Aerosol pirfenidone and pyridone analog compounds and uses thereof
By developing inhaled preparations of Pirfintian or similar compounds, the problems of low efficacy and many adverse reactions after oral administration of drugs in the prior art have been solved, and efficient treatment of fibrosis and inflammation have been achieved, and the risk of systemic exposure of drugs has been reduced.
JP2025060674AInactive Publication Date: 2025-04-10AVALYN PHARMA INC
Patent Information
- Application Number
- JP2024216979
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2012-01-06
- Filing Date
- 2024-12-11
- Publication Date
- 2025-04-10
- Estimated Expiration
- Not applicable · inactive patent
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Figure 2025060674000001_ABST
Abstract
To provide formulations for the prevention or treatment of various fibrotic and inflammatory diseases, including diseases associated with the lungs, heart, kidneys, liver, eyes and central nervous system.SOLUTION: Provided is an aqueous solution for nebulized inhalation administration comprising: water; pirfenidone, or a pyridone analog compound, at a concentration from about 0.1 mg / mL to about 60 mg / mL; and one or more co-solvents, the osmolality of the aqueous solution being from about 50 mOsmol / kg to about 6000 mOsmol / kg.SELECTED DRAWING: Figure 1
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Citation Information
Patent Citations
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