Precision filtration container

Abstract

The present invention relates to a precision filtration container (2) having a base (1) for a precision filtration container (2), wherein the container includes at least one microfilter (3) and is configured to create a fluid passage for fluid passing from a fluid inlet (4) to a fluid outlet (5) through the microfilter (3). In the precision filtration container (2), the base (1) is a one-piece body, i.e., made of a single piece. A microfilter sheet (6) for accommodating and fixing the at least one microfilter (3) is provided on the base (1). At least one first valve half-chamber (7) configured to accommodate a first movable valve element (8) configured to move from a valve-open position to a valve-closed position is provided on the base (1). The at least one first valve half-chamber (7) has at least one first contact surface (9) for sealing the movable valve element (8). The precision filtration container (2) has a container bell (28), and the container bell (28) has a cylindrical bell body (42) whose first lower end can be sealed and connected to the base (1) and whose opposite upper end is closed by a bell cap (43).

Description

Technical Field

[0001] The present invention generally belongs to the field of bases for precision filtration containers and relates to a precision filtration container having said base.

[0002] In particular, the present invention relates to a precision filtration container in the field of applications that mainly require pharmaceutical applications, biotechnology, microelectronics, and effective filtration and purification techniques suitable for obtaining high-purity and sterile non-pyrogenic fluids.

Background Art

[0003] Similar to many other production fields, in pharmaceutical applications, filtration for both sterilization and ultra-clean fluid production is currently widely practiced.

[0004] The first applications date back to the end of the First World War with the introduction of microporous membrane filters that are available at different retention levels. Said membrane filters (hereinafter also simply referred to as "filters") appear in sheet form and are sold in the form of discs or cartridges that can cover applications requiring anything from just a few cm2 (in the form of a disc) to several m2 (for example in the case of a cartridge having a pleated membrane).

[0005] For use, the filter needs to be installed in a filter holder (hereinafter referred to as a "container"). Containers suitable for both sheet filters and filtration cartridges can be utilized.

[0006] Prior art containers for cartridges (see Figure 1) consist of a cartridge holder "base" and a closing "bell" configured to house a precision filtration cartridge. An attachment for connecting the precision filtration cartridge and two pipes with bends, one bend for introducing the solution to be filtered and the other bend connected to the center of the filter holder attachment, is present in the base and can take in the fluid emerging from the inner central part of the filter.

[0007] This type of solution is described, for example, in GB2202164A and EP0051373.

[0008] In order to use these known microfiltration vessels, the vessels need to be equipped with a series of accessories and instruments so that they can create a filtration barrier and control and enable microfiltration to achieve the purpose set by the process.

[0009] Its use is related to both the filtration of liquid solutions (using hydrophilic filters) and the filtration of gases (using hydrophobic filters). There are a variety of vessels and filters, which can cover the most diverse applications.

[0010] The vessels equipped with accessories and instruments are the subject of the project, and its success depends on the attitude of the designer and ultimately on the installer. In particular, the selection of accessories and assembly modes is an important aspect in the success of the project.

[0011] In particular, in order to perform the functions required by the process, the vessels equipped with filtration cartridges must be equipped with a series of accessories selected at the design stage to enable their correct use.

[0012] For example, at the inlet of the vessel, - a shut-off valve for the inlet bend, - a temperature sensor reaching inside the filter, - an upstream or inlet side drain valve that enables emptying, discharging steam during sterilization, and introducing water to check the integrity of the hydrophobic filter, may need to be connected.

[0013] For example, in the vessel closure bell, - a pressure sensor, - an instrument configured to check the integrity of the hydrophobic filter, - a valve for discharging air carried in the liquid, -Shut-off valve on the connection going to the condensate recovery in case steam needs to come out of the top of the bell during sterilization, It may be necessary to connect

[0014] For example, at the outlet of the container, -Shut-off valve at the outlet bend, - Temperature sensor that reaches inside the filter, - option for sterile sampling of the filtrate immediately at the outlet of the filter before the shut-off valve, It may be necessary to connect

[0015] All of these accessories are found on the market, but often connect components that are unsuitable for the aseptic processing applications required in pharmaceutical processes or high purity process microelectronics.

