least one member selected from the group consisting of malic acid and salts thereof, as an intraoral instrument cleanser for tablets. Item 7. A method for cleaning an intraoral instrument, comprising immersing an intraoral instrument in water containing a tablet-shaped intraoral instrument cleanser comprising (A) at least one member selected from the group consisting of isopropylmethylphenol and structural isomers thereof, or (B) menthol and (C) at least one member selected from the group consisting of malic acid and salts thereof. Effect of the Invention

[0012] The intra-oral instrument cleanser for tablets disclosed herein contains at least one selected from the group consisting of isopropylmethylphenol and its structural isomers, or menthol, and further contains at least one selected from the group consisting of malic acid and its salts. This makes it possible to suppress sticking during tableting and reduce production losses in the tableting process, thereby achieving high production efficiency in industrial production. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0013] In this specification, the notation X to Y regarding a numerical range means that the range is from X to Y.

[0014] In this specification, the term "oral appliance" refers to a dental appliance that needs to be worn and removed in the oral cavity, such as a complete denture, a partial denture, an orthodontic appliance, a retainer, and a mouthpiece.

[0015] 1. Mouthpiece cleaner for tablets The intraoral instrument cleaner for tablets of the present disclosure (hereinafter, also simply referred to as "intraoral instrument cleaner") is characterized by containing (A) at least one selected from the group consisting of isopropylmethylphenol and its structural isomers (hereinafter, sometimes referred to as (A) component), or (B) menthol (hereinafter, sometimes referred to as (B) component), and (C) at least one selected from the group consisting of malic acid and its salts (hereinafter, sometimes referred to as (C) component). The intraoral instrument cleaner of the present disclosure will be described in detail below.

[0016] [(A) Isopropylmethylphenol and its structural isomers] In the intraoral instrument cleaner of the present disclosure, component (A) is a component for imparting a disinfecting or bactericidal effect to the intraoral instrument cleaner. In this specification, "isopropylmethylphenol" means "4-isopropyl-3-methylphenol". The structural isomer of isopropylmethylphenol is not particularly limited as long as it is pharmacologic acceptable, and examples thereof include thymol and carvacrol, and from the viewpoint of imparting an excellent disinfecting or bactericidal effect to the intraoral instrument cleaner, thymol is preferred.

[0017] When the intra-oral instrument cleanser of the present disclosure contains component (A), the content of component (A) may be appropriately set within a range in which the desired disinfecting or bactericidal effect is obtained, for example, 0.001 to 10% by weight, and from the viewpoint of improving the disinfecting or bactericidal effect of the intra-oral instrument cleanser, the content is preferably 0.01 to 5% by weight, more preferably 0.03 to 1% by weight, and even more preferably 0.05 to 0.5% by weight.

[0018] [(B) Menthol] In the intraoral instrument cleanser of the present disclosure, component (B) is a component that imparts a fragrance to the intraoral instrument after cleaning. By incorporating menthol into the intraoral instrument cleanser, a refreshing feeling can be imparted to the wearer's mouth when wearing the cleaned intraoral instrument, and the cleaning effect can be realized.

[0019] Menthol may be any of d-, l-, and dl-forms, but is preferably l-menthol. Menthol may also be used in the form of essential oil. Essential oils containing menthol are not particularly limited, but include, for example, spearmint oil, peppermint oil, peppermint oil, and peppermint white oil. The menthol and essential oils exemplified above may be used alone or in combination of two or more.

[0020] In the intra-oral instrument cleanser of the present disclosure, the content of component (B) (the content converted to the amount of menthol when an essential oil is used) may be appropriately set within a range that can impart the desired fragrance to the intra-oral instrument after cleaning, and is, for example, 0.001 to 10% by weight, and from the viewpoint of imparting a sufficient fragrance to the intra-oral instrument after cleaning, is preferably 0.01 to 5% by weight, more preferably 0.03 to 1% by weight, and even more preferably 0.05 to 0.5% by weight.

[0021] [(C) Malic acid and its salts] The intraoral instrument cleaner of the present disclosure contains at least one selected from the group consisting of malic acid and its salts as component (C). Examples of the salt include alkali metal salts such as sodium salts and potassium salts, and ammonium salts. An intraoral instrument cleaner containing component (A) or component (B) has a drawback that sticking is likely to occur during tableting, but the intraoral instrument cleaner of the present disclosure overcomes the drawback by including component (C) and can suppress the occurrence of sticking during tableting. In addition, when the intraoral instrument cleaner of the present disclosure contains a carbonate compound described below, component (C) becomes a constituent of the foaming agent and plays a role of reacting with the carbonate compound to generate carbon dioxide gas during cleaning of an intraoral instrument.

