Transdermal delivery device and method of use for peptide delivery
JP2025519589A5Pending Publication Date: 2026-06-15PASSPORT TECHNOLOGIES INC +2
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- PASSPORT TECHNOLOGIES INC
- Filing Date
- 2023-06-08
- Publication Date
- 2026-06-15
AI Technical Summary
⚠Technical Problem
Current peptide drugs for Alzheimer's disease are unstable in vivo and face challenges in delivering peptides across the blood-brain barrier effectively.
⚗Method used
A transdermal delivery system comprising a patch with a non-aggregated peptide, such as p3-Alcβ9-19, embedded in a matrix that includes sugars and organic acids, applied using a transdermal microporation device to create microchannels in the skin, facilitating the absorption of the peptide.
🎯Benefits of technology
The system achieves enhanced bioavailability and sustained delivery of the peptide to the brain, maintaining therapeutic levels for an extended period and improving mitochondrial activity and neuron survival.
✦ Generated by Eureka AI based on patent content.
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Abstract
Patches, methods, devices, and systems for delivering non-aggregating peptides such as arcadien and fragments thereof are disclosed herein. In some embodiments, the patch includes a backing, a matrix containing a non-aggregating peptide disposed within the matrix, and a release liner. In other embodiments, the method includes opening at least one channel in the skin of a subject and applying a patch as described herein, thereby treating a brain-related disease or disorder such as Alzheimer's disease.
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