[0016] These accessories are included in the process. -Unused part, - asymptotic closures that are difficult to clean using automated "Cleaning in Place" cleaning techniques, - a valve actuator in direct contact with the fluid to be purified; - the space requirements around the container which increase the dead volume of the container, which often holds very expensive products; - undesired contamination due to the introduction of measuring probes, - contamination due to sample collection, may be brought in.

[0017] Therefore, in the fields of pharmaceutical applications, biotechnology and applications requiring effective filtration and purification techniques suitable for obtaining highly pure, sterile and non-pyrogenic fluids, the need to completely empty the filtration vessel at the end of the process is strongly felt, especially when high cost products are present.

[0018] In industries with high technological content, a filtration container equipped with features configured to be used for such applications and with specially researched and manufactured components enabling its process control cannot be utilized.

[0019] Generally, known containers are designed and manufactured for other applications and are equipped with reworked components such as specific connections, seals, electropolishing, controlled and certified roughness, etc., and comply with US medical and pharmaceutical standards such as FDA, USP, 3A, BPE2000, etc., as well as standards in the EU, Japan, and Russia.

[0020] In industries serving the above fields, maintaining the same effluent liquid quality achieved by filtration until the point of use downstream of the filter is an important privilege, which is generally represented by the containers recovered for market release.

[0021] Therefore, there is a strong need to propose a filter holder container, particularly a base for this container, which - is compact, - can be completely emptied when necessary without having a residue stagnation zone, - is easy to produce, - enables aseptic processing in the pharmaceutical field or high-purity processes.

Summary of the Invention

Problems to be Solved by the Invention

[0022] Therefore, the object of the present invention is to overcome the drawbacks of the prior art and to be able to meet the above-mentioned needs by proposing a microfilter holder container base that can reliably fulfill the above-mentioned needs.

Means for Solving the Problems

[0023] These and other objects are achieved by the precision filtration container according to claim 1.

[0024] Some advantageous embodiments are the subject of the dependent claims.

[0025] By the general embodiments and variants described above and further below, the following advantages can be obtained.

[0026] The proposed base and the proposed fine filtration container make it possible to use a process control device integrated with the base and the container, form a compact and aseptic assembly, and the geometric shape for making it aseptic is mostly made of the base and a part, that is, a single piece.

[0027] The proposed solution makes it possible to have a container for the filter, and its structure (mainly the filter holder base and the dependently closed bell) is designed to fulfill the intended use, and all available accessories useful for making the system functional are integrated into its body.

[0028] In the proposed solution, the user can find an available filtration system with accessories.

[0029] This solution has several advantages, namely, - less space than the solutions known to date, - performance quality without stagnation points, - use of specific parts without unused parts and asymptotic blockages, - dedicated access ports for pressure and temperature probes, - specific access ports for sample collection probes, - all control valves integrated into the base body, - all drain and ventilation valves and connecting fixtures dependently in the bell, - being able to wash and decontaminate together with the container and the filter, - being able to sterilize together with the container and the filter equipped with on-site sensors, are provided.

[0030] In particular, the base of the container is shaped to accommodate all commercially available types of cartridges and to avoid product residue upstream of the cartridge at the end of filtration.

Brief Description of the Drawings

[0031] Further features and advantages of the present invention will become apparent from the following description of its preferred embodiments, presented by way of non-limiting example with reference to the accompanying drawings.

[0032]

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Best Mode for Carrying Out the Invention

[0033] Next, the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art can manufacture and use the present invention. Various changes to the described embodiments will be readily apparent to those skilled in the art, and the described general principles can be applied to other embodiments and applications without departing from the scope of protection of the present invention defined in the appended claims. Therefore, the present invention should not be considered limited to the described and illustrated embodiments, but the broadest scope of protection consistent with the described and claimed features should be recognized.