[0022] In the intra-oral instrument cleanser of the present disclosure, the content of component (C) may be appropriately set within a range that can suppress the occurrence of sticking during tableting, for example, 0.01 to 10% by weight, and from the viewpoint of more effectively suppressing the occurrence of sticking during tableting, the content is preferably 0.05 to 5% by weight, more preferably 0.1 to 3% by weight, and even more preferably 0.5 to 2% by weight.

[0023] In the intra-oral instrument cleanser of the present disclosure, the content ratio of component (C) to component (A) is not particularly limited, and the content of component (C) per 1 part by weight of component (A) is, for example, 0.1 to 50 parts by weight. From the viewpoint of more effectively suppressing the occurrence of sticking during tableting, the content is preferably 1 to 40 parts by weight, more preferably 2 to 30 parts by weight, and even more preferably 3 to 20 parts by weight.

[0024] In the intra-oral instrument cleanser of the present disclosure, the content ratio of component (C) to component (B) is not particularly limited, and the content of component (C) per 1 part by weight of component (B) is, for example, 0.1 to 50 parts by weight. From the viewpoint of more effectively suppressing the occurrence of sticking during tableting, the content is preferably 1 to 40 parts by weight, more preferably 2 to 30 parts by weight, and even more preferably 3 to 20 parts by weight.

[0025] [Other ingredients] In addition to the components described above, the intra-oral instrument cleanser of the present disclosure may contain other components as necessary to the extent that the effects of the present disclosure are not impaired.

[0026] (foaming agent) The intra-oral instrument cleaner of the present disclosure preferably contains a foaming agent. When the intra-oral instrument cleaner of the present disclosure contains a foaming agent, carbon dioxide bubbles can be generated in the cleaning water, and physical cleaning power due to the foaming action can be exerted, thereby effectively removing dirt from the intra-oral instrument.

[0027] There are no particular limitations on the type of foaming agent, so long as it is non-toxic and physiologically acceptable, and a wide range of foaming agents commonly used in intraoral instrument cleaners (i.e., those capable of generating carbon dioxide in water) can be used.

[0028] Examples of the foaming agent include a combination of at least one of carbonate, bicarbonate, and a double salt of bicarbonate and carbonate (hereinafter, sometimes referred to as a carbonate compound) and an acid. Examples of carbonates include, but are not limited to, alkali metal salts of carbonic acid such as sodium carbonate and potassium carbonate. Examples of bicarbonates include, but are not limited to, alkali metal salts of bicarbonate such as sodium bicarbonate and potassium bicarbonate. Examples of double salts of carbonate and bicarbonate include, but are not limited to, sodium sesquicarbonate. The carbonate compounds may be used alone or in combination of two or more. Examples of acids other than malic acid include, but are not limited to, organic acids such as citric acid, tartaric acid, fumaric acid, maleic acid, gluconic acid, succinic acid, salicylic acid, and the like; inorganic acids such as phosphoric acid and sulfamic acid, and the like. The acids may be used alone or in combination of two or more.

[0029] The carbonate compound constituting the foaming agent is preferably an alkali metal salt of hydrogen carbonate and an alkali metal salt of carbonic acid, more preferably sodium hydrogen carbonate and sodium carbonate, and the acid constituting the foaming agent is preferably an organic acid, more preferably citric acid.

[0030] In the foaming agent, the ratio of the carbonate compound to the acid is not particularly limited as long as the two can react in water to generate carbon dioxide. The content of the acid (including malic acid) per 100 parts by weight of the carbonate compound is, for example, 10 to 200 parts by weight, preferably 15 to 150 parts by weight, and more preferably 20 to 100 parts by weight.

[0031] When the intra-oral instrument cleansing agent of the present disclosure contains a foaming agent, the content of the foaming agent (total amount of carbonate compound and acid (including malic acid)) is not particularly limited as long as sufficient carbon dioxide bubbles can be generated when cleaning intra-oral instruments, and can be, for example, 10 to 75% by weight, preferably 20 to 70% by weight, and more preferably 30 to 65% by weight.

[0032] (Bleach) The intra-oral instrument cleanser of the present disclosure preferably contains a bleaching agent, which can improve cleaning power.

