Cell therapy

JP2025510686APending Publication Date: 2025-04-15UNIVERSITY OF BASEL
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Patent Information

Application Number
JP2024555939
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-03-22
Filing Date
2023-03-22
Publication Date
2025-04-15

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Abstract

The present invention is in the field of regenerative medicine and provides compositions and methods for treating cancer and / or infectious diseases in patients.The present invention provides cells, preferably immune cells, genetically engineered to force the expression of phosphoglycerate dehydrogenase (PHGDH), as well as expression constructs, vectors, and methods for their preparation and use.The present invention provides an expression cassette comprising a polynucleotide sequence encoding phosphoglycerate dehydrogenase (PHGDH).
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