[0034] Unless otherwise defined, all technical and scientific terms used in this specification have the same meaning as commonly used by those skilled in the art to which this invention belongs. In case of conflict, this description, including the provided definitions, will control. Further, the examples are provided for illustrative purposes only and should not be considered limiting as such.

[0035] To facilitate the understanding of the embodiments described in this specification, some specific embodiments are referred to and specific terms are used to describe them. The terms used in this specification are for the purpose of describing only specific embodiments and are not intended to limit the scope of the present invention.

[0036] According to a general embodiment, the base for the precision filtration vessel 2 is denoted by reference numeral 1 in the drawings.

[0037] The precision filtration vessel 2 or the vessel includes at least one microfilter 3, for example, a cylindrical cartridge having an outer peripheral inlet and a central outlet, and is configured to create a fluid passage for fluid passing from a fluid inlet 4 to a fluid outlet 5 through the microfilter 3.

[0038] The base 1 is a one-piece body, i.e., a body made of a single piece. For example, a metal monobloc machined by chip removal.

[0039] A microfilter sheet 6 is provided on the base 1 for accommodating and fixing the at least one microfilter 3. At least a first valve half-chamber 78 is provided on the base 1 and configured to accommodate a first movable valve element configured to move from a valve open position to a valve closed position.

[0040] The at least one first valve half-chamber 7 has at least one first abutment surface 9 for sealing the movable valve element 8.

[0041] According to one embodiment, the first valve half-chamber 7 is a fluid inlet valve half-chamber.

[0042] According to another embodiment, the first valve half-chamber is a fluid outlet valve half-chamber.

[0043] According to one embodiment, at least one second valve half-chamber 10 configured to accommodate a second movable valve element 11 configured to move from a valve open position to a valve closed position is provided on the base 1.

[0044] According to one embodiment, the at least one second valve half-chamber 10 has at least one second abutment surface 12 for sealing the second movable valve element 11.

[0045] According to one embodiment, the second valve half-chamber 10 is a fluid outlet valve half-chamber.

[0046] According to another embodiment, the second valve half-chamber is a fluid inlet valve half-chamber.

[0047] According to one embodiment, the first or second valve half-chamber 7 or 10 is configured to be connected and sealed to a first or second valve counter-half-chamber 13 or 14 so as to form a first or second chamber 15 or 16 of the first or second valve that houses the first or second movable valve element 8 or 11.

[0048] According to one embodiment, at least one fluid inlet or outlet pipe section 17 or 18 is provided on the base 1.

[0049] According to one embodiment, the at least one fluid inlet or outlet pipe section 17 or 18 opens into the first valve half-chamber 7.

[0050] According to one embodiment, at least one fluid inlet or outlet pipe section 18 or 17 is provided on the base 1.

[0051] According to one embodiment, the at least one fluid inlet or outlet pipe section 18 or 17 opens into the second valve half-chamber 10.

[0052] According to one embodiment, at least one third valve half-chamber 19 is provided on the base 1 and is configured to house a third movable valve element 20 configured to move from a valve open position to a valve closed position.

[0053] According to one embodiment, the at least one third valve half chamber 19 has at least one third contact surface 21 for sealing the third movable valve element 20.

[0054] According to one embodiment, at least one third upstream drain valve half chamber 19 is provided in the base 1 and configured to accommodate a third movable valve element 20 configured to move from an open valve position to a closed valve position.

[0055] According to one embodiment, the at least one third upstream valve half chamber 19 has at least one third contact surface 21 for sealing the third movable valve element 20.

[0056] According to one embodiment, at least one fourth valve half chamber 22 is provided in the base 1 and configured to accommodate a fourth movable valve element 23 configured to move from an open valve position to a closed valve position.

[0057] According to one embodiment, the at least one fourth valve half chamber 22 has at least one fourth contact surface 24 for sealing the fourth movable valve element 20.

[0058] According to one embodiment, at least one fourth downstream valve half chamber 22 is provided in the base 1 and configured to accommodate a fourth movable valve element 23 configured to move from an open valve position to a closed valve position.

