Improved thiopurine formulations and methods of treatment
JP2025510301APending Publication Date: 2025-04-14DOUGLAS PHARMA
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Patent Information
- Application Number
- JP2024557241
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2022-03-25
- Filing Date
- 2023-03-24
- Publication Date
- 2025-04-14
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Figure 2025510301000020 
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Abstract
The present invention relates generally to improved formulations of 6-thioguanine (6-TG), their methods of preparation, and their use in methods of treatment. The present invention provides pharmaceutical compositions comprising 6-TG and a polyethylene oxide polymer having a molecular weight of about 900,000 g / mol to about 9,000,000 g / mol, their methods of preparation, and their use in methods for treating distal intestinal diseases or conditions responsive to 6-TG, wherein 6-TG is released in the distal intestine.
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