[0033] The type of bleach used in the intraoral instrument cleanser of the present disclosure is not particularly limited as long as it is non-toxic and physiologically acceptable, and any bleach commonly used in intraoral instrument cleansers can be used.

[0034] Bleaching agents include, for example, oxygen-based bleaching agents such as monopersulfates, perborates, percarbonates, and persulfates.

[0035] Specific examples of the monopersulfate include alkali metal salts of monopersulfate such as sodium monopersulfate and potassium monopersulfate (bis(peroxymonosulfate)·bis(sulfate)·pentapotassium, etc.), ammonium monopersulfate, and hydrates thereof. Specific examples of the perborate include alkali metal salts of perboric acid such as sodium perborate and potassium perborate, ammonium perborate, and hydrates thereof. Specific examples of the percarbonate include alkali metal salts of percarbonate such as sodium percarbonate and potassium percarbonate, ammonium percarbonate, and hydrates thereof. Specific examples of the persulfate include alkali metal salts of persulfate such as sodium persulfate and potassium persulfate, ammonium persulfate, and hydrates thereof. The bleaching agents exemplified above may be used alone or in combination of two or more. Among the bleaching agents exemplified above, preferred are hydrogen monopersulfates, perborates, and percarbonates, more preferred are alkali metal salts of hydrogen monopersulfates, alkali metal salts of perboric acid, and alkali metal salts of percarbonate, and even more preferred are potassium hydrogen monopersulfate, sodium perborate, and sodium percarbonate.

[0036] In the intra-oral instrument cleanser of the present disclosure, the content of the bleaching agent may be appropriately set within a range that can exert the desired bleaching effect, and may be, for example, 1 to 40% by weight, preferably 5 to 35% by weight, and more preferably 10 to 30% by weight.

[0037] (bleach activator) When the intraoral instrument cleaner of the present disclosure contains an oxygen bleaching agent, it may contain a bleaching activator. The bleaching activator is HO2 generated from the oxygen bleaching agent in water. - It reacts with and produces organic peracids with a more effective bleaching effect.

[0038] The bleaching activator may be any known one without any particular limitation, and examples thereof include tetraacetylethylenediamine; alkanoyloxybenzenesulfonic acid or its salt having an alkanoyl group having 1 to 18 carbon atoms, preferably 8 to 12 carbon atoms; alkanoyloxybenzoic acid or its salt having an alkanoyl group having 1 to 18 carbon atoms, preferably 8 to 12 carbon atoms. Examples of the salt include alkali metal salts and ammonium salts. The bleaching activators exemplified above may be used alone or in combination of two or more. Among the bleaching activators exemplified above, tetraacetylethylenediamine is preferred from the viewpoint of excellent efficiency in generating an organic peracid.

[0039] In the intra-oral instrument cleanser of the present disclosure, the content of the bleach activator may be appropriately adjusted according to the content of the oxygen bleach, and may be, for example, 0.01 to 5 wt %, preferably 0.1 to 3 wt %, and more preferably 0.5 to 2 wt %.

[0040] (Surfactant) The intra-oral instrument cleanser of the present disclosure may contain a surfactant. The surfactant serves as a component that exerts a chemical cleaning effect, etc.

[0041] The type of surfactant to be incorporated in the intra-oral appliance cleaner of the present disclosure is not particularly limited as long as it is usable as a component of a cleaner, and any of anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants may be used. Among these surfactants, anionic surfactants are preferable.

[0042] Examples of anionic surfactants include α-olefin sulfonate, alkyl sulfate, alkyl benzene sulfonate, alkyl sulfoacetate, and alkane sulfonate. Examples of salt forms of anionic surfactants include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as magnesium and calcium, ammonium salts, amine salts, and acid addition salts such as hydrochloride. Among anionic surfactants, preferred are α-olefin sulfonate and alkyl sulfate, and more preferred are sodium α-olefin sulfonate and sodium lauryl sulfate.

[0043] In the intraoral instrument cleanser of the present disclosure, one type of surfactant may be blended alone, or two or more types of surfactants may be blended in combination.

[0044] In the intra-oral instrument cleanser of the present disclosure, the content of the surfactant is not particularly limited as long as it is capable of exerting a foaming effect when cleaning intra-oral instruments, and may be set appropriately depending on the type of surfactant used, the cleaning power to be provided, etc., and can be, for example, 0.1 to 10 wt %, preferably 0.5 to 7 wt %, and more preferably 1 to 5 wt % in terms of the total amount of surfactant.