[0059] According to one embodiment, the at least one fourth downstream valve half chamber 22 has at least one fourth contact surface 24 for sealing the fourth movable valve element 20.

[0060] According to one embodiment, at least one upstream or downstream drain pipe section 25 or 26 is provided in the base 1.

[0061] According to one embodiment, the at least one upstream or downstream drain pipe section 25 or 26 opens into the third valve half chamber (19).

[0062] According to one embodiment, at least one upstream or downstream drain pipe section 26 or 25 is provided on the base 1.

[0063] According to one embodiment, the at least one upstream or downstream drain pipe section 26 or 25 opens into the fourth valve half chamber 22.

[0064] According to one embodiment, the base 1 has a base connection flange 27 for connection with the container bell 28 to form the body of the fine filtration container 2.

[0065] According to one embodiment, the container bell 28 has a movable connection counter flange 29 configured to face the base connection flange 27.

[0066] According to one embodiment, the flanges and counter flanges 27, 29 are surrounded in a circular shape by at least one screw clamp 30, and the screw clamp 30 accommodates the flanges and counter flanges 27, 29 in an inverted "V" - shaped groove 31 and is, for example, a V - band adjustable clamp of the I - bolt scaffold clamp / swivel coupler type.

[0067] According to one embodiment, the base 1 has a peripheral sleeve 32, an upper container bottom surface 33, and an outer lower surface 34.

[0068] According to one embodiment, the peripheral sleeve 32 has four leveling elements 35, 36, 37, 38 in two pairs facing each other.

[0069] According to one embodiment, the fluid inlet pipe section 17 and the fluid outlet pipe section 18 are provided at two opposing levelings 35, 37.

[0070] According to one embodiment, the third valve half chamber 19 and the fourth valve half chamber 22 open into two opposing levelings 36, 38.

[0071] According to one embodiment, the first valve half chamber 7 and the second valve half chamber 10 open into the upper container bottom surface 33.

[0072] According to one embodiment, the microfilter sheet 6 opens into the upper container bottom surface 33 and is fluidly connected to the second valve half chamber 10.

[0073] According to one embodiment, the upstream drain pipe section 25 and the downstream drain pipe section 26 open into the outer lower surface 34.

[0074] According to one embodiment, the upstream drain pipe section 25 is fluidly connected to the third valve half chamber 19.

[0075] According to one embodiment, the downstream drain pipe section 26 is fluidly connected to the fourth valve half chamber 22.

[0076] According to one embodiment, the base 1 has a peripheral channel 39, and the peripheral channel fluidly connects the third valve half chamber 19 and the first valve half chamber 7.

[0077] According to one embodiment, each valve half chamber 7, 10, 19, 22 is sealed by valve counter half chambers 13, 14, 40, 41 connected by threaded flanges.

[0078] According to one embodiment, when the base 1 is in the use position, each valve half chamber 7, 10, 19, 22 and / or each valve counter half chamber 13, 14, 40, 41 has aseptic geometries, that is, it can discharge any minimum amount of fluid, in other words, there is no fluid stagnation zone.

[0079] According to one embodiment, when the base 1 is in the use position, each pipe section 17, 18, 25, 26 has aseptic geometries, that is, it can discharge any minimum amount of fluid, in other words, there is no fluid stagnation zone.

[0080] The present invention also relates to a precision filtration container 2 having a base 1 according to any one of the above-described embodiments.

[0081] According to one embodiment, the precision filtration container 2 has a container bell 28.

[0082] According to one embodiment, the container bell 28 has a cylindrical bell body 42 whose first lower end can be sealed and connected to the base 1, and the opposite upper end is closed by a bell cap 43.

[0083] According to one embodiment, the cylindrical bell body 42 and the bell cap 43 are firmly connected to form a single piece.

[0084] According to one embodiment, the bell cap 43 is an integral body, that is, it is made of a single piece.

[0085] According to one embodiment, at least one fifth valve half chamber 44 is provided in the bell cap 43 and is configured to accommodate a fifth movable valve element 45 configured to move from a valve open position to a valve closed position.

