HSD17B13 inhibitor

JP2025523357A5Pending Publication Date: 2026-06-15BOEHRINGER INGELHEIM INT GMBH
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
BOEHRINGER INGELHEIM INT GMBH
Filing Date
2023-06-06
Publication Date
2026-06-15

AI Technical Summary

⚠Technical Problem

Current treatments for non-alcoholic steatohepatitis (NASH) and related liver diseases lack effective inhibitors targeting HSD17B13, a key enzyme implicated in these conditions, necessitating the development of potent and selective HSD17B13 inhibitors to manage lipid biosynthesis and disease progression.

⚗Method used

Development of heteroaryl-substituted 2,6-difluorophenol compounds that act as selective HSD17B13 inhibitors, capable of modulating lipid biosynthesis and potentially treating conditions like NASH and metabolic disorders, with the compounds existing in various tautomeric forms and being administered in combination with additional therapeutic agents.

🎯Benefits of technology

The compounds effectively inhibit HSD17B13, offering therapeutic benefits in treating non-alcoholic steatohepatitis and metabolic disorders, with flexible dosing regimens and formulations for optimal patient outcomes.

✦ Generated by Eureka AI based on patent content.

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Abstract

The present invention encompasses a heteroaryl-substituted 2,6-difluorophenol compound of formula (I) (wherein the groups A1 to A3 and Z have the meanings given in the claims and the specification), their use in pharmaceutical compositions containing these compounds, and, in particular, their use as medicaments for preventing the progression of liver diseases to non-alcoholic steatohepatitis, fibrosis and cirrhosis, which are later stages from steatosis. TIFF2025523357000115.tif61124
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