[0045] (Sugar alcohol) The oral appliance cleanser of the present disclosure may contain a sugar alcohol. The sugar alcohol is a component that acts as a binder.

[0046] The type of sugar alcohol is not particularly limited, and examples thereof include sorbitol, mannitol, xylitol, erythritol, etc. The sugar alcohols listed above may be used alone or in combination of two or more. Among the sugar alcohols listed above, sorbitol is preferred.

[0047] In the intraoral instrument cleanser of the present disclosure, the sugar alcohol content is, for example, 1 to 30 wt %, preferably 3 to 20 wt %, and more preferably 4 to 15 wt %, in terms of the total amount of sugar alcohol.

[0048] (Polyalkylene glycol) The intraoral instrument cleanser of the present disclosure may contain a polyalkylene glycol. The polyalkylene glycol is a component that functions as a binder.

[0049] Specific examples of the polyalkylene glycol include polyethylene glycol, polypropylene glycol, and polybutylene glycol.

[0050] The polyalkylene glycol may be used alone or in combination of two or more. Among the polyalkylene glycols exemplified above, polyethylene glycol is preferred.

[0051] In the intra-oral instrument cleanser of the present disclosure, the content of polyalkylene glycol is, for example, 0.1 to 5 wt %, preferably 0.5 to 2 wt %, and more preferably 0.5 to 1.5 wt %.

[0052] (lubricant) The oral appliance cleanser of the present disclosure may contain a lubricant to facilitate the molding process into tablets.

[0053] The type of lubricant is not particularly limited, but examples thereof include magnesium stearate, calcium stearate, sodium stearyl fumarate, sucrose fatty acid esters, sodium lauryl sulfate, talc, light anhydrous silicic acid, and hydrated silicon dioxide.

[0054] The lubricant may be used alone or in combination of two or more. Among the lubricants exemplified above, magnesium stearate is preferred.

[0055] In the intraoral instrument cleanser of the present disclosure, the content of the lubricant is, for example, 0.01 to 1 wt %, preferably 0.015 to 0.5 wt %, and more preferably 0.02 to 0.3 wt %.

[0056] Other additives that can be incorporated into the intraoral instrument cleaner of the present disclosure include, for example, base materials (sodium sulfate, etc.), flavors (other than menthol), flavor impregnating agents, enzymes (proteases, etc.), colorants, magnesium oxide, deodorants, tartar inhibitors, rust inhibitors, chelating agents, pH adjusters, sweeteners, cooling agents (other than menthol), foam stabilizers, preservatives, antibacterial agents (other than isopropylmethylphenol and its structural isomers), bactericides (other than isopropylmethylphenol and its structural isomers), preservatives, bulking agents, excipients, disintegrants, and fluidizing agents. The other components exemplified above may be incorporated alone or in any combination of two or more.

[0057] 2. Formulation and manufacturing method of oral instrument cleaner The tablet-shaped intraoral instrument cleaner of the present disclosure is obtained by tableting using the intraoral instrument cleaner for tablets of the present disclosure. Formulation into tablets can be performed by a commonly used tableting method. For example, a raw material mixture obtained by mixing the (A) or (B) component with the (C) component and other additives that are blended as necessary may be subjected to a tableting process. The intraoral instrument cleaner for tablets of the present disclosure contains the (C) component together with the (A) or (B) component, so that sticking can be suppressed during tableting and production losses in the tableting process can be suppressed, thereby achieving high production efficiency in industrial production. In addition, the mixture may be granulated into granules as necessary prior to the tableting process.

[0058] In addition, in the tablet-shaped intraoral instrument cleanser of the present disclosure, the weight per tablet is not particularly limited and may be appropriately set based on ease of use, but it is desirable to set the weight per tablet to the amount required for one intraoral instrument cleansing. Specifically, the weight per tablet of the tablet-shaped intraoral instrument cleanser of the present disclosure is 1 to 4 g, preferably 2 to 3 g.

[0059] 3. Uses of oral instrument cleaners The tablet-form intra-oral instrument cleanser of the present disclosure is used as a cleaner for various intra-oral instruments, but is particularly suitable for use as a denture cleanser.

[0060] 4. How to use the oral instrument cleaner When the tablet-form intraoral instrument cleanser of the present disclosure is added to water, heated if necessary, and the intraoral instrument (preferably a denture) to be cleaned is placed in the water, the tablet-form intraoral instrument cleanser of the present disclosure dissolves and the intraoral instrument is cleaned.