[0086] According to one embodiment, the at least one fifth valve half chamber 43 has at least one fifth contact surface 46 for sealing the fifth movable valve element 45.

[0087] According to one embodiment, at least one sixth valve half chamber 47 is provided in the bell cap 43 and configured to accommodate a sixth movable valve element 48 configured to move from a valve open position to a valve closed position.

[0088] According to one embodiment, the at least one sixth valve half chamber 47 has at least one sixth abutment surface 49 for sealing the sixth movable valve element 48.

[0089] According to one embodiment, at least one level sensor chamber 50 is provided in the bell cap 43 and has a level sensor connection flange 51 for connection with a clamp connection adapter unit 52, i.e., a zero dead leg (ZDL) connection flange, i.e., a ZDL connection, and is configured to connect a level sensor 53.

[0090] According to one embodiment, at least one manometer connection pipe 54 is provided in the bell cap 43 for connection of a manometer 55.

[0091] According to one embodiment, at least one integrity test pipe section 56 is provided in the bell cap 43.

[0092] According to one embodiment, the at least one integrity test pipe section 56 is fluidly connected to the sixth valve half chamber 47.

[0093] According to one embodiment, when the base 1 is connected to the container bell 28, it defines an inner microfilter chamber 57 that houses at least one microfilter 3 that separates the fluid inlet pipe section 17 from the fluid outlet pipe section 18.

[0094] According to one embodiment, the base 1 has at least one blind seat 58 for the connection of the container support leg 59.

[0095] To meet specific conditional needs, those skilled in the art can make several changes and adaptations to the foregoing embodiments and can also make substitutions with other functionally equivalent elements, without departing from the scope of the following claims.

[0096] According to one embodiment, when the base is not attached, the microfilter sheet 6 is provided on the base 1 that faces outward from the opposite side with respect to the way the first contact surface 9 faces outward.

[0097] According to one embodiment, when the base is not attached, the microfilter sheet 6 is provided on the base 1 that faces outward in a different direction with respect to the way the first contact surface 9 faces outward.

[0098] According to one embodiment, the first movable valve element 8 is received in the first valve half chamber 7 so as to move along the first movable valve element movement path to contact the first contact surface 9.

[0099] According to one embodiment, the microfilter sheet 6 is different from the first contact surface 9.

Explanation of Reference Numerals

[0100] 1 Base 2 Precision filtration container 3 Microfilter 4 Fluid inlet 5 Fluid outlet 6 Microfilter sheet, such as a cord sheet 7 - Bayonet coupling 7 First inlet or valve half chamber 8 First movable valve element 9 First contact surface 10 Second outlet or valve half chamber 11 Second movable valve element 12 Second abutting surface 13 First valve counter half chamber 14 Second valve counter half chamber 15 First chamber of the first valve 16 Second chamber of the second valve 17 Liquid inlet pipe section 18 Fluid outlet pipe section 19 Third upstream drain or valve half chamber 20 Third movable valve element 21 Third abutting surface 22 Fourth downstream drain or valve half chamber 23 Fourth movable valve element 24 Fourth abutting surface 25 Upstream drain pipe section 26 Downstream drain pipe section 27 Base connection flange 28 Container bell 29 Movable bell connection counter flange 30 Screw clamp 31 Inverted V-shaped groove 32 Peripheral sleeve 33 Upper container bottom surface 34 Outer lower surface 35 Sleeve leveling 36 Sleeve leveling 37 Sleeve leveling 38 Sleeve leveling 39 Peripheral channel 40 Third valve counter half chamber 41 Fourth valve counter half chamber 42 Cylindrical bell body 43 Bell cap 44 Fifth ventilation or valve half chamber 45 Fifth movable valve element 46 Fifth abutting surface 47 Sixth integrity test or valve half chamber 48 Sixth movable valve element 49 Sixth abutting surface 50 Level Sensor Chamber 51 Level Sensor Connection Flange 52 Clamp Connection Adapter Unit 53 Level Sensor 54 Manometer Connection Pipe 55 Manometer 56 Integrity Test Pipe Section 57 Inner Microfilter Chamber 58 Blind Sheet 59 Container Support Leg 60 Inlet Valve 61 Outlet Valve 62 Upstream Drain Valve 63 Downstream Drain Valve 64 Vent Valve 65 Integrity Test Valve 66 Inlet Connection 67 Outlet Connection 68 Upstream Drain Connection 69 Downstream Drain Connection 70 Integrity Test Pipe Connection 71 Vent Pipe Section

