Engineered fibroblast growth factor variants

JP2025510400APending Publication Date: 2025-04-14マルタス·バイオテクノロジー·リミテッド
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Patent Information

Application Number
JP2024575654
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-03-11
Filing Date
2023-03-10
Publication Date
2025-04-14

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Abstract

The present invention relates to improved growth factor polypeptide variants, in particular polypeptides comprising any one of SEQ ID NOs: 2-7 or a sequence having at least 80% similarity thereto, wherein the FGF polypeptide exhibits increased biological activity, solubility and / or stability compared to the wild-type FGF2 polypeptide of SEQ ID NO: 1. The present invention further provides nucleic acid sequences encoding the FGF polypeptides of the invention, as well as a method for growing animal cells comprising culturing the animal cells in a culture medium comprising the FGF polypeptide of the invention.
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