[0061] The water used when cleaning intraoral instruments using the tablet-form intraoral instrument cleanser of the present disclosure is not particularly limited, but examples thereof include tap water, purified water, distilled water, and physiological saline.

[0062] When cleaning an intra-oral instrument using the tablet-form intra-oral instrument cleanser of the present disclosure, the intra-oral instrument may be immersed in water and then the tablet-form intra-oral instrument cleanser of the present disclosure may be added, or the intra-oral instrument may be immersed in water after the tablet-form intra-oral instrument cleanser of the present disclosure has been added.

[0063] In addition, in cleaning intraoral instruments, the ratio of the tablet-type intraoral instrument cleaner of the present disclosure to water is appropriately set according to the composition of the tablet-type intraoral instrument cleaner of the present disclosure, and for example, the tablet-type intraoral instrument cleaner may be usually about 1 to 10 parts by weight, preferably about 1 to 5 parts by weight, per 100 parts by weight of water. More specifically, in one cleaning of intraoral instruments, 100 to 200 mL of water is prepared, and 1 to 20 g, preferably 1 to 10 g, more preferably 1 to 5 g of the tablet-type intraoral instrument cleaner of the present disclosure is added thereto.

[0064] The temperature during cleaning of intraoral instruments may be about room temperature. The time for immersing intraoral instruments in the cleaning solution is usually 5 minutes to 24 hours, preferably 10 minutes to 12 hours, and more preferably 30 minutes to 8 hours.

[0065] In addition, while cleaning the intra-oral appliances, it is not necessary to stir the water to which the intra-oral appliance cleanser has been added. However, in order to more effectively remove dirt and the like from the intra-oral appliances, the water may be stirred as necessary, and the intra-oral appliances may be scrubbed with a cleaning tool such as a brush. EXAMPLES

[0066] The present invention will be described in more detail below with reference to examples, but the present disclosure is not limited to these examples.

[0067] Test example (evaluation of sticking) The components shown in Tables 1 and 2 were mixed using a Lödige mixer (Matsubo Co., Ltd., model number: M20) to form a composition, which was then compressed into tablets at a pressure of 5t using a 20φ die and a tableting machine (Kikusui Seisakusho Co., Ltd., rotary powder molding machine, model number: CLEC1518SS7JZ). The oral cavity instrument cleaner was prepared in tablet form, each tablet being 2 g. Three sets of mortars and punches were evenly placed on the rotating plate of the tablet press. After continuously pressing 100 tablets of the oral cavity instrument cleaner, the mortars and punches were observed, and the number of sets of mortars and punches in which sticking occurred in either the mortar or the punches was counted. The results are shown in Tables 1 and 2.

[0068] [Table 1]

[0069] [Table 2]

[0070] As shown in Tables 1 and 2, when malic acid was added to an intraoral instrument cleaner containing isopropylmethylphenol, thymol, or l-menthol, the occurrence of sticking could be effectively suppressed (Examples 1 to 6). On the other hand, when malic acid was not added to an intraoral instrument cleaner containing isopropylmethylphenol, thymol, or l-menthol, the occurrence of sticking was observed (Comparative Examples 1 to 15). Furthermore, no sticking occurred with an intraoral instrument cleaner that did not contain any of isopropylmethylphenol, thymol, or l-menthol (Reference Example 1).

[0071] Prescription Examples Tablet-shaped intraoral instrument cleaners having the compositions shown in Tables 3 and 4 were prepared in the same manner as in the above test examples, and the sticking was evaluated. The results are shown in Tables 3 and 4. From the results in Tables 3 and 4, it was confirmed that the occurrence of sticking can be effectively suppressed when malic acid is added to intraoral instrument cleaners containing isopropylmethylphenol, thymol, or l-menthol.

[0072] [Table 3]

[0073] [Table 4]

Claims

1. A tablet-type oral device cleaner comprising (A) at least one selected from the group consisting of isopropylmethylphenol and thymol, and (C) at least one selected from the group consisting of malic acid and its salts, wherein the content of component (C) is 0.01 to 10% by weight, and which is used by dissolving it in water.

2. The oral device cleaner for tablets according to claim 1, wherein the oral device cleaner is a denture cleaner.

3. A method for producing a tablet-shaped oral device cleaning agent that is used by dissolving it in water, comprising: (A) at least one selected from the group consisting of isopropylmethylphenol and thymol; and (C) at least one selected from the group consisting of malic acid and salts thereof, wherein the content of component (C) is 0.01 to 10% by weight, and subjecting the raw material mixture to a tableting step.