Claims

1. A microfiltration container having a base for a microfiltration container, The container includes at least one microfilter and is configured to create a fluid passage through which a fluid passing from a fluid inlet to a fluid outlet passes through the microfilter, in a precision filtration container, The aforementioned base is a single body, that is, made from a single piece. A microfilter sheet for housing and fixing the at least one microfilter is provided on the base. The base is provided with at least one first valve half-chamber configured to house a first movable valve element configured to move from a valve open position to a valve closed position. The at least one first valve half chamber has at least one first contact surface for sealing the movable valve element, The aforementioned precision filtration container has a container bell, The container bell has a cylindrical bell body in which the first lower end can be sealed and connected to the base, and the opposite upper end is closed by a bell cap. Precision filtration container.

2. The first valve half-chamber is a fluid inlet valve half-chamber, or The first valve half-chamber is a fluid outlet valve half-chamber. A precision filtration container according to claim 1.

3. The base is provided with at least one second valve half-chamber configured to house a second movable valve element configured to move from a valve open position to a valve closed position. The at least one second valve half chamber has at least one second contact surface for sealing the second movable valve element. A precision filtration container according to claim 1.

4. The second valve half-chamber is a fluid outlet valve half-chamber, or The aforementioned second valve half-chamber is a fluid inlet valve half-chamber. A precision filtration container according to claim 1.

5. The first or second valve half chamber is configured to be coupled to and sealed with the first or second valve counter half chamber so as to form the first or second chamber of the first or second valve that houses the first or second movable valve element. A precision filtration container according to claim 3.

6. The base is provided with at least one fluid inlet or outlet pipe section. The at least one fluid inlet or outlet pipe section opens into the first valve half chamber, or The base is provided with at least one fluid outlet or inlet pipe section. The at least one fluid outlet or inlet pipe section opens into the second valve half chamber. A precision filtration container according to claim 3.

7. The base is provided with at least one third valve half-chamber configured to house a third movable valve element configured to move from a valve open position to a valve closed position. The at least one third valve half chamber has at least one third contact surface for sealing the third movable valve element, or The base is provided with at least one third upstream drain valve half-chamber configured to house a third movable valve element configured to move from a valve open position to a valve closed position. The at least one third upstream valve half chamber has at least one third contact surface for sealing the third movable valve element, A precision filtration container according to claim 1.

8. The base is provided with at least one fourth valve half-chamber configured to house a fourth movable valve element configured to move from a valve open position to a valve closed position. The at least one fourth valve half-chamber has at least one fourth contact surface for sealing the fourth movable valve element, or The base is provided with at least one fourth downstream valve half-chamber configured to house a fourth movable valve element configured to move from a valve open position to a valve closed position. The at least one fourth downstream valve half-chamber has at least one fourth contact surface for sealing the fourth movable valve element. A precision filtration container according to claim 1.

9. The base is provided with at least one upstream or downstream drain pipe section. The at least one upstream or downstream drain pipe section opens into the third valve half chamber, or The base is provided with at least one downstream or upstream drain pipe section. The at least one downstream or upstream drain pipe section opens into the fourth valve half chamber. The precision filtration container according to claim 7.

10. The base has a base connecting flange for connecting to the container bell to form the body of the microfiltration container. The container bell has a movable connecting counter flange configured to face the base connecting flange, The flange and the counter flange are enclosed in a circle by at least one screw clamp, the screw clamp housing the flange and the counter flange in an inverted "V" shaped groove, and is, for example, an I-bolt scaffolding clamp / swivel coupler type V-band adjustable clamp. A precision filtration container according to claim 1.

