Biphenyl sulfonamide compounds for treatment of kidney diseases or disorders
By using a combination of drugs containing structure (I), the problem of reducing proteinuria in the prior art when treating renal diseases or disorders such as FSGS, IgA nephropathy and IMN is solved, and the effect of effectively reducing the urine protein to creatinine ratio is achieved.
JP2025060754APending Publication Date: 2025-04-10TRAVERE THERAPEUTICS INC
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Patent Information
- Application Number
- JP2024225044
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2016-11-16
- Filing Date
- 2024-12-20
- Publication Date
- 2025-04-10
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Figure 2025060754000001_ABST
Abstract
To provide compositions and methods for treating various kidney diseases or disorders (e.g., FSGS, IgA nephropathy, and IMN).SOLUTION: The present invention relates to a pharmaceutical composition comprising a compound having structure (I), or a pharmaceutically acceptable salt thereof, for use in a method of treating a kidney disease or disorder in a subject in need thereof, the method comprising administering to the subject the pharmaceutical composition (i) in an amount sufficient to achieve a urine protein to creatinine (UP / C) ratio of less than or equal to 1.5 g / g; (ii) in an amount sufficient to achieve or maintain a UP / C ratio of less than or equal to 1.5 g / g.SELECTED DRAWING: Figure 1A
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