11. The base has a peripheral sleeve, an upper container bottom surface, and an outer lower surface. The aforementioned peripheral sleeve has four leveling elements, two of which face each other. The fluid inlet pipe section and the fluid outlet pipe section are provided on two opposing levelings. The third valve half-chamber and the fourth valve half-chamber open to two opposing levelings, The first valve half-chamber and the second valve half-chamber open to the bottom surface of the upper container, The microfilter sheet has an opening in the bottom surface of the upper container and is fluidly connected to the second valve half chamber. A precision filtration container according to claim 1.

12. The upstream drain pipe section and the downstream drain pipe section open to the outer lower surface, The upstream drain pipe section is fluidly connected to the third valve half chamber. The downstream drain pipe section is fluidly connected to the fourth valve half chamber. The precision filtration container according to claim 9.

13. The base has a peripheral channel, which fluidly connects the third valve half chamber and the first valve half chamber. The precision filtration container according to claim 7.

14. Each valve half chamber is sealed by a valve half chamber connected by a threaded flange. A precision filtration container according to claim 1.

15. When the base is in the operating position, each valve half-chamber and / or each valve counter half-chamber has a sterile shape, that is, it can discharge any minimum amount of fluid, in other words there is no fluid stagnation zone. A precision filtration container according to claim 1.

16. When the base is in the operating position, each pipe section has a sterile shape, meaning that any minimum amount of fluid can be discharged, in other words, there are no fluid stagnation zones. The precision filtration container according to claim 6.

17. The cylindrical bell body and bell cap are firmly connected to form a single piece. A precision filtration container according to claim 1.

18. The bell cap is a single body, that is, made from a single piece. The bell cap is provided with at least one fifth valve half-chamber configured to house a fifth movable valve element configured to move from a valve open position to a valve closed position. The at least one fifth valve half chamber has at least one fifth contact surface for sealing the fifth movable valve element. A precision filtration container according to claim 1.

19. The bell cap is a single body, that is, made from a single piece. The bell cap is provided with at least one sixth valve half-chamber configured to house a sixth movable valve element configured to move from a valve open position to a valve closed position. The at least one sixth valve half-chamber has at least one sixth contact surface for sealing the sixth movable valve element. A precision filtration container according to claim 1.

20. The bell cap is a single body, that is, made from a single piece. The bell cap is provided with at least one level sensor chamber configured to connect a level sensor, having a level sensor connection flange, i.e., a zero dead leg connection flange, i.e., a ZDL connection, for connection to a clamp connection adapter unit. A precision filtration container according to claim 1.

21. The bell cap is a single body, that is, made from a single piece. The bell cap is provided with at least one manometer connection pipe for connecting a manometer. A precision filtration container according to claim 1.

22. The bell cap is a single body, that is, made from a single piece. The bell cap is provided with at least one integrity test pipe section, The at least one integrity test pipe section is fluidly connected to the sixth valve half chamber. A precision filtration container according to claim 1.

23. When the base is connected to the container bell, it defines an inner microfilter chamber housing at least one microfilter that separates the fluid inlet pipe section from the fluid outlet pipe section. A precision filtration container according to claim 1.

24. The base has at least one blind sheet for connecting the container support legs. A precision filtration container according to claim 1.

25. When the base is not attached, the microfilter sheet is positioned on the base facing outward from the opposite side with respect to the way in which the first contact surface faces outward. A precision filtration container according to claim 1.

26. When the base is not attached, the microfilter sheet is positioned on the base facing outward in a direction different from the way in which the first contact surface faces outward. A precision filtration container according to claim 1.

27. The first movable valve element is housed in the first valve half chamber so as to move along the first movable valve element movement path to contact the first contact surface. A precision filtration container according to claim 1.

28. The microfilter sheet is different from the first contact surface. A precision filtration container according to claim 1.

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